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Aliases for XPOT Gene

Aliases for XPOT Gene

  • Exportin For TRNA 2 3
  • Exportin, TRNA (Nuclear Export Receptor For TRNAs) 2 3
  • Exportin, TRNA 2 5
  • Exportin(TRNA) 3 4
  • TRNA Exportin 3 4
  • XPO3 3

External Ids for XPOT Gene

Previous GeneCards Identifiers for XPOT Gene

  • GC12U990131
  • GC07P055820
  • GC12P064514
  • GC12P063090
  • GC12P063084
  • GC12P064798
  • GC12P061850

Summaries for XPOT Gene

Entrez Gene Summary for XPOT Gene

  • This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

GeneCards Summary for XPOT Gene

XPOT (Exportin For TRNA) is a Protein Coding gene. Diseases associated with XPOT include low tension glaucoma. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot for XPOT Gene

  • Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for XPOT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPOT Gene

Genomics for XPOT Gene

Regulatory Elements for XPOT Gene

Promoters for XPOT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around XPOT on UCSC Golden Path with GeneCards custom track

Genomic Location for XPOT Gene

Chromosome:
12
Start:
64,404,350 bp from pter
End:
64,451,127 bp from pter
Size:
46,778 bases
Orientation:
Plus strand

Genomic View for XPOT Gene

Genes around XPOT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPOT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPOT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPOT Gene

Proteins for XPOT Gene

  • Protein details for XPOT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43592-XPOT_HUMAN
    Recommended name:
    Exportin-T
    Protein Accession:
    O43592
    Secondary Accessions:
    • A6NLH1
    • O43784
    • Q8WUG2
    • Q9BVS7

    Protein attributes for XPOT Gene

    Size:
    962 amino acids
    Molecular mass:
    109964 Da
    Quaternary structure:
    • Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner.

neXtProt entry for XPOT Gene

Proteomics data for XPOT Gene at MOPED

Post-translational modifications for XPOT Gene

  • Ubiquitination at Lys 557
  • Modification sites at PhosphoSitePlus

Other Protein References for XPOT Gene

Antibody Products

No data available for DME Specific Peptides for XPOT Gene

Domains & Families for XPOT Gene

Gene Families for XPOT Gene

Protein Domains for XPOT Gene

Suggested Antigen Peptide Sequences for XPOT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43592

UniProtKB/Swiss-Prot:

XPOT_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPOT: view

Function for XPOT Gene

Molecular function for XPOT Gene

GENATLAS Biochemistry:
exportin (tRNA),RanGTP-binding,importin beta-related factor with predominantly nuclear localization,specific mediator of tRNA export,shuttling between nucleus and cytoplasm and interacting with nuclear pore complexes (NPC)
UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with XPOT: view
genes like me logo Genes that share phenotypes with XPOT: view

Animal Models for XPOT Gene

MGI Knock Outs for XPOT:
  • Xpot tm3b(EUCOMM)Hmgu

Animal Model Products

miRNA for XPOT Gene

miRTarBase miRNAs that target XPOT

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XPOT Gene

Localization for XPOT Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPOT Gene

Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPOT Gene COMPARTMENTS Subcellular localization image for XPOT gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9660920
GO:0016363 nuclear matrix IBA --
genes like me logo Genes that share ontologies with XPOT: view

Pathways & Interactions for XPOT Gene

genes like me logo Genes that share pathways with XPOT: view

Pathways by source for XPOT Gene

1 KEGG pathway for XPOT Gene
1 Qiagen pathway for XPOT Gene

Gene Ontology (GO) - Biological Process for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0008033 tRNA processing TAS --
genes like me logo Genes that share ontologies with XPOT: view

No data available for SIGNOR curated interactions for XPOT Gene

Drugs & Compounds for XPOT Gene

(2) Drugs for XPOT Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for XPOT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XPOT: view

Transcripts for XPOT Gene

Unigene Clusters for XPOT Gene

Exportin, tRNA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XPOT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: - -
SP2:
SP3: - -
SP4: - - -
SP5: - -
SP6: -
SP7:
SP8:
SP9: -

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for XPOT Gene

GeneLoc Exon Structure for
XPOT
ECgene alternative splicing isoforms for
XPOT

Expression for XPOT Gene

mRNA expression in normal human tissues for XPOT Gene

Protein differential expression in normal tissues from HIPED for XPOT Gene

This gene is overexpressed in Bone (57.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPOT Gene



SOURCE GeneReport for Unigene cluster for XPOT Gene Hs.85951

genes like me logo Genes that share expression patterns with XPOT: view

Protein tissue co-expression partners for XPOT Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for XPOT Gene

Orthologs for XPOT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPOT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XPOT 35
  • 94.28 (n)
  • 99.06 (a)
XPOT 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPOT 35
  • 95.11 (n)
  • 99.27 (a)
XPOT 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpot 35
  • 87.01 (n)
  • 95.53 (a)
Xpot 16
Xpot 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XPOT 35
  • 99.76 (n)
  • 100 (a)
XPOT 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPOT 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XPOT 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves XPOT 35
  • 83.44 (n)
  • 93.87 (a)
XPOT 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPOT 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5914 35
xpot 35
  • 78.76 (n)
  • 88.05 (a)
zebrafish
(Danio rerio)
Actinopterygii xpot 35
  • 70.24 (n)
  • 78.44 (a)
xpot 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13873 35
worm
(Caenorhabditis elegans)
Secernentea xpo-3 35
  • 43.33 (n)
  • 28.54 (a)
xpo-3 36
  • 25 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR424C 35
  • 40.36 (n)
  • 24.73 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14036g 35
  • 43.39 (n)
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LOS1 35
  • 41.82 (n)
  • 23.18 (a)
LOS1 36
  • 19 (a)
OneToOne
LOS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PSD 35
  • 43.15 (n)
  • 29 (a)
rice
(Oryza sativa)
Liliopsida Os07g0613300 35
  • 42.5 (n)
  • 28.49 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11169 35
  • 41.52 (n)
  • 29.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes los1 35
  • 44.19 (n)
  • 29.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for XPOT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPOT Gene

ENSEMBL:
Gene Tree for XPOT (if available)
TreeFam:
Gene Tree for XPOT (if available)

Paralogs for XPOT Gene

Pseudogenes.org Pseudogenes for XPOT Gene

genes like me logo Genes that share paralogs with XPOT: view

No data available for Paralogs for XPOT Gene

Variants for XPOT Gene

Sequence variations from dbSNP and Humsavar for XPOT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17851795 - 64,425,819(+) GATGG(C/T)TTTCT nc-transcript-variant, reference, missense
rs1051396 - 64,431,709(+) CTGGA(C/G)GAAGA nc-transcript-variant, reference, missense
rs1137583 -- 64,449,084(+) CGGCT(A/G)CTCGG downstream-variant-500B, utr-variant-3-prime
rs7132741 -- 64,418,485(+) TTTTA(C/G)CTAAT intron-variant
rs7136076 -- 64,449,077(+) gtaat(C/G)ccggc downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for XPOT Gene

Variant ID Type Subtype PubMed ID
esv2745988 CNV Deletion 23290073

Variation tolerance for XPOT Gene

Residual Variation Intolerance Score: 7.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XPOT Gene

HapMap Linkage Disequilibrium report
XPOT
Human Gene Mutation Database (HGMD)
XPOT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPOT Gene

Disorders for XPOT Gene

MalaCards: The human disease database

(1) MalaCards diseases for XPOT Gene - From: DISEASES

Disorder Aliases PubMed IDs
low tension glaucoma
  • normal tension glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search XPOT in MalaCards View complete list of genes associated with diseases

Relevant External Links for XPOT

Genetic Association Database (GAD)
XPOT
Human Genome Epidemiology (HuGE) Navigator
XPOT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XPOT
genes like me logo Genes that share disorders with XPOT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPOT Gene

Publications for XPOT Gene

  1. Identification of a tRNA-specific nuclear export receptor. (PMID: 9660920) Kutay U. … Goerlich D. (Mol. Biol. Cell 1998) 2 3 4 23 67
  2. 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. (PMID: 16707848) Suzuki T. … Isemura M. (Biomed. Res. 2006) 3 23
  3. Interaction of immobilized human exportin-t with calf liver tRNA. (PMID: 17224653) Li S. … Sprinzl M. (RNA Biol 2006) 3 23
  4. Export and transport of tRNA are coupled to a multi-protein complex. (PMID: 10657246) Kruse C. … MA1ller P.K. (Biochem. J. 2000) 3 23
  5. Identification of a nuclear export receptor for tRNA. (PMID: 9512417) Arts G.-J. … Mattaj I.W. (Curr. Biol. 1998) 2 3

Products for XPOT Gene

Sources for XPOT Gene

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