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Aliases for XPO4 Gene

Aliases for XPO4 Gene

  • Exportin 4 2 3 5
  • Exp4 3 4
  • Exportin-4 3
  • KIAA1721 4

External Ids for XPO4 Gene

Previous GeneCards Identifiers for XPO4 Gene

  • GC13M019333
  • GC13M015333
  • GC13M020283
  • GC13M019155
  • GC13M019151
  • GC13M020252
  • GC13M021351
  • GC13M002154

Summaries for XPO4 Gene

Entrez Gene Summary for XPO4 Gene

  • XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

GeneCards Summary for XPO4 Gene

XPO4 (Exportin 4) is a Protein Coding gene. Diseases associated with XPO4 include Conjunctival Degeneration and Pinguecula. Among its related pathways are Ran Pathway and eIF5A regulation in response to inhibition of the nuclear export system. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for XPO4 Gene

  • Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for XPO4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO4 Gene

Genomics for XPO4 Gene

Regulatory Elements for XPO4 Gene

Enhancers for XPO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G020942 1.4 FANTOM5 Ensembl ENCODE 11.9 -40.6 -40560 1.3 ARID4B FEZF1 ZNF2 ZBTB40 RAD21 YY1 HSF1 ZSCAN5C ZNF143 FOS XPO4 LATS2-AS1 LATS2 LINC00367 CNOT4P1
GH13G020712 1.1 Ensembl ENCODE 11.6 +188.8 188753 3.5 ARID4B ZNF2 ZNF48 ZBTB7B RAD21 ZNF366 ZNF143 FOS U2AF2 THAP11 SLC35E1P1 IFT88 XPO4 EEF1AKMT1 CRYL1 ENSG00000279135 GC13M020722
GH13G020797 0.8 ENCODE dbSUPER 11.8 +105.1 105116 1.5 PKNOX1 ZNF692 ATF2 SPI1 EEF1AKMT1 CRYL1 XPO4 GC13P020892
GH13G020708 0.8 Ensembl ENCODE 11.6 +193.8 193766 1.7 GATAD2A GATA2 JUN CEBPB FOS ATF2 YY1 IFT88 XPO4 EEF1AKMT1 SLC35E1P1 CRYL1 ENSG00000279135 GC13M020702 ENSG00000278291
GH13G020506 0.8 ENCODE 10.6 +396.9 396852 0.2 ATF1 ZBTB21 ARID4B MAX DMAP1 FEZF1 YY1 CTBP1 GATA2 NCOR1 XPO4 CRYL1 MIR4499
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XPO4 on UCSC Golden Path with GeneCards custom track

Promoters for XPO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059714 448 2001 HDGF ARNT CREB3L1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF263

Genomic Location for XPO4 Gene

Chromosome:
13
Start:
20,777,329 bp from pter
End:
20,903,048 bp from pter
Size:
125,720 bases
Orientation:
Minus strand

Genomic View for XPO4 Gene

Genes around XPO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO4 Gene

Proteins for XPO4 Gene

  • Protein details for XPO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0E2-XPO4_HUMAN
    Recommended name:
    Exportin-4
    Protein Accession:
    Q9C0E2
    Secondary Accessions:
    • Q5VUZ5
    • Q8N3V6
    • Q9H934

    Protein attributes for XPO4 Gene

    Size:
    1151 amino acids
    Molecular mass:
    130139 Da
    Quaternary structure:
    • Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner.
    SequenceCaution:
    • Sequence=BAB14409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for XPO4 Gene

Post-translational modifications for XPO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for XPO4 Gene

Domains & Families for XPO4 Gene

Gene Families for XPO4 Gene

Protein Domains for XPO4 Gene

Suggested Antigen Peptide Sequences for XPO4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0E2

UniProtKB/Swiss-Prot:

XPO4_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO4: view

Function for XPO4 Gene

Molecular function for XPO4 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for XPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005049 nuclear export signal receptor activity IBA --
GO:0005515 protein binding IPI 10944119
GO:0008536 Ran GTPase binding IBA --
genes like me logo Genes that share ontologies with XPO4: view
genes like me logo Genes that share phenotypes with XPO4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO4 Gene

Localization for XPO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO4 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPO4 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for XPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with XPO4: view

Pathways & Interactions for XPO4 Gene

genes like me logo Genes that share pathways with XPO4: view

Pathways by source for XPO4 Gene

1 Qiagen pathway for XPO4 Gene

Gene Ontology (GO) - Biological Process for XPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IEA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0046827 positive regulation of protein export from nucleus IMP 16449645
genes like me logo Genes that share ontologies with XPO4: view

No data available for SIGNOR curated interactions for XPO4 Gene

Drugs & Compounds for XPO4 Gene

(1) Drugs for XPO4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with XPO4: view

Transcripts for XPO4 Gene

Unigene Clusters for XPO4 Gene

Exportin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: -
SP5: - -
SP6: - - -
SP7:

ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for XPO4 Gene

GeneLoc Exon Structure for
XPO4
ECgene alternative splicing isoforms for
XPO4

Expression for XPO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XPO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XPO4 Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

Protein differential expression in normal tissues from HIPED for XPO4 Gene

This gene is overexpressed in Bone (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XPO4 Gene



Protein tissue co-expression partners for XPO4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XPO4 Gene:

XPO4

SOURCE GeneReport for Unigene cluster for XPO4 Gene:

Hs.507452

Evidence on tissue expression from TISSUES for XPO4 Gene

  • Nervous system(4.5)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with XPO4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO4 Gene

Orthologs for XPO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO4 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia XPO4 34 35
  • 96.15 (n)
oppossum
(Monodelphis domestica)
Mammalia XPO4 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo4 34 16 35
  • 92.12 (n)
rat
(Rattus norvegicus)
Mammalia Xpo4 34
  • 92.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia XPO4 34 35
  • 86.27 (n)
chicken
(Gallus gallus)
Aves XPO4 34 35
  • 87.06 (n)
lizard
(Anolis carolinensis)
Reptilia XPO4 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpo4 34
  • 80.38 (n)
Str.1741 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.30830 34
zebrafish
(Danio rerio)
Actinopterygii xpo4 34 35
  • 74.32 (n)
wufc26b07 34
worm
(Caenorhabditis elegans)
Secernentea CELE_Y69A2AR.16 34
  • 40.48 (n)
Y69A2AR.16 36 35
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G04490 34
  • 43.42 (n)
rice
(Oryza sativa)
Liliopsida Os10g0477000 34
  • 43.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for XPO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO4 Gene

ENSEMBL:
Gene Tree for XPO4 (if available)
TreeFam:
Gene Tree for XPO4 (if available)

Paralogs for XPO4 Gene

No data available for Paralogs for XPO4 Gene

Variants for XPO4 Gene

Sequence variations from dbSNP and Humsavar for XPO4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000008065 -- 20,893,883(+) TTGTT(-/G)CCCAG intron-variant
rs1000014578 -- 20,903,130(+) TCCAC(C/G)ACGCC upstream-variant-2KB
rs1000050154 -- 20,867,506(+) ATGGT(A/G)TCGTT intron-variant
rs1000093314 -- 20,857,582(+) ATTAG(C/T)CAGGC intron-variant, upstream-variant-2KB
rs1000153341 -- 20,868,483(+) TAATT(G/T)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPO4 Gene

Variant ID Type Subtype PubMed ID
dgv923n106 CNV tandem duplication 24896259
esv3631437 CNV loss 21293372
esv3892305 CNV loss 25118596
nsv1078303 OTHER inversion 25765185
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv951 CNV insertion 18451855

Variation tolerance for XPO4 Gene

Residual Variation Intolerance Score: 2.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XPO4 Gene

Human Gene Mutation Database (HGMD)
XPO4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO4 Gene

Disorders for XPO4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for XPO4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
conjunctival degeneration
pinguecula
- elite association - COSMIC cancer census association via MalaCards
Search XPO4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for XPO4

Genetic Association Database (GAD)
XPO4
Human Genome Epidemiology (HuGE) Navigator
XPO4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XPO4
genes like me logo Genes that share disorders with XPO4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPO4 Gene

Publications for XPO4 Gene

  1. The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. (PMID: 16449645) Kurisaki A. … Moustakas A. (Mol. Cell. Biol. 2006) 3 4 22 64
  2. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. (PMID: 10944119) Lipowsky G. … Goerlich D. (EMBO J. 2000) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for XPO4 Gene

Sources for XPO4 Gene

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