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XRN1 Gene

protein-coding GIFtS: 51

GC03M143508

5'-3' exoribonuclease 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp434P0721 ^²
DKFZp686B22225 ^²
DKFZp686F19113 ^²
EC 3.1.11.- ^³
FLJ41903 ^²
SEP1 ^¹, ², ³, ⁵

Descriptions
5'-3' exoribonuclease 1 ^²
Strand-exchange protein 1 homolog ^³
strand-exchange protein 1 ^²

External Ids
HGNC: 30654¹
Entrez Gene: 54464²
UniProtKB: Q8IZH2³
Ensembl: ENSG00000114127⁷

Search outside databases for aliases for XRN1 gene

Previous GC identifer: GC03M139058

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XRN1:

SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to

mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions,

including homologous recombination, meiosis, telomere maintenance, and microtubule

assembly.[supplied by OMIM]

UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2

Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of

the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA

tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By

similarity). May act as a tumor suppressor protein in osteogenic sarcoma (OGS)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XRN1 gene

Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23

XRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M143508: (about GC identifiers)

Start:	143,508,139 bp from pter
End:	143,649,543 bp from pter
Size:	141,405 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2 (See protein sequence)

Recommended Name: 5'-3' exoribonuclease 1

Size: 1706 amino acids; 194107 Da

Subunit: Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with

RENT1, RENT2, RENT3B and XRN1

Subcellular location: Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane

Miscellaneous: Down-regulated in OGS biopsy

Secondary accessions: Q4G0S3 Q68D88 Q6AI24 Q6MZS8 Q86WS7 Q8N8U4 Q9UF39

Alternative splicing: 3 isoforms: Q8IZH2-1 Q8IZH2-2 Q8IZH2-3

REFSEQ proteins (2 alternative transcripts):

NP_001036069.1 NP_061874.3

ENSEMBL proteins:

ENSP00000376707 ENSP00000264951

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Xrn1)
	Human Recombinant Proteins from Abnova (XRN1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for XRN1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Xrn1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XRN1)
	Novus Biologicals Antibody for XRN1

Assays for XRN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IZH2

ProtoNet protein and cluster: Q8IZH2

1 Blocks protein family: IPB004859 Putative 5-3 exonuclease domain

UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2

Similarity: Belongs to the 5'-3' exonuclease family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001042604

Applied Biosystems Silencer® siRNAs for XRN1

Sigma-Aldrich siRNA for XRN1

Sigma-Aldrich shRNA for XRN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XRN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001042604
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001042604
untagged cDNA clones in CMV expression vector (see all 3): AK096177

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_019001

UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2

Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of

the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA

tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By

similarity). May act as a tumor suppressor protein in osteogenic sarcoma (OGS)

Induction: By GDNF

Enzyme Number (IUBMB): EC 3.1.11.-

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	15231747
GO:0008409	5'-3' exonuclease activity	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/42 Interacting proteins for XRN1 (ENSP00000264951³ Q8IZH2¹) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDOA	P04075¹	EBI-372406, EBI-709613
AP1G2	O75843¹	EBI-372406, EBI-373637
BAT3	P46379¹	EBI-372406, EBI-347552
CCT5	P48643¹	EBI-372406, EBI-355710
CHD4	Q14839¹	EBI-372406, EBI-372916

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	IEA	--
GO:0045786	negative regulation of cell cycle	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XRN1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001042604

Sigma-Aldrich siRNA for XRN1

Sigma-Aldrich shRNA for XRN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001042604 NM_019001

REFSEQ mRNAs for XRN1 gene (2 alternative transcripts):

NM_001042604.1 NM_019001.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001042604 NM_019001

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001042604
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001042604
                                 untagged cDNA clones in CMV expression vector (see all 3): AK096177

Additional cDNA sequence:

AK096177.1 AK123897.1 AK304312.1 AL117516.1 AL133623.1 AY137776.1 BC039314.1 BC048104.1

BC078146.1 BX640905.1 CR627160.1 CR627396.1 CR749518.1

14 DOTS entries:

DT.97837164 DT.212252 DT.409733 DT.95263243 DT.99967252 DT.97817152 DT.100022124 DT.120912012

DT.40128661 DT.99977621 DT.40236568 DT.75102786 DT.91666774 DT.91879839

24/134 AceView cDNA sequences (see all 134 ):

AI017478 BM876356 BC039314 AA486772 BQ215043 AK123897 H68938 CN481808

CK823327 BX640905 BM677611 CR627396 AI908208 AA382099 AL133623 AA504374

AK096177 BC078146 BM457935 BM802012 BX954729 BQ433900 AI004667 AA953359

highest scoring ESTs for XRN1:

AI004667 BI561044 BQ215043 N68610 W01997 AK096177 BC039314 AA410585 AA411620 AA486772

Unigene Cluster for XRN1:

5'-3' exoribonuclease 1

Hs.435103 [show with all ESTs]

Unigene Representative Sequence: BX640905

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000392981 ENST00000264951

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XRN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XRN1

¹ / ² / ³

11 probe-sets matching XRN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
86814_at²^{, 3}	U95-D	1	1.00	1.00	0.40	0.54	AI620731	0.60	1.00	0.82	1
47090_at²^{, 3}	U95-B	1	1.00	1.00	0.75	1.56	AI004667	0.80	1.00	0.91	1
46550_at²^{, 3}	U95-B	1	0.94	1.00	0.75	1.00	W01997	0.80	1.00	0.91	1
64909_at²^{, 3}	U95-C	2	0.75	0.75	0.59	1.20	AI341683	0.20	0.25	0.23	2
42920_at²^{, 3}	U95-B	1	0.62	1.00	0.63	0.72	N68610	0.80	1.00	0.91	1
225814_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BG534738	0.60	1.00	0.82	1
233632_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL117516	0.40	1.00	0.76	1
225814_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
233632_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1570394_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555785_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks XRN1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAAATGCTC

SOURCE GeneReport for Unigene cluster: Hs.435103
UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2
Tissue specificity: Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS)
biopsy and primary cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XRN1 gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XRN1¹	--	5'-3' exoribonuclease 1	93.44(n) 93.79(a)	477100 XM_534294.2 XP_534294.2
chimpanzee (Pan troglodytes)	XRN1¹	--	5'-3' exoribonuclease 1	99.65(n) 99.24(a)	460744 XM_001161640.1 XP_001161640.1
cow (Bos taurus)	XRN1¹	--	5'-3' exoribonuclease 1	92.48(n) 92.13(a)	540834 XM_613358.3 XP_613358.3
rat (Rattus norvegicus)	Xrn1¹	--	5'-3' exoribonuclease 1	88.05(n) 89.14(a)	300944 XM_217233.4 XP_217233.4
mouse (Mus musculus)	Xrn1^{1, 5}	9⁵	5'-3' exoribonuclease 1^{1, 5}	88.01(n)¹ 88.61(a)¹	24127¹ NM_011916.2¹ NP_036046.2¹ AK052194⁵ AK142311⁵ (see all 18)

About this table Species with no ortholog for XRN1

ENSEMBL Gene Tree for XRN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XRN1 gene

XRN2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/496 NCBI SNPs in XRN1 are shown (see all 496 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 99)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3924057^1,2	A,C,F,H	143649732(+)	`GGTGTG/ATTGCA`	2	--	ng3¹		7		EU EA WA NA	550
	rs3762799^1,2	C,F,H	143510501(+)	`CAGATA/GTACTC`	2	--	ut3¹ ese³		13		EA NA EU WA	2250
	rs35902661^1,2	C,F	143548867(-)	`TGCAGT/CTCTAC`	2	A/V	mis¹		5		NA EU EA WA	488
	rs16852263^1,2	F,H	143512609(+)	`TATACT/CGGAGG`	2	--	ut3¹ ese³		7		NA EU EA WA	562
	rs35214510^1,2	C,F	143605289(-)	`AGAAAA/GGTGGT`	2	S/G	mis¹		5		NA EU EA WA	490
--	rs12695757^1,2	A,C	143507926(+)	`aaATTA/Taaaaa`	2	--	ng5¹		0	--	--	--	--
	rs2306700^1,2	C,F,H	143606531(+)	`AGGCAC/TTCACT`	2	E/E	syn¹ ese³		13		EA NA EU WA	2540
	rs2862745^1,2	A,C,F,H,O	143554622(-)	`ATATGC/TATTCC`	2	--	int¹		8		EU EA WA NA	636
	rs2862743^1,2	A,C,F,H,O	143595262(-)	`ACAGTA/GAGATG`	2	--	int¹		7		EA WA NA	514
	rs7652687^1,2	A,C,F,H	143605966(+)	`GGAAGA/GTGAGA`	2	--	int¹		7		NA EU EA WA	550

About this table

HapMap Linkage Disequilibrium images for XRN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607994

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/16 PubMed articles for XRN1 gene (see all 16 ):

The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)^{2, 3, 4} Ingelfinger D....Achsel T. (2002)
Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system. (PubMed id 14580940)^{1, 3, 4} Shimoyama Y.... Takahashi M. (2003)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. (PubMed id 14527413)^{3, 4} Lejeune F.... Maquat L.E. (2003)
The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma. (PubMed id 12426100)^{3, 4} Zhang K....Sarkar G. (2002)
Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product. (PubMed id 9802570)^{3, 4} Sato Y....Furuichi Y. (1998)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
A protein interaction framework for human mRNA degradation. (PubMed id 15231747)³ Lehner B. and Sanderson C.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54464	HGNC: 30654	AceView: XRN1	Ensembl:ENSG00000114127	euGenes: HUgn54464
ECgene: XRN1	H-InvDB: XRN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for XRN1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XRN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XRN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XRN1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XRN1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for XRN1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for XRN1

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XRN1 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for XRN1

Summaries
for XRN1

Genomic Location
for XRN1

Proteins
for XRN1

Protein Domains/
Families
for XRN1

Gene Function
for XRN1

Pathways & Interactions
for XRN1

Drugs & Compounds
for XRN1

Transcripts
for XRN1

Expression
for XRN1

Orthologs
for XRN1

Paralogs
for XRN1

SNPs/Variants
for XRN1

Disorders & Mutations
for XRN1

Medical News
for XRN1

Publications
for XRN1

Search for XRN1

Genome Databases showing XRN1

Other Databases showing XRN1

Specialized Databases showing XRN1

Licensable Technologies
for XRN1

Services
for XRN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XRN1 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor XRN1

Summariesfor XRN1

Genomic Locationfor XRN1

Proteinsfor XRN1

Protein Domains/Familiesfor XRN1

Gene Functionfor XRN1

Pathways & Interactionsfor XRN1

Drugs & Compoundsfor XRN1

Transcriptsfor XRN1

Expression for XRN1

Orthologsfor XRN1

Paralogsfor XRN1

SNPs/Variantsfor XRN1

Disorders & Mutationsfor XRN1

Medical Newsfor XRN1

Publicationsfor XRN1

Search for XRN1

Genome Databases showing XRN1

Other Databases showing XRN1

Specialized Databases showing XRN1

Licensable Technologiesfor XRN1

Servicesfor XRN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XRN1

Summaries
for XRN1

Genomic Location
for XRN1

Proteins
for XRN1

Protein Domains/
Families
for XRN1

Gene Function
for XRN1

Pathways & Interactions
for XRN1

Drugs & Compounds
for XRN1

Transcripts
for XRN1

Expression
for XRN1

Orthologs
for XRN1

Paralogs
for XRN1

SNPs/Variants
for XRN1

Disorders & Mutations
for XRN1

Medical News
for XRN1

Publications
for XRN1

Licensable Technologies
for XRN1

Services
for XRN1