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Aliases & Descriptions for XPNPEP2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.4.11.9 3 | | OTTHUMP00000023987 2 | | mAmP 3 |
| | | Descriptions |
|---|
| Aminoacylproline aminopeptidase 2, 3 | | Membrane-bound APP 3 | | Membrane-bound AmP 3 | | Membrane-bound aminopeptidase P 3 | | X-Pro aminopeptidase 2 3 | X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2 | | X-prolyl aminopeptidase 2, membrane-bound 2 |
|
| | Search outside databases for aliases for XPNPEP2 genePrevious GC identifers: GC0XP123518 GC0XP125718 GC0XP126817 GC0XP127578 GC0XP128598 |
Summaries for XPNPEP2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for XPNPEP2: Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq] UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895Function: A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykininGene Wiki entry for XPNPEP2 |
Genomic Location for XPNPEP2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the XPNPEP2 gene 
Entrez Gene cytogenetic band: Xq25 Ensembl cytogenetic band: Xq25 HGNC cytogenetic band: Xq25XPNPEP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP128700:
(about GC identifiers)
Start:
|
128,700,627 bp from pter |
End:
|
128,731,206 bp from pter |
Size:
|
30,580 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011786.15
| Proteins for XPNPEP2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895 (See
protein sequence)Recommended Name: Xaa-Pro aminopeptidase 2 precursor Size: 674 amino acids; 75625 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Homotrimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: A0AV16 O75994Post-translational modifications:
Heavily glycosylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003390.4
ENSEMBL proteins: ENSP00000360146 ENSP00000360147
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: XPNPEP2 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0031225 | anchored to membrane |
IEA | -- | About this table
Antibodies for XPNPEP2: Assays for XPNPEP2: | Protein
Domains/ Families for XPNPEP2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43895
ProtoNet protein and cluster: O43895 UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895Similarity: Belongs to the peptidase M24B family | Gene Function for XPNPEP2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003399
Applied Biosystems Silencer® siRNAs for XPNPEP2
Sigma-Aldrich siRNA and siRNA Panels for XPNPEP2  Sigma-Aldrich shRNA for XPNPEP2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003399                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003399                                  untagged cDNA clone in CMV expression vector: NM_003399 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003399
UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895Function: A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykininCatalytic activity: Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptideEnzyme Number (IUBMB): EC 3.4.11.9 Genatlas biochemistry entry for XPNPEP2:aminopeptidase P,75.49kDa,hydrolyzing N terminal imido bonds5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for XPNPEP2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for XPNPEP2 (ENSP000003601473) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0009987 | cellular process |
IEA | -- | About this table
|
Drugs & Compounds for XPNPEP2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for XPNPEP2 |
Browse Tocris compounds for XPNPEP2
|
Transcripts for XPNPEP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003399
Sigma-Aldrich siRNA and siRNA Panels for XPNPEP2  Sigma-Aldrich shRNA for XPNPEP2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003399 REFSEQ mRNAs for XPNPEP2 gene: NM_003399.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003399               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003399                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003399                                  untagged cDNA clone in CMV expression vector: NM_003399  Additional cDNA sequence: AF086417.1 AK300954.1 BC126174.1 BC143901.1 U90724.2 3 DOTS entries: DT.99986069 DT.410965 DT.100760683 24/34 AceView cDNA sequences (see all 34
):BU677870 AW275469 AW275371 AI358577 AF086417 BQ224207 CD518663 BX386512 BX386511 AI912887 AI473757 AW204294 AW025328 CD617071 AW601930 AA778144 AA040482 AI269228 W67831 CF529129 T24561 AA341827 AW849140 AA917912
highest scoring ESTs for XPNPEP2:AA040482 AA341827 AA778144 AA917912 AF086417 AI269228 AI358577 AW025328 AW204294 AW275469 Unigene Cluster for XPNPEP2: X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound Hs.170499 [show with all ESTs]Unigene Representative Sequence: U90724
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000371105
ENST00000371106
|
Expression for XPNPEP2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| XPNPEP2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for XPNPEP2
1 / 2 / 3 5 probe-sets matching XPNPEP2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CAGAGTCCCT
SOURCE GeneReport for Unigene cluster: Hs.170499
Expression variation in blood from EXPOLDB for XPNPEP2 UniProtKB/Swiss-Prot: XPP2_HUMAN, O43895Tissue specificity: Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary |
Orthologs for XPNPEP2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XPNPEP2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for XPNPEP2
ENSEMBL Gene Tree for XPNPEP2 | Paralogs for XPNPEP2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for XPNPEP2 gene
- XPNPEP12
|
SNPs/Variants for XPNPEP2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for XPNPEP2 (up to first 250kb)
|
Disorders & Mutations for XPNPEP2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300145 Human Gene Mutation Database: XPNPEP2 Genetic Association Database: XPNPEP2 Human Genome Epidemiology Navigator: XPNPEP2 (1 document)
|
Medical News for XPNPEP2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for XPNPEP2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for XPNPEP2 gene (see all 20
):- Cloning and tissue distribution of human membrane-bound aminopeptidase P. (PubMed id 9375790)1, 2, 3, 4 Venema R.C.... Ryan J.W. (1997)
- Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25. (PubMed id 9628831)1, 2, 3 Sprinkle T.J....Ryan J.W. (1998)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)3, 4 Ross M.T.... Bentley D.R. (2005)
- A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. (PubMed id 16175507)3, 6 Duan Q.L....Rouleau G.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. (PubMed id 10894934)1, 3 Prueitt R.L....Zinn A.R. (2000)
- Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit. (PubMed id 18515364)3 Li X....Rao Z. (2008)
- Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P. (PubMed id 18158172)3 Drouet C....Adam A. (2008)
- Kinin-dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors. (PubMed id 17003818)3 Molinaro G....Chanard J. (2006)
- Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)3 Fu G.K....Stuve L.L. (2004)
|
Search for XPNPEP2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing XPNPEP2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing XPNPEP2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XPNPEP2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for XPNPEP2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for XPNPEP2:

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Incremental update: 13 Oct 2009
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