Free for academic non-profit institutions. Other users need a Commercial license

Aliases for XPO5 Gene

Aliases for XPO5 Gene

  • Exportin 5 2 3
  • Ran-Binding Protein 21 3 4
  • KIAA1291 4 6
  • Exp5 3 4
  • Exportin-5 3
  • RANBP21 4

External Ids for XPO5 Gene

Summaries for XPO5 Gene

Entrez Gene Summary for XPO5 Gene

  • This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

GeneCards Summary for XPO5 Gene

XPO5 (Exportin 5) is a Protein Coding gene. Diseases associated with XPO5 include blastoma and pleuropulmonary blastoma. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include RNA binding and tRNA binding.

UniProtKB/Swiss-Prot for XPO5 Gene

  • Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner

  • Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5-overhang in a sequence-independent manner, have only a short 3-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

Gene Wiki entry for XPO5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO5 Gene

Genomics for XPO5 Gene

Genomic Location for XPO5 Gene

Start:
43,522,330 bp from pter
End:
43,576,075 bp from pter
Size:
53,746 bases
Orientation:
Minus strand

Genomic View for XPO5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XPO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO5 Gene

Regulatory Elements for XPO5 Gene

Proteins for XPO5 Gene

  • Protein details for XPO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAV4-XPO5_HUMAN
    Recommended name:
    Exportin-5
    Protein Accession:
    Q9HAV4
    Secondary Accessions:
    • Q5JTE6
    • Q96G48
    • Q96HN3
    • Q9BWM6
    • Q9BZV5
    • Q9H9M4
    • Q9NT89
    • Q9NW39
    • Q9ULC9

    Protein attributes for XPO5 Gene

    Size:
    1204 amino acids
    Molecular mass:
    136311 Da
    Quaternary structure:
    • Component of a nuclear export receptor complex composed of XPO5, Ran, dsRNA-binding proteins and dsRNA. Found in a nuclear export complex with XPO5, Ran, EEF1A1, and aminoacylated tRNA. Found in a nuclear export complex with XPO5, Ran, ILF3 and dsRNA. Found in a nuclear export complex with XPO5, Ran and pre-miRNA. Found in a nuclear export complex with XPO5, Ran, ILF3 and minihelix VA1 dsRNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and dsRNA. Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346. Interacts with Ran and cargo proteins in a GTP-dependent manner. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM domains).
    SequenceCaution:
    • Sequence=AAH00129.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86605.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91547.1; Type=Frameshift; Positions=920; Evidence={ECO:0000305}; Sequence=CAI42640.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for XPO5 Gene

neXtProt entry for XPO5 Gene

Proteomics data for XPO5 Gene at MOPED

Post-translational modifications for XPO5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys216, Lys396, Lys930, Lys1140, Lys1173, and Lys1180

Other Protein References for XPO5 Gene

No data available for DME Specific Peptides for XPO5 Gene

Domains for XPO5 Gene

Gene Families for XPO5 Gene

HGNC:
  • XPO :Exportins

Protein Domains for XPO5 Gene

UniProtKB/Swiss-Prot:

XPO5_HUMAN
Family:
  • Belongs to the exportin family.:
    • Q9HAV4
genes like me logo Genes that share domains with XPO5: view

Function for XPO5 Gene

Molecular function for XPO5 Gene

UniProtKB/Swiss-Prot Function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner
UniProtKB/Swiss-Prot Function: Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5-overhang in a sequence-independent manner, have only a short 3-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

Gene Ontology (GO) - Molecular Function for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003723 RNA binding TAS --
GO:0003729 mRNA binding IDA 21297638
GO:0005488 binding --
GO:0005515 protein binding IPI 11777942
genes like me logo Genes that share ontologies with XPO5: view

Phenotypes for XPO5 Gene

genes like me logo Genes that share phenotypes with XPO5: view

miRNA for XPO5 Gene

miRTarBase miRNAs that target XPO5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for XPO5 Gene

Localization for XPO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO5 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPO5 Gene COMPARTMENTS Subcellular localization image for XPO5 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11777942
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0042565 RNA nuclear export complex IDA 14681208
genes like me logo Genes that share ontologies with XPO5: view

Pathways for XPO5 Gene

genes like me logo Genes that share pathways with XPO5: view

Pathways by source for XPO5 Gene

1 Cell Signaling Technology pathway for XPO5 Gene
1 KEGG pathway for XPO5 Gene

Gene Ontology (GO) - Biological Process for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA 11777942
GO:0006886 intracellular protein transport --
GO:0010467 gene expression TAS --
GO:0031047 gene silencing by RNA --
GO:0035281 pre-miRNA export from nucleus IMP 14681208
genes like me logo Genes that share ontologies with XPO5: view

Compounds for XPO5 Gene

(1) HMDB Compounds for XPO5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for XPO5 Gene

Compound -log(P) Hits PubMed IDs
trna 41.5 1
genes like me logo Genes that share compounds with XPO5: view

Transcripts for XPO5 Gene

Unigene Clusters for XPO5 Gene

Exportin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XPO5 Gene

No ASD Table

Relevant External Links for XPO5 Gene

GeneLoc Exon Structure for
XPO5
ECgene alternative splicing isoforms for
XPO5

Expression for XPO5 Gene

mRNA expression in normal human tissues for XPO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPO5 Gene

SOURCE GeneReport for Unigene cluster for XPO5 Gene Hs.203206

mRNA Expression by UniProt/SwissProt for XPO5 Gene

Q9HAV4-XPO5_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with XPO5: view

Orthologs for XPO5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO5 36
  • 99.64 (n)
  • 99.75 (a)
XPO5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XPO5 36
  • 91.32 (n)
  • 94.99 (a)
XPO5 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO5 36
  • 92.92 (n)
  • 95.89 (a)
XPO5 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo5 36
  • 86.52 (n)
  • 87.71 (a)
Xpo5 16
Xpo5 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPO5 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Xpo5 36
  • 87.15 (n)
  • 87.62 (a)
chicken
(Gallus gallus)
Aves XPO5 36
  • 76.74 (n)
  • 83.89 (a)
XPO5 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPO5 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpo5 36
xpo5 36
  • 63.34 (n)
  • 59.43 (a)
zebrafish
(Danio rerio)
Actinopterygii xpo5 36
  • 63.74 (n)
  • 60.81 (a)
XPO5 37
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011888 36
  • 48.31 (n)
  • 38.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp21 36
  • 47.21 (n)
  • 37.55 (a)
Ranbp21 37
  • 35 (a)
OneToOne
Ranbp21 38
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSN5 37
  • 18 (a)
OneToOne
MSN5 39
thale cress
(Arabidopsis thaliana)
eudicotyledons HST 36
  • 39.99 (n)
  • 26.68 (a)
rice
(Oryza sativa)
Liliopsida Os01g0363900 36
  • 38.62 (n)
  • 25.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToOne
Species with no ortholog for XPO5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XPO5 Gene

ENSEMBL:
Gene Tree for XPO5 (if available)
TreeFam:
Gene Tree for XPO5 (if available)

Paralogs for XPO5 Gene

No data available for Paralogs for XPO5 Gene

Variants for XPO5 Gene

Sequence variations from dbSNP and Humsavar for XPO5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs699937 -- 43,573,189(-) GCCCT(C/T)GAAGC intron-variant
rs832393 -- 43,532,375(-) AGCCC(A/G)GCTGT intron-variant
rs1096642 -- 43,537,936(-) tgtgc(A/G)ccacc intron-variant
rs1096643 -- 43,537,898(-) gtaga(G/T)acagg intron-variant
rs1096699 -- 43,560,704(-) ATTCT(A/G)ATTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPO5 Gene

Variant ID Type Subtype PubMed ID
nsv818414 CNV Gain 17921354
dgv6842n71 CNV Loss 21882294

Relevant External Links for XPO5 Gene

HapMap Linkage Disequilibrium report
XPO5
Human Gene Mutation Database (HGMD)
XPO5

Disorders for XPO5 Gene

(1) University of Copenhagen DISEASES for XPO5 Gene

Relevant External Links for XPO5

Genetic Association Database (GAD)
XPO5
Human Genome Epidemiology (HuGE) Navigator
XPO5
genes like me logo Genes that share disorders with XPO5: view

No data available for UniProtKB/Swiss-Prot for XPO5 Gene

Publications for XPO5 Gene

  1. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PMID: 11777942) Brownawell A.M. … Macara I.G. (J. Cell Biol. 2002) 2 3 4 23
  2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PMID: 12426392) Bohnsack M.T. … Goerlich D. (EMBO J. 2002) 2 3 4 23
  3. Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PMID: 14570900) Gwizdek C. … Dargemont C. (J. Biol. Chem. 2004) 3 4 23
  4. Nuclear export of microRNA precursors. (PMID: 14631048) Lund E. … Kutay U. (Science 2004) 3 4 23
  5. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. (PMID: 14681208) Yi R. … Cullen B.R. (Genes Dev. 2003) 3 4 23

Products for XPO5 Gene

Sources for XPO5 Gene

Back to Top

Content