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Aliases & Descriptions for XPO6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EXP6 2, 5 | | Exp6 3 | | FLJ22519 1, 2 | | KIAA0370 1, 2, 3, 5 | | RANBP20 2, 3 |
| | | Descriptions |
|---|
| RAN binding protein 20 1, 2 | | Ran-binding protein 20 3 | | exportin 6 2 |
|
| | Search outside databases for aliases for XPO6 genePrevious GC identifers: GC16M028207 GC16M028031 GC16M028075 |
Summaries for XPO6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for XPO6: Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of RAN (MIM 601179)-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.[supplied by OMIM] UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cellsGene Wiki entry for XPO6 |
Genomic Location for XPO6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the XPO6 gene 
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2XPO6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M028016:
(about GC identifiers)
Start:
|
28,016,817 bp from pter |
End:
|
28,130,691 bp from pter |
Size:
|
113,875 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010393.15
| Proteins for XPO6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8 (See
protein sequence)Recommended Name: Exportin-6 Size: 1125 amino acids; 128883 Da
Subunit: Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
Secondary accessions: Q2YDX3 Q53G88 Q68G50 Q76N88 Q96CP8 Q9BT21Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055986.1
ENSEMBL proteins: ENSP00000302790
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for XPO6: Assays for XPO6: | Protein
Domains/ Families for XPO6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96QU8
ProtoNet protein and cluster: Q96QU8 1 Blocks protein family: IPB013598 Exportin 1-like
UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8Similarity: Belongs to the exportin familySimilarity: Contains 1 importin N-terminal domain | Gene Function for XPO6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015171
Applied Biosystems Silencer® siRNAs for XPO6
Sigma-Aldrich siRNA for XPO6  Sigma-Aldrich shRNA for XPO6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015171                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015171                                  untagged cDNA clones in CMV expression vector (see all 2): NM_015171 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015171
UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for XPO6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for XPO6 (Q96QU81, 2 ENSP000003027903) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000059 | protein import into nucleus, docking |
IEA | -- | | GO:0006611 | protein export from nucleus |
IDA | 14592989 | | GO:0006886 | intracellular protein transport |
IEA | -- | About this table
|
Drugs & Compounds for XPO6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for XPO6
|
Transcripts for XPO6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015171
Sigma-Aldrich siRNA for XPO6  Sigma-Aldrich shRNA for XPO6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015171 REFSEQ mRNAs for XPO6 gene: NM_015171.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015171               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015171                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015171                                  untagged cDNA clones in CMV expression vector (see all 2): NM_015171  Additional cDNA sequence: AB002368.3 AK026172.1 AK123846.1 AK223043.1 AY026388.1 BC004403.1 BC014071.2 BC078674.1 BC108286.1 BC130304.1 BC144189.1 CR601489.1 CR618868.1 CR626761.1 24/27 DOTS entries (see all 27
): DT.86859944 DT.101957099 DT.99962948 DT.97766368 DT.100892148 DT.40115087 DT.95256299 DT.120725157 DT.120725170 DT.91775695 DT.100829083 DT.100892115 DT.120725236 DT.91775699 DT.97779291 DT.100834878 DT.100892163 DT.120725174 DT.120725191 DT.120725250 DT.120725270 DT.92059594 DT.95086476 DT.95163788 24/559 AceView cDNA sequences (see all 559
):BM828332 AV659602 BQ065612 BQ066084 BQ069898 AI651251 BC004403 BM505347 BM453784 BE887989 BU733132 BU164216 AA406606 AW468178 BP872070 BQ064271 BX505092 BE265209 BQ647500 AI189518 BQ000534 BG743169 AI189326 BF924445
highest scoring ESTs for XPO6:AB002368 AK123846 AY026388 AA026169 AA027230 AA044962 AA046211 AA113933 AA114000 AA126434 Unigene Cluster for XPO6: Exportin 6 Hs.460468 [show with all ESTs]Unigene Representative Sequence: NM_015171
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for XPO6 (see all 13
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27a | · | 27b | ^ | 28a | · | 28b | · | 28c | · | 28d | · | 28e | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for XPO6
1 Ensembl transcript including schematic representation: ENST00000304658
|
Expression for XPO6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| XPO6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for XPO6
1 / 2 / 3 5 probe-sets matching XPO6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGCAGAATT
SOURCE GeneReport for Unigene cluster: Hs.460468
Expression variation in blood from EXPOLDB for XPO6 |
Orthologs for XPO6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XPO6 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for XPO6
ENSEMBL Gene Tree for XPO6 | Paralogs for XPO6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for XPO6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for XPO6 (up to first 250kb)
|
Disorders & Mutations for XPO6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608411
|
Medical News for XPO6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for XPO6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for XPO6 gene (see all 16
):- Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. (PubMed id 14592989)1, 2, 3, 4 Stueven T.... Goerlich D. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)3, 4 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)3, 4 Nagase T....Ohara O. (1997)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
|
Search for XPO6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing XPO6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing XPO6
(According to HUGE)
About This Section
| |
Specialized Databases showing XPO6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for XPO6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for XPO6:

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| | Recombinant Proteins (XPO6) | | Antibodies (XPO6) |
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Incremental update: 13 Oct 2009
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