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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XRCC2 Gene

protein-coding   GIFtS: 60
GCID: GC07M152341

X-Ray Repair Complementing Defective Repair In Chinese Hamster...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells
21 2
X-Ray Repair Cross-Complementing Protein 22 3
RAD51-like1
DNA Repair Protein XRCC22

External Ids:    HGNC: 128291   Entrez Gene: 75162   Ensembl: ENSG000001965847   OMIM: 6003755   UniProtKB: O435433   

Export aliases for XRCC2 gene to outside databases

Previous GC identifers: GC07M150590 GC07M151658 GC07M151735 GC07M151781 GC07M151974 GC07M146154


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XRCC2 Gene:
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination
to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand
breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient
mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. (provided by RefSeq, Jul
2008)

GeneCards Summary for XRCC2 Gene: 
XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) is a protein-coding gene. Diseases associated with XRCC2 include hereditary breast cancer, and dna ligase iv deficiency, and among its related super-pathways are Homologous recombination. GO annotations related to this gene include DNA-dependent ATPase activity and ATP binding.

UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair
chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA,
single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

Gene Wiki entry for XRCC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XRCC2 gene promoter:
         GR   ISGF-3   GATA-3   GR-beta   C/EBPalpha   PPAR-alpha   CREB   HEN1   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): XRCC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for XRCC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

XRCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XRCC2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M152341:  view genomic region     (about GC identifiers)

Start:
152,341,864 bp from pter      End:
152,373,250 bp from pter
Size:
31,387 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 151,670,667-151,700,330     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543 (See protein sequence)
Recommended Name: DNA repair protein XRCC2  
Size: 280 amino acids; 31956 Da
Subunit: Interacts with RAD51D. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a
complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. In the absence of DNA, XRCC2-RAD51D formed a
multimeric ring structure. In the presence of single-stranded DNA, XRCC2-RAD51D formed a filamentous structure
Subcellular location: Nucleus
Secondary accessions: B2R925

Explore the universe of human proteins at neXtProt for XRCC2: NX_O43543

Explore proteomics data for XRCC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43543

  • XRCC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    XRCC2 Protein Expression
    REFSEQ proteins: NP_005422.1  
    ENSEMBL proteins: 
     ENSP00000352271  

    Human Recombinant Protein Products for XRCC2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for XRCC2
    OriGene Protein Over-expression Lysate for XRCC2
    OriGene MassSpec for XRCC2 
    OriGene Custom Protein Services for XRCC2
    GenScript Custom Purified and Recombinant Proteins Services for XRCC2
    Novus Biologicals XRCC2 Protein
    Novus Biologicals XRCC2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XRCC2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    XRCC2 for ontologies           About GeneDecksing



    XRCC2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of XRCC2
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    Novus Biologicals XRCC2 Antibodies
    Abcam antibodies for XRCC2
    Cloud-Clone Corp. Antibodies for XRCC2 
    ThermoFisher Antibodies for XRCC2
    LSBio Antibodies in human, mouse, rat for XRCC2 

    Assay Products for XRCC2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for XRCC2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for XRCC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for XRCC2 
    Cloud-Clone Corp. CLIAs for XRCC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR020588 DNA_recomb_RecA/RadB_ATP-bd
     IPR027417 P-loop_NTPase
     IPR013632 DNA_recomb/repair_Rad51_C

    Graphical View of Domain Structure for InterPro Entry O43543

    ProtoNet protein and cluster: O43543

    UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543
    Similarity: Belongs to the RecA family. RAD51 subfamily


    XRCC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XRCC2_HUMAN, O43543
    Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair
    chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA,
    single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

         Genatlas biochemistry entry for XRCC2:
    repair X-ray defect complementing defect in CHO cells,2,promoting the repair of DNA double strand breaks by
    homologous recombination

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI10749867
    GO:0005524ATP binding IEA--
    GO:0008094DNA-dependent ATPase activity IEA--
         
    XRCC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for XRCC2:
     Increased homologous recombina 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Xrcc2):
     cellular  craniofacial  embryogenesis  growth/size  homeostasis/metabolism 
     integument  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     tumorigenesis 

    XRCC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for XRCC2: Xrcc2tm1Pmc Xrcc2tm1Jtk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for XRCC2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XRCC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XRCC2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XRCC2 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate XRCC2
    SwitchGear 3'UTR luciferase reporter plasmidXRCC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for XRCC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRCC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for XRCC2
    Sirion Biotech Customized adenovirus for overexpression of XRCC2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for XRCC2 (see all 7)
    OriGene ORF clones in mouse, rat for XRCC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: XRCC2 (NM_005431)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XRCC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC2
    Sirion Biotech Customized lentivirus for stable overexpression of XRCC2 
                         Customized lentivirus expression plasmids for stable overexpression of XRCC2 

    Cell Line
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    Search LifeMap BioReagents cell lines for XRCC2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for XRCC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Homologous recombination
    Homologous recombination0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for XRCC2):
        Homologous recombination


    XRCC2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XRCC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for XRCC2 (O435432, 3 ENSP000003522714) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD51DO757712, 3, ENSP000003780904MINT-2730528 MINT-18212 I2D: score=4 STRING: ENSP00000378090
    BLMP541323, ENSP000003472324I2D: score=1 STRING: ENSP00000347232
    RAD51Q066093, ENSP000002678684I2D: score=1 STRING: ENSP00000267868
    RAD51CO435023, ENSP000003367014I2D: score=1 STRING: ENSP00000336701
    RAD51BO153153I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair IGI10422536
    GO:0006974response to DNA damage stimulus ----

    XRCC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    XRCC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XRCC2

    4 Novoseek inferred chemical compound relationships for XRCC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 53 5 15782136 (1), 17141189 (1)
    camptothecin 32.6 1 12584174 (1)
    caffeine 11 6 11126366 (4)
    cisplatin 0 4 17141189 (3)

    Search CenterWatch for drugs/clinical trials and news about XRCC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for XRCC2 gene: 
    NM_005431.1  

    Unigene Cluster for XRCC2:

    X-ray repair complementing defective repair in Chinese hamster cells 2
    Hs.647093  [show with all ESTs]
    Unigene Representative Sequence: CR749256
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495707 ENST00000359321(uc003wld.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XRCC2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate XRCC2
    SwitchGear 3'UTR luciferase reporter plasmidXRCC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for XRCC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XRCC2
    Clone
    Products:
         
    OriGene clones in human, mouse for XRCC2 (see all 7)
    OriGene ORF clones in mouse, rat for XRCC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: XRCC2 (NM_005431)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XRCC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC2
    Sirion Biotech Customized lentivirus for stable overexpression of XRCC2 
                         Customized lentivirus expression plasmids for stable overexpression of XRCC2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for XRCC2
    OriGene qSTAR qPCR primer pairs in human, mouse for XRCC2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XRCC2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC2

    Additional mRNA sequence: 

    AF035587.1 AK313607.1 BC042137.1 CR749256.1 Y08837.1 

    2 DOTS entries:

    DT.91861682  DT.91749840 

    20 AceView cDNA sequences:

    BC042137 BU182381 NM_005431 AF035587 BE780820 BV208285 BQ068576 BX104116 
    Y08837 AI346114 AI680402 CR749256 AA978101 BX283699 BF744461 BQ430896 
    AA677337 AW080499 BG776777 BG494177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XRCC2 expression in normal human tissues (normalized intensities)      XRCC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    XRCC2 Expression
    About this image


    XRCC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node

    See XRCC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XRCC2

    SOURCE GeneReport for Unigene cluster: Hs.647093
        SABiosciences Expression via Pathway-Focused PCR Arrays including XRCC2: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for XRCC2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xrcc21 , 5 X-ray repair complementing defective repair in Chinese more1, 5 79.14(n)1
    78.42(a)1
      5 (12.35 cM)5
    574341  NM_020570.21  NP_065595.21 
     256898125 
    chicken
    (Gallus gallus)
    Aves XRCC21 X-ray repair complementing defective repair in Chinese more 73.38(n)
    71.58(a)
      420438  XM_418543.3  XP_418543.3 
    lizard
    (Anolis carolinensis)
    Reptilia XRCC26
    X-ray repair complementing defective repair in Chi...
    61(a)
    1 ↔ 1
    6(4502176-4512089)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5533951 uncharacterized LOC553395 57.67(n)
    52.88(a)
      553395  XM_679999.4  XP_685091.2 


    ENSEMBL Gene Tree for XRCC2 (if available)
    TreeFam Gene Tree for XRCC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for XRCC2 gene
    1 SIMAP similar gene for XRCC2 using alignment to 1 protein entry:     XRCC2_HUMAN:
    DKFZp781P0919

    XRCC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/752 SNPs in XRCC2 are shown (see all 752)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125403141,2
    A,H--146156354(+) aaaagA/Gaaaaa 1 -- ut31 trp30--------
    rs113033161,2
    C--146161570(+) TTTTT-/TGTAGA 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs350667461,2
    C,F--151678381(+) AAAAA-/A/A   
       A
    /AAA
    GATTC
    2 -- int1 cds12NA 4
    rs590294431,2
    C--151682134(+) TTTTTGTTTTT  
      TTTT
    /-
    TTCTT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs1128547451,2
    C,F--151686756(+) TTTTTG/CAGACG 1 -- int11Minor allele frequency- C:0.50WA 2
    rs666920671,2
    C,F--151689675(-) TGTCT-/A/AAAA
            
    AAAAA
    1 -- int12NA 4
    rs32184391,2
    C,F--151690248(-) AAAAAT/-AGCTG 1 -- int13Minor allele frequency- -:0.04NS NA CSA 170
    rs664624571,2
    C--151691592(-) TTTCTTTT/-TTTTT 2 -- int1 cds12Minor allele frequency- -:0.25NA 4
    rs2007943641,2
    C--151698870(+) ATATT-/ATATAT 1 -- int10--------
    rs107076421,2
    C--152345499(+) AAAAG-/A/A   
       A
    /AAA
    AAAAA
    3 -- ut31 trp30--------

    HapMap Linkage Disequilibrium report for XRCC2 (152341864 - 152373250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for XRCC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1178351CNV Insertion17803354
    esv1318404CNV Insertion17803354
    esv2644156CNV Insertion19546169
    nsv831193CNV Loss17160897
    nsv889505CNV Gain21882294


    Human Gene Mutation Database (HGMD): XRCC2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing XRCC2
    DNA2.0 Custom Variant and Variant Library Synthesis for XRCC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600375    OMIM disorders: --

    20/39 diseases for XRCC2 (see all 39):    About MalaCards
    hereditary breast cancer    dna ligase iv deficiency    acoustic neuroma    neuroma
    soft tissue sarcoma    breast cancer susceptibility    t cell deficiency    bloom syndrome
    breast disease    follicular lymphoma    lynch syndrome    skin cancer
    diffuse large b-cell lymphoma    esophageal adenocarcinoma    b-cell lymphomas    ovarian cancer
    oral cancer    thyroid cancer    esophageal squamous cell carcinoma    acute myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for XRCC2:
    Breast cancer

    XRCC2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for XRCC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 30.2 4 15386379 (1), 17141189 (1), 19116388 (1)
    breast cancer 26.7 11 18188695 (3), 12023982 (2), 20004634 (2), 16702393 (1) (see all 6)

    Genetic Association Database (GAD): XRCC2
    Human Genome Epidemiology (HuGE) Navigator: XRCC2 (75 documents)

    Export disorders for XRCC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XRCC2 gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with XRCC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Breast cancer risk and common single nucleotide polym orphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS 1 and RAD51. (PubMed id 20004634)1, 4, 9 Silva S.N....Gaspar J.F. (2010)
    2. Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus. (PubMed id 18188695)1, 4, 9 Loizidou M.A....Hadjisavvas A. (2008)
    3. Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population. (PubMed id 16284386)1, 4, 9 Zhang Z....Xia Z. (2005)
    4. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. (PubMed id 9660962)1, 2, 9 Liu N....Thompson L.H. (1998)
    5. XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer. (PubMed id 17986315)1, 4, 9 Jiao L....Li D. (2008)
    6. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. (PubMed id 10422536)1, 3, 9 Cui X....Chen D.J. (1999)
    7. [The association of XRCC2 gene polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in China] (PubMed id 17922422)1, 4, 9 Wang N....Wang S.J. (2007)
    8. Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PubMed id 12023982)1, 4, 9 Kuschel B....Dunning A. (2002)
    9. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PubMed id 19116388)1, 4, 9 Vineis P....Matullo G. (2009)
    10. Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan. (PubMed id 18410587)1, 4, 9 Yen C.Y....Chang H.W. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7516 HGNC: 12829 AceView: XRCC2 Ensembl:ENSG00000196584 euGenes: HUgn7516
    ECgene: XRCC2 Kegg: 7516 H-InvDB: XRCC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XRCC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XRCC2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/xrcc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for XRCC2 gene:
    Search GeneIP for patents involving XRCC2

    GeneCards and IP:
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