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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XPO4 Gene

protein-coding   GIFtS: 56
GCID: GC13M021351

Exportin 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Exportin 41 2
exp42
exportin-42
Exp43
KIAA17213

External Ids:    HGNC: 177961   Entrez Gene: 643282   Ensembl: ENSG000001329537   OMIM: 6114495   UniProtKB: Q9C0E23   

Export aliases for XPO4 gene to outside databases

Previous GC identifers: GC13M019333 GC13M015333 GC13M020283 GC13M019155 GC13M019151 GC13M020252 GC13M002154


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XPO4 Gene:
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other
cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 (PubMed 10944119)).(supplied by
OMIM, Mar 2009)

GeneCards Summary for XPO4 Gene: 
XPO4 (exportin 4) is a protein-coding gene. Diseases associated with XPO4 include pinguecula, and hyperphosphatemia. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2
Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds
cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex
to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export
complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1
and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear
compartment and mediate another round of transport. The directionality of nuclear export is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Gene Wiki entry for XPO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XPO4 gene promoter:
         Spz1   CUTL1   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   E2F-1   E2F   LyF-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPO4 promoter sequence
   Search SABiosciences Chromatin IP Primers for XPO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11

XPO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M021351:  view genomic region     (about GC identifiers)

Start:
21,351,468 bp from pter      End:
21,477,187 bp from pter
Size:
125,720 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2 (See protein sequence)
Recommended Name: Exportin-4  
Size: 1151 amino acids; 130139 Da
Subunit: Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with
SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
Sequence caution: Sequence=BAB14409.1; Type=Erroneous initiation;
Secondary accessions: Q5VUZ5 Q8N3V6 Q9H934

Explore the universe of human proteins at neXtProt for XPO4: NX_Q9C0E2

Explore proteomics data for XPO4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C0E2

  • XPO4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    XPO4 Protein Expression
    REFSEQ proteins: NP_071904.4  
    ENSEMBL proteins: 
     ENSP00000255305   ENSP00000383444  

    Human Recombinant Protein Products for XPO4: 
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    OriGene Custom Protein Services for XPO4
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XPO4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    XPO4 for ontologies           About GeneDecksing



    XPO4 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for XPO4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    XPO: Exportins

    2 InterPro protein domains:
     IPR014877 CRM1_C_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9C0E2

    ProtoNet protein and cluster: Q9C0E2

    UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2
    Similarity: Belongs to the exportin family


    XPO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPO4_HUMAN, Q9C0E2
    Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds
    cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex
    to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export
    complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1
    and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear
    compartment and mediate another round of transport. The directionality of nuclear export is thought to be
    conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI10944119
         
    XPO4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Xpo4):
     normal 

    XPO4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for XPO4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XPO4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XPO4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XPO4 

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for XPO4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ran Pathway
    Ran Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for XPO4
        Ran Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XPO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for XPO4 (Q9C0E23 ENSP000002553054) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF2Q9HAW03, ENSP000002206594I2D: score=2 STRING: ENSP00000220659
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=2 STRING: ENSP00000356278
    EIF5AP632413, ENSP000003367024I2D: score=1 STRING: ENSP00000336702
    RANP628263, ENSP000003961274I2D: score=1 STRING: ENSP00000396127
    SOX2P484313, ENSP000003235884I2D: score=1 STRING: ENSP00000323588
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0046827positive regulation of protein export from nucleus IMP16449645

    XPO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XPO4

    1 HMDB Compound for XPO4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about XPO4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for XPO4 gene: 
    NM_022459.4  

    Unigene Cluster for XPO4:

    Exportin 4
    Hs.507452  [show with all ESTs]
    Unigene Representative Sequence: NM_022459
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255305(uc010tcr.1) ENST00000490513 ENST00000465018 ENST00000400602(uc001unq.4)

    miRNA
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    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate XPO4 (see all 117):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-3122 hsa-miR-4274 hsa-miR-298 hsa-miR-4325 hsa-miR-3649
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for XPO4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XPO4
    Clone
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    OriGene ORF clones in mouse, rat for XPO4
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    GenScript: all cDNA clones in your preferred vector: XPO4 (NM_022459)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO4
    Sirion Biotech Customized lentivirus for stable overexpression of XPO4 
                         Customized lentivirus expression plasmids for stable overexpression of XPO4 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for XPO4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XPO4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPO4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPO4

    Additional mRNA sequence: 

    AB051508.1 AK023108.1 AK057924.1 AK302760.1 AL831819.2 BC042504.1 BC050680.1 BC098402.1 
    BC113571.1 BC113573.1 BX647843.1 

    15 DOTS entries:

    DT.85105629  DT.100691259  DT.40294490  DT.100788432  DT.101149  DT.91832009  DT.91652526  DT.91853064 
    DT.100788437  DT.101980017  DT.120784604  DT.120784639  DT.120784642  DT.120784647  DT.91864191 

    24/172 AceView cDNA sequences (see all 172):

    AI859878 BF574405 T95334 BU187727 AB051508 BX111551 AA283130 CB068614 
    AI955893 BQ217218 AA418191 AW152324 AK057924 AL118883 AA282922 BU170608 
    T52973 NM_022459 AW188254 CD677729 AA737176 BC042504 CA428915 CD365633 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for XPO4 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                    -     -           -     -                                         -                                                                     
    SP2:                    -     -     -     -     -     -     -     -                       -                                                                     
    SP3:                                      -     -                                                                                                               
    SP4:                          -                                                                                                                                 
    SP5:                    -     -                                                                                                                                 

    ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for XPO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XPO4 expression in normal human tissues (normalized intensities)      XPO4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATAGTTAA
    XPO4 Expression
    About this image


    XPO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             deltoid muscle   
     
     Bone (Muscoskeletal System)
             mandibular prominence tissue e10.0   
     
     Head Mesenchyme (Muscoskeletal System)
             mandibular prominence tissue e10.0   
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord

    See XPO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XPO4

    SOURCE GeneReport for Unigene cluster: Hs.507452
        SABiosciences Custom PCR Arrays for XPO4
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPO4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPO4 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpo41 , 5 exportin 41, 5 92.12(n)1
    98.52(a)1
      14 (30.11 cM)5
    572581  NM_020506.11  NP_065252.11 
     575810025 
    chicken
    (Gallus gallus)
    Aves XPO41 exportin 4 87.06(n)
    95.74(a)
      428081  NM_001012947.1  NP_001012965.1 
    lizard
    (Anolis carolinensis)
    Reptilia XPO46
    Uncharacterized protein
    95(a)
    1 ↔ 1
    3(187560853-187637136)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.308302 Xenopus laevis transcribed sequence with moderate similarity more 81.28(n)    48039105 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc26b072 Danio rerio similar to Exportin 4, mRNA (cDNA clone more 77.22(n)    BC048882.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y69A2AR.163
    CELE_Y69A2AR.161
    Protein Y69A2AR.161 22(a)3
    40.37(n)1
    26.15(a)1
      IV(2504343-2530111)3
    1770391  NM_067815.21  NP_500216.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G044901 hypothetical protein 42.82(n)
    29.72(a)
      819605  NM_111320.6  NP_187099.6 
    rice
    (Oryza sativa)
    Liliopsida Os10g04770001 hypothetical protein 43.58(n)
    30.28(a)
      4348897  NM_001071388.1  NP_001064853.1 


    ENSEMBL Gene Tree for XPO4 (if available)
    TreeFam Gene Tree for XPO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2469 SNPs in XPO4 are shown (see all 2469)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105896071,2
    C--2242375(+) ttttt-/T/TT  
            
    gagat
    1 -- int11NA 2
    rs1180254871,2
    C,F--21351094(+) TCTCTC/TGCCAC 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1888461981,2
    --21351116(+) GGCTTA/GCTTGC 1 -- ds50010--------
    rs752253281,2
    F--21351224(+) TAGTTG/CAATTA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs353360001,2
    C--21351275(+) TTCTC-/A/ATT 
            
    TTTTA
    1 -- ds50010--------
    rs1926850591,2
    --21351282(+) TTTTTA/TAAAAA 1 -- ds50010--------
    rs1846664121,2
    --21351412(+) TAGGTA/GTCAGA 1 -- ds50010--------
    rs1892069951,2
    --21351528(+) ACTTTA/TAAATT 1 -- ut310--------
    rs1406811261,2
    C--21351622(+) AGACAC/TTGAAT 1 -- ut310--------
    rs771374351,2
    C,F--21351730(+) CAGGTG/ATACAA 1 -- ut312Minor allele frequency- A:0.11WA NA 238

    HapMap Linkage Disequilibrium report for XPO4 (21351468 - 21477187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for XPO4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv951CNV Insertion18451855
    nsv483010CNV Complex15286789

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611449    OMIM disorders: --

    4 diseases for XPO4:    About MalaCards
    pinguecula    hyperphosphatemia    renal osteodystrophy    hepatocellular carcinoma

    2 diseases from the University of Copenhagen DISEASES database for XPO4:
    Pinguecula     Hyperphosphatemia

    XPO4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): XPO4
    Human Genome Epidemiology (HuGE) Navigator: XPO4 (1 document)

    Export disorders for XPO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XPO4 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with XPO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. (PubMed id 10944119)1, 2, 3 Lipowsky G.... Goerlich D. (2000)
    3. The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. (PubMed id 16449645)1, 2, 9 Kurisaki A.... Moustakas A. (2006)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64328 HGNC: 17796 AceView: XPO4 Ensembl:ENSG00000132953 euGenes: HUgn64328
    ECgene: XPO4 H-InvDB: XPO4

    (According to HUGE)
    About This Section
    HUGE: KIAA1721

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XPO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for XPO4 gene:
    Search GeneIP for patents involving XPO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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