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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XPR1 Gene

protein-coding   GIFtS: 58
GCID: GC01P180601

Xenotropic And Polytropic Retrovirus Receptor 1

(Previous name: xenotropic and polytropic retrovirus receptor)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Xenotropic And Polytropic Retrovirus Receptor 11 2     X-receptor2 3
SYG12 3 5     Xenotropic And Polytropic Retrovirus Receptor1
Protein SYG1 Homolog2 3     X32
Xenotropic And Polytropic Murine Leukemia Virus Receptor X32 3     XR3

External Ids:    HGNC: 128271   Entrez Gene: 92132   Ensembl: ENSG000001433247   OMIM: 6052375   UniProtKB: Q9UBH63   

Export aliases for XPR1 gene to outside databases

Previous GC identifers: GC01P178125 GC01P176029 GC01P177121 GC01P177840 GC01P177332 GC01P178867 GC01P151831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for XPR1 Gene: 
XPR1 (xenotropic and polytropic retrovirus receptor 1) is a protein-coding gene. Diseases associated with XPR1 include shipyard eye, and leukemia. GO annotations related to this gene include transmembrane signaling receptor activity and G-protein coupled receptor activity.

UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6
Function: May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic
and polytropic murine leukemia retroviruses




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XPR1 gene promoter:
         POU2F1   p53   AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for XPR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.1

XPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P180601:  view genomic region     (about GC identifiers)

Start:
180,601,140 bp from pter      End:
180,859,415 bp from pter
Size:
258,276 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6 (See protein sequence)
Recommended Name: Xenotropic and polytropic retrovirus receptor 1  
Size: 696 amino acids; 81535 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Probable)
Developmental stage: Expressed in fetal liver
Caution: It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia
retroviruses is relevant in vivo and whether such viruses can infect human
Secondary accessions: O95719 Q7L8K9 Q8IW20 Q9NT19 Q9UFB9
Alternative splicing: 2 isoforms:  Q9UBH6-1   Q9UBH6-2   

Explore the universe of human proteins at neXtProt for XPR1: NX_Q9UBH6

Explore proteomics data for XPR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBH6

  • XPR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    XPR1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129141.1  NP_004727.2  

    ENSEMBL proteins: 
     ENSP00000356562   ENSP00000356561  

    Human Recombinant Protein Products for XPR1: 
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    OriGene Protein Over-expression Lysate for XPR1
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    Novus Biologicals XPR1 Proteins
    Novus Biologicals XPR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XPR1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9927670
    GO:0005887integral to plasma membrane TAS9927670
    GO:0016021integral to membrane ----

    XPR1 for ontologies           About GeneDecksing



    XPR1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for XPR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR004342 EXS_C
     IPR004331 SPX_N

    Graphical View of Domain Structure for InterPro Entry Q9UBH6

    ProtoNet protein and cluster: Q9UBH6

    2 Blocks protein domains:
    IPB004331 SPX
    IPB004342 EXS


    UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6
    Similarity: Belongs to the SYG1 (TC 2.A.94) family
    Similarity: Contains 1 EXS domain
    Similarity: Contains 1 SPX domain


    XPR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPR1_HUMAN, Q9UBH6
    Function: May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic
    and polytropic murine leukemia retroviruses

         Genatlas biochemistry entry for XPR1:
    xenotropic and polytropic retrovirus receptor 1,widely expressed,potentially involved in G protein-coupled signal
    transduction

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0004872receptor activity TAS9988277
    GO:0004888transmembrane signaling receptor activity TAS9927670
    GO:0004930G-protein coupled receptor activity TAS9990033
         
    XPR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Xpr1):
     immune system 

    XPR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for XPR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XPR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XPR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XPR1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XPR1
    8/124 QIAGEN miScript miRNA Assays for microRNAs that regulate XPR1 (see all 124):
    hsa-miR-549 hsa-miR-582-3p hsa-miR-3152-3p hsa-miR-376b hsa-miR-300 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidXPR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for XPR1
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                         Customized lentivirus expression plasmids for stable overexpression of XPR1 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XPR1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/18 Interacting proteins for XPR1 (Q9UBH63 ENSP000003565624) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    GNB5O147753I2D: score=3 
    MCCP235083I2D: score=3 
    DNAJA1P316893I2D: score=2 
    EFTUD1Q7Z2Z23I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9990033
    GO:0009615response to virus ----

    XPR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XPR1

    Search CenterWatch for drugs/clinical trials and news about XPR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for XPR1 gene (2 alternative transcripts): 
    NM_001135669.1  NM_004736.3  

    Unigene Cluster for XPR1:

    Xenotropic and polytropic retrovirus receptor 1
    Hs.227656  [show with all ESTs]
    Unigene Representative Sequence: NM_004736
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367590(uc009wxm.2 uc001goi.3 uc009wxn.3) ENST00000367589
    ENST00000498177 ENST00000464817 ENST00000467345
    miRNA
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    8/124 QIAGEN miScript miRNA Assays for microRNAs that regulate XPR1 (see all 124):
    hsa-miR-549 hsa-miR-582-3p hsa-miR-3152-3p hsa-miR-376b hsa-miR-300 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidXPR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for XPR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XPR1
    Clone
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    OriGene clones in human, mouse for XPR1 (see all 11)
    OriGene ORF clones in mouse, rat for XPR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): XPR1 (NM_004736)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPR1
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                         Customized lentivirus expression plasmids for stable overexpression of XPR1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for XPR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XPR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPR1

    Additional mRNA sequence: 

    AB075495.1 AF089744.1 AF099082.1 AF115389.1 AK023131.1 AK056306.1 AK074789.1 AK309750.1 
    AL133058.1 AL137583.1 BC028576.1 BC041142.1 U79279.1 

    13 DOTS entries:

    DT.40283564  DT.100816393  DT.213078  DT.100816395  DT.314452  DT.100744891  DT.92433410  DT.305549 
    DT.95205369  DT.95270292  DT.439593  DT.99997220  DT.97816560 

    24/195 AceView cDNA sequences (see all 195):

    AI283825 AW134922 AW768938 AA922312 AA488957 AU130961 CN479586 BU679549 
    CD643740 AA639413 AW514454 BX119011 AL137583 AI631927 AI243681 AA620742 
    AA906977 AL133058 CB993994 AA961168 Z39247 BU607805 AA405472 BM709710 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for XPR1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                          
    SP2:                                                              -                           


    ECgene alternative splicing isoforms for XPR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XPR1 expression in normal human tissues (normalized intensities)      XPR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTTGGCC
    XPR1 Expression
    About this image


    XPR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             gastrocnemius muscle   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             brain/midbrain   
     
     Eye (Sensory Organs)
             Retina
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See XPR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XPR1

    SOURCE GeneReport for Unigene cluster: Hs.227656

    UniProtKB/Swiss-Prot: XPR1_HUMAN, Q9UBH6
    Tissue specificity: Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart,
    kidney, pancreas and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including XPR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPR1 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpr11 , 5 xenotropic and polytropic retrovirus receptor 11, 5 92.47(n)1
    95.4(a)1
      1 (66.49 cM)5
    197751  NM_011273.21  NP_035403.11 
     1552757015 
    chicken
    (Gallus gallus)
    Aves XPR11 xenotropic and polytropic retrovirus receptor 1 78.6(n)
    83.84(a)
      424415  XM_003641660.1  XP_003641708.1 
    lizard
    (Anolis carolinensis)
    Reptilia XPR16
    Uncharacterized protein
    89(a)
    1 ↔ 1
    4(69924882-69977291)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX742319.12   -- 79.05(n)    BX742319.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5623521 similar to Xpr1-prov protein 72.75(n)
    80.29(a)
      562352  XM_003199057.1  XP_003199105.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG75363
    CG104831
    CG104831 56(a)
    (best of 4)3
    57.98(n)1
    56.63(a)1
      16F63
    386661  NM_139743.31  NP_648000.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39A1A.223   -- 46(a)   III(10775457-10778188)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SYG1(YIL047C)4 Plasma membrane protein of unknown function; truncation more   --   9(267823-265115) 854764  NP_012217.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G694801 phosphate transporter PHO1-10 47.3(n)
    34.23(a)
      843280  NM_105615.3  NP_177107.2 


    ENSEMBL Gene Tree for XPR1 (if available)
    TreeFam Gene Tree for XPR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5070 SNPs in XPR1 are shown (see all 5070)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483616641,2
    --180599173(+) TGGGAA/TTACAG 2 -- us2k10--------
    rs1416813781,2
    --180599181(+) CAGGCA/GTGAGT 2 -- us2k10--------
    rs285565861,2
    C,F--180599401(+) AGTGTG/ACCATG 2 -- us2k14Minor allele frequency- A:0.06WA CSA NA 242
    rs1926101751,2
    --180599501(+) TTTCCC/TAGGCA 2 -- us2k10--------
    rs730476691,2
    C,F--180599560(+) ACACAT/CATTCC 2 -- us2k13Minor allele frequency- C:0.25WA 122
    rs1441625031,2
    C--180599664(+) CACTC-/TTCT  
            
    TTCTT
    2 -- us2k10--------
    rs1505435401,2
    --180599714(+) TAAGGC/TTTTTA 2 -- us2k10--------
    rs1845924251,2
    C--180599849(+) GTACAC/TGGAGA 2 -- us2k10--------
    rs38199531,2
    C,F--180600017(-) AGCTAA/C/G/
            
    AACAG
    2 -- us2k15NA CSA WA EA 362
    rs746271921,2
    C,F--180600035(+) TCAAGA/GCCAGC 2 -- us2k12Minor allele frequency- G:0.04NA 122

    HapMap Linkage Disequilibrium report for XPR1 (180601140 - 180851140 bp, first 250kb of XPR1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for XPR1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676627CNV Deletion23128226
    esv2673886CNV Deletion23128226
    esv988017CNV Deletion20482838
    esv273579CNV Insertion20981092
    esv267829CNV Insertion20981092
    esv1216422CNV Insertion17803354
    nsv159447CNV Insertion16902084
    esv270103CNV Insertion20981092
    esv1112679CNV Insertion17803354
    esv2452119CNV Insertion19546169

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605237    OMIM disorders: --

    5 diseases for XPR1:    About MalaCards
    shipyard eye    leukemia    chronic fatigue syndrome    protein s deficiency
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for XPR1:
    Chronic fatigue syndrome

    XPR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): XPR1
    Human Genome Epidemiology (HuGE) Navigator: XPR1 (2 documents)

    Export disorders for XPR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XPR1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with XPR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction. (PubMed id 9990033)1, 2, 3, 9 Battini J.-L.... Miller A.D. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1. (PubMed id 9988277)1, 2 Yang Y.-L....Cunningham J.M. (1999)
    4. Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses. (PubMed id 9927670)1, 2 Tailor C.S.... Kabat D. (1999)
    5. Xpr1 is an atypical G-protein-coupled receptor that m ediates xenotropic and polytropic murine retrovirus neurotoxicity. (PubMed id 22090134)1 Vaughan A.E....Miller A.D. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Evaluation of cellular determinants required for in v itro xenotropic murine leukemia virus-related virus entry into human prostate c ancer and noncancerous cells. (PubMed id 20410264)1 Bhosle S....Ly H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9213 HGNC: 12827 AceView: XPR1 Ensembl:ENSG00000143324 euGenes: HUgn9213
    ECgene: XPR1 H-InvDB: XPR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XPR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XPR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for XPR1 gene:
    Search GeneIP for patents involving XPR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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