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Aliases for XPO1 Gene

Aliases for XPO1 Gene

  • Exportin 1 2 3
  • CRM1 3 4 6
  • Chromosome Region Maintenance 1 Protein Homolog 3 4
  • Exportin 1 (CRM1 Homolog, Yeast) 2 3
  • Exp1 3 4
  • Exportin-1 (Required For Chromosome Region Maintenance) 3
  • Chromosome Region Maintenance 1 Homolog (Yeast) 2
  • Chromosome Region Maintenance 1 Homolog 3
  • Exportin 1 (CRM1, Yeast, Homolog) 2
  • Exportin-1 3
  • Emb 3

External Ids for XPO1 Gene

Previous GeneCards Identifiers for XPO1 Gene

  • GC02M061833
  • GC02M061662
  • GC02M061679
  • GC02M061616
  • GC02M061704

Summaries for XPO1 Gene

Entrez Gene Summary for XPO1 Gene

  • This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

GeneCards Summary for XPO1 Gene

XPO1 (Exportin 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include RNA binding and protein domain specific binding.

UniProtKB/Swiss-Prot for XPO1 Gene

  • Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Gene Wiki entry for XPO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO1 Gene

Genomics for XPO1 Gene

Regulatory Elements for XPO1 Gene

Genomic Location for XPO1 Gene

Start:
61,477,849 bp from pter
End:
61,538,626 bp from pter
Size:
60,778 bases
Orientation:
Minus strand

Genomic View for XPO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XPO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO1 Gene

Proteins for XPO1 Gene

  • Protein details for XPO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14980-XPO1_HUMAN
    Recommended name:
    Exportin-1
    Protein Accession:
    O14980
    Secondary Accessions:
    • A6NL14
    • A8K1K5
    • D6W5E2
    • Q63HP8
    • Q68CP3
    • Q99433

    Protein attributes for XPO1 Gene

    Size:
    1071 amino acids
    Molecular mass:
    123386 Da
    Quaternary structure:
    • Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Also found in complex with several viral proteins involved in RNAs nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at Lys-129. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8.
    Miscellaneous:
    • Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor

    Three dimensional structures from OCA and Proteopedia for XPO1 Gene

neXtProt entry for XPO1 Gene

Proteomics data for XPO1 Gene at MOPED

Post-translational modifications for XPO1 Gene

  • Ubiquitination at Lys54, Lys144, Lys415, Lys446, Lys455, Lys479, Lys686, and Lys693
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for XPO1 Gene

Domains for XPO1 Gene

Gene Families for XPO1 Gene

HGNC:
  • XPO :Exportins

Suggested Antigen Peptide Sequences for XPO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14980

UniProtKB/Swiss-Prot:

XPO1_HUMAN :
  • O14980
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the exportin family.
Similarity:
  • Contains 10 HEAT repeats.
genes like me logo Genes that share domains with XPO1: view

Function for XPO1 Gene

Molecular function for XPO1 Gene

GENATLAS Biochemistry: exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed in nuclear pore complex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent nuclear export of proteins,maybe involved in the leukemogenic effect of DEK-CAN and SET-CAN fusion chimeric proteins (forming a complex with EIF5A)
UniProtKB/Swiss-Prot Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Gene Ontology (GO) - Molecular Function for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005215 transporter activity TAS --
GO:0005487 nucleocytoplasmic transporter activity IMP 12773398
GO:0005488 binding --
GO:0005515 protein binding IPI 11545741
genes like me logo Genes that share ontologies with XPO1: view
genes like me logo Genes that share phenotypes with XPO1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for XPO1 Gene

Localization for XPO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO1 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XPO1 Gene COMPARTMENTS Subcellular localization image for XPO1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 17363900
GO:0005634 nucleus IDA --
GO:0005635 nuclear envelope TAS 9368044
GO:0005642 annulate lamellae IDA 12210765
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with XPO1: view

Pathways for XPO1 Gene

genes like me logo Genes that share pathways with XPO1: view

Gene Ontology (GO) - Biological Process for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 ribosomal small subunit export from nucleus IMP 12773398
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000278 mitotic cell cycle TAS --
GO:0006611 protein export from nucleus IMP 12773398
genes like me logo Genes that share ontologies with XPO1: view

Compounds for XPO1 Gene

(1) HMDB Compounds for XPO1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(12) Novoseek inferred chemical compound relationships for XPO1 Gene

Compound -log(P) Hits PubMed IDs
leptomycin b 96.9 57
leptomycin 91.3 2
tetramethylammonium hydroxide 50.8 5
gtp 43.4 5
threonine 24.9 1
genes like me logo Genes that share compounds with XPO1: view

Transcripts for XPO1 Gene

Unigene Clusters for XPO1 Gene

Exportin 1 (CRM1 homolog, yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XPO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: - -
SP8: -
SP9:
SP10: - -
SP11: -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for XPO1 Gene

GeneLoc Exon Structure for
XPO1
ECgene alternative splicing isoforms for
XPO1

Expression for XPO1 Gene

mRNA expression in normal human tissues for XPO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for XPO1 Gene

SOURCE GeneReport for Unigene cluster for XPO1 Gene Hs.370770

mRNA Expression by UniProt/SwissProt for XPO1 Gene

O14980-XPO1_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.
genes like me logo Genes that share expressions with XPO1: view

No data available for mRNA differential expression in normal tissues for XPO1 Gene

Orthologs for XPO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO1 35
  • 99.75 (n)
  • 99.91 (a)
XPO1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XPO1 35
  • 93.65 (n)
  • 98.88 (a)
XPO1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO1 35
  • 94.37 (n)
  • 98.88 (a)
XPO1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo1 35
  • 91.53 (n)
  • 98.04 (a)
Xpo1 16
Xpo1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPO1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XPO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xpo1 35
  • 89.57 (n)
  • 97.85 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 91 (a)
OneToMany
XPO1 35
  • 86.9 (n)
  • 98.6 (a)
XPO1 36
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia XPO1 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xpo1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2050 35
xpo1 35
  • 81.89 (n)
  • 97.76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6091 35
zebrafish
(Danio rerio)
Actinopterygii xpo1a 36
  • 88 (a)
OneToMany
xpo1b 35
  • 77.68 (n)
  • 96.27 (a)
xpo1b 36
  • 96 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009929 35
  • 63.69 (n)
  • 72.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta emb 35
  • 63.02 (n)
  • 71.39 (a)
emb 36
  • 71 (a)
OneToOne
emb 37
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea xpo-1 35
  • 55.82 (n)
  • 52.55 (a)
xpo-1 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL128C 35
  • 53.54 (n)
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRM1 35
  • 55.07 (n)
  • 48.29 (a)
CRM1 36
  • 46 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16061g 35
  • 54.42 (n)
  • 47.67 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons XPO1A 35
  • 56.44 (n)
  • 50.33 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1208 35
rice
(Oryza sativa)
Liliopsida Os.9258 35
Os03g0858100 35
  • 56.65 (n)
  • 50.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01820 35
  • 53.82 (n)
  • 53.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes crm1 35
  • 59.23 (n)
  • 55.48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5454 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2375 36
  • 73 (a)
OneToOne
Species with no ortholog for XPO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO1 Gene

ENSEMBL:
Gene Tree for XPO1 (if available)
TreeFam:
Gene Tree for XPO1 (if available)

Paralogs for XPO1 Gene

No data available for Paralogs for XPO1 Gene

Variants for XPO1 Gene

Sequence variations from dbSNP and Humsavar for XPO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14013 -- 61,478,152(-) TTTCC(C/T)CAATG utr-variant-3-prime
rs766447 -- 61,508,434(-) TGTTA(A/G)ACACA intron-variant
rs766448 -- 61,508,311(-) CTACG(A/G)GTGTG intron-variant
rs995710 -- 61,537,511(+) gcccg(C/G)cccgc intron-variant
rs1050567 -- 61,478,528(-) AATTC(A/G)ATTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for XPO1 Gene

Variant ID Type Subtype PubMed ID
dgv4158n71 CNV Loss 21882294
nsv7313 OTHER Inversion 18451855
nsv874226 CNV Loss 21882294
nsv874227 CNV Gain 21882294
nsv483028 CNV Loss 15286789
nsv874228 CNV Loss 21882294
nsv9935 CNV Loss 18304495
esv2463303 CNV Deletion 19546169
nsv9946 CNV Gain+Loss 18304495

Relevant External Links for XPO1 Gene

HapMap Linkage Disequilibrium report
XPO1
Human Gene Mutation Database (HGMD)
XPO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO1 Gene

Disorders for XPO1 Gene

(9) Novoseek inferred disease relationships for XPO1 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 55.1 11
immunodeficiency 46.2 5
familial adenomatous polyposis 18.5 4
myeloid leukemia 11.9 1
shock 0 1

Relevant External Links for XPO1

Genetic Association Database (GAD)
XPO1
genes like me logo Genes that share disorders with XPO1: view

No data available for UniProtKB/Swiss-Prot for XPO1 Gene

Publications for XPO1 Gene

  1. Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PMID: 9368044) Kudo N. … Horinouchi S. (J. Biol. Chem. 1997) 2 3 4 23
  2. CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PMID: 10209022) Paraskeva E. … Goerlich D. (J. Cell Biol. 1999) 3 4 23
  3. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. (PMID: 9837918) Askjaer P. … Kjems J. (J. Biol. Chem. 1998) 3 4 23
  4. CRM1 is an export receptor for leucine-rich nuclear export signals. (PMID: 9323133) Fornerod M. … Mattaj I.W. (Cell 1997) 3 4 23
  5. RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. (PMID: 11571268) Englmeier L. … Kutay U. (EMBO Rep. 2001) 3 4 23

Products for XPO1 Gene

  • Addgene plasmids for XPO1

Sources for XPO1 Gene

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