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Aliases for XPO6 Gene

Aliases for XPO6 Gene

  • Exportin 6 2 3
  • EXP6 3 4 6
  • Ran-Binding Protein 20 3 4
  • KIAA0370 4 6
  • RANBP20 3 4
  • RAN Binding Protein 20 2
  • Exportin-6 3

External Ids for XPO6 Gene

Previous HGNC Symbols for XPO6 Gene

  • RANBP20

Previous GeneCards Identifiers for XPO6 Gene

  • GC16M028207
  • GC16M028031
  • GC16M028075
  • GC16M028016
  • GC16M026200

Summaries for XPO6 Gene

Entrez Gene Summary for XPO6 Gene

  • The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for XPO6 Gene

XPO6 (Exportin 6) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot for XPO6 Gene

  • Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Gene Wiki entry for XPO6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO6 Gene

Genomics for XPO6 Gene

Regulatory Elements for XPO6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for XPO6 Gene

Start:
28,097,976 bp from pter
End:
28,211,960 bp from pter
Size:
113,985 bases
Orientation:
Minus strand

Genomic View for XPO6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XPO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO6 Gene

Proteins for XPO6 Gene

  • Protein details for XPO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QU8-XPO6_HUMAN
    Recommended name:
    Exportin-6
    Protein Accession:
    Q96QU8
    Secondary Accessions:
    • A1L3W4
    • D3DWF9
    • Q2YDX3
    • Q53G88
    • Q68G50
    • Q76N88
    • Q96CP8
    • Q9BT21

    Protein attributes for XPO6 Gene

    Size:
    1125 amino acids
    Molecular mass:
    128883 Da
    Quaternary structure:
    • Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.
    SequenceCaution:
    • Sequence=BAA20825.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for XPO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XPO6 Gene

Proteomics data for XPO6 Gene at MOPED

Post-translational modifications for XPO6 Gene

  • Ubiquitination at Lys288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for XPO6 Gene

Domains for XPO6 Gene

Gene Families for XPO6 Gene

HGNC:
  • XPO :Exportins

Protein Domains for XPO6 Gene

Suggested Antigen Peptide Sequences for XPO6 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QU8

UniProtKB/Swiss-Prot:

XPO6_HUMAN :
  • Q96QU8
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO6: view

Function for XPO6 Gene

Molecular function for XPO6 Gene

UniProtKB/Swiss-Prot Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Gene Ontology (GO) - Molecular Function for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 14592989
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IDA 14592989
genes like me logo Genes that share ontologies with XPO6: view

Phenotypes for XPO6 Gene

genes like me logo Genes that share phenotypes with XPO6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for XPO6 Gene

Localization for XPO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO6 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPO6 Gene COMPARTMENTS Subcellular localization image for XPO6 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with XPO6: view

Pathways for XPO6 Gene

SuperPathways for XPO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA 14592989
GO:0006886 intracellular protein transport --
genes like me logo Genes that share ontologies with XPO6: view

No data available for Pathways by source for XPO6 Gene

Transcripts for XPO6 Gene

Unigene Clusters for XPO6 Gene

Exportin 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XPO6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for XPO6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b · 28c · 28d · 28e
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:

Relevant External Links for XPO6 Gene

GeneLoc Exon Structure for
XPO6
ECgene alternative splicing isoforms for
XPO6

Expression for XPO6 Gene

mRNA expression in normal human tissues for XPO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XPO6 Gene

This gene is overexpressed in Whole Blood (20.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPO6 Gene

SOURCE GeneReport for Unigene cluster for XPO6 Gene Hs.460468

genes like me logo Genes that share expressions with XPO6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for XPO6 Gene

Orthologs for XPO6 Gene

This gene was present in the common ancestor of animals.

Orthologs for XPO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO6 35
  • 99.7 (n)
  • 99.91 (a)
XPO6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XPO6 35
  • 93.36 (n)
  • 98.04 (a)
XPO6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO6 35
  • 94.01 (n)
  • 98.84 (a)
XPO6 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo6 35
  • 91.01 (n)
  • 97.86 (a)
Xpo6 16
Xpo6 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPO6 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Xpo6 35
  • 90.93 (n)
  • 97.6 (a)
chicken
(Gallus gallus)
Aves XPO6 35
  • 84 (n)
  • 93.86 (a)
XPO6 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPO6 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7298 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491765 35
  • 73.73 (n)
  • 80.94 (a)
Str.7195 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5198 35
zebrafish
(Danio rerio)
Actinopterygii xpo6 35
  • 69.41 (n)
  • 74.89 (a)
xpo6 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Exp6 36
  • 25 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13929 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for XPO6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XPO6 Gene

ENSEMBL:
Gene Tree for XPO6 (if available)
TreeFam:
Gene Tree for XPO6 (if available)

Paralogs for XPO6 Gene

Pseudogenes.org Pseudogenes for XPO6 Gene

genes like me logo Genes that share paralogs with XPO6: view

No data available for Paralogs for XPO6 Gene

Variants for XPO6 Gene

Sequence variations from dbSNP and Humsavar for XPO6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11291 -- 28,098,194(-) AGTGC(C/T)ACCTT utr-variant-3-prime
rs14672 - 28,101,649(-) TGAAC(G/T)TGCTG reference, missense
rs33037 -- 28,131,864(-) GGCTG(C/T)TGTTT intron-variant
rs33038 -- 28,130,047(-) GGGCC(A/G)CGTTG intron-variant
rs33039 -- 28,128,499(-) TCAGC(A/G)GGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPO6 Gene

Variant ID Type Subtype PubMed ID
nsv469663 CNV Loss 16826518
nsv9408 CNV Gain 18304495
esv2656622 CNV Deletion 23128226
nsv9409 CNV Gain 18304495
dgv842e1 CNV Complex 17122850
nsv507812 CNV Insertion 20534489
nsv103104 CNV Loss 16902084
nsv525423 CNV Gain 19592680
nsv9410 CNV Gain 18304495

Relevant External Links for XPO6 Gene

HapMap Linkage Disequilibrium report
XPO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO6 Gene

Disorders for XPO6 Gene

Relevant External Links for XPO6

Genetic Association Database (GAD)
XPO6
Human Genome Epidemiology (HuGE) Navigator
XPO6
genes like me logo Genes that share disorders with XPO6: view

No data available for UniProtKB/Swiss-Prot for XPO6 Gene

Publications for XPO6 Gene

  1. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. (PMID: 14592989) Stueven T. … Goerlich D. (EMBO J. 2003) 2 3 4 23
  2. DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. (PMID: 16847355) Suzuki T. … Isemura M. (Biomed. Res. 2006) 3 23
  3. Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. (PMID: 18614847) Suzuki T. … Isemura M. (Biomed. Res. 2008) 3 23
  4. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. (PMID: 18676839) Ambs S. … Croce C.M. (Cancer Res. 2008) 3 23
  5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4

Products for XPO6 Gene

Sources for XPO6 Gene

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