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XPO5 Gene

protein-coding GIFtS: 59

GC06M043598

exportin 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Exp5 ^³
FLJ14239 ^²
FLJ32057 ^²
FLJ45606 ^²
KIAA1291 ^¹, ², ³, ⁵
RANBP21 ^³

Descriptions
Ran-binding protein 21 ^³
exportin 5 ^²

External Ids
HGNC: 17675¹
Entrez Gene: 57510²
UniProtKB: Q9HAV4³
Ensembl: ENSG00000124571⁷

Search outside databases for aliases for XPO5 gene

Previous GC identifers: GC06M043492 GC06M043536

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XPO5:

Exportin-5 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of

proteins and other cargo between the nuclear and cytoplasmic compartments.[supplied by OMIM]

UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4

Function: Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also

mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and

adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and

aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a

sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length

of at least 15 base-pairs. Binding is dependent on Ran-GTP

Gene Wiki entry for XPO5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XPO5 gene

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

XPO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M043598: (about GC identifiers)

Start:	43,598,050 bp from pter
End:	43,654,163 bp from pter
Size:	56,114 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4 (See protein sequence)

Recommended Name: Exportin-5

Size: 1204 amino acids; 136311 Da

Subunit: Component of a nuclear export receptor complex composed of XPO5, Ran, dsRNA-binding

proteins and dsRNA. Found in a nuclear export complex with XPO5, Ran, EEF1A1, and aminoacylated

tRNA. Found in a nuclear export complex with XPO5, Ran, ILF3 and dsRNA. Found in a nuclear export

complex with XPO5, Ran and pre-miRNA. Found in a nuclear export complex with XPO5, Ran, ILF3 and

minihelix VA1 dsRNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and dsRNA.

Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346. Interacts with Ran and cargo proteins in a

GTP-dependent manner

Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm

Sequence caution: Sequence=CAI42640.1; Type=Erroneous gene model prediction;

Secondary accessions: Q5JTE6 Q96G48 Q96HN3 Q9BWM6 Q9BZV5 Q9H9M4 Q9NT89 Q9NW39 Q9ULC9

Alternative splicing: 2 isoforms: Q9HAV4-1 Q9HAV4-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_065801.1

ENSEMBL proteins:

ENSP00000381816 ENSP00000361326 ENSP00000361332 ENSP00000361324 ENSP00000381779 ENSP00000265351

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Exportin-5)
	Human Recombinant Proteins from Abnova (XPO5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for XPO5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XPO5
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Exportin-5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XPO5)
	Novus Biologicals Antibodies for XPO5

Assays for XPO5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9HAV4

ProtoNet protein and cluster: Q9HAV4

UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4

Similarity: Belongs to the exportin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XPO5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XPO5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020750

Applied Biosystems Silencer® siRNAs for XPO5

Sigma-Aldrich siRNA for XPO5

Sigma-Aldrich shRNA for XPO5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XPO5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020750
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020750
untagged cDNA clones in CMV expression vector (see all 2): NM_020750

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020750

UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4

Function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain

(dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and

to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this

trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is

mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the

cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause

disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to

the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of

transport. The directionality of nuclear export is thought to be conferred by an asymmetric

distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi)

Function: Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also

mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and

adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and

aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a

sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length

of at least 15 base-pairs. Binding is dependent on Ran-GTP

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000049	tRNA binding	IEA	--
GO:0005515	protein binding	IPI	12702765 17353931
GO:0008565	protein transporter activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for XPO5

5/18 Interacting proteins for XPO5 (Q9HAV4¹ ENSP00000265351³) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FADD	Q13158¹, ENSP00000301838³	EBI-517949, EBI-494804 STRING (score=.746)
GSTK1	Q9Y2Q3¹	EBI-517949, EBI-1053767
MAGEA6	P43360¹	EBI-517949, EBI-1045155
NEK6	Q9HC98¹	EBI-517949, EBI-740364
PHLDA3	Q9Y5J5¹	EBI-517949, EBI-1055859

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006611	protein export from nucleus	IEA	--
GO:0015031	protein transport	IEA	--
GO:0031047	gene silencing by RNA	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XPO5
1 Novoseek chemical compound relationship for XPO5 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
trna	43.69	2	16963774 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XPO5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XPO5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020750

Sigma-Aldrich siRNA for XPO5

Sigma-Aldrich shRNA for XPO5

Explore Sigma-Aldrich super-pooled esiRNAs

REFSEQ mRNAs for XPO5 gene:

NM_020750.2

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020750
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020750
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_020750

Additional cDNA sequence:

AB033117.2 AF271159.1 AF298880.1 AK001195.1 AK022718.1 AK023431.1 AK024301.1 AK025864.1

AK127513.1 AK291452.1 AL137467.1 AL834207.1 BC000129.1 BC008347.1 BC009969.2 BC062635.1

CR597693.1

24 DOTS entries:

DT.101970772 DT.100811606 DT.117479 DT.100811608 DT.99995909 DT.99997262 DT.121405758 DT.91659446

DT.121405494 DT.101980818 DT.121405378 DT.100037823 DT.121405666 DT.100811605 DT.121405328 DT.40269817

DT.92447587 DT.92447592 DT.92447595 DT.100811609 DT.75131516 DT.75157158 DT.92447588 DT.92447594

24/327 AceView cDNA sequences (see all 327 ):

BM842068 BM709806 CA419664 BQ673134 CA442986 CR597693 BM558485 BM841722

BC000129 AA709255 BQ065867 BE900509 AU125578 BM799882 AF271159 AW137523

D25805 AU125748 BM829018 CD365777 BI858213 BQ227498 AB033117 NM_020750

highest scoring ESTs for XPO5:

AA148837 AA404723 AL514614 BM473797 BM560745 BM799882 BM833885 BX383435 BX642946 CB989586

Unigene Cluster for XPO5:

Exportin 5

Hs.203206 [show with all ESTs]

Unigene Representative Sequence: NM_020750

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000398835 ENST00000372252 ENST00000372258 ENST00000372250 ENST00000398799 ENST00000265351

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XPO5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XPO5

¹ / ² / ³

9 probe-sets matching XPO5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
72060_at²^{, 3}	U95-E	1	1.00	1.00	0.35	0.96	AA404723	0.80	1.00	0.91	1
55709_at²^{, 3}	U95-B	1	1.00	1.00	0.69	1.19	AA148837	0.80	1.00	0.91	1
78327_at²^{, 3}	U95-E	1	1.00	1.00	0.79	0.87	W22576	0.40	1.00	0.76	1
223055_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF271159	0.80	0.83	0.82	1
223057_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC000129	0.60	0.75	0.68	1
223056_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF298880	0.80	0.83	0.82	1
223055_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223057_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223056_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks XPO5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCAGTAAAAA

SOURCE GeneReport for Unigene cluster: Hs.203206
UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4
Tissue specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XPO5 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XPO5¹	--	exportin 5	92.78(n) 95.5(a)	474913 XM_532148.2 XP_532148.2
mouse (Mus musculus)	Xpo5^{1, 5}	17⁵	exportin 5^{1, 5}	86.49(n)¹ 87.71(a)¹	72322¹ NM_028198.2¹ NP_082474.1¹ AA638918⁵ AF343581⁵ (see all 22)
chicken (Gallus gallus)	XPO5¹	--	exportin 5	76.59(n) 83.69(a)	421450 XM_419501.2 XP_419501.2
zebrafish (Danio rerio)	LOC558662¹	--	similar to exportin 5	64.05(n) 61.6(a)	558662 XM_001921387.1 XP_001921422.1
fruit fly (Drosophila melanogaster)	Ranbp21^{1, 3}	18D12--13³	RAN protein binding³ Ranbp21¹	35(a)³ 47.26(n)¹ 37.29(a)¹	32970¹ NM_134495.2¹ NP_608339.2¹

About this table Species with no ortholog for XPO5

ENSEMBL Gene Tree for XPO5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/203 NCBI SNPs in XPO5 are shown (see all 203 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 75)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs34324334^1,2	C,F	43642996(+)	`TGTGAC/TTCATA`	1	S/N	mis¹		5	NA EU EA WA	498
	rs12173786^1,2	C,H	43625234(+)	`CACATC/GTTGAT`	1	K/N	mis¹		4	EU EA WA	414
--	rs11544379^1,2	H	43627087(-)	`CCTGCG/TTCCTT`	1	V/F	mis¹ ese³		4	EU EA WA	406
	rs6916623^1,2	C,F,H	43631567(+)	`CCAGCA/GTCAAG`	1	D/D	syn¹		5	EU EA WA	598
	rs699937^1,2	A,C,F,H,O	43648904(-)	`GCCCTC/TGAAGC`	1	--	int¹		13	MN EA NA EU WA	1270
	rs6458342^1,2	A,C,F,H	43647118(+)	`AAGACG/ACAGAA`	1	--	int¹		8	EU EA WA	826
	rs6928412^1,2	A,C,F,H	43624206(+)	`AGAGGT/CGGTAA`	1	--	int¹		4	EU EA WA	406
	rs7748977^1,2	A,C,F,H	43621785(+)	`AAGGAT/CCTAGC`	1	--	int¹		5	EU EA WA	598
	rs7767973^1,2	A,C,F,H	43609811(+)	`CAGTTT/CCACAC`	1	--	int¹		8	EU EA WA NA	736
	rs1564320^1,2	A,C,F,H	43623735(-)	`TTAGAA/GAAATG`	1	--	int¹		10	EA NA EU WA	820

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HapMap Linkage Disequilibrium images for XPO5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607845

Human Genome Epidemiology Navigator: XPO5 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/39 PubMed articles for XPO5 gene (see all 39 ):

Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)^{1, 2, 3, 4} Brownawell A.M. and Macara I.G. (2002)
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PubMed id 12426392)^{1, 2, 3, 4} Bohnsack M.T....Gorlich D. (2002)
Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PubMed id 15254228)^{1, 3, 4} Chen T.... Macara I.G. (2004)
Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. (PubMed id 15613540)^{1, 3, 4} Yi R.... Cullen B.R. (2005)
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. (PubMed id 14681208)^{1, 3, 4} Yi R.... Cullen B.R. (2003)
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. (PubMed id 14730017)^{1, 3, 4} Bohnsack M.T.... Goerlich D. (2004)
Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PubMed id 14570900)^{1, 3, 4} Gwizdek C....Dargemont C. (2004)
Nuclear export of microRNA precursors. (PubMed id 14631048)^{1, 3, 4} Lund E.... Kutay U. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57510	HGNC: 17675	AceView: XPO5	Ensembl:ENSG00000124571	euGenes: HUgn57510
ECgene: XPO5	H-InvDB: XPO5

(According to HUGE)
About This Section

HUGE: KIAA1291

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for XPO5	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for XPO5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XPO5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XPO5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XPO5		Antibodies for XPO5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XPO5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (XPO5)
	Antibodies (XPO5)
	Chimera RNAi (XPO5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Exportin-5)
	Antibodies (Exportin-5)

Search OriGene for XPO5

Search Tocris compounds for XPO5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for XPO5

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XPO5 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for XPO5

Summaries
for XPO5

Genomic Location
for XPO5

Proteins
for XPO5

Protein Domains/
Families
for XPO5

Gene Function
for XPO5

Pathways & Interactions
for XPO5

Drugs & Compounds
for XPO5

Transcripts
for XPO5

Expression
for XPO5

Orthologs
for XPO5

Paralogs
for XPO5

SNPs/Variants
for XPO5

Disorders & Mutations
for XPO5

Medical News
for XPO5

Publications
for XPO5

Search for XPO5

Genome Databases showing XPO5

Other Databases showing XPO5

Specialized Databases showing XPO5

Licensable Technologies
for XPO5

Services
for XPO5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XPO5 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor XPO5

Summariesfor XPO5

Genomic Locationfor XPO5

Proteinsfor XPO5

Protein Domains/Familiesfor XPO5

Gene Functionfor XPO5

Pathways & Interactionsfor XPO5

Drugs & Compoundsfor XPO5

Transcriptsfor XPO5

Expression for XPO5

Orthologsfor XPO5

Paralogsfor XPO5

SNPs/Variantsfor XPO5

Disorders & Mutationsfor XPO5

Medical Newsfor XPO5

Publicationsfor XPO5

Search for XPO5

Genome Databases showing XPO5

Other Databases showing XPO5

Specialized Databases showing XPO5

Licensable Technologiesfor XPO5

Servicesfor XPO5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XPO5

Summaries
for XPO5

Genomic Location
for XPO5

Proteins
for XPO5

Protein Domains/
Families
for XPO5

Gene Function
for XPO5

Pathways & Interactions
for XPO5

Drugs & Compounds
for XPO5

Transcripts
for XPO5

Expression
for XPO5

Orthologs
for XPO5

Paralogs
for XPO5

SNPs/Variants
for XPO5

Disorders & Mutations
for XPO5

Medical News
for XPO5

Publications
for XPO5

Licensable Technologies
for XPO5

Services
for XPO5