XRCC3 Gene
protein-coding GIFtS: 60
GCID: GC14M104163
|
|
X-ray repair complementing defective repair in Chinese hamster...
| |
Aliases
for XRCC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 31 2 | | X-Ray Repair Cross-Complementing Protein 32 3 | | CMM62 5 | | DNA Repair Protein XRCC32 |
Export aliases for XRCC3 gene to outside databasesPrevious GC identifers: GC14M101555 GC14M097979 GC14M102153 GC14M103233 GC14M084342 |
Summaries
for XRCC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XRCC3:
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination tomaintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, arepair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and ischromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients ofvarying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repairchromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy numberunder conditions of oxidative stress in the presence of RAD51 and RAD51C
Gene Wiki entry for XRCC3
|
Genomic Views
for XRCC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XRCC3 gene promoter:
CHOP-10 GR PPAR-gamma1 p53 GR-beta PPAR-gamma2 GR-alpha C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for XRCC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.3 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.3XRCC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M104163: view genomic region
(about GC identifiers)
Start:
|
104,163,946 bp from pter |
End:
|
104,181,841 bp from pter |
Size:
|
17,896 bases |
Orientation:
|
minus strand |
|
Proteins
for XRCC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542 (See
protein sequence)Recommended Name: DNA repair protein XRCC3 Size: 346 amino acids; 37850 Da
Subunit: Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3.Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologousrecombination repair
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discretenuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair
Secondary accessions: O43568 Q9BU18Explore the universe of human proteins at neXtProt for XRCC3: NX_O43542
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43542
XRCC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001093588.1 NP_001093589.1 NP_005423.1
ENSEMBL proteins: ENSP00000451362 ENSP00000343392 ENSP00000451974 ENSP00000452598 ENSP00000451361 ENSP00000451118 ENSP00000451252 ENSP00000451173 ENSP00000452389 ENSP00000450780 ENSP00000450738 ENSP00000412990
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
XRCC3 for ontologies About GeneDecksing
XRCC3 Antibody Products:
Assay Products for XRCC3: |
Protein
Domains /
Families
for XRCC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XRCC3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43542ProtoNet protein and cluster: O43542 UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542Similarity: Belongs to the RecA family. RAD51 subfamily |
Function
for XRCC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repairchromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy numberunder conditions of oxidative stress in the presence of RAD51 and RAD51CInduction: Stress-induced increase in the mitochondrial levels is seen Genatlas biochemistry entry for XRCC3:repair X-ray defect,complementing defect in CHO cells,3,involved in recombinational repair,interacting with RAD51 formaintenance of genomic integrity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): XRCC3 (NM_001100118) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
XRCC3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for XRCC3:
|
Pathways & Interactions
for XRCC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Fluoropyrimidine Activity | | | 2 | Integrated Breast Cancer Pathway | | | 3 | Homologous recombination | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for XRCC3
1  PharmGKB Pathway for XRCC3
1 
Kegg Pathway (Kegg details for XRCC3):
XRCC3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XRCC3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/15 Interacting proteins for XRCC3 (O435421, 3 ENSP000003433924) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
XRCC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for XRCC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
XRCC3 for compounds About GeneDecksing
 Browse Tocris compounds for XRCC3
10/11 Novoseek chemical compound relationships for XRCC3 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pcb 153 |
61 |
9 |
19069643 (2), 18948301 (1) |
| mitomycin c |
42.3 |
3 |
7603995 (1), 17141189 (1) |
| cisplatin |
33.2 |
8 |
15843498 (2), 16622263 (1), 17141189 (1) |
| folate |
29 |
7 |
19177501 (2), 16997330 (2), 19360465 (1), 15066914 (1) (see all 5) |
| benzene |
20.3 |
8 |
18095557 (3), 17535647 (2), 17605237 (2), 16728435 (1) |
| camptothecin |
16.3 |
2 |
12584174 (2) |
| melphalan |
13.1 |
7 |
11584063 (4), 15843498 (1) |
| n acetylcysteine |
11.7 |
1 |
19069643 (1) |
| p003 |
1.68 |
2 |
12007561 (1), 12865926 (1) |
| methionine |
0 |
2 |
17701750 (1), 12223443 (1) |
Search CenterWatch for drugs/clinical trials and news about XRCC3
|
Transcripts
for XRCC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XRCC3 gene (3 alternative transcripts): NM_001100118.1 NM_001100119.1 NM_005432.3 Unigene Clusters for XRCC3: X-ray repair complementing defective repair in Chinese hamster cells 3 Hs.592325 [show with all ESTs], Hs.733412 [show with all ESTs]Unigene Representative Sequences: BX368160, AK12449818/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000554913(uc001yoa.4) ENST00000352127(uc001ynz.4) ENST00000554811
ENST00000553264 ENST00000555055(uc001ynx.4 uc001yny.4) ENST00000554974
ENST00000554774 ENST00000555451 ENST00000555832 ENST00000553807 ENST00000557439
ENST00000553361 ENST00000556980 ENST00000555964 ENST00000555231 ENST00000556682
ENST00000553332 ENST00000554170
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): XRCC3 (NM_001100118) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC3 |
Additional cDNA sequence: AF035586.1 AK022829.1 AK023646.1 AK124498.1 AK296465.1 BC001036.1 BC002949.1 BC011725.2 BT007417.1 BX161398.1 19 DOTS entries: DT.99936700 DT.102838411 DT.100773069 DT.408842 DT.120790634 DT.75146282 DT.92051759 DT.100797026 DT.120790785 DT.100797028 DT.92063298 DT.432421 DT.120790878 DT.91974123 DT.95372736 DT.100693953 DT.100700104 DT.100762829 DT.95372738 151 AceView cDNA sequences (see top 24): BE396817 BM915097 BU182143 BX385078 AU138697 BM682035 AU124974 BM127755 AK022829 BM557723 AK126706 BM128018 CR603680 BX375448 BC073820 BC011725 BC002949 BQ213513 CR610241 CB048579 BC001036 AU118580 CB150648 AL526291 BX339303 BX333561 BM803244 CR605233 BM976502 BM905634 AA595441 BX388125 BM798032 AA877848 BM797370 CR613005 BX325623 BM796198 AF035586 BX161398 CR622268 AI983015 BI255133 NM_005432 AL044657 BX368160 BX401930 BX347078 BM792955 BT007417 BI116179 BG176868 BX347046 BM743534 AW015800 BG325857 AK124498 BX339302 BF982984 BX391032 BX375506 BX326062 BE614119 BQ641864 AU124480 BX388530 AU150108 BG758685 BX388124 BE279092 AW205373 BX346825 BQ423449 BM480190 BG328447 BM471746 BP365138 BG323254 BE393716 BX375507 BX429925 BX346820 BV183212 BE514396 AK023646 BQ676414 BV183213 BX347451 BG421265 AL526254 BM764874 BE616069 BX368106 CA488257 BE902152 AA459013 BX325622 BM729106 BM051850 BF974659 BQ878685 BX443240 BE906860 BV208286 CA395545 BQ051807 BG480914 BG031361 BQ887552 BI253435 CD558148 BI030945 AU150409 BF115342 BE560130 BE561209 CA416223 AA459237 BQ072342 BF306430 BE614579 BE296684 BX346804 AA251013 BE616788 BX388541 BI225452 AU145105 BX333560 AU148732 BU430489 BG762925 CF138503 BF855751 AI571318 AI990435 BI857022 CB048578 AU127549 BF883474 AW182785 AI580821 BI918561 BI914989 AA251211 BX347315 BF329446 BQ716102 BF305177 BM798503 AI890005
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC3 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | - | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for XRCC3
|
Expression
for XRCC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XRCC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTGCAGC
About this image
See XRCC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XRCC3
SOURCE GeneReport for Unigene clusters: Hs.592325 Hs.733412
SABiosciences Expression via Pathway-Focused PCR Arrays including XRCC3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRCC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XRCC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC3 |
Orthologs
for XRCC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for XRCC3 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for XRCC3 (if available)
TreeFam Gene Tree for XRCC3 (if available) |
Paralogs
for XRCC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for XRCC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XRCC3 (104163946 - 104181841 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for XRCC3
1 CNV: 3949
1 Indel: 33277
Human Gene Mutation Database (HGMD): XRCC3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRCC3 |
|
Disorders
/ Diseases
for XRCC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XRCC3 for disorders About GeneDecksing
OMIM gene information: 600675
OMIM disorders: --
UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542
Defects in XRCC3 are the cause of susceptibility to breast cancer (BC) [MIM:114480]. BC is a common malignancyoriginating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasiveductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous.Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more thanone locus can be involved in different families or even in the same case Defects in XRCC3 are the cause of susceptibility to cutaneous malignant melanoma type 6 (CMM6) [MIM:613972].CMM6 is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs mostoften in the skin but also may involve other sites
20/86  diseases for XRCC3 (see all 86): About MalaCardsdiffuse large b-cell lymphoma xeroderma pigmentosum b-cell lymphomas acoustic neuroma
mutagen sensitivity non-hodgkin lymphoma soft tissue sarcoma spina bifida
ataxia telangiectasia orofacial cleft squamous cell carcinoma biliary tract cancer
breast cancer susceptibility urinary bladder cancer cutaneous malignant melanoma oral squamous cell carcinoma
breast cancer squamous cell carcinoma of the head and neck neuroma systemic lupus erythematosus
4 diseases from the University of Copenhagen DISEASES database for XRCC3:Xeroderma pigmentosum Breast cancer Urinary bladder cancer Lung cancer 10/26 Novoseek disease relationships for XRCC3 gene (see all 26) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| xeroderma pigmentosum |
53.3 |
4 |
16707649 (1), 18630471 (1), 19307510 (1), 17630853 (1) |
| chromosomal aberrations |
49.7 |
5 |
16997330 (2), 17159780 (1), 17923529 (1) |
| cancer |
48 |
23 |
16791138 (4), 9542526 (3), 16137195 (3), 16707649 (3) (see all 12) |
| bladder cancer |
42.1 |
14 |
19815090 (2), 16284380 (2), 12223443 (1), 19429237 (1) (see all 7) |
| breast cancer |
41.9 |
26 |
19426727 (4), 19886181 (3), 12565173 (2), 12023982 (2) (see all 14) |
| cancer lung |
41.1 |
12 |
17034901 (3), 12618330 (2), 17705814 (2), 12917199 (1) (see all 8) |
| ataxia telangiectasia |
31.1 |
1 |
16966185 (1) |
| skin cancer |
30.3 |
2 |
15126335 (1), 16791138 (1) |
| genetic susceptibility |
23.6 |
1 |
18543213 (1) |
| adenocarcinoma |
21.9 |
4 |
16571649 (1), 16540687 (1), 18336773 (1) |
Genetic Association Database (GAD): XRCC3
Human Genome Epidemiology (HuGE) Navigator: XRCC3 (267 documents)
Export disorders for XRCC3 gene to outside databases
|
Publications
for XRCC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XRCC3 gene, integrated from 9 sources (see all 375):
(articles sorted by number of sources associating them with XRCC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PubMed id 12023982)1, 2, 4, 9 Kuschel B....Dunning A. (2002)
- A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. (PubMed id 11059748)1, 2, 4, 9 Winsey S.L.... Welsh K.I. (2000)
- XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. (PubMed id 14534887)1, 4, 9 Wang Y....Wu X. (2003)
- Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors: association with late clinical radiosensitivity and cancer incidence. (PubMed id 16137195)1, 4, 9 De Ruyck K....Thierens H. (2005)
- Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (PubMed id 15491645)1, 4, 9 Aka P....Kirsch-Volders M. (2004)
- XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. (PubMed id 9660962)1, 2, 9 Liu N....Thompson L.H. (1998)
- Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. (PubMed id 9542526)1, 4, 9 Price E.A....Arrand J.E. (1997)
- Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. (PubMed id 16215984)1, 2, 9 Bennett B.T. and Knight K.L. (2005)
- An association of polymorphism of DNA repair genes XRCC1 and XRCC3 with colorectal cancer. (PubMed id 15354414)1, 4, 9 Krupa R. and Blasiak J. (2004)
- An assessment of a variant of the DNA repair gene XRCC3 as a possible nevus or melanoma susceptibility genotype. (PubMed id 15009726)1, 4, 9 Bertram C.G....Newton Bishop J.A. (2004)
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External Searches for XRCC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing XRCC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing XRCC3 gene
(According to HUGE)
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Specialized Databases showing XRCC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for XRCC3 gene:
Search GeneIP for patents involving XRCC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for XRCC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for XRCC3 | | OriGene shRNA RFP for XRCC3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XRCC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRCC3 | | | OriGene Protein Over-expression Lysate for XRCC3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XRCC3 | | OriGene 3'-UTR Clone for XRCC3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XRCC3 | | OriGene Custom Protein Services for XRCC3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XRCC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRCC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRCC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC3 |
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| | | | Search Tocris compounds for XRCC3 |
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 | | | XRCC3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC3 |
|  |  |  | | | | ThermoFisher Antibodies for XRCC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC3 |
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