XRCC1 Gene
protein-coding GIFtS: 64
GCID: GC19M044047
|
|
X-ray repair complementing defective repair in Chinese hamster...
(Previous symbol: RCC)
| |
Aliases
for XRCC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 11 2 | | RCC1 2 | | X-Ray Repair Cross-Complementing Protein 12 3 | | DNA Repair Protein XRCC12 | | X-Ray-Repair, Complementing Defective, Repair In Chinese Hamster2 |
Export aliases for XRCC1 gene to outside databasesPrevious GC identifers: GC19M044692 GC19M044439 GC19M048723 GC19M048739 GC19M040478 |
Summaries
for XRCC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XRCC1:
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure toionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly(ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processingduring meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated withcancer in patients of varying radiosensitivity. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizingradiation and alkylating agents
Gene Wiki entry for XRCC1
|
Genomic Views
for XRCC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XRCC1 gene promoter:
STAT1 STAT1beta CUTL1 LCR-F1 AP-2gamma NF-kappaB COMP1 c-Myb NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for XRCC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XRCC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.2XRCC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M044047: view genomic region
(about GC identifiers)
Start:
|
44,047,464 bp from pter |
End:
|
44,079,730 bp from pter |
Size:
|
32,267 bases |
Orientation:
|
minus strand |
|
Proteins
for XRCC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887 (See
protein sequence)Recommended Name: DNA repair protein XRCC1 Size: 633 amino acids; 69477 Da
Subunit: Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3).Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with theacetylated form of APEX1
Subcellular location: Nucleus. Note=Accumulates at sites of DNA damage
6/8 PDB 3D structures from  and Proteopedia  for XRCC1 (see all 8):1CDZ (3D)
1XNA (3D)
1XNT (3D)
2D8M (3D)
2W3O (3D)
3K75 (3D)
Secondary accessions: Q6IBS4 Q9HCB1Explore the universe of human proteins at neXtProt for XRCC1: NX_P18887
Post-translational modifications:
Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF1
Sumoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P18887
XRCC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006288.2
ENSEMBL proteins: ENSP00000262887 ENSP00000443671 Reactome Protein details: P18887
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
XRCC1 for ontologies About GeneDecksing
XRCC1 Antibody Products:
Assay Products for XRCC1: |
Protein
Domains /
Families
for XRCC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XRCC1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P18887ProtoNet protein and cluster: P18887 2 Blocks protein families: IPB001357 BRCT domain IPB002706 DNA-repair protein Xrcc1
UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887Similarity: Contains 2 BRCT domains |
Function
for XRCC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizingradiation and alkylating agents Genatlas biochemistry entry for XRCC1:repair X-ray defect,complementing defect in CHO cells,1,involved in single-strand DNA break rejoining,susceptibilitygene for squamous cell carcinoma of the head and neck
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XRCC1 (NM_006297) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
XRCC1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for XRCC1:
Animal Models:
Mouse knock-out Xrcc1tm1Rpe for XRCC1
9 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Xrcc1):
XRCC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for XRCC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Resolution of Abasic Sites (AP sites) | | | 2 | DNA Damage | | | 3 | Cell Cycle / Checkpoint Control | | | 4 | Meiosis | | | 5 | E2F transcription factor network | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for XRCC1
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for XRCC1
2 
Cell Signaling Technology (CST) Pathways for XRCC1
2  BioSystems Pathways for XRCC1
4 
Reactome Pathways for XRCC1
1 
Kegg Pathway (Kegg details for XRCC1):
XRCC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XRCC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/52 Interacting proteins for XRCC1 (P188871, 2, 3 ENSP000002628874) via UniProtKB, MINT, STRING, and/or I2D (see all 52)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| APTX | Q7Z2E31, 2, 3, ENSP000004008064 | EBI-947466,EBI-847814 MINT-2864208 MINT-51181 MINT-51153 MINT-51140 MINT-51142 MINT-51182 MINT-51154 MINT-51139 MINT-2864189 MINT-51230 I2D:
score=5 STRING: ENSP00000400806 | | CHEK2 | O960172, 3, ENSP000003720234 | MINT-7295039 MINT-7294980 MINT-7294997 MINT-7294787 MINT-7295015 MINT-7295027 MINT-7294958 MINT-7294756 I2D:
score=1 STRING: ENSP00000372023 | | CCNO | P226742, 3, ENSP000002825724 | MINT-7294905 MINT-7294888 I2D:
score=1 STRING: ENSP00000282572 | | POLI | Q9UNA42, 3, ENSP000002178004 | MINT-7296097 MINT-7296110 I2D:
score=1 STRING: ENSP00000217800 | | H2AFX | P161042, 3, ENSP000003643104 | MINT-7543857 I2D:
score=1 STRING: ENSP00000364310 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
XRCC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for XRCC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
XRCC1 for compounds About GeneDecksing
 Browse Tocris compounds for XRCC1
10/48 Novoseek chemical compound relationships for XRCC1 gene (see all 48) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| polynucleotide |
65.7 |
12 |
11163244 (3), 19910369 (2), 17650498 (1), 17353262 (1) (see all 8) |
| 8-oxoguanine |
63.6 |
8 |
18349297 (1), 12933815 (1), 15927541 (1), 18393249 (1) (see all 7) |
| lead chromate |
59.8 |
8 |
16714390 (3), 16597656 (3) |
| vinylchloride |
57.1 |
21 |
12739102 (4), 12010862 (3), 16881598 (2), 17555083 (2) (see all 7) |
| methylmethanesulfonate |
51.9 |
10 |
15867196 (2), 17603793 (1), 15781218 (1), 11909950 (1) (see all 6) |
| mspi |
51.1 |
5 |
18364571 (1), 19176223 (1), 17418242 (1), 14639127 (1) |
| methoxyamine |
47.3 |
1 |
11585361 (1) |
| oxaliplatin |
44.2 |
6 |
17273745 (2), 15213713 (1), 17009149 (1), 11712813 (1) |
| adpribose |
41.4 |
9 |
14500814 (5), 16963444 (2), 11016934 (1), 12198176 (1) |
| gsts |
36.4 |
1 |
11708327 (1) |
7 PharmGKB related drug/compound annotations for XRCC1 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about XRCC1
|
Transcripts
for XRCC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XRCC1 gene: NM_006297.2 Unigene Cluster for XRCC1: X-ray repair complementing defective repair in Chinese hamster cells 1 Hs.98493 [show with all ESTs]Unigene Representative Sequence: NM_0062972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262887(uc002owt.2 uc010xwp.1) ENST00000543982
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XRCC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XRCC1 (NM_006297) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XRCC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XRCC1 |
Additional cDNA sequence: AB208781.1 AK293542.1 AK300163.1 AK315332.1 BC023593.2 CR456728.1 13 DOTS entries: DT.452311 DT.91761768 DT.100773970 DT.100027795 DT.100782706 DT.100782718 DT.100782719 DT.87016286 DT.100637811 DT.95107355 DT.121484346 DT.87016288 DT.91724728 24/374 AceView cDNA sequences (see all 374): BE044126 BX452522 AI206971 F08201 BM928576 AI983314 CR600609 BQ057273 BM698936 CR617745 BQ682697 BG258140 AI424752 CR614880 BQ056064 BM451621 AL526899 BF940405 AW613956 BE252183 BM831688 BQ066716 BM711287 BQ643143
GeneLoc Exon Structure
8 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC1 (see first 5) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP6: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP7: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP8: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for XRCC1
|
Expression
for XRCC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XRCC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGGGCCAG
About this image
See XRCC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XRCC1
SOURCE GeneReport for Unigene cluster: Hs.98493
SABiosciences Expression via Pathway-Focused PCR Arrays including XRCC1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XRCC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XRCC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XRCC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XRCC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XRCC1 |
Orthologs
for XRCC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for XRCC1 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
XRCC16 |
-- |
55(a) |
1 → many |
LGf(1127269-1140959) |
African clawed frog
(Xenopus laevis) |
Amphibia |
xrcc1-prov2 |
x-ray repair cross-complementing group 1 protein |
76.58(n) |
|
BC045032.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
xrcc11 |
X-ray repair complementing defective repair in Chinese more |
58.35(n)
55.28(a) |
|
445480 NM_001003988.1 NP_001003988.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
XRCC13 |
nucleotide-excision repair |
40(a) |
|
4F5 -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATXRCC16 |
DNA-repair protein XRCC1 |
20(a) |
1 → many |
1(30235164-30238535) |
rice
(Oryza sativa) |
Liliopsida |
-- |
BRCA1 C Terminus domain containing protein, expres... |
22(a) |
1 → many |
6(2328884-2333475) |
ENSEMBL Gene Tree for XRCC1 (if available)
TreeFam Gene Tree for XRCC1 (if available) |
Paralogs
for XRCC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XRCC1 gene
- LOC1001333152
XRCC1 for paralogs About GeneDecksing
|
Genomic Variants
for XRCC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887Polymorphism: Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XRCC1 (44047464 - 44079730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for XRCC1: --
Human Gene Mutation Database (HGMD): XRCC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XRCC1 |
|
Disorders
/ Diseases
for XRCC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XRCC1 for disorders About GeneDecksing
OMIM gene information: 194360
OMIM disorders: --
20/139  diseases for XRCC1 (see all 139): About MalaCardsopen-angle glaucoma xeroderma pigmentosum, group d oculomotor apraxia xeroderma pigmentosum
ehlers-danlos syndrome triple-a syndrome diffuse large b-cell lymphoma primary open angle glaucoma
cervical intraepithelial neoplasia age related macular degeneration graft versus host disease b-cell lymphomas
pre-eclampsia acoustic neuroma mutagen sensitivity testicular germ cell tumor
squamous cell carcinoma soft tissue sarcoma type 2 diabetes mellitus apraxia
6 diseases from the University of Copenhagen DISEASES database for XRCC1:Xeroderma pigmentosum Lung cancer Breast cancer Carcinoma
Urinary bladder cancer Colorectal cancer 10/45 Novoseek disease relationships for XRCC1 gene (see all 45) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| xeroderma pigmentosum |
73.7 |
28 |
11016934 (1), 17593927 (1), 19109787 (1), 19657998 (1) (see all 26) |
| cancer |
60.3 |
79 |
16172217 (6), 15896924 (4), 16550161 (4), 16137195 (3) (see all 48) |
| cancer lung |
58.1 |
77 |
18999926 (4), 17417947 (4), 19481337 (4), 12618330 (3) (see all 34) |
| nsclc |
50.5 |
31 |
19958624 (3), 19683826 (2), 15534883 (2), 16157195 (2) (see all 13) |
| bladder cancer |
46.2 |
30 |
18272472 (5), 18336890 (3), 20514470 (2), 12223443 (2) (see all 15) |
| neck cancer |
44.8 |
7 |
19846968 (2), 11867203 (1), 18833034 (1), 19643719 (1) |
| carcinoma squamous cell |
44.7 |
19 |
17614107 (2), 19444915 (2), 19230024 (2), 1574572 (1) (see all 15) |
| breast cancer |
44.6 |
106 |
16457697 (6), 15666192 (5), 18481169 (5), 15734955 (4) (see all 42) |
| genetic susceptibility |
43.6 |
5 |
15666192 (1), 15252855 (1), 17385092 (1), 19673050 (1) (see all 5) |
| colorectal cancer |
43.3 |
30 |
18806752 (4), 15800946 (3), 20033188 (3), 17009149 (3) (see all 13) |
Genetic Association Database (GAD): XRCC1
Human Genome Epidemiology (HuGE) Navigator: XRCC1 (589 documents)
Export disorders for XRCC1 gene to outside databases
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Publications
for XRCC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for XRCC1 gene, integrated from 9 sources (see all 885):
(articles sorted by number of sources associating them with XRCC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. (PubMed id 2247054)1, 2, 3 Thompson L.H.... Carrano A.V. (1990)
- Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (Codon 280). (PubMed id 16172217)1, 4, 9 Majumder M....Roy B. (2005)
- A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. (PubMed id 12183419)1, 4, 9 Duell E.J....Kelsey K.T. (2002)
- XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage. (PubMed id 16397295)1, 2, 9 Levy N....Menissier-de Murcia J. (2006)
- [Association of genetic polymorphism of XRCC1 with susceptibility to acute childhood leukemia] (PubMed id 16111035)1, 4, 9 Zhu R....Xia Z. (2005)
- The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms. (PubMed id 15534883)1, 4, 9 Liu G....Christiani D.C. (2004)
- Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients. (PubMed id 15665590)1, 4, 9 Deligezer U. and Dalay N. (2004)
- A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. (PubMed id 14679022)1, 4, 9 Han J....Hunter D.J. (2003)
- The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. (PubMed id 11782372)1, 2, 9 Nelson H.H.... Karagas M.R. (2002)
- Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. (PubMed id 19155274)1, 2, 9 Ali A.A....Oliver A.W. (2009)
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External Searches for XRCC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing XRCC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
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Other Databases showing XRCC1 gene
(According to HUGE)
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| -- |
Specialized Databases showing XRCC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for XRCC1 gene:
Search GeneIP for patents involving XRCC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XRCC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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