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XPO4 Gene

protein-coding   GIFtS: 56
GCID: GC13M021351

Exportin 4

  See XPO4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exportin 41 2
exp42
exportin-42
Exp43
KIAA17213

External Ids:    HGNC: 177961   Entrez Gene: 643282   Ensembl: ENSG000001329537   OMIM: 6114495   UniProtKB: Q9C0E23   

Export aliases for XPO4 gene to outside databases

Previous GC identifers: GC13M019333 GC13M015333 GC13M020283 GC13M019155 GC13M019151 GC13M020252 GC13M002154


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XPO4 Gene:
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other
cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 (PubMed 10944119)).(supplied by
OMIM, Mar 2009)

GeneCards Summary for XPO4 Gene:
XPO4 (exportin 4) is a protein-coding gene. Diseases associated with XPO4 include pinguecula.

UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2
Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds
cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex
to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export
complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1
and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear
compartment and mediate another round of transport. The directionality of nuclear export is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Gene Wiki entry for XPO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the XPO4 gene promoter:
         Spz1   CUTL1   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   E2F-1   E2F   LyF-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPO4 promoter sequence
   Search Chromatin IP Primers for XPO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XPO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11

XPO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M021351:  view genomic region     (about GC identifiers)

Start:
21,351,468 bp from pter      End:
21,477,187 bp from pter
Size:
125,720 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2 (See protein sequence)
Recommended Name: Exportin-4  
Size: 1151 amino acids; 130139 Da
Subunit: Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with
SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner
Sequence caution: Sequence=BAB14409.1; Type=Erroneous initiation;
Secondary accessions: Q5VUZ5 Q8N3V6 Q9H934

Explore the universe of human proteins at neXtProt for XPO4: NX_Q9C0E2

Explore proteomics data for XPO4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See XPO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071904.4  
    ENSEMBL proteins: 
     ENSP00000255305   ENSP00000383444  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    XPO: Exportins

    2 InterPro protein domains:
     IPR014877 CRM1_C_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9C0E2

    ProtoNet protein and cluster: Q9C0E2

    UniProtKB/Swiss-Prot: XPO4_HUMAN, Q9C0E2
    Similarity: Belongs to the exportin family


    Find genes that share domains with XPO4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPO4_HUMAN, Q9C0E2
    Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds
    cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex
    to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export
    complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1
    and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear
    compartment and mediate another round of transport. The directionality of nuclear export is thought to be
    conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI10944119
         
    Find genes that share ontologies with XPO4           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Xpo4):
     normal 

    Find genes that share phenotypes with XPO4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XPO4
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    hsa-mir-18a-3p (MIRT040935), hsa-mir-877-3p (MIRT037079), hsa-mir-16-5p (MIRT051210), hsa-mir-146b-5p (MIRT041613), hsa-mir-98-5p (MIRT027480)

    Block miRNA regulation of human, mouse, rat XPO4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate XPO4 (see all 117):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-3122 hsa-miR-4274 hsa-miR-298 hsa-miR-4325 hsa-miR-3649
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XPO4_HUMAN, Q9C0E2: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with XPO4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XPO4 About    
    See pathways by source

    SuperPathContained pathways About
    1Ran Pathway
    Ran Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for XPO4
        Ran Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XPO4
    Interactions:

        Search GeneGlobe Interaction Network for XPO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for XPO4 (Q9C0E23 ENSP000002553054) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF2Q9HAW03, ENSP000002206594I2D: score=2 STRING: ENSP00000220659
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=2 STRING: ENSP00000356278
    EIF5AP632413, ENSP000003367024I2D: score=1 STRING: ENSP00000336702
    RANP628263, ENSP000003961274I2D: score=1 STRING: ENSP00000396127
    SOX2P484313, ENSP000003235884I2D: score=1 STRING: ENSP00000323588
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0046827positive regulation of protein export from nucleus IMP16449645

    Find genes that share ontologies with XPO4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XPO4

    1 HMDB Compound for XPO4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XPO4 gene: 
    NM_022459.4  

    Unigene Cluster for XPO4:

    Exportin 4
    Hs.507452  [show with all ESTs]
    Unigene Representative Sequence: NM_022459
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255305(uc010tcr.1) ENST00000490513 ENST00000465018 ENST00000400602(uc001unq.4)

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    Selected qRT-PCR Assays for microRNAs that regulate XPO4 (see all 117):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-3122 hsa-miR-4274 hsa-miR-298 hsa-miR-4325 hsa-miR-3649
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      QuantiFast Probe-based Assays in human, mouse, rat XPO4

    Additional mRNA sequence: 

    AB051508.1 AK023108.1 AK057924.1 AK302760.1 AL831819.2 BC042504.1 BC050680.1 BC098402.1 
    BC113571.1 BC113573.1 BX647843.1 

    15 DOTS entries:

    DT.85105629  DT.100691259  DT.40294490  DT.100788432  DT.101149  DT.91832009  DT.91652526  DT.91853064 
    DT.100788437  DT.101980017  DT.120784604  DT.120784639  DT.120784642  DT.120784647  DT.91864191 

    Selected AceView cDNA sequences (see all 172):

    AA283130 AW152324 AL118883 BU175911 T95334 AW188254 BF574405 C00232 
    CB068614 BU187727 BC042504 AA418191 BX111551 NM_022459 AI475135 BG060130 
    AA737176 AA927301 BU195597 AB051508 AA282922 CA428915 BU170608 AI478371 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for XPO4 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                    -     -           -     -                                         -                                                                     
    SP2:                    -     -     -     -     -     -     -     -                       -                                                                     
    SP3:                                      -     -                                                                                                               
    SP4:                          -                                                                                                                                 
    SP5:                    -     -                                                                                                                                 

    ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for XPO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XPO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATAGTTAA
    XPO4 Expression
    About this image


    XPO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Skeletal Muscle (Muscoskeletal System)
    XPO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XPO4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507452
        Custom PCR Arrays for XPO4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPO4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpo41 , 5 exportin 41, 5 92.12(n)1
    98.52(a)1
      14 (30.11 cM)5
    572581  NM_020506.11  NP_065252.11 
     575810025 
    chicken
    (Gallus gallus)
    Aves XPO41 exportin 4 87.06(n)
    95.74(a)
      428081  NM_001012947.1  NP_001012965.1 
    lizard
    (Anolis carolinensis)
    Reptilia XPO46
    exportin 4
    95(a)
    1 ↔ 1
    3(187560853-187637136)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.308302 Xenopus laevis transcribed sequence with moderate similarity more 81.28(n)    48039105 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc26b072 Danio rerio similar to Exportin 4, mRNA (cDNA clone more 77.22(n)    BC048882.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y69A2AR.163
    CELE_Y69A2AR.161
    CELE_Y69A2AR.161 22(a)3
    40.48(n)1
    26.41(a)1
      IV(2504343-2530111)3
    1770391  NM_067815.31  NP_500216.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G044901 AT3G04490 43.42(n)
    31.05(a)
      819605  NM_111320.6  NP_187099.6 
    rice
    (Oryza sativa)
    Liliopsida Os10g04770001 Os10g0477000 43.93(n)
    31.13(a)
      4348897  NM_001071388.1  NP_001064853.1 


    ENSEMBL Gene Tree for XPO4 (if available)
    TreeFam Gene Tree for XPO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for XPO4 (see all 2469)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105896071,2
    C--2242375(+) ttttt-/T/TT  
            
    gagat
    1 -- int11NA 2
    rs1180254871,2
    C,F--21351094(+) TCTCTC/TGCCAC 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1888461981,2
    --21351116(+) GGCTTA/GCTTGC 1 -- ds50010--------
    rs752253281,2
    F--21351224(+) TAGTTG/CAATTA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs353360001,2
    C--21351275(+) TTCTC-/A/ATT 
            
    TTTTA
    1 -- ds50010--------
    rs1926850591,2
    --21351282(+) TTTTTA/TAAAAA 1 -- ds50010--------
    rs1846664121,2
    --21351412(+) TAGGTA/GTCAGA 1 -- ds50010--------
    rs1892069951,2
    --21351528(+) ACTTTA/TAAATT 1 -- ut310--------
    rs1406811261,2
    C--21351622(+) AGACAC/TTGAAT 1 -- ut310--------
    rs771374351,2
    C,F--21351730(+) CAGGTG/ATACAA 1 -- ut312Minor allele frequency- A:0.11WA NA 238

    HapMap Linkage Disequilibrium report for XPO4 (21351468 - 21477187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for XPO4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv951CNV Insertion18451855
    nsv483010CNV Complex15286789

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611449    OMIM disorders: --

    1 disease for XPO4:    
    About MalaCards
    pinguecula

    2 diseases from the University of Copenhagen DISEASES database for XPO4:
    Pinguecula     Hyperphosphatemia

    Find genes that share disorders with XPO4           About GenesLikeMe

    Genetic Association Database (GAD): XPO4
    Human Genome Epidemiology (HuGE) Navigator: XPO4 (1 document)

    Export disorders for XPO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XPO4 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with XPO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. (PubMed id 10944119)1, 2, 3 Lipowsky G.... Goerlich D. (EMBO J. 2000)
    3. The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. (PubMed id 16449645)1, 2, 9 Kurisaki A.... Moustakas A. (Mol. Cell. Biol. 2006)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64328 HGNC: 17796 AceView: XPO4 Ensembl:ENSG00000132953 euGenes: HUgn64328
    ECgene: XPO4 H-InvDB: XPO4

    (According to HUGE)
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    HUGE: KIAA1721

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for XPO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for XPO4 gene:
    Search GeneIP for patents involving XPO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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