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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XPNPEP2 Gene

protein-coding   GIFtS: 61
GCID: GC0XP128872

X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
 Explore 11 diseases affiliated with
XPNPEP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for XPNPEP2    

Aliases
for XPNPEP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
X-Prolyl Aminopeptidase (Aminopeptidase P) 2, Membrane-Bound1 2     MAmP1
Aminoacylproline Aminopeptidase2 3     X-Pro Aminopeptidase 22 3
Membrane-Bound Aminopeptidase P2 3     APP22
Membrane-Bound AmP2 3     Xaa-Pro Aminopeptidase 22
Membrane-Bound APP2 3     EC 3.4.11.93

External Ids:    HGNC: 128231   Entrez Gene: 75122   Ensembl: ENSG000001221217   OMIM: 3001455   UniProtKB: O438953   

Export aliases for XPNPEP2 gene to outside databases

Previous GC identifers: GC0XP123518 GC0XP125718 GC0XP126817 GC0XP127578 GC0XP128598 GC0XP128700 GC0XP118278


Summaries
for XPNPEP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for XPNPEP2:
Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation
products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread
fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound
and soluble form of this enzyme have been identified as products of two separate genes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895
Function: A metalloprotease that may play a role in the inflammatory process and other reactions produced in response
to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin

Gene Wiki entry for XPNPEP2


Genomic Views
for XPNPEP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XPNPEP2 gene promoter:
         GR   NF-1   GR-beta   MyoD   FOXD3   NF-kappaB   GATA-1   NF-kappaB2   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XPNPEP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for XPNPEP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPNPEP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq25

XPNPEP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPNPEP2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP128872:  view genomic region     (about GC identifiers)

Start:
 128,872,946 bp from pter      End:
 128,903,525 bp from pter
Size:
 30,580 bases      Orientation:
 plus strand

Proteins
for XPNPEP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895 (See protein sequence)
Recommended Name: Xaa-Pro aminopeptidase 2 precursor  
Size: 674 amino acids; 75625 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Homotrimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: A0AV16 O75994

Explore the universe of human proteins at neXtProt for XPNPEP2: NX_O43895

Post-translational modifications:

  • Heavily glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43895

    • XPNPEP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003390.4  
    ENSEMBL proteins: 
     ENSP00000360146   ENSP00000360147  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: XPNPEP2
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    Novus Biologicals XPNPEP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for XPNPEP2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS9375790
    GO:0031225anchored to membrane IEA--


    XPNPEP2 for ontologies           About GeneDecksing



    XPNPEP2 Antibody Products: 
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    Protein Domains /
    Families
    for XPNPEP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    XPNPEP2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001131 Peptidase_M24B_aminopep-P_CS
     IPR000587 Creatinase
     IPR000994 Pept_M24_structural-domain

    Graphical View of Domain Structure for InterPro Entry O43895

    ProtoNet protein and cluster: O43895

    UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895
    Similarity: Belongs to the peptidase M24B family


    Function
    for XPNPEP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895
    Function: A metalloprotease that may play a role in the inflammatory process and other reactions produced in response
    to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin
    Catalytic activity: Release of any N-terminal amino acid, including proline, that is linked to proline, even from a
    dipeptide or tripeptide

         Genatlas biochemistry entry for XPNPEP2:
    aminopeptidase P,75.49kDa,hydrolyzing N terminal imido bonds

    Enzyme Number (IUBMB): EC 3.4.11.91

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XPNPEP2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate XPNPEP2:
    hsa-miR-1265 hsa-miR-3607-3p hsa-miR-135b hsa-miR-4328 hsa-miR-3662 hsa-miR-337-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: XPNPEP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XPNPEP2 (see all 7)
    OriGene shRNA RFP: XPNPEP2
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for XPNPEP2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008237metallopeptidase activity IEA--
    GO:0046872metal ion binding IEA--


    XPNPEP2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for XPNPEP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein digestion and absorption
    		Protein digestion and absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for XPNPEP2):
        Protein digestion and absorption


    XPNPEP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XPNPEP2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for XPNPEP2 (ENSP000003601474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YARSENSP000003625764STRING: ENSP00000362576
    PITRM1ENSP000003703774STRING: ENSP00000370377
    PUF60ENSP000003220164STRING: ENSP00000322016
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0009987cellular process IEA--


    XPNPEP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for XPNPEP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for XPNPEP2

    2 HMDB Compounds for XPNPEP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    Manganesemanganese 7439-96-5--
    Search CenterWatch for drugs/clinical trials and news about XPNPEP2 / XPP2 

    Transcripts
    for XPNPEP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for XPNPEP2 gene: 
    NM_003399.5  

    Unigene Cluster for XPNPEP2:

    X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
    Hs.170499  [show with all ESTs]
    Unigene Representative Sequence: U90724
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371105 ENST00000371106(uc011mum.2 uc004eut.1)

    miRNA
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    hsa-miR-1265 hsa-miR-3607-3p hsa-miR-135b hsa-miR-4328 hsa-miR-3662 hsa-miR-337-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: XPNPEP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XPNPEP2 (see all 7)
    OriGene shRNA RFP: XPNPEP2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XPNPEP2
    Clone
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XPNPEP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPNPEP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPNPEP2

    Additional cDNA sequence: 

    AF086417.1 AK300954.1 BC126174.1 BC143901.1 U90724.2 

    3 DOTS entries:

    DT.99986069  DT.410965  DT.100760683 

    24/34 AceView cDNA sequences (see all 34):

    AF086417 CD518663 BU677870 AW275469 AI358577 BQ224207 AW275371 BX386511 
    AW204294 AI473757 AI912887 AW025328 BX386512 T24561 AW849140 AA778144 
    CD617071 AA040482 AI269228 AA341827 AW601930 CF529129 AA917912 W67831 

    GeneLoc Exon Structure


    Expression
    for XPNPEP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    XPNPEP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAGTCCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    XPNPEP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    OvaryPrimary FollicleGranulosa CellsOvary
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See XPNPEP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for XPNPEP2

    SOURCE GeneReport for Unigene cluster: Hs.170499

    UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895
    Tissue specificity: Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in
    brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary

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    In Situ
    Assay Products:     
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    Orthologs
    for XPNPEP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for XPNPEP2 gene from 7/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves XPNPEP21 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound less 67.17(n)
    65.45(a)    		   422137  XM_420139.3  XP_420139.3 
    lizard
    (Anolis carolinensis)    		 Reptilia XPNPEP26
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL343451.1(465193-506963)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc635282 similar to X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound less 73.68(n)   394007  BC054906.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ApepP3 aminopeptidase 40(a)
    (best of 2)    		   36B4   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATAPP16
    AT3G053506
    		 metallopeptidase M24-like protein
    		 34(a)
    32(a)
    		 1 ↔ many
    possible ortholog
    		 4(17326617-17330208)
    3(1526963-1533867)
    rice
    (Oryza sativa)    		 Liliopsida Os.252612 Oryza sativa (japonica cultivar-group) cDNA cloneJ013130G17, full insert sequence less 69.58(n)    AK120553.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ypdF6
    		 Xaa-Pro aminopeptidase
    		 23(a)
    		 possible ortholog
    		 Chromosome(2503569-2504654)


    ENSEMBL Gene Tree for XPNPEP2 (if available)
    TreeFam Gene Tree for XPNPEP2 (if available) 

    Paralogs
    for XPNPEP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for XPNPEP2 gene
    XPNPEP12  
    1 SIMAP similar gene for XPNPEP2 using alignment to 3 protein entries:     XPP2_HUMAN (see all proteins):
    XPNPEP1

    XPNPEP2 for paralogs           About GeneDecksing



    Genomic Variants
    for XPNPEP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/533 NCBI SNPs in XPNPEP2 are shown (see all 533)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1385369631,2
    		--128871277(+) TGAGGA/GGGCAT 1 -- us2k10--------
    rs1415591131,2
    		--128871382(+) AGTTAC/TTGAAT 1 -- us2k10--------
    rs1138729761,2
    		C,--128871481(+) CACTGA/GGCCAC 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1379628961,2
    		--128871547(+) CTTCAA/TAATGG 1 -- us2k10--------
    rs20922431,2
    		C,H--128871552(+) AAATGG/TCCTAT 1 -- us2k16Minor allele frequency- T:0.00NA EA NS 550
    rs20500111,2
    		C,F,O,A,H,--128871578(+) TGGATT/GGTTGA 1 -- us2k122Minor allele frequency- G:0.35MN NS EA NA WA CSA 2529
    rs1855648981,2
    		--128871745(+) TGCAGC/TGAACC 1 -- us2k10--------
    rs1908198591,2
    		--128871750(+) TGAACC/TGAGAA 1 -- us2k10--------
    rs1818955921,2
    		--128871770(+) GCACTC/TCACCC 1 -- us2k10--------
    rs1440424581,2
    		--128871773(+) CTCCAC/TCCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for XPNPEP2 (128872946 - 128903525 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for XPNPEP2
         1 CNV: 4172
    Human Gene Mutation Database (HGMD): XPNPEP2

    Locus Specific Mutation Databases (LSDB): XPNPEP2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XPNPEP2
    DNA2.0 Custom Variant and Variant Library Synthesis for XPNPEP2

    Disorders / Diseases
    for XPNPEP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    XPNPEP2 for disorders           About GeneDecksing

    OMIM gene information: 300145    OMIM disorders: --

    11 diseases for XPNPEP2:    About MalaCards
    angioedema induced by ace inhibitors    angioedema    premature ovarian failure    hereditary angioedema
    urticaria    pneumonia    tuberculosis    pancreatitis
    malaria    prostatitis    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for XPNPEP2:
    Urticaria
    Genetic Association Database (GAD): XPNPEP2
    Human Genome Epidemiology (HuGE) Navigator: XPNPEP2 (3 documents)

    Export disorders for XPNPEP2 gene to outside databases

    Publications
    for XPNPEP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for XPNPEP2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with XPNPEP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue distribution of human membrane-bound aminopeptidase P. (PubMed id 9375790)1, 2, 3, 9 Venema R.C.... Ryan J.W. (1997)
    2. Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25. (PubMed id 9628831)1, 3, 9 Sprinkle T.J....Ryan J.W. (1998)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. (PubMed id 16175507)1, 4 Duan Q.L....Rouleau G.A. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. (PubMed id 10894934)1, 9 Prueitt R.L....Zinn A.R. (2000)
    7. Genetic analysis of Factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema. (PubMed id 19178938)1, 9 Duan Q.L....Rouleau G.A. (2009)
    8. A functional XPNPEP2 promoter haplotype leads to reduc ed plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedem a. (PubMed id 21898657)1 Cilia La Corte A.L....Hooper N.M. (2011)
    9. Identification of genetic factors associated with sus ceptibility to angiotensin-converting enzyme inhibitors-induced cough. (PubMed id 21052031)1 Grilo A....SA!ez M.E. (2011)
    10. Sex-dependent and race-dependent association of XPNPE P2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. (PubMed id 20625347)1 Woodard-Grice A.V....Brown N.J. (2010)

    External Searches for XPNPEP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing XPNPEP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7512 HGNC: 12823 AceView: XPNPEP2 Ensembl:ENSG00000122121 euGenes: HUgn7512
    ECgene: XPNPEP2 Kegg: 7512 H-InvDB: XPNPEP2

    Other Databases showing XPNPEP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing XPNPEP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for XPNPEP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for XPNPEP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for XPNPEP2 gene:
    Search GeneIP for patents involving XPNPEP2

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