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Aliases for XPO1 Gene

Aliases for XPO1 Gene

  • Exportin 1 2 3 5
  • Chromosome Region Maintenance 1 Protein Homolog 3 4
  • Exportin 1 (CRM1 Homolog, Yeast) 2 3
  • Exp1 3 4
  • CRM1 3 4
  • Exportin-1 (Required For Chromosome Region Maintenance) 3
  • Chromosome Region Maintenance 1 Homolog (Yeast) 2
  • Chromosome Region Maintenance 1 Homolog 3
  • Exportin 1 (CRM1, Yeast, Homolog) 2
  • Emb 3

External Ids for XPO1 Gene

Previous GeneCards Identifiers for XPO1 Gene

  • GC02M061833
  • GC02M061662
  • GC02M061679
  • GC02M061616
  • GC02M061704

Summaries for XPO1 Gene

Entrez Gene Summary for XPO1 Gene

  • This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

GeneCards Summary for XPO1 Gene

XPO1 (Exportin 1) is a Protein Coding gene. Diseases associated with XPO1 include influenza and mixed malaria. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include RNA binding and transporter activity.

UniProtKB/Swiss-Prot for XPO1 Gene

  • Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Gene Wiki entry for XPO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO1 Gene

Genomics for XPO1 Gene

Regulatory Elements for XPO1 Gene

Promoters for XPO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around XPO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for XPO1 Gene

Chromosome:
2
Start:
61,477,849 bp from pter
End:
61,538,626 bp from pter
Size:
60,778 bases
Orientation:
Minus strand

Genomic View for XPO1 Gene

Genes around XPO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO1 Gene

Proteins for XPO1 Gene

  • Protein details for XPO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14980-XPO1_HUMAN
    Recommended name:
    Exportin-1
    Protein Accession:
    O14980
    Secondary Accessions:
    • A6NL14
    • A8K1K5
    • D6W5E2
    • Q63HP8
    • Q68CP3
    • Q99433

    Protein attributes for XPO1 Gene

    Size:
    1071 amino acids
    Molecular mass:
    123386 Da
    Quaternary structure:
    • Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Also found in complex with several viral proteins involved in RNAs nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at Lys-129. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8.
    Miscellaneous:
    • Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.

    Three dimensional structures from OCA and Proteopedia for XPO1 Gene

neXtProt entry for XPO1 Gene

Proteomics data for XPO1 Gene at MOPED

Post-translational modifications for XPO1 Gene

  • Ubiquitination at Lys 54, Lys 144, Lys 415, Lys 455, Lys 479, Lys 686, and Lys 693
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for XPO1 Gene

Domains & Families for XPO1 Gene

Gene Families for XPO1 Gene

Suggested Antigen Peptide Sequences for XPO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14980

UniProtKB/Swiss-Prot:

XPO1_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the exportin family.
  • Contains 10 HEAT repeats.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the exportin family.
Similarity:
  • Contains 10 HEAT repeats.
genes like me logo Genes that share domains with XPO1: view

Function for XPO1 Gene

Molecular function for XPO1 Gene

GENATLAS Biochemistry:
exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed in nuclear pore complex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent nuclear export of proteins,maybe involved in the leukemogenic effect of DEK-CAN and SET-CAN fusion chimeric proteins (forming a complex with EIF5A)
UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Gene Ontology (GO) - Molecular Function for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS --
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with XPO1: view
genes like me logo Genes that share phenotypes with XPO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for XPO1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO1 Gene

Localization for XPO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO1 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPO1 Gene COMPARTMENTS Subcellular localization image for XPO1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with XPO1: view

Pathways & Interactions for XPO1 Gene

genes like me logo Genes that share pathways with XPO1: view

SIGNOR curated interactions for XPO1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000056 ribosomal small subunit export from nucleus IMP 12773398
GO:0006611 protein export from nucleus IMP 12773398
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with XPO1: view

Drugs & Compounds for XPO1 Gene

(8) Drugs for XPO1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(5) Additional Compounds for XPO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XPO1: view

Transcripts for XPO1 Gene

Unigene Clusters for XPO1 Gene

Exportin 1 (CRM1 homolog, yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: - -
SP8: -
SP9:
SP10: - -
SP11: -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for XPO1 Gene

GeneLoc Exon Structure for
XPO1
ECgene alternative splicing isoforms for
XPO1

Expression for XPO1 Gene

mRNA expression in normal human tissues for XPO1 Gene

Protein differential expression in normal tissues from HIPED for XPO1 Gene

This gene is overexpressed in Bone (48.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPO1 Gene



SOURCE GeneReport for Unigene cluster for XPO1 Gene Hs.370770

mRNA Expression by UniProt/SwissProt for XPO1 Gene

O14980-XPO1_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.
genes like me logo Genes that share expression patterns with XPO1: view

Protein tissue co-expression partners for XPO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for XPO1 Gene

Orthologs for XPO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO1 36
  • 100 (a)
OneToOne
XPO1 35
  • 99.75 (n)
  • 99.91 (a)
cow
(Bos Taurus)
Mammalia XPO1 35
  • 93.65 (n)
  • 98.88 (a)
XPO1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO1 36
  • 99 (a)
OneToOne
XPO1 35
  • 94.37 (n)
  • 98.88 (a)
mouse
(Mus musculus)
Mammalia Xpo1 16
Xpo1 36
  • 98 (a)
OneToOne
Xpo1 35
  • 91.53 (n)
  • 98.04 (a)
oppossum
(Monodelphis domestica)
Mammalia XPO1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XPO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xpo1 35
  • 89.57 (n)
  • 97.85 (a)
chicken
(Gallus gallus)
Aves XPO1 35
  • 86.9 (n)
  • 98.6 (a)
-- 36
  • 91 (a)
OneToMany
XPO1 36
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia XPO1 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xpo1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2050 35
xpo1 35
  • 81.89 (n)
  • 97.76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6091 35
zebrafish
(Danio rerio)
Actinopterygii xpo1a 36
  • 88 (a)
OneToMany
xpo1b 36
  • 96 (a)
OneToMany
xpo1b 35
  • 77.68 (n)
  • 96.27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009929 35
  • 63.69 (n)
  • 72.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta emb 35
  • 63.02 (n)
  • 71.39 (a)
emb 37
  • 70 (a)
emb 36
  • 71 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea xpo-1 35
  • 55.82 (n)
  • 52.55 (a)
xpo-1 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL128C 35
  • 53.54 (n)
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRM1 35
  • 55.07 (n)
  • 48.29 (a)
CRM1 36
  • 46 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16061g 35
  • 54.42 (n)
  • 47.67 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons XPO1A 35
  • 56.44 (n)
  • 50.33 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1208 35
rice
(Oryza sativa)
Liliopsida Os.9258 35
Os03g0858100 35
  • 56.65 (n)
  • 50.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01820 35
  • 53.82 (n)
  • 53.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes crm1 35
  • 59.23 (n)
  • 55.48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5454 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2375 36
  • 73 (a)
OneToOne
Species with no ortholog for XPO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO1 Gene

ENSEMBL:
Gene Tree for XPO1 (if available)
TreeFam:
Gene Tree for XPO1 (if available)

Paralogs for XPO1 Gene

No data available for Paralogs for XPO1 Gene

Variants for XPO1 Gene

Sequence variations from dbSNP and Humsavar for XPO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs995710 -- 61,537,511(+) gcccg(C/G)cccgc intron-variant
rs1802545 -- 61,485,899(-) ATGTC(C/T)CAGCT reference, missense
rs1965841 -- 61,540,272(+) ctact(A/G)aagat upstream-variant-2KB
rs2084195 -- 61,529,400(-) GATTA(A/C)AGGCG intron-variant
rs2305154 -- 61,502,095(+) GAATA(C/T)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XPO1 Gene

Variant ID Type Subtype PubMed ID
dgv4158n71 CNV Loss 21882294
nsv7313 OTHER Inversion 18451855
nsv874226 CNV Loss 21882294
nsv874227 CNV Gain 21882294
nsv483028 CNV Loss 15286789
nsv874228 CNV Loss 21882294
nsv9935 CNV Loss 18304495
esv2463303 CNV Deletion 19546169
nsv9946 CNV Gain+Loss 18304495

Variation tolerance for XPO1 Gene

Residual Variation Intolerance Score: 3.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XPO1 Gene

HapMap Linkage Disequilibrium report
XPO1
Human Gene Mutation Database (HGMD)
XPO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO1 Gene

Disorders for XPO1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for XPO1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
mixed malaria
  • malaria by more than one parasite
tooth ankylosis
  • ankylosis of teeth
chromosome 2p16.1-p15 deletion syndrome
  • 2p15-p16.1 microdeletion syndrome
peritoneal mesothelioma
  • advanced malignant mesothelioma of peritoneum
- elite association - COSMIC cancer census association via MalaCards
Search XPO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for XPO1

Genetic Association Database (GAD)
XPO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XPO1
genes like me logo Genes that share disorders with XPO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPO1 Gene

Publications for XPO1 Gene

  1. Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PMID: 9368044) Kudo N. … Horinouchi S. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. (PMID: 20026644) von Knethen A. … BrA1ne B. (J. Cell. Sci. 2010) 3 23
  3. Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins. (PMID: 20233715) Takeda A. … Yaseen N.R. (J. Biol. Chem. 2010) 3 23
  4. The expression of CRM1 is associated with prognosis in human osteosarcoma. (PMID: 19082467) Yao Y. … Zheng S.E. (Oncol. Rep. 2009) 3 23
  5. The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. (PMID: 19117056) van der Watt P.J. … Leaner V.D. (Int. J. Cancer 2009) 3 23

Products for XPO1 Gene

Sources for XPO1 Gene

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