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XPO1 Gene

protein-coding   GIFtS: 66
GCID: GC02M061704

Exportin 1

(Previous names: exportin 1 (CRM1, yeast, homolog), exportin 1 (CRM1 homolog,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exportin 11 2     CRM1, Yeast, Homolog2
CRM12 3 5     emb2
Exportin 1 (CRM1 Homolog, Yeast)1 2     exp12
Chromosome Region Maintenance 1 Protein Homolog2 3     exportin-12
Chromosome Region Maintenance 1 Homolog (Yeast)1     Exportin-1 (Required For Chromosome Region Maintenance)2
Exportin 1 (CRM1, Yeast, Homolog)1     Exp13
Chromosome Region Maintenance 1 Homolog2     

External Ids:    HGNC: 128251   Entrez Gene: 75142   Ensembl: ENSG000000828987   OMIM: 6025595   UniProtKB: O149803   

Export aliases for XPO1 gene to outside databases

Previous GC identifers: GC02M061833 GC02M061662 GC02M061679 GC02M061616 GC02M061445


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XPO1 Gene:
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport.
Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several
cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also
regulates NFAT and AP-1. (provided by RefSeq, Jul 2008)

GeneCards Summary for XPO1 Gene:
XPO1 (exportin 1) is a protein-coding gene. GO annotations related to this gene include RNA binding and protein domain specific binding.

UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980
Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal
(NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target
protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore
complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the
cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1,
respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is
thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3
snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their
unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of
HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization

Gene Wiki entry for XPO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the XPO1 gene promoter:
         GATA-3   Sp1   Pax-2   Pax-2a   XBP-1   CUTL1   PPAR-gamma1   Pax-2b   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPO1 promoter sequence
   Search Chromatin IP Primers for XPO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XPO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p15

XPO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPO1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M061704:  view genomic region     (about GC identifiers)

Start:
61,704,984 bp from pter      End:
61,765,761 bp from pter
Size:
60,778 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980 (See protein sequence)
Recommended Name: Exportin-1  
Size: 1071 amino acids; 123386 Da
Subunit: Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By
similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a
trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in
a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214,
RANBP3 and TERT. Also found in complex with several viral proteins involved in RNAs' nuclear export like HIV-1
Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1.
Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at
'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus.
Interacts with ATF2
Miscellaneous: Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor
5 PDB 3D structures from and Proteopedia for XPO1:
1W9C (3D)        2L1L (3D)        3GB8 (3D)        4BSM (3D)        4BSN (3D)    
Secondary accessions: A6NL14 A8K1K5 D6W5E2 Q63HP8 Q68CP3 Q99433

Explore the universe of human proteins at neXtProt for XPO1: NX_O14980

Explore proteomics data for XPO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys54, Lys144, Lys415, Lys446, Lys455, Lys479, Lys686, Lys693
  • Modification sites at PhosphoSitePlus

  • See XPO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003391.1  
    ENSEMBL proteins: 
     ENSP00000384863   ENSP00000407170   ENSP00000385942   ENSP00000385559   ENSP00000388927  
     ENSP00000413853   ENSP00000406428   ENSP00000393484   ENSP00000408190   ENSP00000394951  
     ENSP00000406819   ENSP00000390843  
    Reactome Protein details: O14980

    XPO1 Human Recombinant Protein Products:

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    Novus Biologicals XPO1 Protein
    Novus Biologicals XPO1 Lysate
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XPO1

     
    Search eBioscience for Proteins for XPO1 

     
    antibodies-online proteins for XPO1 (2 products) 

     
    antibodies-online peptides for XPO1

    XPO1 Antibody Products:

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    antibodies-online antibodies for XPO1 (46 products) 

    XPO1 Assay Products:

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    Cloud-Clone Corp. ELISAs for XPO1
    Cloud-Clone Corp. CLIAs for XPO1
    Search eBioscience for ELISAs for XPO1 
    antibodies-online kits for XPO1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    XPO: Exportins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-beta_N
     IPR014877 CRM1_C_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O14980

    ProtoNet protein and cluster: O14980

    2 Blocks protein domains:
    IPB001494 Importin-beta
    IPB013598 Exportin 1-like


    UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980
    Similarity: Belongs to the exportin family
    Similarity: Contains 10 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    Find genes that share domains with XPO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPO1_HUMAN, O14980
    Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal
    (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target
    protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore
    complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the
    cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1,
    respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is
    thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the
    cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3
    snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their
    unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of
    HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization

         Genatlas biochemistry entry for XPO1:
    exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed in nuclear
    pore complex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent nuclear export of
    proteins,maybe involved in the leukemogenic effect of DEK-CAN and SET-CAN fusion chimeric proteins (forming a
    complex with EIF5A)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005215transporter activity TAS--
    GO:0005488binding ----
    GO:0005515protein binding IPI11545741
    GO:0008536Ran GTPase binding IEA--
         
    Find genes that share ontologies with XPO1           About GenesLikeMe


    Phenotypes:
         10 GenomeRNAi human phenotypes for XPO1:
     Decreased cell number, increas  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased viability of wild-ty  Increased cell death in HCT116  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for XPO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target XPO1:
    hsa-mir-30a-5p (MIRT028476), hsa-mir-23b-3p (MIRT046310), hsa-mir-125a-5p (MIRT045717), hsa-mir-1236-3p (MIRT036257), hsa-mir-192-5p (MIRT026224), hsa-mir-16-5p (MIRT031490), hsa-mir-155-5p (MIRT020549), hsa-mir-193b-3p (MIRT016294), hsa-mir-92a-3p (MIRT049604), hsa-mir-17-3p (MIRT050787)

    Block miRNA regulation of human, mouse, rat XPO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate XPO1 (see all 60):
    hsa-miR-219-1-3p hsa-miR-26a-2* hsa-miR-562 hsa-miR-300 hsa-miR-513a-5p hsa-miR-30d hsa-miR-371-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidXPO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat XPO1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: XPO1 (NM_003400)
    Sino Biological Human cDNA Clone for XPO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO1
    Addgene plasmids for XPO1 

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XPO1_HUMAN, O14980: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in
    the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA17363900
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS9368044
    GO:0005642annulate lamellae IDA12210765
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with XPO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XPO1 About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.91
    NEP/NS2 Interacts with the Cellular Export Machinery0.91
    Interactions of Rev with host cellular proteins0.91
    Export of Viral Ribonucleoproteins from Nucleus0.88
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with XPO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for XPO1
        SMAD Signaling Network
    Ran Pathway
    NFAT in Immune Response

    2 GeneGo (Thomson Reuters) Pathways for XPO1
        Cell cycle ESR1 regulation of G1/S transition
    Immune response MIF-JAB1 signaling

    Selected BioSystems Pathways for XPO1 (see all 9)
        TGF-beta Receptor Signaling Pathway
    Signaling events mediated by HDAC Class I
    Role of Calcineurin-dependent NFAT signaling in lymphocytes
    Sumoylation by RanBP2 regulates transcriptional repression
    Canonical NF-kappaB pathway


    Selected Reactome Pathways for XPO1 (see all 9)
        deactivation of the beta-catenin transactivating complex
    Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    NEP/NS2 Interacts with the Cellular Export Machinery
    HuR stabilizes mRNA


    5 Kegg Pathways  (Kegg details for XPO1):
        Ribosome biogenesis in eukaryotes
    RNA transport
    Influenza A
    HTLV-I infection
    Epstein-Barr virus infection

        Pathway & Disease-focused RT2 Profiler PCR Array including XPO1: 
              HIV Host Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for XPO1

    Selected Interacting proteins for XPO1 (O149801, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 217)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BIRC5O153921, 2, 3EBI-355867,EBI-518823 MINT-4055407 MINT-4509587 I2D: score=3 
    PKIAP619251, 2, 3EBI-355867,EBI-2682139 MINT-7950829 MINT-7950372 I2D: score=1 
    DDX3XO005712, 3MINT-7234858 I2D: score=3 
    HSP90AB1P082382, 3MINT-72646 I2D: score=3 
    PHBP352321, 3EBI-355867,EBI-354213 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000278mitotic cell cycle TAS--
    GO:0006611protein export from nucleus IEA--
    GO:0006886intracellular protein transport ----
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    Find genes that share ontologies with XPO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for XPO1
      Browse compounds at ApexBio 

    Browse Tocris compounds for XPO1

    1 HMDB Compound for XPO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for XPO1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 96.9 81 9683540 (9), 12519765 (2), 11704659 (2), 10639332 (2) (see all 46)
    leptomycin 91.3 2 9323133 (1), 11733048 (1)
    tetramethylammonium hydroxide 50.8 5 12724356 (4), 17347149 (1)
    gtp 43.4 5 10330396 (1), 9765402 (1), 14688242 (1), 19339972 (1) (see all 5)
    threonine 24.9 1 11162834 (1)
    serine 23.3 2 11162834 (1), 11060306 (1)
    leucine 21.2 8 10339570 (2), 11704659 (2), 18316374 (1), 9837918 (1)
    alanine 17.9 4 11704659 (1), 16513647 (1), 15128734 (1)
    calcitriol 14.9 3 16707848 (2), 16847355 (1)
    glucose 0 3 15128734 (2)



    Find genes that share compounds with XPO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XPO1 gene: 
    NM_003400.3  

    Unigene Cluster for XPO1:

    Exportin 1 (CRM1 homolog, yeast)
    Hs.370770  [show with all ESTs]
    Unigene Representative Sequence: AL833550
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000401558(uc010fcl.3 uc010ypn.2 uc002sbj.3) ENST00000428210(uc002sbk.3)
    ENST00000481073(uc002sbh.3) ENST00000404992 ENST00000406957 ENST00000492182
    ENST00000461407 ENST00000494468 ENST00000469337 ENST00000460037 ENST00000475744
    ENST00000437159 ENST00000489954 ENST00000451765 ENST00000443240 ENST00000476585
    ENST00000468259 ENST00000420673
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate XPO1 (see all 60):
    hsa-miR-219-1-3p hsa-miR-26a-2* hsa-miR-562 hsa-miR-300 hsa-miR-513a-5p hsa-miR-30d hsa-miR-371-5p hsa-miR-570
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    GenScript: all cDNA clones in your preferred vector: XPO1 (NM_003400)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XPO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPO1
    Addgene plasmids for XPO1 
    Primer
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    OriGene qPCR primer pairs and template standards for XPO1
    OriGene qSTAR qPCR primer pairs in human, mouse for XPO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XPO1
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    eBioscience FlowRNA Probe Sets ( VA1-12200) for XPO1 

    Additional mRNA sequence: 

    AK094339.1 AK098297.1 AK124769.1 AK289920.1 AK299039.1 AK312426.1 AK316481.1 AL833550.1 
    BC032847.2 BX647758.1 CR749840.1 D89729.1 Y08614.2 

    Selected DOTS entries (see all 35):

    DT.451914  DT.101970151  DT.65286138  DT.100805049  DT.100029629  DT.304652  DT.70103690  DT.121012048 
    DT.121011983  DT.100670922  DT.100701374  DT.100844887  DT.418354  DT.91687310  DT.91886607  DT.121012023 
    DT.121012055  DT.91713166  DT.92473443  DT.95277044  DT.91673128  DT.92040061  DT.97791962  DT.100670913 

    Selected AceView cDNA sequences (see all 534):

    BM453783 AK124769 AA665649 AI393504 CK823937 BU154406 AU118302 CA413956 
    BM786663 BU682921 AL601540 BX506298 BQ018529 AI795929 BM903778 AU143284 
    AW189769 BQ019649 AI754678 BG679798 BI257819 CF142566 BU685025 BU431738 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for XPO1 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
    SP1:              -     -                       -     -                                                                       -           -                     
    SP2:                                                                                                                                      -                     
    SP3:                                                                    -                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
    SP1:                                            -     -                                 
    SP2:                                            -     -                                 
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for XPO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    XPO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATATCAT
    XPO1 Expression
    About this image


    XPO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    XPO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XPO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370770

    UniProtKB/Swiss-Prot: XPO1_HUMAN, O14980
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus,
    prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including XPO1: 
              HIV Host Response in human mouse rat

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    OriGene qPCR primer pairs and template standards for XPO1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPO1 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpo11 , 5 exportin 1, CRM1 homolog (yeast)1, 5 91.53(n)1
    98.04(a)1
      11 (14.28 cM)5
    1035731  NM_001035226.11  NP_001030303.11 
     232560555 
    chicken
    (Gallus gallus)
    Aves XPO11 exportin 1 (CRM1 homolog, yeast) 86.9(n)
    98.6(a)
      421192  NM_001012869.2  NP_001012887.2 
    lizard
    (Anolis carolinensis)
    Reptilia XPO16
    exportin 1 (CRM1 homolog, yeast)
    98(a)
    1 ↔ 1
    GL343523.1(123783-158075)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xpo12 CRM1/XPO1 protein 81.34(n)    AF158021.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF996432.12   -- 75.61(n)    CF996432.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta emb1 , 3 protein-nucleus export nuclear export
    signal receptor3
    embargoed1
    70(a)3
    63.02(n)1
    71.39(a)1
      341671  NM_164818.11  NP_723391.21 
    worm
    (Caenorhabditis elegans)
    Secernentea xpo-11 xpo-1 55.82(n)
    52.55(a)
      179160  NM_171484.5  NP_741567.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CRM11 CRM1 55.07(n)
    48.29(a)
      853133   NP_011734.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XPO1A1 XPO1A 56.44(n)
    50.33(a)
      831565  NM_121708.2  NP_197204.1 
    rice
    (Oryza sativa)
    Liliopsida Os.92582 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.93(n)    AK100745.1 


    ENSEMBL Gene Tree for XPO1 (if available)
    TreeFam Gene Tree for XPO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for XPO1 (see all 1322)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814201091,2
    Cuntested161757808(+) ACAGAC/G/TTAAAA 1 -- int10--------
    rs1149587211,2
    F--61704607(+) AGTGAT/ACCGCC 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1402790011,2
    C--61704645(+) TACAGA/GTGTGA 1 -- ds50010--------
    rs1443339271,2
    --61704649(+) GGTGTC/GAGCTA 1 -- ds50010--------
    rs1504754671,2
    C--61704700(+) TACTT-/AAGTTT 1 -- ds50010--------
    rs1863947621,2
    --61704728(+) ATACAA/GTTAGT 1 -- ds50010--------
    rs1154221441,2
    F--61704734(+) TTAGTA/GTTTGT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1455256041,2
    C--61704958(+) TTAGAA/CATCTT 1 -- ds50010--------
    rs1904552761,2
    --61705040(+) TAATAC/TAGGAA 1 -- ds50010--------
    rs1816890351,2
    --61705115(+) TTAAAA/GCACTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for XPO1 (61704984 - 61765761 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for XPO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2463303CNV Deletion19546169
    nsv874228CNV Loss21882294
    dgv4158n71CNV Loss21882294
    nsv9935CNV Loss18304495
    nsv483028CNV Loss15286789
    nsv874226CNV Loss21882294
    nsv874227CNV Gain21882294
    nsv9946CNV Gain+Loss18304495
    nsv7313OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): XPO1
    2 Site Specific Mutation Identification with PCR Assays for XPO1:
    Cosmic IdAA Change
    99000073p.E571G
    99000072p.E571K
    SeqTarget long-range PCR primers for resequencing XPO1
    DNA2.0 Custom Variant and Variant Library Synthesis for XPO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602559    OMIM disorders: --


    Find genes that share disorders with XPO1           About GenesLikeMe

    9 Novoseek inferred disease relationships for XPO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 55.1 16 9658105 (2), 9765402 (2), 14612415 (2), 16504563 (2) (see all 7)
    immunodeficiency 46.2 5 9765402 (2), 19776134 (1), 10875611 (1), 10400785 (1)
    familial adenomatous polyposis 18.5 5 18262809 (2), 16378739 (1), 16314428 (1)
    myeloid leukemia 11.9 1 9702053 (1)
    shock 0 2 11565755 (1)
    tumors 0 7 18306389 (4), 19082467 (1), 19574837 (1)
    influenza 0 1 11118210 (1)
    hepatitis b 0 2 12861014 (1), 10875611 (1)
    cancer 0 14 19117056 (3), 20003838 (1), 18306389 (1)

    Genetic Association Database (GAD): XPO1

    Export disorders for XPO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XPO1 gene, integrated from 10 sources (see all 394):
    (articles sorted by number of sources associating them with XPO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PubMed id 9368044)1, 2, 3, 9 Kudo N....Horinouchi S. (J. Biol. Chem. 1997)
    2. Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PubMed id 12724356)1, 2, 9 Thomas F. and Kutay U. (J. Cell Sci. 2003)
    3. RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. (PubMed id 11571268)1, 2, 9 Englmeier L....Kutay U. (EMBO Rep. 2001)
    4. CRM1 is an export receptor for leucine-rich nuclear export signals. (PubMed id 9323133)1, 2, 9 Fornerod M.... Mattaj I.W. (Cell 1997)
    5. A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PubMed id 14612415)1, 2, 9 Hakata Y.... Shida H. (Mol. Cell. Biol. 2003)
    6. Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. (PubMed id 15632073)1, 2, 9 Daelemans D.... Pavlakis G.N. (Mol. Cell. Biol. 2005)
    7. Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. (PubMed id 11932251)1, 2, 9 Nemergut M.E.... Macara I.G. (J. Biol. Chem. 2002)
    8. Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway. (PubMed id 11119609)1, 2, 9 Elton D.... Digard P. (J. Virol. 2001)
    9. CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PubMed id 10209022)1, 2, 9 Paraskeva E.... Goerlich D. (J. Cell Biol. 1999)
    10. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. (PubMed id 9837918)1, 2, 9 Askjaer P.... Kjems J. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7514 HGNC: 12825 AceView: XPO1 Ensembl:ENSG00000082898 euGenes: HUgn7514
    ECgene: XPO1 Kegg: 7514 H-InvDB: XPO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for XPO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for XPO1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for XPO1 gene:
    Search GeneIP for patents involving XPO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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