 |
 | Services
| |
 |
Aliases &
Descriptions
for XPO1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CRM1 1, 2, 3, 5 | | DKFZp686B1823 2 | | Exp1 3 |
| | | Descriptions |
|---|
| CRM1, yeast, homolog 2 | | Chromosome region maintenance 1 protein homolog 3 | | Exportin-1 (required for chromosome region maintenance) 2 | | exportin 1 2 | | exportin 1 (CRM1 homolog, yeast) 2 | | exportin 1 (CRM1, yeast, homolog) 1, 2 |
|
| |
Search outside databases for aliases for XPO1 genePrevious GC identifers: GC02M061833 GC02M061662 GC02M061679 |
Summaries
for XPO1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for XPO1:
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent
protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is
involved in the control of several cellular processes by controlling the localization of cyclin B,
MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq]
UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear
export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively
to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP).
Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to
nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the
complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause
release of the cargo from the export receptor. The directionality of nuclear export is thought to
be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to
late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and
influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus.
Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in
HTLV-1 Rex multimerizationGene Wiki entry for XPO1 |
Genomic Location
for XPO1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the XPO1 gene 
Entrez Gene cytogenetic band: 2p16 Ensembl cytogenetic band: 2p15 HGNC cytogenetic band: 2p15XPO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M061616:
(about GC identifiers)
Start:
|
61,558,488 bp from pter |
End:
|
61,618,922 bp from pter |
Size:
|
60,435 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins
for XPO1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980 (See
protein sequence)Recommended Name: Exportin-1 Size: 1071 amino acids; 123386 Da
Subunit: Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped
RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN
and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export
complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1.
Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214 and RANBP3. Also found in complex with several
viral proteins involved in RNAs' nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts
presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1
Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus
and the cytoplasm
Miscellaneous: Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor
PDB structure from  and Proteopedia  :1W9C (3D)
3GB8 (3D)
Secondary accessions: A6NL14 A8K1K5 Q63HP8 Q68CP3 Q99433Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003391.1
ENSEMBL proteins: ENSP00000195419 ENSP00000385559 ENSP00000385257 ENSP00000384863 ENSP00000385942 ENSP00000384826
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for XPO1:
Assays for XPO1: | Protein
Domains/
Families
for XPO1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O14980
ProtoNet protein and cluster: O14980 2 Blocks protein families: IPB001494 Importin-beta IPB013598 Exportin 1-like
UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980Similarity: Belongs to the exportin familySimilarity: Contains 10 HEAT repeatsSimilarity: Contains 1 importin N-terminal domain | Gene Function
for XPO1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003400
 Applied Biosystems Silencer® siRNAs for XPO1
 Sigma-Aldrich siRNA for XPO1
Sigma-Aldrich shRNA for XPO1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_003400
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003400
untagged cDNA clones in CMV expression vector (see all 2): AK094339
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_003400
UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear
export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively
to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP).
Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to
nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the
complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause
release of the cargo from the export receptor. The directionality of nuclear export is thought to
be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to
late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and
influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus.
Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in
HTLV-1 Rex multimerizationGenatlas biochemistry entry for XPO1:exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed
in nuclear pore complex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent
nuclear export of proteins,maybe involved in the leukemogenic effect of DEK-CAN and SET-CAN fusion
chimeric proteins (forming a complex with EIF5A)3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for XPO1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Sigma-Aldrich "Your Favorite Gene" Pathways for XPO1 (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for XPO1
5/10 Interacting proteins for XPO1 (O149801, 2) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000059 | protein import into nucleus, docking |
IEA | -- | | GO:0006611 | protein export from nucleus |
IEA | -- | | GO:0006886 | intracellular protein transport |
IEA | -- | | GO:0009615 | response to virus |
IEA | -- | | GO:0042176 | regulation of protein catabolic process |
IEA | -- |
About this table
|
Drugs & Compounds
for XPO1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for XPO1 |
 Browse Tocris compounds for XPO1
7  Novoseek chemical compound relationships for XPO1 gene
About this table
|
Transcripts
for XPO1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003400
Sigma-Aldrich siRNA for XPO1
Sigma-Aldrich shRNA for XPO1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_003400 REFSEQ mRNAs for XPO1 gene: NM_003400.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003400
OriGene GFP tagged cDNA clone in CMV expression vector: NM_003400
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003400
untagged cDNA clones in CMV expression vector (see all 2): AK094339
Additional cDNA sequence: AK094339.1 AK098297.1 AK124769.1 AK289920.1 AK299039.1 AK312426.1 AK316481.1 AL833550.1 BC032847.2 BX647758.1 CR609163.1 CR749840.1 D89729.1 Y08614.2 24/33 DOTS entries (see all 33
): DT.451914 DT.101970151 DT.65286138 DT.100805049 DT.304652 DT.100029629 DT.70103690 DT.121012048 DT.121011983 DT.100670922 DT.100701374 DT.100844887 DT.418354 DT.91687310 DT.121012023 DT.121012055 DT.86851469 DT.91673128 DT.91713166 DT.92473443 DT.95277044 DT.92040061 DT.97791962 DT.100670913 24/534 AceView cDNA sequences (see all 534
):AI537682 BG697239 BM987308 BQ718761 CA413956 BU186967 CD171887 BM803982 CA430937 AA341872 BX506298 Y08614 BU685025 BE220576 BM787885 BM829878 AI003860 AU130770 BM456804 CA395472 BM713052 BM549274 AI805402 AI754678
 highest scoring ESTs for XPO1:Y08614 AA282076 AI660118 AI761130 AI865913 AL710174 AL710185 AL710257 AL833550 BC032847 Unigene Cluster for XPO1: Exportin 1 (CRM1 homolog, yeast) Hs.370770 [show with all ESTs]Unigene Representative Sequence: AL833550
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for XPO1 (see all 11
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for XPO1
6 Ensembl transcripts including schematic representations: ENST00000195419
ENST00000406957
ENST00000403576
ENST00000401558
ENST00000404992
ENST00000405115
|
Expression
for XPO1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| XPO1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for XPO1
1 / 2 / 3 3 probe-sets matching XPO1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGCATATCAT
SOURCE GeneReport for Unigene cluster: Hs.370770
Expression variation in blood from EXPOLDB for XPO1 UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas,
spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Not expressed in the kidney |
Orthologs
for XPO1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XPO1 gene from 5/24 species (see all 24
)
About this table Species with no ortholog for XPO1
ENSEMBL Gene Tree for XPO1 | Paralogs
for XPO1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for XPO1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for XPO1 (up to first 250kb)
|
Disorders & Mutations
for XPO1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602559
9 Novoseek disease relationships for XPO1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia t-cell |
56.98 |
16 |
9658105 (2), 9765402 (2), 14612415 (2), 16504563 (2) (see all 7) |
| immunodeficiency |
45.42 |
4 |
9765402 (2), 10875611 (1), 10400785 (1) |
| familial adenomatous polyposis |
21.06 |
5 |
18262809 (2), 16378739 (1), 16314428 (1) |
| myeloid leukemia |
14.52 |
1 |
9702053 (1) |
| shock |
0.00 |
2 |
11565755 (1) |
| cancer |
0.00 |
13 |
19117056 (3), 18306389 (1) |
| influenza |
0.00 |
1 |
11118210 (1) |
| tumors |
0.00 |
6 |
18306389 (4), 19082467 (1) |
| hepatitis b |
0.00 |
2 |
12861014 (1), 10875611 (1) |
About this table
|
Medical News
for XPO1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for XPO1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/225 PubMed articles for XPO1 gene (see all 225
):- Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PubMed id 9368044)1, 2, 3, 4 Kudo N....Horinouchi S. (1997)
- Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PubMed id 12724356)1, 3, 4 Thomas F. and Kutay U. (2003)
- RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. (PubMed id 11571268)1, 3, 4 Englmeier L....Kutay U. (2001)
- CRM1 is an export receptor for leucine-rich nuclear export signals. (PubMed id 9323133)1, 3, 4 Fornerod M.... Mattaj I.W. (1997)
- A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PubMed id 14612415)1, 3, 4 Hakata Y.... Shida H. (2003)
- Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. (PubMed id 15632073)1, 3, 4 Daelemans D.... Pavlakis G.N. (2005)
- Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. (PubMed id 11932251)1, 3, 4 Nemergut M.E.... Macara I.G. (2002)
- Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway. (PubMed id 11119609)1, 3, 4 Elton D.... Digard P. (2001)
- CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PubMed id 10209022)1, 3, 4 Paraskeva E.... Goerlich D. (1999)
- The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. (PubMed id 9837918)1, 3, 4 Askjaer P.... Kjems J. (1998)
|
Search for XPO1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing XPO1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing XPO1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XPO1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for XPO1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for XPO1:
 | |
 | | | | |
 |
 |  |  | |
|  | Recombinant Proteins
(CRM1) | | | Antibodies (CRM1) |
| | | | Search Tocris compounds for XPO1 |
|
 |
 | | |
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|
V3 here soon-try beta now
