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XRCC3 Gene

protein-coding GIFtS: 62

GC14M103233

X-ray repair complementing defective repair in Chinese hamster cells 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
RAD51-like ^²

Descriptions
DNA repair protein XRCC3 ^²
X-ray repair complementing defective repair in Chinese hamster cells 3 ^²
X-ray repair cross complementing protein 3 ^²
X-ray repair cross-complementing protein 3 ^³

External Ids
HGNC: 12830¹
Entrez Gene: 7517²
UniProtKB: O43542³
Ensembl: ENSG00000126215⁷

Search outside databases for aliases for XRCC3 gene

Previous GC identifers: GC14M101555 GC14M097979 GC14M102153

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XRCC3:

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous

recombination to maintain chromosome stability and repair DNA damage. This gene functionally

complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a

number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite

polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Alternatively spliced transcript variants encoding the same protein have been identified.

[provided by RefSeq]

UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542

Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA,

thought to repair chromosomal fragmentation, translocations and deletions

Gene Wiki entry for XRCC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XRCC3 gene

Entrez Gene cytogenetic band: 14q32.3 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.3

XRCC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M103233: (about GC identifiers)

Start:	103,233,707 bp from pter
End:	103,251,576 bp from pter
Size:	17,870 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542 (See protein sequence)

Recommended Name: DNA repair protein XRCC3

Size: 346 amino acids; 37850 Da

Subunit: Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D,

XRCC2 and XRCC3

Subcellular location: Nucleus (Probable)

Secondary accessions: O43568 Q9BU18

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001093588.1 NP_001093589.1 NP_005423.1

ENSEMBL proteins:

ENSP00000343392

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XRCC3)
	Human Recombinant Proteins from Abnova (XRCC3)

OriGene Purified Recombinant Human Protein: XRCC3

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for XRCC3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XRCC3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (XRCC3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XRCC3)
	Novus Biologicals Antibodies for XRCC3

Assays for XRCC3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O43542

ProtoNet protein and cluster: O43542

UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542

Similarity: Belongs to the recA family. RAD51 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRCC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XRCC3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005432

Applied Biosystems Silencer® siRNAs for XRCC3

Sigma-Aldrich siRNA and siRNA Panels for XRCC3

Sigma-Aldrich shRNA Panels and shRNA for XRCC3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XRCC3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001100118
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001100118
untagged cDNA clones in CMV expression vector (see all 3): NM_001100118

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001100119

UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542

Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA,

thought to repair chromosomal fragmentation, translocations and deletions

Genatlas biochemistry entry for XRCC3:

repair X-ray defect,complementing defect in CHO cells,3,involved in recombinational

repair,interacting with RAD51 for maintenance of genomic integrity

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008094	DNA-dependent ATPase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for XRCC3

5/35 Interacting proteins for XRCC3 (ENSP00000343392³) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAD51C	ENSP00000336701³	STRING (score=.996)
XRCC2	ENSP00000352271³	STRING (score=.993)
FANCG	ENSP00000367910³	STRING (score=.978)
NAT2	ENSP00000286479³	STRING (score=.885)
XRCC4	ENSP00000342011³	STRING (score=.844)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	TAS	9660962
GO:0006310	DNA recombination	TAS	9660962
GO:0006974	response to DNA damage stimulus	TAS	7603995

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XRCC3
4 Novoseek chemical compound relationships for XRCC3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pcb 153	63.82	7	19069643 (2), 18948301 (1)
benzene	23.25	8	18095557 (3), 17535647 (2), 17605237 (2), 16728435 (1)
p003	3.56	2	12007561 (1), 12865926 (1)
methionine	0.00	2	17701750 (1), 12223443 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRCC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XRCC3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005432

Sigma-Aldrich siRNA and siRNA Panels for XRCC3

Sigma-Aldrich shRNA Panels and shRNA for XRCC3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001100118 NM_001100119 NM_005432

REFSEQ mRNAs for XRCC3 gene (3 alternative transcripts):

NM_001100118.1 NM_001100119.1 NM_005432.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001100118 NM_001100119 NM_005432

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001100118
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001100118
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001100118

Additional cDNA sequence:

AF035586.1 AK022829.1 AK023646.1 AK124498.1 AK296465.1 BC001036.1 BC002949.1 BC011725.2

BT007417.1 BX161398.1 CR603680.1 CR605233.1 CR610241.1 CR613005.1 CR622268.1

19 DOTS entries:

DT.99936700 DT.102838411 DT.100773069 DT.408842 DT.120790634 DT.75146282 DT.92051759 DT.120790785

DT.100797026 DT.100797028 DT.92063298 DT.432421 DT.120790878 DT.91974123 DT.95372736 DT.100693953

DT.100700104 DT.100762829 DT.95372738

24/151 AceView cDNA sequences (see all 151 ):

BM127755 BX333561 AK022829 BX161398 BX325623 AU138697 AI983015 BC011725

BX339303 CR605233 AA595441 AF035586 CR613005 CR610241 BM905634 AA877848

AK126706 BM803244 BM976502 AU118580 BM797370 BX375448 CR622268 BE396817

highest scoring ESTs for XRCC3:

BF305177 BF306430 BG176868 BG421265 AK022829 AK023646 BC001036 BC011725 BX161398 BX339303

Unigene Cluster for XRCC3:

X-ray repair complementing defective repair in Chinese hamster cells 3

Hs.719391 [show with all ESTs]

Unigene Representative Sequence: AK124498

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC3 (see all 13 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13
SP1:					-		-		-		-		-								-								-								-		-		-						-
SP2:											-		-								-								-
SP3:					-		-				-		-								-								-
SP4:					-		-		-		-		-								-								-
SP5:											-		-								-								-								-		-		-

About this scheme

ECgene alternative splicing isoforms for XRCC3

1 Ensembl transcript including schematic representation:

ENST00000352127

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XRCC3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XRCC3

¹ / ² / ³

3 probe-sets matching XRCC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37094_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF035586	0.80	0.80	0.80	1
216299_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK022829	0.80	0.88	0.84	1
216299_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719391
Expression variation in blood from EXPOLDB for XRCC3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XRCC3 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	Xrcc3^{1, 5}	12⁵	X-ray repair complementing defective repair in Chinese more^{1, 5}	76.97(n)¹ 73.7(a)¹	74335¹ NM_028875.2¹ NP_083151.1¹ AI182522⁵ AK014491⁵ (see all 8)
chicken (Gallus gallus)	XRCC3¹	--	X-ray repair complementing defective repair in Chinese more	62.34(n) 62.24(a)	423485 NM_001006489.1 NP_001006489.1
zebrafish (Danio rerio)	xrcc3¹	--	X-ray repair complementing defective repair in Chinese more	57.97(n) 53.33(a)	541414 NM_001013541.1 NP_001013559.1
fruit fly (Drosophila melanogaster)	spn-B¹	--	spindle B	47.06(n) 39.92(a)	41746 NM_057392.3 NP_476740.1
African malaria mosquito (Anopheles gambiae)	ENSANGG00000012610¹	--	ENSANGP00000015099	46.57(n) 36.27(a)	1271451 XM_310247.2 XP_310247.2

About this table Species with no ortholog for XRCC3

ENSEMBL Gene Tree for XRCC3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XRCC3 gene

DMC1² RAD51²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/111 NCBI SNPs in XRCC3 are shown (see all 111 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 114)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1799794^1,2	C,F,H	103249020(-)	`GCAGGA/GTGTGC`	3	--	ut5¹ int¹		12	EA NS MN EU WA CSAM	2632
	rs3212057^1,2	F,H	103243218(-)	`GCTCCG/ACGGTG`	3	H/R	mis¹ ese³		5	NS EU EA WA	572
	rs861531^1,2	A,C,F,H,O	103242560(-)	`GTGAGG/TAGGAG`	3	--	int¹ trp³		12	NS MN EU EA WA	1446
	rs3212090^1,2	C,F,H,O	103238616(-)	`GTGGGG/AAAGAG`	3	--	int¹ trp³		8	NS NA EU EA WA	720
	rs861532^1,2	A,C,F,H	103240094(-)	`gacgtG/Tctttc`	3	--	int¹ trp³		5	EU EA WA NS	598
	rs861530^1,2	A,C,F,H	103243876(-)	`ACCGCG/ATGTCC`	3	--	int¹		12	EA NA EU WA NS	968
--	rs861529^1,2	A,C,F	103249067(-)	`TCGTCG/ACTAAA`	3	--	int¹		12	NS MN CSAM EA	1232
	rs3212064^1,2	C,F,H	103242006(-)	`TTACCG/CCACGG`	3	--	int¹		11	NS EU EA WA	1254
	rs3212079^1,2	C,F,H	103240218(-)	`ACTGCC/TTTCCC`	3	--	int¹ trp³		15	NS EU EA WA	1672
	rs861534^1,2	C,F,H	103238454(-)	`AAGACG/AGCCCT`	3	--	int¹		8	NS NA EU EA WA	694

About this table

HapMap Linkage Disequilibrium images for XRCC3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600675

UniProtKB/Swiss-Prot: XRCC3_HUMAN, O43542

Met-241 is associated with the development of cutaneous malignant melanoma

10/25 Novoseek disease relationships for XRCC3 gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
xeroderma pigmentosum	55.15	4	16707649 (1), 18630471 (1), 19307510 (1), 17630853 (1)
chromosomal aberrations	49.98	5	16997330 (2), 17159780 (1), 17923529 (1)
cancer	48.08	22	16791138 (4), 9542526 (3), 16137195 (3), 16707649 (3) (see all 11)
cancer lung	43.72	12	17034901 (3), 12618330 (2), 17705814 (2), 12917199 (1) (see all 8)
bladder cancer	38.22	7	16284380 (2), 12223443 (1), 16652373 (1), 19414392 (1) (see all 6)
breast cancer	36.47	16	12565173 (2), 12023982 (2), 18188695 (2), 17701750 (1) (see all 11)
ataxia telangiectasia	33.46	1	16966185 (1)
skin cancer	33.16	2	15126335 (1), 16791138 (1)
genetic susceptibility	26.38	1	18543213 (1)
carcinoma basal cell	21.94	2	15126335 (1), 18067130 (1)

About this table

Human Gene Mutation Database: XRCC3
Genetic Association Database: XRCC3
Human Genome Epidemiology Navigator: XRCC3 (189 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/273 PubMed articles for XRCC3 gene (see all 273 ):

A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. (PubMed id 11059748)^{1, 3, 4, 6} Winsey S.L.... Welsh K.I. (2000)
XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. (PubMed id 14534887)^{1, 3, 6} Wang Y....Wu X. (2003)
Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors: association with late clinical radiosensitivity and cancer incidence. (PubMed id 16137195)^{1, 3, 6} De Ruyck K....Thierens H. (2005)
Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (PubMed id 15491645)^{1, 3, 6} Aka P....Kirsch-Volders M. (2004)
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. (PubMed id 9660962)^{1, 3, 4} Liu N....Thompson L.H. (1998)
Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. (PubMed id 9542526)^{1, 3, 6} Price E.A....Arrand J.E. (1997)
An association of polymorphism of DNA repair genes XRCC1 and XRCC3 with colorectal cancer. (PubMed id 15354414)^{1, 3, 6} Krupa R. and Blasiak J. (2004)
An assessment of a variant of the DNA repair gene XRCC3 as a possible nevus or melanoma susceptibility genotype. (PubMed id 15009726)^{1, 3, 6} Bertram C.G....Newton Bishop J.A. (2004)
Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PubMed id 12023982)^{1, 3, 6} Kuschel B....Dunning A. (2002)
DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. (PubMed id 15386379)^{1, 3, 6} Benhamou S....Hirvonen A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7517	HGNC: 12830	AceView: XRCC3	Ensembl:ENSG00000126215	euGenes: HUgn7517
ECgene: XRCC3	H-InvDB: XRCC3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for XRCC3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/xrcc3/

Licensable Technologies for XRCC3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for XRCC3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XRCC3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XRCC3		Antibodies for XRCC3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XRCC3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (XRCC3)
	Antibodies (XRCC3)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (XRCC3)
	Antibodies (XRCC3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for XRCC3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for XRCC3

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XRCC3 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for XRCC3

Summaries
for XRCC3

Genomic Location
for XRCC3

Proteins
for XRCC3

Protein Domains/
Families
for XRCC3

Gene Function
for XRCC3

Pathways & Interactions
for XRCC3

Drugs & Compounds
for XRCC3

Transcripts
for XRCC3

Expression
for XRCC3

Orthologs
for XRCC3

Paralogs
for XRCC3

SNPs/Variants
for XRCC3

Disorders & Mutations
for XRCC3

Medical News
for XRCC3

Publications
for XRCC3

Search for XRCC3

Genome Databases showing XRCC3

Other Databases showing XRCC3

Specialized Databases showing XRCC3

Licensable Technologies
for XRCC3

Services
for XRCC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XRCC3 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor XRCC3

Summariesfor XRCC3

Genomic Locationfor XRCC3

Proteinsfor XRCC3

Protein Domains/Familiesfor XRCC3

Gene Functionfor XRCC3

Pathways & Interactionsfor XRCC3

Drugs & Compoundsfor XRCC3

Transcriptsfor XRCC3

Expression for XRCC3

Orthologsfor XRCC3

Paralogsfor XRCC3

SNPs/Variantsfor XRCC3

Disorders & Mutationsfor XRCC3

Medical Newsfor XRCC3

Publicationsfor XRCC3

Search for XRCC3

Genome Databases showing XRCC3

Other Databases showing XRCC3

Specialized Databases showing XRCC3

Licensable Technologiesfor XRCC3

Servicesfor XRCC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XRCC3

Summaries
for XRCC3

Genomic Location
for XRCC3

Proteins
for XRCC3

Protein Domains/
Families
for XRCC3

Gene Function
for XRCC3

Pathways & Interactions
for XRCC3

Drugs & Compounds
for XRCC3

Transcripts
for XRCC3

Expression
for XRCC3

Orthologs
for XRCC3

Paralogs
for XRCC3

SNPs/Variants
for XRCC3

Disorders & Mutations
for XRCC3

Medical News
for XRCC3

Publications
for XRCC3

Licensable Technologies
for XRCC3

Services
for XRCC3