Aliases for XRCC1 Gene
Aliases for XRCC1 Gene
External Ids for XRCC1 Gene
- HGNC: 12828
- Entrez Gene: 7515
- Ensembl: ENSG00000073050
- OMIM: 194360
- UniProtKB: P18887
Previous HGNC Symbols for XRCC1 Gene
- RCC
Previous GeneCards Identifiers for XRCC1 Gene
- GC19M044692
- GC19M044439
- GC19M048723
- GC19M048739
- GC19M044047
- GC19M040478
Summaries for XRCC1 Gene
-
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
GeneCards Summary for XRCC1 Gene
XRCC1 (X-Ray Repair Cross Complementing 1) is a Protein Coding gene. Diseases associated with XRCC1 include Gastric Cardia Carcinoma and Xeroderma Pigmentosum, Group D. Among its related pathways are DNA Double-Strand Break Repair and FOXM1 transcription factor network. GO annotations related to this gene include enzyme binding and damaged DNA binding. An important paralog of this gene is ENSG00000268361.
UniProtKB/Swiss-Prot for XRCC1 Gene
-
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC1 Gene
Genomics for XRCC1 Gene
Regulatory Elements for XRCC1 Gene
Enhancers for XRCC1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around XRCC1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the XRCC1 gene promoter:
Regulatory Element Products
Genomic Location for XRCC1 Gene
- Chromosome:
- 19
- Start:
- 43,543,040 bp from pter
- End:
- 43,580,473 bp from pter
- Size:
- 37,434 bases
- Orientation:
- Minus strand
Genomic View for XRCC1 Gene
Genes around XRCC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.31 by Ensembl
- 19q13.31 by Entrez Gene
- 19q13.2 by HGNC
XRCC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XRCC1 Gene
Proteins for XRCC1 Gene
-
Protein details for XRCC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18887-XRCC1_HUMAN
- Recommended name:
- DNA repair protein XRCC1
- Protein Accession:
- P18887
- Q6IBS4
- Q9HCB1
Protein attributes for XRCC1 Gene
- Size:
- 633 amino acids
- Molecular mass:
- 69477 Da
- Quaternary structure:
-
- Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.
Protein Expression for XRCC1 Gene
Post-translational modifications for XRCC1 Gene
- Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
- Sumoylated.
- Glycosylation at Thr296
- Modification sites at PhosphoSitePlus
Other Protein References for XRCC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for XRCC1 (XRCC1)
-
Custom Antibody ServicesOriGene Antibodies for XRCC1
- AM05323PU-N
- AP06480PU-N
- TA500886AM
- TA500886BM
- TA500886CM
- TA500886DM
- TA500886EM
- TA500886FM
- TA500886GM
- TA500886HM
- TA500886JM
- TA500886S
- TA312309
- TA324813
- TA330899
- TA347071
- TA347508
- TA500847
- CF500847
- TA500879
- CF500879
- TA500880
- CF500880
- TA500881
- CF500881
- TA500886
- CF500886
- TA500889
- CF500889
- TA590221
- UM500037
- UM570037
- Novus Biologicals Antibodies for XRCC1
- Invitrogen Antibodies for XRCC1
- antibodies-online Antibodies for XRCC1: See all 126
- GeneTex XRCC1 antibody for XRCC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for XRCC1
Protein Products
-
OriGene Purified Proteins for XRCC1
- Search Origene for MassSpec and Protein Over-expression Lysates for XRCC1
- Origene Custom Protein Services for XRCC1
- antibodies-online Proteins for XRCC1: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for XRCC1
Assay Products
- antibodies-online Kits for XRCC1: See all 3
No data available for DME Specific Peptides for XRCC1 Gene
Domains & Families for XRCC1 Gene
Protein Domains for XRCC1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for XRCC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for XRCC1 Gene
Function for XRCC1 Gene
Molecular function for XRCC1 Gene
- GENATLAS Biochemistry:
- repair X-ray defect,complementing defect in CHO cells,1,involved in single-strand DNA break rejoining,susceptibility gene for squamous cell carcinoma of the head and neck
- UniProtKB/Swiss-Prot Function:
- Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003684 | damaged DNA binding | IEA | -- |
| GO:0003909 | DNA ligase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 14755728 |
| GO:0019899 | enzyme binding | IPI | 8532526 |
| GO:1990599 | 3 overhang single-stranded DNA endodeoxyribonuclease activity | IEA | -- |
Phenotypes for XRCC1 Gene
- MGI mutant phenotypes for XRCC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for XRCC1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Synthetic lethal with Ras
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
Animal Models for XRCC1 Gene
- MGI Knock Outs for XRCC1:
-
- Xrcc1 tm1Rpe
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for XRCC1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for XRCC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
- Search ViGene Biosciences for XRCC1
CRISPR Products
-
OriGene CRISPR knockouts for XRCC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for XRCC1
- GenScript: Design CRISPR guide RNA sequences for XRCC1
miRNA for XRCC1 Gene
- miRTarBase miRNAs that target XRCC1
miRNA Products
- Search ViGene Biosciences for XRCC1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for XRCC1
- Browse OriGene Inhibitory RNA Products For XRCC1
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for XRCC1
- VectorBuilder custom plasmid, inducible vectors for XRCC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XRCC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for XRCC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XRCC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XRCC1 Gene
Localization for XRCC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for XRCC1 Gene
- Nucleus. Note=Accumulates at sites of DNA damage.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | nuclear chromosome, telomeric region | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0070522 | ERCC4-ERCC1 complex | IEA | -- |
Pathways & Interactions for XRCC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Telomere C-strand (Lagging Strand) Synthesis | ||
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 4 | DNA Damage | ||
| 5 | Chks in Checkpoint Regulation | ||
Pathways by source for XRCC1 Gene
1 Cell Signaling Technology pathway for XRCC1 Gene
2 BioSystems pathways for XRCC1 Gene
1 KEGG pathway for XRCC1 Gene
1 Qiagen pathway for XRCC1 Gene
Interacting Proteins for XRCC1 Gene
Selected Interacting proteins:
ENSP00000262887
P18887-XRCC1_HUMAN
for XRCC1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000012 | single strand break repair | IEA | -- |
| GO:0000724 | double-strand break repair via homologous recombination | TAS | -- |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
Drugs & Compounds for XRCC1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 | 2770 | ||
| Oxaliplatin | Approved, Investigational | Pharma | Antitumor agent, Platinum | 1460 | ||
| Carboplatin | Approved | Pharma | Antitumor agent that forms platinum-DNA adducts., Platinum | 2050 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 2935 | ||
| Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 1856 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for XRCC1 Gene
mRNA/cDNA for XRCC1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (374) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XRCC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XRCC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for XRCC1
- GenScript: Design CRISPR guide RNA sequences for XRCC1
miRNA Products
- Search ViGene Biosciences for XRCC1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for XRCC1
- Browse OriGene Inhibitory RNA Products For XRCC1
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for XRCC1
- VectorBuilder custom plasmid, inducible vectors for XRCC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XRCC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for XRCC1 Gene
This gene is overexpressed in Lymph node (7.0) and Gallbladder (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XRCC1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of XRCC1 Gene:
XRCC1SOURCE GeneReport for Unigene cluster for XRCC1 Gene:
Hs.98493Evidence on tissue expression from TISSUES for XRCC1 Gene
- Eye(4.3)
- Liver(4.3)
- Nervous system(3.5)
- Blood(2.8)
- Lung(2.3)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for XRCC1
-
OriGene qPCR primer pairs for XRCC1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XRCC1 Gene
Orthologs for XRCC1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | XRCC1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | XRCC1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | XRCC1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Xrcc1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Xrcc1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | xrcc1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | xrcc1-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | xrcc1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | XRCC1 36 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for XRCC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for XRCC1 Gene
Paralogs for XRCC1 Gene
Variants for XRCC1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC1 Gene
- XRCC1_HUMAN-P18887
- Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs25487 | drug-response | 43,551,574(-) | CTCCC(A/G)GAGGT | reference, missense | |
| VAR_036277 | A colorectal cancer sample | ||||
| rs1000096322 | -- | 43,568,461(+) | TACTA(C/T)ACTCC | intron-variant | |
| rs1000196241 | -- | 43,559,377(+) | ACTCC(A/G)GAGGC | intron-variant | |
| rs1000311454 | -- | 43,562,064(+) | TCTCT(G/T)GAACC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3603n100 | CNV | gain | 25217958 |
| nsv1056785 | CNV | gain | 25217958 |
| nsv1057657 | CNV | gain | 25217958 |
| nsv1063149 | CNV | gain | 25217958 |
| nsv1123259 | CNV | deletion | 24896259 |
| nsv1134793 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.78;
83.33% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for XRCC1 Gene
Disorders for XRCC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric cardia carcinoma |
|
|
| xeroderma pigmentosum, group d |
|
|
| fibrosclerosis of breast |
|
|
| non-proliferative fibrocystic change of the breast |
|
|
| mutagen sensitivity |
|
|
Search XRCC1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for XRCC1
No data available for UniProtKB/Swiss-Prot and Genatlas for XRCC1 Gene
Publications for XRCC1 Gene
- The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. (PMID: 11782372) Nelson H.H. … Karagas M.R. (Cancer Res. 2002) 3 4 22 46 64
- The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens. (PMID: 19908066) Artac M. … Savas B. (J. Cancer Res. Clin. Oncol. 2010) 3 22 46 64
- DNA repair gene X-ray repair cross-complementing group 1 and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer: a study from North India. (PMID: 20070155) Mandal R.K. … Mittal R.D. (DNA Cell Biol. 2010) 3 22 46 64
- Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women. (PMID: 20140625) Sterpone S. … Cozzi R. (J. Cancer Res. Clin. Oncol. 2010) 3 22 46 64
- Pterygium and genetic polymorphisms of the DNA repair enzymes XRCC1, XPA, and XPD. (PMID: 20431719) Chiang C.C. … Tsai F.J. (Mol. Vis. 2010) 3 22 46 64
Products for XRCC1 Gene
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- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for XRCC1
- AM05323PU-N
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- TA500886GM
- TA500886HM
- TA500886JM
- TA500886S
- TA312309
- TA324813
- TA330899
- TA347071
- TA347508
- TA500847
- CF500847
- TA500879
- CF500879
- TA500880
- CF500880
- TA500881
- CF500881
- TA500886
- CF500886
- TA500889
- CF500889
- TA590221
- UM500037
- UM570037
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for XRCC1
- Novus Biologicals proteins and lysates for XRCC1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for XRCC1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for XRCC1
- antibodies-online Antibodies for XRCC1: See all 126
- antibodies-online Kits for XRCC1: See all 3
- antibodies-online Proteins for XRCC1: See all 8
- Search antibodies-online for peptides
- GeneTex XRCC1 antibody for XRCC1
- Search GeneTex for Proteins for XRCC1
- ViGene Biosciences adenoviral particle packaged cDNA for XRCC1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XRCC1 gene
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- Search ViGene Biosciences for XRCC1
- Santa Cruz Biotechnology (SCBT) Antibodies for XRCC1
- Search Santa Cruz Biotechnology (SCBT) for XRCC1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for XRCC1
- Cyagen custom Knockout/knockin (KOKI) mouse models for XRCC1
- VectorBuilder custom plasmid, inducible vectors for XRCC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XRCC1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for XRCC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
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