XRCC6 Gene
protein-coding GIFtS: 67
GCID: GC22P042017
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|
X-ray repair complementing defective repair in Chinese hamster...(Previous names: thyroid autoantigen 70kD (Ku antigen), thyroid autoantigen...)
(Previous symbol: G22P1)
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Aliases
for XRCC6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 61 2 3 | | CTC Box-Binding Factor 75 KDa Subunit2 3 | | G22P11 2 3 5 | | DNA Repair Protein XRCC62 3 | | TLAA2 3 5 | | Ku703 5 | | KU701 2 | | D22S6711 | | ML81 2 | | D22S7311 | | Thyroid Autoantigen 70kD (Ku Antigen)1 2 | | ATP-Dependent DNA Helicase II, 70 KDa Subunit2 | | Thyroid Autoantigen 70kDa (Ku Antigen)1 2 | | CTC Box Binding Factor 75 KDa Subunit2 | | Lupus Ku Autoantigen Protein P702 3 | | Ku Autoantigen P70 Subunit2 | | 5'-Deoxyribose-5-Phosphate Lyase Ku702 3 | | Ku Autoantigen, 70kDa2 | | 5'-DRP Lyase Ku702 3 | | Thyroid-Lupus Autoantigen P702 | | 70 KDa Subunit Of Ku Antigen2 3 | | X-Ray Repair Cross-Complementing Protein 62 | | CTC752 3 | | EC 3.6.4.-3 | | CTCBF2 3 | | EC 4.2.99.-3 | | ATP-Dependent DNA Helicase 2 Subunit 12 3 | | Thyroid-Lupus Autoantigen3 | | ATP-Dependent DNA Helicase II 70 KDa Subunit2 3 | | |
Export aliases for XRCC6 gene to outside databasesPrevious GC identifers: GC22P040342 GC22P024982 |
Summaries
for XRCC6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XRCC6:
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involvedin the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)Jrecombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupuserythematosus. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: XRCC6_HUMAN, P12956Function: Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNAhelicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. Itworks in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining(NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunitof the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. Theassembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin geneexpression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing thebeta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activityallows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks,before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator oftranscription
Gene Wiki entry for XRCC6 (Ku70)
|
Genomic Views
for XRCC6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XRCC6 gene promoter:
POU2F1 Sp1 POU2F1a p300 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for XRCC6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2XRCC6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P042017: view genomic region
(about GC identifiers)
Start:
|
42,017,123 bp from pter |
End:
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42,060,052 bp from pter |
Size:
|
42,930 bases |
Orientation:
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plus strand |
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Proteins
for XRCC6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XRCC6_HUMAN, P12956 (See
protein sequence)Recommended Name: X-ray repair cross-complementing protein 6 Size: 609 amino acids; 69843 Da
Subunit: Heterodimer of a 70 kDa (XRCC6) and a 80 kDa (XRCC5) subunit. The dimer associates in a DNA-dependent mannerwith PRKDC to form the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex. The dimer alsoassociates with NAA15, and this complex binds to the osteocalcin promoter and activates osteocalcin expression. Inaddition, XRCC6 interacts with the osteoblast-specific transcription factors MSX2, RUNX2 and DLX5. Interacts withELF3. Interacts with XRCC6BP1. The XRCC5/6 dimer associates in a DNA-dependent manner with APEX1. Interacts with CLU(By similarity). Binds to CDK9 isoform 2
Subcellular location: Nucleus. Chromosome
Developmental stage: Expression does not increase during promyelocyte differentiation
Miscellaneous: Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely largeamounts of autoantibodies to XRCC5 and XRCC6. Existence of a major autoantigenic epitope or epitopes on the C-terminal190 amino acids of XRCC6 containing the leucine repeat. The majority of autoantibodies to XRCC6 in most sera frompatients with SLE seem to be reactive with this region
4 PDB 3D structures from  and Proteopedia  for XRCC6:1JEQ (3D)
1JEY (3D)
1JJR (3D)
3RZX (3D)
Secondary accessions: Q6FG89 Q9UCQ2 Q9UCQ3Explore the universe of human proteins at neXtProt for XRCC6: NX_P12956
Post-translational modifications:
Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P12956
XRCC6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001460.1
ENSEMBL proteins: ENSP00000353192 ENSP00000384941 ENSP00000352257 ENSP00000384257 ENSP00000384104 ENSP00000384082 ENSP00000403679 Reactome Protein details: P12956
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
XRCC6 for ontologies About GeneDecksing
XRCC6 Antibody Products:
Assay Products for XRCC6: |
Protein
Domains /
Families
for XRCC6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XRCC6 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P12956ProtoNet protein and cluster: P12956 2 Blocks protein families: IPB003034 DNA-binding SAP IPB005160 Ku70/Ku80 C-terminal arm
UniProtKB/Swiss-Prot: XRCC6_HUMAN, P12956Similarity: Belongs to the ku70 familySimilarity: Contains 1 Ku domainSimilarity: Contains 1 SAP domain |
Function
for XRCC6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XRCC6_HUMAN, P12956Function: Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNAhelicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. Itworks in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining(NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunitof the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. Theassembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin geneexpression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing thebeta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activityallows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks,before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator oftranscriptionInduction: In osteoblasts, by FGF2Enzyme Numbers (IUBMB): EC 4.2.99.-1 EC 3.6.4.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XRCC6 (NM_001469) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC6 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
XRCC6 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for XRCC6:
Animal Models:
Mouse knock-outs for XRCC6: Xrcc6tm1Fwa Xrcc6tm1Gcl
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Xrcc6):
XRCC6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for XRCC6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Non-homologous end-joining | | | 2 | Plus-strand DNA synthesis | | | 3 | Processing of DNA ends prior to end rejoining | | | 4 | Cell Cycle / Checkpoint Control | | | 5 | HIV Infection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for XRCC6
1 
Cell Signaling Technology (CST) Pathway for XRCC6
1  GeneGo (Thomson Reuters) Pathway for XRCC6
5  BioSystems Pathways for XRCC6
5/10 
Reactome Pathways for XRCC6 (see all 10)
1 
Kegg Pathway (Kegg details for XRCC6):
XRCC6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XRCC6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/922 Interacting proteins for XRCC6 (P129561, 2, 3 ENSP000003522574) via UniProtKB, MINT, STRING, and/or I2D (see all 922)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
XRCC6 for ontologies About GeneDecksing
|
Drugs & Compounds
for XRCC6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
XRCC6 for compounds About GeneDecksing
 Browse Tocris compounds for XRCC6
10/14 Novoseek chemical compound relationships for XRCC6 gene (see all 14) About this table
Search CenterWatch for drugs/clinical trials and news about XRCC6
|
Transcripts
for XRCC6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XRCC6 gene: NM_001469.3 Unigene Cluster for XRCC6: X-ray repair complementing defective repair in Chinese hamster cells 6 Hs.292493 [show with all ESTs]Unigene Representative Sequence: BC0083439 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360079(uc003bao.1 uc003bap.1 uc011apc.1) ENST00000464116
ENST00000402580 ENST00000359308(uc003bar.2) ENST00000405878 ENST00000402409
ENST00000405506 ENST00000478914 ENST00000428575
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XRCC6 (NM_001469) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC6 |
Additional cDNA sequence: AF052148.1 AK055786.1 AK293439.1 AK304580.1 AK315618.1 BC001583.1 BC008343.1 BC010034.2 BC012154.2 BC018259.2 BC072449.1 CR456492.1 CR542219.1 J04607.1 J04611.1 M32865.1 S38729.1 24/103 DOTS entries (see all 103): DT.97801829 DT.100891260 DT.91936042 DT.92002298 DT.40237757 DT.100891297 DT.100891332 DT.100891263 DT.100836467 DT.100753842 DT.100891284 DT.91648729 DT.97868396 DT.120633317 DT.95236564 DT.91893522 DT.100891236 DT.92353827 DT.120633509 DT.120633355 DT.100891303 DT.100891296 DT.100891329 DT.100891321 24/2465 AceView cDNA sequences (see all 2465): BU195237 AU126178 CB149650 BX397659 BU684181 AA223415 BU189528 BE298064 BQ712593 BQ225713 CB143508 BG282152 AI368699 BM552696 BU159811 BQ215732 BG939179 AU135790 BP357616 BX411071 AI686135 BM852817 CR598672 BM744933
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC6 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for XRCC6
|
Expression
for XRCC6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XRCC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGATGGTGT
About this image
See XRCC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XRCC6
SOURCE GeneReport for Unigene cluster: Hs.292493
SABiosciences Expression via Pathway-Focused PCR Arrays including XRCC6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRCC6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XRCC6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC6 |
Orthologs
for XRCC6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for XRCC6 gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for XRCC6 (if available)
TreeFam Gene Tree for XRCC6 (if available) |
Paralogs
for XRCC6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XRCC6 gene
1 SIMAP similar gene for XRCC6 using alignment to 4 protein entries: XRCC6_HUMAN (see all proteins):G22P1
XRCC6 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for XRCC6
PGOHUM00000238588 PGOHUM00000244427 PGOHUM00000260407 PGOHUM00000241459 PGOHUM00000241596
|
Genomic Variants
for XRCC6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XRCC6 (42017123 - 42060052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for XRCC6: --
Human Gene Mutation Database (HGMD): XRCC6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRCC6 |
|
Disorders
/ Diseases
for XRCC6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XRCC6 for disorders About GeneDecksing
OMIM gene information: 152690
OMIM disorders: --
20/57  diseases for XRCC6 (see all 57): About MalaCardssystemic lupus erythematosus lupus erythematosus thyroiditis malignant pleural mesothelioma
ataxia telangiectasia connective tissue disease bloom syndrome oral squamous cell carcinoma
squamous cell carcinoma sporadic breast cancer chronic lymphocytic leukemia herpes simplex
epithelial ovarian cancer lymphocytic leukemia werner syndrome myeloid leukemia
pterygium lung cancer susceptibility multiple myeloma cervical cancer
2 diseases from the University of Copenhagen DISEASES database for XRCC6:Cancer Werner syndrome 10/18 Novoseek disease relationships for XRCC6 gene (see all 18) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bloom syndrome |
51.1 |
1 |
15184650 (1) |
| ataxia telangiectasia |
49.9 |
3 |
12210072 (3) |
| nsclc |
22.2 |
2 |
15273727 (1), 19826407 (1) |
| cancer |
19.9 |
6 |
17982634 (4), 12698192 (1), 15205359 (1) |
| tumors |
16.9 |
38 |
12810658 (5), 18546291 (5), 16029807 (4), 15254745 (3) (see all 12) |
| myeloid leukemia |
14.2 |
3 |
12019155 (1), 12702565 (1) |
| colon cancer |
5.48 |
3 |
15205359 (2), 11731412 (1) |
| carcinoma |
5.48 |
4 |
16827151 (3), 11104569 (1) |
| colon carcinoma |
2.18 |
1 |
15827325 (1) |
| colorectal cancer |
2.02 |
4 |
15254745 (2), 16533773 (1), 17071631 (1) |
Genetic Association Database (GAD): XRCC6
Human Genome Epidemiology (HuGE) Navigator: XRCC6 (30 documents)
Export disorders for XRCC6 gene to outside databases
|
Publications
for XRCC6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XRCC6 gene, integrated from 9 sources (see all 431):
(articles sorted by number of sources associating them with XRCC6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. (PubMed id 9362500)1, 2, 9 Jin S. and Weaver D.T. (1997)
- The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70. (PubMed id 11457852)1, 2, 9 Zhang Z.... Chen Y. (2001)
- Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PubMed id 15075319)1, 2, 9 Wang H.... Oettgen P. (2004)
- Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility. (PubMed id 12750264)1, 4, 9 Fu Y.P....Shen C.Y. (2003)
- Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. (PubMed id 12145306)1, 2, 9 Willis D.M.... Towler D.A. (2002)
- DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. (PubMed id 10026262)1, 2, 9 Chan D.W.... Lees-Miller S.P. (1999)
- Ku is a 5'-dRP/AP lyase that excises nucleotide damag e near broken ends. (PubMed id 20383123)1, 2 Roberts S.A....Ramsden D.A. (2010)
- 55K isoform of CDK9 associates with Ku70 and is invol ved in DNA repair. (PubMed id 20493174)1, 2 Liu H....Rice A.P. (2010)
- Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. (PubMed id 15958648)1, 4 Lee K.M....Kang D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
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External Searches for XRCC6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing XRCC6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing XRCC6 gene
(According to HUGE)
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Specialized Databases showing XRCC6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for XRCC6 gene:
Search GeneIP for patents involving XRCC6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for XRCC6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for XRCC6 | | OriGene shRNA RFP for XRCC6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XRCC6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRCC6 | | | OriGene Protein Over-expression Lysate for XRCC6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XRCC6 | | OriGene 3'-UTR Clone for XRCC6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for XRCC6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XRCC6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRCC6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRCC6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC6 |
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| | Antibodies & Assays for XRCC6 (Ku70) |
| | | | Search Tocris compounds for XRCC6 |
| |  |  |  |  | | | | | | Recombinant Protein for XRCC6 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC6 |
|  |  |  | | | | ThermoFisher Antibody for XRCC6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC6 |
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