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Aliases & Descriptions for XPR1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ90308 2 OTTHUMP00000033084 2 SYG1 1 , 2 , 3 , 5 X-receptor 3 X3 1 , 2 XR 3
Descriptions Protein SYG1 homolog 3 Xenotropic and polytropic murine leukemia virus receptor X3 3 xenotropic and polytropic retrovirus receptor 2
Search outside databases for aliases for XPR1 genePrevious GC identifers: GC01P178125 GC01P176029 GC01P177121 GC01P177840 GC01P177332
Summaries for XPR1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6 Function : May function in G-protein coupled signal transduction (By similarity). Potential receptorfor xenotropic and polytropic murine leukemia retroviruses
Genomic Location for XPR1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the XPR1 gene Entrez Gene cytogenetic band: 1q25.1 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25.1 XPR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P178867:
(about GC identifiers )
Start:
178,867,763 bp from pter
End:
179,122,106 bp from pter
Size:
254,344 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for XPR1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6 (See
protein sequence )Recommended Name: Xenotropic and polytropic retrovirus receptor 1 Size : 696 amino acids; 81535 Da
Subcellular location : Cell membrane; Multi-pass membrane protein (Probable)
Developmental stage : Expressed in fetal liver
Caution : It is unclear whether its ability to act as a receptor for xenotropic and polytropicmurine leukemia retroviruses is relevant in vivo and whether such viruses can infect human
Secondary accessions : O95719 Q7L8K9 Q8IW20 Q9NT19 Q9UFB9Alternative splicing : 2 isoforms : Q9UBH6-1 Q9UBH6-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001129141.1 NP_004727.2 ENSEMBL proteins: ENSP00000356562 ENSP00000356561 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for XPR1: Assays for XPR1:
Protein
Domains/ Families for XPR1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UBH6 ProtoNet protein and cluster: Q9UBH6
2 Blocks protein families : IPB004331 SPX IPB004342 EXS UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6 Similarity : Belongs to the SYG1 familySimilarity : Contains 1 EXS domainSimilarity : Contains 1 SPX domain
Gene Function for XPR1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
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Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001135669 Applied Biosystems Silencer ® siRNAs for XPR1 Sigma-Aldrich siRNA and siRNA Panels for XPR1 Sigma-Aldrich shRNA Panels and shRNA for XPR1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001135669                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001135669                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001135669  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004736 UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6 Function : May function in G-protein coupled signal transduction (By similarity). Potential receptorfor xenotropic and polytropic murine leukemia retroviruses
Genatlas biochemistry entry for XPR1 :xenotropic and polytropic retrovirus receptor 1,widely expressed,potentially involved in Gprotein-coupled signal transduction
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Xpr1) :1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004930 G-protein coupled receptor activity
TAS 9990033
About this table
Pathways & Interactions for XPR1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Interacting proteins for XPR1 (ENSP00000356562 3 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007186 G-protein coupled receptor protein signaling pathway
TAS 9990033
About this table
Drugs & Compounds for XPR1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for XPR1
Transcripts for XPR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001135669 Sigma-Aldrich siRNA and siRNA Panels for XPR1 Sigma-Aldrich shRNA Panels and shRNA for XPR1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001135669 NM_004736
REFSEQ mRNAs for XPR1 gene (2 alternative transcripts): NM_001135669.1 NM_004736.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001135669 NM_004736
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001135669                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001135669                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001135669  
Additional cDNA sequence: AB075495.1 AF089744.1 AF099082.1 AF115389.1 AK023131.1 AK056306.1 AK074789.1 AK309750.1 AL133058.1 AL137583.1 BC028576.1 BC041142.1 U79279.1
13 DOTS entries : DT.40283564 DT.100816393 DT.213078 DT.100816395 DT.314452 DT.100744891 DT.92433410 DT.305549 DT.95205369 DT.95270292 DT.439593 DT.99997220 DT.97816560
24/195 AceView cDNA sequences (see all 195
):AA442026 AA405472 AA639413 BM709710 BX646587 BI850375 F10680 BF917451 CK819856 AU130961 BF939946 CB993994 AL133058 BM801869 CD109773 BU197378 AA961168 CB988296 AI473890 AW241631 AI423890 AA620742 AA488957 AA922312
highest scoring ESTs for XPR1 :AL039438 H10324 AA090652 AA224474 AA317531 AA318775 AA319029 AA337024 AA405472 AA453474
Unigene Cluster for XPR1: Xenotropic and polytropic retrovirus receptor Hs.227656 [show with all ESTs ] Unigene Representative Sequence: NM_004736 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for XPR1 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 SP1 :                               SP2 :                     -          
About this scheme ECgene alternative splicing isoforms for XPR1 2 Ensembl transcripts including schematic representations : ENST00000367590
ENST00000367589
Expression for XPR1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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XPR1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for XPR1 1 / 2 / 3
7 probe-sets matching XPR1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCCCTTGGCCSOURCE GeneReport for Unigene cluster: Hs.227656 UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6 Tissue specificity : Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bonemarrow, heart, kidney, pancreas and skeletal muscle
Orthologs for XPR1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for XPR1 gene from 5/17 species (see all 17
)
About this table Species with no ortholog for XPR1 ENSEMBL Gene Tree for XPR1 Paralogs for XPR1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for XPR1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for XPR1 (up to first 250kb)
Disorders & Mutations for XPR1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605237
Medical News for XPR1 (Possibly Related Articles in
Doctor's Guide )
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Publications for XPR1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10 PubMed articles for XPR1 gene : A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction. (PubMed id 9990033) 1, 2, 3, 4 Battini J.L.... Miller A.D. (1999) Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1. (PubMed id 9988277) 3, 4 Yang Y.L....Cunningham J.M. (1999) Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses. (PubMed id 9927670) 3, 4 Tailor C.S.... Kabat D. (1999) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005) 4 Bechtel S....Schupp I. (2007) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 4 Olsen J.V....Mann M. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 4 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Change of tropism of SL3-2 murine leukemia virus, using random mutational libraries. (PubMed id 15308729) 1 Bahrami S....Pedersen F.S. (2004)
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Genome Databases showing XPR1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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(According to HUGE )
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Specialized Databases showing XPR1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for XPR1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for XPR1:
Recombinant Proteins (XPR1 ) Antibodies (XPR1 )
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