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Aliases & Descriptions for XPO7
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases Exp7 3 KIAA0745 1 , 2 , 3 , 5 RANBP16 2 , 3 , 5
Descriptions RAN binding protein 16 1 , 2 Ran-binding protein 16 3 exportin 7 2
Search outside databases for aliases for XPO7 genePrevious GC identifers: GC08P022130 GC08P021597 GC08P021799
Summaries for XPO7 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for XPO7 : The transport of protein and large RNAs through the nuclear pore complexes (NPC) is anenergy-dependent and regulated process. The import of proteins with a nuclear localization signal(NLS) is accomplished by recognition of one or more clusters of basic amino acids by theimportin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179)plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of theimportin-beta superfamily of nuclear transport receptors.[supplied by OMIM] UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9 Function : Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In thenucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form.Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding tonucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of thecomplex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) causerelease of the cargo from the export receptor. XPO7 then return to the nuclear compartment andmediate another round of transport. The directionality of nuclear export is thought to beconferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between thecytoplasm and nucleus
Genomic Location for XPO7
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the XPO7 gene Entrez Gene cytogenetic band: 8p21 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21 XPO7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08P021833:
(about GC identifiers )
Start:
21,833,126 bp from pter
End:
21,920,042 bp from pter
Size:
86,917 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000008.9 NT_023666.17 Proteins for XPO7
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9 (See
protein sequence )Recommended Name: Exportin-7 Size : 1087 amino acids; 123907 Da
Subunit : Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependentmanner
Subcellular location : Cytoplasm (Probable). Nucleus (Probable). Nucleus, nuclear pore complex(Probable). Note=Shuttles between the nucleus and the cytoplasm (Probable)
Secondary accessions : O94846 Q6PJK9 Q8NEK7
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001093631.1 NP_001093632.1 NP_055839.3 ENSEMBL proteins: ENSP00000252512 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for XPO7: Assays for XPO7:
Protein
Domains/ Families for XPO7(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UIA9 ProtoNet protein and cluster: Q9UIA9
1 Blocks protein family : IPB001494 Importin-beta UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9 Similarity : Belongs to the exportin familySimilarity : Contains 1 importin N-terminal domain
Gene Function for XPO7
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
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Millipore ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_015024 Applied Biosystems Silencer ® siRNAs for XPO7 Sigma-Aldrich siRNA for XPO7 Sigma-Aldrich shRNA for XPO7 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001100161                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001100161                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001100161  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001100161 UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9 Function : Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In thenucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form.Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding tonucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of thecomplex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) causerelease of the cargo from the export receptor. XPO7 then return to the nuclear compartment andmediate another round of transport. The directionality of nuclear export is thought to beconferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between thecytoplasm and nucleus
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005049 nuclear export signal receptor activity
IDA 11024021 GO:0008565 protein transporter activity
IEA --
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Pathways & Interactions for XPO7
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/42 Interacting proteins for XPO7 (Q9UIA9 1 , 2 ENSP00000252512 3 ) via UniProtKB, MINT, and/or STRING (see all 42
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for XPO7 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for XPO7
Transcripts for XPO7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_015024 Sigma-Aldrich siRNA for XPO7 Sigma-Aldrich shRNA for XPO7 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001100161 NM_001100162 NM_015024
REFSEQ mRNAs for XPO7 gene (3 alternative transcripts): NM_001100161.1 NM_001100162.1 NM_015024.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001100161 NM_001100162 NM_015024
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001100161                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001100161                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001100161  
Additional cDNA sequence: AB018288.1 AF064729.1 AK291472.1 AK299848.1 AK311616.1 BC014219.2 BC030785.1
16 DOTS entries : DT.97780897 DT.95310524 DT.92439446 DT.75106176 DT.100641107 DT.95300785 DT.100706600 DT.95310531 DT.92017852 DT.92439443 DT.100781425 DT.104689 DT.121489919 DT.121489934 DT.121489938 DT.92439455
24/405 AceView cDNA sequences (see all 405
):N79026 AA701943 BQ010451 C01267 AW130435 AW131378 H54683 AA232733 BM465733 BM786671 W19680 AA761468 BE275239 AI205301 R93525 F10605 N90414 BC014219 AA282083 BM561817 AA236543 AA235389 AA883234 AL044691
highest scoring ESTs for XPO7 :AA091303 AA203698 AA410681 AA448490 AB018288 AF064729 AI024188 AI431948 AL044691 AL563597
Unigene Cluster for XPO7: Exportin 7 Hs.172685 [show with all ESTs ] Unigene Representative Sequence: NM_001100161 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000252512
Expression for XPO7
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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XPO7 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for XPO7 1 / 2 / 3
5 probe-sets matching XPO7 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.172685 Expression variation in blood from EXPOLDB for XPO7
UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9 Tissue specificity : Strong expression in testis, thyroid and bone marrow, low expression in lung,liver and small intestine, no expression in thymus, and remaining tissues studied have moderateexpression
Orthologs for XPO7
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for XPO7 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for XPO7 ENSEMBL Gene Tree for XPO7 Paralogs for XPO7 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for XPO7 gene RANBP17 2 XPO4 2
SNPs/Variants for XPO7 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for XPO7 (up to first 250kb)
Disorders & Mutations for XPO7
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606140
Medical News for XPO7 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for XPO7 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/11 PubMed articles for XPO7 gene (see all 11
): Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PubMed id 11024021) 2, 3, 4 Kutay U.... Bischoff F.R. (2000) Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452) 2, 3, 4 Nagase T....Ohara O. (1998) Exportin 7 defines a novel general nuclear export pathway. (PubMed id 15282546) 1, 3, 4 Mingot J.-M.... Goerlich D. (2004) Identification of a novel putative Ran-binding protein and its close homologue. (PubMed id 11071879) 1, 3, 4 Koch P.... Janssen J.W.G. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) STRAD{alpha} Regulates LKB1 Localization by Blocking Access to Importin-{alpha}, and by Association with Crm1 and Exportin-7. (PubMed id 18256292) 1, 3 Dorfman J. and Macara I.G. (2008) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107) 4 Rikova K....Comb M.J. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931) 3 Ewing R.M....Figeys D. (2007) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 3 Stelzl U....Wanker E.E. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing XPO7
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing XPO7
(According to HUGE )
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Specialized Databases showing XPO7 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for XPO7 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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