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Aliases for XRCC1 Gene

Aliases for XRCC1 Gene

  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 1 2 3
  • X-Ray Repair Cross-Complementing Protein 1 3 4
  • DNA Repair Protein XRCC1 3
  • RCC 3

External Ids for XRCC1 Gene

Previous Symbols for XRCC1 Gene

  • RCC

Summaries for XRCC1 Gene

Entrez Gene Summary for XRCC1 Gene

  • The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

GeneCards Summary for XRCC1 Gene

XRCC1 (X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 1) is a Protein Coding gene. Diseases associated with XRCC1 include cardia cancer and gastric cardia carcinoma. Among its related pathways are Cell Cycle / Checkpoint Control and Chks in Checkpoint Regulation. GO annotations related to this gene include damaged DNA binding. An important paralog of this gene is ENSG00000268361.

UniProtKB/Swiss-Prot for XRCC1 Gene

  • Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents

Gene Wiki entry for XRCC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XRCC1 Gene

Genomics for XRCC1 Gene

Genomic Location for XRCC1 Gene

Start:
43,543,040 bp from pter
End:
43,580,473 bp from pter
Size:
37,434 bases
Orientation:
Minus strand

Genomic View for XRCC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XRCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XRCC1 Gene

Regulatory Elements for XRCC1 Gene

Proteins for XRCC1 Gene

  • Protein details for XRCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18887-XRCC1_HUMAN
    Recommended name:
    DNA repair protein XRCC1
    Protein Accession:
    P18887
    Secondary Accessions:
    • Q6IBS4
    • Q9HCB1

    Protein attributes for XRCC1 Gene

    Size:
    633 amino acids
    Molecular mass:
    69477 Da
    Quaternary structure:
    • Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.

    Three dimensional structures from OCA and Proteopedia for XRCC1 Gene

neXtProt entry for XRCC1 Gene

Proteomics data for XRCC1 Gene at MOPED

Post-translational modifications for XRCC1 Gene

  • Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
  • Sumoylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr296, Thr440, Ser446, Ser447, and Thr453

Other Protein References for XRCC1 Gene

No data available for DME Specific Peptides for XRCC1 Gene

Domains for XRCC1 Gene

Protein Domains for XRCC1 Gene

Suggested Antigen Peptide Sequences for XRCC1 Gene

Graphical View of Domain Structure for InterPro Entry

P18887

UniProtKB/Swiss-Prot:

XRCC1_HUMAN
Domain:
  • Contains 2 BRCT domains.:
    • P18887
genes like me logo Genes that share domains with XRCC1: view

No data available for Gene Families for XRCC1 Gene

Function for XRCC1 Gene

Molecular function for XRCC1 Gene

GENATLAS Biochemistry: repair X-ray defect,complementing defect in CHO cells,1,involved in single-strand DNA break rejoining,susceptibility gene for squamous cell carcinoma of the head and neck
UniProtKB/Swiss-Prot Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents

Gene Ontology (GO) - Molecular Function for XRCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding IEA --
GO:0005515 protein binding IPI 14755728
GO:0019899 enzyme binding IPI 8532526
genes like me logo Genes that share ontologies with XRCC1: view
genes like me logo Genes that share phenotypes with XRCC1: view

Animal Models for XRCC1 Gene

MGI Knock Outs for XRCC1:

miRNA for XRCC1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for XRCC1 Gene

Localization for XRCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRCC1 Gene

Nucleus. Note=Accumulates at sites of DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XRCC1 Gene COMPARTMENTS Subcellular localization image for XRCC1 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for XRCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with XRCC1: view

Pathways for XRCC1 Gene

genes like me logo Genes that share pathways with XRCC1: view

Pathways by source for XRCC1 Gene

1 Qiagen pathway for XRCC1 Gene
2 Cell Signaling Technology pathways for XRCC1 Gene

Gene Ontology (GO) - Biological Process for XRCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000012 single strand break repair IEA --
GO:0001666 response to hypoxia IEA --
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006974 cellular response to DNA damage stimulus --
genes like me logo Genes that share ontologies with XRCC1: view

Compounds for XRCC1 Gene

(48) Novoseek inferred chemical compound relationships for XRCC1 Gene

Compound -log(P) Hits PubMed IDs
polynucleotide 65.7 11
8-oxoguanine 63.6 7
lead chromate 59.8 6
vinylchloride 57.1 15
methylmethanesulfonate 51.9 7

(7) PharmGKB related drug/compound annotations for XRCC1 Gene

genes like me logo Genes that share compounds with XRCC1: view

Transcripts for XRCC1 Gene

Unigene Clusters for XRCC1 Gene

X-ray repair complementing defective repair in Chinese hamster cells 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XRCC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5: - - - -
SP6:
SP7: - - - -
SP8:

Relevant External Links for XRCC1 Gene

GeneLoc Exon Structure for
XRCC1
ECgene alternative splicing isoforms for
XRCC1

Expression for XRCC1 Gene

mRNA expression in normal human tissues for XRCC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XRCC1 Gene

SOURCE GeneReport for Unigene cluster for XRCC1 Gene Hs.98493

genes like me logo Genes that share expressions with XRCC1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for XRCC1 Gene

Orthologs for XRCC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for XRCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XRCC1 35
  • 99.04 (n)
  • 98.71 (a)
XRCC1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XRCC1 35
  • 86.48 (n)
  • 88.11 (a)
XRCC1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XRCC1 35
  • 87.65 (n)
  • 89.35 (a)
XRCC1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xrcc1 35
  • 84.79 (n)
  • 86.49 (a)
Xrcc1 16
Xrcc1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Xrcc1 35
  • 84.95 (n)
  • 86.49 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia xrcc1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia xrcc1 35
  • 61.48 (n)
  • 60.33 (a)
zebrafish
(Danio rerio)
Actinopterygii xrcc1 35
  • 57.71 (n)
  • 54.26 (a)
xrcc1 36
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta XRCC1 36
  • 29 (a)
OneToMany
XRCC1 37
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for XRCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRCC1 Gene

ENSEMBL:
Gene Tree for XRCC1 (if available)
TreeFam:
Gene Tree for XRCC1 (if available)

Paralogs for XRCC1 Gene

Paralogs for XRCC1 Gene

genes like me logo Genes that share paralogs with XRCC1: view

Variants for XRCC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC1 Gene

P18887-XRCC1_HUMAN
Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage

Sequence variations from dbSNP and Humsavar for XRCC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3547 -- 43,543,398(+) CAGGC(C/T)TGCGG reference, synonymous-codon
rs25474 - 43,545,898(-) AGACC(C/T)GTATG reference, missense
rs25475 -- 43,545,795(-) CCCTC(C/T)TGAAG intron-variant
rs25476 -- 43,545,729(-) CACTG(A/C)TGCCC intron-variant
rs25477 -- 43,545,722(-) GCCCC(C/T)GTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XRCC1 Gene

Variant ID Type Subtype PubMed ID
nsv912107 CNV Loss 21882294

Relevant External Links for XRCC1 Gene

HapMap Linkage Disequilibrium report
XRCC1
Human Gene Mutation Database (HGMD)
XRCC1

Disorders for XRCC1 Gene

(45) Novoseek inferred disease relationships for XRCC1 Gene

Disease -log(P) Hits PubMed IDs
xeroderma pigmentosum 73.7 26
cancer 60.3 68
cancer lung 58.1 60
nsclc 50.5 23
bladder cancer 46.2 27

Relevant External Links for XRCC1

Genetic Association Database (GAD)
XRCC1
Human Genome Epidemiology (HuGE) Navigator
XRCC1
genes like me logo Genes that share disorders with XRCC1: view

No data available for UniProtKB/Swiss-Prot for XRCC1 Gene

Publications for XRCC1 Gene

  1. The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. (PMID: 11782372) Nelson H.H. … Karagas M.R. (Cancer Res. 2002) 3 4 23 48
  2. A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer. (PMID: 11712813) Stoehlmacher J. … Lenz H.J. (Anticancer Res. 2001) 3 23 48
  3. Genetic polymorphism of XRCC1 and lung cancer risk among African-Americans and Caucasians. (PMID: 11714530) David-Beabes G.L. … London S.J. (Lung Cancer 2001) 3 23 48
  4. Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer. (PMID: 11815397) Park J.Y. … Jung T.H. (Cancer Epidemiol. Biomarkers Prev. 2002) 3 23 48
  5. XRCC1 polymorphisms and head and neck cancer. (PMID: 11867203) Olshan A.F. … Bell D.A. (Cancer Lett. 2002) 3 23 48

Products for XRCC1 Gene

  • Addgene plasmids for XRCC1

Sources for XRCC1 Gene

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