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Aliases for XPOT Gene

Aliases for XPOT Gene

  • Exportin For TRNA 2 3 5
  • Exportin, TRNA (Nuclear Export Receptor For TRNAs) 2 3
  • Exportin(TRNA) 3 4
  • TRNA Exportin 3 4
  • Exportin, TRNA 2
  • Exportin-T 3
  • XPO3 3

External Ids for XPOT Gene

Previous GeneCards Identifiers for XPOT Gene

  • GC12U990131
  • GC07P055820
  • GC12P064514
  • GC12P063090
  • GC12P063084
  • GC12P064798
  • GC12P061850

Summaries for XPOT Gene

Entrez Gene Summary for XPOT Gene

  • This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

GeneCards Summary for XPOT Gene

XPOT (Exportin For TRNA) is a Protein Coding gene. Diseases associated with XPOT include 12Q14 Microdeletion Syndrome and Glaucoma, Normal Tension. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot for XPOT Gene

  • Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for XPOT Gene

Additional gene information for XPOT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPOT Gene

Genomics for XPOT Gene

Regulatory Elements for XPOT Gene

Enhancers for XPOT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H064450 1.1 ENCODE 11.1 +48.0 48018 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS SP3 LEMD3 XPOT RPS11P6 TBK1 ENSG00000277895
GH12H064458 0.9 Ensembl ENCODE 10.2 +55.1 55102 1 IRF2 SIN3A CHD1 ELF1 ZNF592 NBN ZNF600 CHD2 XPOT RPS11P6 RASSF3 LOC105369804 TBK1 ENSG00000277895
GH12H064252 0.8 Ensembl ENCODE 10.3 -151.4 -151440 1 ZSCAN4 ZNF133 CEBPB CEBPG RPS11P6 RNU6-1009P XPOT ENSG00000255629 C12orf56 ENSG00000256192 C12orf66
GH12H064461 0.8 FANTOM5 ENCODE 10.2 +57.6 57553 1 ZNF792 FOS WT1 SP7 TBK1 XPOT RPS11P6 RASSF3 LOC105369804 C12orf66 ENSG00000277895
GH12H064455 1.1 Ensembl ENCODE 5.2 +52.6 52558 2 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT ZSCAN4 ZBTB40 TCF12 GATA2 ATF7 TBK1 XPOT ENSG00000277895 RASSF3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XPOT on UCSC Golden Path with GeneCards custom track

Promoters for XPOT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000053170 450 2001 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766

Genomic Location for XPOT Gene

Chromosome:
12
Start:
64,404,350 bp from pter
End:
64,451,127 bp from pter
Size:
46,778 bases
Orientation:
Plus strand

Genomic View for XPOT Gene

Genes around XPOT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPOT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPOT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPOT Gene

Proteins for XPOT Gene

  • Protein details for XPOT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43592-XPOT_HUMAN
    Recommended name:
    Exportin-T
    Protein Accession:
    O43592
    Secondary Accessions:
    • A6NLH1
    • O43784
    • Q8WUG2
    • Q9BVS7

    Protein attributes for XPOT Gene

    Size:
    962 amino acids
    Molecular mass:
    109964 Da
    Quaternary structure:
    • Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner.

neXtProt entry for XPOT Gene

Post-translational modifications for XPOT Gene

  • Ubiquitination at Lys557
  • Modification sites at PhosphoSitePlus

Other Protein References for XPOT Gene

No data available for DME Specific Peptides for XPOT Gene

Domains & Families for XPOT Gene

Gene Families for XPOT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for XPOT Gene

Suggested Antigen Peptide Sequences for XPOT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43592

UniProtKB/Swiss-Prot:

XPOT_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPOT: view

Function for XPOT Gene

Molecular function for XPOT Gene

GENATLAS Biochemistry:
exportin (tRNA),RanGTP-binding,importin beta-related factor with predominantly nuclear localization,specific mediator of tRNA export,shuttling between nucleus and cytoplasm and interacting with nuclear pore complexes (NPC)
UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 9660920
GO:0003723 RNA binding IEA --
GO:0008536 Ran GTPase binding IBA,IEA --
genes like me logo Genes that share ontologies with XPOT: view
genes like me logo Genes that share phenotypes with XPOT: view

Animal Models for XPOT Gene

MGI Knock Outs for XPOT:
  • Xpot tm3b(EUCOMM)Hmgu

Animal Model Products

CRISPR Products

miRNA for XPOT Gene

miRTarBase miRNAs that target XPOT

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for XPOT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XPOT Gene

Localization for XPOT Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPOT Gene

Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPOT gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 colocalizes_with nuclear pore IDA 9660920
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA,IDA 9660920
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with XPOT: view

Pathways & Interactions for XPOT Gene

genes like me logo Genes that share pathways with XPOT: view

Pathways by source for XPOT Gene

1 KEGG pathway for XPOT Gene
1 Qiagen pathway for XPOT Gene

Gene Ontology (GO) - Biological Process for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006409 tRNA export from nucleus TAS,IDA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0071528 tRNA re-export from nucleus IBA --
genes like me logo Genes that share ontologies with XPOT: view

No data available for SIGNOR curated interactions for XPOT Gene

Drugs & Compounds for XPOT Gene

(2) Drugs for XPOT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for XPOT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XPOT: view

Transcripts for XPOT Gene

Unigene Clusters for XPOT Gene

Exportin, tRNA:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for XPOT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for XPOT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: - -
SP2:
SP3: - -
SP4: - - -
SP5: - -
SP6: -
SP7:
SP8:
SP9: -

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for XPOT Gene

GeneLoc Exon Structure for
XPOT
ECgene alternative splicing isoforms for
XPOT

Expression for XPOT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XPOT Gene

Protein differential expression in normal tissues from HIPED for XPOT Gene

This gene is overexpressed in Bone (57.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XPOT Gene



Protein tissue co-expression partners for XPOT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XPOT Gene:

XPOT

SOURCE GeneReport for Unigene cluster for XPOT Gene:

Hs.85951

Evidence on tissue expression from TISSUES for XPOT Gene

  • Nervous system(3)
  • Eye(2)
genes like me logo Genes that share expression patterns with XPOT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPOT Gene

Orthologs for XPOT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPOT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPOT 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia XPOT 33 34
  • 95.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia XPOT 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XPOT 33 34
  • 94.28 (n)
oppossum
(Monodelphis domestica)
Mammalia XPOT 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpot 33 16 34
  • 87.01 (n)
chicken
(Gallus gallus)
Aves XPOT 33 34
  • 83.44 (n)
lizard
(Anolis carolinensis)
Reptilia XPOT 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpot 33
  • 78.76 (n)
Str.5914 33
zebrafish
(Danio rerio)
Actinopterygii xpot 33 34
  • 70.24 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13873 33
worm
(Caenorhabditis elegans)
Secernentea xpo-3 33 34
  • 43.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14036g 33
  • 43.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LOS1 33 34 36
  • 41.82 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR424C 33
  • 40.36 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PSD 33
  • 43.15 (n)
rice
(Oryza sativa)
Liliopsida Os07g0613300 33
  • 42.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes los1 33
  • 44.19 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11169 33
  • 41.52 (n)
Species where no ortholog for XPOT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPOT Gene

ENSEMBL:
Gene Tree for XPOT (if available)
TreeFam:
Gene Tree for XPOT (if available)

Paralogs for XPOT Gene

Pseudogenes.org Pseudogenes for XPOT Gene

genes like me logo Genes that share paralogs with XPOT: view

No data available for Paralogs for XPOT Gene

Variants for XPOT Gene

Sequence variations from dbSNP and Humsavar for XPOT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000030326 -- 64,435,437(+) TTTTC(-/T)TTTTT intron-variant
rs1000182374 -- 64,428,391(+) GATGA(A/G)CTTGC intron-variant
rs1000204092 -- 64,417,907(+) AGTGG(C/T)ATTAT intron-variant
rs1000331263 -- 64,408,171(+) GTGGC(A/G)TGATC intron-variant
rs1000366052 -- 64,434,897(+) GATGC(A/C)CAAAC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for XPOT Gene

Variant ID Type Subtype PubMed ID
esv2745988 CNV deletion 23290073
esv3629773 CNV loss 21293372
nsv472434 CNV novel sequence insertion 20440878

Variation tolerance for XPOT Gene

Residual Variation Intolerance Score: 7.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XPOT Gene

Human Gene Mutation Database (HGMD)
XPOT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPOT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPOT Gene

Disorders for XPOT Gene

MalaCards: The human disease database

(2) MalaCards diseases for XPOT Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
12q14 microdeletion syndrome
  • del(12)(q14)
glaucoma, normal tension
  • low tension glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search XPOT in MalaCards View complete list of genes associated with diseases

Relevant External Links for XPOT

Genetic Association Database (GAD)
XPOT
Human Genome Epidemiology (HuGE) Navigator
XPOT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XPOT
genes like me logo Genes that share disorders with XPOT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPOT Gene

Publications for XPOT Gene

  1. Identification of a tRNA-specific nuclear export receptor. (PMID: 9660920) Kutay U … Görlich D (Molecular cell 1998) 2 3 4 22 60
  2. The role of exportin-t in selective nuclear export of mature tRNAs. (PMID: 9857198) Arts GJ … Mattaj IW (The EMBO journal 1998) 3 4 22 60
  3. Identification of a nuclear export receptor for tRNA. (PMID: 9512417) Arts GJ … Mattaj IW (Current biology : CB 1998) 2 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Interaction of immobilized human exportin-t with calf liver tRNA. (PMID: 17224653) Li S … Sprinzl M (RNA biology 2006) 3 22 60

Products for XPOT Gene

Sources for XPOT Gene

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