Aliases for XRCC3 Gene
Aliases for XRCC3 Gene
External Ids for XRCC3 Gene
- HGNC: 12830
- Entrez Gene: 7517
- Ensembl: ENSG00000126215
- OMIM: 600675
- UniProtKB: O43542
Previous GeneCards Identifiers for XRCC3 Gene
- GC14M101555
- GC14M097979
- GC14M102153
- GC14M103233
- GC14M104163
- GC14M084342
Summaries for XRCC3 Gene
-
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for XRCC3 Gene
XRCC3 (X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 3) is a Protein Coding gene. Diseases associated with XRCC3 include Melanoma, Cutaneous Malignant, 6 and Breast Cancer. Among its related pathways are Resolution of D-Loop Structures and DNA Double-Strand Break Repair. GO annotations related to this gene include DNA-dependent ATPase activity and crossover junction endodeoxyribonuclease activity.
UniProtKB/Swiss-Prot for XRCC3 Gene
-
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC3 Gene
Genomics for XRCC3 Gene
Regulatory Elements for XRCC3 Gene
Enhancers for XRCC3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around XRCC3 on UCSC Golden Path with GeneCards custom track
Promoters for XRCC3 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around XRCC3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the XRCC3 gene promoter:
Regulatory Element Products
Genomic Location for XRCC3 Gene
- Chromosome:
- 14
- Start:
- 103,697,608 bp from pter
- End:
- 103,715,504 bp from pter
- Size:
- 17,897 bases
- Orientation:
- Minus strand
Genomic View for XRCC3 Gene
Genes around XRCC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.3 by Entrez Gene
- 14q32.3 by HGNC
XRCC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XRCC3 Gene
Proteins for XRCC3 Gene
-
Protein details for XRCC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43542-XRCC3_HUMAN
- Recommended name:
- DNA repair protein XRCC3
- Protein Accession:
- O43542
- O43568
- Q9BU18
Protein attributes for XRCC3 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 37850 Da
- Quaternary structure:
-
- Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.
Protein Expression for XRCC3 Gene
Post-translational modifications for XRCC3 Gene
Other Protein References for XRCC3 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for XRCC3
- Novus Biologicals Antibodies for XRCC3
- Invitrogen Antibodies for XRCC3
- antibodies-online Antibodies for XRCC3: See all 109
- GeneTex XRCC3 antibody for XRCC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for XRCC3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for XRCC3
- Origene Custom Protein Services for XRCC3
- antibodies-online Proteins for XRCC3: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for XRCC3
Assay Products
- antibodies-online Kits for XRCC3: See all 1
No data available for DME Specific Peptides for XRCC3 Gene
Domains & Families for XRCC3 Gene
Protein Domains for XRCC3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for XRCC3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43542- Family:
-
- Belongs to the RecA family. RAD51 subfamily.
No data available for Gene Families for XRCC3 Gene
Function for XRCC3 Gene
Molecular function for XRCC3 Gene
- GENATLAS Biochemistry:
- repair X-ray defect,complementing defect in CHO cells,3,involved in recombinational repair,interacting with RAD51 for maintenance of genomic integrity
- UniProtKB/Swiss-Prot Function:
- Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
- UniProtKB/Swiss-Prot Induction:
- Stress-induced increase in the mitochondrial levels is seen.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003697 | single-stranded DNA binding | IBA | -- |
| GO:0008094 | DNA-dependent ATPase activity | IEA,IBA | -- |
| GO:0008821 | contributes_to crossover junction endodeoxyribonuclease activity | IMP | 14716019 |
Phenotypes for XRCC3 Gene
- MGI mutant phenotypes for XRCC3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for XRCC3:
-
- Increased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance
- Increased viability with MLN4924 (a NAE inhibitor)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Synthetic lethal with cisplatin
Animal Models for XRCC3 Gene
- MGI Knock Outs for XRCC3:
-
- Xrcc3 tm1b(KOMP)Mbp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for XRCC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC3 gene
- Search ViGene Biosciences for XRCC3
CRISPR Products
-
OriGene CRISPR knockouts for XRCC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for XRCC3
- GenScript: Design CRISPR guide RNA sequences for XRCC3
miRNA for XRCC3 Gene
- miRTarBase miRNAs that target XRCC3
-
- hsa-mir-6746-3p (MIRT114265)
- hsa-mir-6736-5p (MIRT482697)
- hsa-mir-4651 (MIRT482698)
- hsa-mir-4701-3p (MIRT482699)
- hsa-mir-1262 (MIRT482700)
- hsa-mir-6858-5p (MIRT482701)
- hsa-mir-4689 (MIRT482702)
- hsa-mir-6748-5p (MIRT482703)
- hsa-mir-6769b-5p (MIRT482704)
- hsa-mir-6769a-5p (MIRT482705)
- hsa-mir-4710 (MIRT482706)
- hsa-mir-6134 (MIRT482707)
- hsa-mir-765 (MIRT482708)
- hsa-mir-4784 (MIRT482709)
- hsa-mir-3150b-3p (MIRT482710)
- hsa-mir-4257 (MIRT482711)
- hsa-mir-1912 (MIRT482712)
- hsa-mir-1295b-5p (MIRT482713)
- hsa-mir-1277-5p (MIRT503290)
- hsa-mir-190a-3p (MIRT503291)
- hsa-mir-5011-5p (MIRT503292)
- hsa-mir-5580-3p (MIRT503293)
- hsa-mir-574-5p (MIRT508304)
- hsa-mir-6867-5p (MIRT508305)
- hsa-mir-223-5p (MIRT508306)
- hsa-mir-511-3p (MIRT508307)
- hsa-mir-548t-3p (MIRT514558)
- hsa-mir-548ap-3p (MIRT514559)
- hsa-mir-548aa (MIRT514560)
- hsa-mir-548z (MIRT514561)
- hsa-mir-548h-3p (MIRT514562)
- hsa-mir-548d-3p (MIRT514563)
- hsa-mir-548bb-3p (MIRT514564)
- hsa-mir-548ac (MIRT514565)
- hsa-mir-6075 (MIRT609254)
- hsa-mir-4673 (MIRT609255)
- hsa-mir-4645-5p (MIRT609256)
- hsa-mir-4692 (MIRT609257)
- hsa-mir-4514 (MIRT609258)
- hsa-mir-6511a-5p (MIRT609259)
- hsa-mir-1910-3p (MIRT609260)
- hsa-mir-4484 (MIRT613419)
- hsa-mir-6768-3p (MIRT613420)
- hsa-mir-548an (MIRT613421)
- hsa-mir-410-3p (MIRT707104)
miRNA Products
- Search ViGene Biosciences for XRCC3
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for XRCC3
- Browse OriGene Inhibitory RNA Products For XRCC3
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC3 gene
Clone Products
- OriGene clones in human for XRCC3
- OriGene ORF clones in human,mouse for XRCC3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for XRCC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XRCC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XRCC3 Gene
Localization for XRCC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for XRCC3 Gene
- Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005657 | replication fork | IDA | 20207730 |
| GO:0005737 | cytoplasm | IDA | 16215984 |
| GO:0033065 | Rad51C-XRCC3 complex | IDA | 11751635 |
Pathways & Interactions for XRCC3 Gene
More details on SuperPathways for XRCC3| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Double-Strand Break Repair |
.53
|
|
| 2 | Resolution of D-Loop Structures | ||
| 3 | Pyrimidine metabolism (REACTOME) | ||
| 4 | Homologous DNA Pairing and Strand Exchange | ||
| 5 | Homologous recombination |
Pathways by source for XRCC3 Gene
2 BioSystems pathways for XRCC3 Gene
1 PharmGKB pathway for XRCC3 Gene
1 KEGG pathway for XRCC3 Gene
Interacting Proteins for XRCC3 Gene
Selected Interacting proteins:
ENSP00000343392
O43542-XRCC3_HUMAN
for XRCC3 Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000707 | meiotic DNA recombinase assembly | IBA | -- |
| GO:0000732 | strand displacement | TAS | -- |
| GO:0007131 | reciprocal meiotic recombination | IBA | -- |
| GO:0010033 | response to organic substance | IEA | -- |
| GO:0010212 | response to ionizing radiation | IBA | -- |
No data available for SIGNOR curated interactions for XRCC3 Gene
Drugs & Compounds for XRCC3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 1697 | ||
| Irinotecan | Approved, Investigational | Pharma | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1055 | ||
| leucovorin | Approved | Pharma | 1029 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for XRCC3 Gene
mRNA/cDNA for XRCC3 Gene
- (5) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (151) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XRCC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XRCC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for XRCC3
- GenScript: Design CRISPR guide RNA sequences for XRCC3
miRNA Products
- Search ViGene Biosciences for XRCC3
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for XRCC3
- Browse OriGene Inhibitory RNA Products For XRCC3
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC3 gene
Clone Products
- OriGene clones in human for XRCC3
- OriGene ORF clones in human,mouse for XRCC3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
Expression for XRCC3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XRCC3 Gene
SOURCE GeneReport for Unigene cluster for XRCC3 Gene Hs.592325
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for XRCC3
-
OriGene qPCR primer pairs and template standards for XRCC3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for XRCC3 Gene
Orthologs for XRCC3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | XRCC3 35 |
|
||
| XRCC3 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | XRCC3 35 |
|
||
| XRCC3 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Xrcc3 35 |
|
||
| Xrcc3 16 |
|
||||
| Xrcc3 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | XRCC3 35 |
|
||
| XRCC3 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | LOC102551085 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | XRCC3 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | XRCC3 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | XRCC3 35 |
|
||
| XRCC3 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | XRCC3 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | xrcc3 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | xrcc3 35 |
|
||
| xrcc3 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP013180 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | spn-B 35 |
|
||
| spn-B 36 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAD57 36 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | XRCC3 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0562100 35 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01771 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rhp57 35 |
|
- Species with no ortholog for XRCC3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for XRCC3 Gene
No data available for Paralogs for XRCC3 Gene
Variants for XRCC3 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_013006 | - | ||||
| rs3212057 | - | 103,707,128(-) | GCTCC(A/G)CGGTG | reference, missense | |
| VAR_029295 | - | ||||
| VAR_029296 | - | ||||
| rs709401 | -- | 103,705,608(-) | GCCAC(C/T)GTGAC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv902300 | CNV | Loss | 21882294 |
| nsv902308 | CNV | Loss | 21882294 |
| dgv1995n71 | CNV | Loss | 21882294 |
| dgv658e1 | CNV | Complex | 17122850 |
| nsv527425 | CNV | Loss | 19592680 |
| nsv470673 | CNV | Loss | 18288195 |
| nsv902313 | CNV | Loss | 21882294 |
| nsv902314 | CNV | Loss | 21882294 |
| nsv902315 | CNV | Loss | 21882294 |
| esv2749175 | CNV | Deletion | 23290073 |
| dgv1996n71 | CNV | Loss | 21882294 |
| nsv9171 | CNV | Gain | 18304495 |
| nsv827071 | CNV | Gain | 20364138 |
Residual Variation Intolerance Score:
75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.18;
75.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for XRCC3 Gene
- Human Gene Mutation Database (HGMD)
- XRCC3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC3 Gene
Disorders for XRCC3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma, cutaneous malignant, 6 |
|
|
| breast cancer |
|
|
| mutagen sensitivity |
|
|
| larynx cancer |
|
|
| xeroderma pigmentosum, variant type |
|
Search XRCC3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
XRCC3_HUMAN- Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:12023982}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Melanoma, cutaneous malignant 6 (CMM6) [MIM:613972]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. {ECO:0000269 PubMed:11059748}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Relevant External Links for XRCC3
No data available for Genatlas for XRCC3 Gene
Publications for XRCC3 Gene
- Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PMID: 12023982) Kuschel B. … Dunning A. (Hum. Mol. Genet. 2002) 3 4 23 48 67
- Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. (PMID: 7603995) Tebbs R.S. … Thompson L.H. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 23
- A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. (PMID: 19915856) Jiang Z. … Cai S. (Int J Colorectal Dis 2010) 3 23
- Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51. (PMID: 20004634) Silva S.N. … Gaspar J.F. (Cancer Epidemiol 2010) 3 23
- Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms. (PMID: 19177501) CatalA!n J. … Norppa H. (Environ. Mol. Mutagen. 2009) 3 23
Products for XRCC3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for XRCC3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for XRCC3
- Origene Custom Protein Services for XRCC3
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for XRCC3
- Browse OriGene Inhibitory RNA Products For XRCC3
- OriGene qPCR primer pairs for XRCC3
- OriGene qPCR primer pairs and template standards for XRCC3
- OriGene CRISPR knockouts for XRCC3
- OriGene clones in human for XRCC3
- OriGene ORF clones in human,mouse for XRCC3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for XRCC3
- GenScript Custom Assay Services for XRCC3
- GenScript Custom overexpressing Cell Line Services for XRCC3
- GenScript: Design CRISPR guide RNA sequences for XRCC3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for XRCC3
- Novus Biologicals Antibodies for XRCC3
- Novus Biologicals proteins and lysates for XRCC3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for XRCC3: See all 109
- antibodies-online Kits for XRCC3: See all 1
- antibodies-online Proteins for XRCC3: See all 12
- Search antibodies-online for peptides
- GeneTex XRCC3 antibody for XRCC3
- Search GeneTex for Proteins for XRCC3
- ViGene Biosciences adenoviral particle packaged cDNA for XRCC3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XRCC3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XRCC3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XRCC3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XRCC3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XRCC3 gene
- Search ViGene Biosciences for XRCC3
- Search ViGene Biosciences for XRCC3
- Santa Cruz Biotechnology (SCBT) Antibodies for XRCC3
- Search Santa Cruz Biotechnology (SCBT) for XRCC3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for XRCC3
Sources for XRCC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon