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XPO5 Gene

protein-coding   GIFtS: 64
GCID: GC06M043490

Exportin 5

  See XPO5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exportin 51 2     exportin-52
Ran-Binding Protein 212 3     Exp53
KIAA12913 5     RANBP213
exp52     

External Ids:    HGNC: 176751   Entrez Gene: 575102   Ensembl: ENSG000001245717   OMIM: 6078455   UniProtKB: Q9HAV43   

Export aliases for XPO5 gene to outside databases

Previous GC identifers: GC06M043492 GC06M043536 GC06M043598 GC06M043209


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XPO5 Gene:
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and
double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo
through the nuclear pore complex in a RanGTP-dependent process. (provided by RefSeq, Aug 2011)

GeneCards Summary for XPO5 Gene:
XPO5 (exportin 5) is a protein-coding gene. Diseases associated with XPO5 include pleuropulmonary blastoma, and blastoma. GO annotations related to this gene include RNA binding and tRNA binding.

UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4
Function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and
double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its
active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA.
Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon
transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and
RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5
then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round
of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of
the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances
enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a
RanGTP-dependent manner
Function: Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the
nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some
circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes
dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a
double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

Gene Wiki entry for XPO5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the XPO5 gene promoter:
         Elk-1   RP58   Bach2   CUTL1   Nkx2-5   POU3F2   PPAR-gamma1   c-Myb   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPO5 promoter sequence
   Search Chromatin IP Primers for XPO5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XPO5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

XPO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M043490:  view genomic region     (about GC identifiers)

Start:
43,490,068 bp from pter      End:
43,543,812 bp from pter
Size:
53,745 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4 (See protein sequence)
Recommended Name: Exportin-5  
Size: 1204 amino acids; 136311 Da
Subunit: Component of a nuclear export receptor complex composed of XPO5, Ran, dsRNA-binding proteins and dsRNA.
Found in a nuclear export complex with XPO5, Ran, EEF1A1, and aminoacylated tRNA. Found in a nuclear export
complex with XPO5, Ran, ILF3 and dsRNA. Found in a nuclear export complex with XPO5, Ran and pre-miRNA. Found in
a nuclear export complex with XPO5, Ran, ILF3 and minihelix VA1 dsRNA. Found in a nuclear export complex with
XPO5, RAN, ILF3, ZNF346 and dsRNA. Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346. Interacts with Ran and
cargo proteins in a GTP-dependent manner. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM domains)
Sequence caution: Sequence=AAH00129.1; Type=Erroneous initiation; Sequence=BAA86605.2; Type=Erroneous initiation;
Sequence=BAA91547.1; Type=Frameshift; Positions=920; Sequence=CAI42640.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for XPO5:
3A6P (3D)    
Secondary accessions: Q5JTE6 Q96G48 Q96HN3 Q9BWM6 Q9BZV5 Q9H9M4 Q9NT89 Q9NW39 Q9ULC9

Explore the universe of human proteins at neXtProt for XPO5: NX_Q9HAV4

Explore proteomics data for XPO5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys216, Lys396, Lys930, Lys1140, Lys1173, Lys1180
  • Modification sites at PhosphoSitePlus

  • See XPO5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065801.1  
    ENSEMBL proteins: 
     ENSP00000265351   ENSP00000426185   ENSP00000387384   ENSP00000381816   ENSP00000424196  
     ENSP00000381779  
    Reactome Protein details: Q9HAV4

    XPO5 Human Recombinant Protein Products:

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    Novus Biologicals XPO5 Protein
    Novus Biologicals XPO5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XPO5

     
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    XPO5 Antibody Products:

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    Abcam antibodies for XPO5
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    LSBio Antibodies in human, mouse, rat for XPO5

    XPO5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for XPO5
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    Search eBioscience for ELISAs for XPO5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    XPO: Exportins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9HAV4

    ProtoNet protein and cluster: Q9HAV4

    UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4
    Similarity: Belongs to the exportin family


    Find genes that share domains with XPO5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPO5_HUMAN, Q9HAV4
    Function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and
    double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its
    active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA.
    Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon
    transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and
    RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5
    then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round
    of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of
    the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances
    enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a
    RanGTP-dependent manner
    Function: Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the
    nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some
    circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes
    dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a
    double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0003723RNA binding TAS--
    GO:0005488binding ----
    GO:0005515protein binding IPI19124606
    GO:0008536Ran GTPase binding IEA--
         
    Find genes that share ontologies with XPO5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for XPO5:
     Increased G1 DNA content  Increased gamma-H2AX phosphory  Nuclear 60S biogenesis defects 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XPO5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XPO5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XPO5

    miRNA
    Products:
        
    miRTarBase miRNAs that target XPO5:
    hsa-mir-425-3p (MIRT042432), hsa-mir-92b-3p (MIRT040694), hsa-let-7b-5p (MIRT032236)

    Block miRNA regulation of human, mouse, rat XPO5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate XPO5 (see all 44):
    hsa-miR-576-3p hsa-miR-100* hsa-miR-513a-5p hsa-miR-29a hsa-miR-218 hsa-miR-766 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidXPO5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for XPO5
    Predesigned siRNA for gene silencing in human, mouse, rat XPO5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for XPO5

    Clone
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    GenScript: all cDNA clones in your preferred vector: XPO5 (NM_020750)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO5
    Addgene plasmids for XPO5 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for XPO5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XPO5_HUMAN, Q9HAV4: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with XPO5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XPO5 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulatory RNA pathways
    Regulatory RNA pathways0.88
    MicroRNA (miRNA) Biogenesis0.88
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control
    4RNA transport
    RNA transport


    Find genes that share SuperPaths with XPO5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for XPO5
        Translational Control

    1 Reactome Pathway for XPO5
        MicroRNA (miRNA) biogenesis


    1 Kegg Pathway  (Kegg details for XPO5):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XPO5
    Interactions:

        GeneGlobe Interaction Network for XPO5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for XPO5 (Q9HAV42, 3 ENSP000002653514) via UniProtKB, MINT, STRING, and/or I2D (see all 734)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681042, 3, ENSP000003300544MINT-7947479 I2D: score=4 STRING: ENSP00000330054
    SMAD4Q134852, 3, ENSP000003415514MINT-61964 I2D: score=3 STRING: ENSP00000341551
    RBBP5Q152912, 3, ENSP000002645154MINT-7947479 I2D: score=1 STRING: ENSP00000264515
    ACTBP607092, 3MINT-7947479 I2D: score=2 
    DNAJA1P316892, 3MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006611protein export from nucleus IEA--
    GO:0006886intracellular protein transport ----
    GO:0010467gene expression TAS--
    GO:0031047gene silencing by RNA IEA--

    Find genes that share ontologies with XPO5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XPO5

    1 HMDB Compound for XPO5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for XPO5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna 41.5 2 16963774 (1)



    Find genes that share compounds with XPO5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XPO5 gene: 
    NM_020750.2  

    Unigene Cluster for XPO5:

    Exportin 5
    Hs.203206  [show with all ESTs]
    Unigene Representative Sequence: NM_020750
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265351(uc003ovp.3) ENST00000455854 ENST00000488195 ENST00000486936
    ENST00000455285 ENST00000450462 ENST00000398835 ENST00000515657 ENST00000513451
    ENST00000496341 ENST00000424378 ENST00000398799
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate XPO5 (see all 44):
    hsa-miR-576-3p hsa-miR-100* hsa-miR-513a-5p hsa-miR-29a hsa-miR-218 hsa-miR-766 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidXPO5 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: XPO5 (NM_020750)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO5
    Addgene plasmids for XPO5 
    Primer
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    OriGene qPCR primer pairs and template standards for XPO5
    OriGene qSTAR qPCR primer pairs in human, mouse for XPO5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XPO5
      QuantiTect SYBR Green Assays in human, mouse, rat XPO5
      QuantiFast Probe-based Assays in human, mouse, rat XPO5

    Additional mRNA sequence: 

    AB033117.2 AF271159.1 AF298880.1 AK001195.1 AK022718.1 AK023431.1 AK024301.1 AK025864.1 
    AK127513.1 AK291452.1 AL137467.1 AL834207.1 BC000129.1 BC008347.1 BC009969.2 BC062635.1 

    Selected DOTS entries (see all 25):

    DT.101970772  DT.100811606  DT.117479  DT.100811608  DT.99995909  DT.99997262  DT.121405758  DT.91659446 
    DT.121405494  DT.101980818  DT.121405378  DT.100037823  DT.121405666  DT.100811605  DT.121405328  DT.40269817 
    DT.92447587  DT.92447592  DT.92447595  DT.100811609  DT.75131516  DT.75157158  DT.92447588  DT.92447594 

    Selected AceView cDNA sequences (see all 327):

    BQ012406 BE220554 AI625092 AI686140 AW135759 AU125578 BM706285 AF271159 
    T08016 AL834207 AU125748 AB033117 BQ069282 Z42729 Z38885 BQ053097 
    BM127692 BM826842 BM829018 CA419664 CB122399 BQ673134 BC009969 AA877275 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    XPO5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTAAAAA
    XPO5 Expression
    About this image


    XPO5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    XPO5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XPO5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203206

    UniProtKB/Swiss-Prot: XPO5_HUMAN, Q9HAV4
    Tissue specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas

        Custom PCR Arrays for XPO5
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    QuantiFast Probe-based Assays in human, mouse, rat XPO5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPO5 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpo51 , 5 exportin 51, 5 86.52(n)1
    87.71(a)1
      17 (22.90 cM)5
    723221  NM_028198.21  NP_082474.11 
     462028555 
    chicken
    (Gallus gallus)
    Aves XPO51 exportin 5 76.74(n)
    83.89(a)
      421450  NM_001277652.1  NP_001264581.1 
    lizard
    (Anolis carolinensis)
    Reptilia XPO56
    exportin 5
    80(a)
    1 ↔ 1
    1(230969708-231021048)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ884365.12   -- 85.71(n)    BQ884365.1 
    zebrafish
    (Danio rerio)
    Actinopterygii xpo51 exportin 5 63.74(n)
    60.81(a)
      558662  XM_001921387.4  XP_001921422.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ranbp211 , 3 RAN protein binding3
    Ranbp211
    35(a)3
    47.21(n)1
    37.55(a)1
      329701  NM_134495.21  NP_608339.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSN5(YDR335W)4 Karyopherin involved in nuclear import and export of more   --   4(1141168-1144842) 851935  NP_010622.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HST1 HST 39.99(n)
    26.68(a)
      819666  NM_111376.3  NP_187155.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g03639001 Os01g0363900 38.62(n)
    25.38(a)
      4325820  NM_001049569.1  NP_001043034.1 


    ENSEMBL Gene Tree for XPO5 (if available)
    TreeFam Gene Tree for XPO5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for XPO5 (see all 1152)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018731371,2
    Cuntested143516084(+) TTAAAA/G/TTGGTT 2 Q H mis11EU 569
    rs596613011,2
    C--43244783(+) AAAAA-/A/AA  
            
    GGAGG
    1 -- int11NA 2
    rs38302121,2
    C--43409737(-) TCTGT-/GTTTCTA 1 -- int10--------
    rs1858604291,2
    --43489830(+) CAGTAA/GCAATT 1 -- int10--------
    rs1409454871,2
    C--43489854(+) CCCAG-/CAGC  
            
    CACAC
    1 -- int10--------
    rs758343371,2
    C,F--43489994(+) TGTTTT/CAGTCC 1 -- int11Minor allele frequency- C:0.02WA 118
    rs31771641,2
    C--43490075(-) GTACAG/AAAAGG 1 -- ut31 ese31Minor allele frequency- A:0.00NA 2
    rs1904897461,2
    --43490081(+) TGTACA/GAAACT 1 -- ut310--------
    rs1441280301,2
    C--43490198(+) TTACAA/GTGCAA 1 -- ut310--------
    rs1830565141,2
    --43490369(+) CTTTGA/CTTCTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for XPO5 (43490068 - 43543812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for XPO5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6842n71CNV Loss21882294
    nsv818414CNV Gain17921354

    Human Gene Mutation Database (HGMD): XPO5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XPO5
    DNA2.0 Custom Variant and Variant Library Synthesis for XPO5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607845    OMIM disorders: --

    2 diseases for XPO5:    
    About MalaCards
    pleuropulmonary blastoma    blastoma

    1 disease from the University of Copenhagen DISEASES database for XPO5:
    Pleuropulmonary blastoma

    Find genes that share disorders with XPO5           About GenesLikeMe

    Genetic Association Database (GAD): XPO5
    Human Genome Epidemiology (HuGE) Navigator: XPO5 (8 documents)

    Export disorders for XPO5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XPO5 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with XPO5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)1, 2, 3, 9 Brownawell A.M. and Macara I.G. (J. Cell Biol. 2002)
    2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PubMed id 12426392)1, 2, 3, 9 Bohnsack M.T.... Goerlich D. (EMBO J. 2002)
    3. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PubMed id 15254228)1, 2, 9 Chen T.... Macara I.G. (Mol. Cell. Biol. 2004)
    4. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. (PubMed id 15613540)1, 2, 9 Yi R.... Cullen B.R. (RNA 2005)
    5. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. (PubMed id 14681208)1, 2, 9 Yi R.... Cullen B.R. (Genes Dev. 2003)
    6. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. (PubMed id 14730017)1, 2, 9 Bohnsack M.T.... Goerlich D. (RNA 2004)
    7. Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PubMed id 14570900)1, 2, 9 Gwizdek C....Dargemont C. (J. Biol. Chem. 2004)
    8. RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PubMed id 19124606)1, 2, 9 Fritz J....Jantsch M.F. (Mol. Cell. Biol. 2009)
    9. Nuclear export of microRNA precursors. (PubMed id 14631048)1, 2, 9 Lund E.... Kutay U. (Science 2004)
    10. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57510 HGNC: 17675 AceView: XPO5 Ensembl:ENSG00000124571 euGenes: HUgn57510
    ECgene: XPO5 Kegg: 57510 H-InvDB: XPO5

    (According to HUGE)
    About This Section

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    HUGE: KIAA1291

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for XPO5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XPO5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for XPO5 gene:
    Search GeneIP for patents involving XPO5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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