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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XPO7 Gene

protein-coding   GIFtS: 53
GCID: GC08P021779

Exportin 7

(Previous name: RAN binding protein 16)
(Previous symbol: RANBP16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Exportin 71 2     EXP72
RANBP161 2 3 5     exportin-72
RAN Binding Protein 161 2     Exp73
KIAA07453 5     Ran-Binding Protein 163

External Ids:    HGNC: 141081   Entrez Gene: 230392   Ensembl: ENSG000001302277   OMIM: 6061405   UniProtKB: Q9UIA93   

Export aliases for XPO7 gene to outside databases

Previous GC identifers: GC08P022130 GC08P021597 GC08P021799 GC08P021833 GC08P020319


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XPO7 Gene:
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and
regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition
of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738.
The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a
member of the importin-beta superfamily of nuclear transport receptors.(supplied by OMIM, Jul 2002)

GeneCards Summary for XPO7 Gene: 
XPO7 (exportin 7) is a protein-coding gene. Diseases associated with XPO7 include hemolytic anemia, and anemia. GO annotations related to this gene include nuclear export signal receptor activity. An important paralog of this gene is RANBP17.

UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9
Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds
cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex
to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export
complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1
and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear
compartment and mediate another round of transport. The directionality of nuclear export is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XPO7 gene promoter:
         NRSF form 1   Lmo2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   RelA   Nkx2-5   NRSF form 2   GATA-2   SRY   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPO7 promoter sequence
   Search SABiosciences Chromatin IP Primers for XPO7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPO7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21

XPO7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P021779:  view genomic region     (about GC identifiers)

Start:
21,777,180 bp from pter      End:
21,864,096 bp from pter
Size:
86,917 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9 (See protein sequence)
Recommended Name: Exportin-7  
Size: 1087 amino acids; 123907 Da
Subunit: Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.
Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner
Subcellular location: Cytoplasm. Nucleus (Probable). Nucleus, nuclear pore complex (Probable). Note=Shuttles
between the nucleus and the cytoplasm (Probable)
Sequence caution: Sequence=BAA34465.1; Type=Erroneous initiation;
Secondary accessions: O94846 Q6PJK9 Q8NEK7

Explore the universe of human proteins at neXtProt for XPO7: NX_Q9UIA9

Explore proteomics data for XPO7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UIA9

  • XPO7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    XPO7 Protein Expression
    REFSEQ proteins: NP_055839.3  
    ENSEMBL proteins: 
     ENSP00000252512   ENSP00000429290   ENSP00000410249   ENSP00000429317   ENSP00000404853  

    Human Recombinant Protein Products for XPO7: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XPO7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11071879
    GO:0005643nuclear pore IDA11024021
    GO:0005737cytoplasm IDA11071879

    XPO7 for ontologies           About GeneDecksing



    XPO7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    XPO: Exportins

    2 InterPro protein domains:
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9UIA9

    ProtoNet protein and cluster: Q9UIA9

    1 Blocks protein domain: IPB001494 Importin-beta

    UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9
    Similarity: Belongs to the exportin family
    Similarity: Contains 1 importin N-terminal domain


    XPO7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPO7_HUMAN, Q9UIA9
    Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds
    cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex
    to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export
    complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1
    and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear
    compartment and mediate another round of transport. The directionality of nuclear export is thought to be
    conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005049nuclear export signal receptor activity IDA11024021
    GO:0005488binding ----
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ----
         
    XPO7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for XPO7:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for XPO7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XPO7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XPO7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XPO7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XPO7
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate XPO7 (see all 32):
    hsa-miR-3607-3p hsa-miR-3664-5p hsa-miR-300 hsa-miR-15a hsa-miR-624 hsa-miR-424 hsa-miR-15b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidXPO7 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of XPO7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XPO7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/24 Interacting proteins for XPO7 (Q9UIA92, 3 ENSP000004048534) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK9P459842, 3, ENSP000003214104MINT-64910 I2D: score=3 STRING: ENSP00000321410
    IKBKGQ9Y6K92, 3MINT-48232 I2D: score=2 
    PDPK1O155302, 3MINT-8265643 I2D: score=2 
    TAB1Q157502, 3MINT-8260405 I2D: score=2 
    C20orf24Q9BUV83, ENSP000003412134I2D: score=2 STRING: ENSP00000341213
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006611protein export from nucleus IDA11024021
    GO:0006886intracellular protein transport ----
    GO:0051028mRNA transport IEA--

    XPO7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XPO7

    1 HMDB Compound for XPO7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about XPO7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for XPO7 gene (3 alternative transcripts): 
    NM_001100161.1  NM_001100162.1  NM_015024.4  

    Unigene Cluster for XPO7:

    Exportin 7
    Hs.172685  [show with all ESTs]
    Unigene Representative Sequence: NM_015024
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252512 ENST00000521303 ENST00000519769 ENST00000518017(uc010ltj.1)
    ENST00000520754 ENST00000433566 ENST00000518808 ENST00000517551 ENST00000522015
    ENST00000434536(uc003xaa.4)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XPO7
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate XPO7 (see all 32):
    hsa-miR-3607-3p hsa-miR-3664-5p hsa-miR-300 hsa-miR-15a hsa-miR-624 hsa-miR-424 hsa-miR-15b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidXPO7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for XPO7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XPO7
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO7
    Sirion Biotech Customized lentivirus for stable overexpression of XPO7 
                         Customized lentivirus expression plasmids for stable overexpression of XPO7 
    Primer
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    OriGene qPCR primer pairs and template standards for XPO7
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPO7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPO7

    Additional mRNA sequence: 

    AB018288.1 AF064729.1 AK291472.1 AK299848.1 AK311616.1 BC014219.2 BC030785.1 

    16 DOTS entries:

    DT.97780897  DT.95310524  DT.92439446  DT.75106176  DT.100641107  DT.95300785  DT.95310531  DT.100706600 
    DT.92017852  DT.92439443  DT.100781425  DT.104689  DT.121489919  DT.121489938  DT.92439455  DT.121489934 

    24/405 AceView cDNA sequences (see all 405):

    AL517549 AL698853 N90414 AL044691 W19680 BC014219 AA883234 AA552127 
    AI283256 AA701943 BM561817 AA972097 CN479571 BM465733 C01267 AA384679 
    AA858118 AA282083 BU153086 AW130435 AA236543 AA235389 AA232733 AI089271 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XPO7 expression in normal human tissues (normalized intensities)      XPO7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    XPO7 Expression
    About this image


    XPO7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Proerythroblasts Hematopoietic Bone Marrow
             Umbilical cord blood-derived hematopoietic stem cells
             cd3+ t cells   
     
     Spleen (Hematopoietic System)
             splenocytes   
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived hematopoietic stem cells
     
     Bone (Muscoskeletal System)
             bone marrow   
     
     Testis (Reproductive System)

    See XPO7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XPO7

    SOURCE GeneReport for Unigene cluster: Hs.172685

    UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9
    Tissue specificity: Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small
    intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red
    blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic
    anemia of unknown etiology

        SABiosciences Custom PCR Arrays for XPO7
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPO7 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpo71 , 5 exportin 71, 5 91.78(n)1
    99.45(a)1
      14 (36.44 cM)5
    652461  NM_023045.21  NP_075532.11 
     706542465 
    chicken
    (Gallus gallus)
    Aves XPO71 exportin 7 84.76(n)
    98.9(a)
      426925  NM_001012942.1  NP_001012960.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.22942 Xenopus laevis transcribed sequence with strong similarity more 81.25(n)    CF288280.1 
    zebrafish
    (Danio rerio)
    Actinopterygii xpo71 exportin 7 80.13(n)
    96.69(a)
      407710  NM_001128230.1  NP_001121702.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ranbp161 CG33180-PB 58.91(n)
    59.94(a)
      118436  NM_001201667.1  NP_001188596.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C35A5.81 Protein C35A5.8 48.97(n)
    43.13(a)
      179467  NM_073297.4  NP_505698.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G061201 armadillo/beta-catenin-like repeat-containing protein 51.35(n)
    45.56(a)
      830499  NM_001203306.1  NP_001190235.1 


    ENSEMBL Gene Tree for XPO7 (if available)
    TreeFam Gene Tree for XPO7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for XPO7 gene
    RANBP172  
    2 SIMAP similar genes for XPO7 using alignment to 6 protein entries:     XPO7_HUMAN (see all proteins):
    RANBP17    DKFZp666P032

    XPO7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1898 SNPs in XPO7 are shown (see all 1898)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69935401,2
    C,F--20317900(+) aggccA/Tcttaa 1 -- us2k16Minor allele frequency- T:0.23NA WA CSA 128
    rs784503761,2
    F--20317922(+) AGGAGT/CGTAAA 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1449126711,2
    --21775186(+) GGCAAG/TAGAAT 1 -- us2k10--------
    rs70096931,2
    C,F,A,H--21775314(+) gcagcA/Gtccag 1 -- us2k128Minor allele frequency- G:0.43NS EA NA WA CSA 2777
    rs1475440411,2
    --21775478(+) AGATAC/TAGATT 1 -- us2k10--------
    rs1824083171,2
    --21775587(+) CATTTA/CCTGAG 1 -- us2k10--------
    rs1400809961,2
    --21775618(+) AACACA/GGGGAG 1 -- us2k10--------
    rs1456002991,2
    C--21775741(+) ATTGTC/GACTCT 1 -- us2k10--------
    rs563170711,2
    C,F--21775838(+) ACGCTG/CGGAGG 1 -- us2k18Minor allele frequency- C:0.10WA NA CSA EA 368
    rs1453577311,2
    --21775876(+) CTGAAA/CAGGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for XPO7 (21777180 - 21864096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for XPO7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2736744CNV Deletion23290073
    nsv8319CNV Gain18304495
    essv21913CNV CNV17122850
    essv19243CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606140    OMIM disorders: --

    3 diseases for XPO7:    About MalaCards
    hemolytic anemia    anemia    thyroiditis


    XPO7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): XPO7

    Export disorders for XPO7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XPO7 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with XPO7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PubMed id 11024021)1, 2, 3 Kutay U.... Bischoff F.R. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    3. Exportin 7 defines a novel general nuclear export pathway. (PubMed id 15282546)1, 2, 9 Mingot J.-M.... Goerlich D. (2004)
    4. Identification of a novel putative Ran-binding protein and its close homologue. (PubMed id 11071879)1, 2, 9 Koch P.... Janssen J.W.G. (2000)
    5. Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. STRAD{alpha} Regulates LKB1 Localization by Blocking Access to Importin-{alpha}, and by Association with Crm1 and Exportin-7. (PubMed id 18256292)1, 9 Dorfman J. and Macara I.G. (2008)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE). (PubMed id 22509282)2 von Lohneysen K.... Friedman J.S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23039 HGNC: 14108 AceView: XPO7 Ensembl:ENSG00000130227 euGenes: HUgn23039
    ECgene: XPO7 H-InvDB: XPO7

    (According to HUGE)
    About This Section
    HUGE: KIAA0745

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XPO7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for XPO7 gene:
    Search GeneIP for patents involving XPO7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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