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Aliases for XPO6 Gene

Aliases for XPO6 Gene

  • Exportin 6 2 3 5
  • Ran-Binding Protein 20 3 4
  • RANBP20 3 4
  • EXP6 3 4
  • RAN Binding Protein 20 2
  • KIAA0370 4

External Ids for XPO6 Gene

Previous HGNC Symbols for XPO6 Gene

  • RANBP20

Previous GeneCards Identifiers for XPO6 Gene

  • GC16M028207
  • GC16M028031
  • GC16M028075
  • GC16M028016
  • GC16M026200

Summaries for XPO6 Gene

Entrez Gene Summary for XPO6 Gene

  • The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for XPO6 Gene

XPO6 (Exportin 6) is a Protein Coding gene. GO annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot for XPO6 Gene

  • Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Gene Wiki entry for XPO6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO6 Gene

Genomics for XPO6 Gene

Regulatory Elements for XPO6 Gene

Promoters for XPO6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around XPO6 on UCSC Golden Path with GeneCards custom track

Genomic Location for XPO6 Gene

Chromosome:
16
Start:
28,097,976 bp from pter
End:
28,211,960 bp from pter
Size:
113,985 bases
Orientation:
Minus strand

Genomic View for XPO6 Gene

Genes around XPO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO6 Gene

Proteins for XPO6 Gene

  • Protein details for XPO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QU8-XPO6_HUMAN
    Recommended name:
    Exportin-6
    Protein Accession:
    Q96QU8
    Secondary Accessions:
    • A1L3W4
    • D3DWF9
    • Q2YDX3
    • Q53G88
    • Q68G50
    • Q76N88
    • Q96CP8
    • Q9BT21

    Protein attributes for XPO6 Gene

    Size:
    1125 amino acids
    Molecular mass:
    128883 Da
    Quaternary structure:
    • Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.
    SequenceCaution:
    • Sequence=BAA20825.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for XPO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XPO6 Gene

Proteomics data for XPO6 Gene at MOPED

Post-translational modifications for XPO6 Gene

  • Ubiquitination at Lys 288
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for XPO6 Gene

Domains & Families for XPO6 Gene

Gene Families for XPO6 Gene

Protein Domains for XPO6 Gene

Suggested Antigen Peptide Sequences for XPO6 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QU8

UniProtKB/Swiss-Prot:

XPO6_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the exportin family.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO6: view

Function for XPO6 Gene

Molecular function for XPO6 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Gene Ontology (GO) - Molecular Function for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with XPO6: view
genes like me logo Genes that share phenotypes with XPO6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for XPO6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO6 Gene

Localization for XPO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO6 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPO6 Gene COMPARTMENTS Subcellular localization image for XPO6 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with XPO6: view

Pathways & Interactions for XPO6 Gene

SuperPathways for XPO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for XPO6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for XPO6 Gene

Drugs & Compounds for XPO6 Gene

No Compound Related Data Available

Transcripts for XPO6 Gene

Unigene Clusters for XPO6 Gene

Exportin 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XPO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b · 28c · 28d · 28e
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:

Relevant External Links for XPO6 Gene

GeneLoc Exon Structure for
XPO6
ECgene alternative splicing isoforms for
XPO6

Expression for XPO6 Gene

mRNA expression in normal human tissues for XPO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XPO6 Gene

This gene is overexpressed in Whole Blood (x20.7).

Protein differential expression in normal tissues from HIPED for XPO6 Gene

This gene is overexpressed in Bone (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPO6 Gene



SOURCE GeneReport for Unigene cluster for XPO6 Gene Hs.460468

genes like me logo Genes that share expression patterns with XPO6: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for XPO6 Gene

Orthologs for XPO6 Gene

This gene was present in the common ancestor of animals.

Orthologs for XPO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO6 36
  • 100 (a)
OneToOne
XPO6 35
  • 99.7 (n)
  • 99.91 (a)
cow
(Bos Taurus)
Mammalia XPO6 36
  • 98 (a)
OneToOne
XPO6 35
  • 93.36 (n)
  • 98.04 (a)
dog
(Canis familiaris)
Mammalia XPO6 35
  • 94.01 (n)
  • 98.84 (a)
XPO6 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo6 16
Xpo6 35
  • 91.01 (n)
  • 97.86 (a)
Xpo6 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPO6 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Xpo6 35
  • 90.93 (n)
  • 97.6 (a)
chicken
(Gallus gallus)
Aves XPO6 35
  • 84 (n)
  • 93.86 (a)
XPO6 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPO6 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7298 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491765 35
  • 73.73 (n)
  • 80.94 (a)
Str.7195 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5198 35
zebrafish
(Danio rerio)
Actinopterygii xpo6 36
  • 72 (a)
OneToOne
xpo6 35
  • 69.41 (n)
  • 74.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Exp6 36
  • 25 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13929 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for XPO6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XPO6 Gene

ENSEMBL:
Gene Tree for XPO6 (if available)
TreeFam:
Gene Tree for XPO6 (if available)

Paralogs for XPO6 Gene

Pseudogenes.org Pseudogenes for XPO6 Gene

genes like me logo Genes that share paralogs with XPO6: view

No data available for Paralogs for XPO6 Gene

Variants for XPO6 Gene

Sequence variations from dbSNP and Humsavar for XPO6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs188192 -- 28,120,189(+) ATAAT(A/C)ATCAT intron-variant
rs39631 -- 28,125,927(+) GCAAG(A/C)CACAC intron-variant
rs41101 -- 28,124,414(+) ATGGA(C/T)TTATC intron-variant
rs245741 -- 28,120,777(+) TCTAC(A/G)GCAGG intron-variant
rs245740 -- 28,132,654(-) TTTTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPO6 Gene

Variant ID Type Subtype PubMed ID
nsv469663 CNV Loss 16826518
nsv9408 CNV Gain 18304495
esv2656622 CNV Deletion 23128226
nsv9409 CNV Gain 18304495
dgv842e1 CNV Complex 17122850
nsv507812 CNV Insertion 20534489
nsv103104 CNV Loss 16902084
nsv525423 CNV Gain 19592680
nsv9410 CNV Gain 18304495

Variation tolerance for XPO6 Gene

Residual Variation Intolerance Score: 7.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XPO6 Gene

HapMap Linkage Disequilibrium report
XPO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO6 Gene

Disorders for XPO6 Gene

Relevant External Links for XPO6

Genetic Association Database (GAD)
XPO6
Human Genome Epidemiology (HuGE) Navigator
XPO6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XPO6

No disorders were found for XPO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XPO6 Gene

Publications for XPO6 Gene

  1. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. (PMID: 14592989) Stueven T. … Goerlich D. (EMBO J. 2003) 2 3 4 23 67
  2. Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. (PMID: 18614847) Suzuki T. … Isemura M. (Biomed. Res. 2008) 3 23
  3. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. (PMID: 18676839) Ambs S. … Croce C.M. (Cancer Res. 2008) 3 23
  4. DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. (PMID: 16847355) Suzuki T. … Isemura M. (Biomed. Res. 2006) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for XPO6 Gene

Sources for XPO6 Gene

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