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XPO7 Gene

protein-coding   GIFtS: 54

GC08P021833
exportin 7
(Previous name: RAN binding protein 16 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RANBP16)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
Exp7 3
KIAA0745 1, 2, 3, 5
RANBP16 2, 3, 5
Descriptions
RAN binding protein 16 1, 2
Ran-binding protein 16 3
exportin 7 2
External Ids
HGNC: 141081
Entrez Gene: 230392
UniProtKB: Q9UIA93
Ensembl: ENSG000001302277
Search outside databases for aliases for XPO7 gene

Previous GC identifers: GC08P022130 GC08P021597 GC08P021799

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for XPO7:
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an
energy-dependent and regulated process. The import of proteins with a nuclear localization signal
(NLS) is accomplished by recognition of one or more clusters of basic amino acids by the
importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179)
plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the
importin-beta superfamily of nuclear transport receptors.[supplied by OMIM]

UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9
Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the
nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form.
Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to
nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the
complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause
release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and
mediate another round of transport. The directionality of nuclear export is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
cytoplasm and nucleus

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XPO7 gene  

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21

XPO7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P021833:     (about GC identifiers)

Start:
21,833,126 bp from pter
End:
21,920,042 bp from pter
Size:
86,917 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_023666.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9 (See protein sequence)
Recommended Name: Exportin-7  
Size: 1087 amino acids; 123907 Da
Subunit: Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35
and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent
manner
Subcellular location: Cytoplasm (Probable). Nucleus (Probable). Nucleus, nuclear pore complex
(Probable). Note=Shuttles between the nucleus and the cytoplasm (Probable)
Secondary accessions: O94846 Q6PJK9 Q8NEK7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001093631.1  NP_001093632.1  NP_055839.3  


    ENSEMBL proteins: 
    ENSP00000252512 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RanBP16)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA11071879
    GO:0005643 nuclear pore IDA11024021
    GO:0005737 cytoplasm IDA11071879
    About this table

    Antibodies for XPO7: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for XPO7
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (RanBP16), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (XPO7)
    Novus Biologicals Antibody for XPO7

    Assays for XPO7: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR001494 Importin-b_N


       GeneDecks  XPO7 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UIA9

    ProtoNet protein and cluster: Q9UIA9

    1 Blocks protein family: IPB001494 Importin-beta

    UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9
    Similarity: Belongs to the exportin family
    Similarity: Contains 1 importin N-terminal domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XPO7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XPO7)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_015024

                  Applied Biosystems Silencer® siRNAs for XPO7

                  Sigma-Aldrich siRNA for XPO7  
                         Sigma-Aldrich shRNA for XPO7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for XPO7
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001100161
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001100161
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001100161 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001100161

    UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9
    Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the
    nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form.
    Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to
    nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the
    complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause
    release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and
    mediate another round of transport. The directionality of nuclear export is thought to be
    conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
    cytoplasm and nucleus

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005049 nuclear export signal receptor activity IDA11024021
    GO:0008565 protein transporter activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/42 Interacting proteins for XPO7 (Q9UIA91, 2 ENSP000002525123) via UniProtKB, MINT, and/or STRING (see all 42 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF2Q9HAW01EBI-286668, EBI-1055224
    C20orf24Q9BUV81EBI-286668, EBI-1050079
    PTP4A3O753651EBI-286668, EBI-1043866
    IKBKGQ9Y6K92MINT-48232
    MAPK9P459842MINT-64910
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000059 protein import into nucleus, docking IEA--
    GO:0006611 protein export from nucleus IDA11024021
    GO:0051028 mRNA transport IEA--
    GO:0065002 intracellular protein transmembrane transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XPO7

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XPO7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XPO7)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_015024

                  Sigma-Aldrich siRNA for XPO7  
                         Sigma-Aldrich shRNA for XPO7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001100161  NM_001100162  NM_015024  

    REFSEQ mRNAs for XPO7 gene (3 alternative transcripts): 

    NM_001100161.1   NM_001100162.1   NM_015024.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001100161  NM_001100162  NM_015024  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001100161
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001100161
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001100161 

    Additional cDNA sequence: 

    AB018288.1 AF064729.1 AK291472.1 AK299848.1 AK311616.1 BC014219.2 BC030785.1 

    16 DOTS entries:

    DT.97780897  DT.95310524  DT.92439446  DT.75106176  DT.100641107  DT.95300785  DT.100706600  DT.95310531 
    DT.92017852  DT.92439443  DT.100781425  DT.104689  DT.121489919  DT.121489934  DT.121489938  DT.92439455 

    24/405 AceView cDNA sequences (see all 405 ):

    N79026 AA701943 BQ010451 C01267 AW130435 AW131378 H54683 AA232733 
    BM465733 BM786671 W19680 AA761468 BE275239 AI205301 R93525 F10605 
    N90414 BC014219 AA282083 BM561817 AA236543 AA235389 AA883234 AL044691 

    highest scoring ESTs for XPO7:

    AA091303 AA203698 AA410681 AA448490 AB018288 AF064729 AI024188 AI431948 AL044691 AL563597 

    Unigene Cluster for XPO7:

    Exportin 7
    Hs.172685  [show with all ESTs]
    Unigene Representative Sequence: NM_001100161


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000252512  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XPO7 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XPO7

    1 / 2 / 3

    5 probe-sets matching XPO7 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    40824_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB018288 0.80 1.00 0.91 1

    208459_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_015024 0.60 1.00 0.82 1

    212166_at2, 3 U133-A 1 1.00 1.00 -- -- H38643 0.20 1.00 0.72 1

    208459_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    212166_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.172685

    Expression variation in blood from EXPOLDB for XPO7

    UniProtKB/Swiss-Prot: XPO7_HUMAN, Q9UIA9
    Tissue specificity: Strong expression in testis, thyroid and bone marrow, low expression in lung,
    liver and small intestine, no expression in thymus, and remaining tissues studied have moderate
    expression

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for XPO7 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    XPO71   -- exportin 7 95.01(n)
    99.91(a)
    477387  XM_844516.1  XP_849609.1 
    chimpanzee
    (Pan troglodytes)
    XPO71   -- exportin 7 99.82(n)
    100(a)
    464037  XM_001151243.1  XP_001151243.1 
    rat
    (Rattus norvegicus)
    Xpo71   -- exportin 7 92.12(n)
    99.36(a)
    361070  XM_341353.3  XP_341354.2 
    mouse
    (Mus musculus)
    Xpo71, 5 145
    exportin 71, 5 91.78(n)1
    99.45(a)1
    652461  NM_023045.21  NP_075532.11 
     AI4294755  AJ2973605  (see all 28)
    chicken
    (Gallus gallus)
    XPO71   -- exportin 7 84.76(n)
    98.9(a)
    426925  NM_001012942.1  NP_001012960.1 
    About this table        Species with no ortholog for XPO7

    ENSEMBL Gene Tree for XPO7
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for XPO7 gene
    RANBP172  XPO42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/441 NCBI SNPs in XPO7 are shown (see all 441 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 168)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs72201,2
    A,C,F,H,O21919236(+) ACCGTA/GTAGAT 3 -- ut3110Minor allele frequency- G:0.47MN EA NA EU WA 2422
    rs70096931,2
    A,C,F,H21831260(+) gcagcA/Gtccag 2 -- ng518Minor allele frequency- G:0.46EU EA WA 836
    rs38243381,2
    A,C,F,H21920486(-) TCCTCG/TTTTGA 3 -- ng3110Minor allele frequency- T:0.46EA NA EU WA 2242
    rs69835061,2
    A,C,F,H21878576(+) GTTACC/GTATTT 3 -- ng51 int18Minor allele frequency- G:0.02EU EA WA 838
    rs78347291,2
    A,C,F,H21877724(+) AATAAG/TAACTG 3 -- int1 ng514Minor allele frequency- T:0.21EU EA WA 420
    rs151681,2
    F21919870(+) TTTTTA/TTTTCT 3 -- ut311Minor allele frequency- T:0.02MN 184
    rs46362041,2
    A21879152(+) AAATAG/TGAATC 3 -- int1 ng510--------
    --
    rs178568951,2
    H21912623(+) CATCTG/ACTTCT 3 Y/C mis1 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs29575301,2
    H21920402(+) GAGTTT/CCATTC 3 -- ng314Minor allele frequency- C:0.00EU EA WA 420
    rs29575291,2
    H21920236(+) CTCTGT/ACAACA 3 -- ng314Minor allele frequency- A:0.00EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for XPO7 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606140

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/11 PubMed articles for XPO7 gene (see all 11 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 23039 HGNC: 14108 AceView: XPO7 Ensembl:ENSG00000130227 euGenes: HUgn23039
    ECgene: XPO7 H-InvDB: XPO7
    (According to HUGE)
    About This Section

    HUGE: KIAA0745
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XPO7:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XPO7-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
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     Predesigned and custom siRNAs for XPO7 Antibodies for XPO7
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for XPO7 Browse small molecules at Sigma-Aldrich
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     Antibodies for XPO7

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