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Aliases for XRN1 Gene

Aliases for XRN1 Gene

  • 5'-3' Exoribonuclease 1 2
  • 5-3 Exoribonuclease 1 2 3 5
  • Strand-Exchange Protein 1 Homolog 3 4
  • SEP1 3 4
  • EC 3.1.13.- 4

External Ids for XRN1 Gene

Previous GeneCards Identifiers for XRN1 Gene

  • GC03M139058
  • GC03M143508
  • GC03M142025
  • GC03M139398

Summaries for XRN1 Gene

Entrez Gene Summary for XRN1 Gene

  • This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for XRN1 Gene

XRN1 (5'-3' Exoribonuclease 1) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. GO annotations related to this gene include nucleic acid binding and exonuclease activity.

UniProtKB/Swiss-Prot for XRN1 Gene

  • Major 5-3 exoribonuclease involved in mRNA decay. Required for the 5-3-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRN1 Gene

Genomics for XRN1 Gene

Regulatory Elements for XRN1 Gene

Enhancers for XRN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G142997 1.4 ENCODE dbSUPER 20.9 -552.4 -552360 6.2 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A XRN1 ST13P15 PAQR9-AS1 PAQR9 PBX2P1 LOC100507389 PLS1 RNA5SP143 U2SURP LOC100289361
GH03G141481 1.4 Ensembl ENCODE dbSUPER 16.4 +964.9 964933 2.5 SIN3A BRCA1 RARA RFX5 GTF3C2 ZNF121 ZNF366 GATA2 RCOR1 FOS XRN1 YWHAQP6 RASA2 KRT18P35
GH03G142576 1.2 ENCODE 17 -130.4 -130370 3.4 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SSRP1 PBX2P1 XRN1 ATR SUCLG2P1
GH03G142849 1.5 Ensembl ENCODE dbSUPER 12.7 -402.6 -402563 2.0 PKNOX1 FOXA2 ATF1 ARNT AGO1 ARID4B TCF12 SP5 KAT8 MEF2D PBX2P1 XRN1 PCOLCE2 LOC100507389 RPL8P3
GH03G142444 1.5 FANTOM5 ENCODE 11.6 +1.0 1046 4.2 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 XRN1 RNU1-100P GC03M142421
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XRN1 on UCSC Golden Path with GeneCards custom track

Promoters for XRN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159435 562 2601 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207

Genomic Location for XRN1 Gene

Chromosome:
3
Start:
142,306,607 bp from pter
End:
142,448,062 bp from pter
Size:
141,456 bases
Orientation:
Minus strand

Genomic View for XRN1 Gene

Genes around XRN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XRN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRN1 Gene

Proteins for XRN1 Gene

  • Protein details for XRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZH2-XRN1_HUMAN
    Recommended name:
    5-3 exoribonuclease 1
    Protein Accession:
    Q8IZH2
    Secondary Accessions:
    • Q4G0S3
    • Q68D88
    • Q6AI24
    • Q6MZS8
    • Q86WS7
    • Q8N8U4
    • Q9UF39

    Protein attributes for XRN1 Gene

    Size:
    1706 amino acids
    Molecular mass:
    194107 Da
    Quaternary structure:
    • Found in a mRNP complex with UPF1, UPF2, UPF3B and XRN1 (PubMed:14527413). Associates with alpha and beta tubulins (By similarity). Interacts with DIS3L2 (PubMed:23756462). Interacts with ZC3HAV1 in an RNA-dependent manner (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258).
    Miscellaneous:
    • Down-regulated in OGS biopsy.

    Alternative splice isoforms for XRN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XRN1 Gene

Post-translational modifications for XRN1 Gene

  • Ubiquitination at posLast=7979 and Lys847
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for XRN1

No data available for DME Specific Peptides for XRN1 Gene

Domains & Families for XRN1 Gene

Protein Domains for XRN1 Gene

Suggested Antigen Peptide Sequences for XRN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZH2

UniProtKB/Swiss-Prot:

XRN1_HUMAN :
  • Belongs to the 5-3 exonuclease family.
Family:
  • Belongs to the 5-3 exonuclease family.
genes like me logo Genes that share domains with XRN1: view

No data available for Gene Families for XRN1 Gene

Function for XRN1 Gene

Molecular function for XRN1 Gene

UniProtKB/Swiss-Prot Function:
Major 5-3 exoribonuclease involved in mRNA decay. Required for the 5-3-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
UniProtKB/Swiss-Prot Induction:
By GDNF/glial cell line-derived neurotrophic factor.

Enzyme Numbers (IUBMB) for XRN1 Gene

Gene Ontology (GO) - Molecular Function for XRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002151 G-quadruplex RNA binding ISS --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0004518 nuclease activity IEA --
genes like me logo Genes that share ontologies with XRN1: view
genes like me logo Genes that share phenotypes with XRN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for XRN1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XRN1 Gene

Localization for XRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRN1 Gene

Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XRN1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
cytoskeleton 2
golgi apparatus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for XRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with XRN1: view

Pathways & Interactions for XRN1 Gene

genes like me logo Genes that share pathways with XRN1: view

Gene Ontology (GO) - Biological Process for XRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000956 nuclear-transcribed mRNA catabolic process IMP 17545563
GO:0016075 rRNA catabolic process IMP 20368444
GO:0017148 negative regulation of translation IEA --
GO:0032211 negative regulation of telomere maintenance via telomerase IC 26950371
GO:0033574 response to testosterone IEA --
genes like me logo Genes that share ontologies with XRN1: view

No data available for SIGNOR curated interactions for XRN1 Gene

Transcripts for XRN1 Gene

Unigene Clusters for XRN1 Gene

5-3 exoribonuclease 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for XRN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XRN1 Gene

No ASD Table

Relevant External Links for XRN1 Gene

GeneLoc Exon Structure for
XRN1
ECgene alternative splicing isoforms for
XRN1

Expression for XRN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XRN1 Gene

Protein differential expression in normal tissues from HIPED for XRN1 Gene

This gene is overexpressed in Amniocyte (21.8) and Heart (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XRN1 Gene



Protein tissue co-expression partners for XRN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XRN1 Gene:

XRN1

SOURCE GeneReport for Unigene cluster for XRN1 Gene:

Hs.435103

mRNA Expression by UniProt/SwissProt for XRN1 Gene:

Q8IZH2-XRN1_HUMAN
Tissue specificity: Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.

Evidence on tissue expression from TISSUES for XRN1 Gene

  • Liver(4.4)
  • Intestine(4.2)
  • Kidney(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with XRN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XRN1 Gene

Orthologs for XRN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for XRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XRN1 35 34
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia XRN1 35 34
  • 93.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia XRN1 34 35
  • 92.48 (n)
rat
(Rattus norvegicus)
Mammalia Xrn1 34
  • 88.05 (n)
mouse
(Mus musculus)
Mammalia Xrn1 16 35 34
  • 88.03 (n)
oppossum
(Monodelphis domestica)
Mammalia XRN1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XRN1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves XRN1 34 35
  • 77.5 (n)
lizard
(Anolis carolinensis)
Reptilia XRN1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xrn1 34
  • 70.49 (n)
Str.17672 34
zebrafish
(Danio rerio)
Actinopterygii xrn1 34 35
  • 64.09 (n)
zgc63635 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004430 34
  • 51.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta pcm 34 35
  • 47.3 (n)
worm
(Caenorhabditis elegans)
Secernentea xrn-1 34 35
  • 49.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes XRN1 35 37 34
  • 48.77 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL046C 34
  • 48.23 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22385g 34
  • 48.04 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes exo2 34
  • 51.13 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06678 34
  • 48.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7993 34
Species where no ortholog for XRN1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XRN1 Gene

ENSEMBL:
Gene Tree for XRN1 (if available)
TreeFam:
Gene Tree for XRN1 (if available)

Paralogs for XRN1 Gene

(1) SIMAP similar genes for XRN1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with XRN1: view

No data available for Paralogs for XRN1 Gene

Variants for XRN1 Gene

Sequence variations from dbSNP and Humsavar for XRN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs552872123 Likely benign 142,449,810(+) CATCA(A/G)CTGCT intron-variant, upstream-variant-2KB
rs577916091 Likely benign 142,449,811(+) ATCAA(A/C)TGCTT intron-variant, upstream-variant-2KB
rs869312484 Likely benign 142,450,041(-) TTGCA(C/T)TCAGA intron-variant, upstream-variant-2KB
rs750327573 Uncertain significance 142,449,357(+) TGAAC(A/C)GATAC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1802904 other 142,449,489(-) ATACA(A/G)GAAGC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for XRN1 Gene

Variant ID Type Subtype PubMed ID
dgv1412e212 CNV gain 25503493
dgv299n21 CNV gain 19592680
dgv4912n100 CNV gain 25217958
dgv619n27 CNV gain 19166990
dgv8626n54 CNV gain 21841781
esv2759182 CNV gain 17122850
esv2763767 CNV gain 21179565
esv3310022 CNV mobile element insertion 20981092
esv3443267 CNV insertion 20981092
esv34483 CNV gain 17911159
esv3562643 CNV deletion 23714750
esv3597996 CNV gain 21293372
esv3598001 CNV gain 21293372
esv7548 CNV gain 19470904
nsv1011175 CNV gain 25217958
nsv1072719 CNV deletion 25765185
nsv237317 CNV insertion 16902084
nsv523596 CNV loss 19592680
nsv523945 CNV gain 19592680
nsv528954 CNV loss 19592680

Variation tolerance for XRN1 Gene

Residual Variation Intolerance Score: 9.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XRN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XRN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRN1 Gene

Disorders for XRN1 Gene

Relevant External Links for XRN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XRN1

No disorders were found for XRN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XRN1 Gene

Publications for XRN1 Gene

  1. Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system. (PMID: 14580940) Shimoyama Y. … Takahashi M. (Neuroscience 2003) 3 4 22 64
  2. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PMID: 12515382) Ingelfinger D. … Achsel T. (RNA 2002) 2 3 4 64
  3. Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA. (PMID: 23756462) Lubas M. … Dziembowski A. (EMBO J. 2013) 3 4 64
  4. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. (PMID: 21876179) Zhu Y. … Gao G. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  5. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PMID: 18172165) Mullen T.E. … Marzluff W.F. (Genes Dev. 2008) 3 4 64

Products for XRN1 Gene

Sources for XRN1 Gene

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