Aliases for XRCC1 Gene
Aliases for XRCC1 Gene
External Ids for XRCC1 Gene
- HGNC: 12828
- Entrez Gene: 7515
- Ensembl: ENSG00000073050
- OMIM: 194360
- UniProtKB: P18887
Previous HGNC Symbols for XRCC1 Gene
- RCC
Previous GeneCards Identifiers for XRCC1 Gene
- GC19M044692
- GC19M044439
- GC19M048723
- GC19M048739
- GC19M044047
- GC19M040478
Summaries for XRCC1 Gene
-
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
GeneCards Summary for XRCC1 Gene
XRCC1 (X-Ray Repair Cross Complementing 1) is a Protein Coding gene. Diseases associated with XRCC1 include Spinocerebellar Ataxia, Autosomal Recessive 26 and Gastric Cardia Carcinoma. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include enzyme binding and damaged DNA binding. An important paralog of this gene is ENSG00000268361.
UniProtKB/Swiss-Prot for XRCC1 Gene
-
Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.
Additional gene information for XRCC1 Gene
- Monarch Initiative
- Search for XRCC1 at DataMed
- Search for XRCC1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC1 Gene
Genomics for XRCC1 Gene
GeneHancer (GH) Regulatory Elements for XRCC1 Gene
Regulatory Element Products
Genomic Locations for XRCC1 Gene
- chr19:43,543,040-43,580,473
- (GRCh38/hg38)
- Size:
- 37,434 bases
- Orientation:
- Minus strand
- chr19:44,047,192-44,084,625
- (GRCh37/hg19)
Genomic View for XRCC1 Gene
- Cytogenetic band:
-
- 19q13.31 by Ensembl
- 19q13.31 by Entrez Gene
- 19q13.2 by HGNC


RefSeq DNA sequence for XRCC1 Gene
Proteins for XRCC1 Gene
-
Protein details for XRCC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18887-XRCC1_HUMAN
- Recommended name:
- DNA repair protein XRCC1
- Protein Accession:
- P18887
- Q6IBS4
- Q9HCB1
Protein attributes for XRCC1 Gene
- Size:
- 633 amino acids
- Molecular mass:
- 69477 Da
- Quaternary structure:
-
- Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.
Protein Expression for XRCC1 Gene
Post-translational modifications for XRCC1 Gene
- Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
- Sumoylated.
- Glycosylation at isoforms=296
Other Protein References for XRCC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for XRCC1 (XRCC1)
- Novus Biologicals Antibodies for XRCC1
-
Abcam antibodies for XRCC1
- Invitrogen Antibodies for XRCC1
- antibodies-online: Search results for 126 available XRCC1 Antibodies ranked by validation data
- Compare Top XRCC1 Antibodies
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Recommended
- 1 IHC (p) Antibody (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 26 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 19 WB Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-human)
- 3 IP Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 103 WB Antibodies (anti-human)
- GeneTex XRCC1 antibody for XRCC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for XRCC1
Protein Products
-
OriGene Purified Proteins for XRCC1
- Search Origene for MassSpec and Protein Over-expression Lysates for XRCC1
- Origene Custom Protein Services for XRCC1
- Search GeneTex for Proteins for XRCC1
-
Abcam proteins for XRCC1
Assay Products
No data available for DME Specific Peptides for XRCC1 Gene
Domains & Families for XRCC1 Gene
Gene Families for XRCC1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for XRCC1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for XRCC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for XRCC1 Gene
Function for XRCC1 Gene
Molecular function for XRCC1 Gene
- GENATLAS Biochemistry:
- repair X-ray defect,complementing defect in CHO cells,1,involved in single-strand DNA break rejoining,susceptibility gene for squamous cell carcinoma of the head and neck
- UniProtKB/Swiss-Prot Function:
- Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.
Phenotypes From GWAS Catalog for XRCC1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003684 | damaged DNA binding | IEA | -- |
GO:0003909 | DNA ligase activity | TAS | -- |
GO:0005515 | protein binding | IPI | 14755728 |
GO:0019899 | enzyme binding | IPI | 8532526 |
GO:0032356 | oxidized DNA binding | IMP | 28002403 |
Phenotypes for XRCC1 Gene
- MGI mutant phenotypes for XRCC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for XRCC1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Synthetic lethal with Ras
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
Animal Models for XRCC1 Gene
- MGI Knock Outs for XRCC1:
-
- Xrcc1 tm1Rpe
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for XRCC1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for XRCC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
- Search ViGene Biosciences for XRCC1
CRISPR Products
-
OriGene CRISPR knockouts for XRCC1
- genomics-online: gRNA clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
- Applied Biological Materials CRISPR for XRCC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for XRCC1
- GenScript: Design CRISPR guide RNA sequences for XRCC1
miRNA for XRCC1 Gene
- miRTarBase miRNAs that target XRCC1
miRNA Products
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Inhibitory RNA Products
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- Overview of 93 available XRCC1 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XRCC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XRCC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for XRCC1
- Applied Biological Materials Clones for XRCC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for XRCC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XRCC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XRCC1 Gene
Localization for XRCC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for XRCC1 Gene
- Nucleus. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage. {ECO:0000269 PubMed:28002403}.
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000784 | nuclear chromosome, telomeric region | IEA | -- |
GO:0000790 | nuclear chromatin | IDA | 28002403 |
GO:0005634 | nucleus | IEA,IDA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IDA | 28002403 |
Pathways & Interactions for XRCC1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Telomere C-strand (Lagging Strand) Synthesis | ||
2 | DNA Double-Strand Break Repair |
.53
|
|
3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
4 | DNA Damage | ||
5 | Chks in Checkpoint Regulation |
Pathways by source for XRCC1 Gene
1 Cell Signaling Technology pathway for XRCC1 Gene
2 BioSystems pathways for XRCC1 Gene
1 KEGG pathway for XRCC1 Gene
1 Qiagen pathway for XRCC1 Gene
Interacting Proteins for XRCC1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000012 | single strand break repair | IEA | -- |
GO:0000724 | double-strand break repair via homologous recombination | TAS | -- |
GO:0001666 | response to hypoxia | IEA | -- |
GO:0006281 | DNA repair | IEA | -- |
GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
Drugs & Compounds for XRCC1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 2906 | ||
Oxaliplatin | Approved, Investigational | Pharma | Antitumor agent, Platinum | 1560 | ||
Carboplatin | Approved | Pharma | Antitumor agent that forms platinum-DNA adducts., Platinum | 2141 | ||
Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3113 | ||
Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 1970 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for XRCC1 Gene
mRNA/cDNA for XRCC1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (374) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XRCC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XRCC1
- genomics-online: gRNA clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
- Applied Biological Materials CRISPR for XRCC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for XRCC1
- GenScript: Design CRISPR guide RNA sequences for XRCC1
miRNA Products
- Search ViGene Biosciences for XRCC1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for XRCC1
- Browse OriGene Inhibitory RNA Products For XRCC1
- genomics-online: shRNA clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XRCC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XRCC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for XRCC1
- Applied Biological Materials Clones for XRCC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: |
Expression for XRCC1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XRCC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of XRCC1 Gene:
XRCC1SOURCE GeneReport for Unigene cluster for XRCC1 Gene:
Hs.98493mRNA Expression by UniProt/SwissProt for XRCC1 Gene:
P18887-XRCC1_HUMANEvidence on tissue expression from TISSUES for XRCC1 Gene
- Eye(4.3)
- Liver(4.3)
- Nervous system(3.5)
- Blood(2.8)
- Lung(2.3)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for XRCC1
-
OriGene qPCR primer pairs and template standards for XRCC1
- genomics-online: primer clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XRCC1 Gene
Orthologs for XRCC1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | XRCC1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | XRCC1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | XRCC1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Xrcc1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Xrcc1 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | xrcc1 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | xrcc1-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | xrcc1 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | XRCC1 35 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for XRCC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for XRCC1 Gene
Paralogs for XRCC1 Gene
Variants for XRCC1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC1 Gene
- XRCC1_HUMAN-P18887
- Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1799782 | not-provided, Non-small cell lung cancer | 43,553,422(-) | G/A | coding_sequence_variant, missense_variant | |
rs25487 | drug-response, carboplatin response - Efficacy, Toxicity/ADR, platinum response - Efficacy, Toxicity/ADR, Platinum compounds response - Efficacy, Toxicity/ADR, cisplatin response - Efficacy, Toxicity/ADR, oxaliplatin response - Efficacy, Toxicity/ADR | 43,551,574(-) | T/C | coding_sequence_variant, missense_variant | |
rs761564262 | pathogenic, SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 26, Spinocerebellar ataxia, autosomal recessive, 26 (SCAR26) [MIM:617633] | 43,546,884(-) | C/G | coding_sequence_variant, missense_variant | |
VAR_036277 | A colorectal cancer sample | p.Arg350Trp | |||
rs1000096322 | -- | 43,568,461(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3603n100 | CNV | gain | 25217958 |
nsv1056785 | CNV | gain | 25217958 |
nsv1057657 | CNV | gain | 25217958 |
nsv1063149 | CNV | gain | 25217958 |
nsv1123259 | CNV | deletion | 24896259 |
nsv1134793 | CNV | deletion | 24896259 |
Additional Variant Information for XRCC1 Gene
Disorders for XRCC1 Gene

(25) MalaCards diseases for XRCC1 Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia, autosomal recessive 26 |
|
|
gastric cardia carcinoma |
|
|
sister chromatid exchange, frequency of |
|
|
fibrosclerosis of breast |
|
|
apraxia |
|
|
UniProtKB/Swiss-Prot
XRCC1_HUMAN- Spinocerebellar ataxia, autosomal recessive, 26 (SCAR26) [MIM:617633]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR26 is a progressive disease characterized by gait and limb ataxia, loss of independent ambulation, oculomotor apraxia, and peripheral neuropathy with distal muscle weakness and areflexia. {ECO:0000269 PubMed:28002403}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for XRCC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for XRCC1 Gene
Publications for XRCC1 Gene
- The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. (PMID: 11782372) Nelson HH … Karagas MR (Cancer research 2002) 3 4 22 44 58
- The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens. (PMID: 19908066) Artac M … Savas B (Journal of cancer research and clinical oncology 2010) 3 22 44 58
- DNA repair gene X-ray repair cross-complementing group 1 and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer: a study from North India. (PMID: 20070155) Mandal RK … Mittal RD (DNA and cell biology 2010) 3 22 44 58
- Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women. (PMID: 20140625) Sterpone S … Cozzi R (Journal of cancer research and clinical oncology 2010) 3 22 44 58
- Pterygium and genetic polymorphisms of the DNA repair enzymes XRCC1, XPA, and XPD. (PMID: 20431719) Chiang CC … Tsai FJ (Molecular vision 2010) 3 22 44 58
Products for XRCC1 Gene
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- Invitrogen Antibodies for XRCC1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for XRCC1
- antibodies-online: Search results for 126 available XRCC1 Antibodies ranked by validation data
- Compare Top XRCC1 Antibodies
- Recommended
- 103 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 19 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 26 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 3 available XRCC1 Elisa Kits ranked by validation data
- Compare Top XRCC1 Elisa Kits
- antibodies-online: Search results for 6 available XRCC1 Proteins ranked by validation data
- Compare Top XRCC1 Proteins
- GeneTex XRCC1 antibody for XRCC1
- Search GeneTex for Proteins for XRCC1
- ViGene Biosciences adenoviral particle packaged cDNA for XRCC1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XRCC1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XRCC1 gene
- Search ViGene Biosciences for XRCC1
- Santa Cruz Biotechnology (SCBT) Antibodies for XRCC1
- Search Santa Cruz Biotechnology (SCBT) for XRCC1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for XRCC1
- genomics-online: cdna clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
- orf clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
- genomics-online: gRNA clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
- genomics-online: primer clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
- genomics-online: shRNA clones - Search results for 93 available XRCC1 gene related products
- Overview of 93 available XRCC1 gene related products
Sources for XRCC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew