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XPO6 Gene

protein-coding   GIFtS: 57
GCID: GC16M028109

Exportin 6

(Previous name: RAN binding protein 20)
(Previous symbol: RANBP20)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exportin 61 2     KIAA03703 5
RANBP201 2 3     RAN Binding Protein 201
Ran-Binding Protein 202 3     exportin-62
EXP62 5     Exp63

External Ids:    HGNC: 197331   Entrez Gene: 232142   Ensembl: ENSG000001691807   OMIM: 6084115   UniProtKB: Q96QU83   

Export aliases for XPO6 gene to outside databases

Previous GC identifers: GC16M028207 GC16M028031 GC16M028075 GC16M028016 GC16M026200


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XPO6 Gene:
The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by
the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate
nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome
14. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
(provided by RefSeq, Aug 2012)

GeneCards Summary for XPO6 Gene:
XPO6 (exportin 6) is a protein-coding gene. Diseases associated with XPO6 include prostate cancer, and prostatitis. GO annotations related to this gene include protein transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8
Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells

Gene Wiki entry for XPO6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the XPO6 gene promoter:
         ER-alpha   STAT1   STAT1beta   LCR-F1   STAT1alpha   Roaz   COMP1   ZID   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPO6 promoter sequence
   Search Chromatin IP Primers for XPO6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XPO6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

XPO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028109:  view genomic region     (about GC identifiers)

Start:
28,109,300 bp from pter      End:
28,223,241 bp from pter
Size:
113,942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8 (See protein sequence)
Recommended Name: Exportin-6  
Size: 1125 amino acids; 128883 Da
Subunit: Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a
RanGTP-dependent manner
Sequence caution: Sequence=BAA20825.3; Type=Erroneous initiation;
Secondary accessions: A1L3W4 Q2YDX3 Q53G88 Q68G50 Q76N88 Q96CP8 Q9BT21

Explore the universe of human proteins at neXtProt for XPO6: NX_Q96QU8

Explore proteomics data for XPO6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys288
  • Modification sites at PhosphoSitePlus

  • See XPO6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257869.1  NP_055986.1  

    ENSEMBL proteins: 
     ENSP00000457341   ENSP00000456422   ENSP00000302790   ENSP00000454586   ENSP00000458314  
     ENSP00000455310   ENSP00000459591   ENSP00000459736   ENSP00000456066   ENSP00000457742  
     ENSP00000456273  

    XPO6 Human Recombinant Protein Products:

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    Novus Biologicals XPO6 Protein
    Novus Biologicals XPO6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XPO6

    XPO6 Antibody Products:

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    XPO6 Assay Products:

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    Cloud-Clone Corp. ELISAs for XPO6
    Cloud-Clone Corp. CLIAs for XPO6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    XPO: Exportins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q96QU8

    ProtoNet protein and cluster: Q96QU8

    1 Blocks protein domain: IPB013598 Exportin 1-like

    UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8
    Similarity: Belongs to the exportin family
    Similarity: Contains 1 importin N-terminal domain


    XPO6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPO6_HUMAN, Q96QU8
    Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI14592989
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity IDA14592989
         
    XPO6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for XPO6:
     Increased gamma-H2AX phosphory  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XPO6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for XPO6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XPO6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XPO6

    miRNA
    Products:
        
    miRTarBase miRNAs that target XPO6:
    hsa-mir-320a (MIRT044849), hsa-mir-122-5p (MIRT003106), hsa-mir-1 (MIRT002751), hsa-mir-16-5p (MIRT051247), hsa-mir-185-5p (MIRT045379), hsa-mir-222-3p (MIRT046690), hsa-mir-181b-5p (MIRT047267), hsa-mir-324-5p (MIRT043121)

    Block miRNA regulation of human, mouse, rat XPO6 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate XPO6:
    hsa-miR-3673 hsa-miR-206 hsa-miR-539 hsa-miR-216b hsa-miR-1 hsa-miR-570 hsa-miR-613 hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidXPO6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for XPO6
    Predesigned siRNA for gene silencing in human, mouse, rat XPO6

    Gene Editing
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    OriGene clones in human, mouse for XPO6 (see all 7)
    OriGene ORF clones in mouse, rat for XPO6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: XPO6 (NM_015171)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for XPO6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XPO6_HUMAN, Q96QU8: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol3
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    XPO6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XPO6
    Interactions:

        Search GeneGlobe Interaction Network for XPO6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for XPO6 (Q96QU82, 3 ENSP000003027904) via UniProtKB, MINT, STRING, and/or I2D (see all 633)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-7945693 I2D: score=2 STRING: ENSP00000349960
    DIAPH1O606102, 3, ENSP000003815654MINT-7945693 I2D: score=2 STRING: ENSP00000381565
    ENAHQ8N8S72, 3, ENSP000003558094MINT-7945693 I2D: score=1 STRING: ENSP00000355809
    VASPP505522, 3, ENSP000002459324MINT-7945693 I2D: score=3 STRING: ENSP00000245932
    NUP62P371982, 3, ENSP000003055034MINT-66588 I2D: score=6 STRING: ENSP00000305503
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006611protein export from nucleus IDA14592989
    GO:0006886intracellular protein transport ----

    XPO6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XPO6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for XPO6 gene (2 alternative transcripts): 
    NM_001270940.1  NM_015171.3  

    Unigene Cluster for XPO6:

    Exportin 6
    Hs.460468  [show with all ESTs]
    Unigene Representative Sequence: NM_001270940
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000565698 ENST00000568065 ENST00000304658(uc002dpa.1 uc002dpb.1 uc010vcp.1)
    ENST00000569315 ENST00000567038 ENST00000570007 ENST00000573275 ENST00000569216
    ENST00000564905 ENST00000562408 ENST00000563138 ENST00000565284 ENST00000567842
    ENST00000564337 ENST00000570294 ENST00000566175 ENST00000574435 ENST00000561488

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat XPO6 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate XPO6:
    hsa-miR-3673 hsa-miR-206 hsa-miR-539 hsa-miR-216b hsa-miR-1 hsa-miR-570 hsa-miR-613 hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidXPO6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for XPO6
    Predesigned siRNA for gene silencing in human, mouse, rat XPO6
    Clone
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    OriGene clones in human, mouse for XPO6 (see all 7)
    OriGene ORF clones in mouse, rat for XPO6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: XPO6 (NM_015171)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for XPO6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XPO6
      QuantiTect SYBR Green Assays in human, mouse, rat XPO6
      QuantiFast Probe-based Assays in human, mouse, rat XPO6

    Additional mRNA sequence: 

    AB002368.3 AK026172.1 AK123846.1 AK223043.1 AY026388.1 BC004403.1 BC014071.2 BC078674.1 
    BC108286.1 BC130304.1 BC144189.1 

    Selected DOTS entries (see all 27):

    DT.86859944  DT.101957099  DT.99962948  DT.97766368  DT.100892148  DT.40115087  DT.95256299  DT.120725170 
    DT.91775695  DT.100829083  DT.100892115  DT.120725236  DT.91775699  DT.97779291  DT.100834878  DT.100892163 
    DT.120725157  DT.120725174  DT.120725191  DT.120725250  DT.120725270  DT.92059594  DT.95086476  DT.95163788 

    Selected AceView cDNA sequences (see all 559):

    BF929698 BI258899 BE795317 BC014071 BE674819 BQ632511 BX386658 CB156234 
    BE265209 BM552554 AI499039 BQ064948 BU151098 BM830190 BU164216 BX505092 
    AI523250 BE384383 BQ671515 BU501265 BU680980 BE262032 BC004403 BC078674 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for XPO6 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                    -                       -                                         -     -     -                                                         
    SP2:              -     -                       -                                         -     -     -                                                         
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b · 28c · 28d · 28e
    SP1:                                                  -                       -                                 
    SP2:                                                  -                       -                                 
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                  -                                                         


    ECgene alternative splicing isoforms for XPO6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XPO6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGAATT
    XPO6 Expression
    About this image


    XPO6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Testis (Reproductive System)
     
     Umbilical Cord (Extraembryonic Tissues)
     
     Spleen (Hematopoietic System)
    XPO6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XPO6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.460468
        Custom PCR Arrays for XPO6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for XPO6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XPO6
    QuantiTect SYBR Green Assays in human, mouse, rat XPO6
    QuantiFast Probe-based Assays in human, mouse, rat XPO6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for XPO6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpo61 , 5 exportin 61, 5 91.01(n)1
    97.86(a)1
      7 (69.01 cM)5
    742041  NM_028816.21  NP_083092.21 
     1261017155 
    chicken
    (Gallus gallus)
    Aves XPO61 exportin 6 84(n)
    93.86(a)
      416410  XM_414725.4  XP_414725.3 
    lizard
    (Anolis carolinensis)
    Reptilia XPO66
    exportin 6
    81(a)
    1 ↔ 1
    GL343518.1(36822-89032)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.72982 Xenopus laevis transcribed sequence with weak similarity to protein refNP_524879.1 (D.melanogaster) lethal (1) 1Bb [Drosophila melanogaster] less 76.53(n)    CA974586.1 
    zebrafish
    (Danio rerio)
    Actinopterygii xpo62 exportin 6 75.26(n)   333980  BC044132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Exp66
    Exportin 6
    25(a)
    1 ↔ 1
    X(365085-370625)


    ENSEMBL Gene Tree for XPO6 (if available)
    TreeFam Gene Tree for XPO6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for XPO6 gene

    XPO6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for XPO6
    PGOHUM00000262206


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for XPO6 (see all 2239)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs568303091,2
    C--26294539(+) AAAAA-/A/AAA 
            
    GTTAT
    2 -- int11NA 2
    rs1404272791,2
    C--28108958(+) CCACAA/GGGGCC 2 -- ds50010--------
    rs610821431,2
    C,F--28109053(+) ACCAGT/CACCAG 2 -- ds50014Minor allele frequency- C:0.17WA CSA EA 242
    rs1174508031,2
    F--28109132(+) ACCCCC/TTCCCC 2 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1426880691,2
    --28109139(+) CCCCTC/TGCTGA 2 -- ds50010--------
    rs1473623471,2
    --28109184(+) GGAGAC/TGCCAG 2 -- ds50010--------
    rs1164426891,2
    C,F--28109260(+) CCTCAA/GGGAGG 2 -- ds50012Minor allele frequency- G:0.02WA NA 238
    rs1850223791,2
    --28109322(+) GCATTC/TTATTT 2 -- ut310--------
    rs1397642801,2
    --28109390(+) AAAACA/GTGAGT 2 -- ut310--------
    rs1897757951,2
    --28109440(+) ATTGGC/GGCGGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for XPO6 (28109300 - 28223241 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for XPO6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656622CNV Deletion23128226
    nsv507812CNV Insertion20534489
    nsv469663CNV Loss16826518
    nsv103104CNV Loss16902084
    nsv9409CNV Gain18304495
    nsv9410CNV Gain18304495
    nsv525423CNV Gain19592680
    nsv9408CNV Gain18304495
    dgv842e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608411    OMIM disorders: --

    3 diseases for XPO6:    
    About MalaCards
    prostate cancer    prostatitis    leukemia


    XPO6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): XPO6
    Human Genome Epidemiology (HuGE) Navigator: XPO6 (1 document)

    Export disorders for XPO6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XPO6 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with XPO6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. (PubMed id 14592989)1, 2, 3, 9 Stueven T.... Goerlich D. (EMBO J. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    6. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. (PubMed id 18676839)1, 9 Ambs S....Croce C.M. (Cancer Res. 2008)
    7. Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. (PubMed id 18614847)1, 9 Suzuki T....Isemura M. (Biomed. Res. 2008)
    8. DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. (PubMed id 16847355)1, 9 Suzuki T....Isemura M. (Biomed. Res. 2006)
    9. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23214 HGNC: 19733 AceView: XPO6 Ensembl:ENSG00000169180 euGenes: HUgn23214
    ECgene: XPO6 H-InvDB: XPO6

    (According to HUGE)
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    HUGE: KIAA0370

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for XPO6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for XPO6 gene:
    Search GeneIP for patents involving XPO6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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