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XRCC2 Gene

protein-coding   GIFtS: 61
GCID: GC07M152341

X-Ray Repair Complementing Defective Repair In Chinese Hamster...

  See XRCC2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells
21 2
X-Ray Repair Cross-Complementing Protein 22 3
RAD51-like1
DNA Repair Protein XRCC22

External Ids:    HGNC: 128291   Entrez Gene: 75162   Ensembl: ENSG000001965847   OMIM: 6003755   UniProtKB: O435433   

Export aliases for XRCC2 gene to outside databases

Previous GC identifers: GC07M150590 GC07M151658 GC07M151735 GC07M151781 GC07M151974 GC07M146154


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XRCC2 Gene:
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination
to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand
breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient
mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. (provided by RefSeq, Jul
2008)

GeneCards Summary for XRCC2 Gene:
XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) is a protein-coding gene. Diseases associated with XRCC2 include acoustic neuroma, and neuroma. GO annotations related to this gene include DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair
chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA,
single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

Gene Wiki entry for XRCC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the XRCC2 gene promoter:
         GR   ISGF-3   GATA-3   GR-beta   C/EBPalpha   PPAR-alpha   CREB   HEN1   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): XRCC2 promoter sequence
   Search Chromatin IP Primers for XRCC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XRCC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

XRCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XRCC2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M152341:  view genomic region     (about GC identifiers)

Start:
152,341,864 bp from pter      End:
152,373,250 bp from pter
Size:
31,387 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 151,670,667-151,700,330     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543 (See protein sequence)
Recommended Name: DNA repair protein XRCC2  
Size: 280 amino acids; 31956 Da
Subunit: Interacts with RAD51D. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a
complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. In the absence of DNA, XRCC2-RAD51D formed a
multimeric ring structure. In the presence of single-stranded DNA, XRCC2-RAD51D formed a filamentous structure
Secondary accessions: B2R925

Explore the universe of human proteins at neXtProt for XRCC2: NX_O43543

Explore proteomics data for XRCC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See XRCC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005422.1  
    ENSEMBL proteins: 
     ENSP00000352271  

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    antibodies-online proteins for XRCC2 (4 products) 

     
    antibodies-online peptides for XRCC2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020588 RecA_ATP-bd
     IPR027417 P-loop_NTPase
     IPR013632 DNA_recomb/repair_Rad51_C

    Graphical View of Domain Structure for InterPro Entry O43543

    ProtoNet protein and cluster: O43543

    UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543
    Similarity: Belongs to the RecA family. RAD51 subfamily


    Find genes that share domains with XRCC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XRCC2_HUMAN, O43543
    Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair
    chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA,
    single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

         Genatlas biochemistry entry for XRCC2:
    repair X-ray defect complementing defect in CHO cells,2,promoting the repair of DNA double strand breaks by
    homologous recombination

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000400contributes to four-way junction DNA binding IDA--
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI10749867
    GO:0005524ATP binding IEA--
    GO:0008094DNA-dependent ATPase activity IEA--
         
    Find genes that share ontologies with XRCC2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for XRCC2:
     Increased homologous recombina 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Xrcc2):
     cellular  craniofacial  embryogenesis  growth/size/body  homeostasis/metabolism 
     integument  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     tumorigenesis 

    Find genes that share phenotypes with XRCC2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for XRCC2: Xrcc2tm1Pmc Xrcc2tm1Jtk

       genOway: Develop your customized and physiologically relevant rodent model for XRCC2

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XRCC2_HUMAN, O43543: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005657replication fork IDA--
    GO:0005813centrosome IDA--
    GO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex IDA11751635

    Find genes that share ontologies with XRCC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XRCC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Homologous recombination
    Homologous recombination0.40


    Find genes that share SuperPaths with XRCC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for XRCC2):
        Homologous recombination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including XRCC2: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for XRCC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for XRCC2 (O435431, 2, 3 ENSP000003522714) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD51DO757711, 2, 3, ENSP000003780904EBI-3918457,EBI-1055693 MINT-2730528 MINT-18212 I2D: score=4 STRING: ENSP00000378090
    BLMP541323, ENSP000003472324I2D: score=1 STRING: ENSP00000347232
    RAD51Q066093, ENSP000002678684I2D: score=1 STRING: ENSP00000267868
    RAD51CO435023, ENSP000003367014I2D: score=1 STRING: ENSP00000336701
    RAD51BO153153I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle IMP--
    GO:0000724double-strand break repair via homologous recombination IMP--
    GO:0001701in utero embryonic development IEA--
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair IGI10422536

    Find genes that share ontologies with XRCC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XRCC2

    4 Novoseek inferred chemical compound relationships for XRCC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 53 5 15782136 (1), 17141189 (1)
    camptothecin 32.6 1 12584174 (1)
    caffeine 11 6 11126366 (4)
    cisplatin 0 4 17141189 (3)



    Find genes that share compounds with XRCC2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XRCC2 gene: 
    NM_005431.1  

    Unigene Cluster for XRCC2:

    X-ray repair complementing defective repair in Chinese hamster cells 2
    Hs.647093  [show with all ESTs]
    Unigene Representative Sequence: CR749256
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495707 ENST00000359321(uc003wld.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat XRCC2
      QuantiFast Probe-based Assays in human, mouse, rat XRCC2

    Additional mRNA sequence: 

    AF035587.1 AK313607.1 BC042137.1 CR749256.1 Y08837.1 

    2 DOTS entries:

    DT.91861682  DT.91749840 

    20 AceView cDNA sequences:

    NM_005431 BC042137 BU182381 AF035587 AA978101 BX104116 AI680402 AI346114 
    CR749256 BX283699 BV208285 BE780820 BQ068576 Y08837 BF744461 AW080499 
    BQ430896 AA677337 BG776777 BG494177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XRCC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    XRCC2 Expression
    About this image


    XRCC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Atrioventricular Node
    XRCC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XRCC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647093
        Pathway & Disease-focused RT2 Profiler PCR Arrays including XRCC2: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for XRCC2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xrcc21 , 5 X-ray repair complementing defective repair in Chinese hamster cells 2 less1, 5 79.14(n)1
    78.42(a)1
      5 (12.35 cM)5
    574341  NM_020570.21  NP_065595.21 
     256898125 
    chicken
    (Gallus gallus)
    Aves XRCC21 X-ray repair complementing defective repair in Chinese hamster cells 2 less 73.38(n)
    71.58(a)
      420438  XM_418543.4  XP_418543.3 
    lizard
    (Anolis carolinensis)
    Reptilia XRCC26
    X-ray repair complementing defective repair in Chi...
    61(a)
    1 ↔ 1
    6(4502176-4512089)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia xrcc21 X-ray repair complementing defective repair in Chinese hamster cells 2 less 62.58(n)
    62.45(a)
      100486989  XM_002932495.2  XP_002932541.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5533951 uncharacterized LOC553395 57.67(n)
    52.88(a)
      553395  XM_679999.5  XP_685091.2 


    ENSEMBL Gene Tree for XRCC2 (if available)
    TreeFam Gene Tree for XRCC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for XRCC2 gene
    1 SIMAP similar gene for XRCC2 using alignment to 1 protein entry:     XRCC2_HUMAN:
    DKFZp781P0919

    Find genes that share paralogs with XRCC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for XRCC2 (see all 752)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125403141,2
    A,H--146156354(+) aaaagA/Gaaaaa 1 -- ut31 trp30--------
    rs113033161,2
    C--146161570(+) TTTTT-/TGTAGA 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs350667461,2
    C,F--151678381(+) AAAAA-/A/A   
       A
    /AAA
    GATTC
    2 -- int1 cds12NA 4
    rs590294431,2
    C--151682134(+) TTTTTGTTTTT  
      TTTT
    /-
    TTCTT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs1128547451,2
    C,F--151686756(+) TTTTTG/CAGACG 1 -- int11Minor allele frequency- C:0.50WA 2
    rs666920671,2
    C,F--151689675(-) TGTCT-/A/AAAA
            
    AAAAA
    1 -- int12NA 4
    rs32184391,2
    C,F--151690248(-) AAAAAT/-AGCTG 1 -- int13Minor allele frequency- -:0.04NS NA CSA 170
    rs664624571,2
    C--151691592(-) TTTCTTTT/-TTTTT 2 -- int1 cds12Minor allele frequency- -:0.25NA 4
    rs2007943641,2
    C--151698870(+) ATATT-/ATATAT 1 -- int10--------
    rs107076421,2
    C--152345499(+) AAAAG-/A/A   
       A
    /AAA
    AAAAA
    3 -- ut31 trp30--------

    HapMap Linkage Disequilibrium report for XRCC2 (152341864 - 152373250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for XRCC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1178351CNV Insertion17803354
    esv1318404CNV Insertion17803354
    esv2644156CNV Insertion19546169
    nsv831193CNV Loss17160897
    nsv889505CNV Gain21882294

    Human Gene Mutation Database (HGMD): XRCC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XRCC2
    DNA2.0 Custom Variant and Variant Library Synthesis for XRCC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600375    OMIM disorders: --

    7 diseases for XRCC2:    
    About MalaCards
    acoustic neuroma    neuroma    soft tissue sarcoma    breast disease
    breast-ovarian cancer, familial, 2    breast cancer susceptibility    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for XRCC2:
    Breast cancer

    Find genes that share disorders with XRCC2           About GenesLikeMe

    2 Novoseek inferred disease relationships for XRCC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 30.2 4 15386379 (1), 17141189 (1), 19116388 (1)
    breast cancer 26.7 11 18188695 (3), 12023982 (2), 20004634 (2), 16702393 (1) (see all 6)

    Genetic Association Database (GAD): XRCC2
    Human Genome Epidemiology (HuGE) Navigator: XRCC2 (75 documents)

    Export disorders for XRCC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XRCC2 gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with XRCC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51. (PubMed id 20004634)1, 4, 9 Silva S.N....Gaspar J.F. (Cancer Epidemiol 2010)
    2. Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus. (PubMed id 18188695)1, 4, 9 Loizidou M.A....Hadjisavvas A. (Breast Cancer Res. Treat. 2008)
    3. Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population. (PubMed id 16284386)1, 4, 9 Zhang Z....Xia Z. (amp 2005)
    4. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. (PubMed id 9660962)1, 2, 9 Liu N....Thompson L.H. (Mol. Cell 1998)
    5. XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer. (PubMed id 17986315)1, 4, 9 Jiao L....Li D. (Am. J. Gastroenterol. 2008)
    6. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. (PubMed id 10422536)1, 3, 9 Cui X....Chen D.J. (Mutat. Res. 1999)
    7. [The association of XRCC2 gene polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in China]. (PubMed id 17922422)1, 4, 9 Wang N....Wang S.J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    8. Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PubMed id 12023982)1, 4, 9 Kuschel B....Dunning A. (Hum. Mol. Genet. 2002)
    9. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PubMed id 19116388)1, 4, 9 Vineis P....Matullo G. (J. Natl. Cancer Inst. 2009)
    10. Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan. (PubMed id 18410587)1, 4, 9 Yen C.Y....Chang H.W. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7516 HGNC: 12829 AceView: XRCC2 Ensembl:ENSG00000196584 euGenes: HUgn7516
    ECgene: XRCC2 Kegg: 7516 H-InvDB: XRCC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for XRCC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XRCC2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/xrcc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for XRCC2 gene:
    Search GeneIP for patents involving XRCC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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