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XPR1 Gene

protein-coding   GIFtS: 59

GC01P178867
xenotropic and polytropic retrovirus receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FLJ90308 2
OTTHUMP00000033084 2
SYG1 1, 2, 3, 5
X-receptor 3
X3 1, 2
XR 3
Descriptions
Protein SYG1 homolog 3
Xenotropic and polytropic murine leukemia virus receptor X3 3
xenotropic and polytropic retrovirus receptor 2
External Ids
HGNC: 128271
Entrez Gene: 92132
UniProtKB: Q9UBH63
Ensembl: ENSG000001433247
Search outside databases for aliases for XPR1 gene

Previous GC identifers: GC01P178125 GC01P176029 GC01P177121 GC01P177840 GC01P177332

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6
Function: May function in G-protein coupled signal transduction (By similarity). Potential receptor
for xenotropic and polytropic murine leukemia retroviruses

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XPR1 gene  

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.1

XPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P178867:     (about GC identifiers)

Start:
178,867,763 bp from pter
End:
179,122,106 bp from pter
Size:
254,344 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6 (See protein sequence)
Recommended Name: Xenotropic and polytropic retrovirus receptor 1  
Size: 696 amino acids; 81535 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Probable)
Developmental stage: Expressed in fetal liver
Caution: It is unclear whether its ability to act as a receptor for xenotropic and polytropic
murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human
Secondary accessions: O95719 Q7L8K9 Q8IW20 Q9NT19 Q9UFB9
Alternative splicing: 2 isoforms:  Q9UBH6-1   Q9UBH6-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001129141.1  NP_004727.2  


    ENSEMBL proteins: 
    ENSP00000356562 ENSP00000356561 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (XPR1)
    Human Recombinant Proteins from Abnova (XPR1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane TAS9927670
    GO:0005887 integral to plasma membrane TAS9927670
    About this table

    Antibodies for XPR1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for XPR1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (XPR1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (XPR1)
    Novus Biologicals Antibodies for XPR1

    Assays for XPR1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR004342 EXS_C
     IPR004331 SPX_N


       GeneDecks  XPR1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UBH6

    ProtoNet protein and cluster: Q9UBH6

    2 Blocks protein families:
    IPB004331 SPX
    IPB004342 EXS


    UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6
    Similarity: Belongs to the SYG1 family
    Similarity: Contains 1 EXS domain
    Similarity: Contains 1 SPX domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XPR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XPR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135669

                  Applied Biosystems Silencer® siRNAs for XPR1

                  Sigma-Aldrich siRNA and siRNA Panels for XPR1  
                         Sigma-Aldrich shRNA Panels and shRNA for XPR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135669
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135669
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001135669 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004736

    UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6
    Function: May function in G-protein coupled signal transduction (By similarity). Potential receptor
    for xenotropic and polytropic murine leukemia retroviruses

    Genatlas biochemistry entry for XPR1:
    xenotropic and polytropic retrovirus receptor 1,widely expressed,potentially involved in G
    protein-coupled signal transduction

    1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Xpr1):

    immune system

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930 G-protein coupled receptor activity TAS9990033
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for XPR1 (ENSP000003565623) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1AENSP000002633393STRING (score=.84)
    SLC20A2ENSP000003404653STRING (score=.721)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186 G-protein coupled receptor protein signaling pathway TAS9990033
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XPR1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XPR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XPR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135669

                  Sigma-Aldrich siRNA and siRNA Panels for XPR1  
                         Sigma-Aldrich shRNA Panels and shRNA for XPR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001135669  NM_004736  

    REFSEQ mRNAs for XPR1 gene (2 alternative transcripts): 

    NM_001135669.1   NM_004736.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001135669  NM_004736  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135669
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135669
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001135669 

    Additional cDNA sequence: 

    AB075495.1 AF089744.1 AF099082.1 AF115389.1 AK023131.1 AK056306.1 AK074789.1 AK309750.1 
    AL133058.1 AL137583.1 BC028576.1 BC041142.1 U79279.1 

    13 DOTS entries:

    DT.40283564  DT.100816393  DT.213078  DT.100816395  DT.314452  DT.100744891  DT.92433410  DT.305549 
    DT.95205369  DT.95270292  DT.439593  DT.99997220  DT.97816560 

    24/195 AceView cDNA sequences (see all 195 ):

    AA442026 AA405472 AA639413 BM709710 BX646587 BI850375 F10680 BF917451 
    CK819856 AU130961 BF939946 CB993994 AL133058 BM801869 CD109773 BU197378 
    AA961168 CB988296 AI473890 AW241631 AI423890 AA620742 AA488957 AA922312 

    highest scoring ESTs for XPR1:

    AL039438 H10324 AA090652 AA224474 AA317531 AA318775 AA319029 AA337024 AA405472 AA453474 

    Unigene Cluster for XPR1:

    Xenotropic and polytropic retrovirus receptor
    Hs.227656  [show with all ESTs]
    Unigene Representative Sequence: NM_004736


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for XPR1

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                          
    SP2:                                                              -                           

    About this scheme

    ECgene alternative splicing isoforms for XPR1

    2 Ensembl transcripts including schematic representations:
    ENST00000367590  ENST00000367589  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XPR1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XPR1

    1 / 2 / 3

    7 probe-sets matching XPR1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    77994_at2, 3 U95-E 1 1.00 1.00 0.71 0.88 H10324 1.00 1.00 1.00 1
    49333_at2, 3 U95-B 1 1.00 1.00 0.84 1.23 AL039438 1.00 1.00 1.00 1
    52034_at2, 3 U95-B 1 1.00 1.00 0.37 0.91 T65395 0.40 1.00 0.76 1

    226615_at2, 3 U133-B 1 1.00 1.00 -- -- BE439489 0.40 1.00 0.76 1

    222581_at2, 3 U133-B 1 1.00 1.00 -- -- AF089744 0.80 0.88 0.84 1

    226615_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222581_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  XPR1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCCCTTGGCC

    SOURCE GeneReport for Unigene cluster: Hs.227656

    UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6
    Tissue specificity: Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone
    marrow, heart, kidney, pancreas and skeletal muscle

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for XPR1 gene from 5/17 species (see all 17 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    XPR11   -- xenotropic and polytropic retrovirus receptor 94.38(n)
    96.97(a)
    490301  XM_853861.1  XP_858954.1 
    chimpanzee
    (Pan troglodytes)
    XPR11   -- xenotropic and polytropic retrovirus receptor 99.66(n)
    100(a)
    469603  XM_524986.2  XP_524986.2 
    cow
    (Bos taurus)
    XPR11   -- xenotropic and polytropic retrovirus receptor 95.35(n)
    96.26(a)
    536550  XM_616684.3  XP_616684.3 
    rat
    (Rattus norvegicus)
    Xpr11   -- xenotropic and polytropic retrovirus receptor 1 92.67(n)
    95.98(a)
    289424  XM_223117.4  XP_223117.3 
    mouse
    (Mus musculus)
    Xpr11, 5 1 (81.60 cM)5
    xenotropic and polytropic retrovirus receptor 11, 5 92.52(n)1
    95.4(a)1
    197751  NM_011273.21  NP_035403.11 
     AA2150245  AA4147185  (see all 31)
    About this table        Species with no ortholog for XPR1

    ENSEMBL Gene Tree for XPR1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1405 NCBI SNPs in XPR1 are shown (see all 1405 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 413)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs46510731,2
    A,C,F,H178867222(+) GTGCGA/GTCGGT 1 -- ng516Minor allele frequency- G:0.49MN EA EU WA 1670
    rs66563781,2
    A,C,F,H178867143(+) TTCTAT/CGGGGT 1 -- ng514Minor allele frequency- C:0.14EU EA WA 412
    rs73551471,2
    A,C,F,H179125800(+) TCCTTT/CTTCCT 2 -- ut31 trp32Minor allele frequency- C:0.03EU WA 218
    rs10610161,2
    A,C,F,H179120438(+) ACACAC/TAGTTT 2 -- ut31 ese39Minor allele frequency- N:0.01MN EA NA EU WA 814
    rs37619031,2
    A,C,F,H179122126(-) TAAAGC/TTAATA 2 -- ut316Minor allele frequency- T:0.36EU EA NA 392
    rs10430691,2
    A,C,F,H179125991(-) GAGAAA/CTTGTA 2 -- ut31 ese38Minor allele frequency- C:0.39MN EU EA WA NA 744
    rs10610151,2
    A,C,F,H179120342(+) CAGTAC/TCTTCA 2 -- ut318Minor allele frequency- T:0.29MN NA EU EA WA 744
    rs173020401,2
    C,F,H179123321(+) CATTTG/CTAAGA 2 -- ut3111Minor allele frequency- C:0.02NA EU EA WA 980
    rs46525241,2
    C,F,H178867593(+) GTAGAA/GAGCAG 1 -- ng512Minor allele frequency- G:0.06EA 142
    rs38560611,2
    C,F,H179120690(+) CTCTCG/ATAACA 2 -- ut314Minor allele frequency- A:0.01EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for XPR1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605237

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10 PubMed articles for XPR1 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9213 HGNC: 12827 AceView: XPR1 Ensembl:ENSG00000143324 euGenes: HUgn9213
    ECgene: XPR1 H-InvDB: XPR1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for XPR1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XPR1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for XPR1 Antibodies for XPR1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for XPR1 Browse small molecules at Sigma-Aldrich
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