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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XPOT Gene

protein-coding   GIFtS: 62
GCID: GC12P064798

Exportin, TRNA

(Previous names: exportin, tRNA (nuclear export receptor for tRNAs))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Exportin, TRNA1 2     exportin(tRNA)2
Exportin, TRNA (Nuclear Export Receptor For TRNAs)1 2     exportin-T2
TRNA Exportin2 3     Exportin(tRNA)3
XPO32     

External Ids:    HGNC: 128261   Entrez Gene: 112602   Ensembl: ENSG000001845757   OMIM: 6031805   UniProtKB: O435923   

Export aliases for XPOT gene to outside databases

Previous GC identifers: GC12U990131 GC07P055820 GC12P064514 GC12P063090 GC12P063084 GC12P061850


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XPOT Gene:
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the
nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and
GTP-bound RAN. (provided by RefSeq, Jul 2008)

GeneCards Summary for XPOT Gene: 
XPOT (exportin, tRNA) is a protein-coding gene. Diseases associated with XPOT include low tension glaucoma, and glaucoma. GO annotations related to this gene include protein transporter activity and tRNA binding.

UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592
Function: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran
in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated
through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of
the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of
the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of
transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the
GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Gene Wiki entry for XPOT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XPOT gene promoter:
         Sox5   Pbx1a   MyoD   Pax-2   CUTL1   Pax-2a   E47   N-Myc   ATF6   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPOT promoter sequence
   Search SABiosciences Chromatin IP Primers for XPOT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPOT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.2   Ensembl cytogenetic band:  12q14.2   HGNC cytogenetic band: 12q14.1

XPOT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPOT gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P064798:  view genomic region     (about GC identifiers)

Start:
64,798,130 bp from pter      End:
64,844,907 bp from pter
Size:
46,778 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592 (See protein sequence)
Recommended Name: Exportin-T  
Size: 962 amino acids; 109964 Da
Subunit: Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with
Ran and tRNA in a GTP-dependent manner
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the
cytoplasm. Shuttles between the nucleus and the cytoplasm
Secondary accessions: A6NLH1 O43784 Q8WUG2 Q9BVS7

Explore the universe of human proteins at neXtProt for XPOT: NX_O43592

Explore proteomics data for XPOT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43592

  • XPOT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    XPOT Protein Expression
    REFSEQ proteins: NP_009166.2  
    ENSEMBL proteins: 
     ENSP00000327821   ENSP00000441376   ENSP00000383722   ENSP00000444345  

    Human Recombinant Protein Products for XPOT: 
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    Novus Biologicals XPOT Proteins
    Novus Biologicals XPOT Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005643colocalizes with nuclear pore IDA9660920
    GO:0005654nucleoplasm IDA9660920
    GO:0005737cytoplasm IDA9660920

    XPOT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    XPO: Exportins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O43592

    ProtoNet protein and cluster: O43592

    1 Blocks protein domain: IPB013598 Exportin 1-like

    UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592
    Similarity: Belongs to the exportin family


    XPOT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPOT_HUMAN, O43592
    Function: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran
    in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated
    through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of
    the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of
    the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of
    transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the
    GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

         Genatlas biochemistry entry for XPOT:
    exportin (tRNA),RanGTP-binding,importin beta-related factor with predominantly nuclear localization,specific
    mediator of tRNA export,shuttling between nucleus and cytoplasm and interacting with nuclear pore complexes (NPC)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IDA9660920
    GO:0005488binding ----
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ----
         
    XPOT for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for XPOT:
     Increased Salmonella enterica   Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for XPOT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XPOT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XPOT 
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    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate XPOT:
    hsa-miR-3163 hsa-miR-1283 hsa-miR-891b hsa-miR-183 hsa-miR-340 hsa-miR-660
    SwitchGear 3'UTR luciferase reporter plasmidXPOT 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPOT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for XPOT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ran Pathway
    Ran Pathway
    2RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for XPOT
        Ran Pathway


    1         Kegg Pathway  (Kegg details for XPOT):
        RNA transport


    XPOT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XPOT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/73 Interacting proteins for XPOT (O435922, 3 ENSP000003278214) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48442 I2D: score=2 
    TNFRSF1AP194382, 3MINT-49330 I2D: score=2 
    TNFRSF1BP203332, 3MINT-49417 I2D: score=2 
    RANP628263, ENSP000003961274I2D: score=5 STRING: ENSP00000396127
    CAMKK2Q96RR43, ENSP000003127414I2D: score=3 STRING: ENSP00000312741
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006409tRNA export from nucleus IDA9660920
    GO:0006886intracellular protein transport IEA--

    XPOT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    XPOT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XPOT

    1 HMDB Compound for XPOT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for XPOT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna 76.6 24 10199570 (5), 17224653 (2), 9857198 (1), 10657246 (1) (see all 6)
    calcitriol 43.3 3 16707848 (2), 16847355 (1)

    Search CenterWatch for drugs/clinical trials and news about XPOT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for XPOT gene: 
    NM_007235.4  

    Unigene Cluster for XPOT:

    Exportin, tRNA
    Hs.85951  [show with all ESTs]
    Unigene Representative Sequence: NM_007235
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332707(uc009zqm.2 uc001ssb.3) ENST00000540203 ENST00000400935
    ENST00000542958 ENST00000538086 ENST00000541842
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate XPOT:
    hsa-miR-3163 hsa-miR-1283 hsa-miR-891b hsa-miR-183 hsa-miR-340 hsa-miR-660
    SwitchGear 3'UTR luciferase reporter plasmidXPOT 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: XPOT (NM_007235)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPOT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPOT
    Sirion Biotech Customized lentivirus for stable overexpression of XPOT 
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    OriGene qPCR primer pairs and template standards for XPOT
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPOT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPOT

    Additional mRNA sequence: 

    AF039022.1 AK292884.1 AK308108.1 BC000950.2 BC020569.1 Y16414.1 

    13 DOTS entries:

    DT.217287  DT.121043242  DT.121205831  DT.100823534  DT.120834106  DT.121205839  DT.91762614  DT.92035953 
    DT.95228395  DT.40197619  DT.91762627  DT.97762902  DT.97785147 

    24/372 AceView cDNA sequences (see all 372):

    AI360393 CA311522 CA432790 CR613510 AA233543 AA361631 BE079848 CK821335 
    AA598447 AI140173 BI494978 BC020569 AA361677 AW206505 N27568 CA420496 
    CF128915 BU154261 AI984005 AW500282 AI912188 BF593191 N28562 AW081614 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for XPOT (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
    SP1:                    -                                                                                                           -                           
    SP2:                                                                                                                                                            
    SP3:        -           -                                                                                                                                       
    SP4:        -           -                       -                                                                                                               
    SP5:                                                                                                              -                 -                           

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
    SP1:                                                            
    SP2:                                      -                     
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for XPOT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XPOT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGGTCCAAA
    XPOT Expression
    About this image


    See XPOT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XPOT

    SOURCE GeneReport for Unigene cluster: Hs.85951
        SABiosciences Custom PCR Arrays for XPOT
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPOT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPOT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPOT gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpot1 , 5 exportin, tRNA (nuclear export receptor for tRNAs)1, 5 87.01(n)1
    95.53(a)1
      10 (69.86 cM)5
    731921  NM_001081056.11  NP_001074525.11 
     1215873805 
    chicken
    (Gallus gallus)
    Aves XPOT1 exportin, tRNA (nuclear export receptor for tRNAs) 83.44(n)
    93.87(a)
      417824  NM_001199606.1  NP_001186535.1 
    lizard
    (Anolis carolinensis)
    Reptilia XPOT6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    5(50489074-50509237)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.59142 Transcribed sequence with strong similarity to protein more 80.19(n)    AL965523.2 
    zebrafish
    (Danio rerio)
    Actinopterygii xpot1 exportin, tRNA (nuclear export receptor for tRNAs) 70.24(n)
    78.44(a)
      558020  NM_001044852.1  NP_001038317.1 
    worm
    (Caenorhabditis elegans)
    Secernentea xpo-31 Protein XPO-3 43.24(n)
    28.23(a)
      177581  NM_068919.5  NP_501320.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LOS1(YKL205W)4
    LOS11
    Nuclear pore protein involved in nuclear export of more4
    Los1p1
    41.28(n)1
    22.97(a)1
      11(50051-53353)4
    8536301, 4  NP_012717.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PSD1 protein PAUSED 42.69(n)
    28.62(a)
      843588  NM_001084344.1  NP_001077813.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06133001 hypothetical protein 41.81(n)
    27.64(a)
      4343885  NM_001066790.1  NP_001060255.1 


    ENSEMBL Gene Tree for XPOT (if available)
    TreeFam Gene Tree for XPOT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for XPOT gene

    XPOT for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for XPOT
    PGOHUM00000234963 PGOHUM00000247516 PGOHUM00000233250


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/866 SNPs in XPOT are shown (see all 866)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903320311,2
    --64796200(+) CACTCA/GCCCTC 1 -- us2k10--------
    rs286447731,2
    C,F--64796294(+) CAGATT/CGGGCC 1 -- us2k19Minor allele frequency- C:0.42WA NA CSA EA 370
    rs744435321,2
    F--64796465(+) GCAAGG/TATTAC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1815836761,2
    --64796479(+) CAAAAC/GAAAAT 1 -- us2k10--------
    rs1853451521,2
    --64796515(+) TATTTC/TGTTGG 1 -- us2k10--------
    rs1181411501,2
    F--64796602(+) AAGCTG/AAGGTG 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1162242791,2
    C,F--64796712(+) GCACCC/TGTAGT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1902045361,2
    --64796814(+) TAACAA/GAGCGA 1 -- us2k10--------
    rs1825506301,2
    --64796871(+) TAGCGA/CCATCT 1 -- us2k10--------
    rs1880620561,2
    --64796976(+) TCTTGA/GACAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for XPOT (64798130 - 64844907 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for XPOT:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745988CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing XPOT
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603180    OMIM disorders: --

    3 diseases for XPOT:    About MalaCards
    low tension glaucoma    glaucoma    leukemia


    XPOT for disorders           About GeneDecksing

    Genetic Association Database (GAD): XPOT
    Human Genome Epidemiology (HuGE) Navigator: XPOT (2 documents)

    Export disorders for XPOT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XPOT gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with XPOT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a tRNA-specific nuclear export receptor. (PubMed id 9660920)1, 2, 3, 9 Kutay U.... Goerlich D. (1998)
    2. Identification of a nuclear export receptor for tRNA. (PubMed id 9512417)1, 2, 3 Arts G.-J.... Mattaj I.W. (1998)
    3. The role of exportin-t in selective nuclear export of mature tRNAs. (PubMed id 9857198)1, 2, 9 Arts G.-J.... Mattaj I.W. (1998)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. (PubMed id 12138183)1, 2 Kuersten S.... Mattaj I.W. (2002)
    7. Interaction of immobilized human exportin-t with calf liver tRNA. (PubMed id 17224653)1, 9 Li S. and Sprinzl M. (2006)
    8. 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. (PubMed id 16707848)1, 9 Suzuki T....Isemura M. (2006)
    9. Export and transport of tRNA are coupled to a multi-protein complex. (PubMed id 10657246)1, 9 Kruse C....Muller P.K. (2000)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11260 HGNC: 12826 AceView: XPOT Ensembl:ENSG00000184575 euGenes: HUgn11260
    ECgene: XPOT Kegg: 11260 H-InvDB: XPOT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XPOT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XPOT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for XPOT gene:
    Search GeneIP for patents involving XPOT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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