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Aliases for XPO5 Gene

Aliases for XPO5 Gene

  • Exportin 5 2 3 5
  • Ran-Binding Protein 21 3 4
  • Exp5 3 4
  • KIAA1291 4
  • RANBP21 4

External Ids for XPO5 Gene

Previous GeneCards Identifiers for XPO5 Gene

  • GC06M043492
  • GC06M043536
  • GC06M043598
  • GC06M043209

Summaries for XPO5 Gene

Entrez Gene Summary for XPO5 Gene

  • This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

GeneCards Summary for XPO5 Gene

XPO5 (Exportin 5) is a Protein Coding gene. Diseases associated with XPO5 include Unilateral Retinoblastoma. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for XPO5 Gene

  • Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.

  • Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5-overhang in a sequence-independent manner, have only a short 3-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.

Gene Wiki entry for XPO5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO5 Gene

Genomics for XPO5 Gene

Regulatory Elements for XPO5 Gene

Enhancers for XPO5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around XPO5 on UCSC Golden Path with GeneCards custom track

Promoters for XPO5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around XPO5 on UCSC Golden Path with GeneCards custom track

Genomic Location for XPO5 Gene

Chromosome:
6
Start:
43,522,330 bp from pter
End:
43,576,075 bp from pter
Size:
53,746 bases
Orientation:
Minus strand

Genomic View for XPO5 Gene

Genes around XPO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO5 Gene

Proteins for XPO5 Gene

  • Protein details for XPO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAV4-XPO5_HUMAN
    Recommended name:
    Exportin-5
    Protein Accession:
    Q9HAV4
    Secondary Accessions:
    • Q5JTE6
    • Q96G48
    • Q96HN3
    • Q9BWM6
    • Q9BZV5
    • Q9H9M4
    • Q9NT89
    • Q9NW39
    • Q9ULC9

    Protein attributes for XPO5 Gene

    Size:
    1204 amino acids
    Molecular mass:
    136311 Da
    Quaternary structure:
    • Component of a nuclear export receptor complex composed of XPO5, Ran, dsRNA-binding proteins and dsRNA. Found in a nuclear export complex with XPO5, Ran, EEF1A1, and aminoacylated tRNA. Found in a nuclear export complex with XPO5, Ran, ILF3 and dsRNA. Found in a nuclear export complex with XPO5, Ran and pre-miRNA. Found in a nuclear export complex with XPO5, Ran, ILF3 and minihelix VA1 dsRNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and dsRNA. Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346. Interacts with Ran and cargo proteins in a GTP-dependent manner. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM domains).
    SequenceCaution:
    • Sequence=AAH00129.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86605.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91547.1; Type=Frameshift; Positions=920; Evidence={ECO:0000305}; Sequence=CAI42640.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for XPO5 Gene

neXtProt entry for XPO5 Gene

Proteomics data for XPO5 Gene at MOPED

Post-translational modifications for XPO5 Gene

  • Ubiquitination at Lys 216, Lys 396, Lys 930, Lys 1140, Lys 1173, and Lys 1180
  • Modification sites at PhosphoSitePlus

Other Protein References for XPO5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for XPO5 (Exportin-5)

No data available for DME Specific Peptides for XPO5 Gene

Domains & Families for XPO5 Gene

Gene Families for XPO5 Gene

Protein Domains for XPO5 Gene

Suggested Antigen Peptide Sequences for XPO5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAV4

UniProtKB/Swiss-Prot:

XPO5_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO5: view

Function for XPO5 Gene

Molecular function for XPO5 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.
UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5-overhang in a sequence-independent manner, have only a short 3-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.

Gene Ontology (GO) - Molecular Function for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003729 mRNA binding IDA 21297638
GO:0005488 binding IEA --
GO:0008536 Ran GTPase binding IEA,IPI 14681208
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with XPO5: view
genes like me logo Genes that share phenotypes with XPO5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO5 Gene

Localization for XPO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO5 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPO5 Gene COMPARTMENTS Subcellular localization image for XPO5 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11777942
GO:0042565 RNA nuclear export complex IDA 14681208
genes like me logo Genes that share ontologies with XPO5: view

Pathways & Interactions for XPO5 Gene

genes like me logo Genes that share pathways with XPO5: view

Pathways by source for XPO5 Gene

1 Cell Signaling Technology pathway for XPO5 Gene
1 KEGG pathway for XPO5 Gene

Gene Ontology (GO) - Biological Process for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IEA,IDA 11777942
GO:0031047 gene silencing by RNA TAS --
genes like me logo Genes that share ontologies with XPO5: view

No data available for SIGNOR curated interactions for XPO5 Gene

Drugs & Compounds for XPO5 Gene

(1) Drugs for XPO5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for XPO5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XPO5: view

Transcripts for XPO5 Gene

Unigene Clusters for XPO5 Gene

Exportin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XPO5 Gene

No ASD Table

Relevant External Links for XPO5 Gene

GeneLoc Exon Structure for
XPO5
ECgene alternative splicing isoforms for
XPO5

Expression for XPO5 Gene

mRNA expression in normal human tissues for XPO5 Gene

Protein differential expression in normal tissues from HIPED for XPO5 Gene

This gene is overexpressed in Bone (60.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPO5 Gene



SOURCE GeneReport for Unigene cluster for XPO5 Gene Hs.203206

mRNA Expression by UniProt/SwissProt for XPO5 Gene

Q9HAV4-XPO5_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with XPO5: view

Protein tissue co-expression partners for XPO5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for XPO5 Gene

Orthologs for XPO5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XPO5 35
  • 91.32 (n)
  • 94.99 (a)
XPO5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO5 35
  • 92.92 (n)
  • 95.89 (a)
XPO5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo5 35
  • 86.52 (n)
  • 87.71 (a)
Xpo5 16
Xpo5 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XPO5 35
  • 99.64 (n)
  • 99.75 (a)
XPO5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xpo5 35
  • 87.15 (n)
  • 87.62 (a)
oppossum
(Monodelphis domestica)
Mammalia XPO5 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves XPO5 35
  • 76.74 (n)
  • 83.89 (a)
XPO5 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPO5 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpo5 35
xpo5 35
  • 63.34 (n)
  • 59.43 (a)
zebrafish
(Danio rerio)
Actinopterygii xpo5 35
  • 63.74 (n)
  • 60.81 (a)
XPO5 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ranbp21 37
  • 35 (a)
Ranbp21 35
  • 47.21 (n)
  • 37.55 (a)
Ranbp21 36
  • 35 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011888 35
  • 48.31 (n)
  • 38.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSN5 36
  • 18 (a)
OneToOne
MSN5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HST 35
  • 39.99 (n)
  • 26.68 (a)
rice
(Oryza sativa)
Liliopsida Os01g0363900 35
  • 38.62 (n)
  • 25.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for XPO5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XPO5 Gene

ENSEMBL:
Gene Tree for XPO5 (if available)
TreeFam:
Gene Tree for XPO5 (if available)

Paralogs for XPO5 Gene

No data available for Paralogs for XPO5 Gene

Variants for XPO5 Gene

Sequence variations from dbSNP and Humsavar for XPO5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_028032 -
rs34324334 - 43,567,281(+) TGTGA(C/T)TCATA reference, missense
rs1096699 -- 43,560,704(-) ATTCT(A/G)ATTGT intron-variant
rs1096700 -- 43,552,622(-) taatc(C/G)cagca intron-variant
rs1144711 -- 43,569,309(+) aacaa(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPO5 Gene

Variant ID Type Subtype PubMed ID
nsv818414 CNV Gain 17921354
dgv6842n71 CNV Loss 21882294

Variation tolerance for XPO5 Gene

Residual Variation Intolerance Score: 9.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XPO5 Gene

Human Gene Mutation Database (HGMD)
XPO5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO5 Gene

Disorders for XPO5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for XPO5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
unilateral retinoblastoma
- elite association - COSMIC cancer census association via MalaCards
Search XPO5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for XPO5

Genetic Association Database (GAD)
XPO5
Human Genome Epidemiology (HuGE) Navigator
XPO5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XPO5
genes like me logo Genes that share disorders with XPO5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPO5 Gene

Publications for XPO5 Gene

  1. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PMID: 11777942) Brownawell A.M. … Macara I.G. (J. Cell Biol. 2002) 2 3 4 23 67
  2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PMID: 12426392) Bohnsack M.T. … Goerlich D. (EMBO J. 2002) 2 3 23
  3. RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PMID: 19124606) Fritz J. … Jantsch M.F. (Mol. Cell. Biol. 2009) 3 23
  4. A high-resolution structure of the pre-microRNA nuclear export machinery. (PMID: 19965479) Okada C. … Tsukihara T. (Science 2009) 3 23
  5. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. (PMID: 15613540) Yi R. … Cullen B.R. (RNA 2005) 3 23

Products for XPO5 Gene

Sources for XPO5 Gene

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