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XPNPEP3 Gene

protein-coding   GIFtS: 49

GC22P039583
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
APP3 1, 2, 3
EC 3.4.11.9 3
OTTHUMP00000028904 2
Descriptions
Aminopeptidase P3 3
X-Pro aminopeptidase 3 3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative 2
External Ids
HGNC: 280521
Entrez Gene: 639292
UniProtKB: Q9NQH73
Ensembl: ENSG000001962367
Search outside databases for aliases for XPNPEP3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31-q13.33   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

XPNPEP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039583:     (about GC identifiers)

Start:
39,583,040 bp from pter
End:
39,653,829 bp from pter
Size:
70,790 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XPP3_HUMAN, Q9NQH7 (See protein sequence)
Recommended Name: Probable Xaa-Pro aminopeptidase 3  
Size: 507 amino acids; 57034 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Secondary accessions: Q6I9V9 Q8NDA6 Q9BV27 Q9BVH0
Alternative splicing: 3 isoforms:  Q9NQH7-1   Q9NQH7-2   Q9NQH7-3   

REFSEQ proteins: NP_071381.1  

ENSEMBL proteins: 
ENSP00000349658 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (XPNPEP3)
Human Recombinant Proteins from Abnova (LOC63929)
              OriGene Purified Recombinant Human Protein: XPNPEP3 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IDA18029348
GO:0005737 cytoplasm IDA18029348
GO:0005739 mitochondrion IEA--
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Antibodies for XPNPEP3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for XPNPEP3
Browse R&D Systems for Antibodies
Antibodies from Abcam (XPNPEP3), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (LOC63929)
Novus Biologicals Antibody for XPNPEP3

Assays for XPNPEP3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR007865 Pept_M24B_aminopep_P
 IPR000994 Pept_M24_structural-domain


   GeneDecks  XPNPEP3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9NQH7

ProtoNet protein and cluster: Q9NQH7

1 Blocks protein family: IPB007865 Aminopeptidase P

UniProtKB/Swiss-Prot: XPP3_HUMAN, Q9NQH7
Similarity: Belongs to the peptidase M24B family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (XPNPEP3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC001208

              Applied Biosystems Silencer® siRNAs for XPNPEP3

              Sigma-Aldrich siRNA and siRNA Panels for XPNPEP3  
                     Sigma-Aldrich shRNA for XPNPEP3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for XPNPEP3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022098
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022098
                                 untagged cDNA clones in CMV expression vector (see all 3): BC001208 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_022098

UniProtKB/Swiss-Prot: XPP3_HUMAN, Q9NQH7
Catalytic activity: Release of any N-terminal amino acid, including proline, that is linked to
proline, even from a dipeptide or tripeptide
Enzyme Number (IUBMB): EC 3.4.11.9 

1 MGI phenotypic allele for Xpnpep3 (no phenotypes)


5 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004177 aminopeptidase activity IEA--
GO:0008233 peptidase activity IEA--
GO:0008237 metallopeptidase activity IEA--
GO:0030145 manganese ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0009987 cellular process IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for XPNPEP3
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XPNPEP3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (XPNPEP3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC001208

              Sigma-Aldrich siRNA and siRNA Panels for XPNPEP3  
                     Sigma-Aldrich shRNA for XPNPEP3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_022098  

REFSEQ mRNAs for XPNPEP3 gene: 

NM_022098.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_022098  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022098
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022098
                                 untagged cDNA clones in CMV expression vector (see all 3): BC001208 

Additional cDNA sequence: 

AK057119.1 AK301635.1 AK301758.1 AK310502.1 AK313770.1 AL365514.1 AL834310.1 BC001208.1 
BC001681.2 BC004989.1 BC005331.1 BC011632.2 BC016735.1 BC023654.2 BC032537.1 BC045166.1 
BC053556.1 BC062446.1 BX648018.1 CR456442.1 CR457396.1 

22 DOTS entries:

DT.205707  DT.97763705  DT.107910  DT.85105369  DT.105823  DT.92425919  DT.120649898  DT.121643852 
DT.442197  DT.100017483  DT.100747943  DT.120649998  DT.100017002  DT.121643429  DT.100733032  DT.102829080 
DT.113562  DT.120649917  DT.120649932  DT.95370228  DT.100813100  DT.100813103 

24/235 AceView cDNA sequences (see all 235 ):

AI446638 BX119041 N43765 BU628809 BC053556 AI377541 BM980889 CA941832 
CR456442 AA121920 BC023654 BQ446896 AI244347 BX108020 AL834310 AI373300 
AA700729 BF195962 BU620669 BU584042 BC001681 BC037424 BC011632 AI052824 

highest scoring ESTs for XPNPEP3:

AI479803 AI743845 AA234193 AA234273 AA236366 AA312950 AA382300 AA665693 AA699699 AA743536 

Unigene Cluster for XPNPEP3:

X-prolyl aminopeptidase (aminopeptidase P) 3, putative
Hs.529163  [show with all ESTs]
Unigene Representative Sequence: BX648018


GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for XPNPEP3 (see all 7 )

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:                                -     -                 -                       -                                       
SP2:                                -     -           -     -                       -                                       
SP3:                                -     -           -     -                                                               
SP4:                                                                                -     -     -                           
SP5:                                -     -                                                                                 

About this scheme

ECgene alternative splicing isoforms for XPNPEP3

1 Ensembl transcript including schematic representation:
ENST00000357137  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XPNPEP3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for XPNPEP3

1 / 2 / 3

13 probe-sets matching XPNPEP3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
88392_r_at2, 3 U95-D 1 1.00 1.00 0.59 1.07 AI311557 0.80 1.00 0.91 1

80955_at2, 3 U95-E 1 1.00 1.00 0.71 0.75 AI479803 1.00 1.00 1.00 1

67202_f_at2, 3 U95-E 1 1.00 1.00 0.05 1.50 AI292218 0.80 1.00 0.91 1
56277_at2, 3 U95-B 1 1.00 1.00 0.81 0.95 AI743845 1.00 1.00 1.00 1

51722_at2, 3 U95-B 2 0.94 0.94 0.15 0.77 AI635379 0.80 1.00 0.91 1

224188_s_at2, 3 U133-B 1 1.00 1.00 -- -- BC001208 0.60 1.00 0.82 1

227910_at2, 3 U133-B 1 1.00 1.00 -- -- AI635379 0.80 1.00 0.91 1

226501_at2, 3 U133-B 1 1.00 1.00 -- -- BE966628 0.60 1.00 0.82 1

220020_at2, 3 U133-A 1 1.00 1.00 -- -- NM_022098 0.60 1.00 0.82 1

224188_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

227910_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226501_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

220020_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  XPNPEP3 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CGACTGCACT

SOURCE GeneReport for Unigene cluster: Hs.529163

UniProtKB/Swiss-Prot: XPP3_HUMAN, Q9NQH7
Tissue specificity: Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more
abundant

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for XPNPEP3 gene from 5/19 species (see all 19 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
XPNPEP31   -- X-prolyl aminopeptidase (aminopeptidase P) 3, putative 90.6(n)
92.9(a)
481237  XM_538358.2  XP_538358.2 
chimpanzee
(Pan troglodytes)
XPNPEP31   -- X-prolyl aminopeptidase (aminopeptidase P) 3, putative 99.61(n)
99.61(a)
458859  XM_515152.2  XP_515152.2 
cow
(Bos taurus)
XPNPEP31   -- X-prolyl aminopeptidase (aminopeptidase P) 3, putative 88.36(n)
90.55(a)
539202  XM_585578.3  XP_585578.2 
rat
(Rattus norvegicus)
Xpnpep31   -- X-prolyl aminopeptidase (aminopeptidase P) 3, putative 87.74(n)
89.46(a)
685823  XM_001069460.1  XP_001069460.1 
mouse
(Mus musculus)
Xpnpep35 15 X-prolyl aminopeptidase (aminopeptidase P) 3, putative   -- BI076709 
About this table        Species with no ortholog for XPNPEP3

ENSEMBL Gene Tree for XPNPEP3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for XPNPEP3 gene
PEPD2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/298 NCBI SNPs in XPNPEP3 are shown (see all 298 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 96)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 22 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs121692031,2
F,H39652852(+) TCTTTC/TGGTGA 1 -- ut314Minor allele frequency- T:0.03EU EA WA 418
rs60022041,2
H39652542(+) GGGGGT/GTTTTT 1 -- ut31 ese34Minor allele frequency- G:0.00EU EA WA 418
--
rs31807851,2
F39653344(+) GCTTGA/GGCCTG 1 -- ut311Minor allele frequency- G:0.17MN 184
--
rs170022431,2
H39650423(+) TCACAA/CTTGAG 1 I/L mis1 ese37Minor allele frequency- C:0.00NA EU EA WA 534
--
rs31795481,2
F39653718(+) TACTCG/AGGAGG 1 -- ut311Minor allele frequency- A:0.26MN 184
rs18946581,2
C,F,H,O39594995(+) GTCCCA/GGAAAG 1 P/P syn1 ese3 trp35Minor allele frequency- G:0.01MN EU EA WA 602
rs57581141,2
H39612454(+) GGAAGC/TTGACA 1 L/L syn1 ese34Minor allele frequency- T:0.00EU EA WA 418
rs1383521,2
A,C,F,H,O39598871(+) GGAATG/TCCTAA 1 -- int112Minor allele frequency- T:0.34EU EA WA NA 1122
rs1383541,2
A,C,F,H,O39602089(+) AGAATC/TAGGAG 1 -- int110Minor allele frequency- N:0.00MN EU EA WA NA 994
rs72919011,2
A,C,F,H39597310(+) TCTCTC/AAAAAA 1 -- int1 trp38Minor allele frequency- A:0.04EU EA WA 836
About this table

HapMap Linkage Disequilibrium images for XPNPEP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

8 PubMed articles for XPNPEP3 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 63929 HGNC: 28052 AceView: LOC63929 Ensembl:ENSG00000196236 euGenes: HUgn63929
ECgene: XPNPEP3 H-InvDB: XPNPEP3
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for XPNPEP3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XPNPEP3-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for XPNPEP3 Antibodies for XPNPEP3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for XPNPEP3 Browse small molecules at Sigma-Aldrich
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 Recombinant & Natural Proteins  

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 shRNA in GFP-retroviral vector
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 Drugs for XPNPEP3
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