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Aliases for XRCC2 Gene

Aliases for XRCC2 Gene

  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 2 2 3 5
  • X-Ray Repair Cross-Complementing Protein 2 4
  • RAD51-Like 2

External Ids for XRCC2 Gene

Previous GeneCards Identifiers for XRCC2 Gene

  • GC07M150590
  • GC07M151658
  • GC07M151735
  • GC07M151781
  • GC07M151974
  • GC07M152341
  • GC07M146154

Summaries for XRCC2 Gene

Entrez Gene Summary for XRCC2 Gene

  • This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]

GeneCards Summary for XRCC2 Gene

XRCC2 (X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 2) is a Protein Coding gene. Diseases associated with XRCC2 include Familial Breast Cancer and Breast Disease. Among its related pathways are Resolution of D-Loop Structures and DNA Double-Strand Break Repair. GO annotations related to this gene include DNA-dependent ATPase activity and four-way junction DNA binding.

UniProtKB/Swiss-Prot for XRCC2 Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Gene Wiki entry for XRCC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC2 Gene

Genomics for XRCC2 Gene

Regulatory Elements for XRCC2 Gene

Enhancers for XRCC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around XRCC2 on UCSC Golden Path with GeneCards custom track

Promoters for XRCC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around XRCC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for XRCC2 Gene

Chromosome:
7
Start:
152,644,779 bp from pter
End:
152,676,165 bp from pter
Size:
31,387 bases
Orientation:
Minus strand

Genomic View for XRCC2 Gene

Genes around XRCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XRCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XRCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRCC2 Gene

Proteins for XRCC2 Gene

  • Protein details for XRCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43543-XRCC2_HUMAN
    Recommended name:
    DNA repair protein XRCC2
    Protein Accession:
    O43543
    Secondary Accessions:
    • B2R925

    Protein attributes for XRCC2 Gene

    Size:
    280 amino acids
    Molecular mass:
    31956 Da
    Quaternary structure:
    • Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA.

neXtProt entry for XRCC2 Gene

Proteomics data for XRCC2 Gene at MOPED

Post-translational modifications for XRCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XRCC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for XRCC2

No data available for DME Specific Peptides for XRCC2 Gene

Domains & Families for XRCC2 Gene

Protein Domains for XRCC2 Gene

Suggested Antigen Peptide Sequences for XRCC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43543

UniProtKB/Swiss-Prot:

XRCC2_HUMAN :
  • Belongs to the RecA family. RAD51 subfamily.
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with XRCC2: view

No data available for Gene Families for XRCC2 Gene

Function for XRCC2 Gene

Molecular function for XRCC2 Gene

GENATLAS Biochemistry:
repair X-ray defect complementing defect in CHO cells,2,promoting the repair of DNA double strand breaks by homologous recombination
UniProtKB/Swiss-Prot Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Gene Ontology (GO) - Molecular Function for XRCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IBA --
GO:0005524 ATP binding IEA --
GO:0008094 DNA-dependent ATPase activity IEA,IBA --
genes like me logo Genes that share ontologies with XRCC2: view
genes like me logo Genes that share phenotypes with XRCC2: view

Human Phenotype Ontology for XRCC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for XRCC2 Gene

MGI Knock Outs for XRCC2:

Animal Model Products

miRNA for XRCC2 Gene

miRTarBase miRNAs that target XRCC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for XRCC2 Gene

Localization for XRCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRCC2 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XRCC2 Gene COMPARTMENTS Subcellular localization image for XRCC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for XRCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with XRCC2: view

Pathways & Interactions for XRCC2 Gene

genes like me logo Genes that share pathways with XRCC2: view

Gene Ontology (GO) - Biological Process for XRCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000731 DNA synthesis involved in DNA repair TAS --
GO:0000732 strand displacement TAS --
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0006312 mitotic recombination IBA --
genes like me logo Genes that share ontologies with XRCC2: view

No data available for SIGNOR curated interactions for XRCC2 Gene

Drugs & Compounds for XRCC2 Gene

(4) Drugs for XRCC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with XRCC2: view

Transcripts for XRCC2 Gene

mRNA/cDNA for XRCC2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XRCC2 Gene

X-ray repair complementing defective repair in Chinese hamster cells 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XRCC2 Gene

No ASD Table

Relevant External Links for XRCC2 Gene

GeneLoc Exon Structure for
XRCC2
ECgene alternative splicing isoforms for
XRCC2

Expression for XRCC2 Gene

mRNA expression in normal human tissues for XRCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XRCC2 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for XRCC2 Gene

This gene is overexpressed in Heart (54.9) and Lung (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for XRCC2 Gene



SOURCE GeneReport for Unigene cluster for XRCC2 Gene Hs.647093

genes like me logo Genes that share expression patterns with XRCC2: view

Protein tissue co-expression partners for XRCC2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for XRCC2 Gene

Orthologs for XRCC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XRCC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XRCC2 35
  • 84.95 (n)
  • 84.23 (a)
XRCC2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XRCC2 35
  • 86.38 (n)
  • 83.15 (a)
XRCC2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xrcc2 35
  • 79.14 (n)
  • 78.42 (a)
Xrcc2 16
Xrcc2 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XRCC2 35
  • 99.64 (n)
  • 99.29 (a)
XRCC2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xrcc2 35
  • 79.62 (n)
  • 79.86 (a)
oppossum
(Monodelphis domestica)
Mammalia XRCC2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XRCC2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves XRCC2 35
  • 73.38 (n)
  • 71.58 (a)
XRCC2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XRCC2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xrcc2 35
  • 62.58 (n)
  • 62.45 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC553395 35
  • 57.67 (n)
  • 52.88 (a)
XRCC2 36
  • 47 (a)
OneToOne
Species with no ortholog for XRCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRCC2 Gene

ENSEMBL:
Gene Tree for XRCC2 (if available)
TreeFam:
Gene Tree for XRCC2 (if available)

Paralogs for XRCC2 Gene

(1) SIMAP similar genes for XRCC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XRCC2: view

No data available for Paralogs for XRCC2 Gene

Variants for XRCC2 Gene

Sequence variations from dbSNP and Humsavar for XRCC2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs4987090 - 152,660,776(-) TCCTT(C/G/T)CCCGA reference, missense
rs3218536 - 152,648,922(-) CTATC(A/G)CCTGG reference, missense
rs3218537 - 152,648,823(-) GGACA(C/T)AGACT reference, missense
rs1029423 -- 152,661,791(-) TCTCA(C/G)TGCTT intron-variant
rs6951085 -- 152,674,538(+) acccg(G/T)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XRCC2 Gene

Variant ID Type Subtype PubMed ID
nsv889505 CNV Gain 21882294
nsv831193 CNV Loss 17160897
esv2644156 CNV Insertion 19546169
esv1178351 CNV Insertion 17803354
esv1318404 CNV Insertion 17803354

Variation tolerance for XRCC2 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XRCC2 Gene

Human Gene Mutation Database (HGMD)
XRCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC2 Gene

Disorders for XRCC2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for XRCC2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
familial breast cancer
  • breast cancer, familial
breast disease
  • breast diseases
lynch syndrome
  • colorectal cancer, hereditary nonpolyposis, type 1
hereditary breast ovarian cancer
  • breast/ovarian cancer, hereditary
dna ligase iv deficiency
  • lig4 syndrome
- elite association - COSMIC cancer census association via MalaCards
Search XRCC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for XRCC2

Genetic Association Database (GAD)
XRCC2
Human Genome Epidemiology (HuGE) Navigator
XRCC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XRCC2
genes like me logo Genes that share disorders with XRCC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XRCC2 Gene

Publications for XRCC2 Gene

  1. Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51. (PMID: 20004634) Silva S.N. … Gaspar J.F. (Cancer Epidemiol 2010) 3 23 48 67
  2. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. (PMID: 10422536) Cui X. … Chen D.J. (Mutat. Res. 1999) 2 3 23
  3. The importance of XRCC2 in RAD51-related DNA damage repair. (PMID: 20189471) Tambini C.E. … Thacker J. (DNA Repair (Amst.) 2010) 3 23
  4. An investigation on the polymorphisms of two DNA repair genes and susceptibility to ESCC and GCA of high-incidence region in northern China. (PMID: 18046624) Wang N. … Li Y. (Mol. Biol. Rep. 2009) 3 23
  5. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PMID: 19116388) Vineis P. … Matullo G. (J. Natl. Cancer Inst. 2009) 3 23

Products for XRCC2 Gene

Sources for XRCC2 Gene

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