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Aliases &
Descriptions
for XPOT
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| Exportin(tRNA) 3 | | XPO3 1, 2 | | exportin-T 2 |
| | | Descriptions |
|---|
| exportin, tRNA (nuclear export receptor for tRNAs) 2 | | tRNA exportin 2, 3 |
|
| |
Search outside databases for aliases for XPOT genePrevious GC identifers: GC12U990131 GC07P055820 GC12P064514 GC12P063090 |
Summaries
for XPOT(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for XPOT:
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of
tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once
exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq]
UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592Function: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to
the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore
complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export
complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP
(induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor.
XPOT then return to the nuclear compartment and mediate another round of transport. The
directionality of nuclear export is thought to be conferred by an asymmetric distribution of the
GTP- and GDP-bound forms of Ran between the cytoplasm and nucleusGene Wiki entry for XPOT |
Genomic Location
for XPOT
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the XPOT gene 
Entrez Gene cytogenetic band: 12q14.2 Ensembl cytogenetic band: 12q14.2 HGNC cytogenetic band: 12q14.1XPOT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P063084:
(about GC identifiers)
Start:
|
63,084,500 bp from pter |
End:
|
63,128,731 bp from pter |
Size:
|
44,232 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins
for XPOT
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592 (See
protein sequence)Recommended Name: Exportin-T Size: 962 amino acids; 109964 Da
Subunit: Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins.
Interacts with Ran and tRNA in a GTP-dependent manner
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex
translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm
Secondary accessions: A6NLH1 O43784 Q8WUG2 Q9BVS7REFSEQ proteins: NP_009166.2
ENSEMBL proteins: ENSP00000327821
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for XPOT:
Assays for XPOT: | Protein
Domains/
Families
for XPOT(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43592
ProtoNet protein and cluster: O43592 1 Blocks protein family: IPB013598 Exportin 1-like
UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592Similarity: Belongs to the exportin family | Gene Function
for XPOT
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007235
 Applied Biosystems Silencer® siRNAs for XPOT
 Sigma-Aldrich siRNA for XPOT
Sigma-Aldrich shRNA for XPOT
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_007235
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007235
untagged cDNA clone in CMV expression vector: NM_007235
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_007235
UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592Function: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to
the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore
complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export
complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP
(induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor.
XPOT then return to the nuclear compartment and mediate another round of transport. The
directionality of nuclear export is thought to be conferred by an asymmetric distribution of the
GTP- and GDP-bound forms of Ran between the cytoplasm and nucleusGenatlas biochemistry entry for XPOT:exportin (tRNA),RanGTP-binding,importin beta-related factor with predominantly nuclear
localization,specific mediator of tRNA export,shuttling between nucleus and cytoplasm and
interacting with nuclear pore complexes (NPC)2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for XPOT
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/22 Interacting proteins for XPOT (ENSP000003278213 O435922) via UniProtKB, MINT, and/or STRING (see all 22
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
About this table
|
Drugs & Compounds
for XPOT(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for XPOT
1  Novoseek chemical compound relationship for XPOT gene
About this table
|
Transcripts
for XPOT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007235
Sigma-Aldrich siRNA for XPOT
Sigma-Aldrich shRNA for XPOT
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_007235 REFSEQ mRNAs for XPOT gene: NM_007235.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007235
OriGene GFP tagged cDNA clone in CMV expression vector: NM_007235
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007235
untagged cDNA clone in CMV expression vector: NM_007235
Additional cDNA sequence: AF039022.1 AK292884.1 AK308108.1 BC000950.2 BC020569.1 CR613510.1 CR617666.1 Y16414.1 13 DOTS entries: DT.217287 DT.121043242 DT.121205831 DT.100823534 DT.120834106 DT.121205839 DT.91762614 DT.92035953 DT.95228395 DT.40197619 DT.91762627 DT.97762902 DT.97785147 24/372 AceView cDNA sequences (see all 372
):BQ438030 AA598447 BI494977 CD642924 CB215702 AW081614 AL120700 BC020569 F11364 BU615338 AW500282 AI799368 AI862335 AW296752 AA741091 Y16414 BM564749 AA256044 CA311522 AA233543 BF593191 AA361631 BQ894570 BM053031
 highest scoring ESTs for XPOT:AF039022 AA010377 AA112285 AA167756 AA194650 AA233543 AA256044 AA402440 AA668988 AA700503 Unigene Cluster for XPOT: Exportin, tRNA (nuclear export receptor for tRNAs) Hs.85951 [show with all ESTs]Unigene Representative Sequence: NM_007235
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for XPOT (see all 9
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | |
| ExUns: | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for XPOT
1 Ensembl transcript including schematic representation: ENST00000332707
|
Expression
for XPOT
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| XPOT expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for XPOT
1 / 2 / 3 3 probe-sets matching XPOT gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCGGTCCAAA
SOURCE GeneReport for Unigene cluster: Hs.85951
Expression variation in blood from EXPOLDB for XPOT |
Orthologs
for XPOT
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XPOT gene from 5/18 species (see all 18
)
About this table Species with no ortholog for XPOT
ENSEMBL Gene Tree for XPOT | Paralogs
for XPOT(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Pseudogenes
- 1 related pseudogene
|
SNPs/Variants
for XPOT(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for XPOT (up to first 250kb)
|
Disorders & Mutations
for XPOT
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603180
|
Medical News
for XPOT(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for XPOT (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/21 PubMed articles for XPOT gene (see all 21
):- Identification of a tRNA-specific nuclear export receptor. (PubMed id 9660920)1, 2, 3, 4 Kutay U.... Goerlich D. (1998)
- Identification of a nuclear export receptor for tRNA. (PubMed id 9512417)2, 3, 4 Arts G.J....Mattaj I.W. (1998)
- The role of exportin-t in selective nuclear export of mature tRNAs. (PubMed id 9857198)1, 3, 4 Arts G.-J.... Mattaj I.W. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. (PubMed id 12138183)3, 4 Kuersten S.... Mattaj I.W. (2002)
- Interaction of immobilized human exportin-t with calf liver tRNA. (PubMed id 17224653)1, 3 Li S. and Sprinzl M. (2006)
- 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. (PubMed id 16707848)1, 3 Suzuki T....Isemura M. (2006)
- Export and transport of tRNA are coupled to a multi-protein complex. (PubMed id 10657246)1, 3 Kruse C....Muller P.K. (2000)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)4 Scherer S.E.... Gibbs R.A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for XPOT
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing XPOT
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing XPOT
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XPOT(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for XPOT(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for XPOT:
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| | |  | Search Tocris compounds for XPOT |
|
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