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XPNPEP2 Gene

protein-coding   GIFtS: 62
GCID: GC0XP128872

X-Prolyl Aminopeptidase (Aminopeptidase P) 2, Membrane-Bound

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
X-Prolyl Aminopeptidase (Aminopeptidase P) 2, Membrane-Bound1 2     X-Pro Aminopeptidase 22 3
Aminoacylproline Aminopeptidase2 3     AEACEI2 5
Membrane-Bound Aminopeptidase P2 3     APP22
Membrane-Bound AmP2 3     Xaa-Pro Aminopeptidase 22
Membrane-Bound APP2 3     EC 3.4.11.93
mAmP2 3     

External Ids:    HGNC: 128231   Entrez Gene: 75122   Ensembl: ENSG000001221217   OMIM: 3001455   UniProtKB: O438953   

Export aliases for XPNPEP2 gene to outside databases

Previous GC identifers: GC0XP123518 GC0XP125718 GC0XP126817 GC0XP127578 GC0XP128598 GC0XP128700 GC0XP118278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XPNPEP2 Gene:
Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen
degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of
the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound
forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.
(provided by RefSeq, Jul 2008)

GeneCards Summary for XPNPEP2 Gene:
XPNPEP2 (X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound) is a protein-coding gene. Diseases associated with XPNPEP2 include angioedema induced by ace inhibitors, and hereditary angioedema. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is XPNPEP1.

UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895
Function: A metalloprotease that may play a role in the inflammatory process and other reactions produced in
response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin

Gene Wiki entry for XPNPEP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the XPNPEP2 gene promoter:
         GR   NF-1   GR-beta   MyoD   FOXD3   NF-kappaB   GATA-1   NF-kappaB2   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXPNPEP2 promoter sequence
   Search Chromatin IP Primers for XPNPEP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XPNPEP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq25

XPNPEP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XPNPEP2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP128872:  view genomic region     (about GC identifiers)

Start:
128,872,946 bp from pter      End:
128,903,525 bp from pter
Size:
30,580 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895 (See protein sequence)
Recommended Name: Xaa-Pro aminopeptidase 2 precursor  
Size: 674 amino acids; 75625 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Homotrimer
Secondary accessions: A0AV16 O75994

Explore the universe of human proteins at neXtProt for XPNPEP2: NX_O43895

Explore proteomics data for XPNPEP2 at MOPED

Post-translational modifications: 

  • Heavily glycosylated1
  • Glycosylation2 at Asn35, Asn49, Asn65, Asn278, Asn291
  • Modification sites at PhosphoSitePlus

  • See XPNPEP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003390.4  
    ENSEMBL proteins: 
     ENSP00000360146   ENSP00000360147  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: X-prolyl aminopeptidase 2
    Aminopeptidases

    3 InterPro protein domains:
     IPR000994 Pept_M24_structural-domain
     IPR001131 Peptidase_M24B_aminopep-P_CS
     IPR000587 Creatinase_N

    Graphical View of Domain Structure for InterPro Entry O43895

    ProtoNet protein and cluster: O43895

    UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895
    Similarity: Belongs to the peptidase M24B family


    XPNPEP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPP2_HUMAN, O43895
    Function: A metalloprotease that may play a role in the inflammatory process and other reactions produced in
    response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin
    Catalytic activity: Release of any N-terminal amino acid, including proline, that is linked to proline, even from
    a dipeptide or tripeptide

         Genatlas biochemistry entry for XPNPEP2:
    aminopeptidase P,75.49kDa,hydrolyzing N terminal imido bonds

         Enzyme Number (IUBMB): EC 3.4.11.91

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008237metallopeptidase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    XPNPEP2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XPNPEP2
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    hsa-miR-1265 hsa-miR-3607-3p hsa-miR-135b hsa-miR-4328 hsa-miR-3662 hsa-miR-337-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidXPNPEP2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XPP2_HUMAN, O43895: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS9375790
    GO:0031225anchored component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    XPNPEP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XPNPEP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein digestion and absorption
    Protein digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for XPNPEP2):
        Protein digestion and absorption


    XPNPEP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XPNPEP2
    Interactions:

        Search GeneGlobe Interaction Network for XPNPEP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for XPNPEP2 (ENSP000003601474) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PITRM1ENSP000003703774STRING: ENSP00000370377
    DDX41ENSP000003303494STRING: ENSP00000330349
    RBM25ENSP000002619734STRING: ENSP00000261973
    SNRNP70ENSP000002214484STRING: ENSP00000221448
    SUB1ENSP000002650734STRING: ENSP00000265073
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    XPNPEP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XPNPEP2 (XPP2)

    2 HMDB Compounds for XPNPEP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for XPNPEP2 gene: 
    NM_003399.5  

    Unigene Cluster for XPNPEP2:

    X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
    Hs.170499  [show with all ESTs]
    Unigene Representative Sequence: U90724
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371105 ENST00000371106(uc011mum.2 uc004eut.1)
    miRNA
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    hsa-miR-1265 hsa-miR-3607-3p hsa-miR-135b hsa-miR-4328 hsa-miR-3662 hsa-miR-337-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidXPNPEP2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat XPNPEP2
      QuantiFast Probe-based Assays in human, mouse, rat XPNPEP2

    Additional mRNA sequence: 

    AF086417.1 AK300954.1 BC126174.1 BC143901.1 U90724.2 

    3 DOTS entries:

    DT.99986069  DT.410965  DT.100760683 

    Selected AceView cDNA sequences (see all 34):

    AI358577 AF086417 BQ224207 AW275469 BU677870 CD518663 AW275371 AW025328 
    BX386511 AI473757 AI912887 BX386512 AW204294 AA341827 AA040482 CD617071 
    AA778144 AA917912 AW849140 T24561 W67831 AW601930 AI269228 CF529129 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XPNPEP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGTCCCT
    XPNPEP2 Expression
    About this image


    XPNPEP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    XPNPEP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XPNPEP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170499

    UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895
    Tissue specificity: Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in
    brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for XPNPEP2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xpnpep21 , 5 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound1, 5 83.01(n)1
    81.43(a)1
      X (25.52 cM)5
    1707451  NM_133213.21  NP_573476.21 
     481087255 
    chicken
    (Gallus gallus)
    Aves XPNPEP21 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 67.17(n)
    65.45(a)
      422137  XM_420139.4  XP_420139.4 
    lizard
    (Anolis carolinensis)
    Reptilia XPNPEP26
    X-prolyl aminopeptidase (aminopeptidase P) 2, memb...
    62(a)
    1 ↔ 1
    GL343451.1(465193-509525)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia xpnpep21 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 62.81(n)
    62.1(a)
      100145559  XM_002940289.2  XP_002940335.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635282 similar to X-prolyl aminopeptidase (aminopeptidase more 73.68(n)   394007  BC054906.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ApepP3 aminopeptidase 40(a)
    (best of 2)
      36B4   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y45G5AM.23   -- 30(a)   V(4175738-4180963)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FRA16
    Protein involved in negative regulation of transcr...
    29(a)
    1 → many
    XII(81461-83710) YLL029W
    soybean
    (Glycine max)
    eudicotyledons BM092066.12   -- 74.46(n)    BM092066.1 
    rice
    (Oryza sativa)
    Liliopsida Os.252612 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.58(n)    AK120553.1 


    ENSEMBL Gene Tree for XPNPEP2 (if available)
    TreeFam Gene Tree for XPNPEP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for XPNPEP2 gene
    XPNPEP12  
    1 SIMAP similar gene for XPNPEP2 using alignment to 3 protein entries:     XPP2_HUMAN (see all proteins):
    XPNPEP1

    XPNPEP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for XPNPEP2 (see all 654)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385369631,2
    --128826809(+) TGAGGA/GGGCAT 1 -- us2k10--------
    rs1415591131,2
    --128826914(+) AGTTAC/TTGAAT 1 -- us2k10--------
    rs1138729761,2
    C,F--128827013(+) CACTGA/GGCCAC 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1379628961,2
    --128827079(+) CTTCAA/TAATGG 1 -- us2k10--------
    rs20922431,2
    C,H--128827084(+) AAATGG/TCCTAT 1 -- us2k16Minor allele frequency- T:0.00NA EA NS 550
    rs20500111,2
    C,F,O,A,H--128827110(+) TGGATT/GGTTGA 1 -- us2k122Minor allele frequency- G:0.35MN NS EA NA WA CSA 2529
    rs1855648981,2
    --128827277(+) TGCAGC/TGAACC 1 -- us2k10--------
    rs1908198591,2
    --128827282(+) TGAACC/TGAGAA 1 -- us2k10--------
    rs1818955921,2
    --128827302(+) GCACTC/TCACCC 1 -- us2k10--------
    rs1440424581,2
    --128827305(+) CTCCAC/TCCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for XPNPEP2 (128872946 - 128903525 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for XPNPEP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv424981CNV Loss16902084
    nsv528290CNV Gain19592680
    nsv526197CNV Gain19592680
    dgv2475e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): XPNPEP2
    Locus Specific Mutation Databases (LSDB): XPNPEP2

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300145   
    OMIM disorders: 300909  
    10 diseases for XPNPEP2:    
    About MalaCards
    angioedema induced by ace inhibitors    hereditary angioedema    angioedema    premature ovarian failure
    urticaria    pneumonia    tuberculosis    malaria
    pancreatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for XPNPEP2:
    Urticaria

    XPNPEP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): XPNPEP2
    Human Genome Epidemiology (HuGE) Navigator: XPNPEP2 (3 documents)

    Export disorders for XPNPEP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XPNPEP2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with XPNPEP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue distribution of human membrane-bound aminopeptidase P. (PubMed id 9375790)1, 2, 3, 9 Venema R.C.... Ryan J.W. (Biochim. Biophys. Acta 1997)
    2. Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25. (PubMed id 9628831)1, 3, 9 Sprinkle T.J....Ryan J.W. (Genomics 1998)
    3. Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. (PubMed id 20625347)1, 4 Woodard-Grice A.V....Brown N.J. (Pharmacogenet. Genomics 2010)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. (PubMed id 16175507)1, 4 Duan Q.L....Rouleau G.A. (Am. J. Hum. Genet. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. (PubMed id 10894934)1, 9 Prueitt R.L....Zinn A.R. (Cytogenet. Cell Genet. 2000)
    8. Genetic analysis of Factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema. (PubMed id 19178938)1, 9 Duan Q.L....Rouleau G.A. (J. Allergy Clin. Immunol. 2009)
    9. The development of a novel molecular assay examining the role of aminopeptidase P polymorphisms in acute hypotensive transfusion reactions. (PubMed id 23276181)1 Hui Y....Tormey C.A. (amp 2013)
    10. A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema. (PubMed id 21898657)1 Cilia La Corte A.L....Hooper N.M. (Hum. Mutat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7512 HGNC: 12823 AceView: XPNPEP2 Ensembl:ENSG00000122121 euGenes: HUgn7512
    ECgene: XPNPEP2 Kegg: 7512 H-InvDB: XPNPEP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for XPNPEP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for XPNPEP2 gene:
    Search GeneIP for patents involving XPNPEP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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