V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

XPO6 Gene

protein-coding   GIFtS: 59

GC16M028016
exportin 6
(Previous name: RAN binding protein 20 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RANBP20)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
EXP6 2, 5
Exp6 3
FLJ22519 1, 2
KIAA0370 1, 2, 3, 5
RANBP20 2, 3
Descriptions
RAN binding protein 20 1, 2
Ran-binding protein 20 3
exportin 6 2
External Ids
HGNC: 197331
Entrez Gene: 232142
UniProtKB: Q96QU83
Ensembl: ENSG000001691807
Search outside databases for aliases for XPO6 gene

Previous GC identifers: GC16M028207 GC16M028031 GC16M028075

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XPO6:
Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of RAN (MIM 601179)-GTP
and form ternary export complexes. These complexes are transported through nuclear pore complexes
to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.[supplied by
OMIM]

UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8
Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells

Gene Wiki entry for XPO6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XPO6 gene  

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

XPO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028016:     (about GC identifiers)

Start:
28,016,817 bp from pter
End:
28,130,691 bp from pter
Size:
113,875 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8 (See protein sequence)
Recommended Name: Exportin-6  
Size: 1125 amino acids; 128883 Da
Subunit: Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB
in a RanGTP-dependent manner
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
Secondary accessions: Q2YDX3 Q53G88 Q68G50 Q76N88 Q96CP8 Q9BT21

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055986.1  

    ENSEMBL proteins: 
    ENSP00000302790 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (XPO6)
    Human Recombinant Proteins from Abnova (XPO6)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IC14592989
    GO:0005643 nuclear pore IEA--
    GO:0005737 cytoplasm IC14592989
    About this table

    Antibodies for XPO6: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (XPO6), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibody for XPO6

    Assays for XPO6: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-b_N


       GeneDecks  XPO6 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q96QU8

    ProtoNet protein and cluster: Q96QU8

    1 Blocks protein family: IPB013598 Exportin 1-like

    UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8
    Similarity: Belongs to the exportin family
    Similarity: Contains 1 importin N-terminal domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XPO6)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XPO6)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015171

                  Applied Biosystems Silencer® siRNAs for XPO6

                  Sigma-Aldrich siRNA for XPO6  
                         Sigma-Aldrich shRNA for XPO6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015171
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015171
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_015171 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015171

    UniProtKB/Swiss-Prot: XPO6_HUMAN, Q96QU8
    Function: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI14592989
    GO:0008565 protein transporter activity IDA14592989
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    4 Interacting proteins for XPO6 (Q96QU81, 2 ENSP000003027903) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF2Q9HAW01EBI-1022896, EBI-1055224
    GSK3BP498411EBI-1022896, EBI-373586
    NUP62P371982MINT-66588
    PFN1ENSP000002256553STRING (score=.853)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000059 protein import into nucleus, docking IEA--
    GO:0006611 protein export from nucleus IDA14592989
    GO:0006886 intracellular protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XPO6

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XPO6)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XPO6)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015171

                  Sigma-Aldrich siRNA for XPO6  
                         Sigma-Aldrich shRNA for XPO6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015171  

    REFSEQ mRNAs for XPO6 gene: 

    NM_015171.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015171  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015171
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015171
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_015171 

    Additional cDNA sequence: 

    AB002368.3 AK026172.1 AK123846.1 AK223043.1 AY026388.1 BC004403.1 BC014071.2 BC078674.1 
    BC108286.1 BC130304.1 BC144189.1 CR601489.1 CR618868.1 CR626761.1 

    24/27 DOTS entries (see all 27 ):

    DT.86859944  DT.101957099  DT.99962948  DT.97766368  DT.100892148  DT.40115087  DT.95256299  DT.120725157 
    DT.120725170  DT.91775695  DT.100829083  DT.100892115  DT.120725236  DT.91775699  DT.97779291  DT.100834878 
    DT.100892163  DT.120725174  DT.120725191  DT.120725250  DT.120725270  DT.92059594  DT.95086476  DT.95163788 

    24/559 AceView cDNA sequences (see all 559 ):

    BM828332 AV659602 BQ065612 BQ066084 BQ069898 AI651251 BC004403 BM505347 
    BM453784 BE887989 BU733132 BU164216 AA406606 AW468178 BP872070 BQ064271 
    BX505092 BE265209 BQ647500 AI189518 BQ000534 BG743169 AI189326 BF924445 

    highest scoring ESTs for XPO6:

    AB002368 AK123846 AY026388 AA026169 AA027230 AA044962 AA046211 AA113933 AA114000 AA126434 

    Unigene Cluster for XPO6:

    Exportin 6
    Hs.460468  [show with all ESTs]
    Unigene Representative Sequence: NM_015171


    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for XPO6 (see all 13 )

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                    -                       -                                         -     -     -                                                         
    SP2:              -     -                       -                                         -     -     -                                                         
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b · 28c · 28d · 28e
    SP1:                                                  -                       -                                 
    SP2:                                                  -                       -                                 
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                  -                                                         

    About this scheme

    ECgene alternative splicing isoforms for XPO6

    1 Ensembl transcript including schematic representation:
    ENST00000304658  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XPO6 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XPO6

    1 / 2 / 3

    5 probe-sets matching XPO6 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    35830_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB002368 1.00 1.00 1.00 1

    211982_x_at2, 3 U133-A 1 1.00 1.00 -- -- AL546600 0.60 1.00 0.82 1

    214784_x_at2, 3 U133-A 1 1.00 1.00 -- -- BE966299 0.60 1.00 0.82 1

    211982_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    214784_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGGCAGAATT

    SOURCE GeneReport for Unigene cluster: Hs.460468

    Expression variation in blood from EXPOLDB for XPO6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for XPO6 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    XPO61   -- exportin 6 99.67(n)
    99.91(a)
    454011  XM_001138416.1  XP_001138416.1 
    cow
    (Bos taurus)
    XPO61   -- exportin 6 93.39(n)
    98.04(a)
    510797  XM_865702.2  XP_870795.2 
    rat
    (Rattus norvegicus)
    Xpo61   -- exportin 6 90.96(n)
    97.6(a)
    293476  XM_574559.2  XP_574559.2 
    mouse
    (Mus musculus)
    Xpo61, 5 75
    exportin 61, 5 91.1(n)1
    97.95(a)1
    742041  NM_028816.21  NP_083092.21 
     AA0327575  AB0932355  (see all 40)
    chicken
    (Gallus gallus)
    XPO61   -- exportin 6 84.05(n)
    93.95(a)
    416410  XM_414725.2  XP_414725.2 
    About this table        Species with no ortholog for XPO6

    ENSEMBL Gene Tree for XPO6
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/617 NCBI SNPs in XPO6 are shown (see all 617 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 188)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs80491411,2
    F,H28016957(+) CTTGAC/TAGAAG 1 -- ut31 ese34Minor allele frequency- T:0.01EU EA WA 418
    rs80499921,2
    F,H28017246(+) CTTGCG/AGTGGG 1 -- ut31 ese34Minor allele frequency- A:0.01EU EA WA 418
    --
    rs75003501,2
    H28131264(+) AGGCAG/CAGAAT 1 -- ng314Minor allele frequency- C:0.00EU EA WA 416
    --
    rs99350741,2
    A28131858(+) cgcccA/Cgacta 1 -- ng310--------
    --
    rs43343041,2
    A28130575(+) ggcccC/GgAGGC 1 -- ut510--------
    rs146721,2
    F28020471(-) TGAACG/TTGCTG 1 V/L mis11Minor allele frequency- T:0.03MN 184
    --
    rs99353141,2
    A28131859(+) gcccaC/Gactag 1 -- ng310--------
    rs2053841,2
    A,C,F,H28030727(+) CTGGCG/ATGGTT 1 H/H syn19Minor allele frequency- A:0.20MN NA EU EA WA 772
    rs1817601,2
    C,F,H28052666(-) TCCACA/TCTGGT 1 T/T syn1 ese35Minor allele frequency- T:0.09EU EA WA NA 438
    rs116455861,2
    H28030687(+) CTTCAG/AGTTGC 1 L/L syn14Minor allele frequency- A:0.00EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for XPO6 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608411

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/16 PubMed articles for XPO6 gene (see all 16 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 23214 HGNC: 19733 AceView: XPO6 Ensembl:ENSG00000169180 euGenes: HUgn23214
    ECgene: XPO6 H-InvDB: XPO6
    (According to HUGE)
    About This Section

    HUGE: KIAA0370
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XPO6:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XPO6-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for XPO6 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for XPO6 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (XPO6)
     Search for Antibodies
     Chimera RNAi (XPO6)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (XPO6)
     Antibodies (XPO6)
     Search OriGene for XPO6
     Search Tocris compounds for XPO6




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for XPO6

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    XPO6 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com