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Aliases for XPR1 Gene

Aliases for XPR1 Gene

  • Xenotropic And Polytropic Retrovirus Receptor 1 2 3
  • SYG1 3 4 6
  • Xenotropic And Polytropic Murine Leukemia Virus Receptor X3 3 4
  • Protein SYG1 Homolog 3 4
  • X-Receptor 3 4
  • Xenotropic And Polytropic Retrovirus Receptor 2
  • X3 3
  • XR 4

External Ids for XPR1 Gene

Previous GeneCards Identifiers for XPR1 Gene

  • GC01P178125
  • GC01P176029
  • GC01P177121
  • GC01P177840
  • GC01P177332
  • GC01P178867
  • GC01P151831

Summaries for XPR1 Gene

GeneCards Summary for XPR1 Gene

XPR1 (Xenotropic And Polytropic Retrovirus Receptor 1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for XPR1 Gene

  • May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPR1 Gene

Genomics for XPR1 Gene

Regulatory Elements for XPR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for XPR1 Gene

Start:
180,632,004 bp from pter
End:
180,890,279 bp from pter
Size:
258,276 bases
Orientation:
Plus strand

Genomic View for XPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPR1 Gene

Proteins for XPR1 Gene

  • Protein details for XPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBH6-XPR1_HUMAN
    Recommended name:
    Xenotropic and polytropic retrovirus receptor 1
    Protein Accession:
    Q9UBH6
    Secondary Accessions:
    • O95719
    • Q7L8K9
    • Q8IW20
    • Q9NT19
    • Q9UFB9

    Protein attributes for XPR1 Gene

    Size:
    696 amino acids
    Molecular mass:
    81535 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for XPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XPR1 Gene

Proteomics data for XPR1 Gene at MOPED

Post-translational modifications for XPR1 Gene

  • Ubiquitination at Lys76 and Lys662
  • Modification sites at PhosphoSitePlus

Other Protein References for XPR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XPR1 Gene

Domains for XPR1 Gene

Protein Domains for XPR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for XPR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBH6

UniProtKB/Swiss-Prot:

XPR1_HUMAN :
  • Q9UBH6
Domain:
  • Contains 1 EXS domain.
  • Contains 1 SPX domain.
Family:
  • Belongs to the SYG1 (TC 2.A.94) family.
genes like me logo Genes that share domains with XPR1: view

No data available for Gene Families for XPR1 Gene

Function for XPR1 Gene

Molecular function for XPR1 Gene

GENATLAS Biochemistry: xenotropic and polytropic retrovirus receptor 1,widely expressed,potentially involved in G protein-coupled signal transduction
UniProtKB/Swiss-Prot Function: May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses.

Gene Ontology (GO) - Molecular Function for XPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity TAS 9988277
GO:0004888 transmembrane signaling receptor activity TAS 9927670
GO:0004930 G-protein coupled receptor activity TAS 9990033
genes like me logo Genes that share ontologies with XPR1: view

Phenotypes for XPR1 Gene

MGI mutant phenotypes for XPR1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with XPR1: view

Animal Model Products

CRISPR Products

miRNA for XPR1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XPR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for XPR1 Gene

Localization for XPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPR1 Gene COMPARTMENTS Subcellular localization image for XPR1 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for XPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane TAS 9927670
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with XPR1: view

Pathways for XPR1 Gene

SuperPathways for XPR1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for XPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 9990033
GO:0009615 response to virus IEA --
GO:0046718 viral entry into host cell IEA --
genes like me logo Genes that share ontologies with XPR1: view

No data available for Pathways by source for XPR1 Gene

Transcripts for XPR1 Gene

Unigene Clusters for XPR1 Gene

Xenotropic and polytropic retrovirus receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XPR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for XPR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -

Relevant External Links for XPR1 Gene

GeneLoc Exon Structure for
XPR1
ECgene alternative splicing isoforms for
XPR1

Expression for XPR1 Gene

mRNA expression in normal human tissues for XPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XPR1 Gene

This gene is overexpressed in Heart - Left Ventricle (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPR1 Gene

SOURCE GeneReport for Unigene cluster for XPR1 Gene Hs.227656

mRNA Expression by UniProt/SwissProt for XPR1 Gene

Q9UBH6-XPR1_HUMAN
Tissue specificity: Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle.
genes like me logo Genes that share expressions with XPR1: view

In Situ Assay Products

Orthologs for XPR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPR1 35
  • 99.71 (n)
  • 100 (a)
XPR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XPR1 35
  • 95.31 (n)
  • 96.26 (a)
XPR1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPR1 35
  • 95.26 (n)
  • 98.13 (a)
XPR1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpr1 35
  • 92.47 (n)
  • 95.4 (a)
Xpr1 16
Xpr1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPR1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XPR1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xpr1 35
  • 92.62 (n)
  • 95.98 (a)
chicken
(Gallus gallus)
Aves XPR1 35
  • 78.61 (n)
  • 83.88 (a)
XPR1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPR1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpr1 35
  • 74.76 (n)
  • 85.84 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-6n6.7 35
  • 72.75 (n)
  • 80.29 (a)
xpr1 36
  • 80 (a)
OneToMany
XPR1 (1 of 2) 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005557 35
  • 58.88 (n)
  • 57.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10481 36
  • 38 (a)
OneToMany
CG10483 35
  • 57.98 (n)
  • 56.63 (a)
CG10483 36
  • 54 (a)
OneToMany
CG2901 36
  • 40 (a)
OneToMany
CG7536 36
  • 56 (a)
OneToMany
CG7536 37
  • 56 (a)
CG10481 37
  • 33 (a)
CG2901 37
  • 40 (a)
CG10483 37
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39A1A.22 36
  • 46 (a)
OneToOne
Y39A1A.22 37
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL080W 35
  • 43.44 (n)
  • 31.99 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SYG1 35
  • 42.69 (n)
  • 32.06 (a)
SYG1 36
  • 22 (a)
OneToOne
SYG1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F27467g 35
  • 41.62 (n)
  • 31.26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHO1;H1 35
  • 45.6 (n)
  • 34.72 (a)
rice
(Oryza sativa)
Liliopsida Os06g0493600 35
  • 45.97 (n)
  • 33.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04201 35
  • 43.2 (n)
  • 33.47 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1827.07c 35
  • 44.56 (n)
  • 30.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for XPR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPR1 Gene

ENSEMBL:
Gene Tree for XPR1 (if available)
TreeFam:
Gene Tree for XPR1 (if available)

Paralogs for XPR1 Gene

No data available for Paralogs for XPR1 Gene

Variants for XPR1 Gene

Sequence variations from dbSNP and Humsavar for XPR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs769932 -- 180,867,089(-) tcagt(A/G)aacta intron-variant
rs769933 -- 180,867,071(-) aacaa(A/G)aaacc intron-variant
rs769934 -- 180,866,997(-) gggaa(C/T)atcac intron-variant
rs769935 -- 180,866,938(-) ggaga(C/T)atacc intron-variant
rs769936 -- 180,866,924(-) tgcta(A/G)atgac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPR1 Gene

Variant ID Type Subtype PubMed ID
nsv872578 CNV Gain 21882294
esv1216422 CNV Insertion 17803354
esv988017 CNV Deletion 20482838
esv2673886 CNV Deletion 23128226
esv267829 CNV Insertion 20981092
nsv3777 CNV Loss 18451855
esv2676627 CNV Deletion 23128226
nsv498695 CNV Loss 21111241
esv22705 CNV Loss 19812545
esv1112679 CNV Insertion 17803354
nsv159447 CNV Insertion 16902084
esv2452119 CNV Insertion 19546169
esv270103 CNV Insertion 20981092
esv273579 CNV Insertion 20981092

Relevant External Links for XPR1 Gene

HapMap Linkage Disequilibrium report
XPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPR1 Gene

Disorders for XPR1 Gene

(1) University of Copenhagen DISEASES for XPR1 Gene

Relevant External Links for XPR1

Genetic Association Database (GAD)
XPR1
Human Genome Epidemiology (HuGE) Navigator
XPR1
genes like me logo Genes that share disorders with XPR1: view

No data available for UniProtKB/Swiss-Prot for XPR1 Gene

Publications for XPR1 Gene

  1. A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction. (PMID: 9990033) Battini J.-L. … Miller A.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses. (PMID: 9927670) Tailor C.S. … Kabat D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  3. Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1. (PMID: 9988277) Yang Y.-L. … Cunningham J.M. (Nat. Genet. 1999) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells. (PMID: 20410264) Bhosle S. … Ly H. (J. Virol. 2010) 3

Products for XPR1 Gene

Sources for XPR1 Gene

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