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Aliases for XRCC3 Gene

Aliases for XRCC3 Gene

  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 3 2 3
  • X-Ray Repair Cross-Complementing Protein 3 3 4
  • CMM6 3 6
  • DNA Repair Protein XRCC3 3
  • RAD51-Like 2

External Ids for XRCC3 Gene

Previous GeneCards Identifiers for XRCC3 Gene

  • GC14M101555
  • GC14M097979
  • GC14M102153
  • GC14M103233
  • GC14M104163
  • GC14M084342

Summaries for XRCC3 Gene

Entrez Gene Summary for XRCC3 Gene

  • This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for XRCC3 Gene

XRCC3 (X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 3) is a Protein Coding gene. Diseases associated with XRCC3 include melanoma, cutaneous malignant, 6 and mutagen sensitivity. Among its related pathways are Integrated Breast Cancer Pathway and Homologous recombination. GO annotations related to this gene include DNA-dependent ATPase activity and DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for XRCC3 Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Gene Wiki entry for XRCC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC3 Gene

Genomics for XRCC3 Gene

Regulatory Elements for XRCC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for XRCC3 Gene

Start:
103,697,608 bp from pter
End:
103,715,504 bp from pter
Size:
17,897 bases
Orientation:
Minus strand

Genomic View for XRCC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XRCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRCC3 Gene

Proteins for XRCC3 Gene

  • Protein details for XRCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43542-XRCC3_HUMAN
    Recommended name:
    DNA repair protein XRCC3
    Protein Accession:
    O43542
    Secondary Accessions:
    • O43568
    • Q9BU18

    Protein attributes for XRCC3 Gene

    Size:
    346 amino acids
    Molecular mass:
    37850 Da
    Quaternary structure:
    • Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.

neXtProt entry for XRCC3 Gene

Proteomics data for XRCC3 Gene at MOPED

Post-translational modifications for XRCC3 Gene

  • Ubiquitination at Lys172
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for XRCC3 Gene

Domains for XRCC3 Gene

Protein Domains for XRCC3 Gene

Graphical View of Domain Structure for InterPro Entry

O43542

UniProtKB/Swiss-Prot:

XRCC3_HUMAN :
  • O43542
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with XRCC3: view

No data available for Gene Families for XRCC3 Gene

Function for XRCC3 Gene

Molecular function for XRCC3 Gene

GENATLAS Biochemistry:
repair X-ray defect,complementing defect in CHO cells,3,involved in recombinational repair,interacting with RAD51 for maintenance of genomic integrity
UniProtKB/Swiss-Prot Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
UniProtKB/Swiss-Prot Induction:
Stress-induced increase in the mitochondrial levels is seen.

Gene Ontology (GO) - Molecular Function for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000400 contributes_to four-way junction DNA binding IDA 20207730
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 11751635
GO:0005524 ATP binding IEA --
GO:0008094 DNA-dependent ATPase activity IEA --
genes like me logo Genes that share ontologies with XRCC3: view

Phenotypes for XRCC3 Gene

genes like me logo Genes that share phenotypes with XRCC3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XRCC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XRCC3 Gene

Localization for XRCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRCC3 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XRCC3 Gene COMPARTMENTS Subcellular localization image for XRCC3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16215984
GO:0005657 replication fork IDA 20207730
GO:0005737 cytoplasm IDA 16215984
GO:0005739 mitochondrion IDA 20413593
GO:0033065 Rad51C-XRCC3 complex IDA 11751635
genes like me logo Genes that share ontologies with XRCC3: view

Pathways for XRCC3 Gene

genes like me logo Genes that share pathways with XRCC3: view

Pathways by source for XRCC3 Gene

2 BioSystems pathways for XRCC3 Gene
1 PharmGKB pathway for XRCC3 Gene
1 KEGG pathway for XRCC3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 23149936
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006200 obsolete ATP catabolic process --
GO:0006259 DNA metabolic process --
GO:0006281 DNA repair IGI 10422536
genes like me logo Genes that share ontologies with XRCC3: view

Compounds for XRCC3 Gene

(11) Novoseek inferred chemical compound relationships for XRCC3 Gene

Compound -log(P) Hits PubMed IDs
pcb 153 61 3
mitomycin c 42.3 2
cisplatin 33.2 4
folate 29 7
benzene 20.3 8

(5) PharmGKB related drug/compound annotations for XRCC3 Gene

Drug/compound Annotation
cisplatin CA
docetaxel CA
fluorouracil CA
irinotecan CA
leucovorin CA
genes like me logo Genes that share compounds with XRCC3: view

Transcripts for XRCC3 Gene

Unigene Clusters for XRCC3 Gene

X-ray repair complementing defective repair in Chinese hamster cells 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XRCC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XRCC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - -
SP11: - - - -
SP12: - - - -
SP13:

Relevant External Links for XRCC3 Gene

GeneLoc Exon Structure for
XRCC3
ECgene alternative splicing isoforms for
XRCC3

Expression for XRCC3 Gene

mRNA expression in normal human tissues for XRCC3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XRCC3 Gene

SOURCE GeneReport for Unigene cluster for XRCC3 Gene Hs.592325

genes like me logo Genes that share expressions with XRCC3: view

Expression partners for XRCC3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for XRCC3 Gene

Orthologs for XRCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XRCC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XRCC3 35
  • 79.09 (n)
  • 76.63 (a)
XRCC3 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XRCC3 35
  • 82.61 (n)
  • 76.23 (a)
XRCC3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xrcc3 35
  • 76.97 (n)
  • 73.7 (a)
Xrcc3 16
Xrcc3 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XRCC3 35
  • 99.33 (n)
  • 99.71 (a)
XRCC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102551085 35
  • 77.52 (n)
  • 74.78 (a)
oppossum
(Monodelphis domestica)
Mammalia XRCC3 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XRCC3 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves XRCC3 35
  • 62.34 (n)
  • 62.24 (a)
XRCC3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XRCC3 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xrcc3 35
  • 58.41 (n)
  • 57.52 (a)
zebrafish
(Danio rerio)
Actinopterygii xrcc3 35
  • 57.97 (n)
  • 53.33 (a)
xrcc3 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013180 35
  • 45.18 (n)
  • 36.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta spn-B 35
  • 47.06 (n)
  • 39.92 (a)
spn-B 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD57 36
  • 15 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons XRCC3 35
  • 43.7 (n)
  • 38.19 (a)
rice
(Oryza sativa)
Liliopsida Os02g0562100 35
  • 49.44 (n)
  • 39.17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01771 35
  • 48.35 (n)
  • 38.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp57 35
  • 38.51 (n)
  • 29.19 (a)
Species with no ortholog for XRCC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRCC3 Gene

ENSEMBL:
Gene Tree for XRCC3 (if available)
TreeFam:
Gene Tree for XRCC3 (if available)

Paralogs for XRCC3 Gene

No data available for Paralogs for XRCC3 Gene

Variants for XRCC3 Gene

Sequence variations from dbSNP and Humsavar for XRCC3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs709401 -- 103,705,608(-) GCCAC(C/T)GTGAC intron-variant
rs861529 -- 103,712,977(-) TCGTC(A/G)CTAAA intron-variant
rs861530 -- 103,707,786(-) ACCGC(A/G)TGTCC intron-variant
rs861531 -- 103,706,470(-) GTGAG(G/T)AGGAG intron-variant
rs861532 -- 103,704,004(-) gacgt(G/T)ctttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XRCC3 Gene

Variant ID Type Subtype PubMed ID
nsv902300 CNV Loss 21882294
nsv902308 CNV Loss 21882294
dgv1995n71 CNV Loss 21882294
dgv658e1 CNV Complex 17122850
nsv527425 CNV Loss 19592680
nsv470673 CNV Loss 18288195
nsv902313 CNV Loss 21882294
nsv902314 CNV Loss 21882294
nsv902315 CNV Loss 21882294
esv2749175 CNV Deletion 23290073
dgv1996n71 CNV Loss 21882294
nsv9171 CNV Gain 18304495
nsv827071 CNV Gain 20364138

Relevant External Links for XRCC3 Gene

HapMap Linkage Disequilibrium report
XRCC3
Human Gene Mutation Database (HGMD)
XRCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC3 Gene

Disorders for XRCC3 Gene

(2) OMIM Diseases for XRCC3 Gene (600675)

UniProtKB/Swiss-Prot

XRCC3_HUMAN
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:12023982}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Melanoma, cutaneous malignant 6 (CMM6) [MIM:613972]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. {ECO:0000269 PubMed:11059748}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for XRCC3 Gene

(26) Novoseek inferred disease relationships for XRCC3 Gene

Disease -log(P) Hits PubMed IDs
xeroderma pigmentosum 53.3 4
chromosomal aberrations 49.7 4
cancer 48 22
bladder cancer 42.1 9
breast cancer 41.9 23

Relevant External Links for XRCC3

Genetic Association Database (GAD)
XRCC3
Human Genome Epidemiology (HuGE) Navigator
XRCC3
genes like me logo Genes that share disorders with XRCC3: view

No data available for Genatlas for XRCC3 Gene

Publications for XRCC3 Gene

  1. A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. (PMID: 11059748) Winsey S.L. … Welsh K.I. (Cancer Res. 2000) 3 4 23 48
  2. Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PMID: 12023982) Kuschel B. … Dunning A. (Hum. Mol. Genet. 2002) 3 4 23 48
  3. Screening of homologous recombination gene polymorphisms in lung cancer patients reveals an association of the NBS1-185Gln variant and p53 gene mutations. (PMID: 12917199) Medina P.P. … Sanchez-Cespedes M. (Cancer Epidemiol. Biomarkers Prev. 2003) 3 23 48
  4. XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. (PMID: 14534887) Wang Y. … Wu X. (Cancer 2003) 3 23 48
  5. DNA-repair genetic polymorphisms and breast cancer risk. (PMID: 14652281) Smith T.R. … Hu J.J. (Cancer Epidemiol. Biomarkers Prev. 2003) 3 23 48

Products for XRCC3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate XRCC3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for XRCC3
    • Block miRNA regulation of XRCC3 using miScript Target Protectors

    Sources for XRCC3 Gene

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