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XPOT Gene

protein-coding   GIFtS: 63
GCID: GC12P064798

Exportin, TRNA

(Previous names: exportin, tRNA (nuclear export receptor for tRNAs))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exportin, TRNA1 2     exportin(tRNA)2
Exportin, TRNA (Nuclear Export Receptor For TRNAs)1 2     exportin-T2
TRNA Exportin2 3     Exportin(tRNA)3
XPO32     

External Ids:    HGNC: 128261   Entrez Gene: 112602   Ensembl: ENSG000001845757   OMIM: 6031805   UniProtKB: O435923   

Export aliases for XPOT gene to outside databases

Previous GC identifers: GC12U990131 GC07P055820 GC12P064514 GC12P063090 GC12P063084 GC12P061850


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XPOT Gene:
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the
nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and
GTP-bound RAN. (provided by RefSeq, Jul 2008)

GeneCards Summary for XPOT Gene:
XPOT (exportin, tRNA) is a protein-coding gene. GO annotations related to this gene include tRNA binding and Ran GTPase binding.

UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592
Function: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran
in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated
through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of
the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of
the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of
transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the
GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Gene Wiki entry for XPOT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the XPOT gene promoter:
         Sox5   Pbx1a   MyoD   Pax-2   CUTL1   Pax-2a   E47   N-Myc   ATF6   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPOT promoter sequence
   Search Chromatin IP Primers for XPOT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XPOT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.2   Ensembl cytogenetic band:  12q14.2   HGNC cytogenetic band: 12q14.1

XPOT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPOT gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P064798:  view genomic region     (about GC identifiers)

Start:
64,798,130 bp from pter      End:
64,844,907 bp from pter
Size:
46,778 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592 (See protein sequence)
Recommended Name: Exportin-T  
Size: 962 amino acids; 109964 Da
Subunit: Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with
Ran and tRNA in a GTP-dependent manner
Secondary accessions: A6NLH1 O43784 Q8WUG2 Q9BVS7

Explore the universe of human proteins at neXtProt for XPOT: NX_O43592

Explore proteomics data for XPOT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys557, Lys629, Lys634
  • Modification sites at PhosphoSitePlus

  • See XPOT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009166.2  
    ENSEMBL proteins: 
     ENSP00000327821   ENSP00000441376   ENSP00000383722   ENSP00000444345  

    XPOT Human Recombinant Protein Products:

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    Novus Biologicals XPOT Proteins
    Novus Biologicals XPOT Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for XPOT 

     
    antibodies-online proteins for XPOT (4 products) 

     
    antibodies-online peptides for XPOT

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    XPOT Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    antibodies-online kits for XPOT (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    XPO: Exportins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O43592

    ProtoNet protein and cluster: O43592

    1 Blocks protein domain: IPB013598 Exportin 1-like

    UniProtKB/Swiss-Prot: XPOT_HUMAN, O43592
    Similarity: Belongs to the exportin family


    Find genes that share domains with XPOT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPOT_HUMAN, O43592
    Function: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran
    in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated
    through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of
    the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of
    the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of
    transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the
    GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

         Genatlas biochemistry entry for XPOT:
    exportin (tRNA),RanGTP-binding,importin beta-related factor with predominantly nuclear localization,specific
    mediator of tRNA export,shuttling between nucleus and cytoplasm and interacting with nuclear pore complexes (NPC)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IDA9660920
    GO:0005488binding ----
    GO:0008536Ran GTPase binding IEA--
         
    Find genes that share ontologies with XPOT           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for XPOT:
     Increased Salmonella enterica   Increased Salmonella enterica  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for XPOT

    miRNA
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    miRTarBase miRNAs that target XPOT:
    hsa-mir-342-3p (MIRT043727), hsa-mir-16-5p (MIRT031897), hsa-mir-30a-5p (MIRT049957), hsa-mir-92a-3p (MIRT049726), hsa-mir-1 (MIRT023982)

    Block miRNA regulation of human, mouse, rat XPOT using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate XPOT:
    hsa-miR-3163 hsa-miR-1283 hsa-miR-891b hsa-miR-183 hsa-miR-340 hsa-miR-660
    SwitchGear 3'UTR luciferase reporter plasmidXPOT 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPOT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XPOT_HUMAN, O43592: Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the
    cytoplasm. Shuttles between the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005643colocalizes with nuclear pore IDA9660920
    GO:0005654nucleoplasm IDA9660920
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with XPOT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XPOT About    
    See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport
    2Ran Pathway
    Ran Pathway


    Find genes that share SuperPaths with XPOT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for XPOT
        Ran Pathway


    1 Kegg Pathway  (Kegg details for XPOT):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XPOT
    Interactions:

        Search GeneGlobe Interaction Network for XPOT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for XPOT (O435922, 3 ENSP000003278214) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48442 I2D: score=2 
    TNFRSF1AP194382, 3MINT-49330 I2D: score=2 
    TNFRSF1BP203332, 3MINT-49417 I2D: score=2 
    POLR3HQ9Y5353, ENSP000003473454I2D: score=6 STRING: ENSP00000347345
    RANP628263, ENSP000003961274I2D: score=5 STRING: ENSP00000396127
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006409tRNA export from nucleus IDA9660920
    GO:0006886intracellular protein transport IEA--

    Find genes that share ontologies with XPOT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XPOT

    1 HMDB Compound for XPOT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for XPOT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna 76.6 24 10199570 (5), 17224653 (2), 9857198 (1), 10657246 (1) (see all 6)
    calcitriol 43.3 3 16707848 (2), 16847355 (1)



    Find genes that share compounds with XPOT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XPOT gene: 
    NM_007235.4  

    Unigene Cluster for XPOT:

    Exportin, tRNA
    Hs.85951  [show with all ESTs]
    Unigene Representative Sequence: NM_007235
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332707(uc009zqm.2 uc001ssb.3) ENST00000540203 ENST00000400935
    ENST00000542958 ENST00000538086 ENST00000541842
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate XPOT:
    hsa-miR-3163 hsa-miR-1283 hsa-miR-891b hsa-miR-183 hsa-miR-340 hsa-miR-660
    SwitchGear 3'UTR luciferase reporter plasmidXPOT 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: XPOT (NM_007235)
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    OriGene qSTAR qPCR primer pairs in human, mouse for XPOT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XPOT
      QuantiTect SYBR Green Assays in human, mouse, rat XPOT
      QuantiFast Probe-based Assays in human, mouse, rat XPOT

    Additional mRNA sequence: 

    AF039022.1 AK292884.1 AK308108.1 BC000950.2 BC020569.1 Y16414.1 

    13 DOTS entries:

    DT.217287  DT.121043242  DT.121205831  DT.100823534  DT.120834106  DT.121205839  DT.91762614  DT.92035953 
    DT.95228395  DT.40197619  DT.91762627  DT.97762902  DT.97785147 

    Selected AceView cDNA sequences (see all 372):

    AI268316 BQ773198 CA416686 CN481709 AL120700 BQ026776 AL041511 AI769333 
    BQ215290 CD642924 BF797385 Y16414 BM662023 BM989569 AA256044 BI092883 
    AI582840 CA432790 CK821335 BM564749 CR613510 BI494977 CA420496 AI140173 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for XPOT (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
    SP1:                    -                                                                                                           -                           
    SP2:                                                                                                                                                            
    SP3:        -           -                                                                                                                                       
    SP4:        -           -                       -                                                                                                               
    SP5:                                                                                                              -                 -                           

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
    SP1:                                                            
    SP2:                                      -                     
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for XPOT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XPOT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGGTCCAAA
    XPOT Expression
    About this image

    XPOT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XPOT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.85951
        Custom PCR Arrays for XPOT
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    QuantiFast Probe-based Assays in human, mouse, rat XPOT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPOT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPOT gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpot1 , 5 exportin, tRNA (nuclear export receptor for tRNAs)1, 5 87.01(n)1
    95.53(a)1
      10 (69.86 cM)5
    731921  NM_001081056.11  NP_001074525.11 
     1215873805 
    chicken
    (Gallus gallus)
    Aves XPOT1 exportin, tRNA (nuclear export receptor for tRNAs) 83.44(n)
    93.87(a)
      417824  NM_001199606.1  NP_001186535.1 
    lizard
    (Anolis carolinensis)
    Reptilia XPOT6
    exportin, tRNA
    90(a)
    1 ↔ 1
    5(50489074-50509237)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.59142 Transcribed sequence with strong similarity to protein more 80.19(n)    AL965523.2 
    zebrafish
    (Danio rerio)
    Actinopterygii xpot1 exportin, tRNA (nuclear export receptor for tRNAs) 70.24(n)
    78.44(a)
      558020  NM_001044852.1  NP_001038317.1 
    worm
    (Caenorhabditis elegans)
    Secernentea xpo-31 xpo-3 43.33(n)
    28.54(a)
      177581  NM_068919.6  NP_501320.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LOS1(YKL205W)4
    LOS11
    Nuclear pore protein involved in nuclear export of more4
    LOS11
    41.82(n)1
    23.18(a)1
      11(50051-53353)4
    8536301, 4  NP_012717.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PSD1 PSD 43.15(n)
    29(a)
      843588  NM_105915.3  NP_177400.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g06133001 Os07g0613300 42.5(n)
    28.49(a)
      4343885  NM_001066790.1  NP_001060255.1 


    ENSEMBL Gene Tree for XPOT (if available)
    TreeFam Gene Tree for XPOT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for XPOT gene

    Find genes that share paralogs with XPOT           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for XPOT
    PGOHUM00000234963 PGOHUM00000247516 PGOHUM00000233250


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for XPOT (see all 866)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903320311,2
    --64796200(+) CACTCA/GCCCTC 1 -- us2k10--------
    rs286447731,2
    C,F--64796294(+) CAGATT/CGGGCC 1 -- us2k19Minor allele frequency- C:0.42WA NA CSA EA 370
    rs744435321,2
    F--64796465(+) GCAAGG/TATTAC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1815836761,2
    --64796479(+) CAAAAC/GAAAAT 1 -- us2k10--------
    rs1853451521,2
    --64796515(+) TATTTC/TGTTGG 1 -- us2k10--------
    rs1181411501,2
    F--64796602(+) AAGCTG/AAGGTG 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1162242791,2
    C,F--64796712(+) GCACCC/TGTAGT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1902045361,2
    --64796814(+) TAACAA/GAGCGA 1 -- us2k10--------
    rs1825506301,2
    --64796871(+) TAGCGA/CCATCT 1 -- us2k10--------
    rs1880620561,2
    --64796976(+) TCTTGA/GACAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for XPOT (64798130 - 64844907 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for XPOT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745988CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XPOT
    DNA2.0 Custom Variant and Variant Library Synthesis for XPOT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603180    OMIM disorders: --


    Find genes that share disorders with XPOT           About GenesLikeMe

    Genetic Association Database (GAD): XPOT
    Human Genome Epidemiology (HuGE) Navigator: XPOT (2 documents)

    Export disorders for XPOT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XPOT gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with XPOT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a tRNA-specific nuclear export receptor. (PubMed id 9660920)1, 2, 3, 9 Kutay U.... Goerlich D. (Mol. Biol. Cell 1998)
    2. Identification of a nuclear export receptor for tRNA. (PubMed id 9512417)1, 2, 3 Arts G.-J.... Mattaj I.W. (Curr. Biol. 1998)
    3. The role of exportin-t in selective nuclear export of mature tRNAs. (PubMed id 9857198)1, 2, 9 Arts G.-J.... Mattaj I.W. (EMBO J. 1998)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. (PubMed id 12138183)1, 2 Kuersten S.... Mattaj I.W. (Mol. Cell. Biol. 2002)
    7. Interaction of immobilized human exportin-t with calf liver tRNA. (PubMed id 17224653)1, 9 Li S. and Sprinzl M. (RNA Biol 2006)
    8. 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. (PubMed id 16707848)1, 9 Suzuki T....Isemura M. (Biomed. Res. 2006)
    9. Export and transport of tRNA are coupled to a multi-protein complex. (PubMed id 10657246)1, 9 Kruse C....MA1ller P.K. (Biochem. J. 2000)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11260 HGNC: 12826 AceView: XPOT Ensembl:ENSG00000184575 euGenes: HUgn11260
    ECgene: XPOT Kegg: 11260 H-InvDB: XPOT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for XPOT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XPOT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for XPOT gene:
    Search GeneIP for patents involving XPOT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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