Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

XPO6 Gene

protein-coding GIFtS: 54
GCID: GC16M028109

exportin 6

(Previous name: RAN binding protein 20 )
(Previous symbol: RANBP20)

Explore 3 diseases affiliated with
XPO6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Exportin 6¹ ²		FLJ22519¹
RANBP20¹ ² ³		RAN Binding Protein 20¹
KIAA0370¹ ³ ⁵		Exportin-6¹
Ran-Binding Protein 20² ³		Exp6³
EXP6² ⁵

External Ids:	HGNC: 19733¹	Entrez Gene: 23214²	Ensembl: ENSG00000169180⁷	OMIM: 608411⁵	UniProtKB: Q96QU8³

Export aliases for XPO6 gene to outside databases

Previous GC identifers: GC16M028207 GC16M028031 GC16M028075 GC16M028016 GC16M026200

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XPO6:

The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the

GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear

export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative

splicing results in multiple transcript variants that encode different protein isoforms. (provided by RefSeq, Aug

2012)

UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8

Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells

Gene Wiki entry for XPO6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the XPO6 gene promoter:
ER-alpha STAT1 STAT1beta LCR-F1 STAT1alpha Roaz COMP1 ZID NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XPO6 promoter sequence

Search SABiosciences Chromatin IP Primers for XPO6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPO6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

XPO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO6 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M028109: view genomic region (about GC identifiers)

Start:	28,109,300 bp from pter	End:	28,223,241 bp from pter
Size:	113,942 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8 (See protein sequence)

Recommended Name: Exportin-6

Size: 1125 amino acids; 128883 Da

Subunit: Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a

RanGTP-dependent manner

Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm

Sequence caution: Sequence=BAA20825.3; Type=Erroneous initiation;

Secondary accessions: A1L3W4 Q2YDX3 Q53G88 Q68G50 Q76N88 Q96CP8 Q9BT21

Explore the universe of human proteins at neXtProt for XPO6: NX_Q96QU8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96QU8

XPO6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001257869.1 NP_055986.1

ENSEMBL proteins:

ENSP00000457341 ENSP00000456422 ENSP00000302790 ENSP00000454586 ENSP00000458314

ENSP00000455310 ENSP00000459591 ENSP00000459736 ENSP00000456066 ENSP00000457742

ENSP00000456273

Human Recombinant Protein Products for XPO6:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: XPO6 OriGene Protein Over-expression Lysate: XPO6 OriGene Custom Protein Services for XPO6
	GenScript Custom Purified and Recombinant Proteins Services for XPO6
	Novus Biologicals XPO6 Protein Novus Biologicals XPO6 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for XPO6

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005643	nuclear pore	IEA	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

XPO6 for ontologies About GeneDecksing

XPO6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for XPO6
	GenScript Custom Superior Antibodies Services for XPO6
	Novus Biologicals XPO6 Antibodies
	Abcam antibodies for XPO6
	Uscn Antibodies for XPO6
	ThermoFisher Antibodies for XPO6

Assay Products for XPO6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for XPO6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for XPO6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

XPO6 for domains About GeneDecksing

4 InterPro domains/families:

IPR011989 ARM-like

IPR013598 Exportin-1/Importin-b-like

IPR001494 Importin-beta_N

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q96QU8

ProtoNet protein and cluster: Q96QU8

1 Blocks protein family: IPB013598 Exportin 1-like

UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8

Similarity: Belongs to the exportin family

Similarity: Contains 1 importin N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: XPO6_HUMAN, Q96QU8

Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14592989
GO:0008565	protein transporter activity	IDA	14592989

XPO6 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for XPO6:

Increased gamma-H2AX phosphory

Wnt reporter downregulated

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for XPO6

miRNA Products:		miRTarBase miRNAs that target XPO6: hsa-mir-122 (MIRT003106), hsa-mir-1 (MIRT002751)

		OriGene 3'-UTR Clone: XPO6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XPO6
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate XPO6:
		hsa-miR-3673 hsa-miR-206 hsa-miR-539 hsa-miR-216b hsa-miR-1 hsa-miR-570 hsa-miR-613 hsa-miR-1272

		SwitchGear 3'UTR luciferase reporter plasmid: XPO6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XPO6 (see all 7) OriGene shRNA RFP: XPO6 OriGene siRNA: XPO6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XPO6
		Sirion Biotech Custom design and validation of potent shRNA sequences against XPO6

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for XPO6
			Sirion Biotech Customized adenovirus for overexpression of XPO6 Sirion Biotech Customized adenovirus for potent knockdown of XPO6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XPO6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XPO6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: XPO6 (NM_015171)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XPO6
		Search LifeMap BioReagents cell lines for XPO6
		Sirion Biotech Customized stable knockdown cell line services for XPO6 Sirion Biotech Customized inducible knockdown cell line services for XPO6 Sirion Biotech Customized stable overexpressing cell line services for XPO6 Sirion Biotech Customized inducible overexpressing cell line services for XPO6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for XPO6

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/564 Interacting proteins for XPO6 (Q96QU8^{2, 3} ENSP00000302790⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 564)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709²^,³, ENSP00000349960⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000349960
DIAPH1	O60610²^,³, ENSP00000381565⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000381565
ENAH	Q8N8S7²^,³, ENSP00000355809⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000355809
VASP	P50552²^,³, ENSP00000245932⁴	MINT-7945693 I2D: score=3 STRING: ENSP00000245932
NUP62	P37198²^,³, ENSP00000305503⁴	MINT-66588 I2D: score=6 STRING: ENSP00000305503

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006611	protein export from nucleus	IDA	14592989
GO:0006886	intracellular protein transport	--	--

XPO6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for XPO6
Search CenterWatch for drugs/clinical trials and news about XPO6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for XPO6 gene (2 alternative transcripts):

NM_001270940.1 NM_015171.3

Unigene Cluster for XPO6:

Exportin 6

Hs.460468 [show with all ESTs]

Unigene Representative Sequence: NM_001270940

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000565698 ENST00000568065 ENST00000304658(uc002dpa.1 uc002dpb.1 uc010vcp.1)

ENST00000569315 ENST00000567038 ENST00000570007 ENST00000573275 ENST00000569216

ENST00000564905 ENST00000562408 ENST00000563138 ENST00000565284 ENST00000567842

ENST00000564337 ENST00000570294 ENST00000566175 ENST00000574435 ENST00000561488

miRNA Products:		OriGene 3'-UTR Clone: XPO6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XPO6
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate XPO6:
		hsa-miR-3673 hsa-miR-206 hsa-miR-539 hsa-miR-216b hsa-miR-1 hsa-miR-570 hsa-miR-613 hsa-miR-1272

		SwitchGear 3'UTR luciferase reporter plasmid: XPO6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XPO6 (see all 7) OriGene shRNA RFP: XPO6 OriGene siRNA: XPO6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XPO6
		Sirion Biotech Custom design and validation of potent shRNA sequences against XPO6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XPO6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XPO6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: XPO6 (NM_015171)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XPO6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat XPO6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPO6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPO6

Additional cDNA sequence:

AB002368.3 AK026172.1 AK123846.1 AK223043.1 AY026388.1 BC004403.1 BC014071.2 BC078674.1

BC108286.1 BC130304.1 BC144189.1

24/27 DOTS entries (see all 27):

DT.86859944 DT.101957099 DT.99962948 DT.97766368 DT.100892148 DT.40115087 DT.95256299 DT.120725170

DT.91775695 DT.100829083 DT.100892115 DT.120725236 DT.91775699 DT.97779291 DT.100834878 DT.100892163

DT.120725157 DT.120725174 DT.120725191 DT.120725250 DT.120725270 DT.92059594 DT.95086476 DT.95163788

24/559 AceView cDNA sequences (see all 559):

BI910581 CR626761 BU557033 BM699736 H44524 BQ065612 CA428128 AW879928

BQ009800 AW470645 BE899008 BX386658 BE795814 BU195961 BM828332 BE674819

CA867784 BU626644 BE795590 BU194924 BU540989 BM742212 BU175958 AA676861

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for XPO6 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^
SP1:							-								-														-		-		-
SP2:					-		-								-														-		-		-
SP3:																																																			-
SP4:
SP5:

ExUns:	20	^	21	^	22a	·	22b	^	23	^	24a	·	24b	^	25	^	26a	·	26b	·	26c	^	27a	·	27b	^	28a	·	28b	·	28c	·	28d	·	28e
SP1:																	-								-
SP2:																	-								-
SP3:
SP4:
SP5:																	-

ECgene alternative splicing isoforms for XPO6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

XPO6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCAGAATT

About this image
See XPO6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XPO6

SOURCE GeneReport for Unigene cluster: Hs.460468
SABiosciences Custom PCR Arrays for XPO6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XPO6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat XPO6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPO6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPO6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for XPO6 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Xpo6^{1 , 5}	exportin 6^{1, 5}	91.07(n)¹ 97.95(a)¹		7 (69.01 cM)⁵ 74204¹ NM_028816.2¹ NP_083092.2¹ 126101715⁵
chicken (Gallus gallus)	Aves	XPO6¹	exportin 6	84(n) 93.86(a)		416410 XM_414725.3 XP_414725.3
lizard (Anolis carolinensis)	Reptilia	XPO6⁶	--	81(a)	1 ↔ 1	GL343518.1(36822-82484)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7298²	Xenopus laevis transcribed sequence with weak similarity more	76.53(n)		CA974586.1
zebrafish (Danio rerio)	Actinopterygii	xpo6²	exportin 6	75.26(n)		333980 BC044132.1
fruit fly (Drosophila melanogaster)	Insecta	Exp6⁶	Exportin 6	23(a)	1 ↔ 1	X(365085-370625)

ENSEMBL Gene Tree for XPO6 (if available)
TreeFam Gene Tree for XPO6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for XPO6 gene

XPO6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for XPO6
PGOHUM00000262206

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140427279^1,2		--	28108958(+)	`CCACAA/GGGGCC`	2	--	ds500¹		0	--	--	--	--
rs61082143^1,2	C,F	--	28109053(+)	`ACCAGT/CACCAG`	2	--	ds500¹		4		WA CSA EA	242
rs117450803^1,2		--	28109132(+)	`ACCCCC/TTCCCC`	2	--	ds500¹		1		EA	120
rs142688069^1,2		--	28109139(+)	`CCCCTC/TGCTGA`	2	--	ds500¹		0	--	--	--	--
rs147362347^1,2		--	28109184(+)	`GGAGAC/TGCCAG`	2	--	ds500¹		0	--	--	--	--
rs116442689^1,2	F	--	28109260(+)	`CCTCAA/GGGAGG`	2	--	ds500¹		2		WA NA	238
rs185022379^1,2		--	28109322(+)	`GCATTC/TTATTT`	2	--	ut3¹		0	--	--	--	--
rs139764280^1,2		--	28109390(+)	`AAAACA/GTGAGT`	2	--	ut3¹		0	--	--	--	--
rs189775795^1,2		--	28109440(+)	`ATTGGC/GGCGGG`	2	--	ut3¹		0	--	--	--	--
rs79537335^1,2	C,F	--	28109443(+)	`GGGGCG/AGGGGA`	2	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for XPO6 (28109300 - 28223241 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for XPO6
4 CNVs: 30766 2208 5818 3999
2 Indels: 33299 33300

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XPO6

DNA2.0 Custom Variant and Variant Library Synthesis for XPO6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

XPO6 for disorders           About GeneDecksing

OMIM gene information: 608411    OMIM disorders: --

3 diseases for XPO6:    About MalaCards

prostate cancer prostatitis leukemia

Human Genome Epidemiology (HuGE) Navigator: XPO6 (1 document)

Export disorders for XPO6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for XPO6 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with XPO6)

Utopia: connect your pdf to the dynamic
world of online information

Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. (PubMed id 14592989)^{1, 2, 3, 9} Stueven T.... Goerlich D. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2} Nagase T.... Ohara O. (1997)
Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. (PubMed id 18676839)^{1, 9} Ambs S....Croce C.M. (2008)
Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. (PubMed id 18614847)^{1, 9} Suzuki T....Isemura M. (2008)
DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. (PubMed id 16847355)^{1, 9} Suzuki T....Isemura M. (2006)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Active maintenance of nuclear actin by importin 9 supp orts transcription. (PubMed id 22323606)¹ Dopie J....Vartiainen M.K. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23214	HGNC: 19733	AceView: XPO6	Ensembl:ENSG00000169180	euGenes: HUgn23214
ECgene: XPO6	H-InvDB: XPO6

(According to HUGE)
About This Section

HUGE: KIAA0370

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for XPO6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for XPO6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for XPO6 gene:
Search GeneIP for patents involving XPO6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for XPO6
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XPO6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XPO6
	OriGene Protein Over-expression Lysate for XPO6		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for XPO6		OriGene 3'-UTR Clone for XPO6
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XPO6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XPO6
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for XPO6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for XPO6		OriGene Custom Protein Services for XPO6
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XPO6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XPO6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPO6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XPO6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPO6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPO6

	GenScript Custom Purified and Recombinant Proteins Services for XPO6		GenScript cDNA clones with any tag delivered in your preferred vector for XPO6
	GenScript Custom Assay Services for XPO6		GenScript Custom Superior Antibodies Services for XPO6
	GenScript Custom overexpressing Cell Line Services for XPO6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in XPO6 promoter
	Search Chromatin IP Primers for XPO6
	RT² qPCR Primer Assay in human, mouse, rat XPO6
	Search GNC Networks for XPO6
	SABiosciences Custom PCR Arrays for XPO6

Search Tocris compounds for XPO6

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	XPO6 antibodies
	XPO6 proteins
	XPO6 lysates

	Antibodies for XPO6
	See all of Abcam's Antibodies, Kits and Proteins for XPO6
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

XPO6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for XPO6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO6

	SwitchGear 3'UTR luciferase reporter plasmids for XPO6
	SwitchGear Promoter luciferase reporter plasmids for XPO6

ThermoFisher Antibodies for XPO6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO6

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for XPO6

Sirion Biotech Customized:

	stable knockdown cell line services for XPO6
	inducible knockdown cell line services for XPO6
	design and validation of potent shRNA sequences against XPO6
	adenovirus for potent knockdown of XPO6
	adenovirus for overexpression of XPO6
	stable overexpressing cell line services for XPO6
	inducible overexpressing cell line services for XPO6

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes XPO6 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

XPO6 Gene

exportin 6

Aliases
for XPO6 gene

Summaries
for XPO6 gene

Genomic Views
for XPO6 gene

Proteins
for XPO6 gene

Protein Domains /
Families
for XPO6 gene

Function
for XPO6 gene

Pathways & Interactions
for XPO6 gene

Drugs & Compounds
for XPO6 gene

Transcripts
for XPO6 gene

Expression
for XPO6 gene

Orthologs
for XPO6 gene

Paralogs
for XPO6 gene

Genomic Variants
for XPO6 gene

Disorders / Diseases
for XPO6 gene

Publications
for XPO6 gene

External Searches for XPO6 gene

Genome Databases showing XPO6 gene

Other Databases showing XPO6 gene

Specialized Databases showing XPO6 gene

Intellectual Property
for XPO6 gene

Products
for XPO6 gene

View Random Gene

Advanced Search

Export list of displayed genes

XPO6 Gene

exportin 6

Aliasesfor XPO6 gene

Summariesfor XPO6 gene

Genomic Viewsfor XPO6 gene

Proteinsfor XPO6 gene

Protein Domains /Familiesfor XPO6 gene

Functionfor XPO6 gene

Pathways & Interactionsfor XPO6 gene

Drugs & Compoundsfor XPO6 gene

Transcriptsfor XPO6 gene

Expression for XPO6 gene

Orthologsfor XPO6 gene

Paralogsfor XPO6 gene

Genomic Variantsfor XPO6 gene

Disorders / Diseasesfor XPO6 gene

Publicationsfor XPO6 gene

External Searches for XPO6 gene

Genome Databases showing XPO6 gene

Other Databases showing XPO6 gene

Specialized Databases showing XPO6 gene

Intellectual Propertyfor XPO6 gene

Productsfor XPO6 gene

View Random Gene

Aliases
for XPO6 gene

Summaries
for XPO6 gene

Genomic Views
for XPO6 gene

Proteins
for XPO6 gene

Protein Domains /
Families
for XPO6 gene

Function
for XPO6 gene

Pathways & Interactions
for XPO6 gene

Drugs & Compounds
for XPO6 gene

Transcripts
for XPO6 gene

Expression
for XPO6 gene

Orthologs
for XPO6 gene

Paralogs
for XPO6 gene

Genomic Variants
for XPO6 gene

Disorders / Diseases
for XPO6 gene

Publications
for XPO6 gene

Intellectual Property
for XPO6 gene

Products
for XPO6 gene