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XRCC4 Gene

protein-coding   GIFtS: 66

GC05P082409
X-ray repair complementing defective repair in Chinese hamster cells 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
DNA repair protein XRCC4 2
X-ray repair complementing defective repair in Chinese
hamster cells 4 2
X-ray repair cross complementing protein 4 2
X-ray repair cross-complementing protein 4 3
X-ray repair, complementing defective, repair in Chinese
hamster 2
External Ids
HGNC: 128311
Entrez Gene: 75182
UniProtKB: Q134263
Ensembl: ENSG000001524227
Search outside databases for aliases for XRCC4 gene

Previous GC identifers: GC05P081191 GC05P082600 GC05P082412 GC05P082457

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XRCC4:
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent
protein kinase in the repair of DNA double-strand break by non-homologous end joining and the
completion of V(D)J recombination events. The non-homologous end-joining pathway is required both
for normal development and for suppression of tumors. This gene functionally complements XR-1
Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by
ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative
splicing generates several transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426
Function: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair
and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is
responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding
of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein
kinase complex DNA-PK to these DNA ends

Gene Wiki entry for XRCC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XRCC4 gene  

Entrez Gene cytogenetic band: 5q13-q14   Ensembl cytogenetic band:  5q14.2   HGNC cytogenetic band: 5q14.2

XRCC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P082409:     (about GC identifiers)

Start:
82,409,073 bp from pter
End:
82,685,335 bp from pter
Size:
276,263 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000005.8  NT_006713.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426 (See protein sequence)
Recommended Name: DNA repair protein XRCC4  
Size: 336 amino acids; 38287 Da
Subunit: Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the
LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku
p70/p86 dimer (G22P1/G22P2) and PRKDC. Seems to interact directly with PRKDC but not with the Ku
p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF
Subcellular location: Nucleus
PDB structure from and Proteopedia :
1FU1 (3D)    1IK9 (3D)    
Secondary accessions: Q9BS72 Q9UP94
Alternative splicing: 3 isoforms:  Q13426-1   Q13426-2   Q13426-3   

Post-translational modifications:

  • Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA.
    Phosphorylation by CK2 promotes interaction with APTX1
  • Monoubiquitinated1
  • Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no
    effect on ubiquitination1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_003392.1  NP_071801.1  NP_072044.1  


    ENSEMBL proteins: 
    ENSP00000282268 ENSP00000379344 ENSP00000342011 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (XRCC4)
    Human Recombinant Proteins from Abnova (XRCC4)
                  OriGene Purified Recombinant Human Protein: XRCC4 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793NOT condensed chromosome IDA12589063
    GO:0005634 nucleus NAS16439205
    GO:0005829 cytosol IDA9259561
    GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IDA15194694
    GO:0032807 DNA ligase IV complex IDA9242410
    About this table

    Antibodies for XRCC4: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for XRCC4
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (XRCC4), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (XRCC4)
    Novus Biologicals Antibodies for XRCC4

    Assays for XRCC4: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR009089 XRCC4_N
     IPR014751 XRCC4_C
     IPR010585 XRCC4


       GeneDecks  XRCC4 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q13426

    ProtoNet protein and cluster: Q13426

    UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426
    Similarity: Belongs to the XRCC4 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XRCC4)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003401

                  Applied Biosystems Silencer® siRNAs for XRCC4

                  Sigma-Aldrich siRNA for XRCC4  
                         Sigma-Aldrich shRNA Panels and shRNA for XRCC4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for XRCC4
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_003401
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_003401
                                     untagged cDNA clones in CMV expression vector (see all 4): BC005259 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_022406

    UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426
    Function: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair
    and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is
    responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding
    of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein
    kinase complex DNA-PK to these DNA ends

    Genatlas biochemistry entry for XRCC4:
    repair X-ray defect,complementing defect in CHO cells,4 with CAG repeat,involved in DNA
    double-strand break repair by end joining (non homologous recombination) and V(D)J recombination.
    Also involved in neurogenesis

    14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Xrcc4):

    cellularcraniofacialendocrine/exocrine glandgrowth/sizehematopoietic system
    homeostasis/metabolismimmune systemlethality-prenatal/perinatallife span-post-weaning/agingnervous system
    reproductive systemskeletonskin/coat/nailstumorigenesis

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677NOT DNA binding IDA9259561
    GO:0008022 protein C-terminus binding IPI9259651
    GO:0016874NOT ligase activity IDA9242410
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for XRCC4
     DNA damage NHEJ mechanisms of DSBs repair

       GeneDecks  XRCC4 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for XRCC4):
     hsa03450 Non-homologous end-joining

       GeneDecks  XRCC4 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  XRCC4 


    5/39 Interacting proteins for XRCC4 (Q134261, 2 ENSP000003420113) via UniProtKB, MINT, and/or STRING (see all 39 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E32, ENSP000003691473MINT-51155 MINT-2864227 MINT-51156 STRING (score=.987)
    XRCC5P130102, ENSP000003295283MINT-6175948 MINT-6175964 STRING (score=.994)
    APLFQ8IW192, ENSP000003070043MINT-4790284 STRING (score=.977)
    CSNK2A1PP684002, ENSP000003714003MINT-51176 STRING (score=.941)
    PNKPQ96T601, 2, ENSP000003235113EBI-717592, EBI-1045072 MINT-51171 MINT-51174 MINT-51172 MINT-51173 MINT-51175 EBI-717592, EBI-1045072 MINT-51171 MINT-51174 MINT-51172 MINT-51173 MINT-51175 STRING (score=.968)
    About this table

    5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701 in utero embryonic development IEA--
    GO:0002328 pro-B cell differentiation IEA--
    GO:0006303 double-strand break repair via nonhomologous end joining NAS16439205
    GO:0006974 response to DNA damage stimulus IEA--
    GO:0007417 central nervous system development IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XRCC4
    2 Novoseek chemical compound relationships for XRCC4 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    polynucleotide 57.64 3 18644470 (1), 17353262 (1), 15380105 (1)
    wortmannin 37.36 4 12140331 (4)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XRCC4)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003401

                  Sigma-Aldrich siRNA for XRCC4  
                         Sigma-Aldrich shRNA Panels and shRNA for XRCC4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003401  NM_022406  NM_022550  

    REFSEQ mRNAs for XRCC4 gene (3 alternative transcripts): 

    NM_003401.3   NM_022406.2   NM_022550.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003401  NM_022406  NM_022550  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_003401
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_003401
                                     untagged cDNA clones in CMV expression vector (see all 4): BC005259 

    Additional cDNA sequence: 

    AB017445.1 AK290739.1 BC005259.1 BC010655.1 BC016314.1 BT007216.1 CR599717.1 CR602998.1 
    CR617390.1 U40622.1 

    16 DOTS entries:

    DT.95269018  DT.40220026  DT.312131  DT.92436833  DT.120875805  DT.100819225  DT.120875672  DT.100819221 
    DT.100819224  DT.101986016  DT.100819223  DT.120875671  DT.40109549  DT.92436831  DT.92436832  DT.95269017 

    24/128 AceView cDNA sequences (see all 128 ):

    BM471375 BI760531 AL551668 AL558342 BM564730 CR602998 BX362079 BE781259 
    CR617390 AA314379 CA394395 AI270686 AI289105 R39148 AI795996 BX279574 
    AL543920 BX281210 BG204714 BQ226357 BU171074 BC005259 CR599717 CB144620 

    highest scoring ESTs for XRCC4:

    U40622 AA065267 AA731889 AA909333 AB017445 AI168769 AI270686 AI289105 AI795996 AI922388 

    Unigene Cluster for XRCC4:

    X-ray repair complementing defective repair in Chinese hamster cells 4
    Hs.567359  [show with all ESTs]
    Unigene Representative Sequence: NM_022550


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC4

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                -                       -                     
    SP2:                                -                       -                     
    SP3:                                                                              
    SP4:              -                                                               

    About this scheme

    ECgene alternative splicing isoforms for XRCC4

    3 Ensembl transcripts including schematic representations:
    ENST00000282268  ENST00000396027  ENST00000338635  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XRCC4 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XRCC4

    1 / 2 / 3

    9 probe-sets matching XRCC4 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1360_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U40622 1.00 1.00 1.00 1

    205071_x_at2, 3 U133-A 1 1.00 1.00 -- -- AB017445 0.80 1.00 0.91 1

    210813_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC005259 0.60 1.00 0.82 1

    210812_at2, 3 U133-A 1 1.00 1.00 -- -- BC005259 0.60 1.00 0.82 1

    205072_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_022406 0.60 1.00 0.82 1

    205071_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    210813_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    210812_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    205072_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCTATAATTA

    SOURCE GeneReport for Unigene cluster: Hs.567359

    Expression variation in blood from EXPOLDB for XRCC4

    UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426
    Tissue specificity: Widely expressed

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for XRCC4 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    XRCC41   -- X-ray repair complementing defective repair in Chinese more 87.16(n)
    79.4(a)
    488923  XM_844425.1  XP_849518.1 
    chimpanzee
    (Pan troglodytes)
    XRCC41   -- X-ray repair complementing defective repair in Chinese more 99.4(n)
    98.81(a)
    471491  XM_001148110.1  XP_001148110.1 
    cow
    (Bos taurus)
    XRCC41   -- X-ray repair complementing defective repair in Chinese more 81.29(n)
    72.54(a)
    613590  XM_001250994.1  XP_001250995.1 
    rat
    (Rattus norvegicus)
    Xrcc41   -- X-ray repair complementing defective repair in Chinese more 78.33(n)
    72.76(a)
    309995  NM_001006999.1  NP_001007000.1 
    mouse
    (Mus musculus)
    Xrcc41, 5 135
    X-ray repair complementing defective repair in Chinese more1, 5 81.19(n)1
    76.07(a)1
    1081381  NM_028012.21  NP_082288.11 
     AB0551545  AK0099515  (see all 13)
    About this table        Species with no ortholog for XRCC4

    ENSEMBL Gene Tree for XRCC4
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1850 NCBI SNPs in XRCC4 are shown (see all 1850 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 737)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs47039511,2
    A,C,F,H82685725(+) CTCACA/GTTACT 3 -- ng319Minor allele frequency- G:0.48EU EA WA NS 604
    rs169003571,2
    C,F,H82685080(+) TGCAAA/GGGACA 3 -- ut31 ese312Minor allele frequency- G:0.01NA EU EA WA NS 750
    rs37340911,2
    C,F,H82536490(-) TGAAGC/ACAACC 3 S/A mis1 ese322Minor allele frequency- A:0.06EA MN CSAM NA EU WA NS 3040
    rs283603461,2
    C,F82685394(+) GTAACA/GGGTTT 3 -- ng315Minor allele frequency- G:0.06NS 188
    rs283601351,2
    C,F82527430(+) CACCAT/CTGCAG 3 T/I mis16Minor allele frequency- C:0.02EU NS 288
    rs20359901,2
    C,F82685223(+) ACATAT/CTCTGA 3 -- ut318Minor allele frequency- C:0.23NA NS 328
    rs283603441,2
    F82685253(+) TTAATT/ATGTGT 3 -- ut315Minor allele frequency- A:0.01NS 186
    rs283603421,2
    F82684918(+) CCGTAT/CCTTAC 3 -- ut31 ese35Minor allele frequency- C:0.01NS 186
    rs29744461,2
    H82536470(-) CAGTTT/GGGTTT 3 P/Q mis14Minor allele frequency- G:0.00EU EA WA 418
    --
    rs283603431,2
    F82685227(+) ATTCTG/TAACAT 3 -- ut31 ese35Minor allele frequency- T:0.01NS 186
    About this table

    HapMap Linkage Disequilibrium images for XRCC4 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 194363

    4 Novoseek disease relationships for XRCC4 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune response 25.34 1 12218164 (1)
    cancer 0.00 1 12698192 (1)
    breast cancer 0.00 4 12750264 (2), 9259561 (1), 16485136 (1)
    tumors 0.00 1 16227403 (1)
    About this table

    Human Gene Mutation Database: XRCC4
    Genetic Association Database: XRCC4
    Human Genome Epidemiology Navigator: XRCC4 (32 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/161 PubMed articles for XRCC4 gene (see all 161 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 7518 HGNC: 12831 AceView: XRCC4 Ensembl:ENSG00000152422 euGenes: HUgn7518
    ECgene: XRCC4 H-InvDB: XRCC4
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for XRCC4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/xrcc4/
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XRCC4:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XRCC4-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for XRCC4 Antibodies for XRCC4
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for XRCC4 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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