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Aliases for XRCC6BP1 Gene

Aliases for XRCC6BP1 Gene

  • XRCC6 Binding Protein 1 2 3
  • XRCC6-Binding Protein 1 3 4
  • Ku70 Binding Protein 3 2 3
  • Ku70-Binding Protein 3 3 4
  • KUB3 3 4
  • Mitochondrial Inner Membrane Protease ATP23 Homolog 3
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for XRCC6BP1 Gene

Summaries for XRCC6BP1 Gene

GeneCards Summary for XRCC6BP1 Gene

XRCC6BP1 (XRCC6 Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and DNA-dependent protein kinase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC6BP1 Gene

Genomics for XRCC6BP1 Gene

Genomic Location for XRCC6BP1 Gene

Start:
57,941,541 bp from pter
End:
57,957,269 bp from pter
Size:
15,729 bases
Orientation:
Plus strand

Genomic View for XRCC6BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XRCC6BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRCC6BP1 Gene

Regulatory Elements for XRCC6BP1 Gene

Proteins for XRCC6BP1 Gene

  • Protein details for XRCC6BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6H3-ATP23_HUMAN
    Recommended name:
    Mitochondrial inner membrane protease ATP23 homolog
    Protein Accession:
    Q9Y6H3
    Secondary Accessions:
    • Q1RLM4
    • Q96E81

    Protein attributes for XRCC6BP1 Gene

    Size:
    246 amino acids
    Molecular mass:
    28081 Da
    Quaternary structure:
    • Interacts with XRCC6.
    SequenceCaution:
    • Sequence=AAD31085.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for XRCC6BP1 Gene

Proteomics data for XRCC6BP1 Gene at MOPED

Selected DME Specific Peptides for XRCC6BP1 Gene

Post-translational modifications for XRCC6BP1 Gene

No Post-translational modifications

Other Protein References for XRCC6BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for XRCC6BP1 Gene

Protein Domains for XRCC6BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XRCC6BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6H3

UniProtKB/Swiss-Prot:

ATP23_HUMAN
Family:
  • Belongs to the peptidase M76 family.:
    • Q9Y6H3
genes like me logo Genes that share domains with XRCC6BP1: view

No data available for Gene Families for XRCC6BP1 Gene

Function for XRCC6BP1 Gene

Enzyme Numbers (IUBMB) for XRCC6BP1 Gene

Gene Ontology (GO) - Molecular Function for XRCC6BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0004677 DNA-dependent protein kinase activity TAS 10219089
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with XRCC6BP1: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XRCC6BP1 Gene

Localization for XRCC6BP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XRCC6BP1 Gene COMPARTMENTS Subcellular localization image for XRCC6BP1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for XRCC6BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex NAS 10219089
genes like me logo Genes that share ontologies with XRCC6BP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for XRCC6BP1 Gene

Pathways for XRCC6BP1 Gene

SuperPathways for XRCC6BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for XRCC6BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006303 double-strand break repair via nonhomologous end joining TAS 10219089
GO:0006468 protein phosphorylation TAS 10219089
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with XRCC6BP1: view

No data available for Pathways by source for XRCC6BP1 Gene

Transcripts for XRCC6BP1 Gene

Unigene Clusters for XRCC6BP1 Gene

XRCC6 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XRCC6BP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - - -

Relevant External Links for XRCC6BP1 Gene

GeneLoc Exon Structure for
XRCC6BP1
ECgene alternative splicing isoforms for
XRCC6BP1

Expression for XRCC6BP1 Gene

mRNA expression in normal human tissues for XRCC6BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XRCC6BP1 Gene

This gene is overexpressed in Testis (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XRCC6BP1 Gene

SOURCE GeneReport for Unigene cluster for XRCC6BP1 Gene Hs.61188

genes like me logo Genes that share expressions with XRCC6BP1: view

No data available for mRNA Expression by UniProt/SwissProt for XRCC6BP1 Gene

Orthologs for XRCC6BP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XRCC6BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XRCC6BP1 35
  • 99.19 (n)
  • 98.78 (a)
XRCC6BP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XRCC6BP1 35
  • 89.16 (n)
  • 90.24 (a)
XRCC6BP1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XRCC6BP1 35
  • 90.62 (n)
  • 88.84 (a)
XRCC6BP1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xrcc6bp1 35
  • 79.95 (n)
  • 80.49 (a)
Xrcc6bp1 16
Xrcc6bp1 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XRCC6BP1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XRCC6BP1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xrcc6bp1 35
  • 79.27 (n)
  • 79.67 (a)
chicken
(Gallus gallus)
Aves XRCC6BP1 35
  • 70.96 (n)
  • 66.09 (a)
XRCC6BP1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XRCC6BP1 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia kub3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16237 35
xrcc6bp1 35
  • 72.15 (n)
  • 71 (a)
zebrafish
(Danio rerio)
Actinopterygii xrcc6bp1 35
  • 64.57 (n)
  • 65.69 (a)
xrcc6bp1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009567 35
  • 51.3 (n)
  • 43.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5131 35
  • 52.64 (n)
  • 45.9 (a)
CG5131 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP23 36
  • 26 (a)
OneToOne
ATP23 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03420 35
  • 52.52 (n)
  • 41.86 (a)
rice
(Oryza sativa)
Liliopsida Os12g0288900 35
  • 47.22 (n)
  • 40.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp23 35
  • 50.67 (n)
  • 39.31 (a)
Species with no ortholog for XRCC6BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRCC6BP1 Gene

ENSEMBL:
Gene Tree for XRCC6BP1 (if available)
TreeFam:
Gene Tree for XRCC6BP1 (if available)

Paralogs for XRCC6BP1 Gene

No data available for Paralogs for XRCC6BP1 Gene

Variants for XRCC6BP1 Gene

Sequence variations from dbSNP and Humsavar for XRCC6BP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10122 -- 57,956,848(+) GCTCA(C/T)AGAGA reference, synonymous-codon
rs2888286 -- 57,940,086(-) ATATA(C/T)ATTTG upstream-variant-2KB
rs2888287 -- 57,939,942(-) tgaac(A/G)ttgta upstream-variant-2KB
rs3751325 - 57,941,843(-) GTTGC(A/T)GGTGA reference, missense, utr-variant-5-prime, upstream-variant-2KB
rs3751326 -- 57,941,547(-) GGAGG(C/G)GGCTT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for XRCC6BP1 Gene

Variant ID Type Subtype PubMed ID
nsv523853 CNV Gain 19592680

Relevant External Links for XRCC6BP1 Gene

HapMap Linkage Disequilibrium report
XRCC6BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC6BP1 Gene

Disorders for XRCC6BP1 Gene

No disorders were found for XRCC6BP1 Gene.

No data available for UniProtKB/Swiss-Prot for XRCC6BP1 Gene

Publications for XRCC6BP1 Gene

  1. Isolation of Ku70-binding proteins (KUBs). (PMID: 10219089) Yang C.-R. … Boothman D.A. (Nucleic Acids Res. 1999) 2 3 4
  2. KUB3 amplification and overexpression in human gliomas. (PMID: 11571779) Fischer U. … Meese E. (Glia 2001) 3 23
  3. Amplicons on chromosome 12q13-21 in glioblastoma recurrences. (PMID: 19839052) Fischer U. … Meese E. (Int. J. Cancer 2010) 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Glioma-amplified sequence KUB3 influences double-strand break repair after ionizing radiation. (PMID: 23670597) Fischer U. … Meese E. (Int. J. Oncol. 2013) 3

Products for XRCC6BP1 Gene

Sources for XRCC6BP1 Gene

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