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XRCC5 Gene

protein-coding   GIFtS: 69

GC02P216680
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
(Previous names: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for XRCC5

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CTC85 3
CTCBF 3
EC 3.6.1.- 3
FLJ39089 2
G22P2 3
KARP-1 1, 2
KARP1 2
KU80 1, 2
KUB2 1, 2
Ku80 3
Ku86 1, 2, 3
NFIV 2
TLAA 3
Descriptions
86 kDa subunit of Ku antigen 3
ATP-dependent DNA helicase II 2
ATP-dependent DNA helicase II 80 kDa subunit 3
CTC box-binding factor 85 kDa subunit 3
DNA repair protein XRCC5 2, 3
Ku autoantigen, 80kDa 2
Ku86 autoantigen related protein 1 2
Lupus Ku autoantigen protein p86 3
Nuclear factor IV 3
Thyroid-lupus autoantigen 3
X-ray repair complementing defective repair in Chinese
hamster cells 5 (double-strand-break rejoining) 2
X-ray repair complementing defective repair in Chinese
hamster cells 5 (double-strand-break rejoining; Ku
autoantigen, 80kD) 1, 2
X-ray repair, complementing defective, repair in Chinese
hamster 2
External Ids
HGNC: 128331
Entrez Gene: 75202
UniProtKB: P130103
Ensembl: ENSG000000792467
Search outside databases for aliases for XRCC5 gene

Previous GC identifers: GC02P215135 GC02P215696 GC02P216938 GC02P217174 GC02P217152 GC02P216797

Summaries
for XRCC5

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for XRCC5:
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which
is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding
component of the DNA-dependent protein kinase, and it functions together with the DNA ligase
IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the
completion of V(D)J recombination events. This gene functionally complements Chinese hamster
xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J
recombination. A rare microsatellite polymorphism in this gene is associated with cancer in
patients of varying radiosensitivity. [provided by RefSeq]

UniProtKB/Swiss-Prot: KU86_HUMAN, P13010
Function: Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome
translocation. The DNA helicase II complex binds preferentially to fork-like ends of
double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to
DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for
double-strand break repair and V(D)J recombination. The Ku p70/p86 dimer acts as regulatory
subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the
catalytic subunit PRKDC to DNA by 100-fold. The Ku p70/p86 dimer is probably involved in
stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA
ends is required for the NHEJ ligation step. In association with NARG1, the Ku p70/p86 dimer binds
to the osteocalcin promoter and activates osteocalcin expression

Gene Wiki entry for XRCC5 (ATP-dependent_DNA_helicase_2_subunit_2)

Genomic Location
for XRCC5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XRCC5 gene  

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

XRCC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P216680:     (about GC identifiers)

Start:
 216,675,717 bp from pter
End:
 216,779,248 bp from pter
Size:
 103,532 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  

Proteins
for XRCC5

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: KU86_HUMAN, P13010 (See protein sequence)
Recommended Name: ATP-dependent DNA helicase 2 subunit 2  
Size: 732 amino acids; 82705 Da
Subunit: Heterodimer of a 70 kDa and a 80 kDa subunit. The dimer associates in a DNA-dependent
manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4
complex. The dimer also associates with NARG1, and this complex displays DNA binding activity
towards the osteocalcin FGF response element (OCFRE). In addition, the 80 kDa subunit binds to the
osteoblast-specific transcription factors MSX2 and RUNX2. Interacts with ELF3. May interact with
APLF
Subcellular location: Nucleus
Developmental stage: Expression increases during promyelocyte differentiation
PDB structures from and Proteopedia :
1JEQ (3D)    1JEY (3D)    1Q2Z (3D)    1RW2 (3D)    
Secondary accessions: A8K3X5 Q0Z7V0 Q4VBQ5 Q53HH7 Q7M4N0 Q9UCQ0 Q9UCQ1

Post-translational modifications:

  • Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity1
  • Sumoylated1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_066964.1  

    ENSEMBL proteins: 
    ENSP00000295663 ENSP00000329528 ENSP00000375978 ENSP00000375977 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Ku70 + Ku80, Ku80)
    Human Recombinant Proteins from Abnova (XRCC5)
                  OriGene Purified Recombinant Human Protein: XRCC5 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000783 nuclear telomere cap complex TAS15100233
    GO:0005634 nucleus TAS7957065
    GO:0005654 nucleoplasm EXP12023295 12065431
    About this table

    Antibodies for XRCC5: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of XRCC5
    Sigma-Aldrich Antibodies for XRCC5
    R&D Systems Antibodies for XRCC5 (Ku80/XRCC5)
    Cell Signaling Technology (CST) Antibodies for XRCC5  (Ku80)
    Antibodies from Abcam (Ku70 + Ku80, Ku80), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (XRCC5)
    Novus Biologicals Antibodies for XRCC5

    Assays for XRCC5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for XRCC5

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro domains/families:
     IPR005160 Ku_C
     IPR014893 Ku_PK_bind
     IPR005161 Ku_N
     IPR006164 DNA_helicase_ATP-dep_Ku
     IPR002035 VWF_A


       GeneDecks  XRCC5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P13010

    ProtoNet protein and cluster: P13010

    1 Blocks protein family: IPB005160 Ku70/Ku80 C-terminal arm

    UniProtKB/Swiss-Prot: KU86_HUMAN, P13010
    Domain: The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its
    recruitment to sites of DNA damage
    Similarity: Belongs to the ku80 family
    Similarity: Contains 1 Ku domain

    Gene Function
    for XRCC5

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (XRCC5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XRCC5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021141

                  Applied Biosystems Silencer® siRNAs for XRCC5

                  Sigma-Aldrich siRNA and siRNA Panels for XRCC5  
                         Sigma-Aldrich shRNA Panels and shRNA for XRCC5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for XRCC5
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021141
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021141
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_021141 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_021141

    UniProtKB/Swiss-Prot: KU86_HUMAN, P13010
    Function: Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome
    translocation. The DNA helicase II complex binds preferentially to fork-like ends of
    double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to
    DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for
    double-strand break repair and V(D)J recombination. The Ku p70/p86 dimer acts as regulatory
    subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the
    catalytic subunit PRKDC to DNA by 100-fold. The Ku p70/p86 dimer is probably involved in
    stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA
    ends is required for the NHEJ ligation step. In association with NARG1, the Ku p70/p86 dimer binds
    to the osteocalcin promoter and activates osteocalcin expression
    Induction: In osteoblasts, by FGF2
    Enzyme Number (IUBMB): EC 3.6.1.- 

    Genatlas biochemistry entry for XRCC5:
    repair X-ray defect,complementing defect in CHO cells,5,involved in double-strand DNA break
    rejoining

    15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Xrcc5):

    behavior/neurologicalcellulardigestive/alimentarygrowth/sizehematopoietic system
    homeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatallife span-post-weaning/aging
    nervous systemreproductive systemrespiratory systemtumorigenesisvision/eye

    5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003677 DNA binding NAS1537839
    GO:0003691contributes to double-stranded telomeric DNA binding IDA10409678
    GO:0004003 ATP-dependent DNA helicase activity TAS7957065
    GO:0004386 helicase activity IEA--
    About this table

    Pathways & Interactions
    for XRCC5

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for XRCC5
     DNA damage NHEJ mechanisms of DSBs repair

       GeneDecks  XRCC5 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for XRCC5):
     hsa03450 Non-homologous end-joining

       GeneDecks  XRCC5 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  XRCC5 


    5/70 Interacting proteins for XRCC5 (P130101, 2 ENSP000003295283) via UniProtKB, MINT, and/or STRING (see all 70 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLFQ8IW192, ENSP000003070043MINT-4790250 MINT-4790124 MINT-4790303 STRING (score=.776)
    XRCC4Q134262, ENSP000003420113MINT-6175948 MINT-6175964 STRING (score=.994)
    PRKDCP785272, ENSP000003134203MINT-4790124 STRING (score=.999)
    PARP1P098742, ENSP000003557593MINT-4790124 STRING (score=.898)
    HOXB7P096291, ENSP000002391653EBI-357997, EBI-1248457 STRING (score=.722)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723 telomere maintenance TAS15824061
    GO:0006303 double-strand break repair via nonhomologous end joining IEA--
    GO:0006974 response to DNA damage stimulus IEA--
    GO:0019047 provirus integration EXP16291214
    GO:0019059 initiation of viral infection EXP12091904
    About this table

    Drugs & Compounds
    for XRCC5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XRCC5
    5 Novoseek chemical compound relationships for XRCC5 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    p-350 84.02 3 8538653 (2), 7724535 (1)
    threonine 45.72 2 11376007 (1), 14556663 (1)
    okadaic acid 11.15 3 15941674 (2), 11376007 (1)
    oligonucleotide 0.00 2 12384553 (1), 15470482 (1)
    nacl 0.00 2 11175667 (1)
    About this table


    Transcripts
    for XRCC5

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (XRCC5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XRCC5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021141

                  Sigma-Aldrich siRNA and siRNA Panels for XRCC5  
                         Sigma-Aldrich shRNA Panels and shRNA for XRCC5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_021141  

    REFSEQ mRNAs for XRCC5 gene: 

    NM_021141.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_021141  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021141
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021141
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_021141 

    Additional cDNA sequence: 

    AK023296.1 AK026166.1 AK096408.1 AK222603.1 AK290740.1 BC019027.2 BC095442.1 BX647578.1 
    CR599959.1 CR615055.1 CR625379.1 J04977.1 M30938.1 X57500.1 

    24/53 DOTS entries (see all 53 ):

    DT.95145993  DT.97800488  DT.95171313  DT.100691454  DT.100691471  DT.100869880  DT.100691449  DT.95171318 
    DT.100691468  DT.92466638  DT.95171296  DT.100691456  DT.453635  DT.40225001  DT.100691470  DT.92466637 
    DT.97793901  DT.121019322  DT.95171297  DT.95171305  DT.425181  DT.92466640  DT.92466647  DT.92466665 

    24/1155 AceView cDNA sequences (see all 1155 ):

    AA167075 AU131795 BE890000 BC008604 AW249915 AI568805 AU155518 BQ642849 
    AU132244 AX747073 CA419334 CB131487 CB216035 AI168677 AI380119 AA333693 
    BM672147 AA577675 AU280621 CF265072 AW291087 BQ220595 AU123477 CA417688 

    highest scoring ESTs for XRCC5:

    J04977 M30938 AA079672 AA102740 AA113220 AA113390 AA126630 AA127009 AA132890 AA137248 

    Unigene Cluster for XRCC5:

    X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
    Hs.388739  [show with all ESTs]
    Unigene Representative Sequence: BX647578


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC5 (see all 8 )

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
    SP1:                                      -                 -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                -     -                 -                                                                                                   
    SP4:                                                        -                                                                                                   
    SP5:                                                                                                                                      -     -               

    ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for XRCC5

    4 Ensembl transcripts including schematic representations:
    ENST00000295663  ENST00000328063  ENST00000392133  ENST00000392132  

    Expression
    for XRCC5

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XRCC5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XRCC5

    1 / 2 / 3

    8 probe-sets matching XRCC5 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		2093_s_at2, 3 U95-A 1 1.00 1.00 0.77 0.99 J04977 1.00 1.00 1.00 1

    		38733_at2, 3 U95-A 1 1.00 1.00 0.85 1.12 M30938 1.00 1.00 1.00 1

    		584_s_at2, 3 U95-A 1 1.00 1.00 0.50 0.86 M30938 1.00 1.00 1.00 1

    		585_at2, 3 U95-A 1 1.00 1.00 0.89 1.03 M30938 1.00 1.00 1.00 1

    		208643_s_at2, 3 U133-A 1 1.00 1.00 -- -- J04977 1.00 1.00 1.00 1

    		208642_s_at2, 3 U133-A 1 1.00 1.00 -- -- AA205834 0.60 1.00 0.82 1

    		208643_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		208642_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TAACATTAAA

    SOURCE GeneReport for Unigene cluster: Hs.388739

    Expression variation in blood from EXPOLDB for XRCC5

    Orthologs
    for XRCC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for XRCC5 gene from 5/16 species (see all 16 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 XRCC51   -- X-ray repair complementing defective repair in Chinese more 87.04(n)
    82.55(a)    		 478902  XM_536061.2  XP_536061.2 
    chimpanzee
    (Pan troglodytes)    		 XRCC51   -- X-ray repair complementing defective repair in Chinese more 99.77(n)
    99.73(a)    		 449614  XM_001151933.1  XP_001151933.1 
    cow
    (Bos taurus)    		 XRCC51   -- X-ray repair complementing defective repair in Chinese more 87.96(n)
    81.4(a)    		 531945  XM_610450.3  XP_610450.3 
    rat
    (Rattus norvegicus)    		 Xrcc51   -- X-ray repair complementing defective repair in Chinese more 83.58(n)
    78.39(a)    		 363247  NM_177419.1  NP_803154.1 
    mouse
    (Mus musculus)    		 Xrcc51, 5 1 (42.00 cM)5
    		 X-ray repair complementing defective repair in Chinese more1, 5 83.4(n)1
    77.84(a)1    		 225961  NM_009533.11  NP_033559.11 
     AF1664865  AI3140155  (see all 22)
    About this table        Species with no ortholog for XRCC5

    ENSEMBL Gene Tree for XRCC5

    Paralogs
    for XRCC5

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for XRCC5

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/870 NCBI SNPs in XRCC5 are shown (see all 870 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 217)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs69411,2
    		A,C,F,H216778897(+) AAACTC/AAAAAA 1 -- ut3119Minor allele frequency- A:0.21MN CSAM EA EU WA NA NS 1518
    rs10516851,2
    		A,C,F,H216778621(+) TCACAA/GCTTGT 1 -- ut31 ese315Minor allele frequency- G:0.15MN CSAM EA EU WA NS 1198
    --
    rs116853871,2
    		A,C,F,H216682059(+) ACTAGC/TGTTTC 1 -- ng519Minor allele frequency- T:0.45EU EA WA NS 596
    --
    rs23727671,2
    		C,F,H216682135(+) GGAATC/GTGCGC 1 -- ng512Minor allele frequency- G:0.05EA 144
    rs10516771,2
    		C,F,H216778493(+) CCTAGT/CATATC 1 -- ut31 ese327Minor allele frequency- C:0.14EA MN CSAM NA EU WA NS 3676
    rs24401,2
    		A,C,F216779011(-) AAAGAC/TCGAAA 1 -- ut3115Minor allele frequency- T:0.37MN CSAM EA NA NS 1112
    rs18038821,2
    		C,F,H216778813(+) TCCTTT/ATAAGC 1 -- ut3121Minor allele frequency- A:0.02MN CSAM EA NA EU WA NS 1572
    rs8289071,2
    		A,C,F216680977(+) AGGGCG/TAGTGT 1 -- ng517Minor allele frequency- T:0.33NA NS 348
    --
    rs362185931,2
    		C,F216681151(+) ATATGT/CCTGAC 1 -- ng515Minor allele frequency- C:0.09NS 168
    rs18053801,2
    		C,H216714200(+) AGCTTG/CGCAAA 1 F/L mis16Minor allele frequency- C:0.00NA MN EU EA WA 696
    About this table

    HapMap Linkage Disequilibrium images for XRCC5 (up to first 250kb)

    Disorders & Mutations
    for XRCC5

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 194364

    UniProtKB/Swiss-Prot: KU86_HUMAN, P13010
  • Individuals with systemic lupus erythematosus (SLE) and related disorders produce
    extremely large amounts of autoantibodies to p70 and p86

    • 10/23 Novoseek disease relationships for XRCC5 gene (see all 23 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 54.44 4 9636207 (3)
    werner syndrome 46.69 1 19372586 (1)
    chromosomal aberrations 41.91 4 12460917 (3), 15492246 (1)
    myeloid leukemia 27.24 2 12019155 (1), 12702565 (1)
    colon carcinoma 24.96 3 11152960 (2), 15208076 (1)
    cancer 22.32 11 17982634 (4), 15492246 (1), 15827325 (1), 12460917 (1) (see all 8)
    tumors 22.04 38 15254745 (3), 12902903 (3), 18546291 (3), 12216085 (2) (see all 15)
    nsclc 17.93 3 17289874 (2)
    colon cancer 14.14 2 11731412 (1), 11792868 (1)
    carcinoma squamous cell 13.04 2 14556663 (1), 17289874 (1)
    About this table

    Human Gene Mutation Database: XRCC5
    Genetic Association Database: XRCC5
    Human Genome Epidemiology Navigator: XRCC5 (20 documents)

    Medical News
    for XRCC5

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for XRCC5

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/283 PubMed articles for XRCC5 gene (see all 283 ):

    Search for XRCC5

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing XRCC5

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 7520 HGNC: 12833 AceView: XRCC5 Ensembl:ENSG00000079246 euGenes: HUgn7520
    ECgene: XRCC5 H-InvDB: XRCC5

    Other Databases showing XRCC5

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing XRCC5

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for XRCC5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS SNPshttp://egp.gs.washington.edu/data/xrcc5/

    Licensable Technologies
    for XRCC5

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for XRCC5

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XRCC5:
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     Antibodies & Assays for XRCC5  (Ku80)

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     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for XRCC5




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for XRCC5

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