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Aliases & Descriptions for XPNPEP3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| APP3 1, 2, 3 | | EC 3.4.11.9 3 | | OTTHUMP00000028904 2 |
| | | Descriptions |
|---|
| Aminopeptidase P3 3 | | X-Pro aminopeptidase 3 3 | | X-prolyl aminopeptidase (aminopeptidase P) 3, putative 2 |
|
| | Search outside databases for aliases for XPNPEP3 gene |
Summaries for XPNPEP3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for XPNPEP3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.31-q13.33 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2XPNPEP3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P039583:
(about GC identifiers)
Start:
|
39,583,040 bp from pter |
End:
|
39,653,829 bp from pter |
Size:
|
70,790 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000022.9 NT_011520.11
| Proteins for XPNPEP3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: XPP3_HUMAN, Q9NQH7 (See
protein sequence)Recommended Name: Probable Xaa-Pro aminopeptidase 3 Size: 507 amino acids; 57034 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Secondary accessions: Q6I9V9 Q8NDA6 Q9BV27 Q9BVH0Alternative splicing: 3 isoforms: Q9NQH7-1 Q9NQH7-2 Q9NQH7-3 REFSEQ proteins: NP_071381.1
ENSEMBL proteins: ENSP00000349658
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: XPNPEP3 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for XPNPEP3: Assays for XPNPEP3: | Protein
Domains/ Families for XPNPEP3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NQH7
ProtoNet protein and cluster: Q9NQH7 1 Blocks protein family: IPB007865 Aminopeptidase P
UniProtKB/Swiss-Prot: XPP3_HUMAN, Q9NQH7Similarity: Belongs to the peptidase M24B family | Gene Function for XPNPEP3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC001208
Applied Biosystems Silencer® siRNAs for XPNPEP3
Sigma-Aldrich siRNA and siRNA Panels for XPNPEP3  Sigma-Aldrich shRNA for XPNPEP3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022098                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_022098                                  untagged cDNA clones in CMV expression vector (see all 3): BC001208 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_022098
UniProtKB/Swiss-Prot: XPP3_HUMAN, Q9NQH7Catalytic activity: Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptideEnzyme Number (IUBMB): EC 3.4.11.9 1 MGI phenotypic allele for Xpnpep3 (no phenotypes)
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for XPNPEP3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009987 | cellular process |
IEA | -- | About this table
|
Drugs & Compounds for XPNPEP3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for XPNPEP3 |
Browse Tocris compounds for XPNPEP3
|
Transcripts for XPNPEP3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC001208
Sigma-Aldrich siRNA and siRNA Panels for XPNPEP3  Sigma-Aldrich shRNA for XPNPEP3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_022098 REFSEQ mRNAs for XPNPEP3 gene: NM_022098.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_022098               OriGene GFP tagged cDNA clone in CMV expression vector: NM_022098                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_022098                                  untagged cDNA clones in CMV expression vector (see all 3): BC001208  Additional cDNA sequence: AK057119.1 AK301635.1 AK301758.1 AK310502.1 AK313770.1 AL365514.1 AL834310.1 BC001208.1 BC001681.2 BC004989.1 BC005331.1 BC011632.2 BC016735.1 BC023654.2 BC032537.1 BC045166.1 BC053556.1 BC062446.1 BX648018.1 CR456442.1 CR457396.1 22 DOTS entries: DT.205707 DT.97763705 DT.107910 DT.85105369 DT.105823 DT.92425919 DT.120649898 DT.121643852 DT.442197 DT.100017483 DT.100747943 DT.120649998 DT.100017002 DT.121643429 DT.100733032 DT.102829080 DT.113562 DT.120649917 DT.120649932 DT.95370228 DT.100813100 DT.100813103 24/235 AceView cDNA sequences (see all 235
):AI446638 BX119041 N43765 BU628809 BC053556 AI377541 BM980889 CA941832 CR456442 AA121920 BC023654 BQ446896 AI244347 BX108020 AL834310 AI373300 AA700729 BF195962 BU620669 BU584042 BC001681 BC037424 BC011632 AI052824
highest scoring ESTs for XPNPEP3:AI479803 AI743845 AA234193 AA234273 AA236366 AA312950 AA382300 AA665693 AA699699 AA743536 Unigene Cluster for XPNPEP3: X-prolyl aminopeptidase (aminopeptidase P) 3, putative Hs.529163 [show with all ESTs]Unigene Representative Sequence: BX648018
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for XPNPEP3 (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | |
| SP1: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for XPNPEP3
1 Ensembl transcript including schematic representation: ENST00000357137
|
Expression for XPNPEP3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| XPNPEP3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for XPNPEP3
1 / 2 / 3 13 probe-sets matching XPNPEP3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CGACTGCACT
SOURCE GeneReport for Unigene cluster: Hs.529163 UniProtKB/Swiss-Prot: XPP3_HUMAN, Q9NQH7Tissue specificity: Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant |
Orthologs for XPNPEP3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XPNPEP3 gene from 5/19 species (see all 19
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
XPNPEP31 |
-- |
X-prolyl aminopeptidase (aminopeptidase P) 3, putative |
90.6(n) 92.9(a) |
481237 XM_538358.2 XP_538358.2 |
chimpanzee (Pan troglodytes) |
XPNPEP31 |
-- |
X-prolyl aminopeptidase (aminopeptidase P) 3, putative |
99.61(n) 99.61(a) |
458859 XM_515152.2 XP_515152.2 |
cow (Bos taurus) |
XPNPEP31 |
-- |
X-prolyl aminopeptidase (aminopeptidase P) 3, putative |
88.36(n) 90.55(a) |
539202 XM_585578.3 XP_585578.2 |
rat (Rattus norvegicus) |
Xpnpep31 |
-- |
X-prolyl aminopeptidase (aminopeptidase P) 3, putative |
87.74(n) 89.46(a) |
685823 XM_001069460.1 XP_001069460.1 |
mouse (Mus musculus) |
Xpnpep35 |
15 |
X-prolyl aminopeptidase (aminopeptidase P) 3, putative |
-- |
BI076709 |
About this table Species with no ortholog for XPNPEP3
ENSEMBL Gene Tree for XPNPEP3 | Paralogs for XPNPEP3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for XPNPEP3 gene
- PEPD2
|
SNPs/Variants for XPNPEP3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for XPNPEP3 (up to first 250kb)
|
Disorders & Mutations for XPNPEP3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for XPNPEP3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for XPNPEP3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for XPNPEP3 gene: |
Search for XPNPEP3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing XPNPEP3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing XPNPEP3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XPNPEP3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for XPNPEP3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for XPNPEP3:

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Incremental update: 13 Oct 2009
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