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Aliases for XPO7 Gene

Aliases for XPO7 Gene

  • Exportin 7 2 3 5
  • RAN Binding Protein 16 2 3
  • RANBP16 3 4
  • EXP7 3 4
  • Ran-Binding Protein 16 4
  • Exportin-7 3
  • KIAA0745 4

External Ids for XPO7 Gene

Previous HGNC Symbols for XPO7 Gene

  • RANBP16

Previous GeneCards Identifiers for XPO7 Gene

  • GC08P022130
  • GC08P021597
  • GC08P021799
  • GC08P020319
  • GC08P021779

Summaries for XPO7 Gene

Entrez Gene Summary for XPO7 Gene

  • The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

GeneCards Summary for XPO7 Gene

XPO7 (Exportin 7) is a Protein Coding gene. GO annotations related to this gene include binding and nuclear export signal receptor activity. An important paralog of this gene is RANBP17.

UniProtKB/Swiss-Prot for XPO7 Gene

  • Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO7 Gene

Genomics for XPO7 Gene

Regulatory Elements for XPO7 Gene

Enhancers for XPO7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G021958 1.3 Ensembl ENCODE 12.6 +40.5 40488 3.2 PKNOX1 ARNT WRNIP1 JUNB REST TBX21 SMARCB1 ZNF592 MEF2D SMARCA4 XPO7 GFRA2 GC08M021982 GC08P021924
GH08G022700 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +783.6 783605 6.0 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 BIN3 XPO7 NPM2 TNFRSF10C PDLIM2 TNFRSF10B PPP3CC EGR3 GC08P022700 GC08M022705
GH08G021971 0.8 ENCODE 12.2 +51.8 51768 0.8 HDAC1 ATF1 JUN CEBPG RELA FOSL1 NCOR1 PRDM10 CREM SMARCE1 XPO7 NPM2 FGF17 GC08M021982 GC08P021924
GH08G022164 1.6 Ensembl ENCODE dbSUPER 5.8 +248.1 248084 6.8 FOXA2 CREB3L1 MLX SIN3A ARID4B DMAP1 ZNF766 ZNF143 ZNF548 KLF13 BMP1 C8orf58 ENSG00000253200 LOC107986927 SORBS3 REEP4 NPM2 POLR3D LOC101929237 XPO7
GH08G022190 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +273.2 273150 4.6 MLX RB1 ZNF133 ARID4B ZNF335 GLIS2 EGR1 FOS EGR2 SMARCA5 BMP1 PPP3CC XPO7 DOK2 LOC105379319 PHYHIP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XPO7 on UCSC Golden Path with GeneCards custom track

Promoters for XPO7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221975 231 1801 HDGF HNRNPUL1 ATF1 FOXA2 CREB3L1 ARID4B SIN3A YY1 GLIS2 ZNF143
ENSR00000330254 -1268 400 HDGF PKNOX1 ATF1 CREB3L1 ZFP64 WRNIP1 SIN3A ETS1 ELK1 ZNF143

Genomic Location for XPO7 Gene

Chromosome:
8
Start:
21,919,669 bp from pter
End:
22,006,585 bp from pter
Size:
86,917 bases
Orientation:
Plus strand

Genomic View for XPO7 Gene

Genes around XPO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO7 Gene

Proteins for XPO7 Gene

  • Protein details for XPO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIA9-XPO7_HUMAN
    Recommended name:
    Exportin-7
    Protein Accession:
    Q9UIA9
    Secondary Accessions:
    • O94846
    • Q6PJK9
    • Q8NEK7

    Protein attributes for XPO7 Gene

    Size:
    1087 amino acids
    Molecular mass:
    123907 Da
    Quaternary structure:
    • Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner.
    SequenceCaution:
    • Sequence=BAA34465.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for XPO7 Gene

Post-translational modifications for XPO7 Gene

  • Ubiquitination at Lys69
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for XPO7 Gene

Domains & Families for XPO7 Gene

Gene Families for XPO7 Gene

Protein Domains for XPO7 Gene

Suggested Antigen Peptide Sequences for XPO7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIA9

UniProtKB/Swiss-Prot:

XPO7_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO7: view

Function for XPO7 Gene

Molecular function for XPO7 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005049 nuclear export signal receptor activity IDA 11024021
GO:0005515 protein binding IPI 25416956
GO:0008536 Ran GTPase binding IBA,IEA --
genes like me logo Genes that share ontologies with XPO7: view
genes like me logo Genes that share phenotypes with XPO7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO7 Gene

Localization for XPO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO7 Gene

Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPO7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 11071879
GO:0005643 nuclear pore IEA,IDA 11024021
GO:0005737 cytoplasm IEA,IDA 11071879
genes like me logo Genes that share ontologies with XPO7: view

Pathways & Interactions for XPO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA 11024021
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with XPO7: view

No data available for Pathways by source and SIGNOR curated interactions for XPO7 Gene

Drugs & Compounds for XPO7 Gene

(1) Drugs for XPO7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with XPO7: view

Transcripts for XPO7 Gene

Unigene Clusters for XPO7 Gene

Exportin 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO7 Gene

No ASD Table

Relevant External Links for XPO7 Gene

GeneLoc Exon Structure for
XPO7
ECgene alternative splicing isoforms for
XPO7

Expression for XPO7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XPO7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for XPO7 Gene

This gene is overexpressed in Bone (44.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XPO7 Gene



Protein tissue co-expression partners for XPO7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XPO7 Gene:

XPO7

SOURCE GeneReport for Unigene cluster for XPO7 Gene:

Hs.172685

mRNA Expression by UniProt/SwissProt for XPO7 Gene:

Q9UIA9-XPO7_HUMAN
Tissue specificity: Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.

Evidence on tissue expression from TISSUES for XPO7 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(4.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with XPO7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO7 Gene

Orthologs for XPO7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO7 34 35
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia XPO7 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO7 34 35
  • 95.01 (n)
cow
(Bos Taurus)
Mammalia XPO7 34 35
  • 93.56 (n)
rat
(Rattus norvegicus)
Mammalia Xpo7 34
  • 92.12 (n)
mouse
(Mus musculus)
Mammalia Xpo7 34 16 35
  • 91.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia XPO7 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves XPO7 34 35
  • 84.76 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia xpo7 34
  • 77.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2294 34
zebrafish
(Danio rerio)
Actinopterygii xpo7 34 35
  • 80.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004535 34
  • 60.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp16 34 35
  • 58.91 (n)
worm
(Caenorhabditis elegans)
Secernentea C35A5.8 34 35
  • 49.16 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06120 34
  • 51.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToMany
Species where no ortholog for XPO7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO7 Gene

ENSEMBL:
Gene Tree for XPO7 (if available)
TreeFam:
Gene Tree for XPO7 (if available)

Paralogs for XPO7 Gene

Paralogs for XPO7 Gene

(2) SIMAP similar genes for XPO7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with XPO7: view

Variants for XPO7 Gene

Sequence variations from dbSNP and Humsavar for XPO7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000007426 -- 21,919,730(+) GCGCT(A/G/T)GGGGG nc-transcript-variant, utr-variant-5-prime
rs1000049065 -- 21,955,769(+) CTGTC(C/T)CCAGG intron-variant
rs1000059439 -- 21,988,954(+) GAAAC(C/T)AGCAA intron-variant
rs1000143429 -- 22,002,518(+) TGTCT(C/G)ATGAT intron-variant
rs1000235806 -- 21,918,374(+) TCTAT(A/G)CTCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for XPO7 Gene

Variant ID Type Subtype PubMed ID
dgv7131n100 CNV gain 25217958
dgv7132n100 CNV gain 25217958
dgv7133n100 CNV gain 25217958
dgv7134n100 CNV gain 25217958
dgv7135n100 CNV loss 25217958
esv2736744 CNV deletion 23290073
esv2759604 CNV loss 17122850
esv3383227 CNV duplication 20981092
nsv1019785 CNV gain+loss 25217958
nsv1023009 CNV gain 25217958
nsv1032771 CNV loss 25217958
nsv8319 CNV gain 18304495

Variation tolerance for XPO7 Gene

Residual Variation Intolerance Score: 2.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XPO7 Gene

Human Gene Mutation Database (HGMD)
XPO7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO7 Gene

Disorders for XPO7 Gene

Relevant External Links for XPO7

Genetic Association Database (GAD)
XPO7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XPO7

No disorders were found for XPO7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XPO7 Gene

Publications for XPO7 Gene

  1. Exportin 7 defines a novel general nuclear export pathway. (PMID: 15282546) Mingot J.-M. … Goerlich D. (EMBO J. 2004) 3 4 22 64
  2. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PMID: 11024021) Kutay U. … Bischoff F.R. (J. Biol. Chem. 2000) 2 3 4 64
  3. Identification of a novel putative Ran-binding protein and its close homologue. (PMID: 11071879) Koch P. … Janssen J.W.G. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  5. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 46 64

Products for XPO7 Gene

Sources for XPO7 Gene

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