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Aliases & Descriptions for XRCC2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp781P0919 2 | | RAD51-like 2 |
| | | Descriptions |
|---|
| DNA repair protein XRCC2 2 | X-ray repair complementing defective repair in Chinese hamster cells 2 2 | | X-ray repair cross complementing protein 2 2 | | X-ray repair cross-complementing protein 2 3 | X-ray repair, complementing defective, repair in Chinese hamster 2 |
|
| | Search outside databases for aliases for XRCC2 genePrevious GC identifers: GC07M150590 GC07M151658 GC07M151735 GC07M151781 |
Summaries for XRCC2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for XRCC2: This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq] UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNAGene Wiki entry for XRCC2 |
Genomic Location for XRCC2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the XRCC2 gene 
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36XRCC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M151974:
(about GC identifiers)
Start:
|
151,974,516 bp from pter |
End:
|
152,004,183 bp from pter |
Size:
|
29,668 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 151,670,667-151,700,330 |
RefSeq DNA sequence:- NC_000007.12 NT_007914.14 NT_079596.2
| Proteins for XRCC2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543 (See
protein sequence)Recommended Name: DNA repair protein XRCC2 Size: 280 amino acids; 31956 Da
Subunit: Interacts with RAD51D. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. In the absence of DNA, XRCC2-RAD51D formed a multimeric ring structure. In the presence of single-stranded DNA, XRCC2-RAD51D formed a filamentous structure
Subcellular location: NucleusPost-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005422.1
ENSEMBL proteins: ENSP00000352271
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for XRCC2: Assays for XRCC2: | Protein
Domains/ Families for XRCC2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43543
ProtoNet protein and cluster: O43543 UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543Similarity: Belongs to the recA family. RAD51 subfamily | Gene Function for XRCC2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005431
Applied Biosystems Silencer® siRNAs for XRCC2
Sigma-Aldrich siRNA and siRNA Panels for XRCC2  Sigma-Aldrich shRNA Panels and shRNA for XRCC2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005431                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005431                                  untagged cDNA clone in CMV expression vector: NM_005431 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005431
UniProtKB/Swiss-Prot: XRCC2_HUMAN, O43543Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNAGenatlas biochemistry entry for XRCC2:repair X-ray defect complementing defect in CHO cells,2,promoting the repair of DNA double strand breaks by homologous recombination12 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Xrcc2):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for XRCC2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for XRCC2 
5/19 Interacting proteins for XRCC2 (ENSP000003522713 O435432) via UniProtKB, MINT, and/or STRING (see all 19
)About this table
5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10
): About this table
|
Drugs & Compounds for XRCC2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for XRCC2
|
Transcripts for XRCC2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005431
Sigma-Aldrich siRNA and siRNA Panels for XRCC2  Sigma-Aldrich shRNA Panels and shRNA for XRCC2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005431 REFSEQ mRNAs for XRCC2 gene: NM_005431.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005431               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005431                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005431                                  untagged cDNA clone in CMV expression vector: NM_005431  Additional cDNA sequence: AF035587.1 AK313607.1 BC042137.1 CR749256.1 Y08837.1 2 DOTS entries: DT.91861682 DT.91749840 20 AceView cDNA sequences:NM_005431 BU182381 BC042137 AF035587 BQ068576 BV208285 AA978101 BE780820 BX283699 AI680402 Y08837 BX104116 CR749256 AI346114 BF744461 AA677337 BQ430896 AW080499 BG776777 BG494177
highest scoring ESTs for XRCC2:Y08837 AF035587 BC042137 BQ068576 BX283699 CN290945 CN290947 NM_005431 AA255634 AI346114 Unigene Cluster for XRCC2: X-ray repair complementing defective repair in Chinese hamster cells 2 Hs.647093 [show with all ESTs]Unigene Representative Sequence: CR749256
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000359321
|
Expression for XRCC2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| XRCC2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for XRCC2
1 / 2 / 3 4 probe-sets matching XRCC2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.647093
Expression variation in blood from EXPOLDB for XRCC2 |
Orthologs for XRCC2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XRCC2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for XRCC2
ENSEMBL Gene Tree for XRCC2 | Paralogs for XRCC2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for XRCC2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for XRCC2 (up to first 250kb)
|
Disorders & Mutations for XRCC2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600375
2 Novoseek disease relationships for XRCC2 gene
About this table
Human Gene Mutation Database: XRCC2 Genetic Association Database: XRCC2 Human Genome Epidemiology Navigator: XRCC2 (50 documents)
|
Medical News for XRCC2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for XRCC2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/105 PubMed articles for XRCC2 gene (see all 105
):- Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population. (PubMed id 16284386)1, 3, 6 Zhang Z....Xia Z. (2005)
- XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. (PubMed id 9660962)1, 3, 4 Liu N....Thompson L.H. (1998)
- The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. (PubMed id 10422536)1, 2, 3 Cui X....Chen D.J. (1999)
- Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PubMed id 12023982)1, 3, 6 Kuschel B....Dunning A. (2002)
- Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)1, 3, 6 Zienolddiny S....Haugen A. (2006)
- Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PubMed id 11842112)1, 3, 4 Wiese C....Schild D. (2002)
- The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. (PubMed id 9628903)1, 3, 4 Cartwright R.... Thacker J. (1998)
- Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk. (PubMed id 15066914)1, 3, 6 Han J....Hunter D.J. (2004)
- DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. (PubMed id 15386379)1, 3, 6 Benhamou S....Hirvonen A. (2004)
- RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PubMed id 11744692)1, 3, 4 Miller K.A....Albala J.S. (2002)
|
Search for XRCC2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing XRCC2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing XRCC2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XRCC2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for XRCC2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for XRCC2:

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