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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XRN1 Gene

protein-coding   GIFtS: 53
GCID: GC03M142025

5'-3' Exoribonuclease 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
5'-3' Exoribonuclease 11 2
SEP12 3 5
Strand-Exchange Protein 1 Homolog2 3
EC 3.1.13.-3

External Ids:    HGNC: 306541   Entrez Gene: 544642   Ensembl: ENSG000001141277   OMIM: 6079945   UniProtKB: Q8IZH23   

Export aliases for XRN1 gene to outside databases

Previous GC identifers: GC03M139058 GC03M143508 GC03M139398


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XRN1 Gene:
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in
replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping
protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear
and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule
assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also
play a role in bone formation. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Sep 2013)

GeneCards Summary for XRN1 Gene: 
XRN1 (5'-3' exoribonuclease 1) is a protein-coding gene. Diseases associated with XRN1 include astrocytoma, and sarcoma, and among its related super-pathways are Deadenylation-dependent mRNA decay and Metabolism of RNA. GO annotations related to this gene include RNA binding and 5'-3' exonuclease activity.

UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2
Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4
tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4
DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in
replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XRN1 gene promoter:
         c-Fos   C/EBPbeta   AP-1   JunB   FosB   Fra-1   MyoD   LCR-F1   Nkx6-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXRN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for XRN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

XRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XRN1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M142025:  view genomic region     (about GC identifiers)

Start:
142,025,449 bp from pter      End:
142,166,904 bp from pter
Size:
141,456 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2 (See protein sequence)
Recommended Name: 5'-3' exoribonuclease 1  
Size: 1706 amino acids; 194107 Da
Subunit: Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with UPF1, UPF2, UPF3B
and XRN1. Interacts with ZC3HAV1 in an RNA-dependent manner. Interacts with DIS3L2
Subcellular location: Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane
Miscellaneous: Down-regulated in OGS biopsy
Secondary accessions: Q4G0S3 Q68D88 Q6AI24 Q6MZS8 Q86WS7 Q8N8U4 Q9UF39
Alternative splicing: 3 isoforms:  Q8IZH2-1   Q8IZH2-2   Q8IZH2-3   

Explore the universe of human proteins at neXtProt for XRN1: NX_Q8IZH2

Explore proteomics data for XRN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZH2

  • XRN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    XRN1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269786.1  NP_001269788.1  NP_061874.3  NP_001036069.1  

    ENSEMBL proteins: 
     ENSP00000264951   ENSP00000419683   ENSP00000376707   ENSP00000419219   ENSP00000418404  
     ENSP00000420786   ENSP00000420634   ENSP00000444310  
    Reactome Protein details: Q8IZH2
    Human Recombinant Protein Products for XRN1: 
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    Novus Biologicals XRN1 Protein
    Novus Biologicals XRN1 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XRN1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--

    XRN1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR004859 Put_53exo
     IPR016494 5_3_exoribonuclease_1
     IPR027073 5_3_exoribonuclease

    Graphical View of Domain Structure for InterPro Entry Q8IZH2

    ProtoNet protein and cluster: Q8IZH2

    1 Blocks protein domain: IPB004859 Putative 5-3 exonuclease domain

    UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2
    Similarity: Belongs to the 5'-3' exonuclease family


    XRN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XRN1_HUMAN, Q8IZH2
    Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4
    tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4
    DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in
    replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)
    Induction: By GDNF/glial cell line-derived neurotrophic factor

         Enzyme Number (IUBMB): EC 3.1.13.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0004527exonuclease activity ----
    GO:0005515protein binding IPI--
         
    XRN1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for XRN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XRN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XRN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XRN1 

    miRNA
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    hsa-miR-3146 hsa-miR-106a hsa-miR-218-1* hsa-miR-4325 hsa-miR-93 hsa-miR-92b hsa-miR-20a hsa-miR-519e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for XRN1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    mRNA Decay by 5' to 3' Exoribonuclease0.31
    RNA degradation0.49
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Destabilization of mRNA by Tristetraprolin (TTP)
    Destabilization of mRNA by Tristetraprolin (TTP)0.79
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.79
    4CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for XRN1 (see all 8)
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Deadenylation-dependent mRNA decay
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
    Destabilization of mRNA by Tristetraprolin (TTP)
    Metabolism of RNA


    2         Kegg Pathways  (Kegg details for XRN1):
        Ribosome biogenesis in eukaryotes
    RNA degradation


    XRN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XRN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/138 Interacting proteins for XRN1 (Q8IZH23 ENSP000002649514) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463793, ENSP000003651314I2D: score=4 STRING: ENSP00000365131
    ENSG00000096155P463793I2D: score=4 
    ENSG00000227761P463793I2D: score=4 
    ENSG00000228760P463793I2D: score=4 
    ENSG00000229524P463793I2D: score=4 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000956nuclear-transcribed mRNA catabolic process IMP17545563
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    XRN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XRN1

    Search CenterWatch for drugs/clinical trials and news about XRN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for XRN1 gene (4 alternative transcripts): 
    NM_001282857.1  NM_001282859.1  NM_019001.4  NM_001042604.1  

    Unigene Cluster for XRN1:

    5'-3' exoribonuclease 1
    Hs.435103  [show with all ESTs]
    Unigene Representative Sequence: BX640905
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264951(uc010huu.3 uc003eus.3 uc003eut.3 uc003euu.3)
    ENST00000498077 ENST00000392981 ENST00000489241 ENST00000468894 ENST00000467077
    ENST00000472625 ENST00000472697(uc003euv.1) ENST00000465507 ENST00000463916(uc003euw.3 uc011bnh.2)
    ENST00000486211 ENST00000477237 ENST00000470537 ENST00000465074 ENST00000544157

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate XRN1 (see all 104):
    hsa-miR-3146 hsa-miR-106a hsa-miR-218-1* hsa-miR-4325 hsa-miR-93 hsa-miR-92b hsa-miR-20a hsa-miR-519e
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    Additional mRNA sequence: 

    AK096177.1 AK123897.1 AK304312.1 AL117516.1 AL133623.1 AY137776.1 BC039314.1 BC048104.1 
    BC078146.1 BX640905.1 CR627160.1 CR627396.1 CR749518.1 

    14 DOTS entries:

    DT.97837164  DT.212252  DT.95263243  DT.99967252  DT.97817152  DT.100022124  DT.120912012  DT.40128661 
    DT.99977621  DT.40236568  DT.409733  DT.75102786  DT.91666774  DT.91879839 

    24/134 AceView cDNA sequences (see all 134):

    CR627396 BM677611 AA504116 BQ433900 BX640905 BX954729 BE044550 AA486772 
    AK096177 CK823327 AA382099 AK123897 AA651951 BC078146 AL133623 AA814033 
    H68938 BM802012 AI017478 BC039314 BM457935 AA953359 AI004667 CN481808 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XRN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAATGCTC
    XRN1 Expression
    About this image


    See XRN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XRN1

    SOURCE GeneReport for Unigene cluster: Hs.435103

    UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2
    Tissue specificity: Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and
    primary cell lines

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for XRN1 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xrn11 , 5 5'-3' exoribonuclease 11, 5 88.01(n)1
    88.61(a)1
      9 (50.31 cM)5
    241271  NM_011916.21  NP_036046.21 
     959547605 
    chicken
    (Gallus gallus)
    Aves XRN11 5'-3' exoribonuclease 1 77.44(n)
    78.88(a)
      424778  XM_422596.3  XP_422596.3 
    lizard
    (Anolis carolinensis)
    Reptilia XRN16
    5'-3' exoribonuclease 1
    72(a)
    1 ↔ 1
    3(21894620-21943293)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA790960.12   -- 74.3(n)    CA790960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636352 similar to 5'-3' exoribonuclease 1 78.12(n)   394008  BC055175.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pcm1 pacman 46.84(n)
    42.61(a)
      32935  NM_078684.3  NP_523408.2 
    worm
    (Caenorhabditis elegans)
    Secernentea xrn-11 Protein XRN-1 48.78(n)
    42.99(a)
      175059  NM_064544.4  NP_496945.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes XRN1(YGL173C)4
    XRN11
    Evolutionarily-conserved 5'-3' exonuclease component more4
    Xrn1p1
    48.92(n)1
    38.49(a)1
      7(180113-175527)4
    8527021, 4  NP_011342.11, 4 


    ENSEMBL Gene Tree for XRN1 (if available)
    TreeFam Gene Tree for XRN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for XRN1 gene
    1 SIMAP similar gene for XRN1 using alignment to 6 protein entries:     XRN1_HUMAN (see all proteins):
    XRN2

    XRN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2806 SNPs in XRN1 are shown (see all 2806)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130604371,2
    C,F--142025043(+) ataagA/Tatgac 2 -- ds500110Minor allele frequency- T:0.40NA WA EA 372
    rs1838426281,2
    --142025112(+) ACAAAC/TTGTGT 2 -- ds50010--------
    rs1421974291,2
    C--142025212(+) CCCAAA/TAACCT 2 -- ds50010--------
    rs126957571,2
    C,F,A--142025236(+) AAATTA/TAAAAA 2 -- ds50017Minor allele frequency- T:0.39NA WA EA 366
    rs1877505271,2
    --142025327(+) TGAAGA/GCTGCA 2 -- ds50010--------
    rs130614091,2
    C,F--142025340(+) GAGCCG/AAGATC 2 -- ds500110Minor allele frequency- A:0.40NA WA EA 372
    rs1998689301,2
    --142025381(+) CTCAA-/AAAC  
            
    AAACA
    2 -- ds50010--------
    rs1463807931,2
    C--142025433(+) AGTAAC/TAAAAG 2 -- ds50010--------
    rs1485891931,2
    C--142025515(+) TTAAAC/GTCTTT 2 -- ut310--------
    rs31914631,2
    C,F,H--142025524(-) GAGTCA/CCTGAA 2 -- ut31 ese33Minor allele frequency- C:0.22NS NA 286

    HapMap Linkage Disequilibrium report for XRN1 (142025449 - 142166904 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for XRN1 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv274294CNV Insertion20981092
    nsv237317CNV Insertion16902084
    nsv528954CNV Loss19592680
    nsv877557CNV Loss21882294
    nsv523596CNV Loss19592680
    nsv877556CNV Loss21882294
    dgv5266n71CNV Loss21882294
    dgv299n21CNV Gain19592680
    esv34483CNV Gain17911159
    esv7548CNV Gain19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607994    OMIM disorders: --

    2 diseases for XRN1:    About MalaCards
    astrocytoma    sarcoma


    XRN1 for disorders           About GeneDecksing


    Export disorders for XRN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XRN1 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with XRN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)1, 2, 3 Ingelfinger D....Achsel T. (2002)
    2. Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system. (PubMed id 14580940)1, 2, 9 Shimoyama Y.... Takahashi M. (2003)
    3. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. (PubMed id 14527413)1, 2 Lejeune F.... Maquat L.E. (2003)
    7. The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma. (PubMed id 12426100)1, 2 Zhang K....Sarkar G. (2002)
    8. Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product. (PubMed id 9802570)1, 2 Sato Y....Furuichi Y. (1998)
    9. Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA. (PubMed id 23756462)2 Lubas M....Dziembowski A. (2013)
    10. Degradation of initiator tRNAMet by Xrn1/2 via its acc umulation in the nucleus of heat-treated HeLa cells. (PubMed id 23471000)1 Watanabe K....Ijiri K. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54464 HGNC: 30654 AceView: XRN1 Ensembl:ENSG00000114127 euGenes: HUgn54464
    ECgene: XRN1 Kegg: 54464 H-InvDB: XRN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XRN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for XRN1 gene:
    Search GeneIP for patents involving XRN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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