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XRCC1 Gene

protein-coding   GIFtS: 67
GCID: GC19M044047

X-Ray Repair Complementing Defective Repair In Chinese Hamster...


(Previous symbol: RCC)
  See XRCC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells
11 2
RCC1 2
X-Ray Repair Cross-Complementing Protein 12 3
DNA Repair Protein XRCC12

External Ids:    HGNC: 128281   Entrez Gene: 75152   Ensembl: ENSG000000730507   OMIM: 1943605   UniProtKB: P188873   

Export aliases for XRCC1 gene to outside databases

Previous GC identifers: GC19M044692 GC19M044439 GC19M048723 GC19M048739 GC19M040478


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XRCC1 Gene:
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by
exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta
and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA
processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is
associated with cancer in patients of varying radiosensitivity. (provided by RefSeq, Jul 2008)

GeneCards Summary for XRCC1 Gene:
XRCC1 (X-ray repair complementing defective repair in Chinese hamster cells 1) is a protein-coding gene. Diseases associated with XRCC1 include cardia cancer, and gastric cardia carcinoma. GO annotations related to this gene include damaged DNA binding. An important paralog of this gene is LOC100133315.

UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887
Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with
ionizing radiation and alkylating agents

Gene Wiki entry for XRCC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the XRCC1 gene promoter:
         STAT1   STAT1beta   CUTL1   LCR-F1   AP-2gamma   NF-kappaB   COMP1   c-Myb   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): XRCC1 promoter sequence
   Search Chromatin IP Primers for XRCC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XRCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

XRCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XRCC1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044047:  view genomic region     (about GC identifiers)

Start:
44,047,192 bp from pter      End:
44,084,625 bp from pter
Size:
37,434 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887 (See protein sequence)
Recommended Name: DNA repair protein XRCC1  
Size: 633 amino acids; 69477 Da
Subunit: Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III
(LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases
with the acetylated form of APEX1
Selected PDB 3D structures from and Proteopedia for XRCC1 (see all 8):
1CDZ (3D)        1XNA (3D)        1XNT (3D)        2D8M (3D)        2W3O (3D)        3K75 (3D)    
Secondary accessions: Q6IBS4 Q9HCB1

Explore the universe of human proteins at neXtProt for XRCC1: NX_P18887

Explore proteomics data for XRCC1 at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and
    APLF1
  • Sumoylated1
  • Glycosylation2 at Thr296, Thr440, Ser446, Ser447, Thr453
  • Modification sites at PhosphoSitePlus

  • See XRCC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006288.2  
    ENSEMBL proteins: 
     ENSP00000262887   ENSP00000443671   ENSP00000470391   ENSP00000470045   ENSP00000472128  
     ENSP00000471159  
    Reactome Protein details: P18887

    XRCC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for XRCC1

     
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    Search eBioscience for ELISAs for XRCC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008979 Galactose-bd-like
     IPR002706 Xrcc1_N
     IPR001357 BRCT_dom

    Graphical View of Domain Structure for InterPro Entry P18887

    ProtoNet protein and cluster: P18887

    2 Blocks protein domains:
    IPB001357 BRCT domain
    IPB002706 DNA-repair protein Xrcc1


    UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887
    Similarity: Contains 2 BRCT domains


    Find genes that share domains with XRCC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XRCC1_HUMAN, P18887
    Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with
    ionizing radiation and alkylating agents

         Genatlas biochemistry entry for XRCC1:
    repair X-ray defect,complementing defect in CHO cells,1,involved in single-strand DNA break
    rejoining,susceptibility gene for squamous cell carcinoma of the head and neck

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IEA--
    GO:0005515protein binding IPI14755728
         
    Find genes that share ontologies with XRCC1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for XRCC1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Xrcc1):
     behavior/neurological  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  nervous system  normal  tumorigenesis 

    Find genes that share phenotypes with XRCC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Xrcc1tm1Rpe for XRCC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XRCC1
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    hsa-mir-92b-3p (MIRT040679), hsa-mir-186-5p (MIRT045144), hsa-mir-193b-3p (MIRT041371), hsa-mir-34a-5p (MIRT025546)

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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XRCC1_HUMAN, P18887: Nucleus. Note=Accumulates at sites of DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with XRCC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XRCC1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Resolution of AP sites via the single-nucleotide replacement pathway0.00
    Base excision repair0.53
    Base Excision Repair0.00
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    3DNA Repair
    DNA Repair0.45
    4Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32
    5Meiosis (EMD)
    Meiosis


    Find genes that share SuperPaths with XRCC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for XRCC1
        DNA Repair Mechanisms

    2 Cell Signaling Technology (CST) Pathways for XRCC1
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 BioSystems Pathways for XRCC1
        E2F transcription factor network
    FOXM1 transcription factor network

    1 Reactome Pathway for XRCC1
        Resolution of AP sites via the single-nucleotide replacement pathway


    1 Kegg Pathway  (Kegg details for XRCC1):
        Base excision repair

        Pathway & Disease-focused RT2 Profiler PCR Arrays including XRCC1: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for XRCC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for XRCC1 (P188871, 2, 3 ENSP000002628874) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E31, 2, 3, ENSP000004008064EBI-947466,EBI-847814 MINT-2864208 MINT-51181 MINT-51153 MINT-51140 MINT-51142 MINT-51182 MINT-51154 MINT-51139 MINT-2864189 MINT-51230 I2D: score=5 STRING: ENSP00000400806
    CHEK2O960171, 2, 3, ENSP000003720234EBI-947466,EBI-1180783 MINT-7295039 MINT-7294980 MINT-7294997 MINT-7294787 MINT-7295015 MINT-7295027 MINT-7294756 MINT-7294958 I2D: score=1 STRING: ENSP00000372023
    POLIQ9UNA41, 2, 3, ENSP000002178004EBI-947466,EBI-741774 MINT-7296097 MINT-7296110 I2D: score=1 STRING: ENSP00000217800
    CCNOP226742, 3, ENSP000002825724MINT-7294905 MINT-7294888 I2D: score=1 STRING: ENSP00000282572
    H2AFXP161042, 3, ENSP000003643104MINT-7543857 I2D: score=1 STRING: ENSP00000364310
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000012single strand break repair IEA--
    GO:0001666response to hypoxia IEA--
    GO:0006281DNA repair TAS--
    GO:0006284base-excision repair TAS--
    GO:0006974cellular response to DNA damage stimulus ----

    Find genes that share ontologies with XRCC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XRCC1

    Selected Novoseek inferred chemical compound relationships for XRCC1 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polynucleotide 65.7 12 11163244 (3), 19910369 (2), 17650498 (1), 17353262 (1) (see all 8)
    8-oxoguanine 63.6 8 18349297 (1), 12933815 (1), 15927541 (1), 18393249 (1) (see all 7)
    lead chromate 59.8 8 16714390 (3), 16597656 (3)
    vinylchloride 57.1 21 12739102 (4), 12010862 (3), 16881598 (2), 17555083 (2) (see all 7)
    methylmethanesulfonate 51.9 10 15867196 (2), 17603793 (1), 15781218 (1), 11909950 (1) (see all 6)
    mspi 51.1 5 18364571 (1), 19176223 (1), 17418242 (1), 14639127 (1)
    methoxyamine 47.3 1 11585361 (1)
    oxaliplatin 44.2 6 17273745 (2), 15213713 (1), 17009149 (1), 11712813 (1)
    adpribose 41.4 9 14500814 (5), 16963444 (2), 11016934 (1), 12198176 (1)
    gsts 36.4 1 11708327 (1)

    7 PharmGKB related drug/compound annotations for XRCC1 gene    About this table
    Drug/compound PharmGKB Annotation
    Platinum compoundsCA  
    carboplatinCA  
    cisplatinCA  
    cyclophosphamideCA  
    fluorouracilCA  
    oxaliplatinCA  
    platinumCA  



    Find genes that share compounds with XRCC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XRCC1 gene: 
    NM_006297.2  

    Unigene Cluster for XRCC1:

    X-ray repair complementing defective repair in Chinese hamster cells 1
    Hs.98493  [show with all ESTs]
    Unigene Representative Sequence: NM_006297
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262887(uc002owt.2 uc010xwp.1) ENST00000543982 ENST00000597811
    ENST00000595789 ENST00000598422 ENST00000598165 ENST00000599693 ENST00000594107
    ENST00000594511
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    GenScript: all cDNA clones in your preferred vector: XRCC1 (NM_006297)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XRCC1
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    Addgene plasmids for XRCC1 
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    Flow Cytometry
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    Additional mRNA sequence: 

    AB208781.1 AK293542.1 AK300163.1 AK315332.1 BC023593.2 CR456728.1 

    13 DOTS entries:

    DT.452311  DT.91761768  DT.100773970  DT.100027795  DT.100782706  DT.100782718  DT.100782719  DT.87016286 
    DT.100637811  DT.95107355  DT.121484346  DT.87016288  DT.91724728 

    Selected AceView cDNA sequences (see all 374):

    CR591751 F13079 F06425 AA722476 BQ057273 AI125175 BM831688 AW002217 
    AI168181 AW613956 BQ882089 BX091022 AA426207 BQ896139 F08201 BE252183 
    BM831569 CR614880 BM928576 CR617745 AI206971 F05480 AA402560 BX452522 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for XRCC1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                -                       -                                                                                                   
    SP2:                                -                       -                                                                                                   
    SP3:                                                                                                                                                            
    SP4:                                -                       -                                                                                                   
    SP5:                                                        -                 -     -     -                                                                     


    ECgene alternative splicing isoforms for XRCC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    XRCC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGGCCAG
    XRCC1 Expression
    About this image


    XRCC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    XRCC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XRCC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98493
        Pathway & Disease-focused RT2 Profiler PCR Arrays including XRCC1: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for XRCC1
    OriGene qSTAR qPCR primer pairs in human, mouse for XRCC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XRCC1
    QuantiTect SYBR Green Assays in human, mouse, rat XRCC1
    QuantiFast Probe-based Assays in human, mouse, rat XRCC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for XRCC1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xrcc11 , 5 X-ray repair complementing defective repair in Chinese more1, 5 84.79(n)1
    86.49(a)1
      7 (11.42 cM)5
    225941  NM_009532.41  NP_033558.31 
     245471505 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    54(a)
    1 → many
    LGf(1127269-1140959)
    African clawed frog
    (Xenopus laevis)
    Amphibia xrcc1-prov2 x-ray repair cross-complementing group 1 protein 76.58(n)    BC045032.1 
    zebrafish
    (Danio rerio)
    Actinopterygii xrcc11 X-ray repair complementing defective repair in Chinese more 57.71(n)
    54.26(a)
      445480  NM_001003988.1  NP_001003988.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta XRCC13 nucleotide-excision repair 40(a)   4F5   --


    ENSEMBL Gene Tree for XRCC1 (if available)
    TreeFam Gene Tree for XRCC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for XRCC1 gene
    LOC1001333152  ENSG000002683612  

    Find genes that share paralogs with XRCC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    XRCC1_HUMAN, P18887: Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA
    damage


    Selected SNPs for XRCC1 (see all 898)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362774
    A colorectal cancer sample4--see VAR_0362772 R W mis40--------
    rs455921421,2
    C--40478190(+) TGTGT-/GTGTGT
    GTGTGTGT
    ATAGC
    1 -- cds10--------
    rs126097701,2
    C,H--44047004(+) CAATCA/GCCTCA 1 -- ds50012Minor allele frequency- G:0.00NA 4
    rs1847934601,2
    --44047027(+) ATGTGG/TTGGAG 1 -- ds50010--------
    rs1895263581,2
    --44047218(+) AGCCTA/CATGGG 1 -- ds50010--------
    rs1415786561,2
    --44047231(+) CCAGG-/CCCTCC 1 -- ds50010--------
    rs32134011,2
    C,F--44047312(-) GAACTGGGA    
       ATC
    /-
    TGACC
    1 -- ds50011Minor allele frequency- -:0.14NS 178
    rs1425717171,2
    C--44047314(+) TCAGA-/TT    
       CCCAG
    TTCCC
    1 -- ds50010--------
    rs26825581,2
    C,F--44047316(-) ACTGGG/AAATCT 1 -- ds50014Minor allele frequency- A:0.10NS WA NA 178
    rs1473053871,2
    --44047364(+) CAGAAA/GAGACA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for XRCC1 (44047192 - 44084625 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for XRCC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912107CNV Loss21882294

    Human Gene Mutation Database (HGMD): XRCC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XRCC1
    DNA2.0 Custom Variant and Variant Library Synthesis for XRCC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194360    OMIM disorders: --

    11 diseases for XRCC1:    
    About MalaCards
    cardia cancer    gastric cardia carcinoma    bladder cancer susceptibility    mutagen sensitivity
    oral leukoplakia    xeroderma pigmentosum, group d    microtia    squamous cell carcinoma of the head and neck
    colorectal cancer    lung cancer    breast cancer

    6 diseases from the University of Copenhagen DISEASES database for XRCC1:
    Xeroderma pigmentosum     Lung cancer     Breast cancer     Carcinoma
    Urinary bladder cancer     Colorectal cancer

    Find genes that share disorders with XRCC1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for XRCC1 gene (see all 45)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 73.7 28 11016934 (1), 17593927 (1), 19109787 (1), 19657998 (1) (see all 26)
    cancer 60.3 79 16172217 (6), 15896924 (4), 16550161 (4), 16137195 (3) (see all 48)
    cancer lung 58.1 77 18999926 (4), 17417947 (4), 19481337 (4), 12618330 (3) (see all 34)
    nsclc 50.5 31 19958624 (3), 19683826 (2), 15534883 (2), 16157195 (2) (see all 13)
    bladder cancer 46.2 30 18272472 (5), 18336890 (3), 20514470 (2), 12223443 (2) (see all 15)
    neck cancer 44.8 7 19846968 (2), 11867203 (1), 18833034 (1), 19643719 (1)
    carcinoma squamous cell 44.7 19 17614107 (2), 19444915 (2), 19230024 (2), 1574572 (1) (see all 15)
    breast cancer 44.6 106 16457697 (6), 15666192 (5), 18481169 (5), 15734955 (4) (see all 42)
    genetic susceptibility 43.6 5 15666192 (1), 15252855 (1), 17385092 (1), 19673050 (1) (see all 5)
    colorectal cancer 43.3 30 18806752 (4), 15800946 (3), 20033188 (3), 17009149 (3) (see all 13)

    Genetic Association Database (GAD): XRCC1
    Human Genome Epidemiology (HuGE) Navigator: XRCC1 (589 documents)

    Export disorders for XRCC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XRCC1 gene, integrated from 10 sources (see all 1000) (see top 10):
    (articles sorted by number of sources associating them with XRCC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. (PubMed id 11782372)1, 2, 4, 9 Nelson H.H.... Karagas M.R. (Cancer Res. 2002)
    2. Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. (PubMed id 2247054)1, 2, 3 Thompson L.H.... Carrano A.V. (Mol. Cell. Biol. 1990)
    3. Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (Codon 280). (PubMed id 16172217)1, 4, 9 Majumder M....Roy B. (amp 2005)
    4. A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. (PubMed id 12183419)1, 4, 9 Duell E.J....Kelsey K.T. (Cancer Res. 2002)
    5. Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma. (PubMed id 19230024)1, 4, 9 Applebaum K.M....Kelsey K.T. (Int. J. Cancer 2009)
    6. XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk. (PubMed id 15767338)1, 4, 9 Stern M.C....Haile R.W. (amp 2005)
    7. The association of XRCC1 gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma. (PubMed id 19563645)1, 4, 9 Cheng X.D....Xie X. (amp 2009)
    8. DNA repair gene hOGG1 codon 326 and XRCC1 codon 399 polymorphisms and bladder cancer risk in a Japanese population. (PubMed id 18272472)1, 4, 9 Arizono K....Kuroda Y. (Jpn. J. Clin. Oncol. 2008)
    9. XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage. (PubMed id 16397295)1, 2, 9 Levy N....Menissier-de Murcia J. (Nucleic Acids Res. 2006)
    10. XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking. (PubMed id 16510609)1, 4, 9 Pachkowski B.F....Nakamura J. (Cancer Res. 2006)
    11. Which gene is a dominant predictor of response during FOLFOX chemotherapy for the treatment of metastatic colorectal cancer, the MTHFR or XRCC1 gene? (PubMed id 17009149)1, 4, 9 Suh K.W....Choi S. (Ann. Surg. Oncol. 2006)
    12. An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer. (PubMed id 16596326)1, 4, 9 Bu D....Euhus D.M. (Breast Cancer Res. Treat. 2006)
    13. A prospective study of XRCC1 (X-ray cross-complementing group 1) polymorphisms and breast cancer risk. (PubMed id 16457697)1, 4, 9 Patel A.V....Rodriguez C. (Breast Cancer Res. 2005)
    14. Genetic polymorphism of p53 and XRCC1 in cervical intraepithelial neoplasm in Taiwanese women. (PubMed id 15216398)1, 4, 9 Wu M.T....Wu T.N. (J. Formos. Med. Assoc. 2004)
    15. Polymorphism of XRCC1 (at codon 399) and susceptibility to breast cancer, a meta-analysis of the literatures. (PubMed id 18481169)1, 4, 9 Saadat M. and Ansari-Lari M. (Breast Cancer Res. Treat. 2009)
    16. XRCC1 codon 280 and ERCC2 codon 751 polymorphisms and risk of esophageal squamous cell carcinoma in a Chinese population. (PubMed id 19762325)1, 4, 9 Zhai X.D....Ye Y. (Bull Cancer 2009)
    17. Association between X-ray repair cross complementing group 1 codon 399 and 194 polymorphisms and lung cancer risk: a meta-analysis. (PubMed id 19481337)1, 4, 9 Wang Y....Zheng Y. (Cancer Lett. 2009)
    18. The polymorphism and haplotypes of XRCC1 and survival of non-small-cell lung cancer after radiotherapy. (PubMed id 16199318)1, 4, 9 Yoon S.M....Choi E.K. (Int. J. Radiat. Oncol. Biol. Phys. 2005)
    19. XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy. (PubMed id 15173214)1, 4, 9 Gurubhagavatula S....Christiani D.C. (J. Clin. Oncol. 2004)
    20. Polymorphisms in the DNA repair gene XRCC1 and breast cancer. (PubMed id 11303590)1, 4, 9 Duell E.J....Bell D.A. (amp 2001)
    21. Pterygium and genetic polymorphisms of the DNA repair enzymes XRCC1, XPA, and XPD. (PubMed id 20431719)1, 4, 9 Chiang C.C....Tsai F.J. (Mol. Vis. 2010)
    22. DNA repair gene X-ray repair cross-complementing group 1 and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer: a study from North India. (PubMed id 20070155)1, 4, 9 Mandal R.K....Mittal R.D. (DNA Cell Biol. 2010)
    23. The influence of variations in the DNA repair (XRCC1) gene on HIV-1/AIDS among Indian population. (PubMed id 19863846)1, 4, 9 Sobti R.C....Wanchu A. (Folia Biol. (Praha) 2009)
    24. Variant haplotypes at XRCC1 and risk of oral leukoplakia in HPV non-infected samples. (PubMed id 18764855)1, 4, 9 Majumder M....Roy B. (amp 2009)
    25. Contrasting impact of DNA repair gene XRCC1 polymorphisms Arg399Gln and Arg194Trp on the risk of lung cancer in the north-Indian population. (PubMed id 17417947)1, 4, 9 Pachouri S.S....Singh J. (DNA Cell Biol. 2007)
    26. Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma. (PubMed id 16621887)1, 4, 9 Li C....Wei Q. (Carcinogenesis 2006)
    27. [Association of genetic polymorphism of XRCC1 with susceptibility to acute childhood leukemia]. (PubMed id 16111035)1, 4, 9 Zhu R....Xia Z. (Wei Sheng Yan Jiu 2005)
    28. Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer. (PubMed id 15666192)1, 4, 9 Chacko P....Pillai M.R. (Breast Cancer Res. Treat. 2005)
    29. Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk. (PubMed id 15734955)1, 4, 9 Shen J....Santella R.M. (amp 2005)
    30. The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms. (PubMed id 15534883)1, 4, 9 Liu G....Christiani D.C. (Cancer 2004)
    31. Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients. (PubMed id 15665590)1, 4, 9 Deligezer U. and Dalay N. (amp 2004)
    32. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. (PubMed id 14679022)1, 4, 9 Han J....Hunter D.J. (Cancer Res. 2003)
    33. XRCC1 and CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers. (PubMed id 12010862)1, 4, 9 Wong R.H....Cheng T.J. (amp 2002)
    34. The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens. (PubMed id 19908066)1, 4, 9 Artac M....Savas B. (J. Cancer Res. Clin. Oncol. 2010)
    35. XRCC1 polymorphisms and risk of colorectal cancer: a meta-analysis. (PubMed id 20033188)1, 4, 9 Wang B....Zhou W. (Int J Colorectal Dis 2010)
    36. XRCC1 and XRCC3 DNA repair gene polymorphisms in breast cancer women from the Lodz region of Poland. (PubMed id 19886181)1, 4, 9 Sobczuk A....Smolarz B. (Pol J Pathol 2009)
    37. Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. (PubMed id 19155274)1, 2, 9 Ali A.A.... Oliver A.W. (Nucleic Acids Res. 2009)
    38. XRCC1 genetic polymorphism Arg399Gln and prostate cancer risk: a meta-analysis. (PubMed id 19428062)1, 4, 9 Geng J....Chen L. (Urology 2009)
    39. Association between polymorphisms of the DNA repair genes XRCC1 and hOGG1 and type 2 diabetes mellitus in the Polish population. (PubMed id 19514640)1, 4, 9 Kasznicki J....Drzewoski J. (Pol. Arch. Med. Wewn. 2009)
    40. Polymorphisms of DNA base-excision repair genes APE/Ref-1 and XRCC1 are not associated with the risk for Graves' disease. (PubMed id 19711438)1, 4, 9 DoA9ru-AbbasoA9lu S....Uysal M. (Cell Biochem. Funct. 2009)
    41. [Correlation of the sensitivity of NP chemotherapy in non-small lung cancer with DNA repair gene XRCC1 polymorphism]. (PubMed id 19958624)1, 4, 9 Hong C.Y....Yuan Y. (Ai Zheng 2009)
    42. Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma. (PubMed id 20003463)1, 4, 9 Yin Z....Li X. (BMC Cancer 2009)
    43. The p21 codon 31*C- and DRD2 codon 313*T-related genotypes/alleles, but not XRCC1 codon 399, hOGG1 codon 326, and DRD1-48 polymorphisms, are correlated with the presence of leiomyoma. (PubMed id 19176223)1, 4, 9 Hsieh Y.Y....Chen C.P. (Fertil. Steril. 2009)
    44. Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p53 gene in hepatocellular carcinoma among Guangxi population, China. (PubMed id 17849423)1, 4, 9 Long X.D....Lu Y.L. (Mol. Carcinog. 2008)
    45. No association between the Arg194Trp and Arg399Gln polymorphisms of the XRCC1 gene and colorectal cancer risk and progression in a Polish population. (PubMed id 18806752)1, 4, 9 Sliwinski T....Blasiak J. (Exp. Oncol. 2008)
    46. Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population (Fars province, southern Iran). (PubMed id 17874204)1, 4, 9 Mohamadynejad P. and Saadat M. (Mol. Biol. Rep. 2008)
    47. XRCC1 codon 399 mutant allele: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy. (PubMed id 18364571)1, 4, 9 Mittal R.D....Mandhani A. (amp 2008)
    48. Polymorphisms of the XRCC1 and XPD genes and breast cancer risk: a case-control study. (PubMed id 18415712)1, 4, 9 KipikasovA! L....Mojzis J. (Pathol. Oncol. Res. 2008)
    49. XRCC1 genetic polymorphisms and bladder cancer susceptibility: a meta-analysis. (PubMed id 18336890)1, 4, 9 Wang C....Han R. (Urology 2008)
    50. Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. (PubMed id 18582155)1, 4, 9 Burri R.J....Rosenstein B.S. (Radiat. Res. 2008)
    51. Genetic polymorphism in the DNA repair gene XRCC1 and susceptibility to schizophrenia. (PubMed id 17961713)1, 4, 9 Saadat M....Farrashbandi H. (Psychiatry Res 2008)
    52. Polymorphisms in metabolic GSTP1 and DNA-repair XRCC1 genes with an increased risk of DNA damage in pesticide-exposed fruit growers. (PubMed id 18603015)1, 4, 9 Wong R.H....Lee H.S. (Mutat. Res. 2008)
    53. XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis. (PubMed id 19034980)1, 4, 9 Geng J....Chen L.B. (World J. Gastroenterol. 2008)
    54. Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. (PubMed id 17614107)1, 4, 9 Li C....Wei Q. (Cancer 2007)
    55. [Polymorphisms in XRCC1 and ERCC4/XPF DNA repair genes and associations with breast cancer risk in women]. (PubMed id 17682675)1, 4, 9 Romanowicz-Makowska H....Kulig A. (Pol. Merkur. Lekarski 2007)
    56. Prognostic significance of p53 and X-ray repair cross-complementing group 1 polymorphisms on prostate-specific antigen recurrence in prostate cancer post radical prostatectomy. (PubMed id 18006764)1, 4, 9 Huang S.P....Wu M.T. (Clin. Cancer Res. 2007)
    57. [Analysis for the association between genetic polymorphisms of XRCC1, XPD, XRCC3, CCND1 and the latency of the occupational chronic benzene poisoning]. (PubMed id 17605237)1, 4, 9 Xu J.N....Zheng Y.X. (Zhonghua Yu Fang Yi Xue Za Zhi 2007)
    58. [Family-based association study of XRCC1 gene polymorphisms in nasopharyngeal carcinoma]. (PubMed id 17767850)1, 4, 9 Pan Q.H....Jia W.H. (Zhonghua Yu Fang Yi Xue Za Zhi 2007)
    59. [Association of single nucleotide polymorphisms and haplotypes in DNA repair gene XRCC1 with susceptibility of breast cancer]. (PubMed id 16924699)1, 4, 9 Jin M.J....Ma X.Y. (Zhejiang Da Xue Xue Bao Yi Xue Ban 2006)
    60. Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. (PubMed id 16492913)1, 4, 9 Smedby K.E....Adami H.O. (amp 2006)
    61. Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer. (PubMed id 16890595)1, 4, 9 Miao X....Lin D. (Gastroenterology 2006)
    62. Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population. (PubMed id 16284386)1, 4, 9 Zhang Z....Xia Z. (amp 2005)
    63. XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. (PubMed id 16030121)1, 4, 9 Hu Z....Shen H. (amp 2005)
    64. Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes. (PubMed id 15990020)1, 4, 9 De Ruyck K....Thierens H. (Int. J. Radiat. Oncol. Biol. Phys. 2005)
    65. [Association of XRCC1 polymorphisms and chromosomal damage levels in coke-oven workers]. (PubMed id 15938843)1, 4, 9 Leng S.G....Zheng Y.X. (Zhonghua Yu Fang Yi Xue Za Zhi 2005)
    66. Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors: association with late clinical radiosensitivity and cancer incidence. (PubMed id 16137195)1, 4, 9 De Ruyck K....Thierens H. (Radiat. Res. 2005)
    67. Associations between XRCC1 and ERCC2 polymorphisms and DNA damage in peripheral blood lymphocyte among coke oven workers. (PubMed id 15764301)1, 4, 9 Leng S....Zheng Y. (Biomarkers 2004)
    68. XRCC1, CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers. (PubMed id 12739102)1, 4, 9 Wong R.H....Cheng T.J. (Arch. Toxicol. 2003)
    69. Gene-environment interactions between the codon 194 polymorphism of XRCC1 and antioxidants influence lung cancer risk. (PubMed id 12680158)1, 4, 9 Ratnasinghe D.L....Taylor P.R. (Anticancer Res. 2003)
    70. Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene. (PubMed id 12433703)1, 4, 9 van Gils C.H....Taylor J.A. (amp 2002)
    71. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. (PubMed id 11163244)1, 2, 9 Whitehouse C.J.... Caldecott K.W. (Cell 2001)
    72. Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. (PubMed id 9542526)1, 4, 9 Price E.A....Arrand J.E. (Somat. Cell Mol. Genet. 1997)
    73. Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women. (PubMed id 20140625)1, 4, 9 Sterpone S....Cozzi R. (J. Cancer Res. Clin. Oncol. 2010)
    74. Menopausal age and XRCC1 gene polymorphisms: role in breast cancer risk. (PubMed id 17935911)1, 4, 9 Silva S.N....Gaspar J. (Cancer Detect. Prev. 2007)
    75. Association between polymorphisms in the DNA repair genes XRCC1 and APE1, and the risk of prostate cancer in white and black Americans. (PubMed id 16406883)1, 4, 9 Chen L....Park J.Y. (J. Urol. 2006)
    76. Association of XRCC1 gene polymorphisms with the susceptibility and chromosomal aberration of testicular germ cell tumors. (PubMed id 16596238)1, 4, 9 Tsuchiya N....Habuchi T. (Int. J. Oncol. 2006)
    77. Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer. (PubMed id 15800946)1, 4, 9 Hong Y.C....Kim H. (Int. J. Cancer 2005)
    78. Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations? (PubMed id 15491645)1, 4, 9 Aka P....Kirsch-Volders M. (Mutat. Res. 2004)
    79. Influence of common XPD and XRCC1 variant alleles on p53 mutations in lung tumors. (PubMed id 12552590)1, 4, 9 Hou S.M....Husgafvel-Pursiainen K. (Environ. Mol. Mutagen. 2003)
    80. A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. (PubMed id 19915856)1, 4, 9 Jiang Z....Cai S. (Int J Colorectal Dis 2010)
    81. DNA repair genes in endometriosis. (PubMed id 20391347)1, 4, 9 Attar R....Agachan B. (Genet. Mol. Res. 2010)
    82. Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk. (PubMed id 20514470)1, 4, 9 Gao W....Keohavong P. (Oncol. Rep. 2010)
    83. Association between genetic polymorphism in DNA repair genes and risk of B-cell lymphoma. (PubMed id 19657998)1, 4, 9 Baris S....Yildiz I. (Pediatr Hematol Oncol 2009)
    84. Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer. (PubMed id 19672255)1, 4, 9 Chua W....Iacopetta B. (Br. J. Cancer 2009)
    85. XRCC1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. (PubMed id 19329222)1, 4, 9 Zheng H....Wang Z. (Lung Cancer 2009)
    86. XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk: a meta-analysis. (PubMed id 19465687)1, 4, 9 Huang Y....Yu L. (Mutagenesis 2009)
    87. Polymorphisms in p53, GSTP1 and XRCC1 predict relapse and survival of gastric cancer patients treated with oxaliplatin-based adjuvant chemotherapy. (PubMed id 19247656)1, 4, 9 Huang Z.H....Du X. (Cancer Chemother. Pharmacol. 2009)
    88. XRCC1 gene polymorphisms and esophageal squamous cell carcinoma risk in Chinese population: A meta-analysis of case-control studies. (PubMed id 19444915)1, 4, 9 Dai L....Wang Y. (Int. J. Cancer 2009)
    89. Association between XRCC1 polymorphisms and head and neck cancer in a Hungarian population. (PubMed id 19846968)1, 4, 9 Csejtei A....Kiss I. (Anticancer Res. 2009)
    90. Implications of XRCC1, XPD and APE1 gene polymorphism in North Indian population: a comparative approach in different ethnic groups worldwide. (PubMed id 18946634)1, 4, 9 Gangwar R....Mittal R.D. (Genetica 2009)
    91. Genetic polymorphisms in XRCC1, OGG1, APE1 and XRCC3 DNA repair genes, ionizing radiation exposure and chromosomal DNA damage in interventional cardiologists. (PubMed id 19393248)1, 4, 9 Andreassi M.G....Picano E. (Mutat. Res. 2009)
    92. XRCC1 gene polymorphisms and breast cancer risk in different populations: a meta-analysis. (PubMed id 19446452)1, 4, 9 Li H....Tai B.C. (Breast 2009)
    93. Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). (PubMed id 19414392)1, 4, 9 Narter K.F....Isbir T. (Anticancer Res. 2009)
    94. Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients. (PubMed id 19157633)1, 4, 9 Sun X....Yingfeng Z. (Lung Cancer 2009)
    95. Effect of polymorphisms in XRCC1, CCND1 and GSTM1 and tobacco exposure as risk modifier for oral leukoplakia. (PubMed id 19634112)1, 4, 9 Yadav B.K....Ralhan R. (Int. J. Biol. Markers 2009)
    96. ERCC1 and XRCC1 gene polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer. (PubMed id 19421825)1, 4, 9 Warnecke-Eberz U....Metzger R. (J. Gastrointest. Surg. 2009)
    97. Contribution of XPD (Lys751Gln) and XRCC1 (Arg399Gln) polymorphisms in familial and sporadic breast cancer predisposition and survival: an Indian report. (PubMed id 19051060)1, 4, 9 Syamala V.S....Ankathil R. (Pathol. Oncol. Res. 2009)
    98. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. (PubMed id 19101034)1, 4, 9 Batar B....Yildiz I. (Leuk. Res. 2009)
    99. Genetic polymorphisms in DNA repair gene APE1, XRCC1 and XPD and the risk of pre-eclampsia. (PubMed id 19592152)1, 4, 9 Vural P....Uysal M. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2009)
    100. XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. (PubMed id 18407370)1, 4, 9 Li M....Zhou B. (Lung Cancer 2008)
    101. XRCC1 polymorphisms and severe toxicity in lung cancer patients treated with cisplatin-based chemotherapy in Chinese population. (PubMed id 18400332)1, 4, 9 Wang Z....Hu X. (Lung Cancer 2008)
    102. Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women. (PubMed id 18669164)1, 4, 9 Mitra A.K....Rath S.K. (Oncol. Res. 2008)
    103. Significance of amino acid substitution variants of DNA repair genes in radiosusceptibility of cervical cancer patients; a pilot study. (PubMed id 18505345)1, 4, 9 Farkasova T....Gabelova A. (Neoplasma 2008)
    104. DNA repair gene ERCC2, XPC, XRCC1, XRCC3 polymorphisms and associations with bladder cancer risk in a French cohort. (PubMed id 18630471)1, 4, 9 Fontana L....Bernard-Gallon D.J. (Anticancer Res. 2008)
    105. Genetic polymorphisms of XRCC1 (codon 399) and susceptibility to breast cancer in Iranian women, a case-control study. (PubMed id 17987379)1, 4, 9 Saadat M....Omidvari S. (Breast Cancer Res. Treat. 2008)
    106. Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma. (PubMed id 18779313)1, 4, 9 Chiang F.Y....Juo S.H. (Clin. Cancer Res. 2008)
    107. Polymorphisms in three base excision repair genes and breast cancer risk in Thai women. (PubMed id 17922186)1, 4, 9 Sangrajrang S....Popanda O. (Breast Cancer Res. Treat. 2008)
    108. [Correlations of single nucleotide polymorphisms of DNA repair gene XRCC1 to risk of colorectal cancer]. (PubMed id 17355790)1, 4, 9 Jin M.J....Zhang Y.J. (Ai Zheng 2007)
    109. Relationship between XRCC1 polymorphisms and susceptibility to prostate cancer in men from Han, Southern China. (PubMed id 17486273)1, 4, 9 Xu Z....Wu H.F. (Asian J. Androl. 2007)
    110. DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas. (PubMed id 17898525)1, 4, 9 Felini M.J....Wrensch M.R. (Neuroepidemiology 2007)
    111. [Study of susceptibility of chromosomal damage induced by vinyl chloride monomer associated with genetic polymorphism in APE1, XRCC1]. (PubMed id 17555083)1, 4, 9 Qiu Y....Xia Z. (Wei Sheng Yan Jiu 2007)
    112. DNA repair gene XRCC1 polymorphisms and bladder cancer risk. (PubMed id 17425776)1, 4, 9 Sak S.C....Kiltie A.E. (BMC Genet. 2007)
    113. Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia. (PubMed id 16435384)1, 4, 9 Pakakasama S....Hongeng S. (amp 2007)
    114. Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain. (PubMed id 17705814)1, 4, 9 LA^pez-Cima M.F....TardA^n A. (BMC Cancer 2007)
    115. DNA-repair and carcinogen-metabolising enzymes genetic polymorphisms as an independent risk factor for hepatocellular carcinoma in Caucasian liver-transplanted patients. (PubMed id 17870518)1, 4, 9 Borentain P....GAcrolami R. (Eur. J. Cancer 2007)
    116. XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk. (PubMed id 17264068)1, 4, 9 Liu G....Christiani D.C. (Carcinogenesis 2007)
    117. DNA repair gene XRCC1 and XPD polymorphisms and the risk of idiopathic azoospermia in a Chinese population. (PubMed id 17912469)1, 4, 9 Gu A....Wang X. (Int. J. Mol. Med. 2007)
    118. The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden. (PubMed id 16571649)1, 4, 9 Ye W....NyrAcn O. (Carcinogenesis 2006)
    119. [Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC1 to risk of gastric cancer]. (PubMed id 16405741)1, 4, 9 Zhang Z....Lin D.X. (Ai Zheng 2006)
    120. DNA repair gene polymorphisms and probability of p53 mutation in bladder cancer. (PubMed id 16652373)1, 4, 9 Stern M.C....Taylor J.A. (Mol. Carcinog. 2006)
    121. The role of XRCC1 polymorphisms in base excision repair of etheno-DNA adducts in French vinyl chloride workers. (PubMed id 16881598)1, 4, 9 Li Y....Brandt-Rauf P.W. (Int J Occup Med Environ Health 2006)
    122. Analysis of the XRCC1 gene as a modifier of the cerebral response in ischemic stroke. (PubMed id 17087834)1, 4, 9 Dutra A.V....Grewal R.P. (BMC Med. Genet. 2006)
    123. Polymorphisms of the DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp): relationship to breast cancer risk and familial predisposition to breast cancer. (PubMed id 16319991)1, 4, 9 Brewster A.M....Helzlsouer K.J. (Breast Cancer Res. Treat. 2006)
    124. A combined analysis of XRCC1, XRCC3, GSTM1 and GSTT1 polymorphisms and centromere content of micronuclei in welders. (PubMed id 16551674)1, 4, 9 Iarmarcovai G....Botta A. (Mutagenesis 2006)
    125. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)1, 4, 9 Zienolddiny S....Haugen A. (Carcinogenesis 2006)
    126. Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies. (PubMed id 16997330)1, 4, 9 Skjelbred C.F....Hansteen I.L. (Mutat. Res. 2006)
    127. Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. (PubMed id 17034901)1, 4, 9 Ryk C....Hou S.M. (Lung Cancer 2006)
    128. Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study. (PubMed id 16542436)1, 4, 9 Skjelbred C.F....Kure E.H. (BMC Cancer 2006)
    129. XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk. (PubMed id 17164360)1, 4, 9 Stern M.C....Haile R.W. (amp 2006)
    130. [XRCC1 and XPD genetic polymorphisms predict clinical responses to platinum-based chemotherapy in advanced non-small cell lung cancer]. (PubMed id 16875604)1, 4, 9 Yuan P....Lin D.X. (Zhonghua Zhong Liu Za Zhi 2006)
    131. Influence of hOGG1, XRCC1 and XRCC3 genotypes on biomarkers of genotoxicity in workers exposed to cobalt or hard metal dusts. (PubMed id 15737490)1, 4, 9 Mateuca R....Lison D. (Toxicol. Lett. 2005)
    132. XRCC1 and XPD genetic polymorphisms, smoking and breast cancer risk in a Finnish case-control study. (PubMed id 16280050)1, 4, 9 Metsola K....Hirvonen A. (Breast Cancer Res. 2005)
    133. Polymorphisms of the XRCC1, XRCC3, &amp; XPD genes, and colorectal cancer risk: a case-control study in Taiwan. (PubMed id 15679883)1, 4, 9 Yeh C.C....Hsieh L.L. (BMC Cancer 2005)
    134. Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study. (PubMed id 16284380)1, 4, 9 Matullo G....Vineis P. (amp 2005)
    135. Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients. (PubMed id 16000577)1, 4, 9 Chang-Claude J....Ambrosone C.B. (Clin. Cancer Res. 2005)
    136. Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China. (PubMed id 15816625)1, 4, 9 Shen M....Lan Q. (Anticancer Res. 2005)
    137. DNA repair and cyclin D1 polymorphisms and styrene-induced genotoxicity and immunotoxicity. (PubMed id 15992842)1, 4, 9 Kuricova M....Vodicka P. (Toxicol. Appl. Pharmacol. 2005)
    138. Polymorphisms of DNA repair genes and risk of glioma. (PubMed id 15313891)1, 4, 9 Wang L.E....Wei Q. (Cancer Res. 2004)
    139. An association of polymorphism of DNA repair genes XRCC1 and XRCC3 with colorectal cancer. (PubMed id 15354414)1, 4, 9 Krupa R. and Blasiak J. (amp 2004)
    140. [Relation of genetic polymorphism of XRCC1 with risks of chronic benzene poisoning]. (PubMed id 15612468)1, 4, 9 Zhang Z....Xia Z. (Wei Sheng Yan Jiu 2004)
    141. [Single nucleotide polymorphisms in XRCC1 and clinical response to platin-based chemotherapy in advanced non-small cell lung cancer]. (PubMed id 15301704)1, 4, 9 Wang Z.H....Lin D.X. (Ai Zheng 2004)
    142. Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. (PubMed id 15333465)1, 4, 9 Popanda O....Schmezer P. (Carcinogenesis 2004)
    143. Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer. (PubMed id 12844488)1, 4, 9 Gao W.M....Keohavong P. (Carcinogenesis 2003)
    144. Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1. (PubMed id 14578150)1, 4, 9 Cho E.Y....Yang C.S. (amp 2003)
    145. Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk. (PubMed id 12692111)1, 4, 9 Zhou W....Christiani D.C. (amp 2003)
    146. Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. (PubMed id 12565173)1, 4, 9 Smith T.R....Hu J.J. (Cancer Lett. 2003)
    147. A common polymorphism in XRCC1 as a biomarker of susceptibility for chemically induced genetic damage. (PubMed id 14602524)1, 4, 9 Li Y....Brandt-Rauf P.W. (Biomarkers 2003)
    148. Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes. (PubMed id 11872635)1, 4, 9 Qiao Y....Wei Q. (Carcinogenesis 2002)
    149. The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia. (PubMed id 12393447)1, 4, 9 Seedhouse C....Das-Gupta E. (Blood 2002)
    150. Genetic polymorphisms of XRCC1 and risk of gastric cancer. (PubMed id 12359351)1, 4, 9 Lee S.G....Song K. (Cancer Lett. 2002)
    151. Genetic polymorphism of XRCC1 and lung cancer risk among African-Americans and Caucasians. (PubMed id 11714530)1, 4, 9 David-Beabes G.L. and London S.J. (Lung Cancer 2001)
    152. Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. (PubMed id 10783319)1, 2, 9 Duell E.J.... Kelsey K.T. (Carcinogenesis 2000)
    153. Association between polymorphisms of XRCC1 and offspring sex ratio at births in families of female breast cancer patients. (PubMed id 19701703)1, 4, 9 Saadat M. and Saadat I. (Breast Cancer Res. Treat. 2010)
    154. Polymorphisms in hOGG1 and XRCC1 and risk of prostate cancer: effects modified by plasma antioxidants. (PubMed id 19914697)1, 4, 9 Zhang J....Kadlubar F.F. (Urology 2010)
    155. DNA repair gene XRCC1 polymorphisms and haplotypes in diffuse large B-cell lymphoma in a Korean population. (PubMed id 19963133)1, 4, 9 Kim I.S....Lee G.W. (Cancer Genet. Cytogenet. 2010)
    156. DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients. (PubMed id 19962393)1, 4, 9 Sterpone S....Donato V. (Mutat. Res. 2010)
    157. Synergistic effects of polymorphisms in DNA repair genes and endogenous estrogen exposure on female breast cancer risk. (PubMed id 20183911)1, 4, 9 Ming-Shiean H....Cheng C.W. (Ann. Surg. Oncol. 2010)
    158. Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. (PubMed id 19902366)1, 4, 9 Agalliu I....Stanford J.L. (amp 2010)
    159. Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response. (PubMed id 20504250)1, 4, 9 Balboa E....Barros F. (Pharmacogenomics 2010)
    160. [Relationship between polymorphisms of X-ray repair cross-complementing group 1 gene Arg194Trp, Arg399Gln and susceptibility of breast cancer]. (PubMed id 20450747)1, 4, 9 Qian Y....Shen H.B. (Zhonghua Yu Fang Yi Xue Za Zhi 2010)
    161. Polymorphisms of XRCC1 gene and risk of gastric cardiac adenocarcinoma. (PubMed id 19673050)1, 4, 9 Yan L....Zhifeng C. (Dis. Esophagus 2009)
    162. Prognostic significance of X-ray cross-complementing group 1 T-77C polymorphism in resected non-small cell lung cancer. (PubMed id 19052039)1, 4, 9 Hsieh W.C....Lee H. (Jpn. J. Clin. Oncol. 2009)
    163. DNA repair gene XRCC1 polymorphisms and outcome of renal cell carcinoma in Caucasian patients. (PubMed id 20044627)1, 4, 9 Bachmann H.S....Riemann K. (Anticancer Res. 2009)
    164. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. (PubMed id 19174490)1, 4, 9 Cote M.L....Schwartz A.G. (Carcinogenesis 2009)
    165. Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie. (PubMed id 19332728)1, 4, 9 Goekkurt E....Stoehlmacher J. (J. Clin. Oncol. 2009)
    166. Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms. (PubMed id 19177501)1, 4, 9 CatalA!n J....Norppa H. (Environ. Mol. Mutagen. 2009)
    167. Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai. (PubMed id 19350405)1, 4, 9 Wen H....Fang J. (Int Urol Nephrol 2009)
    168. Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer. (PubMed id 19959686)1, 4, 9 Curtin K....Slattery M.L. (amp 2009)
    169. Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial. (PubMed id 19858398)1, 4, 9 Braun M.S....Seymour M.T. (J. Clin. Oncol. 2009)
    170. Genetic polymorphisms in DNA repair genes as modulators of Hodgkin disease risk. (PubMed id 19280628)1, 4, 9 El-Zein R....Strom S.S. (Cancer 2009)
    171. Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia. (PubMed id 19162321)1, 4, 9 da Silva Silveira V....Tone L.G. (Leuk. Res. 2009)
    172. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PubMed id 19116388)1, 4, 9 Vineis P....Matullo G. (J. Natl. Cancer Inst. 2009)
    173. Gastric cardia carcinoma is associated with the promoter -77T&gt;C gene polymorphism of X-ray cross-complementing group 1 (XRCC1). (PubMed id 19662459)1, 4, 9 Corso G....Roviello F. (J. Gastrointest. Surg. 2009)
    174. Haplotypes of microsomal epoxide hydrolase and x-ray cross-complementing group 1 genes in Indian hepatocellular carcinoma patients. (PubMed id 19754350)1, 4, 9 Kiran M....Kaur J. (DNA Cell Biol. 2009)
    175. DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer. (PubMed id 19362955)1, 4, 9 Kalikaki A....Mavroudis D. (Clin Lung Cancer 2009)
    176. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. (PubMed id 19286843)1, 4, 9 Akulevich N.M....Yamashita S. (Endocr. Relat. Cancer 2009)
    177. XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia. (PubMed id 20013659)1, 4, 9 Meza-Espinoza J.P....Leal-Ugarte E. (Genet. Mol. Res. 2009)
    178. Genetic polymorphisms and expression of minisatellite mutations in a 3-generation population around the Semipalatinsk nuclear explosion test-site, Kazakhstan. (PubMed id 19656722)1, 4, 9 Bolegenova N.K....Au W.W. (Int J Hyg Environ Health 2009)
    179. Effects of cigarette smoking, XRCC1 genetic polymorphisms, and age on basal DNA damage in human blood mononuclear cells. (PubMed id 19628051)1, 4, 9 Weng H....Morimoto K. (Mutat. Res. 2009)
    180. Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck. (PubMed id 19284666)1, 4, 9 Kowalski M....Majsterek I. (amp 2009)
    181. Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. (PubMed id 19061777)1, 4, 9 Yin J....Wang H. (Cancer Genet. Cytogenet. 2009)
    182. Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan. (PubMed id 19604089)1, 4, 9 Hoskins J.M....Innocenti F. (Pharmacogenomics 2009)
    183. Single-nucleotide polymorphisms of DNA repair genes OGG1 and XRCC1: association with gallbladder cancer in North Indian population. (PubMed id 19266243)1, 4, 9 Srivastava A....Mittal B. (Ann. Surg. Oncol. 2009)
    184. hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease. (PubMed id 19493423)1, 4, 9 Yang S.F....Zhang Z.X. (Chin. Med. J. 2009)
    185. Role of DNA repair systems in malignant tumor development in the elderly. (PubMed id 18713157)1, 4, 9 Arai T....Tanaka N. (amp 2008)
    186. Case-only study of interactions between DNA repair genes (hMLH1, APEX1, MGMT, XRCC1 and XPD) and low-frequency electromagnetic fields in childhood acute leukemia. (PubMed id 19052983)1, 4, 9 Yang Y....Shen X. (amp 2008)
    187. International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. (PubMed id 18990748)1, 4, 9 Hung R.J....Brennan P. (amp 2008)
    188. Efficiency of the DNA repair and polymorphisms of the XRCC1, XRCC3 and XRCC4 DNA repair genes in systemic lupus erythematosus. (PubMed id 18852222)1, 4, 9 Bassi C....Donadi E. (Lupus 2008)
    189. [Association of the XRCC1 and hOGG1 polymorphisms with the risk of laryngeal carcinoma]. (PubMed id 18393249)1, 4, 9 Yang Y....Zhang Z.J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    190. [The evaluation of association between polymorphisms of DNA excision repair enzyme genes and risk of malignant tumors development in Siberian Group of Chemical Enterprises workers]. (PubMed id 18825991)1, 4, 9 FreA-din M.B....Karpov A.B. (Radiats Biol Radioecol 2008)
    191. A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk. (PubMed id 18765423)1, 4, 9 Lao T....Huang Q. (Mutagenesis 2008)
    192. Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy. (PubMed id 18797464)1, 4, 9 ParAc L....Baiget M. (Br. J. Cancer 2008)
    193. No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study. (PubMed id 18349297)1, 4, 9 Ferguson H.R....Hardie L.J. (amp 2008)
    194. Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery. (PubMed id 18214807)1, 4, 9 Kim Y.J....Chung H.W. (J. Toxicol. Environ. Health Part A 2008)
    195. The investigation of DNA repair polymorphisms with histopathological characteristics and hormone receptors in a group of Brazilian women with breast cancer. (PubMed id 18752184)1, 4, 9 Dufloth R.M....Zeferino L.C. (Genet. Mol. Res. 2008)
    196. Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus. (PubMed id 18188695)1, 4, 9 Loizidou M.A....Hadjisavvas A. (Breast Cancer Res. Treat. 2008)
    197. Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population. (PubMed id 19031937)1, 4, 9 Improta G....Cittadini A. (Anticancer Res. 2008)
    198. Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy. (PubMed id 18829510)1, 4, 9 Azria D....Rosenstein B.S. (Clin. Cancer Res. 2008)
    199. Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease. (PubMed id 18672023)1, 4, 9 Parildar-KarpuzoA9lu H....Uysal M. (Neurosci. Lett. 2008)
    200. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. (PubMed id 18544627)1, 4, 9 McWilliams R.R....Petersen G.M. (Cancer Res. 2008)
    201. Prevalence of BER gene polymorphisms in sporadic breast cancer. (PubMed id 18357393)1, 4, 9 Ali M.F....Chakravarti D. (Oncol. Rep. 2008)
    202. Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer. (PubMed id 17925548)1, 4, 9 Marsh S....Brown R. (J. Clin. Oncol. 2007)
    203. A pharmacogenomic study of docetaxel and gemcitabine for the initial treatment of advanced non-small cell lung cancer. (PubMed id 17410042)1, 4, 9 Petty W.J....Miller A.A. (J Thorac Oncol 2007)
    204. Polymorphisms of DNA repair genes are risk factors for prostate cancer. (PubMed id 17196815)1, 4, 9 Hirata H....Dahiya R. (Eur. J. Cancer 2007)
    205. Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan. (PubMed id 17273745)1, 4, 9 Martinez-Balibrea E....Abad A. (Oncol. Rep. 2007)
    206. Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer. (PubMed id 17504986)1, 4, 9 Giachino D.F....Scagliotti G.V. (Clin. Cancer Res. 2007)
    207. A prospective study of polymorphisms of DNA repair genes XRCC1, XPD23 and APE/ref-1 and risk of stroke in Linxian, China. (PubMed id 17630376)1, 4, 9 Mahabir S....Mark S.D. (J Epidemiol Community Health 2007)
    208. The DNA repair gene XRCC1 and genetic susceptibility of lung cancer in a northeastern Chinese population. (PubMed id 17316890)1, 4, 9 Yin J....Wang H. (Lung Cancer 2007)
    209. [Association between genetic polymorphisms of DNA repair genes XRCC1, XPD, XRCC3 and the capacity of DNA repair induce by benzene]. (PubMed id 18095557)1, 4, 9 Xu J....Wang Q. (Wei Sheng Yan Jiu 2007)
    210. PAH-DNA adducts in environmentally exposed population in relation to metabolic and DNA repair gene polymorphisms. (PubMed id 17412371)1, 4, 9 Binkova B....Sram R.J. (Mutat. Res. 2007)
    211. Genetic polymorphisms of the DNA repair gene and risk of nasopharyngeal carcinoma. (PubMed id 17630853)1, 4, 9 Yang Z.H....Zhang L. (DNA Cell Biol. 2007)
    212. APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. (PubMed id 17353262)1, 2, 9 Iles N.... Caldecott K.W. (Mol. Cell. Biol. 2007)
    213. The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease. (PubMed id 17385092)1, 4, 9 DoA9ru-AbbasoA9lu S....Uysal M. (Neurol. Sci. 2007)
    214. The nonsynonymous single nucleotide polymorphisms of DNA repair gene XRCC1 and susceptibility to the development of cervical carcinoma and high-risk human papillomavirus infection. (PubMed id 17504380)1, 4, 9 Huang J....Xie X. (Int. J. Gynecol. Cancer 2007)
    215. X-ray repair cross-complementing group 1 (XRCC1) single-nucleotide polymorphisms and the risk of salivary gland carcinomas. (PubMed id 17559126)1, 4, 9 Ho T....Sturgis E.M. (Cancer 2007)
    216. Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. (PubMed id 17593927)1, 4, 9 Liu B....Yu L. (Eur. J. Hum. Genet. 2007)
    217. Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials. (PubMed id 17197435)1, 4, 9 Kuptsova N....Ambrosone C.B. (Blood 2007)
    218. Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. (PubMed id 17191090)1, 4, 9 Yeh C.C....Hsieh L.L. (J. Biomed. Sci. 2007)
    219. Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma. (PubMed id 16639733)1, 4, 9 Cai L....Zhang Z.F. (Cancer 2006)
    220. Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer. (PubMed id 16492928)1, 4, 9 Zhang Y....Garcia-Closas M. (amp 2006)
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    222. Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency. (PubMed id 17078101)1, 4, 9 Laczmanska I....Sasiadek M.M. (Environ. Mol. Mutagen. 2006)
    223. Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population. (PubMed id 16796765)1, 4, 9 Cao Y....Shao J.Y. (BMC Cancer 2006)
    224. Polymorphisms of DNA repair genes are associated with renal cell carcinoma. (PubMed id 16510122)1, 4, 9 Hirata H....Dahiya R. (Biochem. Biophys. Res. Commun. 2006)
    225. Genetic polymorphisms and possible gene-gene interactions in metabolic and DNA repair genes: effects on DNA damage. (PubMed id 16043197)1, 4, 9 Naccarati A....Vodicka P. (Mutat. Res. 2006)
    226. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. (PubMed id 16652158)1, 4, 9 Hao B....He F. (Oncogene 2006)
    227. XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer. (PubMed id 16875718)1, 4, 9 Chung H.H....Lee H.P. (Gynecol. Oncol. 2006)
    228. Polymorphisms in DNA repair genes XPD and XRCC1 and p53 mutations in lung carcinomas of never-smokers. (PubMed id 16865671)1, 4, 9 Gao W.M....Keohavong P. (Mol. Carcinog. 2006)
    229. Pharmacogenetic profiling and clinical outcome of patients with advanced gastric cancer treated with palliative chemotherapy. (PubMed id 16622263)1, 4, 9 Ruzzo A....Magnani M. (J. Clin. Oncol. 2006)
    230. Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to cytostatics. (PubMed id 17159780)1, 4, 9 MusA!k L....PAcc M. (Neuro Endocrinol. Lett. 2006)
    231. DNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish population. (PubMed id 17214369)1, 4, 9 Karahalil B....OzAselik T. (Anticancer Res. 2006)
    232. The XRCC1 -77T-&gt;C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage. (PubMed id 16829685)1, 4, 9 Brem R....Hall J. (Carcinogenesis 2006)
    233. Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. (PubMed id 16609022)1, 4, 9 Moreno V....Canzian F. (Clin. Cancer Res. 2006)
    234. Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples. (PubMed id 16966185)1, 4, 9 Andreassen C.N....Overgaard J. (Int. J. Radiat. Biol. 2006)
    235. Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer. (PubMed id 17116943)1, 4, 9 Bewick M.A....Lafrenie R.M. (J. Clin. Oncol. 2006)
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    237. Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. (PubMed id 16638864)1, 4, 9 Damaraju S....Parliament M. (Clin. Cancer Res. 2006)
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    239. Influence of polymorphisms in DNA repair genes XPD, XRCC1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro. (PubMed id 16038584)1, 4, 9 Rzeszowska-Wolny J....Hancock R. (Radiat. Res. 2005)
    240. DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia. (PubMed id 15596292)1, 4, 9 Joseph T....Pillai M.R. (Cancer Lett. 2005)
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    242. Impact of gene polymorphisms on clinical outcome for stage IV melanoma patients treated with biochemotherapy: an exploratory study. (PubMed id 15709194)1, 4, 9 Liu D....Weber J. (Clin. Cancer Res. 2005)
    243. Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. (PubMed id 16157195)1, 4, 9 Chan E.C....Kwong Y.L. (Cancer Genet. Cytogenet. 2005)
    244. Risk assessment of welders using analysis of eight metals by ICP-MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays; influence of XRCC1 and XRCC3 polymorphisms. (PubMed id 16234265)1, 4, 9 Iarmarcovai G....Botta A. (Mutagenesis 2005)
    245. A promoter polymorphism (-77T&gt;C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking. (PubMed id 15970793)1, 4, 9 Hu Z....Shen H. (Pharmacogenet. Genomics 2005)
    246. Genotyping of patients with sporadic and radiation-associated meningiomas. (PubMed id 15824172)1, 4, 9 Sadetzki S....Friedman E. (amp 2005)
    247. Glutathione S-transferase polymorphisms and survival from head and neck cancer. (PubMed id 15668931)1, 4, 9 Geisler S.A....Bell D. (amp 2005)
    248. XRCC1 polymorphism and lung cancer risk in relation to tobacco smoking. (PubMed id 16142409)1, 4, 9 Schneider J....Philipp M. (Int. J. Mol. Med. 2005)
    249. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. (PubMed id 15746160)1, 4, 9 Broberg K....Albin M. (Carcinogenesis 2005)
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    252. A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. (PubMed id 15213713)1, 4, 9 Stoehlmacher J....Lenz H.J. (Br. J. Cancer 2004)
    253. Association of DNA repair gene XRCC1 polymorphisms with head and neck cancer in Korean population. (PubMed id 15252855)1, 4, 9 Tae K....Shin H.D. (Int. J. Cancer 2004)
    254. Genetic variation in XRCC1, sun exposure, and risk of skin cancer. (PubMed id 15381933)1, 4, 9 Han J....Hunter D.J. (Br. J. Cancer 2004)
    255. Genetic polymorphisms in the Hmong population: implications for cancer etiology and survival. (PubMed id 14716779)1, 4, 9 Kiffmeyer W.R....Ross J.A. (Cancer 2004)
    256. XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin disease. (PubMed id 15368334)1, 4, 9 Mertens A.C....Davies S.M. (Cancer 2004)
    257. No association between base excision repair gene polymorphisms and risk of lung cancer. (PubMed id 15587988)1, 4, 9 Vogel U....Raaschou-Nielsen O. (Biochem. Genet. 2004)
    258. Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer. (PubMed id 15533591)1, 4, 9 Ratnasinghe L.D....Taylor P.R. (Cancer Lett. 2004)
    259. Single nucleotide polymorphisms in breast cancer. (PubMed id 15010895)1, 4, 9 FAPrsti A....Kumar R. (Oncol. Rep. 2004)
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    261. Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk. (PubMed id 15066914)1, 4, 9 Han J....Hunter D.J. (amp 2004)
    262. Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers. (PubMed id 15468052)1, 4, 9 Godderis L....Lison D. (Environ. Mol. Mutagen. 2004)
    263. CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx. (PubMed id 14639127)1, 4, 9 Varzim G....Lopes C. (Eur. J. Cancer Prev. 2003)
    264. Irinotecan pathway genotype analysis to predict pharmacokinetics. (PubMed id 12960109)1, 4, 9 Mathijssen R.H....McLeod H.L. (Clin. Cancer Res. 2003)
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    267. Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes. (PubMed id 14625810)1, 4, 9 Mathonnet G....Sinnett D. (J. Hum. Genet. 2003)
    268. DNA-repair genetic polymorphisms and breast cancer risk. (PubMed id 14652281)1, 4, 9 Smith T.R....Hu J.J. (amp 2003)
    269. A population-based case-control study of the Arg399Gln polymorphism in DNA repair gene XRCC1 and risk of breast cancer. (PubMed id 14693738)1, 4, 9 Shu X.O....Zheng W. (amp 2003)
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    272. Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer. (PubMed id 11815397)1, 4, 9 Park J.Y....Jung T.H. (amp 2002)
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    274. DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk. (PubMed id 12223443)1, 4, 9 Stern M.C....Taylor J.A. (amp 2002)
    275. Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia. (PubMed id 11895912)1, 4, 9 Krajinovic M....Sinnett D. (Clin. Cancer Res. 2002)
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    279. A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer. (PubMed id 11712813)1, 4, 9 Stoehlmacher J....Lenz H.J. (Anticancer Res. 2001)
    280. The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung. (PubMed id 11104903)1, 4, 9 Divine K.K....Belinsky S.A. (Mutat. Res. 2001)
    281. XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects. (PubMed id 11532866)1, 4, 9 Matullo G....Vineis P. (Carcinogenesis 2001)
    282. BER gene polymorphisms (OGG1 Ser326Cys and XRCC1 Arg194Trp) and modulation of DNA damage due to pesticides exposure. (PubMed id 20209647)1, 4 Rohr P....Kvitko K. (Environ. Mol. Mutagen. 2011)
    283. Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia. (PubMed id 20232390)1, 4 Shi J.Y....Chen S.J. (Int. J. Cancer 2011)
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    285. Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis. (PubMed id 21234761)1, 4 Tahara T....Arisawa T. (Virchows Arch. 2011)
    286. Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer. (PubMed id 20477822)1, 4 Abe M....Chan J.M. (BJU Int. 2011)
    287. The association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia. (PubMed id 20364408)1, 4 Stanczyk M....Majsterek I. (Mol. Biol. Rep. 2011)
    288. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)
    289. DNA repair gene polymorphisms and prostate cancer risk in South Australia--results of a pilot study. (PubMed id 19914098)1, 4 Dhillon V.S....Fenech M. (Urol. Oncol. 2011)
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    291. DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia. (PubMed id 20394984)1, 4 Tumer T.B....ArinAs E. (Leuk. Res. 2010)
    292. Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis. (PubMed id 19707910)1, 4 CoppedA" F....Migliore L. (Amyotroph Lateral Scler 2010)
    293. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    294. Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese. (PubMed id 20553853)1, 4 Qian Y....Guo L. (J. Neurol. Sci. 2010)
    295. Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms. (PubMed id 20723587)1, 4 Bagryantseva Y....Sram R.J. (Toxicol. Lett. 2010)
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    302. XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. (PubMed id 20577654)1, 4 Chen P.L....Cheng Y.W. (Mol. Vis. 2010)
    303. Genotoxicity surveillance programme in workers dismantling World War I chemical ammunition. (PubMed id 20306073)1, 4 Mateuca R.A....Kirsch-Volders M. (Int Arch Occup Environ Health 2010)
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    305. Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. (PubMed id 20610542)1, 4 Liu Y....Bondy M.L. (Carcinogenesis 2010)
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    309. Assessment of occupational cytogenetic risk, among petrol station workers. (PubMed id 20652227)1, 4 Bindhya S....Sasikala K. (Bull Environ Contam Toxicol 2010)
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    312. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
    313. Joint effects of XRCC1 polymorphisms and polycyclic aromatic hydrocarbons exposure on sperm DNA damage and male infertility. (PubMed id 20395310)1, 4 Ji G....Wang X. (Toxicol. Sci. 2010)
    314. Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. (PubMed id 20511665)1, 4 Vijayakrishnan J. and Houlston R.S. (Haematologica 2010)
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    318. Additive effects of genetic variations of xenobiotic detoxification enzymes and DNA repair gene XRCC1 on the susceptibility to breast cancer. (PubMed id 19731014)1, 4 Masoudi M....Saadat M. (Breast Cancer Res. Treat. 2010)
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    320. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. (PubMed id 20150366)1, 4 Rajaraman P....Inskip P.D. (Neuro-oncology 2010)
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    325. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
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    328. Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. (PubMed id 20170971)1, 4 Zschenker O....Borgmann K. (Radiother Oncol 2010)
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    331. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
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    333. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PubMed id 20226869)1, 4 Thyagarajan B....Arora M. (Biol. Blood Marrow Transplant. 2010)
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    335. A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens. (PubMed id 20802378)1, 4 Horn H....Schaeffeler E. (Pharmacogenet. Genomics 2010)
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    338. Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum compounds: a Korean population-based study. (PubMed id 19203783)1, 4 Kim H.S....Kang S.B. (Gynecol. Oncol. 2009)
    339. Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. (PubMed id 19661089)1, 4 Hussain S.K....Zhang Z.F. (amp 2009)
    340. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. (PubMed id 19012493)1, 4 Wang S.S....Hildesheim A. (J. Infect. Dis. 2009)
    341. Gene-environment interactions between DNA repair polymorphisms and exposure to the carcinogen vinyl chloride. (PubMed id 19274602)1, 4 Li Y....Brandt-Rauf P.W. (Biomarkers 2009)
    342. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    343. Association and interactions between DNA repair gene polymorphisms and adult glioma. (PubMed id 19124499)1, 4 Liu Y....Bondy M.L. (amp 2009)
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    346. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    347. DNA repair gene variants associated with benign breast disease in high cancer risk women. (PubMed id 19124519)1, 4 Jorgensen T.J....Visvanathan K. (amp 2009)
    348. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    349. XRCC1 Arg194Trp polymorphism and risk of chronic obstructive pulmonary disease. (PubMed id 19821085)1, 4 Xie J....Zhang Z. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2009)
    350. Chromosome aberrations in workers exposed to organic solvents: Influence of polymorphisms in xenobiotic-metabolism and DNA repair genes. (PubMed id 19481674)1, 4 Hoyos-Giraldo L.S....SA!nchez-GA^mez A. (Mutat. Res. 2009)
    351. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    352. DNA repair gene XRCC1 polymorphisms and non-Hodgkin lymphoma risk in a Chinese population. (PubMed id 19446740)1, 4 Liu J....Han J. (Cancer Genet. Cytogenet. 2009)
    353. Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer. (PubMed id 19367277)1, 4 Chang-Claude J....Popanda O. (Br. J. Cancer 2009)
    354. Analysis and estimates of the attributable risk for environmental and genetic risk factors in gastric cancer in a Chinese population. (PubMed id 19492240)1, 4 Shen X....Pu Y. (J. Toxicol. Environ. Health Part A 2009)
    355. Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. (PubMed id 18830263)1, 4 Wang S.S....Cerhan J.R. (Leukemia 2009)
    356. Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population. (PubMed id 19147860)1, 4 Li W.Q....You W.C. (Carcinogenesis 2009)
    357. XRCC1399 and hOGG1326 polymorphisms and frequencies of micronuclei, comet and chromosomal aberrations among tobacco chewers: a South Indian population study. (PubMed id 20192583)1, 4 Sellappa S....Sasikala K. (Asian Pac. J. Cancer Prev. 2009)
    358. Polymorphism of DNA repair gene XRCC1 and hepatitis-related hepatocellular carcinoma risk in Indian population. (PubMed id 19194663)1, 4 Kiran M....Kaur J. (Mol. Cell. Biochem. 2009)
    359. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    360. Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population. (PubMed id 19880550)1, 4 Lin Y.J....Tsai F.J. (Lupus 2009)
    361. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    362. Suboptimal DNA repair capacity predisposes coke-oven workers to accumulate more chromosomal damages in peripheral lymphocytes. (PubMed id 19240242)1, 4 Cheng J....Zheng Y. (amp 2009)
    363. Cytochrome P450 2E1 and head and neck cancer: interaction with genetic and environmental risk factors. (PubMed id 19334053)1, 4 Ruwali M....Parmar D. (Environ. Mol. Mutagen. 2009)
    364. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. (PubMed id 19679847)1, 4 Lanktree M.B....Anand S.S. ( a journal of cerebral circulation 2009)
    365. Single nucleotide polymorphisms in DNA repair genes XRCC1 and APEX1 in progression and survival of primary cutaneous melanoma patients. (PubMed id 19073198)1, 4 Figl A....Schadendorf D. (Mutat. Res. 2009)
    366. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    367. Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis. (PubMed id 19191745)1, 4 Ho T....Sturgis E.M. (Thyroid 2009)
    368. Pharmacogenetic analyses of hematotoxicity in advanced gastric cancer patients receiving biweekly fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). (PubMed id 19074750)1, 4 Goekkurt E....Stoehlmacher J. (Ann. Oncol. 2009)
    369. Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. (PubMed id 19826048)1, 4 Akbari M.R....Narod S.A. (Cancer Res. 2009)
    370. Racial differences in advanced colorectal cancer outcomes and pharmacogenetics: a subgroup analysis of a large randomized clinical trial. (PubMed id 19636001)1, 4 Sanoff H.K....Goldberg R.M. (J. Clin. Oncol. 2009)
    371. Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans. (PubMed id 19029194)1, 4 Chang J.S....Wiencke J.K. (Carcinogenesis 2009)
    372. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)1, 4 Kweekel D.M....Guchelaar H.J. (Br. J. Cancer 2009)
    373. Influence of DNA repair gene polymorphisms on the initial repair of MMS-induced DNA damage in human lymphocytes as measured by the alkaline comet assay. (PubMed id 18627000)1, 4 Ryk C....Hou S. (Environ. Mol. Mutagen. 2008)
    374. XRCC1 and XRCC3 variants and risk of glioma and meningioma. (PubMed id 18330515)1, 4 Kiuru A....Auvinen A. (J. Neurooncol. 2008)
    375. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    376. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    377. Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. (PubMed id 18701435)1, 4 Smith T.R....Hu J.J. (Carcinogenesis 2008)
    378. XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine polymorphisms are associated with response to platinum-based neoadjuvant chemotherapy in cervical cancer. (PubMed id 18851872)1, 4 Kim K....Song Y.S. (Gynecol. Oncol. 2008)
    379. Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to chromium. (PubMed id 18987609)1, 4 Halasova E....Vodicka P. (Neuro Endocrinol. Lett. 2008)
    380. Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer. (PubMed id 18448328)1, 4 Martinez-Balibrea E....Guino E. (Eur. J. Cancer 2008)
    381. The polymorphism of XRCC3 codon 241 and AFB1-related hepatocellular carcinoma in Guangxi population, China. (PubMed id 18504145)1, 4 Long X.D....Zhou S.C. (Ann Epidemiol 2008)
    382. Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair. (PubMed id 18569591)1, 4 Harth V....Ickstadt K. (J. Toxicol. Environ. Health Part A 2008)
    383. Irinotecan pharmacogenetics: influence of pharmacodynamic genes. (PubMed id 18347181)1, 4 Hoskins J.M....Baiget M. (Clin. Cancer Res. 2008)
    384. Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk. (PubMed id 18478337)1, 4 Tse D....Liu G. (amp 2008)
    385. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    386. Polymorphisms and haplotypes of DNA repair and xenobiotic metabolism genes and risk of DNA damage in Chinese vinyl chloride monomer (VCM)-exposed workers. (PubMed id 18420361)1, 4 Zhu S.M....Christiani D.C. (Toxicol. Lett. 2008)
    387. Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study. (PubMed id 18365755)1, 4 Covolo L....Porru S. (Eur. J. Epidemiol. 2008)
    388. Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan. (PubMed id 18410587)1, 4 Yen C.Y....Chang H.W. (amp 2008)
    389. DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy. (PubMed id 17898541)1, 4 Andrew A.S....Matullo G. (Hum. Hered. 2008)
    390. Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker. (PubMed id 18505590)1, 4 Keam B....Bang Y.J. (BMC Cancer 2008)
    391. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. (PubMed id 18641418)1, 4 CapellA! G....GonzA!lez C.A. (Int J Epidemiol 2008)
    392. SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan. (PubMed id 18199464)1, 4 Hsu L.I....Chen C.J. (Toxicol. Appl. Pharmacol. 2008)
    393. Ethnic disparities in Americans of European descent versus Americans of African descent related to polymorphic ERCC1, ERCC2, XRCC1, and PARP1. (PubMed id 18483312)1, 4 Gao R....Figg W.D. (Mol. Cancer Ther. 2008)
    394. Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy. (PubMed id 17549067)1, 4 Ruzzo A....Magnani M. (Pharmacogenomics J. 2008)
    395. Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. (PubMed id 18509181)1, 4 Braun M.S....Seymour M.T. (J. Clin. Oncol. 2008)
    396. Haplotypes of nine single nucleotide polymorphisms on chromosome 19q13.2-3 associated with susceptibility of lung cancer in a Chinese population. (PubMed id 18358500)1, 4 Yin J....Wang H. (Mutat. Res. 2008)
    397. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)
    398. Effects of the XRCC1 gene-environment interactions on DNA damage in healthy Japanese workers. (PubMed id 18800344)1, 4 Weng Z....Morimoto K. (Environ. Mol. Mutagen. 2008)
    399. Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma. (PubMed id 18386788)1, 4 Doecke J....Whiteman D.C. (Int. J. Cancer 2008)
    400. DNA repair gene polymorphisms may be associated with prognosis of upper urinary tract transitional cell carcinoma. (PubMed id 18320070)1, 4 Sasaki M....Naito K. (Neoplasia 2008)
    401. Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population. (PubMed id 18823566)1, 4 Kasahara M....Takahashi J. (amp 2008)
    402. Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China. (PubMed id 17984110)1, 4 Huang W.Y....Hsing A.W. (Carcinogenesis 2008)
    403. ERCC2 2251A&gt;C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. (PubMed id 18267032)1, 4 Huang M.Y....Lin S.R. (BMC Cancer 2008)
    404. Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy. (PubMed id 17401013)1, 4 Ruzzo A....Magnani M. (J. Clin. Oncol. 2007)
    405. XRCC1 codon 399 and ERCC2 codon 751 polymorphism, smoking, and drinking and risk of esophageal squamous cell carcinoma in a North Indian population. (PubMed id 17556064)1, 4 Sobti R.C....Bindra H.S. (Cancer Genet. Cytogenet. 2007)
    406. DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population. (PubMed id 17063276)1, 4 Costa S....Schmitt F. (Breast Cancer Res. Treat. 2007)
    407. Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies. (PubMed id 17476281)1, 4 Guillem V.M....Tormo M. (Leukemia 2007)
    408. Polymorphisms in the DNA repair gene XRCC1 associated with basal cell carcinoma and squamous cell carcinoma of the skin in a Korean population. (PubMed id 17355263)1, 4 Kang S.Y....Kim N.K. (Cancer Sci. 2007)
    409. Lack of association of XRCC1 codon 399Gln polymorphism with chronic myelogenous leukemia. (PubMed id 17695538)1, 4 Deligezer U....Dalay N. (Anticancer Res. 2007)
    410. High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. (PubMed id 17220334)1, 4 Huang M....Wu X. (amp 2007)
    411. The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma. (PubMed id 17712032)1, 4 Sakano S....Naito K. (Ann. Oncol. 2007)
    412. Polymorphisms of DNA repair genes XPD and XRCC1 and risk of cataract development. (PubMed id 17637462)1, 4 Unal M....DevranoA9lu K. (Exp. Eye Res. 2007)
    413. [Relationship between DNA repair gene XRCC1 Arg399Gln polymorphism and susceptibility to prostate cancer in the Han population in Jiangsu and Anhui]. (PubMed id 17491266)1, 4 Xu Z....Wu H.F. (Zhonghua Nan Ke Xue 2007)
    414. DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. (PubMed id 18006925)1, 4 Stern M.C....Yu M.C. (amp 2007)
    415. Genetic variation in the base excision repair pathway and bladder cancer risk. (PubMed id 17203305)1, 4 Figueroa J.D....GarcA-a-Closas M. (Hum. Genet. 2007)
    416. Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG). (PubMed id 17242676)1, 4 GA1ven M....Sarici A. (Mol. Vis. 2007)
    417. Path analysis of biomarkers of exposure and early biological effects among coke-oven workers exposed to polycyclic aromatic hydrocarbons. (PubMed id 17548684)1, 4 Qiu L....Wang Z. (amp 2007)
    418. Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions. (PubMed id 16956909)1, 4 Manuguerra M....Vineis P. (Carcinogenesis 2007)
    419. Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer. (PubMed id 17558308)1, 4 Jaremko M....Brauch H. (Pharmacogenet. Genomics 2007)
    420. Polymorphism of XRCC1 codon arg 399 Gln is associated with higher susceptibility to endometriosis. (PubMed id 18442016)1, 4 Bau D.T....Tsai F.J. (Chin J Physiol 2007)
    421. DNA repair gene XRCC1 and XPD polymorphisms and their association with coronary artery disease risks and micronucleus frequency. (PubMed id 18043991)1, 4 Guven M....Domanic N. (Heart Vessels 2007)
    422. Effects of base excision repair gene polymorphisms on pancreatic cancer survival. (PubMed id 17230526)1, 4 Li D....Abbruzzese J.L. (Int. J. Cancer 2007)
    423. Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. (PubMed id 17531525)1, 4 De Ruyck K....Thierens H. (Mutat. Res. 2007)
    424. [Association between genetic polymorphisms of DNA repair genes XRCC1, XRCC3 and susceptibility to chronic benzene poisoning]. (PubMed id 17535647)1, 4 Huang H.L....Li G.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2007)
    425. Genetic polymorphisms of DNA repair gene: XRCC1 Pro206Pro and Gln632Gln in a Chinese Han population. (PubMed id 17939032)1, 4 Yin J....Wang H. (Biochem. Genet. 2007)
    426. Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects. (PubMed id 17028303)1, 4 Vodicka P....Hemminki K. (Carcinogenesis 2007)
    427. Polymorphisms in XPD, XPC and the risk of death in patients with urinary bladder neoplasms. (PubMed id 17438703)1, 4 Sanyal S....Kumar R. (Acta Oncol 2007)
    428. Association of XRCC1 gene polymorphisms with idiopathic azoospermia in a Chinese population. (PubMed id 17968463)1, 4 Gu A.H....Wang X.R. (Asian J. Androl. 2007)
    429. Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes. (PubMed id 17374727)1, 4 Breton C.V....Christiani D.C. (Carcinogenesis 2007)
    430. Genetic susceptibility of newborn daughters to oxidative stress. (PubMed id 17614221)1, 4 Decordier I....Kirsch-Volders M. (Toxicol. Lett. 2007)
    431. Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma. (PubMed id 17283177)1, 4 Berndt S.I....Hayes R.B. (Cancer Res. 2007)
    432. Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. (PubMed id 17290401)1, 4 Majumder M....Roy B. (Int. J. Cancer 2007)
    433. Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer. (PubMed id 16785472)1, 4 Wu X....Ajani J.A. (J. Clin. Oncol. 2006)
    434. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. (PubMed id 16520463)1, 4 Li D....Abbruzzese J.L. (J. Clin. Oncol. 2006)
    435. Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis. (PubMed id 16328064)1, 4 Zhai X....Shen H. (Oncol. Rep. 2006)
    436. Association between DNA repair gene polymorphisms and p53 alterations in Japanese patients with muscle-invasive bladder cancer. (PubMed id 17374967)1, 4 Sakano S....Naito K. (Pathobiology 2006)
    437. Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium. (PubMed id 17018785)1, 4 (J. Natl. Cancer Inst. 2006)
    438. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. (PubMed id 16308313)1, 4 Matullo G....Vineis P. (Carcinogenesis 2006)
    439. A phase II study of irinotecan and carboplatin in advanced non-small cell lung cancer with pharmacogenomic analysis: final report. (PubMed id 17409981)1, 4 Pillot G.A....Govindan R. (J Thorac Oncol 2006)
    440. No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study. (PubMed id 16963196)1, 4 Thyagarajan B....Gross M.D. (Cancer Detect. Prev. 2006)
    441. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. (PubMed id 16311243)1, 4 Andrew A.S....Karagas M.R. (Carcinogenesis 2006)
    442. Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer. (PubMed id 16324877)1, 4 Ramachandran S....Radhakrishna Pillai M. (Oral Oncol. 2006)
    443. Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. (PubMed id 16373199)1, 4 Kietthubthew S....Ishida T. (Int J Hyg Environ Health 2006)
    444. Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs. (PubMed id 16395669)1, 4 Gaustadnes M....Torring N. (Hum. Mutat. 2006)
    445. Multiplex pyrosequencing of two polymorphisms in DNA repair gene XRCC1. (PubMed id 16931584)1, 4 van der Straaten T....Guchelaar H.J. (J Mol Diagn 2006)
    446. DNA-repair gene polymorphisms predict favorable clinical outcome among patients with advanced squamous cell carcinoma of the head and neck treated with cisplatin-based induction chemotherapy. (PubMed id 16896002)1, 4 Quintela-Fandino M....Sanchez-Cespedes M. (J. Clin. Oncol. 2006)
    447. Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. (PubMed id 16844323)1, 4 Jiao L....Li D. (Cancer Detect. Prev. 2006)
    448. Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients. (PubMed id 16407418)1, 4 de las PeA+as R....Rosell R. (Ann. Oncol. 2006)
    449. Polymorphisms in DNA repair genes as risk factors for asbestos-related malignant mesothelioma in a general population study. (PubMed id 16564556)1, 4 Dianzani I....Magnani C. (Mutat. Res. 2006)
    450. Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis. (PubMed id 16982113)1, 4 Kiyohara C....Nakanishi Y. (Lung Cancer 2006)
    451. Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk. (PubMed id 16569655)1, 4 Nock N.L....Witte J.S. (Carcinogenesis 2006)
    452. [Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury]. (PubMed id 16978516)1, 4 Wang L.Q....Li R.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2006)
    453. Single nucleotide polymorphisms in DNA repair genes might be prognostic factors in muscle-invasive bladder cancer patients treated with chemoradiotherapy. (PubMed id 16880786)1, 4 Sakano S....Naito K. (Br. J. Cancer 2006)
    454. Association between polymorphisms of DNA repair gene XRCC1 and DNA damage in asbestos-exposed workers. (PubMed id 16944782)1, 4 Zhao X.H....Liu N. (Biomed. Environ. Sci. 2006)
    455. Possible association of the X-ray cross complementing gene 1 (XRCC1) Arg280His polymorphism as a risk for rheumatoid arthritis. (PubMed id 16284769)1, 4 Koyama A....Horiuchi S. (Rheumatol. Int. 2006)
    456. Influence of DNA repair polymorphisms on biomarkers of genotoxic damage in peripheral lymphocytes of healthy subjects. (PubMed id 16824555)1, 4 Zijno A....Crebelli R. (Mutat. Res. 2006)
    457. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    458. Lycopene intake and prostate cancer risk: effect modification by plasma antioxidants and the XRCC1 genotype. (PubMed id 16965236)1, 4 Goodman M....Mandel J.S. (Nutr Cancer 2006)
    459. Influence of polymorphism in DNA repair and defence genes on p53 mutations in bladder tumours. (PubMed id 16343742)1, 4 Ryk C....Hou S.M. (Cancer Lett. 2006)
    460. The association of XRCC1 haplotypes and chromosomal damage levels in peripheral blood lymphocyte among coke-oven workers. (PubMed id 15894689)1, 4 Leng S....Zheng Y. (amp 2005)
    461. Polymorphisms in DNA repair genes as risk factors for spina bifida and orofacial clefts. (PubMed id 15887293)1, 4 Olshan A.F....Finnell R.H. (Am. J. Med. Genet. A 2005)
    462. Influence of DNA repair gene polymorphisms on the yield of chromosomal aberrations. (PubMed id 15971256)1, 4 Kiuru A....Salomaa S. (Environ. Mol. Mutagen. 2005)
    463. DNA repair gene XRCC1 Arg399Gln polymorphism is associated with increased risk of uterine leiomyoma. (PubMed id 15760950)1, 4 Jeon Y.T....Lee H.P. (Hum. Reprod. 2005)
    464. DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients. (PubMed id 16369171)1, 4 Gal T.J....Schwartz S.M. (Laryngoscope 2005)
    465. Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma. (PubMed id 15878910)1, 4 Casson A.G....Guernsey D.L. (Carcinogenesis 2005)
    466. Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism. (PubMed id 15914210)1, 4 Festa F....Hemminki K. (Mutat. Res. 2005)
    467. DNA repair gene polymorphisms in relation to chromosome aberration frequencies in retired radiation workers. (PubMed id 15680411)1, 4 Wilding C.S....Tawn E.J. (Mutat. Res. 2005)
    468. Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer. (PubMed id 16425350)1, 4 Duarte M.C....Silva A.E. (World J. Gastroenterol. 2005)
    469. Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma. (PubMed id 16172101)1, 4 Chen C.C....Yu M.W. (Int J Epidemiol 2005)
    470. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    471. Selected DNA repair polymorphisms and gastric cancer in Poland. (PubMed id 15802298)1, 4 Huang W.Y....Hayes R.B. (Carcinogenesis 2005)
    472. Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity. (PubMed id 15734960)1, 4 Kirk G.D....Wild C.P. (amp 2005)
    473. TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. (PubMed id 15878096)1, 4 Andreassen C.N....Yarnold J. (Radiother Oncol 2005)
    474. Genetic variants of DNA repair genes and prostate cancer: a population-based study. (PubMed id 16030105)1, 4 Ritchey J.D....Hsing A.W. (amp 2005)
    475. The impact of genetic factors on the incidence of multiple primary tumors (MPT) of the head and neck. (PubMed id 15914277)1, 4 Rydzanicz M....Szyfter K. (Cancer Lett. 2005)
    476. Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. (PubMed id 15705867)1, 4 Zhang X....Lin D. (Cancer Res. 2005)
    477. Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis. (PubMed id 16030112)1, 4 Huang W.Y....Hayes R.B. (amp 2005)
    478. Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. (PubMed id 16221808)1, 4 Hung R.J....Boffetta P. (Am. J. Epidemiol. 2005)
    479. Genetic polymorphisms and the effect of cigarette smoking in the comet assay. (PubMed id 16037119)1, 4 Hoffmann H....Speit G. (Mutagenesis 2005)
    480. Association of XRCC1 Arg399Gln and OGG1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects. (PubMed id 15990162)1, 4 Niwa Y....Hamajima N. (Gynecol. Oncol. 2005)
    481. DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil. (PubMed id 16475125)1, 4 Dufloth R.M....Zeferino L.C. (Genet. Mol. Res. 2005)
    482. Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma. (PubMed id 15459223)1, 4 Berwick M....Vineis P. (J. Clin. Oncol. 2004)
    483. Lack of association between DNA base excision repair gene XRCC1 Gln399Arg polymorphism and risk of malignant lymphoma in Japan. (PubMed id 15104288)1, 4 Matsuo K....Tajima K. (Cancer Genet. Cytogenet. 2004)
    484. The protein kinase CK2 facilitates repair of chromosomal DNA single- strand breaks. (PubMed id 15066279)1, 2 Loizou J.I.... Caldecott K.W. (Cell 2004)
    485. Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PubMed id 15113441)1, 4 Sigurdson A.J....Struewing J.P. (BMC Cancer 2004)
    486. Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein. (PubMed id 14755728)1, 2 Sano Y....Tsuji S. (Ann. Neurol. 2004)
    487. [Genetic polymorphisms in X-ray repair cross-complementing gene 1 and susceptibility to papillary thyroid carcinoma]. (PubMed id 15555397)1, 4 Zhu Q.X....Wu Y. (Zhonghua Liu Xing Bing Xue Za Zhi 2004)
    488. Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA. (PubMed id 14729591)1, 4 Vodicka P....Hemminki K. (Carcinogenesis 2004)
    489. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    490. A population-based case-control study of the XRCC1 Arg399Gln polymorphism and susceptibility to bladder cancer. (PubMed id 15298955)1, 4 Kelsey K.T....Karagas M.R. (amp 2004)
    491. Aprataxin, a novel protein that protects against genotoxic stress. (PubMed id 15044383)1, 2 Gueven N.... Lavin M.F. (Hum. Mol. Genet. 2004)
    492. Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. (PubMed id 15205355)1, 4 Hao B....He F. (Cancer Res. 2004)
    493. Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations. (PubMed id 15450429)1, 4 Tuimala J....Norppa H. (Mutat. Res. 2004)
    494. Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk. (PubMed id 15044328)1, 4 Ito H....Tajima K. (Carcinogenesis 2004)
    495. Polymorphisms XRCC1-R399Q and XRCC3-T241M and the risk of breast cancer at the Ontario site of the Breast Cancer Family Registry. (PubMed id 15066923)1, 4 Figueiredo J.C....Ozcelik H. (amp 2004)
    496. High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia. (PubMed id 15159312)1, 4 Rollinson S....Morgan G.J. (amp 2004)
    497. Polymorphisms in DNA repair and metabolic genes in bladder cancer. (PubMed id 14688016)1, 4 Sanyal S.... Hemminki K. (Carcinogenesis 2004)
    498. The XRCC1 codon 399 Gln allele is associated with adenine to guanine p53 mutations in non-small cell lung cancer. (PubMed id 12873719)1, 4 Casse C....Ahrendt S.A. (Mutat. Res. 2003)
    499. Combination of DNA repair gene single nucleotide polymorphisms and increased levels of DNA adducts in a population-based study. (PubMed id 12869411)1, 4 Matullo G....Palli D. (amp 2003)
    500. Polymorphisms of the DNA repair genes XRCC1, XRCC3, XPD, interaction with environmental exposures, and bladder cancer risk in a case-control study in northern Italy. (PubMed id 14652287)1, 4 Shen M....Porru S. (amp 2003)
    501. Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. (PubMed id 14643949)1, 4 Andreassen C.N....Overgaard J. (Radiother Oncol 2003)
    502. Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma. (PubMed id 14519756)1, 4 Yu M.W....Chen C.J. (J. Natl. Cancer Inst. 2003)
    503. The XRCC1 399Gln polymorphism and the frequency of p53 mutations in Taiwanese oral squamous cell carcinomas. (PubMed id 12750239)1, 4 Hsieh L.L....Cheng A.J. (amp 2003)
    504. Allele Frequencies of 25 Polymorphisms Pertaining to Cancer Risk for Japanese, Koreans and Chinese. (PubMed id 12718576)1, 4 Hamajima N....Tajima K. (Asian Pac. J. Cancer Prev. 2002)
    505. XRCC1 genetic polymorphism and breast cancer risk. (PubMed id 12042672)1, 4 Kim S.U....Kang D. (Pharmacogenetics 2002)
    506. Effect of DNA repair gene polymorphisms on BPDE-DNA adducts in human lymphocytes. (PubMed id 12115580)1, 4 Pastorelli R....Airoldi L. (Int. J. Cancer 2002)
    507. Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians. (PubMed id 12175549)1, 4 Rossit A.R....Abdel-Rahman S.Z. (Cancer Lett. 2002)
    508. Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population. (PubMed id 12124811)1, 4 Xing D....Lin D. (Int. J. Cancer 2002)
    509. Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum. (PubMed id 11956078)1, 4 Gilliland F.D....Belinsky S.A. (Cancer Res. 2002)
    510. Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity. (PubMed id 12082022)1, 4 Tuimala J....Norppa H. (Carcinogenesis 2002)
    511. DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study. (PubMed id 11304692)1, 4 Matullo G....Vineis P. (Int. J. Cancer 2001)
    512. Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk. (PubMed id 11219768)1, 4 Ratnasinghe D....Taylor P.R. (amp 2001)
    513. Genetic polymorphisms in DNA repair genes and risk of lung cancer. (PubMed id 11285194)1, 4 Butkiewicz D....Harris C.C. (Carcinogenesis 2001)
    514. Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. (PubMed id 11058877)1, 4 Shen H....Wei Q. (Int. J. Cancer 2000)
    515. Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. (PubMed id 9485007)1, 2 Shen M.R.... Mohrenweiser H. (Cancer Res. 1998)
    516. PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro. (PubMed id 18678286)1, 9 Toulany M....Rodemann H.P. (DNA Repair (Amst.) 2008)
    517. XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair. (PubMed id 15927541)1, 9 Campalans A....Radicella J.P. (DNA Repair (Amst.) 2005)
    518. An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. (PubMed id 8264637)1, 9 Caldecott K.W....Thompson L.H. (Mol. Cell. Biol. 1994)
    519. XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case-control study. (PubMed id 20442803)1, 9 Zipprich J....Santella R.M. (J Carcinog 2010)
    520. XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells. (PubMed id 17603793)1, 9 Fan J....Wilson D.M. (Environ. Mol. Mutagen. 2007)
    521. Micronuclei in EM9 cells expressing polymorphic forms of human XRCC1. (PubMed id 15797631)1, 9 Qu T....Morimoto K. (Cancer Lett. 2005)
    522. XRCC1 co-localizes and physically interacts with PCNA. (PubMed id 15107487)1, 9 Fan J....Wilson D.M. (Nucleic Acids Res. 2004)
    523. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. (PubMed id 14500814)1, 9 El-Khamisy S.F....Caldecott K.W. (Nucleic Acids Res. 2003)
    524. Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1. (PubMed id 12933815)1, 9 Marsin S....Radicella J.P. (J. Biol. Chem. 2003)
    525. XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions. (PubMed id 11707423)1, 9 Vidal A.E....Radicella J.P. (EMBO J. 2001)
    526. XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions. (PubMed id 17880707)1, 9 Mortusewicz O. and Leonhardt H. (BMC Mol. Biol. 2007)
    527. XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates. (PubMed id 17650498)1, 9 Mani R.S....Weinfeld M. (J. Biol. Chem. 2007)
    528. XRCC1 is required for DNA single-strand break repair in human cells. (PubMed id 15867196)1, 9 Brem R. and Hall J. (Nucleic Acids Res. 2005)
    529. DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer. (PubMed id 14744728)4, 9 Rybicki B.A....Witte J.S. (amp 2004)
    530. X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance. (PubMed id 11809696)1, 9 Park S.Y....Cheng Y.C. (Cancer Res. 2002)
    531. Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1. (PubMed id 12198176)1, 9 Iftner T....Stubenrauch F. (EMBO J. 2002)
    532. Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1. (PubMed id 9705932)1, 9 Taylor R.M....Caldecott K.W. (Curr. Biol. 1998)
    533. XRCC1 protein interacts with one of two distinct forms of DNA ligase III. (PubMed id 9136882)1, 9 Nash R.A....Lindahl T. (Biochemistry 1997)
    534. Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. (PubMed id 8978692)1, 9 Kubota Y....Lindahl T. (EMBO J. 1996)
    535. A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment. (PubMed id 15367657)1, 9 Luo H....Qin J. (Mol. Cell. Biol. 2004)
    536. Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology. (PubMed id 19109787)1, 9 Jiang J....Wang W. (Methods Mol. Biol. 2009)
    537. [E2F1 upregulates endogenous XRCC1 expression]. (PubMed id 19031698)1, 9 Li J....Wu H. (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2008)
    538. Repair of radiation-induced heat-labile sites is independent of DNA-PKcs, XRCC1 and PARP. (PubMed id 18439038)1, 9 Karlsson K.H....StenerlAPw B. (Radiat. Res. 2008)
    539. XRCC1 polymorphism and lung cancer risk. (PubMed id 18999926)1, 9 Schneider J....Helmig S. (Expert Rev. Mol. Diagn. 2008)
    540. XRCC1 and XPD gene polymorphisms in a South Indian population. (PubMed id 17696747)1, 9 Vettriselvi V....Venkatachalam P. (Asian Pac. J. Cancer Prev. 2007)
    541. Reduced expression of human DNA repair genes in esophageal squamous-cell carcinoma in china. (PubMed id 17479411)1, 9 Liu R....Pu Y.P. (J. Toxicol. Environ. Health Part A 2007)
    542. XRCC1 Arg399Gln genetic polymorphism in a Turkish population. (PubMed id 16940014)1, 9 KocabaA9 N.A. and Karahalil B. (Int. J. Toxicol. 2006)
    543. The FHA domain of aprataxin interacts with the C-terminal region of XRCC1. (PubMed id 15555565)1, 9 Date H....Onodera O. (Biochem. Biophys. Res. Commun. 2004)
    544. Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling. (PubMed id 12643788)1, 9 Yacoub A....Hagan M.P. (Radiat. Res. 2003)
    545. DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. (PubMed id 12151350)1, 9 Chen S....Cho S.S. (Carcinogenesis 2002)
    546. Cloning and characterization of the promoter of baboon XRCC1, a gene involved in DNA strand-break repair. (PubMed id 9776979)1, 9 Zhou Z.Q. and Walter C.A. (Somat. Cell Mol. Genet. 1998)
    547. [Association between XRCC1 gene polymorphisms and DNA damage of workers exposed to formaldehyde]. (PubMed id 17290738)1, 9 Jiang S.F....Zheng Y.X. (Wei Sheng Yan Jiu 2006)
    548. XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair. (PubMed id 15838887)1, 9 Wong H.K. and Wilson D.M. (J. Cell. Biochem. 2005)
    549. Lack of influence of XRCC1 and XPD gene polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancers. (PubMed id 20104979)1, 9 Yao C.Y....Tang J.H. (Asian Pac. J. Cancer Prev. 2009)
    550. Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. (PubMed id 17953974)1, 9 Angelini S....Hrelia P. (Mutat. Res. 2008)
    551. Polymorphisms in the thymidylate synthase promoter and the DNA repair genes XRCC1 and XPD in a Brazilian population. (PubMed id 17111423)1, 9 Canalle R....Tone L.G. (Environ. Mol. Mutagen. 2006)
    552. Effects of low-dose gamma radiation on DNA damage, chromosomal aberration and expression of repair genes in human blood cells. (PubMed id 16872898)1, 9 Sudprasert W....Ruchirawat M. (Int J Hyg Environ Health 2006)
    553. Genetic polymorphisms of XRCC1, HOGG1 and MGMT and micronucleus occurrence in Chinese vinyl chloride-exposed workers. (PubMed id 20378691)1, 9 Wang Q....Xia Z.L. (Carcinogenesis 2010)
    554. Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution. (PubMed id 19800896)4, 9 Rubes J....Sram R.J. (Mutat. Res. 2010)
    555. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. (PubMed id 20227374)1, 9 Ogi T....Lehmann A.R. (Mol. Cell 2010)
    556. Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. (PubMed id 17507382)2, 9 Bekker-Jensen S.... Mailand N. (J. Biol. Chem. 2007)
    557. DNA repair pathway profiling and microsatellite instability in colorectal cancer. (PubMed id 16951227)1, 9 Yu J....McLeod H.L. (Clin. Cancer Res. 2006)
    558. Polymorphisms in glutathione S-transferases in French vinyl chloride workers. (PubMed id 16097394)1, 9 Li Y....Brandt-Rauf P.W. (Biomarkers 2005)
    559. Reduced DNA repair capacity in laryngeal cancer subjects. A comparison of phenotypic and genotypic results. (PubMed id 15608415)1, 9 Gajecka M....Szyfter K. (Adv. Otorhinolaryngol. 2005)
    560. XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. (PubMed id 15141024)1, 9 Dianova I.I....Dianov G.L. (Nucleic Acids Res. 2004)
    561. The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. (PubMed id 15380105)2, 9 Clements P.M....Caldecott K.W. (DNA Repair 2004)
    562. Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair. (PubMed id 12897160)1, 9 Leppard J.B....Tomkinson A.E. (Mol. Cell. Biol. 2003)
    563. Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair. (PubMed id 11909950)1, 9 Taylor R.M....Caldecott K.W. (Mol. Cell. Biol. 2002)
    564. Expression profiling of cancer-related genes in human keratinocytes following non-lethal ultraviolet B irradiation. (PubMed id 11532376)1, 9 Murakami T....Nakagawa H. (J. Dermatol. Sci. 2001)
    565. BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III. (PubMed id 11352725)1, 9 Dulic A....Barnes D.E. (Biochemistry 2001)
    566. Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR. (PubMed id 7585546)1, 9 Wei Q....Ali-Osman F. (Cancer Res. 1995)
    567. Genetic polymorphisms in XRCC1 gene and susceptibility to glioma in Chinese Han population. (PubMed id 23918303)1 Jin Z....Zhao G. (Tumour Biol. 2014)
    568. X-ray repair cross-complementing group 1 codon 399 polymorphism and lung cancer risk: an updated meta-analysis. (PubMed id 23943371)1 Wang J.Y. and Cai Y. (Tumour Biol. 2014)
    569. Association of genetic variants in CDK6 and XRCC1 with the risk of dysplastic nevi in melanoma-prone families. (PubMed id 23892592)1 Liang X....Yang X.R. (J. Invest. Dermatol. 2014)
    570. XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients. (PubMed id 24292986)1 Zhou Y....Liu H. (Tumour Biol. 2014)
    571. Association of XRCC1 gene single nucleotide polymorphisms and susceptibility to pancreatic cancer in Chinese. (PubMed id 23893380)1 Chen H....Chen P. (Tumour Biol. 2014)
    572. Association of XRCC1 Arg399Gln polymorphism with bladder cancer susceptibility: a meta-analysis. (PubMed id 24176953)1 Yang D....Wang Y. (Gene 2014)
    573. Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair. (PubMed id 23355608)1 Campalans A....Radicella J.P. (Nucleic Acids Res. 2013)
    574. Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer? (PubMed id 22894650)1 Abdel-Fatah T....Madhusudan S. (amp 2013)
    575. XRCC1 Arg399Gln and Arg194Trp polymorphisms in childhood acute lymphoblastic leukemia risk: a meta-analysis. (PubMed id 22712837)1 Wang R....Wei B. (amp 2013)
    576. Association of XRCC1 gene polymorphisms with breast cancer susceptibility in Saudi patients. (PubMed id 23886187)1 Al Mutairi F.M....Parine N.R. (Asian Pac. J. Cancer Prev. 2013)
    577. Meta-analysis demonstrates association of XRCC1 genetic polymorphism Arg399Gln with esophageal cancer risk in the Chinese population. (PubMed id 23359058)1 Zhang Z.Y....Wu R. (Genet. Mol. Res. 2013)
    578. XRCC1 gene polymorphisms and the risk of differentiated thyroid carcinoma (DTC): a meta-analysis of case-control studies. (PubMed id 23717668)1 Bao Y....Shi Y.Q. (PLoS ONE 2013)
    579. Association of XRCC1 gene polymorphisms with the survival and clinicopathological characteristics of gastric cancer. (PubMed id 23425027)1 Zhang Y....Chen J. (DNA Cell Biol. 2013)
    580. The genotype distribution of the XRCC1, XRCC3, and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia. (PubMed id 23397959)1 Sorour A....Kassem H. (Genet Test Mol Biomarkers 2013)
    581. XRCC1 Arg399Gln polymorphism is not associated with oral cancer risk: evidence from a meta-analysis. (PubMed id 24052436)1 Liu B. and Shen T. (Tumour Biol. 2013)
    582. X-ray repair cross-complementing group 1 Arg399Gln gene polymorphism and susceptibility to colorectal cancer:a meta-analysis. (PubMed id 23188703)1 Zeng F.R....Luo R.C. (Tumour Biol. 2013)
    583. Association between X-ray repair cross-complementing group 1 Arg194Trp polymorphism and colorectal cancer risk. (PubMed id 23857281)1 Mao D....Fu X. (Tumour Biol. 2013)
    584. XRCC1 Arg194Trp and Arg280His polymorphisms increase bladder cancer risk in Asian population: evidence from a meta-analysis. (PubMed id 23704969)1 Fang Z....Ye G. (PLoS ONE 2013)
    585. Lys751Gln XPD and Arg399Gln XRCC1 in Romanians. Association with sporadic colorectal cancer risk and different stages of carcinomas. (PubMed id 24157118)1 Procopciuc L.M. and Osian G. (Chirurgia (Bucur) 2013)
    586. XRCC1 Arg399Gln polymorphism and bladder cancer risk: updated meta-analyses based on 5767 cases and 6919 controls. (PubMed id 23479765)1 Zhuo W....Chen Z. (Exp. Biol. Med. (Maywood) 2013)
    587. Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes. (PubMed id 24053728)1 da Silva A.L....Henriques J.A. (BMC Med. Genet. 2013)
    588. XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms in esophageal cancer risk: a meta-analysis. (PubMed id 23543084)1 Li S....Qin X. (Dig. Dis. Sci. 2013)
    589. Polymorphisms of DNA repair genes XPD, XRCC1, and OGG1, and lung adenocarcinoma susceptibility in Chinese population. (PubMed id 23700156)1 Ouyang F.D....Zhang D.Z. (Tumour Biol. 2013)
    590. Association between the XRCC1 polymorphisms and glioma risk: a meta-analysis of case-control studies. (PubMed id 23383237)1 Jiang L....Lu Y.C. (PLoS ONE 2013)
    591. Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults. (PubMed id 22427030)1 Kostrzewska-Poczekaj M....Szyfter K. (Eur Arch Otorhinolaryngol 2013)
    592. Association between the C.1161G&gt;A and C.1779C&gt;G genetic variants of XRCC1 gene and hepatocellular carcinoma risk in Chinese population. (PubMed id 23493666)1 Deng X....Liu H. (Int. J. Biol. Sci. 2013)
    593. Arg399Gln polymorphism of X-ray repair cross-complementing group 1 gene is associated with angiographically documented coronary artery disease in South Indian type 2 diabetic patients. (PubMed id 23360319)1 Narne P....Ishaq M. (Genet Test Mol Biomarkers 2013)
    594. X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population. (PubMed id 23653378)1 Wu T....Ye X.L. (Tumour Biol. 2013)
    595. Clinicopathological and functional significance of XRCC1 expression in ovarian cancer. (PubMed id 23225521)1 Abdel-Fatah T....Madhusudan S. (Int. J. Cancer 2013)
    596. Associations between three XRCC1 polymorphisms and glioma risk: a meta-analysis. (PubMed id 23712607)1 Zhang H....Knauss J.L. (Tumour Biol. 2013)
    597. A meta-analysis of an association between the XRCC1 polymorphisms and gliomas risk. (PubMed id 23238971)1 Li M....Jiang Y. (J. Neurooncol. 2013)
    598. Association of XRCC1 gene polymorphisms with chronic myeloid leukemia in the population of Andhra Pradesh, India. (PubMed id 23320983)1 Annamaneni S....Battini M.R. (Hematology 2013)
    599. Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells. (PubMed id 23451157)1 Sultana R....Madhusudan S. (PLoS ONE 2013)
    600. Association of the Arg194Trp and the Arg399Gln polymorphisms of the XRCC1 gene with risk occurrence and the response to adjuvant therapy among Polish women with breast cancer. (PubMed id 23103366)1 Przybylowska-Sygut K....Majsterek I. (Clin. Breast Cancer 2013)
    601. Decreased expression of DNA repair genes (XRCC1, ERCC1, ERCC2, and ERCC4) in squamous intraepithelial lesion and invasive squamous cell carcinoma of the cervix. (PubMed id 23435956)1 Bajpai D....Singh N. (Mol. Cell. Biochem. 2013)
    602. Relationship between glutathione S-transferase P1 (GSTP1), X-ray repair cross complementing group 1 (XRCC1) and 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene polymorphisms and response to chemotherapy in advanced gastric cancer. (PubMed id 23774147)1 Ji M....Wu C.P. (Onkologie 2013)
    603. Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy. (PubMed id 23553206)1 Sacerdote C....Matullo G. (Int. J. Cancer 2013)
    604. DNA repair genes polymorphism and lung cancer risk with the emphasis to sex differences. (PubMed id 23673479)1 Letkova L....Halasova E. (Mol. Biol. Rep. 2013)
    605. Polymorphisms in DNA repair genes and risk of glioma and meningioma. (PubMed id 23534771)1 Luo K.Q....Peng J.C. (Asian Pac. J. Cancer Prev. 2013)
    606. Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis. (PubMed id 23055199)1 Li J....Zhang S. (Tumour Biol. 2013)
    607. Quantitative assessment of the associations between XRCC1 polymorphisms and bladder cancer risk. (PubMed id 23496911)1 Mao Y....Xie L. (World J Surg Oncol 2013)
    608. Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: association with hepatitis B related advanced liver disease and cancer. (PubMed id 23454624)1 Bose S....Sarin S.K. (Gene 2013)
    609. Genetic variations in XRCC1 gene in sporadic head and neck cancer (HNC) patients. (PubMed id 23055018)1 Mahjabeen I....Kayani M.A. (Pathol. Oncol. Res. 2013)
    610. Association between XRCC1 Arg399Gln polymorphism and hepatitis virus-related hepatocellular carcinoma risk in Asian population. (PubMed id 23780894)1 Wu D....Li Z. (Tumour Biol. 2013)
    611. Epidemiological, clinical, and molecular study of a cohort of Italian Parkinson disease patients: association with glutathione-S-transferase and DNA repair gene polymorphisms. (PubMed id 23552977)1 Cornetta T....Cozzi R. (Cell. Mol. Neurobiol. 2013)
    612. Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case-control studies. (PubMed id 23271134)1 Liu L....Fan Z. (Mol. Biol. Rep. 2013)
    613. Polymorphisms in the base excision repair pathway modulate prognosis of platinum-based chemotherapy in advanced non-small cell lung cancer. (PubMed id 23479135)1 Zhao W....Yin Y. (Cancer Chemother. Pharmacol. 2013)
    614. Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients. (PubMed id 22775506)1 Dos Reis M.B....de Syllos CA^lus I.M. (amp 2013)
    615. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. (PubMed id 23409158)1 Guo S....Niu W. (PLoS ONE 2013)
    616. Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population. (PubMed id 23430444)1 Li Y....Zhao Y. (Med. Oncol. 2013)
    617. XRCC1 gene polymorphisms and risk of ameloblastoma. (PubMed id 23177933)1 Yanatatsaneejit P....Kitkumthorn N. (Arch. Oral Biol. 2013)
    618. Association between polymorphisms of XRCC1 and ADPRT genes and ovarian cancer survival with platinum-based chemotherapy in Chinese population. (PubMed id 22983827)1 Li K. and Li W. (Mol. Cell. Biochem. 2013)
    619. Association of the 399Arg/Gln XRCC1, the 194 Arg/Trp XRCC1, the 326Ser/Cys OGG1, and the 324Gln/His MUTYH gene polymorphisms with clinical parameters and the risk for development of primary open-angle glaucoma. (PubMed id 23499241)1 Szaflik J.P....Majsterek I. (Mutat. Res. 2013)
    620. XRCC1 polymorphisms and differentiated thyroid carcinoma risk: a meta-analysis. (PubMed id 23872202)1 Hu Z....Wei B. (Gene 2013)
    621. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    622. Association of the CYP1A1*2A, GSTT1 null, GSTM1 null, mEPHX*3, and XRCC1-399 genetic polymorphisms with ulcerative colitis. (PubMed id 22664944)1 Buyukgoze O....Sen A. (Int J Colorectal Dis 2013)
    623. Association between X-ray repair cross-complementation group 1 rs25487 polymorphism and pancreatic cancer risk. (PubMed id 23807675)1 Jiang H....Jin J. (Tumour Biol. 2013)
    624. Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus. (PubMed id 23044807)1 Gulnaz A....Ali M. (amp 2013)
    625. The influence of XPD, APE1, XRCC1, and NBS1 polymorphic variants on DNA repair in cells exposed to X-rays. (PubMed id 23669291)1 Gdowicz-Klosok A....Rzeszowska-Wolny J. (Mutat. Res. 2013)
    626. Assessment of the association between XRCC1 Arg399Gln polymorphism and lung cancer in Chinese. (PubMed id 23884604)1 Li Y....Zhuo A.S. (Tumour Biol. 2013)
    627. Meta-analysis demonstrates lack of a relationship between XRCC1-399 gene polymorphisms and susceptibility to hepatocellular carcinoma. (PubMed id 23546985)1 Zeng X.Y....Qiu X.Q. (Genet. Mol. Res. 2013)
    628. Gene polymorphism of XRCC1 Arg399Gln and cervical carcinoma susceptibility in Asians: a meta-analysis based on 1,759 cases and 2,497 controls. (PubMed id 23534722)1 Liu Y.T....Wu X.M. (Asian Pac. J. Cancer Prev. 2013)
    629. Association study of single nucleotide polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in Chinese Han population. (PubMed id 23984316)1 Bi J....Wang B. (Biomed Res Int 2013)
    630. Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy. (PubMed id 23996617)1 Huang M.Y....Wang J.Y. (J Surg Oncol 2013)
    631. XRCC1 deficiency increased the DNA damage induced by I^-ray in HepG2 cell: Involvement of DSB repair and cell cycle arrest. (PubMed id 23708312)1 Niu Y....Zhang R. (Environ. Toxicol. Pharmacol. 2013)
    632. XRCC1 codon 399Gln polymorphism is associated with radiotherapy-induced acute dermatitis and mucositis in nasopharyngeal carcinoma patients. (PubMed id 23375119)1 Li H....Chen Z. (Radiat Oncol 2013)
    633. An association selected polymorphisms of XRCC1, OGG1 and MUTYH gene and the level of efficiency oxidative DNA damage repair with a risk of colorectal cancer. (PubMed id 23618615)1 Przybylowska K....Majsterek I. (Mutat. Res. 2013)
    634. Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. (PubMed id 22821704)1 Liu L....Miao X. (Mol. Carcinog. 2013)
    635. XRCC1 polymorphisms increase bladder cancer risk in Asians: a meta-analysis. (PubMed id 23636799)1 Zhang F....Liu H.T. (Tumour Biol. 2013)
    636. XRCC1 codon 280 polymorphism and susceptibility to lung cancer: a meta-analysis of the literatures. (PubMed id 23733202)1 Guo Q.X....Wang C.Y. (Tumour Biol. 2013)
    637. XRCC1 Arg194Trp polymorphism is associated with oral cancer risk: evidence from a meta-analysis. (PubMed id 23681796)1 Zhang Y....Li L.J. (Tumour Biol. 2013)
    638. XRCC1 and GSTP1 polymorphisms and prognosis of oxaliplatin-based chemotherapy in colorectal cancer: a meta-analysis. (PubMed id 23299794)1 Ye F....Yang X. (Cancer Chemother. Pharmacol. 2013)
    639. Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin. (PubMed id 23313170)1 Kelsey C.R....Marks L.B. (Clin Lung Cancer 2013)
    640. Association study of single nucleotide polymorphisms in XRCC1 gene with the risk of gastric cancer in Chinese population. (PubMed id 23983608)1 Qiao W....Sun H. (Int. J. Biol. Sci. 2013)
    641. The XRCC1 Arg280His gene polymorphism and hepatocellular carcinoma risk: a meta-analysis. (PubMed id 23679314)1 Li L.P....Song S.S. (Asian Pac. J. Cancer Prev. 2013)
    642. A functional polymorphism in XRCC1 is associated with glioma risk: evidence from a meta-analysis. (PubMed id 23096083)1 Wei X....Lv T. (Mol. Biol. Rep. 2013)
    643. XRCC1 Arg399Gln polymorphism contributes to increased risk of colorectal cancer in Chinese population. (PubMed id 23712778)1 Tian Z....Liu J.G. (Mol. Biol. Rep. 2013)
    644. Genetic polymorphism of XRCC1 Arg399Gln is associated with survival in non-small-cell lung cancer patients treated with gemcitabine/platinum. (PubMed id 22551904)1 Liao W.Y....Yu C.J. (J Thorac Oncol 2012)
    645. Impact of DNA repair genes polymorphism (XPD and XRCC1) on the risk of breast cancer in Egyptian female patients. (PubMed id 21643959)1 Hussien Y.M....Elsawy W.H. (Mol. Biol. Rep. 2012)
    646. XRCC1 Arg399Gln gene polymorphism and the risk of systemic lupus erythematosus in the Polish population. (PubMed id 21682595)1 WarchoA8 T....JagodziA8ski P.P. (DNA Cell Biol. 2012)
    647. Association between XRCC1 gene polymorphisms and risk of glioma development: a meta-analysis. (PubMed id 23167420)1 Sun J.Y....Mei X.L. (Asian Pac. J. Cancer Prev. 2012)
    648. Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India. (PubMed id 22081374)1 Kumar A....Khandelwal S. (Tumour Biol. 2012)
    649. Association of XPD and XRCC1 genetic polymorphisms with hepatocellular carcinoma risk. (PubMed id 23167354)1 Guo L.Y....Wang Y.L. (Asian Pac. J. Cancer Prev. 2012)
    650. Genetic polymorphism of XRCC1 correlated with response to oxaliplatin-based chemotherapy in advanced colorectal cancer. (PubMed id 22549274)1 Lv H....Liang J. (Pathol. Oncol. Res. 2012)
    651. Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: possible implications on survival. (PubMed id 22659345)1 Jung S.W....Chung Y.H. (J. Hepatol. 2012)
    652. Genetic polymorphisms in DNA repair genes OGG1, APE1, XRCC1, and XPD and the risk of age-related cataract. (PubMed id 22306120)1 Zhang Y....Liu P. (Ophthalmology 2012)
    653. Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair. (PubMed id 22266871)1 Kudo K....Reed E. (Oncogene 2012)
    654. Prediction value of XRCC 1 gene polymorphism on the survival of ovarian cancer treated by adjuvant chemotherapy. (PubMed id 23244100)1 Miao J....Kai L. (Asian Pac. J. Cancer Prev. 2012)
    655. Association between XRCC1 single-nucleotide polymorphisms and infertility with idiopathic azoospermia in northern Chinese Han males. (PubMed id 22868082)1 Zheng L.R....Tian H. (Reprod. Biomed. Online 2012)
    656. X-ray cross-complementing group 1 and thymidylate synthase polymorphisms might predict response to chemoradiotherapy in rectal cancer patients. (PubMed id 21167658)1 Lamas M.J....Barros F. (Int. J. Radiat. Oncol. Biol. Phys. 2012)
    657. Prediction of genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 in the survival of colorectal cancer receiving chemotherapy in the Chinese population. (PubMed id 22580644)1 Liu Y....Hu C. (Hepatogastroenterology 2012)
    658. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    659. Functional polymorphisms in XRCC-1 and APE-1 contribute to increased apoptosis and risk of ulcerative colitis. (PubMed id 22193858)1 Bardia A....Khan A.A. (Inflamm. Res. 2012)
    660. DNA repair genes in Parkinson's disease. (PubMed id 22224629)1 Gencer M....Aydin M. (Genet Test Mol Biomarkers 2012)
    661. The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. (PubMed id 22992732)1 Della-Maria J....Tomkinson A.E. (J. Biol. Chem. 2012)
    662. Rheumatoid arthritis risk associates with DNA repair gene XRCC1 Arg399Gln polymorphism in Turkish patients. (PubMed id 21267572)1 Yosunkaya E....Sultuybek G.K. (Rheumatol. Int. 2012)
    663. Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. (PubMed id 22850545)1 Nakao M....Matsuo K. (J Epidemiol 2012)
    664. XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population: a meta-analysis. (PubMed id 23098440)1 Duan W.H....Zhou N.X. (Asian Pac. J. Cancer Prev. 2012)
    665. Investigation of Arg399Gln and Arg194Trp polymorphisms of the XRCC1 (x-ray cross-complementing group 1) gene and its correlation to sister chromatid exchange frequency in patients with chronic lymphocytic leukemia. (PubMed id 22106831)1 Duman N....Cefle K. (Genet Test Mol Biomarkers 2012)
    666. No association between DNA repair gene XRCC1 and amyotrophic lateral sclerosis. (PubMed id 20719408)1 Fang F....Kamel F. (Neurobiol. Aging 2012)
    667. [The polymorphism of DNA repair genes XRCC1, XRCC3 and the level of chromosomal aberrations in the Uranium workers]. (PubMed id 22568010)1 Vasil'eva Z.Z.h....Vorobtsova I.E. (Radiats Biol Radioecol 2012)
    668. DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome. (PubMed id 21974800)1 Reeves S.G....Scott R.J. (Cancer Epidemiol 2012)
    669. Evaluation of DNA repair gene XRCC1 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. (PubMed id 22502666)1 Li Q.W....Liang J. (Asian Pac. J. Cancer Prev. 2012)
    670. X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis. (PubMed id 22984511)1 Li Y....Li S.W. (PLoS ONE 2012)
    671. XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case-control studies. (PubMed id 22729882)1 Dai L....Zhang J. (Mol. Biol. Rep. 2012)
    672. Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. (PubMed id 22524842)1 Zhao Y....Liu Y. (Asian Pac. J. Cancer Prev. 2012)
    673. Associated risk of XRCC1 and XPD cross talk and life style factors in progression of head and neck cancer in north Indian population. (PubMed id 21945240)1 Kumar A....Khandelwal S. (Mutat. Res. 2012)
    674. Association between single nucleotide polymorphisms in the XRCC1 gene and susceptibility to prostate cancer in Chinese men. (PubMed id 23244143)1 Zhou Y.F....Hou J.Q. (Asian Pac. J. Cancer Prev. 2012)
    675. Predictive value of XRCC1 gene polymorphisms on platinum-based chemotherapy in advanced non-small cell lung cancer patients: a systematic review and meta-analysis. (PubMed id 22705987)1 Wu J....Wang J.C. (Clin. Cancer Res. 2012)
    676. DNA repair polymorphisms and treatment outcomes of patients with malignant mesothelioma treated with gemcitabine-platinum combination chemotherapy. (PubMed id 22982660)1 ErA8ulj N....DolA3an V. (J Thorac Oncol 2012)
    677. Prognostic significance of GSTP1, XRCC1 and XRCC3 polymorphisms in non-small cell lung cancer patients. (PubMed id 23167352)1 Ke H.G....Shen Z.Y. (Asian Pac. J. Cancer Prev. 2012)
    678. Study on the DNA repair gene XRCC1 and XRCC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. (PubMed id 22456434)1 Han X....Jun L. (Hepatogastroenterology 2012)
    679. Association between XRCC1 polymorphism 399 G-&gt;A and glioma among Caucasians: a systematic review and meta-analysis. (PubMed id 23101479)1 Jacobs D.I. and Bracken M.B. (BMC Med. Genet. 2012)
    680. MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer. (PubMed id 22843073)1 MuA+iz-Mendoza R....GutiAcrrez-Angulo M. (Genet. Mol. Res. 2012)
    681. DNA repair gene polymorphisms at XRCC1 (Arg194Trp, Arg280His, and Arg399Gln) in a healthy Tunisian population: interethnic variation and functional prediction. (PubMed id 23057594)1 Salah G.B....Kamoun H. (Genet Test Mol Biomarkers 2012)
    682. [Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population]. (PubMed id 22611936)1 Wang N....Wu Y. (Wei Sheng Yan Jiu 2012)
    683. Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: a case-control study. (PubMed id 22951806)1 Wang D....Liu A. (Gene 2012)
    684. The XRCC1 Arg280His polymorphism contributes to cancer susceptibility: an update by meta-analysis of 53 individual studies. (PubMed id 22975644)1 Zhang K....Zhang L. (Gene 2012)
    685. Association of genetic variations in X-ray repair cross-complementing group 1 and Tourette syndrome. (PubMed id 23001975)1 Lin W.Y....Tsai F.J. (J. Clin. Lab. Anal. 2012)
    686. Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis. (PubMed id 21604176)1 Chen B....Wu X.T. (Mol. Biol. Rep. 2012)
    687. Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population. (PubMed id 22687647)1 Santonocito C....Capoluongo E. ( international journal of clinical chemistry 2012)
    688. XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies. (PubMed id 23125080)1 Chen J....Wang L.R. (J Zhejiang Univ Sci B 2012)
    689. Polymorphisms of base-excision repair genes hOGG1 326cys and XRCC1 280His increase hepatocellular carcinoma risk. (PubMed id 22565339)1 Yuan T....Chen P. (Dig. Dis. Sci. 2012)
    690. Predictive value of excision repair cross-complementing rodent repair deficiency complementation group 1 and ovarian cancer risk. (PubMed id 22901125)1 He S.Y....Shen H.W. (Asian Pac. J. Cancer Prev. 2012)
    691. XRCC1 Arg194Trp polymorphism, risk of nonmelanoma skin cancer and extramammary Paget's disease in a Japanese population. (PubMed id 22639094)1 Chiyomaru K....Nishigori C. (Arch. Dermatol. Res. 2012)
    692. Genetic polymorphisms (at codons 194 and 399) in the DNA repair gene XRCC1 and susceptibility to bipolar disorder. (PubMed id 22374554)1 Saadat M....Saadat I. (Psychiatry Res 2012)
    693. Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study. (PubMed id 23317230)1 Pan X.F....Yang C.X. (Asian Pac. J. Cancer Prev. 2012)
    694. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    695. Decreased mRNA expression levels of base excision repair (BER) pathway genes is associated with enhanced Ki-67 expression in HNSCC. (PubMed id 22798271)1 Mahjabeen I....Kayani M.A. (Med. Oncol. 2012)
    696. Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican Americans. (PubMed id 22135187)1 Zhang L....Khudyakov Y. (Hepatology 2012)
    697. No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese. (PubMed id 22579466)1 Yin J....Sun X. (Gene 2012)
    698. Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis. (PubMed id 22339849)1 Cui Z....Zhou B. (BMC Cancer 2012)
    699. X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and risk of childhood acute lymphoblastic leukemia: a meta-analysis. (PubMed id 22529951)1 Wang L....Zhao D. (PLoS ONE 2012)
    700. DNA repair genes polymorphism (XPG and XRCC1) and association of prostate cancer in a north Indian population. (PubMed id 21670956)1 Berhane N....Mahdi S.A. (Mol. Biol. Rep. 2012)
    701. [Polymorphism of XRCC1 and chromosome damage in workers occupationally exposed to benzene]. (PubMed id 22931768)1 Zhang J....Xia Z.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2012)
    702. The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1. (PubMed id 22281126)1 Hanssen-Bauer A....Otterlei M. (DNA Repair (Amst.) 2012)
    703. Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis. (PubMed id 23212324)1 Liu B.M....He Y.C. (Genet. Mol. Res. 2012)
    704. [Explore the genotype characteristics of DNA repair enzyme XRCC1 and XPD in the lens epithelium associated with free radical level in the age-related cataract patients]. (PubMed id 22932335)1 Wang X....Zhang M.C. (Zhonghua Yan Ke Za Zhi 2012)
    705. Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia. (PubMed id 21983886)1 Tumer T.B....ArinAs E. (Arch. Toxicol. 2012)
    706. Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer. (PubMed id 22452940)1 Wang S....Zhou J. (Clin. Cancer Res. 2012)
    707. XPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear. (PubMed id 23161045)1 Yilmaz E....Yesilada E. (Eur Rev Med Pharmacol Sci 2012)
    708. Human CCAAT/enhancer-binding protein I^ interacts with chromatin remodeling complexes of the imitation switch subfamily. (PubMed id 22242598)1 Steinberg X.P....GutiAcrrez J.L. (Biochemistry 2012)
    709. DNA repair XRCC1 Arg399Gln polymorphism is associated with the risk of development of end-stage renal disease. (PubMed id 22302399)1 Trabulus S....Guven M. (Mol. Biol. Rep. 2012)
    710. XRCC1-77T&gt;C polymorphism and cancer risk: a meta- analysis. (PubMed id 22502651)1 Wang Y.G. and Zheng T.Y. (Asian Pac. J. Cancer Prev. 2012)
    711. DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma. (PubMed id 22047709)1 Ozdemir N....GA1ven M. (Leuk. Res. 2012)
    712. Association between polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln genes and prognosis of colorectal cancer in a Chinese population. (PubMed id 23317245)1 Gan Y....Wu J.H. (Asian Pac. J. Cancer Prev. 2012)
    713. Polymorphisms in human DNA repair genes and head and neck squamous cell carcinoma. (PubMed id 23271025)1 Khlifi R....Hamza-Chaffai A. (J. Genet. 2012)
    714. [The polymorphisms of XRCC1 gene and susceptibility to pulmonary cancer]. (PubMed id 22730687)1 Wang N....Wu Y.M. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2012)
    715. Association between polymorphisms in DNA repair genes (XRCC1 and XRCC7) and risk of preeclampsia. (PubMed id 22825692)1 Saadat I....Saadat M. (Arch. Gynecol. Obstet. 2012)
    716. XRCC1 and ADPRT polymorphisms associated with survival in breast cancer cases treated with chemotherapy. (PubMed id 23244082)1 Ye S....Wang S.M. (Asian Pac. J. Cancer Prev. 2012)
    717. The cAMP signaling system inhibits the repair of I^-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells. (PubMed id 22575451)1 Cho E.A. and Juhnn Y.S. (Biochem. Biophys. Res. Commun. 2012)
    718. Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan. (PubMed id 22186158)1 Yin G....Terasaka R. (J Epidemiol 2012)
    719. Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy. (PubMed id 22537351)1 Raabe A....Dikomey E. (Radiat Oncol 2012)
    720. X-ray repair cross-complementing group 1 polymorphisms and hepatocellular carcinoma: a meta-analysis. (PubMed id 22919255)1 Xie T....Liu H. (World J. Gastroenterol. 2012)
    721. [Interaction between polymorphisms in NQO1(C609T) and XRCC1(G28152A) and their correlation with smoking on gastric cancer]. (PubMed id 21518531)1 Chen D.J....Ye D.Q. (Zhonghua Liu Xing Bing Xue Za Zhi 2011)
    722. Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia. (PubMed id 21463130)1 Canalle R....Tone L.G. (amp 2011)
    723. Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population. (PubMed id 21722819)1 Li Z....Wang D. (Arch. Med. Res. 2011)
    724. Polymorphisms in DNA repair gene XRCC1 and skin cancer risk: a meta-analysis. (PubMed id 22110224)1 Zhang H....Dudek A.Z. (Anticancer Res. 2011)
    725. XRCC1 and XPD DNA repair gene polymorphisms: a potential risk factor for glaucoma in the Pakistani population. (PubMed id 21617750)1 Yousaf S....Qamar R. (Mol. Vis. 2011)
    726. Polymorphisms of DNA repair gene XRCC1 and risk of glioma: a case-control study in Southern China. (PubMed id 22320953)1 Zhou L.Q....Kong W.L. (Asian Pac. J. Cancer Prev. 2011)
    727. Polymorphism in the DNA repair enzyme XRCC1: utility of current database and implications for human health risk assessment. (PubMed id 21352951)1 Ginsberg G....Sonawane B. (Mutat. Res. 2011)
    728. [Polymorphisms of DNA repair genes ERCC2 and XRCC1 in populations of Russia]. (PubMed id 22332413)1 Khrunin A.V....Limborskaia S.A. (Genetika 2011)
    729. Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. (PubMed id 22009704)1 Zhou F....Liang J. (Swiss Med Wkly 2011)
    730. Assessment of XPD Lys751Gln and XRCC1 T-77C polymorphisms in advanced non-small-cell lung cancer patients treated with platinum-based chemotherapy. (PubMed id 21129812)1 Liu L....Lin D. (Lung Cancer 2011)
    731. XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women. (PubMed id 21797115)1 Barbisan G....Golijow C.D. (Eur. J. Gynaecol. Oncol. 2011)
    732. Lack of any relationship between chemotherapy toxicity in non-small cell lung cancer cases and polymorphisms in XRCC1 codon 399 or XPD codon 751. (PubMed id 21627375)1 Li Y....Xu L. (Asian Pac. J. Cancer Prev. 2011)
    733. Polymorphism of DNA repair gene XRCC1 and hepatocellular carcinoma risk in Chinese population. (PubMed id 22393969)1 Pan H.Z....Wang Q. (Asian Pac. J. Cancer Prev. 2011)
    734. Interaction between XRCC1 polymorphisms and intake of long-term stored rice in the risk of esophageal squamous cell carcinoma: a case-control study. (PubMed id 21784313)1 Yu H....Xu B. (Biomed. Environ. Sci. 2011)
    735. Association between Arg399Gln polymorphism of X-ray repair cross-complementing 1 (XRCC1) gene and sporadic endometrial cancer in the Polish population. (PubMed id 22053659)1 Samulak D....Sporny S. (Eur. J. Gynaecol. Oncol. 2011)
    736. Single nucleotide polymorphism in DNA base excision repair genes XRCC1 and hOGG1 and the risk of endometrial carcinoma in the Polish population. (PubMed id 21866464)1 Romanowicz-Makowska H....SzyA8A8o K. (Pol J Pathol 2011)
    737. Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer. (PubMed id 21704413)1 Pratesi N....Orlando C. (Radiother Oncol 2011)
    738. Serum testosterone in females exposed to natural sour gas with respect to polymorphisms of XRCC1, GSTM1, and GSTT1. (PubMed id 20300859)1 Saadat M. and Saadat I. (Mol. Biol. Rep. 2011)
    739. Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran. (PubMed id 21987112)1 Fard-Esfahani P....Majdi M. (Iran. Biomed. J. 2011)
    740. [The peculiarities of polymorphism of XPD and XRCC1 repair genes in cells of Down and Ehlers-Danlo syndrome patients characterized by increased radiosensitivity]. (PubMed id 21950097)1 Shagirova Z.h.M....Zasukhina G.D. (Radiats Biol Radioecol 2011)
    741. Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group. (PubMed id 21586140)1 Yoon H.H....Gibson M.K. (BMC Cancer 2011)
    742. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. (PubMed id 20863780)1 Yuan T....Xia J. (Cancer Epidemiol 2011)
    743. Association between single nucleotide polymorphisms in the gene for XRCC1 and radiation-induced late toxicity in prostate cancer patients. (PubMed id 21345510)1 Langsenlehner T....Langsenlehner U. (Radiother Oncol 2011)
    744. DNA repair gene polymorphism is associated with the genetic basis of atherosclerotic coronary artery disease. (PubMed id 20093049)1 Bazo A.P....Salvadori D.M. (Cardiovasc. Pathol. 2011)
    745. The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese Mainland population: a meta-analysis. (PubMed id 21499756)1 Huang J....Wang L. (Mol. Biol. Rep. 2011)
    746. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    747. Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting. (PubMed id 21909257)1 Chase G.P....Schwemmle M. (PLoS Pathog. 2011)
    748. XRCC1 Arg399Gln gene polymorphism and breast cancer risk: a meta-analysis based on case-control studies. (PubMed id 22296363)1 Wu K....Au W.W. (Asian Pac. J. Cancer Prev. 2011)
    749. XRCC1 and hOGG1 genes and risk of nasopharyngeal carcinoma in North African countries. (PubMed id 21520294)1 Laantri N....Corbex M. (Mol. Carcinog. 2011)
    750. XRCC1 and ERCC1 variants modify malignant mesothelioma risk: a case-control study. (PubMed id 21277872)1 Betti M....Dianzani I. (Mutat. Res. 2011)
    751. Genetic risk of DNA repair gene polymorphisms (XRCC1 and XRCC3) for high risk human papillomavirus negative cervical cancer in Northeast Thailand. (PubMed id 21790234)1 Settheetham-Ishida W....Ishida T. (Asian Pac. J. Cancer Prev. 2011)
    752. Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer. (PubMed id 20852942)1 Kuasne H....CA^lus I.M. (Mol. Biol. Rep. 2011)
    753. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. (PubMed id 21612998)1 Gsur A....Micksche M. (Cancer Epidemiol 2011)
    754. DNA repair genes polymorphisms in multiple myeloma: no association with XRCC1 (Arg399Gln) polymorphism, but the XRCC4 (VNTR in intron 3 and G-1394T) and XPD (Lys751Gln) polymorphisms is associated with the disease in Turkish patients. (PubMed id 22183071)1 Cifci S....Pehlivan S. (Hematology 2011)
    755. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    756. XRCC1 polymorphisms and risk of papillary thyroid carcinoma in a Korean sample. (PubMed id 21860547)1 Ryu R.A....Ahn Y.H. (J. Korean Med. Sci. 2011)
    757. Polymorphisms of DNA repair and xenobiotic genes predispose to CpG island methylation in non-neoplastic gastric mucosa. (PubMed id 21435086)1 Tahara T....Arisawa T. (Helicobacter 2011)
    758. Polymorphisms in two DNA repair genes (XPD and XRCC1)--association with age related cataracts. (PubMed id 21245954)1 Padma G....Padma T. (Mol. Vis. 2011)
    759. Phase II study of biweekly S-1 and oxaliplatin combination chemotherapy in metastatic colorectal cancer and pharmacogenetic analysis. (PubMed id 20734048)1 Hong J....Kim T.Y. (Cancer Chemother. Pharmacol. 2011)
    760. No association between DNA repair gene (XPD, XRCC1, and XRCC4) polymorphisms and nonsyndromic microtia in Turkish patients. (PubMed id 21788800)1 Sever T....Bekerecioglu M. (Plast. Reconstr. Surg. 2011)
    761. Involvement of the XRCC1 Arg399Gln gene polymorphism in the development of cervical carcinoma. (PubMed id 21928248)1 Roszak A....Jagodzinski P.P. (Int. J. Biol. Markers 2011)
    762. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    763. Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study. (PubMed id 21622940)1 Roberts M.R....Freudenheim J.L. (Carcinogenesis 2011)
    764. [Predictive values of platinum-related gene polymorphisms in gastric cancer patients on oxaliplatin-based adjuvant chemotherapy]. (PubMed id 21418871)1 Liu Y.P....Liu B.R. (Zhonghua Yi Xue Za Zhi 2011)
    765. Polymorphisms of the DNA repair genes XRCC1 and ERCC4 are not associated with smoking- and drinking-dependent larynx cancer in a Polish population. (PubMed id 21423097)1 Krupa R....Morawiec-Sztandera A. (Exp. Oncol. 2011)
    766. XRCC1 polymorphisms and risk of nasopharyngeal carcinoma: a meta-analysis. (PubMed id 22296379)1 Huang G.L....He Z.W. (Asian Pac. J. Cancer Prev. 2011)
    767. Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. (PubMed id 21971103)1 Engin A.B....Engin A. (Arh Hig Rada Toksikol 2011)
    768. Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. (PubMed id 20368715)1 Cecchin E....Toffoli G. (Pharmacogenomics J. 2011)
    769. A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. (PubMed id 20644561)1 Ho-Pun-Cheung A....Lopez-Crapez E. (Pharmacogenomics J. 2011)
    770. Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair. (PubMed id 21353781)1 Weinfeld M....Glover J.N. (Trends Biochem. Sci. 2011)
    771. XRCC1 genetic polymorphism Arg399Gln and hepatocellular carcinoma risk: a meta-analysis. (PubMed id 21645210)1 Liu F....Xu M. (Liver Int. 2011)
    772. XRCC1 and base excision repair balance in response to nitric oxide. (PubMed id 22041025)1 Mutamba J.T....Engelward B.P. (DNA Repair (Amst.) 2011)
    773. Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. (PubMed id 21816818)1 Della-Maria J....Tomkinson A.E. (J. Biol. Chem. 2011)
    774. Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2. (PubMed id 21427728)1 Osorio A....BenA-tez J. (Br. J. Cancer 2011)
    775. Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. (PubMed id 21420246)1 Yin M....Wei Q. (Int. J. Radiat. Oncol. Biol. Phys. 2011)
    776. TP53 and XRCC1 polymorphisms and breast cancer prognosis: a case-case study. (PubMed id 21808882)1 Rodrigues M.S....Gallo C.V. (Clinics (Sao Paulo) 2011)
    777. Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to glioma. (PubMed id 22393975)1 Hu X.B....Huang Q.W. (Asian Pac. J. Cancer Prev. 2011)
    778. Multiple genetic polymorphisms in the prediction of clinical outcome of metastatic colorectal cancer patients treated with first-line FOLFOX-4 chemotherapy. (PubMed id 21057378)1 Huang M.Y....Wang J.Y. (Pharmacogenet. Genomics 2011)
    779. Pharmacogenetic interaction analysis for the efficacy of systemic treatment in metastatic colorectal cancer. (PubMed id 21048041)1 Pander J....Guchelaar H.J. (Ann. Oncol. 2011)
    780. An XRCC1 polymorphism is associated with the outcome of patients with lymphoma undergoing autologous stem cell transplant. (PubMed id 21463129)1 Guillem V.M....Tormo M. (amp 2011)
    781. XRCC1 gene variants and possible links with chromosome aberrations and micronucleus in active and passive smokers. (PubMed id 21843798)1 Chandirasekar R....Sasikala K. (Environ. Toxicol. Pharmacol. 2011)
    782. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (EMBO Rep. 2011)
    783. A functional -77T&gt;C polymorphism in XRCC1 is associated with risk of breast cancer. (PubMed id 20549339)1 Liu L....Lin D. (Breast Cancer Res. Treat. 2011)
    784. XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis. (PubMed id 21647176)1 Wei B....Yan Z. (Prostate Cancer Prostatic Dis. 2011)
    785. Association between polymorphisms of XRCC1, p53 and MDR1 genes, the expression of their protein products and prognostic significance in human breast cancer. (PubMed id 22129893)1 RybA!rovA! S....Mirossay L. (Med. Sci. Monit. 2011)
    786. Pharmacogenetic study in rectal cancer patients treated with preoperative chemoradiotherapy: polymorphisms in thymidylate synthase, epidermal growth factor receptor, GSTP1, and DNA repair genes. (PubMed id 21570215)1 PA!ez D....Baiget M. (Int. J. Radiat. Oncol. Biol. Phys. 2011)
    787. Polymorphisms of the DNA repair genes XPD and XRCC1 and the risk of age-related cataract development in Han Chinese. (PubMed id 21599457)1 Luo Y.F....Qi Y.H. (Curr. Eye Res. 2011)
    788. 8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes. (PubMed id 21376741)1 Janik J....Speina E. (Mutat. Res. 2011)
    789. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. (PubMed id 21825151)1 Kang H.C.... Dawson T.M. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    790. Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of articledeveloping erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery. (PubMed id 21749698)1 Falvo E....PinnarA^ P. (BMC Cancer 2011)
    791. Association between genetic polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT genes and radiosensitivity in breast cancer patients. (PubMed id 20708344)1 Mangoni M....Gorini G. (Int. J. Radiat. Oncol. Biol. Phys. 2011)
    792. DNA repair gene XRCC1 polymorphisms and the risk of asthma in a Turkish population. (PubMed id 20819327)1 Batar B....Kanigur-Sultuybek G. (Allergy Asthma Proc 2010)
    793. Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. (PubMed id 20957144)1 Ji G....Wang X. (PLoS ONE 2010)
    794. Influence of genetic polymorphisms on frequency of micronucleated buccal epithelial cells in leukoplakia patients. (PubMed id 20850372)1 Mahimkar M.B....Patil T. (Oral Oncol. 2010)
    795. Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis. (PubMed id 20805321)1 Bompard G.... Morin N. (J. Cell Biol. 2010)
    796. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    797. XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair. (PubMed id 20471329)1 Parsons J.L....Dianov G.L. (DNA Repair (Amst.) 2010)
    798. Nucleotide excision repair gene polymorphisms may predict acute toxicity in patients treated with chemoradiotherapy for bladder cancer. (PubMed id 21047201)1 Sakano S....Matsuyama H. (Pharmacogenomics 2010)
    799. Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. (PubMed id 20466601)1 Akbari M....Otterlei M. (DNA Repair (Amst.) 2010)
    800. Smoking, DNA adducts and number of risk DNA repair alleles in lung cancer cases, in subjects with benign lung diseases and in controls. (PubMed id 20976253)1 Peluso M....Puntoni R. (J Nucleic Acids 2010)
    801. Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer. (PubMed id 20495366)1 Gao R....Figg W.D. (amp 2010)
    802. Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. (PubMed id 20302655)1 Lee C.H....Shieh Y.S. (Mol. Cancer 2010)
    803. [Genetic polymorphism of XRCC1 associated with susceptibility of chromosomal damage in workers exposed by 1,3-butadiene]. (PubMed id 21351625)1 Wang Q....Xia Z. (Wei Sheng Yan Jiu 2010)
    804. Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. (PubMed id 21037106)1 Brevik A....Stern M.C. (amp 2010)
    805. Association of XRCC1 variants with acute skin reaction after radiotherapy in breast cancer patients. (PubMed id 21204762)1 Zhou L....Hu Y. (amp 2010)
    806. Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis. (PubMed id 20981350)1 Kiyohara C....Nakanishi Y. (J Nucleic Acids 2010)
    807. Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase beta binding affinity. (PubMed id 20351257)1 Cuneo M.J. and London R.E. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    808. [Meta-analysis of the relationship between polymorphisms of 399 point of X-ray repair cross complementing gene group 1 and hepatocellular carcinoma]. (PubMed id 21351626)1 Zhang H....Zhang J. (Wei Sheng Yan Jiu 2010)
    809. No association between XRCC1 polymorphisms and survival in non-small-cell lung cancer patients treated with platinum-based chemotherapy. (PubMed id 20814250)1 Yuan P....Lin D. (amp 2010)
    810. p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1. (PubMed id 20303835)1 Cazzalini O....Prosperi E. (DNA Repair (Amst.) 2010)
    811. Genetics polymorphism in DNA repair genes by base excision repair pathway (XRCC1) and homologous recombination (XRCC2 and RAD51) and the risk of breast carcinoma in the Polish population. (PubMed id 21290343)1 Romanowicz H....Kulig A. (Pol J Pathol 2010)
    812. SIRT1 deacetylates APE1 and regulates cellular base excision repair. (PubMed id 19934257)2 Yamamori T.... Irani K. (Nucleic Acids Res. 2010)
    813. Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population. (PubMed id 20385586)1 Berquist B.R....Wilson D.M. (Nucleic Acids Res. 2010)
    814. [Association between genetic polymorphisms of ERCC1, XRCC1, GSTP1 and survival of advanced gastric cancer patients treated with oxaliplatin/5-Fu-based chemotherapy]. (PubMed id 21029695)1 Liang J....Jiang T. (Zhonghua Zhong Liu Za Zhi 2010)
    815. Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients. (PubMed id 20439344)1 Sun Z....Yang P. (Ann. Oncol. 2010)
    816. Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. (PubMed id 20720310)4 Jelonek K....Widlak P. (J. Appl. Genet. 2010)
    817. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    818. Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. (PubMed id 20403997)1 Lipkin S.M....Gruber S.B. (Cancer Prev Res (Phila) 2010)
    819. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    820. [Genetic susceptibility of DNA damage induced by vinyl chloride monomer exposure]. (PubMed id 20426969)1 Ji F....Xia Z.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2010)
    821. Glioma risk associates with polymorphisms of DNA repair genes, XRCC1 and PARP1. (PubMed id 20868244)1 Yosunkaya E....Kanigur-Sultuybek G. (Br J Neurosurg 2010)
    822. Smoking and selected DNA repair gene polymorphisms in controls: systematic review and meta-analysis. (PubMed id 20935063)1 Hodgson M.E....Millikan R.C. (amp 2010)
    823. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    824. The Arg194Trp polymorphism in the X-ray repair cross-complementing group 1 gene as a potential risk factor of oral cancer: a meta-analysis. (PubMed id 19713684)1 Zhou C....Wang Z. (Tohoku J. Exp. Med. 2009)
    825. Haplotypes of XRCC1 and survival outcome in patients with metastatic breast cancer. (PubMed id 19127428)1 Bewick M.A....Lafrenie R.M. (Breast Cancer Res. Treat. 2009)
    826. Localization of X-ray cross complementing gene 1 protein in the nuclear matrix is controlled by casein kinase II-dependent phosphorylation in response to oxidative damage. (PubMed id 19596613)1 Kubota Y....Horiuchi S. (DNA Repair (Amst.) 2009)
    827. JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks. (PubMed id 19208635)1 Wang S....Zhou J. (Nucleic Acids Res. 2009)
    828. Genetic variants of the XRCC1 gene and susceptibility to esophageal cancer: a meta-analysis. (PubMed id 19436829)4 Yin M....Wei Q. (Int J Clin Exp Med 2009)
    829. Association between genetic polymorphism of XRCC1 Arg194Trp and risk of schizophrenia. (PubMed id 19631990)1 Derakhshandeh S....Saadat M. (Psychiatry Res 2009)
    830. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    831. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    832. Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. (PubMed id 20559012)4 Stern M.C....Yu M.C. (J Nutrigenet Nutrigenomics 2009)
    833. DNA damage and related modifier genes in Italian cystic fibrosis patients. (PubMed id 20140303)4 Sterpone S....Cozzi R. (Biol. Res. 2009)
    834. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. (PubMed id 19633665)1 Lee Y....McKinnon P.J. (Nat. Neurosci. 2009)
    835. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. (PubMed id 19661379)1 Ahel D....Boulton S.J. (Science 2009)
    836. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    837. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    838. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. (PubMed id 18971944)1 Chou W.C....Shen C.Y. (EMBO J. 2008)
    839. Restoration of nuclear-import failure caused by triple A syndrome and oxidative stress. (PubMed id 18662670)1 Kiriyama T....Ueno S. (Biochem. Biophys. Res. Commun. 2008)
    840. CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. (PubMed id 18313385)1 Parsons J.L....Dianov G.L. (Mol. Cell 2008)
    841. Genetic polymorphisms and head and neck cancer outcomes: a review. (PubMed id 18349267)1 Hopkins J....Liu G. (amp 2008)
    842. The difference between pre-B cell acute lymphoblastic leukemia and Burkitt lymphoma in relation to DNA damage repair gene polymorphisms in childhood. (PubMed id 18608862)4 Celkan T....Alhaj S. (amp 2008)
    843. APE1 and XRCC3 polymorphisms and myocardial infarction. (PubMed id 18712175)1 Tekeli A....Isbir T. (In Vivo 2008)
    844. hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo. (PubMed id 17971348)1 Mateuca R.A....Kirsch-Volders M. (Mutagenesis 2008)
    845. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    846. Human DNA polymerase iota protects cells against oxidative stress. (PubMed id 18923427)1 Petta T.B....Kannouche P. (EMBO J. 2008)
    847. Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India. (PubMed id 17952468)1 Sreeja L....Ankathil R. (J. Cancer Res. Clin. Oncol. 2008)
    848. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    849. Conformational effects of a common codon 399 polymorphism on the BRCT1 domain of the XRCC1 protein. (PubMed id 17899335)1 Monaco R....Brandt-Rauf P.W. (Protein J. 2007)
    850. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    851. Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner. (PubMed id 17643379)1 Moser J....Fousteri M.I. (Mol. Cell 2007)
    852. [Single nucleotide polymorphism of XRCC1 gene in Bouyei and Shui populations]. (PubMed id 18095605)1 Zou Y....Chen W. (Sichuan Da Xue Xue Bao Yi Xue Ban 2007)
    853. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    854. Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER. (PubMed id 16442856)1 Petermann E....Oei S.L. (DNA Repair (Amst.) 2006)
    855. Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair. (PubMed id 16543152)1 Heale J.T....Yokomori K. (Mol. Cell 2006)
    856. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    857. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. (PubMed id 16964241)1 Ahel I.... West S.C. (Nature 2006)
    858. Rapid analysis of XRCC1 polymorphisms using real-time polymerase chain reaction. (PubMed id 16542819)1 Schneider J....Helmig S. (Mol. Cell. Probes 2006)
    859. Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S.... Mann M. (Nature 2005)
    860. Specificity of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein. (PubMed id 15987676)1 Beernink P.T....Thelen M.P. (J. Biol. Chem. 2005)

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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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