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Aliases &
Descriptions
for XPO4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| Exp4 3 | | FLJ13046 1, 2 | | KIAA1721 1, 2, 3 | | OTTHUMP00000018105 2 |
| | |
| |
Search outside databases for aliases for XPO4 genePrevious GC identifers: GC13M019333 GC13M015333 GC13M020283 GC13M019155 GC13M019151 |
Summaries
for XPO4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for XPO4:
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of
proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000
[PubMed 10944119]).[supplied by OMIM]
UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the
nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form.
Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to
nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the
complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause
release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and
mediate another round of transport. The directionality of nuclear export is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
cytoplasm and nucleusGene Wiki entry for XPO4 |
Genomic Location
for XPO4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the XPO4 gene 
Entrez Gene cytogenetic band: 13q11 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q11XPO4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M020252:
(about GC identifiers)
Start:
|
20,249,468 bp from pter |
End:
|
20,374,949 bp from pter |
Size:
|
125,482 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000013.9 NT_024524.13
| Proteins
for XPO4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2 (See
protein sequence)Recommended Name: Exportin-4 Size: 1151 amino acids; 130139 Da
Subunit: Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3.
Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
Secondary accessions: Q5VUZ5 Q8N3V6 Q9H934Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_071904.4
ENSEMBL proteins: ENSP00000255305 ENSP00000383444
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for XPO4:
Assays for XPO4: | Protein
Domains/
Families
for XPO4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9C0E2 UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2Similarity: Belongs to the exportin family | Gene Function
for XPO4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022459
 Applied Biosystems Silencer® siRNAs for XPO4
 Sigma-Aldrich siRNA for XPO4
Sigma-Aldrich shRNA for XPO4
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_022459
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022459
untagged cDNA clones in CMV expression vector (see all 2): NM_022459
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_022459
UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the
nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form.
Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to
nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the
complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause
release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and
mediate another round of transport. The directionality of nuclear export is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
cytoplasm and nucleus1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions
for XPO4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/7 Interacting proteins for XPO4 (ENSP000002553053 Q9C0E21) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- |
About this table
|
Drugs & Compounds
for XPO4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for XPO4
|
Transcripts
for XPO4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022459
Sigma-Aldrich siRNA for XPO4
Sigma-Aldrich shRNA for XPO4
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_022459 REFSEQ mRNAs for XPO4 gene: NM_022459.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_022459
OriGene GFP tagged cDNA clone in CMV expression vector: NM_022459
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022459
untagged cDNA clones in CMV expression vector (see all 2): NM_022459
Additional cDNA sequence: AB051508.1 AK023108.1 AK057924.1 AK302760.1 AL831819.2 BC042504.1 BC050680.1 BC098402.1 BC113571.1 BC113573.1 BX647843.1 15 DOTS entries: DT.85105629 DT.100691259 DT.40294490 DT.100788432 DT.101149 DT.91832009 DT.91652526 DT.91853064 DT.100788437 DT.101980017 DT.120784604 DT.120784639 DT.120784642 DT.120784647 DT.91864191 24/172 AceView cDNA sequences (see all 172
):CD677729 BQ227865 BG060130 BU187727 AI475135 AL118883 BP872340 BX111551 AI859878 AK057924 T95334 AI478371 CD365633 AW188254 C00232 BF574405 BU195597 AB051508 BC042504 AA283130 BQ217218 AI955893 CA428915 AW152324
 highest scoring ESTs for XPO4:AA348215 AA737176 AA993090 AB051508 AK057924 AL118883 BC050680 BU187727 CD657679 CF593754 Unigene Cluster for XPO4: Exportin 4 Hs.507452 [show with all ESTs]Unigene Representative Sequence: NM_022459
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for XPO4 (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for XPO4
2 Ensembl transcripts including schematic representations: ENST00000255305
ENST00000400602
|
Expression
for XPO4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| XPO4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for XPO4
1 / 2 / 3 9 probe-sets matching XPO4 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACATAGTTAA
SOURCE GeneReport for Unigene cluster: Hs.507452
|
Orthologs
for XPO4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XPO4 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for XPO4
ENSEMBL Gene Tree for XPO4 | Paralogs
for XPO4(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for XPO4 gene
- RANBP172 XPO72
|
SNPs/Variants
for XPO4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for XPO4 (up to first 250kb)
|
Disorders & Mutations
for XPO4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611449
Human Genome Epidemiology Navigator: XPO4 (1 document)
|
Medical News
for XPO4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for XPO4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for XPO4 gene (see all 15
):- Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. (PubMed id 10944119)2, 3, 4 Lipowsky G....Gorlich D. (2000)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)2, 3, 4 Nagase T....Ohara O. (2000)
- The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. (PubMed id 16449645)1, 3, 4 Kurisaki A.... Moustakas A. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)3, 4 Dunham A.... Ross M.T. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)3 Trynka G....Wijmenga C. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
|
Search for XPO4
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing XPO4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing XPO4
(According to HUGE)
About This Section
| |
Specialized Databases showing XPO4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for XPO4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for XPO4:
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