XRCC4 Gene
protein-coding GIFtS: 64
GCID: GC05P082409
|
|
X-ray repair complementing defective repair in Chinese hamster...
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Aliases
for XRCC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 41 2 | | X-Ray Repair Cross-Complementing Protein 42 3 | | DNA Repair Protein XRCC42 | | X-Ray Repair, Complementing Defective, Repair In Chinese Hamster2 |
Export aliases for XRCC4 gene to outside databasesPrevious GC identifers: GC05P081191 GC05P082600 GC05P082412 GC05P082457 GC05P077581 |
Summaries
for XRCC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XRCC4:
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in therepair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. Thenon-homologous end-joining pathway is required both for normal development and for suppression of tumors. This genefunctionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaksproduced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicinggenerates several transcript variants. (provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426Function: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)Jrecombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligationstep, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent onthe assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends
Gene Wiki entry for XRCC4
|
Genomic Views
for XRCC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XRCC4 gene promoter:
STAT5B AML1a NRSF form 1 NRSF form 2 POU2F1 POU2F1b POU2F1a FOXO1a POU2F1c FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for XRCC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q14.2 Ensembl cytogenetic band: 5q14.2 HGNC cytogenetic band: 5q14.2XRCC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P082409: view genomic region
(about GC identifiers)
Start:
|
82,373,317 bp from pter |
End:
|
82,649,606 bp from pter |
Size:
|
276,290 bases |
Orientation:
|
plus strand |
|
Proteins
for XRCC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426 (See
protein sequence)Recommended Name: DNA repair protein XRCC4 Size: 336 amino acids; 38287 Da
Subunit: Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complexassociates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC.Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts withAPTX and APLF
Subcellular location: Nucleus
6/8 PDB 3D structures from  and Proteopedia  for XRCC4 (see all 8):1FU1 (3D)
1IK9 (3D)
3II6 (3D)
3MUD (3D)
3Q4F (3D)
3RWR (3D)
Secondary accessions: A8K3X4 Q9BS72 Q9UP94Alternative splicing: 3 isoforms: Q13426-1 Q13426-2 Q13426-3 Explore the universe of human proteins at neXtProt for XRCC4: NX_Q13426
Post-translational modifications:
Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA. Phosphorylation by CK2promotes interaction with APTX1
Monoubiquitinated1
Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no effect onubiquitination1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13426
XRCC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_003392.1 NP_071801.1 NP_072044.1
ENSEMBL proteins: ENSP00000342011 ENSP00000379344 ENSP00000421491 ENSP00000282268 Reactome Protein details: Q13426
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
XRCC4 for ontologies About GeneDecksing
XRCC4 Antibody Products:
Assay Products for XRCC4: |
Protein
Domains /
Families
for XRCC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XRCC4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13426ProtoNet protein and cluster: Q13426 UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426Similarity: Belongs to the XRCC4 family |
Function
for XRCC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426Function: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)Jrecombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligationstep, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent onthe assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends Genatlas biochemistry entry for XRCC4:repair X-ray defect,complementing defect in CHO cells,4 with CAG repeat,involved in DNA double-strand break repair byend joining (non homologous recombination) and V(D)J recombination. Also involved in neurogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): XRCC4 (NM_022406) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
XRCC4 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for XRCC4:
Animal Models:
Mouse knock-outs for XRCC4: Xrcc4tm1Fwa Xrcc4tm2.1Fwa
13 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Xrcc4):
XRCC4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for XRCC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Non-homologous end-joining | | | 2 | Plus-strand DNA synthesis | | | 3 | HIV Infection | | | 4 | Disease | | | 5 | Late Phase of HIV Life Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for XRCC4
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for XRCC4
1  GeneGo (Thomson Reuters) Pathway for XRCC4
1  BioSystems Pathway for XRCC4
5/9 
Reactome Pathways for XRCC4 (see all 9)
1 
Kegg Pathway (Kegg details for XRCC4):
XRCC4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XRCC4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/40 Interacting proteins for XRCC4 (Q134261, 2, 3 ENSP000003420114) via UniProtKB, MINT, STRING, and/or I2D (see all 40)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PNKP | Q96T602, 3, ENSP000003235114 | MINT-51171 MINT-8200112 MINT-51174 MINT-8200097 MINT-51172 MINT-8200126 MINT-51173 MINT-51175 I2D:
score=4 STRING: ENSP00000323511 | | NHEJ1 | Q9H9Q41, 2, 3, ENSP000003493134 | EBI-717592,EBI-847807 MINT-6175948 MINT-8094510 MINT-6175964 I2D:
score=3 STRING: ENSP00000349313 | | APTX | Q7Z2E32, 3, ENSP000004008064 | MINT-51155 MINT-2864227 MINT-51156 I2D:
score=3 STRING: ENSP00000400806 | | XRCC5 | P130102, 3 | MINT-6175948 MINT-8094510 MINT-6175964 I2D:
score=1 | | BIN1 | O004991, 3, ENSP000003167794 | EBI-717592,EBI-1965383 I2D:
score=2 STRING: ENSP00000316779 |
About this table
Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table
XRCC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for XRCC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
XRCC4 for compounds About GeneDecksing
 Browse Tocris compounds for XRCC4
1 DrugBank Compound for XRCC4 About this table
3 Novoseek chemical compound relationships for XRCC4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| polynucleotide |
56.3 |
3 |
18644470 (1), 17353262 (1), 15380105 (1) |
| wortmannin |
35.7 |
4 |
12140331 (4) |
| alanine |
13.7 |
1 |
14599745 (1) |
1 PharmGKB related drug/compound annotation for XRCC4 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about XRCC4
|
Transcripts
for XRCC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XRCC4 gene (3 alternative transcripts): NM_003401.3 NM_022406.2 NM_022550.2 Unigene Cluster for XRCC4: X-ray repair complementing defective repair in Chinese hamster cells 4 Hs.567359 [show with all ESTs]Unigene Representative Sequence: NM_0225506 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338635 ENST00000542685(uc003kia.1) ENST00000396027 ENST00000511817(uc003kig.3)
ENST00000509268 ENST00000282268(uc003kib.3 uc003kic.3 uc003kid.3 uc003kie.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): XRCC4 (NM_022406) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC4 |
Additional cDNA sequence: AB017445.1 AK290739.1 BC005259.1 BC010655.1 BC016314.1 BT007216.1 U40622.1 16 DOTS entries: DT.95269018 DT.40220026 DT.312131 DT.92436833 DT.120875805 DT.100819225 DT.120875672 DT.100819221 DT.101986016 DT.100819224 DT.100819223 DT.120875671 DT.40109549 DT.92436831 DT.92436832 DT.95269017 24/128 AceView cDNA sequences (see all 128): BX281210 AA314379 AI795996 CA394395 CB144620 BU171074 AL543920 AI270686 BM471375 AI289105 AL551668 CR602998 BX362079 AL558342 CR617390 CR599717 BE781259 BC005259 BM564730 BX279574 BG204714 BI760531 BQ226357 R39148
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for XRCC4
|
Expression
for XRCC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XRCC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTATAATTA
About this image
See XRCC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XRCC4
SOURCE GeneReport for Unigene cluster: Hs.567359
UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Arrays including XRCC4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRCC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XRCC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC4 |
Orthologs
for XRCC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for XRCC4 gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Xrcc41 , 5 |
X-ray repair complementing defective repair in Chinese more1, 5 |
81.08(n)1
76.07(a)1 |
|
13 (45.50 cM)5
1081381 NM_028012.41 NP_082288.11
897740275 |
chicken
(Gallus gallus) |
Aves |
XRCC41 |
X-ray repair complementing defective repair in Chinese more |
65.35(n)
53.6(a) |
|
427325 XM_424905.3 XP_424905.3 |
lizard
(Anolis carolinensis) |
Reptilia |
XRCC46 |
-- |
55(a) |
1 ↔ 1 |
2(18412520-18557775) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.321452 |
Xenopus laevis transcribed sequence with weak similarity more |
74.05(n) |
|
CD302243.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
xrcc41 |
X-ray repair complementing defective repair in Chinese more |
50.05(n)
40.92(a) |
|
393759 NM_200786.1 NP_957080.1 |
ENSEMBL Gene Tree for XRCC4 (if available)
TreeFam Gene Tree for XRCC4 (if available) |
Paralogs
for XRCC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for XRCC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XRCC4 (82373317 - 82623317 bp, first 250kb of XRCC4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for XRCC4
2 CNVs: 53729 51746
3 Indels: 43040 40777 62396
Human Gene Mutation Database (HGMD): XRCC4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRCC4 |
|
Disorders
/ Diseases
for XRCC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XRCC4 for disorders About GeneDecksing
OMIM gene information: 194363
OMIM disorders: --
20/66  diseases for XRCC4 (see all 66): About MalaCardsdna ligase iv deficiency xeroderma pigmentosum, group d oculomotor apraxia diffuse large b-cell lymphoma
xeroderma pigmentosum b-cell lymphomas acoustic neuroma artemis deficiency
apraxia severe combined immunodeficiency combined immunodeficiency neuroma
systemic lupus erythematosus microtia lupus erythematosus breast cancer susceptibility
synovial sarcoma acute lymphoblastic leukemia bladder cancer susceptibility chronic lymphocytic leukemia
5 Novoseek disease relationships for XRCC4 gene About this table
Genetic Association Database (GAD): XRCC4
Human Genome Epidemiology (HuGE) Navigator: XRCC4 (60 documents)
Export disorders for XRCC4 gene to outside databases
|
Publications
for XRCC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XRCC4 gene, integrated from 9 sources (see all 224):
(articles sorted by number of sources associating them with XRCC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Monoubiquitination of the nonhomologous end joining protein XRCC4. (PubMed id 16412978)1, 2, 9 Foster R.E.... Frank K.M. (2006)
- Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. (PubMed id 9259561)1, 2, 9 Critchlow S.E.... Jackson S.P. (1997)
- Tetramerization and DNA ligase IV interaction of the DNA double- strand break repair protein XRCC4 are mutually exclusive. (PubMed id 14607114)1, 2, 9 Modesti M.... Kanaar R. (2003)
- Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. (PubMed id 15177042)1, 2, 9 Lee K.J.... Dynan W.S. (2004)
- The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. (PubMed id 15380105)1, 2, 9 Clements P.M....Caldecott K.W. (2004)
- Defining interactions between DNA-PK and ligase IV/XRCC4. (PubMed id 12509254)1, 2, 9 Hsu H.-L.... Chen D.J. (2002)
- Crystal structure of an Xrcc4-DNA ligase IV complex. (PubMed id 11702069)1, 2, 9 Sibanda B.L.... Pellegrini L. (2001)
- The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. (PubMed id 8548796)1, 2, 9 Li Z.... Alt F.W. (1995)
- XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. (PubMed id 16439205)1, 2, 9 Ahnesorg P....Jackson S.P. (2006)
- Regional localization of the XRCC4 human radiation repair gene. (PubMed id 7665175)1, 3, 9 Otevrel T. and Stamato T.D. (1995)
|
External Searches for XRCC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing XRCC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XRCC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XRCC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for XRCC4 gene:
Search GeneIP for patents involving XRCC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for XRCC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for XRCC4 | | OriGene shRNA RFP for XRCC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XRCC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRCC4 | | | OriGene Protein Over-expression Lysate for XRCC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XRCC4 | | OriGene 3'-UTR Clone for XRCC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for XRCC4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XRCC4 | | OriGene Custom Protein Services for XRCC4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XRCC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRCC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRCC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC4 |
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| | | | Search Tocris compounds for XRCC4 |
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 | | | XRCC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC4 |
|  |  |  | | | | ThermoFisher Antibody for XRCC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC4 |
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