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Aliases for XRCC6 Gene

Aliases for XRCC6 Gene

  • X-Ray Repair Cross Complementing 6 2 3 5
  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6 2 3 4
  • Thyroid Autoantigen 70kDa (Ku Antigen) 2 3
  • ATP-Dependent DNA Helicase 2 Subunit 1 3 4
  • Thyroid Autoantigen 70kD (Ku Antigen) 2 3
  • 5-Deoxyribose-5-Phosphate Lyase Ku70 3 4
  • Lupus Ku Autoantigen Protein P70 3 4
  • 70 KDa Subunit Of Ku Antigen 3 4
  • DNA Repair Protein XRCC6 3 4
  • Ku Autoantigen, 70kDa 2 3
  • 5-DRP Lyase Ku70 3 4
  • CTCBF 3 4
  • G22P1 3 4
  • CTC75 3 4
  • TLAA 3 4
  • KU70 3 4
  • ATP-Dependent DNA Helicase II, 70 KDa Subunit 3
  • ATP-Dependent DNA Helicase II 70 KDa Subunit 4
  • X-Ray Repair Cross-Complementing Protein 6 3
  • CTC Box Binding Factor 75 KDa Subunit 3
  • CTC Box-Binding Factor 75 KDa Subunit 4
  • Thyroid-Lupus Autoantigen P70 3
  • Ku Autoantigen P70 Subunit 3
  • Thyroid-Lupus Autoantigen 4
  • EC 4.2.99.- 4
  • EC 3.6.4.- 4
  • ML8 3

External Ids for XRCC6 Gene

Previous HGNC Symbols for XRCC6 Gene

  • G22P1

Previous GeneCards Identifiers for XRCC6 Gene

  • GC22P040342
  • GC22P042017
  • GC22P024982

Summaries for XRCC6 Gene

Entrez Gene Summary for XRCC6 Gene

  • The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

GeneCards Summary for XRCC6 Gene

XRCC6 (X-Ray Repair Cross Complementing 6) is a Protein Coding gene. Diseases associated with XRCC6 include Immune System Disease and Lupus Erythematosus. Among its related pathways are Immune System and HIV Life Cycle. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for XRCC6 Gene

  • Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3-5 direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5-deoxyribose-5-phosphate lyase (5-dRP lyase), by catalyzing the beta-elimination of the 5 deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5-dRP lyase activity allows to clean the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

Gene Wiki entry for XRCC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC6 Gene

Genomics for XRCC6 Gene

Regulatory Elements for XRCC6 Gene

Enhancers for XRCC6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F042612 1.2 ENCODE 47.3 +993.4 993366 4.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 XRCC6 RPL5P34 FAM109B RRP7BP CYB5R3 SERHL2 ATP5L2 NAGA GC22P042614 PIR37149
GH22F042077 1.1 ENCODE 41.6 +458.1 458143 3.9 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SMDT1 EP300 PHF5A RPL5P34 CYP2D6 XRCC6 RN7SKP80 EP300-AS1 ENSG00000232754 RRP7BP
GH22F041444 1.6 FANTOM5 ENCODE 26.6 -174.4 -174404 5.9 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 EP300 PHF5A XRCC6 FAM109B ENSG00000232754 EP300-AS1 MEI1 NAGA HMGN2P10 POLR3H
GH22F041559 1.1 ENCODE 37.9 -58.0 -58037 6.9 HDGF PKNOX1 ZFP64 ARID4B ZNF302 ZNF143 FOS ZNF263 SP3 REST EP300 PHF5A XRCC6 MEI1 ENSG00000232754 EP300-AS1 POLR3H RPL4P6 CSDC2 TOB2
GH22F041831 1.2 ENCODE 32.3 +212.1 212083 4.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 EP300 XRCC6 EP300-AS1 ENSG00000232754 RPL5P34 OGFRP1 CYP2D8P MEI1 PHF5A CSDC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XRCC6 on UCSC Golden Path with GeneCards custom track

Promoters for XRCC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000618797 -119 2801 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for XRCC6 Gene

Chromosome:
22
Start:
41,621,119 bp from pter
End:
41,664,048 bp from pter
Size:
42,930 bases
Orientation:
Plus strand

Genomic View for XRCC6 Gene

Genes around XRCC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XRCC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XRCC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRCC6 Gene

Proteins for XRCC6 Gene

  • Protein details for XRCC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12956-XRCC6_HUMAN
    Recommended name:
    X-ray repair cross-complementing protein 6
    Protein Accession:
    P12956
    Secondary Accessions:
    • B1AHC8
    • Q6FG89
    • Q9UCQ2
    • Q9UCQ3

    Protein attributes for XRCC6 Gene

    Size:
    609 amino acids
    Molecular mass:
    69843 Da
    Quaternary structure:
    • Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70. The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex to form the core of the non-homologous end joining (NHEJ) complex. Additional components of the NHEJ complex include NHEJ1/XLF and C9orf142/PAXX (PubMed:25574025, PubMed:25941166, PubMed:25670504). The dimer also associates with NAA15, and this complex binds to the osteocalcin promoter and activates osteocalcin expression. In addition, XRCC6 interacts with the osteoblast-specific transcription factors MSX2, RUNX2 and DLX5. Interacts with ELF3. Interacts with ATP23. The XRCC5/6 dimer associates in a DNA-dependent manner with APEX1. Binds to CDK9 isoform 2. Identified in a complex with DEAF1 and XRCC5. Interacts with DEAF1 (via the SAND domain); the interaction is direct and may be inhibited by DNA-binding (PubMed:10219089, PubMed:11493912, PubMed:12145306, PubMed:12509254, PubMed:12547193, PubMed:15075319, PubMed:20493174, PubMed:22442688, PubMed:8621488, PubMed:9742108). Interacts with CLU (By similarity). Interacts with NR4A3; the DNA-dependent protein kinase complex DNA-PK phosphorylates and activates NR4A3 and prevents NR4A3 ubiquitinylation and degradation (PubMed:25852083). Interacts with MRI isoform 1 (MRI-1) and isoform 4 (MRI-2) (PubMed:24610814).
    Miscellaneous:
    • Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to XRCC5 and XRCC6. Existence of a major autoantigenic epitope or epitopes on the C-terminal 190 amino acids of XRCC6 containing the leucine repeat. The majority of autoantibodies to XRCC6 in most sera from patients with SLE seem to be reactive with this region.

    Three dimensional structures from OCA and Proteopedia for XRCC6 Gene

    Alternative splice isoforms for XRCC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XRCC6 Gene

Post-translational modifications for XRCC6 Gene

  • Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.
  • Ubiquitination at Lys 100, Lys 114, Lys 123, Lys 182, Lys 238, Lys 287, Lys 317, Lys 351, Lys 357, Lys 445, Lys 451, Lys 461, Lys 565, Lys 570, Lys 575, and Lys 605
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for XRCC6 Gene

Domains & Families for XRCC6 Gene

Gene Families for XRCC6 Gene

Graphical View of Domain Structure for InterPro Entry

P12956

UniProtKB/Swiss-Prot:

XRCC6_HUMAN :
  • Contains 1 Ku domain.
  • Belongs to the ku70 family.
Domain:
  • Contains 1 Ku domain.
  • Contains 1 SAP domain.
Family:
  • Belongs to the ku70 family.
genes like me logo Genes that share domains with XRCC6: view

Function for XRCC6 Gene

Molecular function for XRCC6 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3-5 direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5-deoxyribose-5-phosphate lyase (5-dRP lyase), by catalyzing the beta-elimination of the 5 deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5-dRP lyase activity allows to clean the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.
UniProtKB/Swiss-Prot Induction:
In osteoblasts, by FGF2.

Enzyme Numbers (IUBMB) for XRCC6 Gene

Gene Ontology (GO) - Molecular Function for XRCC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,NAS 1537839
GO:0003684 damaged DNA binding IEA,IBA --
GO:0003690 double-stranded DNA binding TAS 7957065
GO:0003691 contributes_to double-stranded telomeric DNA binding IDA 10409678
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with XRCC6: view
genes like me logo Genes that share phenotypes with XRCC6: view

Animal Models for XRCC6 Gene

MGI Knock Outs for XRCC6:

Animal Model Products

miRNA for XRCC6 Gene

miRTarBase miRNAs that target XRCC6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for XRCC6

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XRCC6 Gene

Localization for XRCC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRCC6 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XRCC6 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for XRCC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000783 nuclear telomere cap complex TAS 15100233
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0005634 nucleus IEA,TAS 10508516
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IDA 12145306
genes like me logo Genes that share ontologies with XRCC6: view

Pathways & Interactions for XRCC6 Gene

genes like me logo Genes that share pathways with XRCC6: view

Pathways by source for XRCC6 Gene

1 KEGG pathway for XRCC6 Gene
1 GeneGo (Thomson Reuters) pathway for XRCC6 Gene
2 Qiagen pathways for XRCC6 Gene

SIGNOR curated interactions for XRCC6 Gene

Activates:

Gene Ontology (GO) - Biological Process for XRCC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IEA,TAS 15824061
GO:0006266 DNA ligation TAS 9826654
GO:0006281 DNA repair IEA --
GO:0006303 double-strand break repair via nonhomologous end joining IEA,TAS 15824061
GO:0006310 DNA recombination IBA --
genes like me logo Genes that share ontologies with XRCC6: view

Drugs & Compounds for XRCC6 Gene

(11) Drugs for XRCC6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for XRCC6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XRCC6: view

Transcripts for XRCC6 Gene

Unigene Clusters for XRCC6 Gene

X-ray repair complementing defective repair in Chinese hamster cells 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for XRCC6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XRCC6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for XRCC6 Gene

GeneLoc Exon Structure for
XRCC6
ECgene alternative splicing isoforms for
XRCC6

Expression for XRCC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XRCC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XRCC6 Gene



Protein tissue co-expression partners for XRCC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XRCC6 Gene:

XRCC6

SOURCE GeneReport for Unigene cluster for XRCC6 Gene:

Hs.292493
genes like me logo Genes that share expression patterns with XRCC6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for XRCC6 Gene

Orthologs for XRCC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XRCC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XRCC6 34 35
  • 97.65 (n)
dog
(Canis familiaris)
Mammalia XRCC6 34 35
  • 87.13 (n)
cow
(Bos Taurus)
Mammalia XRCC6 34 35
  • 86.61 (n)
rat
(Rattus norvegicus)
Mammalia Xrcc6 34
  • 83.17 (n)
mouse
(Mus musculus)
Mammalia Xrcc6 34 16 35
  • 82.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia XRCC6 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves XRCC6 34 35
  • 71.55 (n)
lizard
(Anolis carolinensis)
Reptilia XRCC6 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xrcc6 34
  • 66.21 (n)
Str.11953 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398357 34
zebrafish
(Danio rerio)
Actinopterygii LOC100536337 34
  • 62.21 (n)
OTTDARG00000020547 35
  • 58 (a)
OneToMany
xrcc6 35
  • 58 (a)
OneToMany
wufi87b06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6264 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002690 34
  • 45.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta Irbp 34 35
  • 40.48 (n)
worm
(Caenorhabditis elegans)
Secernentea cku-70 34 35
  • 41.08 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06226g 34
  • 39.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKU70 34 35 37
  • 38.31 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons KU70 34
  • 44.17 (n)
rice
(Oryza sativa)
Liliopsida Os07g0184900 34
  • 43.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08290 34
  • 42.54 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pku70 34
  • 41.61 (n)
Species where no ortholog for XRCC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XRCC6 Gene

ENSEMBL:
Gene Tree for XRCC6 (if available)
TreeFam:
Gene Tree for XRCC6 (if available)

Paralogs for XRCC6 Gene

(1) SIMAP similar genes for XRCC6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with XRCC6: view

No data available for Paralogs for XRCC6 Gene

Variants for XRCC6 Gene

Sequence variations from dbSNP and Humsavar for XRCC6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10428064 -- 41,630,045(+) gtggc(A/G)caatc intron-variant
rs11090053 -- 41,656,013(+) CGCCT(G/T)AGCCC intron-variant
rs111485320 -- 41,658,691(+) CGGGT(A/G)GATCA intron-variant
rs111496683 -- 41,651,461(+) GTTTC(A/G)GCTCA intron-variant
rs111512580 -- 41,636,846(+) GTTCA(G/T)GAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XRCC6 Gene

Variant ID Type Subtype PubMed ID
esv3647801 CNV loss 21293372
nsv1055166 CNV gain 25217958
nsv524585 CNV loss 19592680
nsv834209 CNV loss 17160897
nsv964635 CNV duplication 23825009
nsv966111 CNV duplication 23825009

Variation tolerance for XRCC6 Gene

Residual Variation Intolerance Score: 8.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XRCC6 Gene

Human Gene Mutation Database (HGMD)
XRCC6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XRCC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC6 Gene

Disorders for XRCC6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for XRCC6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
immune system disease
  • immune system and disorders
lupus erythematosus
  • lupus
lig4 syndrome
  • dna ligase iv deficiency
postencephalitic parkinson disease
  • postencephalitic parkinsonism
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards
Search XRCC6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for XRCC6

Genetic Association Database (GAD)
XRCC6
Human Genome Epidemiology (HuGE) Navigator
XRCC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XRCC6
genes like me logo Genes that share disorders with XRCC6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XRCC6 Gene

Publications for XRCC6 Gene

  1. Pterygium and genetic polymorphism of DNA double strand break repair gene Ku70. (PMID: 17768380) Tsai Y.Y. … Tsai F.J. (Mol. Vis. 2007) 3 22 46 64
  2. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PMID: 15075319) Wang H. … Oettgen P. (J. Biol. Chem. 2004) 3 4 22 64
  3. Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility. (PMID: 12750264) Fu Y.P. … Shen C.Y. (Cancer Res. 2003) 3 22 46 64
  4. The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70. (PMID: 11457852) Zhang Z. … Chen Y. (J. Biol. Chem. 2001) 3 4 22 64
  5. DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. (PMID: 10026262) Chan D.W. … Lees-Miller S.P. (Biochemistry 1999) 3 4 22 64

Products for XRCC6 Gene

Sources for XRCC6 Gene

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