XRCC5 Gene
protein-coding GIFtS: 63
GCID: GC02P216972
|
|
X-ray repair complementing defective repair in Chinese hamster...(Previous names: X-ray repair complementing defective repair in Chinese...)
| |
Aliases
for XRCC5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 5(Double-Strand-Break Rejoining)1 2 3 | | ATP-Dependent DNA Helicase II 80 KDa Subunit2 3 | | Ku861 2 3 | | CTC Box-Binding Factor 85 KDa Subunit2 3 | | KARP-11 2 | | DNA Repair Protein XRCC52 3 | | KU801 2 | | X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 5(Double-Strand-Break Rejoining; Ku Autoantigen, 80kD)1 | | KUB21 2 | | KARP12 | | Lupus Ku Autoantigen Protein P862 3 | | NFIV2 | | Nuclear Factor IV2 3 | | Ku Autoantigen, 80kDa2 | | Thyroid-Lupus Autoantigen2 3 | | Ku86 Autoantigen Related Protein 12 | | 86 KDa Subunit Of Ku Antigen2 3 | | X-Ray Repair Cross-Complementing Protein 52 | | CTC852 3 | | EC 3.6.4.-3 | | CTCBF2 3 | | G22P23 | | TLAA2 3 | | Ku803 | | ATP-Dependent DNA Helicase 2 Subunit 22 3 | | |
Export aliases for XRCC5 gene to outside databasesPrevious GC identifers: GC02P215135 GC02P215696 GC02P216938 GC02P217174 GC02P217152 GC02P216797 GC02P216680 GC02P208831 |
Summaries
for XRCC5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XRCC5:
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known asATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependentprotein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strandbreak by non-homologous end joining and the completion of V(D)J recombination events. This gene functionallycomplements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergoV(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varyingradiosensitivity. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: XRCC5_HUMAN, P13010Function: Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNAhelicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. Itworks in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining(NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunitof the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. Theassembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, theXRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably alsoacts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5'deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associatedwith strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negativeregulator of transcription
Gene Wiki entry for XRCC5 (Ku80)
|
Genomic Views
for XRCC5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XRCC5 gene promoter:
Sp1 p53 p300 CUTL1 LCR-F1 C/EBPalpha MEF-2A PPAR-alpha Nkx6-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for XRCC5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35XRCC5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P216972: view genomic region
(about GC identifiers)
Start:
|
216,972,187 bp from pter |
End:
|
217,071,026 bp from pter |
Size:
|
98,840 bases |
Orientation:
|
plus strand |
|
Proteins
for XRCC5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XRCC5_HUMAN, P13010 (See
protein sequence)Recommended Name: X-ray repair cross-complementing protein 5 Size: 732 amino acids; 82705 Da
Subunit: Heterodimer of a 70 kDa and a 80 kDa subunit. The dimer associates in a DNA-dependent manner with PRKDC toform the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex. The dimer also associates withNAA15, and this complex displays DNA binding activity towards the osteocalcin FGF response element (OCFRE). Inaddition, the 80 kDa subunit binds to the osteoblast-specific transcription factors MSX2 and RUNX2. Interacts withELF3. May interact with APLF. The XRCC5/6 dimer associates in a DNA-dependent manner with APEX1
Subcellular location: Nucleus. Nucleus, nucleolus. Chromosome
Developmental stage: Expression increases during promyelocyte differentiation
Miscellaneous: Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely largeamounts of autoantibodies to XRCC6 and XRCC5
5 PDB 3D structures from  and Proteopedia  for XRCC5:1JEQ (3D)
1JEY (3D)
1Q2Z (3D)
1RW2 (3D)
3RZ9 (3D)
Secondary accessions: A8K3X5 Q0Z7V0 Q4VBQ5 Q53HH7 Q7M4N0 Q9UCQ0 Q9UCQ1Explore the universe of human proteins at neXtProt for XRCC5: NX_P13010
Post-translational modifications:
Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity1
Sumoylated1
Ubiquitinated by RNF8 via 'Lys-48'-linked ubiquitination following DNA damage, leading to its degradation and removalfrom DNA damage sites1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13010
XRCC5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066964.1
ENSEMBL proteins: ENSP00000375978 ENSP00000401318 ENSP00000395108 ENSP00000375977 Reactome Protein details: P13010
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
XRCC5 for ontologies About GeneDecksing
XRCC5 Antibody Products:
Assay Products for XRCC5: |
Protein
Domains /
Families
for XRCC5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XRCC5 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P13010ProtoNet protein and cluster: P13010 1 Blocks protein family: IPB005160 Ku70/Ku80 C-terminal arm
UniProtKB/Swiss-Prot: XRCC5_HUMAN, P13010Domain: The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites ofDNA damageSimilarity: Belongs to the ku80 familySimilarity: Contains 1 Ku domain |
Function
for XRCC5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XRCC5_HUMAN, P13010Function: Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNAhelicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. Itworks in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining(NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunitof the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. Theassembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, theXRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably alsoacts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5'deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associatedwith strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negativeregulator of transcriptionInduction: In osteoblasts, by FGF2 Genatlas biochemistry entry for XRCC5:repair X-ray defect,complementing defect in CHO cells,5,involved in double-strand DNA break rejoining
Enzyme Number (IUBMB): EC 3.6.4.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XRCC5 (NM_021141) | |  | Sino Biological Human cDNA Clone for XRCC5 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC5 |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
XRCC5 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for XRCC5: Xrcc5tm1Nus Xrcc5tm1Dbr
13 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Xrcc5):
XRCC5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for XRCC5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Non-homologous end-joining | | | 2 | Plus-strand DNA synthesis | | | 3 | Processing of DNA ends prior to end rejoining | | | 4 | Lymphocyte Signaling | | | 5 | DNA Damage | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for XRCC5
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for XRCC5
3 
Cell Signaling Technology (CST) Pathways for XRCC5
1  GeneGo (Thomson Reuters) Pathway for XRCC5
4  BioSystems Pathways for XRCC5
5/10 
Reactome Pathways for XRCC5 (see all 10)
1 
Kegg Pathway (Kegg details for XRCC5):
XRCC5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XRCC5
5/183 Interacting proteins for XRCC5 (P130101, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 183)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
XRCC5 for ontologies About GeneDecksing
|
Drugs & Compounds
for XRCC5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
XRCC5 for compounds About GeneDecksing
 Browse Tocris compounds for XRCC5
10/13 Novoseek chemical compound relationships for XRCC5 gene (see all 13) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| p-350 |
83.3 |
3 |
8538653 (2), 7724535 (1) |
| bleomycin |
46.5 |
4 |
12384553 (3), 11086072 (1) |
| threonine |
44.2 |
2 |
11376007 (1), 14556663 (1) |
| serine |
38 |
3 |
11376007 (1), 14556663 (1), 10026262 (1) |
| cisplatin |
31.6 |
9 |
18415044 (3), 19372586 (2), 12384553 (1), 16230379 (1) (see all 6) |
| mitomycin c |
20.1 |
1 |
11086072 (1) |
| camptothecin |
14.6 |
3 |
16230379 (2), 17596214 (1) |
| etoposide |
13.9 |
5 |
12384553 (3), 16230379 (1), 17596214 (1) |
| melphalan |
11.4 |
1 |
10717383 (1) |
| okadaic acid |
9.78 |
3 |
15941674 (2), 11376007 (1) |
Search CenterWatch for drugs/clinical trials and news about XRCC5
|
Transcripts
for XRCC5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XRCC5 gene: NM_021141.3 Unigene Cluster for XRCC5: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Hs.388739 [show with all ESTs]Unigene Representative Sequence: BX64757810 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392133(uc002vfy.3 uc002vfz.3) ENST00000429133 ENST00000476360
ENST00000417391 ENST00000451695 ENST00000460284 ENST00000493706 ENST00000471649
ENST00000485763 ENST00000392132
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XRCC5 (NM_021141) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC5 |
Additional cDNA sequence: AK023296.1 AK026166.1 AK096408.1 AK222603.1 AK290740.1 BC019027.2 BC095442.1 BX647578.1 J04977.1 M30938.1 X57500.1 24/54 DOTS entries (see all 54): DT.95145993 DT.97800488 DT.95171313 DT.100691454 DT.100691471 DT.100869880 DT.100691449 DT.95171318 DT.100691468 DT.92466638 DT.100691456 DT.95171296 DT.453635 DT.100691470 DT.40225001 DT.92466637 DT.121019322 DT.92466647 DT.95171297 DT.95171305 DT.92466640 DT.92466665 DT.95171314 DT.97793901 24/1155 AceView cDNA sequences (see all 1155): AA308933 BQ440253 BX415043 AA132890 CA441844 AA353707 CA447224 BM451420 BM988433 CR625379 NM_138390 D55836 BU177743 CA417688 BG393556 BM789429 AA227267 CB118207 CA420113 AU131608 BU153133 AA343992 AI799981 CB131487
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC5 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | |
| ExUns: | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for XRCC5
|
Expression
for XRCC5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XRCC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACATTAAA
About this image
See XRCC5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XRCC5
SOURCE GeneReport for Unigene cluster: Hs.388739
SABiosciences Expression via Pathway-Focused PCR Arrays including XRCC5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRCC5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XRCC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC5 |
Orthologs
for XRCC5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for XRCC5 gene from 9/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Xrcc51 , 5 |
X-ray repair complementing defective repair in Chinese more1, 5 |
83.81(n)1
78.52(a)1 |
|
1 (36.50 cM)5
225961 NM_009533.21 NP_033559.21
723074215 |
chicken
(Gallus gallus) |
Aves |
XRCC51 |
X-ray repair complementing defective repair in Chinese more |
69.88(n)
66.8(a) |
|
424222 XM_422072.3 XP_422072.3 |
lizard
(Anolis carolinensis) |
Reptilia |
XRCC56 |
-- |
65(a) |
1 ↔ 1 |
GL343344.1(960843-1021758) |
African clawed frog
(Xenopus laevis) |
Amphibia |
xrcc5-A-prov2 |
X-ray repair complementing defective repair in Chinese more |
72.43(n) |
|
AB020609.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.102812 |
Transcribed sequence with weak similarity to protein more |
75.74(n) |
|
CK026935.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ku806 |
Ku80 |
19(a) |
1 ↔ 1 |
2L(15768630-15771159) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
YKU801 |
Yku80p |
-- |
|
855132 NP_013824.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
KU801 |
ATP-dependent DNA helicase 2 subunit KU80 |
45.38(n)
28.62(a) |
|
841223 NM_103701.1 NP_564520.1 |
rice
(Oryza sativa) |
Liliopsida |
-- |
KAP-2, putative, expressed |
23(a) |
1 ↔ 1 |
3(36106946-36112647) |
ENSEMBL Gene Tree for XRCC5 (if available)
TreeFam Gene Tree for XRCC5 (if available) |
Paralogs
for XRCC5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for XRCC5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XRCC5 (216972187 - 217071026 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for XRCC5: --
Human Gene Mutation Database (HGMD): XRCC5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRCC5 |
|
Disorders
/ Diseases
for XRCC5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XRCC5 for disorders About GeneDecksing
OMIM gene information: 194364
OMIM disorders: --
20/67  diseases for XRCC5 (see all 67): About MalaCardsdna ligase iv deficiency human t-cell leukemia virus type 1 tinea capitis dna topoisomerase i
thyroiditis ataxia telangiectasia squamous cell carcinoma chronic obstructive pulmonary disease
werner syndrome oral squamous cell carcinoma malignant glioma esophageal squamous cell carcinoma
systemic lupus erythematosus myeloid leukemia lupus erythematosus breast cancer susceptibility
bladder cancer susceptibility chronic lymphocytic leukemia acute myeloid leukemia herpes simplex
10/23 Novoseek disease relationships for XRCC5 gene (see all 23) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ataxia telangiectasia |
56.2 |
4 |
9636207 (3) |
| werner syndrome |
45.1 |
1 |
19372586 (1) |
| chromosomal aberrations |
40.4 |
4 |
12460917 (3), 15492246 (1) |
| myeloid leukemia |
25.7 |
2 |
12019155 (1), 12702565 (1) |
| colon carcinoma |
23.3 |
3 |
11152960 (2), 15208076 (1) |
| tumors |
19.6 |
38 |
15254745 (3), 12902903 (3), 18546291 (3), 12216085 (2) (see all 15) |
| cancer |
19.5 |
11 |
17982634 (4), 15492246 (1), 15827325 (1), 12460917 (1) (see all 8) |
| nsclc |
15.1 |
3 |
17289874 (2) |
| colon cancer |
11.8 |
2 |
11731412 (1), 11792868 (1) |
| carcinoma squamous cell |
10.9 |
2 |
14556663 (1), 17289874 (1) |
Genetic Association Database (GAD): XRCC5
Human Genome Epidemiology (HuGE) Navigator: XRCC5 (42 documents)
Export disorders for XRCC5 gene to outside databases
|
Publications
for XRCC5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XRCC5 gene, integrated from 9 sources (see all 422):
(articles sorted by number of sources associating them with XRCC5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity. (PubMed id 9214634)1, 3, 9 Myung K.... Hendrickson E.A. (1997)
- KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion. (PubMed id 9636207)1, 3, 9 Myung K.... Hendrickson E.A. (1998)
- Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen. (PubMed id 7882982)1, 2, 9 Genersch E....Poeschl E. (1995)
- Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PubMed id 15075319)1, 2, 9 Wang H.... Oettgen P. (2004)
- Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. (PubMed id 15758953)1, 2, 9 Falck J.... Jackson S.P. (2005)
- Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility. (PubMed id 12750264)1, 4, 9 Fu Y.P....Shen C.Y. (2003)
- Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. (PubMed id 12145306)1, 2, 9 Willis D.M.... Towler D.A. (2002)
- DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. (PubMed id 10026262)1, 2, 9 Chan D.W.... Lees-Miller S.P. (1999)
- The E3 ligase RNF8 regulates KU80 removal and NHEJ rep air. (PubMed id 22266820)1, 2 Feng L. and Chen J. (2012)
- A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. (PubMed id 17396150)1, 2 Kanno S....Yasui A. (2007)
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External Searches for XRCC5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing XRCC5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing XRCC5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XRCC5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for XRCC5 gene:
Search GeneIP for patents involving XRCC5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XRCC5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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