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XRCC3 Gene

protein-coding GIFtS: 60
GCID: GC14M104163

X-Ray Repair Complementing Defective Repair In Chinese Hamster...

See XRCC3-related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 3¹ ²
X-Ray Repair Cross-Complementing Protein 3² ³
CMM6² ⁵
RAD51-like¹
DNA Repair Protein XRCC3²

External Ids:	HGNC: 12830¹	Entrez Gene: 7517²	Ensembl: ENSG00000126215⁷	OMIM: 600675⁵	UniProtKB: O43542³

Export aliases for XRCC3 gene to outside databases

Previous GC identifers: GC14M101555 GC14M097979 GC14M102153 GC14M103233 GC14M084342

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XRCC3 Gene:

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination

to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster

irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and

is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients

of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been

identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for XRCC3 Gene:

XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) is a protein-coding gene. Diseases associated with XRCC3 include melanoma, cutaneous malignant, 6, and breast cancer. GO annotations related to this gene include DNA-directed RNA polymerase activity and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542

Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair

chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number

under conditions of oxidative stress in the presence of RAD51 and RAD51C

Gene Wiki entry for XRCC3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000014.8 NT_026437.13 NC_018925.2

Regulatory elements:

Regulatory transcription factor binding sites in the XRCC3 gene promoter:
CHOP-10 GR PPAR-gamma1 p53 GR-beta PPAR-gamma2 GR-alpha C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XRCC3 promoter sequence

Search Chromatin IP Primers for XRCC3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XRCC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.3

XRCC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XRCC3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M104163: view genomic region (about GC identifiers)

Start:	104,163,946 bp from pter	End:	104,181,841 bp from pter
Size:	17,896 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542 (See protein sequence)

Recommended Name: DNA repair protein XRCC3

Size: 346 amino acids; 37850 Da

Subunit: Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3.

Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in

homologous recombination repair

Secondary accessions: O43568 Q9BU18

Explore the universe of human proteins at neXtProt for XRCC3: NX_O43542

Explore proteomics data for XRCC3 at MOPED

Post-translational modifications:

Ubiquitination² at Lys172

Modification sites at PhosphoSitePlus

See XRCC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001093588.1 NP_001093589.1 NP_005423.1

ENSEMBL proteins:

ENSP00000451362 ENSP00000343392 ENSP00000451974 ENSP00000452598 ENSP00000451361

ENSP00000473569 ENSP00000451118 ENSP00000451252 ENSP00000451173 ENSP00000452389

ENSP00000450780 ENSP00000450738 ENSP00000412990

XRCC3 Human Recombinant Protein Products:

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	OriGene Purified Proteins for XRCC3 OriGene Protein Over-expression Lysate for XRCC3 OriGene Custom MassSpec OriGene Custom Protein Services for XRCC3
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	Novus Biologicals XRCC3 Proteins Novus Biologicals XRCC3 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for XRCC3
	Search eBioscience for Proteins for XRCC3
	antibodies-online proteins for XRCC3 (7 products)
	antibodies-online peptides for XRCC3

XRCC3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of XRCC3
	Browse R&D Systems for Antibodies
	OriGene Antibodies for XRCC3 OriGene Custom Antibody Services for XRCC3
	Novus Biologicals XRCC3 Antibodies
	Abcam antibodies for XRCC3
	Cloud-Clone Corp. Antibodies for XRCC3
	ThermoFisher Antibodies for XRCC3
	antibodies-online antibodies for XRCC3 (84 products)

XRCC3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for XRCC3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for XRCC3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for XRCC3 Cloud-Clone Corp. CLIAs for XRCC3
	Search eBioscience for ELISAs for XRCC3
	antibodies-online kits for XRCC3 (7 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR020588 RecA_ATP-bd

IPR016467 DNA_recomb/repair_RecA-like

IPR027417 P-loop_NTPase

IPR013632 DNA_recomb/repair_Rad51_C

Graphical View of Domain Structure for InterPro Entry O43542

ProtoNet protein and cluster: O43542

UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542

Similarity: Belongs to the RecA family. RAD51 subfamily

Find genes that share domains with XRCC3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: XRCC3_HUMAN, O43542

Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair

chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number

under conditions of oxidative stress in the presence of RAD51 and RAD51C

Induction: Stress-induced increase in the mitochondrial levels is seen

Genatlas biochemistry entry for XRCC3:

repair X-ray defect,complementing defect in CHO cells,3,involved in recombinational repair,interacting with RAD51

for maintenance of genomic integrity

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000400	contributes to four-way junction DNA binding	IDA	--
GO:0003677	DNA binding	--	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0008094	DNA-dependent ATPase activity	IEA	--

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Phenotypes:
2 GenomeRNAi human phenotypes for XRCC3:

Synthetic lethal with cisplati

Upregulation of Wnt/beta-caten

1 MGI phenotypic allele

for Xrcc3 (no phenotypes)

Find genes that share phenotypes with XRCC3 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for XRCC3

miRNA Products:		Block miRNA regulation of human, mouse, rat XRCC3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate XRCC3
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Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for XRCC3
		Predesigned siRNA for gene silencing in human, mouse, rat XRCC3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for XRCC3

Clone Products:		OriGene clones in human, mouse for XRCC3 (see all 19) OriGene ORF clones in mouse, rat for XRCC3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): XRCC3 (NM_001100118)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XRCC3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XRCC3
		Browse ESI BIO Cell Lines and PureStem Progenitors for XRCC3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

XRCC3_HUMAN, O43542: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in

discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	5
nucleus	5
cytosol	2
cytoskeleton	1

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Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16215984
GO:0005657	replication fork	IDA	--
GO:0005737	cytoplasm	IDA	16215984
GO:0005739	mitochondrion	IDA	--
GO:0033065	Rad51C-XRCC3 complex	IDA	11751635

Find genes that share ontologies with XRCC3 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for XRCC3 About

See pathways by source

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SuperPath

Contained pathways About

Pyrimidine metabolism

Fluoropyrimidine Activity

0.69

Fluoropyrimidine Pathway, Pharmacodynamics

0.00

Homologous recombination

Homologous recombination

0.40

Integrated Breast Cancer Pathway

Integrated Breast Cancer Pathway

Find genes that share SuperPaths with XRCC3 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

2 BioSystems Pathways for XRCC3

	Fluoropyrimidine Activity
	Integrated Breast Cancer Pathway

1 PharmGKB Pathway for XRCC3

Fluoropyrimidine Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for XRCC3):

Homologous recombination

Pathway & Disease-focused RT² Profiler PCR Arrays including XRCC3:

DNA Damage Signaling Pathway in human mouse rat

DNA Repair in human mouse rat

Interactions:

GeneGlobe Interaction Network for XRCC3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for XRCC3 (O43542^{1, 3} ENSP00000343392⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 230)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FANCG	O15287³, ENSP00000367910⁴	I2D: score=3 STRING: ENSP00000367910
RAD51D	O75771³, ENSP00000378090⁴	I2D: score=2 STRING: ENSP00000378090
RAD51	Q06609³, ENSP00000267868⁴	I2D: score=1 STRING: ENSP00000267868
ZNHIT3	Q15649³, ENSP00000225410⁴	I2D: score=1 STRING: ENSP00000225410
RAD51C	O43502³, ENSP00000336701⁴	I2D: score=3 STRING: ENSP00000336701

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Gene Ontology (GO): Selected biological process terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000724	double-strand break repair via homologous recombination	IMP	--
GO:0000737	DNA catabolic process, endonucleolytic	IMP	14716019
GO:0006259	DNA metabolic process	--	--
GO:0006281	DNA repair	IGI	10422536
GO:0006310	DNA recombination	TAS	9660962

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for XRCC3

Selected Novoseek inferred chemical compound relationships for XRCC3 gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pcb 153	61	9	19069643 (2), 18948301 (1)
mitomycin c	42.3	3	7603995 (1), 17141189 (1)
cisplatin	33.2	8	15843498 (2), 16622263 (1), 17141189 (1)
folate	29	7	19177501 (2), 16997330 (2), 19360465 (1), 15066914 (1) (see all 5)
benzene	20.3	8	18095557 (3), 17535647 (2), 17605237 (2), 16728435 (1)
camptothecin	16.3	2	12584174 (2)
melphalan	13.1	7	11584063 (4), 15843498 (1)
n acetylcysteine	11.7	1	19069643 (1)
p003	1.68	2	12007561 (1), 12865926 (1)
methionine	0	2	17701750 (1), 12223443 (1)

5 PharmGKB related drug/compound annotations for XRCC3 gene About this table

Drug/compound	PharmGKB Annotation
cisplatin	CA
docetaxel	CA
fluorouracil	CA
irinotecan	CA
leucovorin	CA

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for XRCC3 gene (3 alternative transcripts):

NM_001100118.1 NM_001100119.1 NM_005432.3

Unigene Cluster for XRCC3:

X-ray repair complementing defective repair in Chinese hamster cells 3

Hs.592325 [show with all ESTs]

Unigene Representative Sequence: BX368160

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000554913(uc001yoa.4) ENST00000352127(uc001ynz.4) ENST00000554811

ENST00000553264 ENST00000555055(uc001ynx.4 uc001yny.4) ENST00000554974

ENST00000554774 ENST00000555451 ENST00000555832 ENST00000553807 ENST00000557439

ENST00000553361 ENST00000556980 ENST00000555964 ENST00000555231 ENST00000556682

ENST00000553332 ENST00000554170

miRNA Products:		Block miRNA regulation of human, mouse, rat XRCC3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate XRCC3
		SwitchGear 3'UTR luciferase reporter plasmid: XRCC3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for XRCC3
		Predesigned siRNA for gene silencing in human, mouse, rat XRCC3

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		GenScript: all cDNA clones in your preferred vector (see all 3): XRCC3 (NM_001100118)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XRCC3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC3

Primer Products:		OriGene qPCR primer pairs and template standards for XRCC3 OriGene qSTAR qPCR primer pairs in human, mouse for XRCC3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat XRCC3
		QuantiTect SYBR Green Assays in human, mouse, rat XRCC3
		QuantiFast Probe-based Assays in human, mouse, rat XRCC3

Additional mRNA sequence: BC073820.1

1 DOTS entry:

DT.100773069

Selected AceView cDNA sequences (see all 151):

BM797370 AA595441 AI983015 BX339303 BM557723 AU118580 CR605233 BM915097

BM796198 AK022829 BX325623 AU138697 BM803244 CB150648 BX385078 BM127755

AF035586 BM128018 BM905634 CR610241 CR613005 BE396817 AU124974 AK126706

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for XRCC3 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13
SP1:					-		-		-		-		-								-								-								-		-		-						-
SP2:											-		-								-								-
SP3:					-		-				-		-								-								-
SP4:					-		-		-		-		-								-								-
SP5:											-		-								-								-								-		-		-

ECgene alternative splicing isoforms for XRCC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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XRCC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACTGTGCAGC

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XRCC3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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XRCC3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.592325

Pathway & Disease-focused RT² Profiler PCR Arrays including XRCC3:

DNA Damage Signaling Pathway in human mouse rat

DNA Repair in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for XRCC3 OriGene qSTAR qPCR primer pairs in human, mouse for XRCC3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat XRCC3
		QuantiTect SYBR Green Assays in human, mouse, rat XRCC3
		QuantiFast Probe-based Assays in human, mouse, rat XRCC3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for XRCC3 gene from Selected species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Xrcc3^{1 , 5}	X-ray repair complementing defective repair in Chinese more^{1, 5}	76.97(n)¹ 73.7(a)¹		12 (61.14 cM)⁵ 74335¹ NM_028875.2¹ NP_083151.1¹ 111803192⁵
chicken (Gallus gallus)	Aves	XRCC3¹	X-ray repair complementing defective repair in Chinese more	62.34(n) 62.24(a)		423485 NM_001006489.1 NP_001006489.1
lizard (Anolis carolinensis)	Reptilia	XRCC3⁶	X-ray repair complementing defective repair in Chi...	52(a)	1 ↔ 1	1(6024977-6038048)
tropical clawed frog (Xenopus tropicalis)	Amphibia	xrcc3¹	X-ray repair complementing defective repair in Chinese more	58.41(n) 57.52(a)		548895 NM_001016141.2 NP_001016141.1
zebrafish (Danio rerio)	Actinopterygii	xrcc3¹	X-ray repair complementing defective repair in Chinese more	57.97(n) 53.33(a)		541414 NM_001013541.1 NP_001013559.1
fruit fly (Drosophila melanogaster)	Insecta	spn-B¹	spindle B	47.06(n) 39.92(a)		41746 NM_057392.5 NP_476740.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RAD57⁶	Protein that stimulates strand exchange by stabili...	15(a)	1 ↔ 1	IV(455201-456583) YDR004W
thale cress (Arabidopsis thaliana)	eudicotyledons	XRCC3¹	XRCC3	43.7(n) 38.19(a)		835850 NM_180871.1 NP_851202.1
rice (Oryza sativa)	Liliopsida	Os02g0562100¹	Os02g0562100	49.44(n) 39.17(a)		4329686 NM_001053685.1 NP_001047150.1

ENSEMBL Gene Tree for XRCC3 (if available)
TreeFam Gene Tree for XRCC3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201647595^1,2		--	84346512(+)	`AAAAA-/AAGAGAAG`	3	--	int¹		0	--	--	--	--
rs186258504^1,2	C	--	84346747(+)	`CTGCTA/GCCCCA`	3	--	int¹		0	--	--	--	--
rs139232122^1,2		--	84346839(+)	`GCTCTC/TTGCAA`	3	--	int¹		0	--	--	--	--
rs149958234^1,2		--	84346880(+)	`AGCCAA/GTGTCT`	3	--	int¹		0	--	--	--	--
rs3212092^1,2	C,F,H	--	84346937(-)	`CAGCTC/TAGACA`	3	--	int¹		9		NS EA NA	916
rs144189745^1,2		--	84346944(+)	`GCTGGA/GTGCCC`	3	--	int¹		0	--	--	--	--
rs861534^1,2	C,F,H	--	84346994(-)	`AAGACG/AGCCCT`	3	--	int¹		19		NS NA EA WA CSA	1068
rs861533^1,2	C,H	--	84347008(-)	`TTGCCT/CCTGAG`	3	--	int¹		16		EA NA WA CSA	424
rs3212090^1,2	C,F,O,H	--	84347156(-)	`GTGGGG/AAAGAG`	3	--	int¹ trp³		15		NS NA EA WA	1086
rs190721872^1,2		--	84347271(+)	`GAACAC/TGCTTC`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for XRCC3 (104163946 - 104181841 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for XRCC3 (see all 13): About this table

Variant ID	Type	Subtype	PubMed ID
esv2749175	CNV	Deletion	23290073
nsv902308	CNV	Loss	21882294
nsv902313	CNV	Loss	21882294
dgv1996n71	CNV	Loss	21882294
nsv902314	CNV	Loss	21882294
dgv1995n71	CNV	Loss	21882294
nsv470673	CNV	Loss	18288195
nsv902300	CNV	Loss	21882294
nsv902315	CNV	Loss	21882294
nsv527425	CNV	Loss	19592680

Human Gene Mutation Database (HGMD): XRCC3

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing XRCC3

DNA2.0 Custom Variant and Variant Library Synthesis for XRCC3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600675
OMIM disorders: 613972 114480
UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542

Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast

neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common

type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated

by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different

families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene

represented in this entry

Melanoma, cutaneous malignant 6 (CMM6) [MIM:613972]: A malignant neoplasm of melanocytes, arising de novo

or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.

Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

13 diseases for XRCC3:
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melanoma, cutaneous malignant, 6 breast cancer mutagen sensitivity breast cancer susceptibility

colorectal adenoma diffuse gastric cancer ovarian cancer oral submucous fibrosis

brca1 and brca2 hereditary breast and ovarian cancer lung cancer squamous cell carcinoma of the head and neck colorectal cancer

acute myeloid leukemia

4 inferred disease relationships from the University of Copenhagen DISEASES database for XRCC3:

Xeroderma pigmentosum Breast cancer Lung cancer Urinary bladder cancer

Find genes that share disorders with XRCC3 About GenesLikeMe

Selected Novoseek inferred disease relationships for XRCC3 gene (see all 26) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
xeroderma pigmentosum	53.3	4	16707649 (1), 18630471 (1), 19307510 (1), 17630853 (1)
chromosomal aberrations	49.7	5	16997330 (2), 17159780 (1), 17923529 (1)
cancer	48	23	16791138 (4), 9542526 (3), 16137195 (3), 16707649 (3) (see all 12)
bladder cancer	42.1	14	19815090 (2), 16284380 (2), 12223443 (1), 19429237 (1) (see all 7)
breast cancer	41.9	26	19426727 (4), 19886181 (3), 12565173 (2), 12023982 (2) (see all 14)
cancer lung	41.1	12	17034901 (3), 12618330 (2), 17705814 (2), 12917199 (1) (see all 8)
ataxia telangiectasia	31.1	1	16966185 (1)
skin cancer	30.3	2	15126335 (1), 16791138 (1)
genetic susceptibility	23.6	1	18543213 (1)
adenocarcinoma	21.9	4	16571649 (1), 16540687 (1), 18336773 (1)

Genetic Association Database (GAD): XRCC3
Human Genome Epidemiology (HuGE) Navigator: XRCC3 (267 documents)

Export disorders for XRCC3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for XRCC3 gene, integrated from 10 sources (see all 415):
(articles sorted by number of sources associating them with XRCC3)

Utopia: connect your pdf to the dynamic
world of online information

Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PubMed id 12023982)^{1, 2, 4, 9} Kuschel B....Dunning A. (Hum. Mol. Genet. 2002)
A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. (PubMed id 11059748)^{1, 2, 4, 9} Winsey S.L.... Welsh K.I. (Cancer Res. 2000)
XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. (PubMed id 14534887)^{1, 4, 9} Wang Y....Wu X. (Cancer 2003)
XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study. (PubMed id 19330829)^{1, 4, 9} Zhou K....Zhou L. (Int. J. Cancer 2009)
Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer. (PubMed id 19426727)^{1, 4, 9} Krupa R....Blasiak J. (Exp. Mol. Pathol. 2009)
Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. (PubMed id 16492913)^{1, 4, 9} Smedby K.E....Adami H.O. (amp 2006)
[Relationship between polymorphisms of DNA repair gene XRCC3 and susceptibility to lung cancer]. (PubMed id 18336773)^{1, 4, 9} Zhang Z.L....Su B. (Zhonghua Jie He He Hu Xi Za Zhi 2007)
[Association between genetic polymorphisms of DNA repair genes XRCC1, XPD, XRCC3 and the capacity of DNA repair induce by benzene]. (PubMed id 18095557)^{1, 4, 9} Xu J....Wang Q. (Wei Sheng Yan Jiu 2007)
Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to cytostatics. (PubMed id 17159780)^{1, 4, 9} MusA!k L....PAcc M. (Neuro Endocrinol. Lett. 2006)
XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. (PubMed id 16707649)^{1, 4, 9} Manuguerra M....Matullo G. (Am. J. Epidemiol. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7517	HGNC: 12830	AceView: XRCC3	Ensembl:ENSG00000126215	euGenes: HUgn7517
ECgene: XRCC3	Kegg: 7517	H-InvDB: XRCC3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for XRCC3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for XRCC3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/xrcc3/

Intellectual Property for XRCC3 gene
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Patent Information for XRCC3 gene:
Search GeneIP for patents involving XRCC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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