Aliases for XPNPEP2 Gene
External Ids for XPNPEP2 Gene
Previous GeneCards Identifiers for XPNPEP2 Gene
Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for XPNPEP2 Gene
XPNPEP2 (X-Prolyl Aminopeptidase 2) is a Protein Coding gene. Diseases associated with XPNPEP2 include Angioedema Induced By Ace Inhibitors and Atrophic Rhinitis. Among its related pathways are Collagen chain trimerization and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include hydrolase activity and aminopeptidase activity. An important paralog of this gene is XPNPEP1.
UniProtKB/Swiss-Prot for XPNPEP2 Gene
Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.