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XRCC1 Gene

protein-coding GIFtS: 69

GC19M048739

X-ray repair complementing defective repair in Chinese hamster cells 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RCC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
RCC ^²

Descriptions
DNA repair protein XRCC1 ^²
X-ray repair complementing defective repair in Chinese hamster cells 1 ^²
X-ray repair cross complementing protein 1 ^²
X-ray repair cross-complementing protein 1 ^³
X-ray-repair, complementing defective, repair in Chinese hamster ^²

External Ids
HGNC: 12828¹
Entrez Gene: 7515²
UniProtKB: P18887³
Ensembl: ENSG00000073050⁷

Search outside databases for aliases for XRCC1 gene

Previous GC identifers: GC19M044692 GC19M044439 GC19M048723

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XRCC1:

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks

formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA

ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision

repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ

cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of

varying radiosensitivity. [provided by RefSeq]

UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887

Function: Corrects defective DNA strand-break repair and sister chromatid exchange following

treatment with ionizing radiation and alkylating agents

Gene Wiki entry for XRCC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XRCC1 gene

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.2

XRCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M048739: (about GC identifiers)

Start:	48,739,304 bp from pter
End:	48,771,555 bp from pter
Size:	32,252 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887 (See protein sequence)

Recommended Name: DNA repair protein XRCC1

Size: 633 amino acids; 69526 Da

Subunit: Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA

ligase III (LIG3). Interacts with APTX and APLF

Subcellular location: Nucleus. Note=Accumulates at sites of DNA damage

PDB structures from and Proteopedia :

1CDZ (3D)

1XNA (3D)

1XNT (3D)

2D8M (3D)

2W3O (3D)

Secondary accessions: Q9HCB1

Post-translational modifications:

Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction

with APTX and APLF¹

Sumoylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006288.2

ENSEMBL proteins:

ENSP00000262887

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XRCC1)
	Human Recombinant Proteins from Abnova (XRCC1)

OriGene Purified Recombinant Human Protein: XRCC1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	8978692

About this table

Antibodies for XRCC1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of XRCC1
	Sigma-Aldrich Antibodies for XRCC1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for XRCC1
	Antibodies from Abcam (XRCC1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XRCC1)
	Novus Biologicals Antibodies for XRCC1

Assays for XRCC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18887

ProtoNet protein and cluster: P18887

2 Blocks protein families:

IPB001357 BRCT domain

IPB002706 DNA-repair protein Xrcc1

UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887

Similarity: Contains 2 BRCT domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRCC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XRCC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006297

Applied Biosystems Silencer® siRNAs for XRCC1

Sigma-Aldrich siRNA and siRNA Panels for XRCC1

Sigma-Aldrich shRNA Panels and shRNA for XRCC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XRCC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006297
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006297
untagged cDNA clone in CMV expression vector: NM_006297

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006297

UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887

Function: Corrects defective DNA strand-break repair and sister chromatid exchange following

treatment with ionizing radiation and alkylating agents

Genatlas biochemistry entry for XRCC1:

repair X-ray defect,complementing defect in CHO cells,1,involved in single-strand DNA break

rejoining,susceptibility gene for squamous cell carcinoma of the head and neck

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Xrcc1):

embryogenesis

growth/size

lethality-prenatal/perinatal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003684	damaged DNA binding	IEA	--
GO:0005515	protein binding	IPI	14755728 15044383

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for XRCC1

5/64 Interacting proteins for XRCC1 (P18887^{1, 2} ENSP00000262887³) via UniProtKB, MINT, and/or STRING (see all 64 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APTX	Q7Z2E3², ENSP00000369147³	MINT-2864208 MINT-51181 MINT-51153 MINT-51140 MINT-51142 MINT-51182 MINT-51154 MINT-51139 MINT-51230 MINT-2864189 STRING (score=.999)
PNKP	Q96T60¹, ENSP00000323511³	EBI-947466, EBI-1045072 STRING (score=.999)
PARP1	P09874², ENSP00000355759³	MINT-4790124 STRING (score=.998)
CSNK2A1P	P68400², ENSP00000371400³	MINT-51183 STRING (score=.989)
LIG3	P49916¹^,², ENSP00000367787³	EBI-947466, EBI-1753381 MINT-4790124 EBI-947466, EBI-1753381 MINT-4790124 STRING (score=.999)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000012	single strand break repair	IEA	--
GO:0006974	response to DNA damage stimulus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XRCC1
10/27 Novoseek chemical compound relationships for XRCC1 gene (see all 27 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
polynucleotide	64.36	9	11163244 (3), 17650498 (1), 17353262 (1), 12198176 (1) (see all 6)
8-oxoguanine	64.17	7	18349297 (1), 12933815 (1), 15927541 (1), 18393249 (1) (see all 6)
lead chromate	62.10	8	16714390 (3), 16597656 (3)
vinylchloride	56.42	20	12739102 (4), 12010862 (3), 16881598 (2), 14602524 (2) (see all 6)
mspi	53.59	5	18364571 (1), 19176223 (1), 17418242 (1), 14639127 (1)
methoxyamine	49.98	1	11585361 (1)
diepoxybutane	37.60	2	17078101 (1)
platinum	24.72	1	11712813 (1)
gsts	24.71	1	11708327 (1)
mnng	23.77	2	16963444 (1), 12773770 (1)

About this table

1 PharmGKB drug compound relationship for XRCC1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
alcohol	PD	12042672

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XRCC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XRCC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006297

Sigma-Aldrich siRNA and siRNA Panels for XRCC1

Sigma-Aldrich shRNA Panels and shRNA for XRCC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006297

REFSEQ mRNAs for XRCC1 gene:

NM_006297.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006297

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006297
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006297
                                 untagged cDNA clone in CMV expression vector: NM_006297

Additional cDNA sequence:

AB208781.1 AK293542.1 AK300163.1 AK315332.1 BC023593.2 CR456728.1 CR591751.1 CR600609.1

CR610347.1 CR614880.1 CR617745.1

12 DOTS entries:

DT.452311 DT.100782706 DT.91761768 DT.100773970 DT.100027795 DT.100782718 DT.100782719 DT.87016286

DT.100637811 DT.95107355 DT.87016288 DT.91724728

24/374 AceView cDNA sequences (see all 374 ):

BM711287 AL134428 AA722476 BQ882089 AK124786 BU178401 BX091022 BM451621

BM698936 AL520680 AL526899 BX452522 CA395701 AA426207 F06425 AI983314

F08201 F05480 AW613956 F13079 AI424752 CR591751 AI206971 BE044126

highest scoring ESTs for XRCC1:

AL554050 AL556053 AL560022 AL560785 AW402221 AW410924 BC023593 BE249944 BE264560 BE270004

Unigene Cluster for XRCC1:

X-ray repair complementing defective repair in Chinese hamster cells 1

Hs.98493 [show with all ESTs]

Unigene Representative Sequence: NM_006297

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for XRCC1 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:											-								-
SP2:											-								-
SP3:
SP4:											-								-
SP5:																			-						-		-		-

About this scheme

ECgene alternative splicing isoforms for XRCC1

1 Ensembl transcript including schematic representation:

ENST00000262887

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XRCC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XRCC1

¹ / ² / ³

3 probe-sets matching XRCC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
160033_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	NM_006297	0.80	1.00	0.91	1
203655_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006297	0.80	1.00	0.91	1
203655_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks XRCC1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAGGGCCAG

SOURCE GeneReport for Unigene cluster: Hs.98493

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XRCC1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XRCC1¹	--	X-ray repair complementing defective repair in Chinese more	87.65(n) 89.51(a)	476447 XM_533653.2 XP_533653.2
chimpanzee (Pan troglodytes)	XRCC1¹	--	X-ray repair complementing defective repair in Chinese more	99.66(n) 99.66(a)	456094 XM_512717.2 XP_512717.2
cow (Bos taurus)	XRCC1¹	--	X-ray repair complementing defective repair in Chinese more	87.02(n) 87.94(a)	616905 XM_869042.2 XP_874135.2
rat (Rattus norvegicus)	Xrcc1¹	--	X-ray repair complementing defective repair in Chinese more	85.06(n) 86.65(a)	84495 NM_053435.1 NP_445887.1
mouse (Mus musculus)	Xrcc1^{1, 5}	7 (5.50 cM)⁵	X-ray repair complementing defective repair in Chinese more^{1, 5}	84.47(n)¹ 85.85(a)¹	22594¹ NM_009532.3¹ NP_033558.2¹ AI451314⁵ AK046611⁵ (see all 17)

About this table Species with no ortholog for XRCC1

ENSEMBL Gene Tree for XRCC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XRCC1 gene

ENSG00000196763²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: XRCC1_HUMAN, P18887

Polymorphism: Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and

age-related DNA damage

10/369 NCBI SNPs in XRCC1 are shown (see all 369 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 145)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs25491^1,2	C,F,H	48748166(-)	`GACGAC/TCCCGA`	1	P/S	mis¹ ese³		13	NA NS MN EU EA WA CSAM	2052
	rs25474^1,2	C,F,H	48741890(-)	`AGACCC/TGTATG`	1	P/L	mis¹ ese³		7	MN EU EA WA	756
	rs25490^1,2	C,F,H	48748181(-)	`AAGGCA/GCCGAG`	1	T/A	mis¹		13	NS MN CSAM EA EU WA NA	1306
	rs25496^1,2	C,F,H	48756942(-)	`GCTGGT/CGGGCA`	1	A/V	mis¹		18	NA NS MN CSAM EA EU WA	2554
	rs2307191^1,2	C,F,H	48749608(-)	`GGCCCC/TGTCCC`	1	P/L	mis¹ ese³		5	NA NS EA WA	1282
	rs25489^1,2	C,F,H	48748252(-)	`AACTCG/ATACCC`	1	H/R	mis¹ ese³		13	MN NA NS CSAM EA EU WA	2016
	rs25487^1,2	C,F,H	48747566(-)	`CTCCCG/AGAGGT`	1	R/Q	mis¹		13	NA NS MN CSAM EA WA	2102
--	rs25495^1,2	C,F	48757006(-)	`TGGARA/TAGGAG`	1	K/X	non¹ trp³		7	MN CSAM EA	602
	rs2682558^1,2	C,F	48739156(-)	`ACTGGG/AAATCT`	1	--	ng5¹		1	NS	172
	rs1799782^1,2	C,F	48749414(-)	`TCAGCC/TGGATC`	1	R/W	mis¹ ese³		20	MN NA NS CSAM EA EU WA	2784

About this table

HapMap Linkage Disequilibrium images for XRCC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 194360

10/43 Novoseek disease relationships for XRCC1 gene (see all 43 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
xeroderma pigmentosum	70.72	21	11016934 (1), 17593927 (1), 19109787 (1), 19443413 (1) (see all 20)
cancer	59.02	70	16172217 (6), 15896924 (4), 16550161 (4), 16137195 (3) (see all 40)
cancer lung	58.51	64	18999926 (4), 17417947 (4), 12618330 (3), 17705814 (3) (see all 31)
nsclc	48.79	18	15534883 (2), 19362955 (2), 16157195 (2), 16875604 (2) (see all 8)
bladder cancer	46.57	26	18272472 (5), 18336890 (3), 12223443 (2), 16284380 (2) (see all 14)
genetic susceptibility	45.31	4	15666192 (1), 15252855 (1), 17385092 (1), 14639127 (1)
carcinoma squamous cell	43.47	16	17614107 (2), 19230024 (2), 1574572 (1), 11782372 (1) (see all 13)
breast cancer	39.70	86	16457697 (6), 15666192 (5), 18481169 (5), 15734955 (4) (see all 31)
chromosomal aberrations	39.21	8	16904935 (2), 16997330 (2), 17603793 (1), 16596238 (1) (see all 7)
colorectal cancer	38.39	25	18806752 (4), 15800946 (3), 17009149 (3), 15679883 (2) (see all 11)

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2 PharmGKB disease relationships for XRCC1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	PD	12042672
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Human Gene Mutation Database: XRCC1
Genetic Association Database: XRCC1
Human Genome Epidemiology Navigator: XRCC1 (407 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/582 PubMed articles for XRCC1 gene (see all 582 ):

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. (PubMed id 2247054)^{2, 3, 4} Thompson L.H.... Carrano A.V. (1990)
Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (Codon 280). (PubMed id 16172217)^{1, 3, 6} Majumder M....Roy B. (2005)
A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. (PubMed id 12183419)^{1, 3, 6} Duell E.J....Kelsey K.T. (2002)
XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage. (PubMed id 16397295)^{1, 3, 4} Levy N....Menissier-de Murcia J. (2006)
[Association of genetic polymorphism of XRCC1 with susceptibility to acute childhood leukemia] (PubMed id 16111035)^{1, 3, 6} Zhu R....Xia Z. (2005)
The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms. (PubMed id 15534883)^{1, 3, 6} Liu G....Christiani D.C. (2004)
Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients. (PubMed id 15665590)^{1, 3, 6} Deligezer U. and Dalay N. (2004)
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. (PubMed id 14679022)^{1, 3, 6} Han J....Hunter D.J. (2003)
The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. (PubMed id 11782372)^{1, 3, 4} Nelson H.H.... Karagas M.R. (2002)
Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population. (PubMed id 16284386)^{1, 3, 6} Zhang Z....Xia Z. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7515	HGNC: 12828	AceView: XRCC1	Ensembl:ENSG00000073050	euGenes: HUgn7515
ECgene: XRCC1	H-InvDB: XRCC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for XRCC1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/xrcc1/

Licensable Technologies for XRCC1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XRCC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XRCC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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Antibodies & Assays for XRCC1

	Recombinant Proteins (XRCC1)
	Antibodies (XRCC1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for XRCC1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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XRCC1 Gene at Home site.
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XRCC1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for XRCC1

Summaries
for XRCC1

Genomic Location
for XRCC1

Proteins
for XRCC1

Protein Domains/
Families
for XRCC1

Gene Function
for XRCC1

Pathways & Interactions
for XRCC1

Drugs & Compounds
for XRCC1

Transcripts
for XRCC1

Expression
for XRCC1

Orthologs
for XRCC1

Paralogs
for XRCC1

SNPs/Variants
for XRCC1

Disorders & Mutations
for XRCC1

Medical News
for XRCC1

Publications
for XRCC1

Search for XRCC1

Genome Databases showing XRCC1

Other Databases showing XRCC1

Specialized Databases showing XRCC1

Licensable Technologies
for XRCC1

Services
for XRCC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XRCC1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor XRCC1

Summariesfor XRCC1

Genomic Locationfor XRCC1

Proteinsfor XRCC1

Protein Domains/Familiesfor XRCC1

Gene Functionfor XRCC1

Pathways & Interactionsfor XRCC1

Drugs & Compoundsfor XRCC1

Transcriptsfor XRCC1

Expression for XRCC1

Orthologsfor XRCC1

Paralogsfor XRCC1

SNPs/Variantsfor XRCC1

Disorders & Mutationsfor XRCC1

Medical Newsfor XRCC1

Publicationsfor XRCC1

Search for XRCC1

Genome Databases showing XRCC1

Other Databases showing XRCC1

Specialized Databases showing XRCC1

Licensable Technologiesfor XRCC1

Servicesfor XRCC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XRCC1

Summaries
for XRCC1

Genomic Location
for XRCC1

Proteins
for XRCC1

Protein Domains/
Families
for XRCC1

Gene Function
for XRCC1

Pathways & Interactions
for XRCC1

Drugs & Compounds
for XRCC1

Transcripts
for XRCC1

Expression
for XRCC1

Orthologs
for XRCC1

Paralogs
for XRCC1

SNPs/Variants
for XRCC1

Disorders & Mutations
for XRCC1

Medical News
for XRCC1

Publications
for XRCC1

Licensable Technologies
for XRCC1

Services
for XRCC1