Free for academic non-profit institutions. Other users need a Commercial license

Aliases for XPO7 Gene

Aliases for XPO7 Gene

  • Exportin 7 2 3 5
  • RAN Binding Protein 16 2 3
  • RANBP16 3 4
  • EXP7 3 4
  • Ran-Binding Protein 16 4
  • KIAA0745 4

External Ids for XPO7 Gene

Previous HGNC Symbols for XPO7 Gene

  • RANBP16

Previous GeneCards Identifiers for XPO7 Gene

  • GC08P022130
  • GC08P021597
  • GC08P021799
  • GC08P020319
  • GC08P021779

Summaries for XPO7 Gene

Entrez Gene Summary for XPO7 Gene

  • The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

GeneCards Summary for XPO7 Gene

XPO7 (Exportin 7) is a Protein Coding gene. GO annotations related to this gene include binding and nuclear export signal receptor activity. An important paralog of this gene is RANBP17.

UniProtKB/Swiss-Prot for XPO7 Gene

  • Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO7 Gene

Genomics for XPO7 Gene

Genomic Location for XPO7 Gene

Chromosome:
8
Start:
21,919,669 bp from pter
End:
22,006,585 bp from pter
Size:
86,917 bases
Orientation:
Plus strand

Genomic View for XPO7 Gene

Genes around XPO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO7 Gene

Proteins for XPO7 Gene

  • Protein details for XPO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIA9-XPO7_HUMAN
    Recommended name:
    Exportin-7
    Protein Accession:
    Q9UIA9
    Secondary Accessions:
    • O94846
    • Q6PJK9
    • Q8NEK7

    Protein attributes for XPO7 Gene

    Size:
    1087 amino acids
    Molecular mass:
    123907 Da
    Quaternary structure:
    • Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner.
    SequenceCaution:
    • Sequence=BAA34465.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for XPO7 Gene

Proteomics data for XPO7 Gene at MOPED

Post-translational modifications for XPO7 Gene

  • Ubiquitination at Lys 69
  • Modification sites at PhosphoSitePlus

Other Protein References for XPO7 Gene

No data available for DME Specific Peptides for XPO7 Gene

Domains & Families for XPO7 Gene

Gene Families for XPO7 Gene

Protein Domains for XPO7 Gene

Suggested Antigen Peptide Sequences for XPO7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIA9

UniProtKB/Swiss-Prot:

XPO7_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the exportin family.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO7: view

Function for XPO7 Gene

Molecular function for XPO7 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with XPO7: view
genes like me logo Genes that share phenotypes with XPO7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO7 Gene

Localization for XPO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO7 Gene

Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPO7 Gene COMPARTMENTS Subcellular localization image for XPO7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11071879
genes like me logo Genes that share ontologies with XPO7: view

Pathways & Interactions for XPO7 Gene

SuperPathways for XPO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA 11024021
genes like me logo Genes that share ontologies with XPO7: view

No data available for Pathways by source and SIGNOR curated interactions for XPO7 Gene

Drugs & Compounds for XPO7 Gene

(1) Drugs for XPO7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with XPO7: view

Transcripts for XPO7 Gene

Unigene Clusters for XPO7 Gene

Exportin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XPO7 Gene

No ASD Table

Relevant External Links for XPO7 Gene

GeneLoc Exon Structure for
XPO7
ECgene alternative splicing isoforms for
XPO7

Expression for XPO7 Gene

mRNA expression in normal human tissues for XPO7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for XPO7 Gene

This gene is overexpressed in Bone (44.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPO7 Gene



SOURCE GeneReport for Unigene cluster for XPO7 Gene Hs.172685

mRNA Expression by UniProt/SwissProt for XPO7 Gene

Q9UIA9-XPO7_HUMAN
Tissue specificity: Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.
genes like me logo Genes that share expression patterns with XPO7: view

Protein tissue co-expression partners for XPO7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for XPO7 Gene

Orthologs for XPO7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XPO7 35
  • 93.56 (n)
  • 99.91 (a)
XPO7 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO7 35
  • 95.01 (n)
  • 99.91 (a)
XPO7 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo7 35
  • 91.78 (n)
  • 99.45 (a)
Xpo7 16
Xpo7 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XPO7 35
  • 99.82 (n)
  • 100 (a)
XPO7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xpo7 35
  • 92.12 (n)
  • 99.36 (a)
oppossum
(Monodelphis domestica)
Mammalia XPO7 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XPO7 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves XPO7 35
  • 84.76 (n)
  • 98.9 (a)
XPO7 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpo7 35
  • 77.37 (n)
  • 93.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2294 35
zebrafish
(Danio rerio)
Actinopterygii xpo7 35
  • 80.13 (n)
  • 96.69 (a)
xpo7 36
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004535 35
  • 60.46 (n)
  • 61.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp16 35
  • 58.91 (n)
  • 59.94 (a)
Ranbp16 36
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35A5.8 35
  • 49.16 (n)
  • 43.57 (a)
C35A5.8 36
  • 42 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06120 35
  • 51.84 (n)
  • 46.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for XPO7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO7 Gene

ENSEMBL:
Gene Tree for XPO7 (if available)
TreeFam:
Gene Tree for XPO7 (if available)

Paralogs for XPO7 Gene

Paralogs for XPO7 Gene

(2) SIMAP similar genes for XPO7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with XPO7: view

Variants for XPO7 Gene

Sequence variations from dbSNP and Humsavar for XPO7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs17856894 - 21,982,729(+) ACAGA(C/G)CCCCA reference, missense
rs17856895 - 21,999,166(+) CATCT(A/G)CTTCT reference, missense
rs7220 -- 22,005,779(+) ACCGT(A/G)TAGAT utr-variant-3-prime
rs15168 -- 22,006,413(+) TTTTT(A/T)TTTCT utr-variant-3-prime
rs727693 -- 21,992,605(-) TGCCA(C/T)TGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPO7 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv8319 CNV Gain 18304495
esv2736744 CNV Deletion 23290073

Variation tolerance for XPO7 Gene

Residual Variation Intolerance Score: 2.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XPO7 Gene

HapMap Linkage Disequilibrium report
XPO7
Human Gene Mutation Database (HGMD)
XPO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO7 Gene

Disorders for XPO7 Gene

Relevant External Links for XPO7

Genetic Association Database (GAD)
XPO7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XPO7

No disorders were found for XPO7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XPO7 Gene

Publications for XPO7 Gene

  1. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PMID: 11024021) Kutay U. … Bischoff F.R. (J. Biol. Chem. 2000) 2 3 4 67
  2. STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7. (PMID: 18256292) Dorfman J. … Macara I.G. (Mol. Biol. Cell 2008) 3 23
  3. Exportin 7 defines a novel general nuclear export pathway. (PMID: 15282546) Mingot J.-M. … Goerlich D. (EMBO J. 2004) 3 23
  4. Identification of a novel putative Ran-binding protein and its close homologue. (PMID: 11071879) Koch P. … Janssen J.W.G. (Biochem. Biophys. Res. Commun. 2000) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3

Products for XPO7 Gene

Sources for XPO7 Gene

Back to Top

Content