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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XPO5 Gene

protein-coding   GIFtS: 62
GCID: GC06M043490

Exportin 5

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Exportin 51 2     exportin-52
Ran-Binding Protein 212 3     Exp53
KIAA12913 5     RANBP213
exp52     

External Ids:    HGNC: 176751   Entrez Gene: 575102   Ensembl: ENSG000001245717   OMIM: 6078455   UniProtKB: Q9HAV43   

Export aliases for XPO5 gene to outside databases

Previous GC identifers: GC06M043492 GC06M043536 GC06M043598 GC06M043209


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XPO5 Gene:
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and
double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo
through the nuclear pore complex in a RanGTP-dependent process. (provided by RefSeq, Aug 2011)

GeneCards Summary for XPO5 Gene: 
XPO5 (exportin 5) is a protein-coding gene. Diseases associated with XPO5 include pleuropulmonary blastoma, and blastoma, and among its related super-pathways are MicroRNA (miRNA) Biogenesis and Generic Transcription Pathway. GO annotations related to this gene include RNA binding and tRNA binding.

UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4
Function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and
double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its
active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA.
Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon
transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and
RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5
then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round
of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of
the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances
enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a
RanGTP-dependent manner
Function: Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the
nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some
circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes
dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a
double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

Gene Wiki entry for XPO5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XPO5 gene promoter:
         Elk-1   RP58   Bach2   CUTL1   Nkx2-5   POU3F2   PPAR-gamma1   c-Myb   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPO5 promoter sequence
   Search SABiosciences Chromatin IP Primers for XPO5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPO5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

XPO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M043490:  view genomic region     (about GC identifiers)

Start:
43,490,068 bp from pter      End:
43,543,812 bp from pter
Size:
53,745 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4 (See protein sequence)
Recommended Name: Exportin-5  
Size: 1204 amino acids; 136311 Da
Subunit: Component of a nuclear export receptor complex composed of XPO5, Ran, dsRNA-binding proteins and dsRNA.
Found in a nuclear export complex with XPO5, Ran, EEF1A1, and aminoacylated tRNA. Found in a nuclear export
complex with XPO5, Ran, ILF3 and dsRNA. Found in a nuclear export complex with XPO5, Ran and pre-miRNA. Found in
a nuclear export complex with XPO5, Ran, ILF3 and minihelix VA1 dsRNA. Found in a nuclear export complex with
XPO5, RAN, ILF3, ZNF346 and dsRNA. Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346. Interacts with Ran and
cargo proteins in a GTP-dependent manner. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM domains)
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
Sequence caution: Sequence=AAH00129.1; Type=Erroneous initiation; Sequence=BAA86605.2; Type=Erroneous initiation;
Sequence=BAA91547.1; Type=Frameshift; Positions=920; Sequence=CAI42640.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for XPO5:
3A6P (3D)    
Secondary accessions: Q5JTE6 Q96G48 Q96HN3 Q9BWM6 Q9BZV5 Q9H9M4 Q9NT89 Q9NW39 Q9ULC9

Explore the universe of human proteins at neXtProt for XPO5: NX_Q9HAV4

Explore proteomics data for XPO5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HAV4

  • XPO5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    XPO5 Protein Expression
    REFSEQ proteins: NP_065801.1  
    ENSEMBL proteins: 
     ENSP00000265351   ENSP00000426185   ENSP00000387384   ENSP00000381816   ENSP00000424196  
     ENSP00000381779  
    Reactome Protein details: Q9HAV4
    Human Recombinant Protein Products for XPO5: 
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    Novus Biologicals XPO5 Protein
    Novus Biologicals XPO5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XPO5 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005643nuclear pore ----
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    XPO5 for ontologies           About GeneDecksing



    XPO5 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for XPO5 
    Cloud-Clone Corp. CLIAs for XPO5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    XPO: Exportins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9HAV4

    ProtoNet protein and cluster: Q9HAV4

    UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4
    Similarity: Belongs to the exportin family


    XPO5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPO5_HUMAN, Q9HAV4
    Function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and
    double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its
    active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA.
    Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon
    transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and
    RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5
    then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round
    of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of
    the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances
    enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a
    RanGTP-dependent manner
    Function: Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the
    nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some
    circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes
    dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a
    double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0003723RNA binding TAS--
    GO:0005488binding ----
    GO:0005515protein binding IPI19124606
    GO:0008536Ran GTPase binding IEA--
         
    XPO5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for XPO5:
     Increased G1 DNA content  Increased gamma-H2AX phosphory  Nuclear 60S biogenesis defects 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for XPO5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XPO5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XPO5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XPO5 

    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate XPO5 (see all 44):
    hsa-miR-576-3p hsa-miR-100* hsa-miR-513a-5p hsa-miR-29a hsa-miR-218 hsa-miR-766 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidXPO5 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for XPO5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulatory RNA pathways
    Regulatory RNA pathways0.88
    MicroRNA (miRNA) Biogenesis0.88
    2Generic Transcription Pathway
    Gene Expression0.47
    3RNA transport
    RNA transport
    4Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for XPO5
        Translational Control

    3        Reactome Pathways for XPO5
        MicroRNA (miRNA) Biogenesis
    Regulatory RNA pathways
    Gene Expression


    1         Kegg Pathway  (Kegg details for XPO5):
        RNA transport


    XPO5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XPO5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/658 Interacting proteins for XPO5 (Q9HAV42, 3 ENSP000002653514) via UniProtKB, MINT, STRING, and/or I2D (see all 658)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FADDQ131582, 3, ENSP000003018384MINT-45871 I2D: score=3 STRING: ENSP00000301838
    ACTBP607092, 3MINT-7947479 I2D: score=2 
    DNAJA1P316892, 3MINT-7947479 I2D: score=2 
    HSP90AA1P079002, 3MINT-7947479 I2D: score=2 
    IKBKGQ9Y6K92, 3MINT-48212 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006611protein export from nucleus IEA--
    GO:0006886intracellular protein transport ----
    GO:0010467gene expression TAS--
    GO:0031047gene silencing by RNA IEA--

    XPO5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    XPO5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XPO5

    1 HMDB Compound for XPO5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for XPO5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna 41.5 2 16963774 (1)

    Search CenterWatch for drugs/clinical trials and news about XPO5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for XPO5 gene: 
    NM_020750.2  

    Unigene Cluster for XPO5:

    Exportin 5
    Hs.203206  [show with all ESTs]
    Unigene Representative Sequence: NM_020750
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265351(uc003ovp.3) ENST00000455854 ENST00000488195 ENST00000486936
    ENST00000455285 ENST00000450462 ENST00000398835 ENST00000515657 ENST00000513451
    ENST00000496341 ENST00000424378 ENST00000398799
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate XPO5 (see all 44):
    hsa-miR-576-3p hsa-miR-100* hsa-miR-513a-5p hsa-miR-29a hsa-miR-218 hsa-miR-766 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidXPO5 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPO5

    Additional mRNA sequence: 

    AB033117.2 AF271159.1 AF298880.1 AK001195.1 AK022718.1 AK023431.1 AK024301.1 AK025864.1 
    AK127513.1 AK291452.1 AL137467.1 AL834207.1 BC000129.1 BC008347.1 BC009969.2 BC062635.1 

    24/25 DOTS entries (see all 25):

    DT.101970772  DT.100811606  DT.117479  DT.100811608  DT.99995909  DT.99997262  DT.121405758  DT.91659446 
    DT.121405494  DT.101980818  DT.121405378  DT.100037823  DT.121405666  DT.100811605  DT.121405328  DT.40269817 
    DT.92447587  DT.92447592  DT.92447595  DT.100811609  DT.75131516  DT.75157158  DT.92447588  DT.92447594 

    24/327 AceView cDNA sequences (see all 327):

    CB122399 BQ230268 AF271159 BU196479 BX397725 AB033117 AF298880 AA136496 
    T08016 BM762536 BM127692 BQ063192 BM841722 BM826842 AU133476 BU168979 
    BP353487 BQ069528 BM681940 Z42729 CR597693 BM829018 BM709806 AW135759 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XPO5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTAAAAA
    XPO5 Expression
    About this image


    See XPO5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XPO5

    SOURCE GeneReport for Unigene cluster: Hs.203206

    UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4
    Tissue specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPO5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPO5 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpo51 , 5 exportin 51, 5 86.52(n)1
    87.71(a)1
      17 (22.90 cM)5
    723221  NM_028198.21  NP_082474.11 
     462028555 
    chicken
    (Gallus gallus)
    Aves XPO51 exportin 5 76.59(n)
    83.69(a)
      421450  XM_419501.3  XP_419501.2 
    lizard
    (Anolis carolinensis)
    Reptilia XPO56
    exportin 5
    80(a)
    1 ↔ 1
    1(230969708-231021048)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ884365.12   -- 85.71(n)    BQ884365.1 
    zebrafish
    (Danio rerio)
    Actinopterygii xpo51 exportin 5 64.07(n)
    61.62(a)
      558662  XM_001921387.3  XP_001921422.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ranbp211 , 3 RAN protein binding3
    CG12234-PA1
    35(a)3
    47.29(n)1
    37.29(a)1
      329701  NM_134495.21  NP_608339.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSN5(YDR335W)4 Karyopherin involved in nuclear import and export of more   --   4(1141168-1144842) 851935  NP_010622.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HST1 protein HASTY 38.52(n)
    24.49(a)
      819666  NM_111376.3  NP_187155.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g03639001 hypothetical protein 37.64(n)
    23.12(a)
      4325820  NM_001049569.1  NP_001043034.1 


    ENSEMBL Gene Tree for XPO5 (if available)
    TreeFam Gene Tree for XPO5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1152 SNPs in XPO5 are shown (see all 1152)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018731371,2
    Cuntested143516084(+) TTAAAA/G/TTGGTT 2 Q H mis11EU 569
    rs596613011,2
    C--43244783(+) AAAAA-/A/AA  
            
    GGAGG
    1 -- int11NA 2
    rs38302121,2
    C--43409737(-) TCTGT-/GTTTCTA 1 -- int10--------
    rs1858604291,2
    --43489830(+) CAGTAA/GCAATT 1 -- int10--------
    rs1409454871,2
    C--43489854(+) CCCAG-/CAGC  
            
    CACAC
    1 -- int10--------
    rs758343371,2
    C,F--43489994(+) TGTTTT/CAGTCC 1 -- int11Minor allele frequency- C:0.02WA 118
    rs31771641,2
    C--43490075(-) GTACAG/AAAAGG 1 -- ut31 ese31Minor allele frequency- A:0.00NA 2
    rs1904897461,2
    --43490081(+) TGTACA/GAAACT 1 -- ut310--------
    rs1441280301,2
    C--43490198(+) TTACAA/GTGCAA 1 -- ut310--------
    rs1830565141,2
    --43490369(+) CTTTGA/CTTCTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for XPO5 (43490068 - 43543812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for XPO5:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6842n71CNV Loss21882294
    nsv818414CNV Gain17921354


    Human Gene Mutation Database (HGMD): XPO5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing XPO5
    DNA2.0 Custom Variant and Variant Library Synthesis for XPO5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607845    OMIM disorders: --

    9 diseases for XPO5:    About MalaCards
    pleuropulmonary blastoma    blastoma    esophageal cancer    renal cell carcinoma
    multiple myeloma    esophagitis    myeloma    colon cancer
    lung cancer

    1 disease from the University of Copenhagen DISEASES database for XPO5:
    Pleuropulmonary blastoma

    XPO5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): XPO5
    Human Genome Epidemiology (HuGE) Navigator: XPO5 (8 documents)

    Export disorders for XPO5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XPO5 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with XPO5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)1, 2, 3, 9 Brownawell A.M. and Macara I.G. (2002)
    2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PubMed id 12426392)1, 2, 3, 9 Bohnsack M.T.... Goerlich D. (2002)
    3. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PubMed id 15254228)1, 2, 9 Chen T.... Macara I.G. (2004)
    4. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. (PubMed id 15613540)1, 2, 9 Yi R.... Cullen B.R. (2005)
    5. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. (PubMed id 14681208)1, 2, 9 Yi R.... Cullen B.R. (2003)
    6. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. (PubMed id 14730017)1, 2, 9 Bohnsack M.T.... Goerlich D. (2004)
    7. Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PubMed id 14570900)1, 2, 9 Gwizdek C....Dargemont C. (2004)
    8. RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PubMed id 19124606)1, 2, 9 Fritz J....Jantsch M.F. (2009)
    9. Nuclear export of microRNA precursors. (PubMed id 14631048)1, 2, 9 Lund E.... Kutay U. (2004)
    10. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57510 HGNC: 17675 AceView: XPO5 Ensembl:ENSG00000124571 euGenes: HUgn57510
    ECgene: XPO5 Kegg: 57510 H-InvDB: XPO5

    (According to HUGE)
    About This Section
    HUGE: KIAA1291

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XPO5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XPO5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for XPO5 gene:
    Search GeneIP for patents involving XPO5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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