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Aliases for XRCC3 Gene

Aliases for XRCC3 Gene

  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 3 2 3 5
  • X-Ray Repair Cross-Complementing Protein 3 3 4
  • RAD51-Like 2
  • CMM6 3

External Ids for XRCC3 Gene

Previous GeneCards Identifiers for XRCC3 Gene

  • GC14M101555
  • GC14M097979
  • GC14M102153
  • GC14M103233
  • GC14M104163
  • GC14M084342

Summaries for XRCC3 Gene

Entrez Gene Summary for XRCC3 Gene

  • This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for XRCC3 Gene

XRCC3 (X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 3) is a Protein Coding gene. Diseases associated with XRCC3 include melanoma, cutaneous malignant, 6 and breast cancer. Among its related pathways are Homologous recombination and Pyrimidine metabolism (REACTOME). GO annotations related to this gene include DNA-dependent ATPase activity and crossover junction endodeoxyribonuclease activity.

UniProtKB/Swiss-Prot for XRCC3 Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Gene Wiki entry for XRCC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC3 Gene

Genomics for XRCC3 Gene

Regulatory Elements for XRCC3 Gene

Enhancers for XRCC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around XRCC3 on UCSC Golden Path with GeneCards custom track

Promoters for XRCC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around XRCC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for XRCC3 Gene

Chromosome:
14
Start:
103,697,608 bp from pter
End:
103,715,504 bp from pter
Size:
17,897 bases
Orientation:
Minus strand

Genomic View for XRCC3 Gene

Genes around XRCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XRCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XRCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRCC3 Gene

Proteins for XRCC3 Gene

  • Protein details for XRCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43542-XRCC3_HUMAN
    Recommended name:
    DNA repair protein XRCC3
    Protein Accession:
    O43542
    Secondary Accessions:
    • O43568
    • Q9BU18

    Protein attributes for XRCC3 Gene

    Size:
    346 amino acids
    Molecular mass:
    37850 Da
    Quaternary structure:
    • Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.

neXtProt entry for XRCC3 Gene

Proteomics data for XRCC3 Gene at MOPED

Post-translational modifications for XRCC3 Gene

  • Ubiquitination at Lys 172
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for XRCC3 Gene

Domains & Families for XRCC3 Gene

Protein Domains for XRCC3 Gene

Graphical View of Domain Structure for InterPro Entry

O43542

UniProtKB/Swiss-Prot:

XRCC3_HUMAN :
  • Belongs to the RecA family. RAD51 subfamily.
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with XRCC3: view

No data available for Gene Families for XRCC3 Gene

Function for XRCC3 Gene

Molecular function for XRCC3 Gene

GENATLAS Biochemistry:
repair X-ray defect,complementing defect in CHO cells,3,involved in recombinational repair,interacting with RAD51 for maintenance of genomic integrity
UniProtKB/Swiss-Prot Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
UniProtKB/Swiss-Prot Induction:
Stress-induced increase in the mitochondrial levels is seen.

Gene Ontology (GO) - Molecular Function for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IBA --
GO:0008094 DNA-dependent ATPase activity IEA,IBA --
GO:0008821 contributes_to crossover junction endodeoxyribonuclease activity IMP 14716019
genes like me logo Genes that share ontologies with XRCC3: view
genes like me logo Genes that share phenotypes with XRCC3: view

Animal Models for XRCC3 Gene

MGI Knock Outs for XRCC3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XRCC3 Gene

Localization for XRCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRCC3 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XRCC3 Gene COMPARTMENTS Subcellular localization image for XRCC3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005657 replication fork IDA 20207730
GO:0005737 cytoplasm IDA 16215984
GO:0033065 Rad51C-XRCC3 complex IDA 11751635
genes like me logo Genes that share ontologies with XRCC3: view

Pathways & Interactions for XRCC3 Gene

genes like me logo Genes that share pathways with XRCC3: view

Gene Ontology (GO) - Biological Process for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000707 meiotic DNA recombinase assembly IBA --
GO:0000732 strand displacement TAS --
GO:0007131 reciprocal meiotic recombination IBA --
GO:0010033 response to organic substance IEA --
GO:0010212 response to ionizing radiation IBA --
genes like me logo Genes that share ontologies with XRCC3: view

No data available for SIGNOR curated interactions for XRCC3 Gene

Drugs & Compounds for XRCC3 Gene

(10) Drugs for XRCC3 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1697
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1055
leucovorin Approved Pharma 1029

(4) Additional Compounds for XRCC3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XRCC3: view

Transcripts for XRCC3 Gene

Unigene Clusters for XRCC3 Gene

X-ray repair complementing defective repair in Chinese hamster cells 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XRCC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - -
SP11: - - - -
SP12: - - - -
SP13:

Relevant External Links for XRCC3 Gene

GeneLoc Exon Structure for
XRCC3
ECgene alternative splicing isoforms for
XRCC3

Expression for XRCC3 Gene

mRNA expression in normal human tissues for XRCC3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XRCC3 Gene



SOURCE GeneReport for Unigene cluster for XRCC3 Gene Hs.592325

genes like me logo Genes that share expression patterns with XRCC3: view

Protein tissue co-expression partners for XRCC3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for XRCC3 Gene

Orthologs for XRCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XRCC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XRCC3 35
  • 79.09 (n)
  • 76.63 (a)
XRCC3 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XRCC3 35
  • 82.61 (n)
  • 76.23 (a)
XRCC3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xrcc3 35
  • 76.97 (n)
  • 73.7 (a)
Xrcc3 16
Xrcc3 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XRCC3 35
  • 99.33 (n)
  • 99.71 (a)
XRCC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102551085 35
  • 77.52 (n)
  • 74.78 (a)
oppossum
(Monodelphis domestica)
Mammalia XRCC3 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XRCC3 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves XRCC3 35
  • 62.34 (n)
  • 62.24 (a)
XRCC3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XRCC3 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xrcc3 35
  • 58.41 (n)
  • 57.52 (a)
zebrafish
(Danio rerio)
Actinopterygii xrcc3 35
  • 57.97 (n)
  • 53.33 (a)
xrcc3 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013180 35
  • 45.18 (n)
  • 36.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta spn-B 35
  • 47.06 (n)
  • 39.92 (a)
spn-B 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD57 36
  • 15 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons XRCC3 35
  • 43.7 (n)
  • 38.19 (a)
rice
(Oryza sativa)
Liliopsida Os02g0562100 35
  • 49.44 (n)
  • 39.17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01771 35
  • 48.35 (n)
  • 38.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp57 35
  • 38.51 (n)
  • 29.19 (a)
Species with no ortholog for XRCC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRCC3 Gene

ENSEMBL:
Gene Tree for XRCC3 (if available)
TreeFam:
Gene Tree for XRCC3 (if available)

Paralogs for XRCC3 Gene

No data available for Paralogs for XRCC3 Gene

Variants for XRCC3 Gene

Sequence variations from dbSNP and Humsavar for XRCC3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_013006 -
rs3212057 - 103,707,128(-) GCTCC(A/G)CGGTG reference, missense
VAR_029295 -
VAR_029296 -
rs709401 -- 103,705,608(-) GCCAC(C/T)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XRCC3 Gene

Variant ID Type Subtype PubMed ID
nsv902300 CNV Loss 21882294
nsv902308 CNV Loss 21882294
dgv1995n71 CNV Loss 21882294
dgv658e1 CNV Complex 17122850
nsv527425 CNV Loss 19592680
nsv470673 CNV Loss 18288195
nsv902313 CNV Loss 21882294
nsv902314 CNV Loss 21882294
nsv902315 CNV Loss 21882294
esv2749175 CNV Deletion 23290073
dgv1996n71 CNV Loss 21882294
nsv9171 CNV Gain 18304495
nsv827071 CNV Gain 20364138

Variation tolerance for XRCC3 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XRCC3 Gene

HapMap Linkage Disequilibrium report
XRCC3
Human Gene Mutation Database (HGMD)
XRCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC3 Gene

Disorders for XRCC3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for XRCC3 Gene - From: OMIM, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma, cutaneous malignant, 6
  • melanoma, cutaneous malignant 6
breast cancer
  • breast cancer, invasive ductal
mutagen sensitivity
larynx cancer
  • laryngeal neoplasms
xeroderma pigmentosum, variant type
  • de sanctis-cacchione syndrome
- elite association - COSMIC cancer census association via MalaCards
Search XRCC3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

XRCC3_HUMAN
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:12023982}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Melanoma, cutaneous malignant 6 (CMM6) [MIM:613972]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. {ECO:0000269 PubMed:11059748}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for XRCC3

Genetic Association Database (GAD)
XRCC3
Human Genome Epidemiology (HuGE) Navigator
XRCC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XRCC3
genes like me logo Genes that share disorders with XRCC3: view

No data available for Genatlas for XRCC3 Gene

Publications for XRCC3 Gene

  1. Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PMID: 12023982) Kuschel B. … Dunning A. (Hum. Mol. Genet. 2002) 3 4 23 48 67
  2. Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. (PMID: 7603995) Tebbs R.S. … Thompson L.H. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 23
  3. A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. (PMID: 19915856) Jiang Z. … Cai S. (Int J Colorectal Dis 2010) 3 23
  4. Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51. (PMID: 20004634) Silva S.N. … Gaspar J.F. (Cancer Epidemiol 2010) 3 23
  5. Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms. (PMID: 19177501) CatalA!n J. … Norppa H. (Environ. Mol. Mutagen. 2009) 3 23

Products for XRCC3 Gene

Sources for XRCC3 Gene

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