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XRCC3 Gene

protein-coding   GIFtS: 60
GCID: GC14M104163

X-Ray Repair Complementing Defective Repair In Chinese Hamster...

  See XRCC3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells
31 2
X-Ray Repair Cross-Complementing Protein 32 3
CMM62 5
RAD51-like1
DNA Repair Protein XRCC32

External Ids:    HGNC: 128301   Entrez Gene: 75172   Ensembl: ENSG000001262157   OMIM: 6006755   UniProtKB: O435423   

Export aliases for XRCC3 gene to outside databases

Previous GC identifers: GC14M101555 GC14M097979 GC14M102153 GC14M103233 GC14M084342


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XRCC3 Gene:
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination
to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster
irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and
is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients
of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for XRCC3 Gene:
XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) is a protein-coding gene. Diseases associated with XRCC3 include melanoma, cutaneous malignant, 6, and mutagen sensitivity. GO annotations related to this gene include DNA-directed RNA polymerase activity and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair
chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number
under conditions of oxidative stress in the presence of RAD51 and RAD51C

Gene Wiki entry for XRCC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the XRCC3 gene promoter:
         CHOP-10   GR   PPAR-gamma1   p53   GR-beta   PPAR-gamma2   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXRCC3 promoter sequence
   Search Chromatin IP Primers for XRCC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XRCC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.3

XRCC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XRCC3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M104163:  view genomic region     (about GC identifiers)

Start:
104,163,946 bp from pter      End:
104,181,841 bp from pter
Size:
17,896 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542 (See protein sequence)
Recommended Name: DNA repair protein XRCC3  
Size: 346 amino acids; 37850 Da
Subunit: Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3.
Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in
homologous recombination repair
Secondary accessions: O43568 Q9BU18

Explore the universe of human proteins at neXtProt for XRCC3: NX_O43542

Explore proteomics data for XRCC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys172
  • Modification sites at PhosphoSitePlus

  • See XRCC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001093588.1  NP_001093589.1  NP_005423.1  

    ENSEMBL proteins: 
     ENSP00000451362   ENSP00000343392   ENSP00000451974   ENSP00000452598   ENSP00000451361  
     ENSP00000473569   ENSP00000451118   ENSP00000451252   ENSP00000451173   ENSP00000452389  
     ENSP00000450780   ENSP00000450738   ENSP00000412990  

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    Cloud-Clone Corp. Proteins for XRCC3

     
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    antibodies-online peptides for XRCC3

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    antibodies-online kits for XRCC3 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR020588 RecA_ATP-bd
     IPR016467 DNA_recomb/repair_RecA-like
     IPR027417 P-loop_NTPase
     IPR013632 DNA_recomb/repair_Rad51_C

    Graphical View of Domain Structure for InterPro Entry O43542

    ProtoNet protein and cluster: O43542

    UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542
    Similarity: Belongs to the RecA family. RAD51 subfamily


    Find genes that share domains with XRCC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XRCC3_HUMAN, O43542
    Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair
    chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number
    under conditions of oxidative stress in the presence of RAD51 and RAD51C
    Induction: Stress-induced increase in the mitochondrial levels is seen

         Genatlas biochemistry entry for XRCC3:
    repair X-ray defect,complementing defect in CHO cells,3,involved in recombinational repair,interacting with RAD51
    for maintenance of genomic integrity

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000400contributes to four-way junction DNA binding IDA--
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008094DNA-dependent ATPase activity IEA--
         
    Find genes that share ontologies with XRCC3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for XRCC3:
     Synthetic lethal with cisplati  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Xrcc3 (no phenotypes)

    Find genes that share phenotypes with XRCC3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for XRCC3

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XRCC3_HUMAN, O43542: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in
    discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16215984
    GO:0005657replication fork IDA--
    GO:0005737cytoplasm IDA16215984
    GO:0005739mitochondrion IDA--
    GO:0033065Rad51C-XRCC3 complex IDA11751635

    Find genes that share ontologies with XRCC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XRCC3 About    
    See pathways by source

    SuperPathContained pathways About
    1Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacodynamics0.00
    2Homologous recombination
    Homologous recombination0.40
    3Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    Find genes that share SuperPaths with XRCC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for XRCC3
        Fluoropyrimidine Activity
    Integrated Breast Cancer Pathway

    1 PharmGKB Pathway for XRCC3
        Fluoropyrimidine Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for XRCC3):
        Homologous recombination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including XRCC3: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for XRCC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for XRCC3 (O435421, 3 ENSP000003433924) via UniProtKB, MINT, STRING, and/or I2D (see all 230)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCGO152873, ENSP000003679104I2D: score=3 STRING: ENSP00000367910
    RAD51DO757713, ENSP000003780904I2D: score=2 STRING: ENSP00000378090
    RAD51Q066093, ENSP000002678684I2D: score=1 STRING: ENSP00000267868
    ZNHIT3Q156493, ENSP000002254104I2D: score=1 STRING: ENSP00000225410
    RAD51CO435023, ENSP000003367014I2D: score=3 STRING: ENSP00000336701
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IMP--
    GO:0000737DNA catabolic process, endonucleolytic IMP14716019
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair IGI10422536
    GO:0006310DNA recombination TAS9660962

    Find genes that share ontologies with XRCC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XRCC3

    Selected Novoseek inferred chemical compound relationships for XRCC3 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pcb 153 61 9 19069643 (2), 18948301 (1)
    mitomycin c 42.3 3 7603995 (1), 17141189 (1)
    cisplatin 33.2 8 15843498 (2), 16622263 (1), 17141189 (1)
    folate 29 7 19177501 (2), 16997330 (2), 19360465 (1), 15066914 (1) (see all 5)
    benzene 20.3 8 18095557 (3), 17535647 (2), 17605237 (2), 16728435 (1)
    camptothecin 16.3 2 12584174 (2)
    melphalan 13.1 7 11584063 (4), 15843498 (1)
    n acetylcysteine 11.7 1 19069643 (1)
    p003 1.68 2 12007561 (1), 12865926 (1)
    methionine 0 2 17701750 (1), 12223443 (1)

    5 PharmGKB related drug/compound annotations for XRCC3 gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    docetaxelCA  
    fluorouracilCA  
    irinotecanCA  
    leucovorinCA  



    Find genes that share compounds with XRCC3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XRCC3 gene (3 alternative transcripts): 
    NM_001100118.1  NM_001100119.1  NM_005432.3  

    Unigene Cluster for XRCC3:

    X-ray repair complementing defective repair in Chinese hamster cells 3
    Hs.592325  [show with all ESTs]
    Unigene Representative Sequence: BX368160
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000554913(uc001yoa.4) ENST00000352127(uc001ynz.4) ENST00000554811
    ENST00000553264 ENST00000555055(uc001ynx.4 uc001yny.4) ENST00000554974
    ENST00000554774 ENST00000555451 ENST00000555832 ENST00000553807 ENST00000557439
    ENST00000553361 ENST00000556980 ENST00000555964 ENST00000555231 ENST00000556682
    ENST00000553332 ENST00000554170
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    Additional mRNA sequence: BC073820.1 

    1 DOTS entry:

    DT.100773069 

    Selected AceView cDNA sequences (see all 151):

    BM797370 AA595441 AI983015 BX339303 BM557723 AU118580 CR605233 BM915097 
    BM796198 AK022829 BX325623 AU138697 BM803244 CB150648 BX385078 BM127755 
    AF035586 BM128018 BM905634 CR610241 CR613005 BE396817 AU124974 AK126706 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for XRCC3 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -     -     -     -     -                       -                       -                       -     -     -                 -         
    SP2:                                -     -                       -                       -                                                               
    SP3:              -     -           -     -                       -                       -                                                               
    SP4:              -     -     -     -     -                       -                       -                                                               
    SP5:                                -     -                       -                       -                       -     -     -                           


    ECgene alternative splicing isoforms for XRCC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XRCC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTGCAGC
    XRCC3 Expression
    About this image

    XRCC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XRCC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592325
        Pathway & Disease-focused RT2 Profiler PCR Arrays including XRCC3: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XRCC3 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xrcc31 , 5 X-ray repair complementing defective repair in Chinese more1, 5 76.97(n)1
    73.7(a)1
      12 (61.14 cM)5
    743351  NM_028875.21  NP_083151.11 
     1118031925 
    chicken
    (Gallus gallus)
    Aves XRCC31 X-ray repair complementing defective repair in Chinese more 62.34(n)
    62.24(a)
      423485  NM_001006489.1  NP_001006489.1 
    lizard
    (Anolis carolinensis)
    Reptilia XRCC36
    X-ray repair complementing defective repair in Chi...
    52(a)
    1 ↔ 1
    1(6024977-6038048)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia xrcc31 X-ray repair complementing defective repair in Chinese more 58.41(n)
    57.52(a)
      548895  NM_001016141.2  NP_001016141.1 
    zebrafish
    (Danio rerio)
    Actinopterygii xrcc31 X-ray repair complementing defective repair in Chinese more 57.97(n)
    53.33(a)
      541414  NM_001013541.1  NP_001013559.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spn-B1 spindle B 47.06(n)
    39.92(a)
      41746  NM_057392.5  NP_476740.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD576
    Protein that stimulates strand exchange by stabili...
    15(a)
    1 ↔ 1
    IV(455201-456583) YDR004W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XRCC31 XRCC3 43.7(n)
    38.19(a)
      835850  NM_180871.1  NP_851202.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05621001 Os02g0562100 49.44(n)
    39.17(a)
      4329686  NM_001053685.1  NP_001047150.1 


    ENSEMBL Gene Tree for XRCC3 (if available)
    TreeFam Gene Tree for XRCC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for XRCC3 (see all 376)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016475951,2
    --84346512(+) AAAAA-/AAGAGAAG 3 -- int10--------
    rs1862585041,2
    C--84346747(+) CTGCTA/GCCCCA 3 -- int10--------
    rs1392321221,2
    --84346839(+) GCTCTC/TTGCAA 3 -- int10--------
    rs1499582341,2
    --84346880(+) AGCCAA/GTGTCT 3 -- int10--------
    rs32120921,2
    C,F,H--84346937(-) CAGCTC/TAGACA 3 -- int19Minor allele frequency- T:0.03NS EA NA 916
    rs1441897451,2
    --84346944(+) GCTGGA/GTGCCC 3 -- int10--------
    rs8615341,2
    C,F,H--84346994(-) AAGACG/AGCCCT 3 -- int119Minor allele frequency- A:0.24NS NA EA WA CSA 1068
    rs8615331,2
    C,H--84347008(-) TTGCCT/CCTGAG 3 -- int116Minor allele frequency- C:0.00EA NA WA CSA 424
    rs32120901,2
    C,F,O,H--84347156(-) GTGGGG/AAAGAG 3 -- int1 trp315Minor allele frequency- A:0.27NS NA EA WA 1086
    rs1907218721,2
    --84347271(+) GAACAC/TGCTTC 3 -- int10--------

    HapMap Linkage Disequilibrium report for XRCC3 (104163946 - 104181841 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for XRCC3 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749175CNV Deletion23290073
    nsv902308CNV Loss21882294
    nsv902313CNV Loss21882294
    dgv1996n71CNV Loss21882294
    nsv902314CNV Loss21882294
    dgv1995n71CNV Loss21882294
    nsv470673CNV Loss18288195
    nsv902300CNV Loss21882294
    nsv902315CNV Loss21882294
    nsv527425CNV Loss19592680

    Human Gene Mutation Database (HGMD): XRCC3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XRCC3
    DNA2.0 Custom Variant and Variant Library Synthesis for XRCC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600675   
    OMIM disorders: 613972  114480  
    UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast
    neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common
    type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated
    by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different
    families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Melanoma, cutaneous malignant 6 (CMM6) [MIM:613972]: A malignant neoplasm of melanocytes, arising de novo
    or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 11 diseases for XRCC3:    
    About MalaCards
    melanoma, cutaneous malignant, 6    mutagen sensitivity    nonepidermolytic palmoplantar keratoderma    colorectal adenoma
    breast cancer    oral submucous fibrosis    diffuse gastric cancer    breast cancer susceptibility
    squamous cell carcinoma of the head and neck    ovarian cancer    lung cancer

    4 diseases from the University of Copenhagen DISEASES database for XRCC3:
    Xeroderma pigmentosum     Breast cancer     Lung cancer     Urinary bladder cancer

    Find genes that share disorders with XRCC3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for XRCC3 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 53.3 4 16707649 (1), 18630471 (1), 19307510 (1), 17630853 (1)
    chromosomal aberrations 49.7 5 16997330 (2), 17159780 (1), 17923529 (1)
    cancer 48 23 16791138 (4), 9542526 (3), 16137195 (3), 16707649 (3) (see all 12)
    bladder cancer 42.1 14 19815090 (2), 16284380 (2), 12223443 (1), 19429237 (1) (see all 7)
    breast cancer 41.9 26 19426727 (4), 19886181 (3), 12565173 (2), 12023982 (2) (see all 14)
    cancer lung 41.1 12 17034901 (3), 12618330 (2), 17705814 (2), 12917199 (1) (see all 8)
    ataxia telangiectasia 31.1 1 16966185 (1)
    skin cancer 30.3 2 15126335 (1), 16791138 (1)
    genetic susceptibility 23.6 1 18543213 (1)
    adenocarcinoma 21.9 4 16571649 (1), 16540687 (1), 18336773 (1)

    Genetic Association Database (GAD): XRCC3
    Human Genome Epidemiology (HuGE) Navigator: XRCC3 (267 documents)

    Export disorders for XRCC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for XRCC3 gene, integrated from 10 sources (see all 415) (see top 10):
    (articles sorted by number of sources associating them with XRCC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PubMed id 12023982)1, 2, 4, 9 Kuschel B....Dunning A. (Hum. Mol. Genet. 2002)
    2. A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. (PubMed id 11059748)1, 2, 4, 9 Winsey S.L.... Welsh K.I. (Cancer Res. 2000)
    3. XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. (PubMed id 14534887)1, 4, 9 Wang Y....Wu X. (Cancer 2003)
    4. XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study. (PubMed id 19330829)1, 4, 9 Zhou K....Zhou L. (Int. J. Cancer 2009)
    5. Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer. (PubMed id 19426727)1, 4, 9 Krupa R....Blasiak J. (Exp. Mol. Pathol. 2009)
    6. Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. (PubMed id 16492913)1, 4, 9 Smedby K.E....Adami H.O. (amp 2006)
    7. [Relationship between polymorphisms of DNA repair gene XRCC3 and susceptibility to lung cancer]. (PubMed id 18336773)1, 4, 9 Zhang Z.L....Su B. (Zhonghua Jie He He Hu Xi Za Zhi 2007)
    8. [Association between genetic polymorphisms of DNA repair genes XRCC1, XPD, XRCC3 and the capacity of DNA repair induce by benzene]. (PubMed id 18095557)1, 4, 9 Xu J....Wang Q. (Wei Sheng Yan Jiu 2007)
    9. Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to cytostatics. (PubMed id 17159780)1, 4, 9 MusA!k L....PAcc M. (Neuro Endocrinol. Lett. 2006)
    10. XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. (PubMed id 16707649)1, 4, 9 Manuguerra M....Matullo G. (Am. J. Epidemiol. 2006)
    11. XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk. (PubMed id 15767338)1, 4, 9 Stern M.C....Haile R.W. (amp 2005)
    12. Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors: association with late clinical radiosensitivity and cancer incidence. (PubMed id 16137195)1, 4, 9 De Ruyck K....Thierens H. (Radiat. Res. 2005)
    13. Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (PubMed id 15491645)1, 4, 9 Aka P....Kirsch-Volders M. (Mutat. Res. 2004)
    14. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. (PubMed id 9660962)1, 2, 9 Liu N....Thompson L.H. (Mol. Cell 1998)
    15. Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. (PubMed id 9542526)1, 4, 9 Price E.A....Arrand J.E. (Somat. Cell Mol. Genet. 1997)
    16. XRCC1 and XRCC3 DNA repair gene polymorphisms in breast cancer women from the Lodz region of Poland. (PubMed id 19886181)1, 4, 9 Sobczuk A....Smolarz B. (Pol J Pathol 2009)
    17. Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms. (PubMed id 19177501)1, 4, 9 CatalA!n J....Norppa H. (Environ. Mol. Mutagen. 2009)
    18. Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population. (PubMed id 19031937)1, 4, 9 Improta G....Cittadini A. (Anticancer Res. 2008)
    19. XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer. (PubMed id 17986315)1, 4, 9 Jiao L....Li D. (Am. J. Gastroenterol. 2008)
    20. Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. (PubMed id 18582155)1, 4, 9 Burri R.J....Rosenstein B.S. (Radiat. Res. 2008)
    21. [Analysis for the association between genetic polymorphisms of XRCC1, XPD, XRCC3, CCND1 and the latency of the occupational chronic benzene poisoning]. (PubMed id 17605237)1, 4, 9 Xu J.N....Zheng Y.X. (Zhonghua Yu Fang Yi Xue Za Zhi 2007)
    22. [Association between genetic polymorphisms of DNA repair genes XRCC1, XRCC3 and susceptibility to chronic benzene poisoning]. (PubMed id 17535647)1, 4, 9 Huang H.L....Li G.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2007)
    23. Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation. (PubMed id 17131345)1, 4, 9 Vangsted A....Vogel U. (Int. J. Cancer 2007)
    24. Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. (PubMed id 17034901)1, 4, 9 Ryk C....Hou S.M. (Lung Cancer 2006)
    25. DNA repair gene polymorphisms and probability of p53 mutation in bladder cancer. (PubMed id 16652373)1, 4, 9 Stern M.C....Taylor J.A. (Mol. Carcinog. 2006)
    26. DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies. (PubMed id 16791138)1, 4, 9 Han S....Li Y. (Eur. J. Hum. Genet. 2006)
    27. Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples. (PubMed id 16966185)1, 4, 9 Andreassen C.N....Overgaard J. (Int. J. Radiat. Biol. 2006)
    28. Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes. (PubMed id 15990020)1, 4, 9 De Ruyck K....Thierens H. (Int. J. Radiat. Oncol. Biol. Phys. 2005)
    29. Cellular localization of human Rad51C and regulation of ubiquitin- mediated proteolysis of Rad51. (PubMed id 16215984)1, 2, 9 Bennett B.T. and Knight K.L. (J. Cell. Biochem. 2005)
    30. An association of polymorphism of DNA repair genes XRCC1 and XRCC3 with colorectal cancer. (PubMed id 15354414)1, 4, 9 Krupa R. and Blasiak J. (amp 2004)
    31. An assessment of a variant of the DNA repair gene XRCC3 as a possible nevus or melanoma susceptibility genotype. (PubMed id 15009726)1, 4, 9 Bertram C.G....Newton Bishop J.A. (J. Invest. Dermatol. 2004)
    32. Screening of homologous recombination gene polymorphisms in lung cancer patients reveals an association of the NBS1-185Gln variant and p53 gene mutations. (PubMed id 12917199)1, 4, 9 Medina P.P....Sanchez-Cespedes M. (amp 2003)
    33. A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. (PubMed id 19915856)1, 4, 9 Jiang Z....Cai S. (Int J Colorectal Dis 2010)
    34. Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). (PubMed id 19414392)1, 4, 9 Narter K.F....Isbir T. (Anticancer Res. 2009)
    35. Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population? (PubMed id 19815090)1, 4, 9 Gangwar R....Mittal R.D. (Mutat. Res. 2009)
    36. [Association of the Thr241Met polymorphism of DNA repair gene XRCC3 with genetic susceptibility to AFB1-related hepatocellular carcinoma in Guangxi population]. (PubMed id 18543213)1, 4, 9 Long X.D....Wei N.B. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    37. Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to chromium. (PubMed id 18987609)1, 4, 9 Halasova E....Vodicka P. (Neuro Endocrinol. Lett. 2008)
    38. DNA repair gene ERCC2, XPC, XRCC1, XRCC3 polymorphisms and associations with bladder cancer risk in a French cohort. (PubMed id 18630471)1, 4, 9 Fontana L....Bernard-Gallon D.J. (Anticancer Res. 2008)
    39. A combined analysis of XRCC1, XRCC3, GSTM1 and GSTT1 polymorphisms and centromere content of micronuclei in welders. (PubMed id 16551674)1, 4, 9 Iarmarcovai G....Botta A. (Mutagenesis 2006)
    40. Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies. (PubMed id 16997330)1, 4, 9 Skjelbred C.F....Hansteen I.L. (Mutat. Res. 2006)
    41. Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study. (PubMed id 16542436)1, 4, 9 Skjelbred C.F....Kure E.H. (BMC Cancer 2006)
    42. XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk. (PubMed id 17164360)1, 4, 9 Stern M.C....Haile R.W. (amp 2006)
    43. Polymorphisms of the XRCC1, XRCC3, &amp; XPD genes, and colorectal cancer risk: a case-control study in Taiwan. (PubMed id 15679883)1, 4, 9 Yeh C.C....Hsieh L.L. (BMC Cancer 2005)
    44. Risk assessment of welders using analysis of eight metals by ICP-MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays; influence of XRCC1 and XRCC3 polymorphisms. (PubMed id 16234265)1, 4, 9 Iarmarcovai G....Botta A. (Mutagenesis 2005)
    45. Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer. (PubMed id 16425350)1, 4, 9 Duarte M.C....Silva A.E. (World J. Gastroenterol. 2005)
    46. DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. (PubMed id 15386379)1, 4, 9 Benhamou S....Hirvonen A. (Int. J. Cancer 2004)
    47. Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia. (PubMed id 15102670)1, 4, 9 Seedhouse C....Russell N. (Clin. Cancer Res. 2004)
    48. Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. (PubMed id 12565173)1, 4, 9 Smith T.R....Hu J.J. (Cancer Lett. 2003)
    49. DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk. (PubMed id 12223443)1, 4, 9 Stern M.C....Taylor J.A. (amp 2002)
    50. DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients. (PubMed id 19962393)1, 4, 9 Sterpone S....Donato V. (Mutat. Res. 2010)
    51. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. (PubMed id 19286843)1, 4, 9 Akulevich N.M....Yamashita S. (Endocr. Relat. Cancer 2009)
    52. DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk. (PubMed id 19429237)1, 4, 9 Andrew A.S....Karagas M.R. (Toxicol. Lett. 2009)
    53. Genetic polymorphisms and expression of minisatellite mutations in a 3-generation population around the Semipalatinsk nuclear explosion test-site, Kazakhstan. (PubMed id 19656722)1, 4, 9 Bolegenova N.K....Au W.W. (Int J Hyg Environ Health 2009)
    54. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PubMed id 19116388)1, 4, 9 Vineis P....Matullo G. (J. Natl. Cancer Inst. 2009)
    55. Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes. (PubMed id 19027952)1, 4, 9 Fabiani E....Voso M.T. (Leuk. Res. 2009)
    56. Influence of DNA repair gene polymorphisms on the initial repair of MMS-induced DNA damage in human lymphocytes as measured by the alkaline comet assay. (PubMed id 18627000)1, 4, 9 Ryk C....Hou S. (Environ. Mol. Mutagen. 2008)
    57. Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan. (PubMed id 18410587)1, 4, 9 Yen C.Y....Chang H.W. (amp 2008)
    58. Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients. (PubMed id 18977234)1, 4, 9 Synowiec E....Wozniak K. (Mutat. Res. 2008)
    59. International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. (PubMed id 18990748)1, 4, 9 Hung R.J....Brennan P. (amp 2008)
    60. Efficiency of the DNA repair and polymorphisms of the XRCC1, XRCC3 and XRCC4 DNA repair genes in systemic lupus erythematosus. (PubMed id 18852222)1, 4, 9 Bassi C....Donadi E. (Lupus 2008)
    61. The investigation of DNA repair polymorphisms with histopathological characteristics and hormone receptors in a group of Brazilian women with breast cancer. (PubMed id 18752184)1, 4, 9 Dufloth R.M....Zeferino L.C. (Genet. Mol. Res. 2008)
    62. Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy. (PubMed id 18829510)1, 4, 9 Azria D....Rosenstein B.S. (Clin. Cancer Res. 2008)
    63. Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China. (PubMed id 18708406)1, 4, 9 Zhang M....Hsing A.W. (amp 2008)
    64. RAD51 and XRCC3 polymorphism frequency and risk of myelodysplastic syndromes. (PubMed id 18756535)1, 4, 9 Baumann Kreuziger L.M. and Steensma D.P. (Am. J. Hematol. 2008)
    65. DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group. (PubMed id 18033323)1, 4, 9 Bhatla D....Davies S.M. (Leukemia 2008)
    66. The XRCC3 Thr241Met polymorphism and breast cancer risk: a case-control study in a Thai population. (PubMed id 17701750)1, 4, 9 Sangrajrang S....Popanda O. (Biomarkers 2007)
    67. A pharmacogenomic study of docetaxel and gemcitabine for the initial treatment of advanced non-small cell lung cancer. (PubMed id 17410042)1, 4, 9 Petty W.J....Miller A.A. (J Thorac Oncol 2007)
    68. Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain. (PubMed id 17705814)1, 4, 9 LA^pez-Cima M.F....TardA^n A. (BMC Cancer 2007)
    69. Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials. (PubMed id 17197435)1, 4, 9 Kuptsova N....Ambrosone C.B. (Blood 2007)
    70. Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. (PubMed id 17191090)1, 4, 9 Yeh C.C....Hsieh L.L. (J. Biomed. Sci. 2007)
    71. Genetic polymorphisms of the DNA repair gene and risk of nasopharyngeal carcinoma. (PubMed id 17630853)1, 4, 9 Yang Z.H....Zhang L. (DNA Cell Biol. 2007)
    72. The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden. (PubMed id 16571649)1, 4, 9 Ye W....NyrAcn O. (Carcinogenesis 2006)
    73. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)1, 4, 9 Zienolddiny S....Haugen A. (Carcinogenesis 2006)
    74. Pharmacogenetic profiling and clinical outcome of patients with advanced gastric cancer treated with palliative chemotherapy. (PubMed id 16622263)1, 4, 9 Ruzzo A....Magnani M. (J. Clin. Oncol. 2006)
    75. Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency. (PubMed id 17078101)1, 4, 9 Laczmanska I....Sasiadek M.M. (Environ. Mol. Mutagen. 2006)
    76. Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses. (PubMed id 16485136)1, 4, 9 GarcA-a-Closas M....Struewing J.P. (Hum. Genet. 2006)
    77. Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. (PubMed id 16540687)1, 4, 9 Li D....Abbruzzese J.L. (Cancer Res. 2006)
    78. Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin. (PubMed id 16501254)1, 4, 9 Thirumaran R.K....Kumar R. (Carcinogenesis 2006)
    79. Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. (PubMed id 16728435)1, 4, 9 Shen M....Smith M.T. (Carcinogenesis 2006)
    80. Polymorphisms of DNA repair genes are associated with renal cell carcinoma. (PubMed id 16510122)1, 4, 9 Hirata H....Dahiya R. (Biochem. Biophys. Res. Commun. 2006)
    81. Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer. (PubMed id 17116943)1, 4, 9 Bewick M.A....Lafrenie R.M. (J. Clin. Oncol. 2006)
    82. Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. (PubMed id 16638864)1, 4, 9 Damaraju S....Parliament M. (Clin. Cancer Res. 2006)
    83. Genotyping of patients with sporadic and radiation-associated meningiomas. (PubMed id 15824172)1, 4, 9 Sadetzki S....Friedman E. (amp 2005)
    84. The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population. (PubMed id 16271954)1, 4, 9 Jin M.J....Yao K.Y. (Cancer Genet. Cytogenet. 2005)
    85. DNA repair gene polymorphisms in relation to chromosome aberration frequencies in retired radiation workers. (PubMed id 15680411)1, 4, 9 Wilding C.S....Tawn E.J. (Mutat. Res. 2005)
    86. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. (PubMed id 15746160)1, 4, 9 Broberg K....Albin M. (Carcinogenesis 2005)
    87. Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study. (PubMed id 16284380)1, 4, 9 Matullo G....Vineis P. (amp 2005)
    88. Polymorphisms of DNA repair genes and risk of glioma. (PubMed id 15313891)1, 4, 9 Wang L.E....Wei Q. (Cancer Res. 2004)
    89. XRCC3 polymorphisms and risk of lung cancer. (PubMed id 15312685)1, 4, 9 Jacobsen N.R....Vogel U. (Cancer Lett. 2004)
    90. Single nucleotide polymorphisms in breast cancer. (PubMed id 15010895)1, 4, 9 FAPrsti A....Kumar R. (Oncol. Rep. 2004)
    91. Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer. (PubMed id 15199549)1, 4, 9 Harms C....Au W.W. (Environ. Mol. Mutagen. 2004)
    92. Polymorphisms in DNA double-strand break repair genes and skin cancer risk. (PubMed id 15126335)1, 4, 9 Han J....Hunter D.J. (Cancer Res. 2004)
    93. Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk. (PubMed id 15066914)1, 4, 9 Han J....Hunter D.J. (amp 2004)
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    252. Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. (PubMed id 17953974)1, 9 Angelini S....Hrelia P. (Mutat. Res. 2008)
    253. XRCC1 Arg399Gln genetic polymorphism in a Turkish population. (PubMed id 16940014)1, 9 KocabaA9 N.A. and Karahalil B. (Int. J. Toxicol. 2006)
    254. Domain mapping of the Rad51 paralog protein complexes. (PubMed id 14704354)1, 9 Miller K.A....Albala J.S. (Nucleic Acids Res. 2004)
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    256. XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma. (PubMed id 15184273)1, 9 Tranah G.J....Hunter D.J. (amp 2004)
    257. Association between the Thr241Met polymorphism of X-ray repair cross-complementing group 3 gene and glioma risk: evidence from a meta-analysis based on 4,136 cases and 5,233 controls. (PubMed id 23918307)1 Lin J. and Kou Y. (Tumour Biol. 2014)
    258. Association of Thr241Met polymorphism of XRCC3 gene with risk of colorectal cancer in the Polish population. (PubMed id 24166604)1 Mucha B....Majsterek I. (Pol J Pathol 2013)
    259. The genotype distribution of the XRCC1, XRCC3, and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia. (PubMed id 23397959)1 Sorour A....Kassem H. (Genet Test Mol Biomarkers 2013)
    260. XRCC3 Thr241Met polymorphism and risk of acute myeloid leukemia in a Romanian population. (PubMed id 23747401)1 BA8nescu C....Dobreanu M. (Gene 2013)
    261. The influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehyde. (PubMed id 23355119)1 Ladeira C....Brito M. (Environ. Mol. Mutagen. 2013)
    262. XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) single nucleotide polymorphisms in cervical cancer risk. (PubMed id 23539294)1 PAcrez L.O....Golijow C.D. (Pathol. Oncol. Res. 2013)
    263. Significant association between XRCC3 C241T polymorphism and increased risk of hepatocellular carcinoma: a meta-analysis. (PubMed id 23873110)1 Wu D....Jin J. (Tumour Biol. 2013)
    264. Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes. (PubMed id 24053728)1 da Silva A.L....Henriques J.A. (BMC Med. Genet. 2013)
    265. Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus. (PubMed id 23044807)1 Gulnaz A....Ali M. (amp 2013)
    266. Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults. (PubMed id 22427030)1 Kostrzewska-Poczekaj M....Szyfter K. (Eur Arch Otorhinolaryngol 2013)
    267. XRCC3 Thr241Met polymorphism and clinical outcomes of NSCLC patients receiving platinum-based chemotherapy: a systematic review and meta-analysis. (PubMed id 23940523)1 Shen X.Y....Lin Z.F. (PLoS ONE 2013)
    268. Comprehensive assessment of the association between DNA repair gene XRCC3 rs861539 C/T polymorphism and lung cancer risk. (PubMed id 23982880)1 Ding G....Ding Z. (Tumour Biol. 2013)
    269. The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy. (PubMed id 23108668)1 Rodrigue A....Masson J.Y. (J. Cell. Sci. 2013)
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    273. Association between genetic variants of DNA repair genes and coronary artery disease. (PubMed id 23368530)1 Gokkusu C....Umman B. (Genet Test Mol Biomarkers 2013)
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    276. Polymorphisms in DNA repair genes and risk of glioma and meningioma. (PubMed id 23534771)1 Luo K.Q....Peng J.C. (Asian Pac. J. Cancer Prev. 2013)
    277. ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. (PubMed id 23438602)1 Somyajit K....Nagaraju G. (Mol. Cell. Biol. 2013)
    278. No significant association between the XRCC3 Thr241Met polymorphism and lung cancer risk: a meta-analysis. (PubMed id 23300009)1 Xu Y.H....Lu S. (Tumour Biol. 2013)
    279. Association between the XRCC3 T241M polymorphism and risk of cancer: evidence from 157 case-control studies. (PubMed id 23562721)1 He X.F....Xie D.L. (Gene 2013)
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    283. Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients. (PubMed id 22775506)1 Dos Reis M.B....de Syllos CA^lus I.M. (amp 2013)
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    286. Single nucleotide polymorphism (SNP) Thr241Met in the XRCC3 gene and breast cancer risk in Polish women. (PubMed id 22864780)1 Romanowicz-Makowska H....Smolarz B. (Pol J Pathol 2012)
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    290. An interethnic variability and a functional prediction of DNA repair gene polymorphisms: the example of XRCC3 (p.Thr241&gt;Met) and XPD (p.Lys751&gt;Gln) in a healthy Tunisian population. (PubMed id 22740138)1 Ben Salah G....Fakhfakh F. (Mol. Biol. Rep. 2012)
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    298. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
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    312. Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. (PubMed id 21951951)1 Diamond H.R....Abdelhay E. (amp 2011)
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    314. Association of XRCC3 C722T and RAD51 G135C polymorphisms with head and neck cancer susceptibility in a Polish population. (PubMed id 21397596)1 Wang F....Feng X.L. (Exp. Mol. Pathol. 2011)
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    319. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
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    327. Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of articledeveloping erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery. (PubMed id 21749698)1 Falvo E....PinnarA^ P. (BMC Cancer 2011)
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    340. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. (PubMed id 18212739)1 Wilson J.B....Jones N.J. (Oncogene 2008)
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    366. RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis. (PubMed id 17268176)9 Renglin Lindh A....Helleday T. (Cytogenet. Genome Res. 2007)
    367. Interplay between human DNA repair proteins at a unique double-strand break in vivo. (PubMed id 16395335)9 Rodrigue A....Masson J.Y. (EMBO J. 2006)
    368. DNA repair gene polymorphisms, pre-natal factors and the frequency of somatic mutations in the glycophorin-A gene among healthy newborns. (PubMed id 14698416)9 Relton C.L....Burn J. (Mutat. Res. 2004)
    369. Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3. (PubMed id 12584174)9 Hinz J.M....Meuth M. (Carcinogenesis 2003)
    370. Homologous recombinational repair vis-A -vis chlorambucil resistance in chronic lymphocytic leukemia. (PubMed id 12007561)9 Bello V.E....Panasci L.C. (Biochem. Pharmacol. 2002)
    371. In vitro evidence for homologous recombinational repair in resistance to melphalan. (PubMed id 11584063)9 Wang Z.M....Panasci L.C. (J. Natl. Cancer Inst. 2001)
    372. Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. (PubMed id 11025669)9 Griffin C.S....Thacker J. (Nat. Cell Biol. 2000)
    373. Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants. (PubMed id 11126366)9 Asaad N.A....Iliakis G. (Oncogene 2000)
    374. Micronuclei in humans induced by exposure to low level of ionizing radiation: influence of polymorphisms in DNA repair genes. (PubMed id 15680408)9 Angelini S....Hrelia P. (Mutat. Res. 2005)
    375. Genetic interactions between RAD51 and its paralogues for centrosome fragmentation and ploidy control, independently of the sensitivity to genotoxic stresses. (PubMed id 15782136)9 Daboussi F....Lopez B.S. (Oncogene 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7517 HGNC: 12830 AceView: XRCC3 Ensembl:ENSG00000126215 euGenes: HUgn7517
    ECgene: XRCC3 Kegg: 7517 H-InvDB: XRCC3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for XRCC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XRCC3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/xrcc3/

    (Patent information from GeneIP,
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    Patent Information for XRCC3 gene:
    Search GeneIP for patents involving XRCC3

    GeneCards and IP:
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