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XRCC4 Gene

protein-coding GIFtS: 66

GC05P082409

X-ray repair complementing defective repair in Chinese hamster cells 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Descriptions
DNA repair protein XRCC4 ^²
X-ray repair complementing defective repair in Chinese hamster cells 4 ^²
X-ray repair cross complementing protein 4 ^²
X-ray repair cross-complementing protein 4 ^³
X-ray repair, complementing defective, repair in Chinese hamster ^²

External Ids
HGNC: 12831¹
Entrez Gene: 7518²
UniProtKB: Q13426³
Ensembl: ENSG00000152422⁷

Search outside databases for aliases for XRCC4 gene

Previous GC identifers: GC05P081191 GC05P082600 GC05P082412 GC05P082457

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XRCC4:

The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent

protein kinase in the repair of DNA double-strand break by non-homologous end joining and the

completion of V(D)J recombination events. The non-homologous end-joining pathway is required both

for normal development and for suppression of tumors. This gene functionally complements XR-1

Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by

ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative

splicing generates several transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426

Function: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair

and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is

responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding

of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein

kinase complex DNA-PK to these DNA ends

Gene Wiki entry for XRCC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XRCC4 gene

Entrez Gene cytogenetic band: 5q13-q14 Ensembl cytogenetic band: 5q14.2 HGNC cytogenetic band: 5q14.2

XRCC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P082409: (about GC identifiers)

Start:	82,409,073 bp from pter
End:	82,685,335 bp from pter
Size:	276,263 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426 (See protein sequence)

Recommended Name: DNA repair protein XRCC4

Size: 336 amino acids; 38287 Da

Subunit: Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the

LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku

p70/p86 dimer (G22P1/G22P2) and PRKDC. Seems to interact directly with PRKDC but not with the Ku

p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF

Subcellular location: Nucleus

PDB structure from and Proteopedia :

1FU1 (3D)

1IK9 (3D)

Secondary accessions: Q9BS72 Q9UP94

Alternative splicing: 3 isoforms: Q13426-1 Q13426-2 Q13426-3

Post-translational modifications:

Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA.

Phosphorylation by CK2 promotes interaction with APTX¹

Monoubiquitinated¹

Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no

effect on ubiquitination¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_003392.1 NP_071801.1 NP_072044.1

ENSEMBL proteins:

ENSP00000282268 ENSP00000379344 ENSP00000342011

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XRCC4)
	Human Recombinant Proteins from Abnova (XRCC4)

OriGene Purified Recombinant Human Protein: XRCC4

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000793	NOT condensed chromosome	IDA	12589063
GO:0005634	nucleus	NAS	16439205
GO:0005829	cytosol	IDA	9259561
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	IDA	15194694
GO:0032807	DNA ligase IV complex	IDA	9242410

About this table

Antibodies for XRCC4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XRCC4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (XRCC4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XRCC4)
	Novus Biologicals Antibodies for XRCC4

Assays for XRCC4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13426

ProtoNet protein and cluster: Q13426

UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426

Similarity: Belongs to the XRCC4 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRCC4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003401

Applied Biosystems Silencer® siRNAs for XRCC4

Sigma-Aldrich siRNA for XRCC4

Sigma-Aldrich shRNA Panels and shRNA for XRCC4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XRCC4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_003401
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_003401
untagged cDNA clones in CMV expression vector (see all 4): BC005259

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022406

UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426

Function: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair

and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is

responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding

of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein

kinase complex DNA-PK to these DNA ends

Genatlas biochemistry entry for XRCC4:

repair X-ray defect,complementing defect in CHO cells,4 with CAG repeat,involved in DNA

double-strand break repair by end joining (non homologous recombination) and V(D)J recombination.

Also involved in neurogenesis

14 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Xrcc4):

cellular	craniofacial	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system
reproductive system	skeleton	skin/coat/nails	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	NOT DNA binding	IDA	9259561
GO:0008022	protein C-terminus binding	IPI	9259651
GO:0016874	NOT ligase activity	IDA	9242410

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for XRCC4

5/39 Interacting proteins for XRCC4 (Q13426^{1, 2} ENSP00000342011³) via UniProtKB, MINT, and/or STRING (see all 39 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APTX	Q7Z2E3², ENSP00000369147³	MINT-51155 MINT-2864227 MINT-51156 STRING (score=.987)
XRCC5	P13010², ENSP00000329528³	MINT-6175948 MINT-6175964 STRING (score=.994)
APLF	Q8IW19², ENSP00000307004³	MINT-4790284 STRING (score=.977)
CSNK2A1P	P68400², ENSP00000371400³	MINT-51176 STRING (score=.941)
PNKP	Q96T60¹^,², ENSP00000323511³	EBI-717592, EBI-1045072 MINT-51171 MINT-51174 MINT-51172 MINT-51173 MINT-51175 EBI-717592, EBI-1045072 MINT-51171 MINT-51174 MINT-51172 MINT-51173 MINT-51175 STRING (score=.968)

About this table

5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0002328	pro-B cell differentiation	IEA	--
GO:0006303	double-strand break repair via nonhomologous end joining	NAS	16439205
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0007417	central nervous system development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XRCC4
2 Novoseek chemical compound relationships for XRCC4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
polynucleotide	57.64	3	18644470 (1), 17353262 (1), 15380105 (1)
wortmannin	37.36	4	12140331 (4)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRCC4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003401

Sigma-Aldrich siRNA for XRCC4

Sigma-Aldrich shRNA Panels and shRNA for XRCC4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003401 NM_022406 NM_022550

REFSEQ mRNAs for XRCC4 gene (3 alternative transcripts):

NM_003401.3 NM_022406.2 NM_022550.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003401 NM_022406 NM_022550

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_003401
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_003401
                                 untagged cDNA clones in CMV expression vector (see all 4): BC005259

Additional cDNA sequence:

AB017445.1 AK290739.1 BC005259.1 BC010655.1 BC016314.1 BT007216.1 CR599717.1 CR602998.1

CR617390.1 U40622.1

16 DOTS entries:

DT.95269018 DT.40220026 DT.312131 DT.92436833 DT.120875805 DT.100819225 DT.120875672 DT.100819221

DT.100819224 DT.101986016 DT.100819223 DT.120875671 DT.40109549 DT.92436831 DT.92436832 DT.95269017

24/128 AceView cDNA sequences (see all 128 ):

BM471375 BI760531 AL551668 AL558342 BM564730 CR602998 BX362079 BE781259

CR617390 AA314379 CA394395 AI270686 AI289105 R39148 AI795996 BX279574

AL543920 BX281210 BG204714 BQ226357 BU171074 BC005259 CR599717 CB144620

highest scoring ESTs for XRCC4:

U40622 AA065267 AA731889 AA909333 AB017445 AI168769 AI270686 AI289105 AI795996 AI922388

Unigene Cluster for XRCC4:

X-ray repair complementing defective repair in Chinese hamster cells 4

Hs.567359 [show with all ESTs]

Unigene Representative Sequence: NM_022550

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC4

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:											-								-
SP2:											-								-
SP3:
SP4:					-

About this scheme

ECgene alternative splicing isoforms for XRCC4

3 Ensembl transcripts including schematic representations:

ENST00000282268 ENST00000396027 ENST00000338635

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XRCC4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XRCC4

¹ / ² / ³

9 probe-sets matching XRCC4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1360_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U40622	1.00	1.00	1.00	1
205071_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB017445	0.80	1.00	0.91	1
210813_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005259	0.60	1.00	0.82	1
210812_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005259	0.60	1.00	0.82	1
205072_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_022406	0.60	1.00	0.82	1
205071_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210813_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210812_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205072_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTATAATTA

SOURCE GeneReport for Unigene cluster: Hs.567359
Expression variation in blood from EXPOLDB for XRCC4
UniProtKB/Swiss-Prot: XRCC4_HUMAN, Q13426
Tissue specificity: Widely expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XRCC4 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XRCC4¹	--	X-ray repair complementing defective repair in Chinese more	87.16(n) 79.4(a)	488923 XM_844425.1 XP_849518.1
chimpanzee (Pan troglodytes)	XRCC4¹	--	X-ray repair complementing defective repair in Chinese more	99.4(n) 98.81(a)	471491 XM_001148110.1 XP_001148110.1
cow (Bos taurus)	XRCC4¹	--	X-ray repair complementing defective repair in Chinese more	81.29(n) 72.54(a)	613590 XM_001250994.1 XP_001250995.1
rat (Rattus norvegicus)	Xrcc4¹	--	X-ray repair complementing defective repair in Chinese more	78.33(n) 72.76(a)	309995 NM_001006999.1 NP_001007000.1
mouse (Mus musculus)	Xrcc4^{1, 5}	13⁵	X-ray repair complementing defective repair in Chinese more^{1, 5}	81.19(n)¹ 76.07(a)¹	108138¹ NM_028012.2¹ NP_082288.1¹ AB055154⁵ AK009951⁵ (see all 13)

About this table Species with no ortholog for XRCC4

ENSEMBL Gene Tree for XRCC4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1850 NCBI SNPs in XRCC4 are shown (see all 1850 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 737)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4703951^1,2	A,C,F,H	82685725(+)	`CTCACA/GTTACT`	3	--	ng3¹		9	EU EA WA NS	604
	rs16900357^1,2	C,F,H	82685080(+)	`TGCAAA/GGGACA`	3	--	ut3¹ ese³		12	NA EU EA WA NS	750
	rs3734091^1,2	C,F,H	82536490(-)	`TGAAGC/ACAACC`	3	S/A	mis¹ ese³		22	EA MN CSAM NA EU WA NS	3040
	rs28360346^1,2	C,F	82685394(+)	`GTAACA/GGGTTT`	3	--	ng3¹		5	NS	188
	rs28360135^1,2	C,F	82527430(+)	`CACCAT/CTGCAG`	3	T/I	mis¹		6	EU NS	288
	rs2035990^1,2	C,F	82685223(+)	`ACATAT/CTCTGA`	3	--	ut3¹		8	NA NS	328
	rs28360344^1,2	F	82685253(+)	`TTAATT/ATGTGT`	3	--	ut3¹		5	NS	186
	rs28360342^1,2	F	82684918(+)	`CCGTAT/CCTTAC`	3	--	ut3¹ ese³		5	NS	186
	rs2974446^1,2	H	82536470(-)	`CAGTTT/GGGTTT`	3	P/Q	mis¹		4	EU EA WA	418
--	rs28360343^1,2	F	82685227(+)	`ATTCTG/TAACAT`	3	--	ut3¹ ese³		5	NS	186

About this table

HapMap Linkage Disequilibrium images for XRCC4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 194363

4 Novoseek disease relationships for XRCC4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune response	25.34	1	12218164 (1)
cancer	0.00	1	12698192 (1)
breast cancer	0.00	4	12750264 (2), 9259561 (1), 16485136 (1)
tumors	0.00	1	16227403 (1)

About this table

Human Gene Mutation Database: XRCC4
Genetic Association Database: XRCC4
Human Genome Epidemiology Navigator: XRCC4 (32 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/161 PubMed articles for XRCC4 gene (see all 161 ):

Monoubiquitination of the nonhomologous end joining protein XRCC4. (PubMed id 16412978)^{1, 3, 4} Foster R.E....Frank K.M. (2006)
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. (PubMed id 9259561)^{1, 3, 4} Critchlow S.E.... Jackson S.P. (1997)
Tetramerization and DNA ligase IV interaction of the DNA double- strand break repair protein XRCC4 are mutually exclusive. (PubMed id 14607114)^{1, 3, 4} Modesti M.... Kanaar R. (2003)
Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. (PubMed id 15177042)^{1, 3, 4} Lee K.J.... Dynan W.S. (2004)
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. (PubMed id 15380105)^{1, 3, 4} Clements P.M....Caldecott K.W. (2004)
Defining interactions between DNA-PK and ligase IV/XRCC4. (PubMed id 12509254)^{1, 3, 4} Hsu H.-L.... Chen D.J. (2002)
Crystal structure of an Xrcc4-DNA ligase IV complex. (PubMed id 11702069)^{1, 3, 4} Sibanda B.L.... Pellegrini L. (2001)
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. (PubMed id 8548796)^{1, 3, 4} Li Z.... Alt F.W. (1995)
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. (PubMed id 16439205)^{1, 3, 4} Ahnesorg P....Jackson S.P. (2006)
Regional localization of the XRCC4 human radiation repair gene. (PubMed id 7665175)^{1, 2, 3} Otevrel T. and Stamato T.D. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7518	HGNC: 12831	AceView: XRCC4	Ensembl:ENSG00000152422	euGenes: HUgn7518
ECgene: XRCC4	H-InvDB: XRCC4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for XRCC4	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/xrcc4/

Licensable Technologies for XRCC4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XRCC4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XRCC4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XRCC4		Antibodies for XRCC4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XRCC4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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XRCC4 Gene at Home site.
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XRCC4 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for XRCC4

Summaries
for XRCC4

Genomic Location
for XRCC4

Proteins
for XRCC4

Protein Domains/
Families
for XRCC4

Gene Function
for XRCC4

Pathways & Interactions
for XRCC4

Drugs & Compounds
for XRCC4

Transcripts
for XRCC4

Expression
for XRCC4

Orthologs
for XRCC4

Paralogs
for XRCC4

SNPs/Variants
for XRCC4

Disorders & Mutations
for XRCC4

Medical News
for XRCC4

Publications
for XRCC4

Search for XRCC4

Genome Databases showing XRCC4

Other Databases showing XRCC4

Specialized Databases showing XRCC4

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for XRCC4

Services
for XRCC4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XRCC4 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor XRCC4

Summariesfor XRCC4

Genomic Locationfor XRCC4

Proteinsfor XRCC4

Protein Domains/Familiesfor XRCC4

Gene Functionfor XRCC4

Pathways & Interactionsfor XRCC4

Drugs & Compoundsfor XRCC4

Transcriptsfor XRCC4

Expression for XRCC4

Orthologsfor XRCC4

Paralogsfor XRCC4

SNPs/Variantsfor XRCC4

Disorders & Mutationsfor XRCC4

Medical Newsfor XRCC4

Publicationsfor XRCC4

Search for XRCC4

Genome Databases showing XRCC4

Other Databases showing XRCC4

Specialized Databases showing XRCC4

Licensable Technologiesfor XRCC4

Servicesfor XRCC4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XRCC4

Summaries
for XRCC4

Genomic Location
for XRCC4

Proteins
for XRCC4

Protein Domains/
Families
for XRCC4

Gene Function
for XRCC4

Pathways & Interactions
for XRCC4

Drugs & Compounds
for XRCC4

Transcripts
for XRCC4

Expression
for XRCC4

Orthologs
for XRCC4

Paralogs
for XRCC4

SNPs/Variants
for XRCC4

Disorders & Mutations
for XRCC4

Medical News
for XRCC4

Publications
for XRCC4

Licensable Technologies
for XRCC4

Services
for XRCC4