Aliases for XRCC1 Gene
External Ids for XRCC1 Gene
Previous Symbols for XRCC1 Gene
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
GeneCards Summary for XRCC1 Gene
XRCC1 (X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 1) is a Protein Coding gene. Diseases associated with XRCC1 include cardia cancer and gastric cardia carcinoma. Among its related pathways are Cell Cycle / Checkpoint Control and Chks in Checkpoint Regulation. GO annotations related to this gene include damaged DNA binding. An important paralog of this gene is ENSG00000268361.
UniProtKB/Swiss-Prot for XRCC1 Gene
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents