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Aliases for XPO4 Gene

Aliases for XPO4 Gene

  • Exportin 4 2 3
  • Exp4 3 4
  • Exportin-4 3
  • KIAA1721 4

External Ids for XPO4 Gene

Previous GeneCards Identifiers for XPO4 Gene

  • GC13M019333
  • GC13M015333
  • GC13M020283
  • GC13M019155
  • GC13M019151
  • GC13M020252
  • GC13M021351
  • GC13M002154

Summaries for XPO4 Gene

Entrez Gene Summary for XPO4 Gene

  • XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

GeneCards Summary for XPO4 Gene

XPO4 (Exportin 4) is a Protein Coding gene. Diseases associated with XPO4 include pinguecula. Among its related pathways are Ran Pathway.

UniProtKB/Swiss-Prot for XPO4 Gene

  • Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for XPO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO4 Gene

Genomics for XPO4 Gene

Regulatory Elements for XPO4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for XPO4 Gene

Start:
20,777,329 bp from pter
End:
20,903,048 bp from pter
Size:
125,720 bases
Orientation:
Minus strand

Genomic View for XPO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XPO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO4 Gene

Proteins for XPO4 Gene

  • Protein details for XPO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0E2-XPO4_HUMAN
    Recommended name:
    Exportin-4
    Protein Accession:
    Q9C0E2
    Secondary Accessions:
    • Q5VUZ5
    • Q8N3V6
    • Q9H934

    Protein attributes for XPO4 Gene

    Size:
    1151 amino acids
    Molecular mass:
    130139 Da
    Quaternary structure:
    • Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner.
    SequenceCaution:
    • Sequence=BAB14409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for XPO4 Gene

Proteomics data for XPO4 Gene at MOPED

Post-translational modifications for XPO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XPO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XPO4 Gene

Domains for XPO4 Gene

Gene Families for XPO4 Gene

HGNC:
  • XPO :Exportins

Protein Domains for XPO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XPO4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0E2

UniProtKB/Swiss-Prot:

XPO4_HUMAN :
  • Q9C0E2
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO4: view

Function for XPO4 Gene

Molecular function for XPO4 Gene

UniProtKB/Swiss-Prot Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for XPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 10944119
genes like me logo Genes that share ontologies with XPO4: view

Phenotypes for XPO4 Gene

MGI mutant phenotypes for XPO4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with XPO4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XPO4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for XPO4 Gene

Localization for XPO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO4 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPO4 Gene COMPARTMENTS Subcellular localization image for XPO4 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for XPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with XPO4: view

Pathways for XPO4 Gene

SuperPathways for XPO4 Gene

Superpath Contained pathways
1 Ran Pathway
genes like me logo Genes that share pathways with XPO4: view

Pathways by source for XPO4 Gene

1 Qiagen pathway for XPO4 Gene

Gene Ontology (GO) - Biological Process for XPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0046827 positive regulation of protein export from nucleus IMP 16449645
genes like me logo Genes that share ontologies with XPO4: view

Compounds for XPO4 Gene

(1) HMDB Compounds for XPO4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with XPO4: view

Transcripts for XPO4 Gene

Unigene Clusters for XPO4 Gene

Exportin 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XPO4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for XPO4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: -
SP5: - -
SP6: - - -
SP7:

ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for XPO4 Gene

GeneLoc Exon Structure for
XPO4
ECgene alternative splicing isoforms for
XPO4

Expression for XPO4 Gene

mRNA expression in normal human tissues for XPO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XPO4 Gene

This gene is overexpressed in Muscle - Skeletal (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPO4 Gene

SOURCE GeneReport for Unigene cluster for XPO4 Gene Hs.507452

genes like me logo Genes that share expressions with XPO4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for XPO4 Gene

Orthologs for XPO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO4 35
  • 99.8 (n)
  • 100 (a)
XPO4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XPO4 35
  • 86.27 (n)
  • 96.52 (a)
XPO4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO4 35
  • 96.15 (n)
  • 99.74 (a)
XPO4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo4 35
  • 92.12 (n)
  • 98.52 (a)
Xpo4 16
Xpo4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPO4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Xpo4 35
  • 92.02 (n)
  • 98.26 (a)
chicken
(Gallus gallus)
Aves XPO4 35
  • 87.06 (n)
  • 95.74 (a)
XPO4 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPO4 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30830 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1741 35
xpo4 35
  • 80.38 (n)
  • 94.35 (a)
zebrafish
(Danio rerio)
Actinopterygii wufc26b07 35
xpo4 35
  • 74.32 (n)
  • 86.61 (a)
xpo4 36
  • 87 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y69A2AR.16 35
  • 40.48 (n)
  • 26.41 (a)
Y69A2AR.16 36
  • 26 (a)
OneToOne
Y69A2AR.16 37
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G04490 35
  • 43.42 (n)
  • 31.05 (a)
rice
(Oryza sativa)
Liliopsida Os10g0477000 35
  • 43.93 (n)
  • 31.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for XPO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO4 Gene

ENSEMBL:
Gene Tree for XPO4 (if available)
TreeFam:
Gene Tree for XPO4 (if available)

Paralogs for XPO4 Gene

No data available for Paralogs for XPO4 Gene

Variants for XPO4 Gene

Sequence variations from dbSNP and Humsavar for XPO4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs4044 -- 20,778,093(-) AAAAA(C/T)ACAAT utr-variant-3-prime
rs482211 -- 20,854,850(+) ACAAT(A/G)ACCCC intron-variant
rs499577 -- 20,850,265(+) GAGAC(A/G)GCACA intron-variant
rs509099 -- 20,879,599(-) agtgg(C/T)ttatt intron-variant
rs513795 -- 20,853,309(+) GACTG(C/T)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPO4 Gene

Variant ID Type Subtype PubMed ID
nsv951 CNV Insertion 18451855
nsv483010 CNV Complex 15286789

Relevant External Links for XPO4 Gene

HapMap Linkage Disequilibrium report
XPO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO4 Gene

Disorders for XPO4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for XPO4 Gene including...

Search for XPO4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for XPO4 Gene

Relevant External Links for XPO4

Genetic Association Database (GAD)
XPO4
Human Genome Epidemiology (HuGE) Navigator
XPO4
genes like me logo Genes that share disorders with XPO4: view

No data available for UniProtKB/Swiss-Prot for XPO4 Gene

Publications for XPO4 Gene

  1. The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. (PMID: 16449645) Kurisaki A. … Moustakas A. (Mol. Cell. Biol. 2006) 3 4 23
  2. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. (PMID: 10944119) Lipowsky G. … Goerlich D. (EMBO J. 2000) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4

Products for XPO4 Gene

Sources for XPO4 Gene

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