XRN1 Gene
protein-coding GIFtS: 51
GCID: GC03M142025
|
|
5'-3' exoribonuclease 1
| |
Aliases
for XRN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5'-3' Exoribonuclease 11 2 | | SEP11 2 3 5 | | Strand-Exchange Protein 1 Homolog2 3 | | EC 3.1.11.-3 |
Export aliases for XRN1 gene to outside databasesPrevious GC identifers: GC03M139058 GC03M143508 GC03M139398 |
Summaries
for XRN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XRN1:
SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism,yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination,meiosis, telomere maintenance, and microtubule assembly.(supplied by OMIM, Apr 2004)
UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNAtetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependenthistone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)
|
Genomic Views
for XRN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XRN1 gene promoter:
c-Fos C/EBPbeta AP-1 JunB FosB Fra-1 MyoD LCR-F1 Nkx6-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for XRN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23XRN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M142025: view genomic region
(about GC identifiers)
Start:
|
142,025,449 bp from pter |
End:
|
142,166,904 bp from pter |
Size:
|
141,456 bases |
Orientation:
|
minus strand |
|
Proteins
for XRN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2 (See
protein sequence)Recommended Name: 5'-3' exoribonuclease 1 Size: 1706 amino acids; 194107 Da
Subunit: Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with UPF1, UPF2, UPF3B andXRN1. Interacts with ZC3HAV1 in an RNA-dependent manner
Subcellular location: Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane
Miscellaneous: Down-regulated in OGS biopsy
Secondary accessions: Q4G0S3 Q68D88 Q6AI24 Q6MZS8 Q86WS7 Q8N8U4 Q9UF39Alternative splicing: 3 isoforms: Q8IZH2-1 Q8IZH2-2 Q8IZH2-3 Explore the universe of human proteins at neXtProt for XRN1: NX_Q8IZH2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZH2
XRN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001036069.1 NP_061874.3
ENSEMBL proteins: ENSP00000264951 ENSP00000419683 ENSP00000376707 ENSP00000419219 ENSP00000418404 ENSP00000420786 ENSP00000420634 ENSP00000444310 Reactome Protein details: Q8IZH2
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
XRN1 for ontologies About GeneDecksing
XRN1 Antibody Products:
Assay Products for XRN1: |
Protein
Domains /
Families
for XRN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XRN1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZH2ProtoNet protein and cluster: Q8IZH2 1 Blocks protein family: IPB004859 Putative 5-3 exonuclease domain
UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2Similarity: Belongs to the 5'-3' exonuclease family |
Function
for XRN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNAtetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependenthistone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)Induction: By GDNF/glial cell line-derived neurotrophic factorEnzyme Number (IUBMB): EC 3.1.11.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRN1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): XRN1 (NM_019001) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
XRN1 for ontologies About GeneDecksing
|
Pathways & Interactions
for XRN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | Metabolism of mRNA | | | 3 | Destabilization of mRNA by Tristetraprolin (TTP) | | | 4 | Ribosome biogenesis in eukaryotes | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for XRN1 (see all 8)
2 
Kegg Pathways (Kegg details for XRN1):
XRN1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XRN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/122 Interacting proteins for XRN1 (Q8IZH23 ENSP000002649514) via UniProtKB, MINT, STRING, and/or I2D (see all 122)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0000956 | nuclear-transcribed mRNA catabolic process |
IMP | 17545563 | | GO:0010467 | gene expression |
TAS | -- | | GO:0016070 | RNA metabolic process |
TAS | -- | | GO:0016071 | mRNA metabolic process |
TAS | -- |
XRN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for XRN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XRN1
Search CenterWatch for drugs/clinical trials and news about XRN1
|
Transcripts
for XRN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XRN1 gene (2 alternative transcripts): NM_001042604.1 NM_019001.3 Unigene Cluster for XRN1: 5'-3' exoribonuclease 1 Hs.435103 [show with all ESTs]Unigene Representative Sequence: BX64090515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264951(uc010huu.3 uc003eus.3 uc003eut.3 uc003euu.3)
ENST00000498077 ENST00000392981 ENST00000489241 ENST00000468894 ENST00000467077
ENST00000472625 ENST00000472697(uc003euv.1) ENST00000465507 ENST00000463916(uc003euw.3 uc011bnh.2)
ENST00000486211 ENST00000477237 ENST00000470537 ENST00000465074 ENST00000544157
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRN1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): XRN1 (NM_019001) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRN1 |
Additional cDNA sequence: AK096177.1 AK123897.1 AK304312.1 AL117516.1 AL133623.1 AY137776.1 BC039314.1 BC048104.1 BC078146.1 BX640905.1 CR627160.1 CR627396.1 CR749518.1 14 DOTS entries: DT.97837164 DT.212252 DT.95263243 DT.99967252 DT.97817152 DT.100022124 DT.120912012 DT.40128661 DT.99977621 DT.40236568 DT.409733 DT.75102786 DT.91666774 DT.91879839 24/134 AceView cDNA sequences (see all 134): AK123897 AA814033 H68938 BM802012 AI017478 AL133623 BC078146 BM876356 BQ433900 BM457935 AA953359 CN481808 AK096177 AY137776 BC048104 AA486772 AI004667 NM_019001 AA504374 AA651951 BE044550 CR627396 BQ215043 CK823327
GeneLoc Exon Structure
|
Expression
for XRN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XRN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAATGCTC
About this image
See XRN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XRN1
SOURCE GeneReport for Unigene cluster: Hs.435103
UniProtKB/Swiss-Prot: XRN1_HUMAN, Q8IZH2Tissue specificity: Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primarycell lines
SABiosciences Custom PCR Arrays for XRN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XRN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN1 |
Orthologs
for XRN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for XRN1 gene from 7/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
XRN11 |
5'-3' exoribonuclease 1 |
77.44(n)
78.88(a) |
|
424778 XM_422596.3 XP_422596.3 |
lizard
(Anolis carolinensis) |
Reptilia |
XRN16 |
-- |
74(a) |
1 ↔ 1 |
3(21894851-21942663) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CA790960.12 |
-- |
74.3(n) |
|
CA790960.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636352 |
similar to 5'-3' exoribonuclease 1 |
78.12(n) |
|
394008 BC055175.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
pcm1 |
pacman |
46.84(n)
42.61(a) |
|
32935 NM_078684.3 NP_523408.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
xrn-11 |
Protein XRN-1 |
48.78(n)
42.99(a) |
|
175059 NM_064544.4 NP_496945.3 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
XRN1(YGL173C)4
XRN11 |
Evolutionarily-conserved 5'-3' exonuclease component more4
Xrn1p1 |
48.92(n)1
38.49(a)1 |
|
7(180113-175527)4
8527021, 4 NP_011342.11, 4 |
ENSEMBL Gene Tree for XRN1 (if available)
TreeFam Gene Tree for XRN1 (if available) |
Paralogs
for XRN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for XRN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XRN1 (142025449 - 142166904 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for XRN1
5 CNVs: 8431 50949 53086 2476 3451
1 Indel: 60437 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRN1 |
|
Disorders
/ Diseases
for XRN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XRN1 for disorders About GeneDecksing
OMIM gene information: 607994
OMIM disorders: --
3  diseases for XRN1: About MalaCardsastrocytoma sarcoma malaria
Export disorders for XRN1 gene to outside databases
|
Publications
for XRN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XRN1 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with XRN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)1, 2, 3 Ingelfinger D....Achsel T. (2002)
- Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system. (PubMed id 14580940)1, 2, 9 Shimoyama Y.... Takahashi M. (2003)
- Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. (PubMed id 14527413)1, 2 Lejeune F.... Maquat L.E. (2003)
- The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma. (PubMed id 12426100)1, 2 Zhang K....Sarkar G. (2002)
- Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product. (PubMed id 9802570)1, 2 Sato Y....Furuichi Y. (1998)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
|
External Searches for XRN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing XRN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XRN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XRN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for XRN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for XRN1 gene:
Search GeneIP for patents involving XRN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XRN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XRN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRN1 | | | OriGene Protein Over-expression Lysate for XRN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XRN1 | | OriGene 3'-UTR Clone for XRN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XRN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRN1 |
| |
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| | | | Search Tocris compounds for XRN1 |
| |  |  |  |  | | | | |
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 |
 |
 | | | XRN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRN1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRN1 |
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