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XPNPEP1 Gene

protein-coding GIFtS: 59

GC10M111614

X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
(Previous name: X-prolyl aminopeptidase (aminopeptidase P)-like )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: XPNPEP, XPNPEPL1, XPNPEPL)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.11.9 ^³
OTTHUMP00000020457 ^²
OTTHUMP00000058856 ^²
SAMP ^², ⁵
XPNPEP ^²
XPNPEPL ^², ³, ⁵
XPNPEPL1 ^², ³
sAmp ^³

Descriptions
Aminoacylproline aminopeptidase ^³
Cytosolic aminopeptidase P ^³
Soluble aminopeptidase P ^³
X-Pro aminopeptidase 1 ^³
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble ^²
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (SAMP, XPNPEP, XPNPEPL) ^²
X-prolyl aminopeptidase (aminopeptidase P)-like ^¹, ²
X-prolyl aminopeptidase 1, soluble ^³

External Ids
HGNC: 12822¹
Entrez Gene: 7511²
UniProtKB: Q9NQW7³
Ensembl: ENSG00000108039⁷

Search outside databases for aliases for XPNPEP1 gene

Previous GC identifers: GC10M110517 GC10M110858 GC10M111755 GC10M111289

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for XPNPEP1:

X-prolyl aminopeptidase (EC 3.4.11.9) is a proline-specific metalloaminopeptidase that specifically

catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate

proline residue. Because of its specificity toward proline, it has been suggested that X-prolyl

aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides,

and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments,

thereby complementing the pancreatic peptidases. Deficiency of X-prolyl aminopeptidase results in

excretion of large amounts of imino-oligopeptides in urine (Blau et al., 1988 [PubMed

3141711]).[supplied by OMIM]

Gene Wiki entry for XPNPEP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XPNPEP1 gene

Entrez Gene cytogenetic band: 10q25.3 Ensembl cytogenetic band: 10q25.1 HGNC cytogenetic band: 10q25.3

XPNPEP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M111614: (about GC identifiers)

Start:	111,614,514 bp from pter
End:	111,673,259 bp from pter
Size:	58,746 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XPP1_HUMAN, Q9NQW7 (See protein sequence)

Recommended Name: Xaa-Pro aminopeptidase 1

Size: 623 amino acids; 69918 Da

Cofactor: Manganese

Subunit: Homodimer

Subcellular location: Cytoplasm (By similarity)

PDB structures from and Proteopedia :

3CTZ (3D)

Secondary accessions: O15250 Q53EX6 Q8N3Q0 Q96D23

Alternative splicing: 2 isoforms: Q9NQW7-1 Q9NQW7-2

REFSEQ proteins: NP_065116.2

ENSEMBL proteins:

ENSP00000358694 ENSP00000324011 ENSP00000385388 ENSP00000358697 ENSP00000358672 ENSP00000358675

ENSP00000358673

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for XPNPEP1 (Aminopeptidase P1/XPNPEP1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XPNPEP1)
	Human Recombinant Proteins from Abnova (XPNPEP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--

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Antibodies for XPNPEP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XPNPEP1
	R&D Systems Antibodies for XPNPEP1 (Aminopeptidase P1/XPNPEP1)
	Antibodies from Abcam (XPNPEP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XPNPEP1)
	Novus Biologicals Antibodies for XPNPEP1

Assays for XPNPEP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NQW7

ProtoNet protein and cluster: Q9NQW7

UniProtKB/Swiss-Prot: XPP1_HUMAN, Q9NQW7

Similarity: Belongs to the peptidase M24B family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XPNPEP1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020383

Applied Biosystems Silencer® siRNAs for XPNPEP1

Sigma-Aldrich siRNA and siRNA Panels for XPNPEP1

Sigma-Aldrich shRNA for XPNPEP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XPNPEP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020383
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020383
untagged cDNA clones in CMV expression vector (see all 3): NM_020383

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020383

UniProtKB/Swiss-Prot: XPP1_HUMAN, Q9NQW7

Catalytic activity: Release of any N-terminal amino acid, including proline, that is linked to

proline, even from a dipeptide or tripeptide

Enzyme regulation: Inhibited by apstatin and the metal ion chelators EDTA and 1,10-phenanthroline.

Partially inhibited by dithiothreitol. Not inhibited by enalaprilat or amastatin

Biophysicochemical properties: Kinetic parameters: KM=100.6 uM for bradykinin; pH dependence:

Optimum pH is 8.2;

Enzyme Number (IUBMB): EC 3.4.11.9

1 MGI phenotypic allele for Xpnpep1 (no phenotypes)

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004177	aminopeptidase activity	IDA	11106490
GO:0008233	peptidase activity	IEA	--
GO:0008235	metalloexopeptidase activity	IEA	--
GO:0030145	manganese ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for XPNPEP1 (ENSP00000358694³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AXIN2	ENSP00000302625³	STRING (score=.829)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IDA	11106490
GO:0009987	cellular process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for XPNPEP1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XPNPEP1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XPNPEP1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020383

Sigma-Aldrich siRNA and siRNA Panels for XPNPEP1

Sigma-Aldrich shRNA for XPNPEP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020383

REFSEQ mRNAs for XPNPEP1 gene:

NM_020383.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020383

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020383
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020383
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_020383

Additional cDNA sequence:

AF195530.1 AF272981.1 AK093693.1 AK094900.1 AK095447.1 AK223513.1 AK289436.1 AK295756.1

AK304367.1 AL833411.1 BC005126.2 BC007579.1 BC013417.2 CR456922.1 X95762.1

24/32 DOTS entries (see all 32 ):

DT.100823571 DT.75189613 DT.100000241 DT.91997702 DT.100823568 DT.100823584 DT.121260882 DT.95070191

DT.92451275 DT.70100934 DT.92451279 DT.100823575 DT.100030385 DT.425887 DT.92451268 DT.92451280

DT.95364598 DT.100714100 DT.100823574 DT.102827189 DT.121260879 DT.121260881 DT.121260918 DT.121260953

24/425 AceView cDNA sequences (see all 425 ):

CA397671 CB242088 NM_020383 CA443428 AU280754 AL833411 BM716439 CA416745

AA307464 BQ668892 BM833684 T06411 BM728623 AI250783 AA453985 AA379196

BM470524 X95762 CA437752 T08900 BQ008771 CA412486 BU501976 AL519931

highest scoring ESTs for XPNPEP1:

AK093693 AL522068 AL523078 AL540060 AL833411 BC007579 BE279011 BE279542 BE732975 BE741806

Unigene Cluster for XPNPEP1:

X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

Hs.390623 [show with all ESTs]

Unigene Representative Sequence: AK095447

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for XPNPEP1 (see all 13 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12	^	13a	·	13b	·	13c	^	14	^	15a	·	15b	^	16a	·	16b	^
SP1:													-												-		-						-												-						-
SP2:													-												-		-						-												-						-
SP3:							-		-				-		-										-		-						-												-						-
SP4:																																	-												-
SP5:																																													-						-

ExUns:	17a	·	17b	·	17c	^	18a	·	18b	·	18c	·	18d	^	19	^	20	^	21	^	22	^	23
SP1:	-		-				-		-				-
SP2:	-		-		-		-		-				-
SP3:	-		-				-		-				-
SP4:
SP5:	-		-				-

About this scheme

ECgene alternative splicing isoforms for XPNPEP1

7 Ensembl transcripts including schematic representations:

ENST00000369680 ENST00000322238 ENST00000403138 ENST00000369683 ENST00000369658 ENST00000369661

ENST00000369659

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XPNPEP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XPNPEP1

¹ / ² / ³

8 probe-sets matching XPNPEP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35305_at²^{, 3}	U95-A	1	1.00	1.00	0.82	0.92	X95762	0.80	1.00	0.91	1
52172_at²^{, 3}	U95-C	1	1.00	1.00	0.82	1.08	AI250783	0.60	1.00	0.82	1
209045_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF195530	0.60	1.00	0.82	1
236239_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW609310	0.40	1.00	0.76	1
208453_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006523	0.20	1.00	0.72	1
209045_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
236239_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208453_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks XPNPEP1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGACTATATT

SOURCE GeneReport for Unigene cluster: Hs.390623
Expression variation in blood from EXPOLDB for XPNPEP1
UniProtKB/Swiss-Prot: XPP1_HUMAN, Q9NQW7
Tissue specificity: Expressed in all tissues tested, including pancreas, heart, muscle, kidney,
liver, lung and brain. Highest levels in pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XPNPEP1 gene from 5/27 species (see all 27 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XPNPEP1¹	--	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	93.26(n) 98.23(a)	486880 XM_544010.2 XP_544010.2
chimpanzee (Pan troglodytes)	XPNPEP1¹	--	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	99.46(n) 99.84(a)	450726 XM_508027.2 XP_508027.2
cow (Bos taurus)	XPNPEP1¹	--	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	92.44(n) 97.59(a)	513156 NM_001075602.1 NP_001069070.1
rat (Rattus norvegicus)	Xpnpep1¹	--	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	87.8(n) 95.67(a)	170751 NM_131913.1 NP_571988.1
mouse (Mus musculus)	Xpnpep1^{1, 5}	19⁵	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble^{1, 5}	88.18(n)¹ 95.83(a)¹	170750¹ NM_133216.2¹ NP_573479.2¹ AF363970⁵ AI852589⁵ (see all 30)

About this table Species with no ortholog for XPNPEP1

ENSEMBL Gene Tree for XPNPEP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XPNPEP1 gene

XPNPEP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/288 NCBI SNPs in XPNPEP1 are shown (see all 288 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 116)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7834^1,2	A,C,F,H	111614759(-)	`AAACAC/TTCAGT`	1	--	ut3¹		5	MN EU EA WA	602
	rs10884917^1,2	A,F,H	111674515(+)	`GTATTC/GTTCCC`	1	--	ng3¹ trp³		4	EU EA WA	418
	rs12249470^1,2	F,H	111675074(+)	`GAGAGA/GTAAGT`	1	--	ng3¹ trp³		4	EU EA WA	418
	rs17126844^1,2	F,H	111614131(+)	`GAGTCG/ACAGGC`	1	--	ng5¹		7	NA EU EA WA	558
	rs2145942^1,2	H	111614330(+)	`TATTAG/TGTTTT`	1	--	ng5¹		4	EU EA WA	408
	rs713545^1,2	H	111664796(+)	`ACCTCG/CTTAGG`	1	--	ut5¹ ese³		7	NA EA EU WA	664
	rs536343^1,2	A,C,F,H,O	111622869(+)	`AGCTAT/CTATAT`	1	--	int¹		3	EA WA	266
	rs944966^1,2	A,C,F,H,O	111648324(+)	`GAAAGG/CTGTGA`	1	--	int¹ trp³		18	EU EA WA NA	3056
	rs472049^1,2	A,C,F,H,O	111637728(+)	`CGAGGC/TTGGAG`	1	--	int¹		11	EA NA EU WA	676
	rs1889303^1,2	A,C,F,H,O	111649444(+)	`TCTGAT/ATCATG`	1	--	int¹		7	EU EA WA NA	560

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HapMap Linkage Disequilibrium images for XPNPEP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602443

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/18 PubMed articles for XPNPEP1 gene (see all 18 ):

Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P). (PubMed id 9465902)^{1, 3, 4} Vanhoof G.... Scharpe S. (1997)
Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2. (PubMed id 10871044)^{1, 3, 4} Sprinkle T.J.... Ryan J.W. (2000)
Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme. (PubMed id 11106490)^{1, 3, 4} Cottrell G.S.... Turner A.J. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7511	HGNC: 12822	AceView: XPNPEP1	Ensembl:ENSG00000108039	euGenes: HUgn7511
ECgene: XPNPEP1	H-InvDB: XPNPEP1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for XPNPEP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XPNPEP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XPNPEP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XPNPEP1		Antibodies for XPNPEP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XPNPEP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Drugs for XPNPEP1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for XPNPEP1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
XPNPEP1 Gene at Home site.
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XPNPEP1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for XPNPEP1

Summaries
for XPNPEP1

Genomic Location
for XPNPEP1

Proteins
for XPNPEP1

Protein Domains/
Families
for XPNPEP1

Gene Function
for XPNPEP1

Pathways & Interactions
for XPNPEP1

Drugs & Compounds
for XPNPEP1

Transcripts
for XPNPEP1

Expression
for XPNPEP1

Orthologs
for XPNPEP1

Paralogs
for XPNPEP1

SNPs/Variants
for XPNPEP1

Disorders & Mutations
for XPNPEP1

Medical News
for XPNPEP1

Publications
for XPNPEP1

Search for XPNPEP1

Genome Databases showing XPNPEP1

Other Databases showing XPNPEP1

Specialized Databases showing XPNPEP1

Licensable Technologies
for XPNPEP1

Services
for XPNPEP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XPNPEP1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor XPNPEP1

Summariesfor XPNPEP1

Genomic Locationfor XPNPEP1

Proteinsfor XPNPEP1

Protein Domains/Familiesfor XPNPEP1

Gene Functionfor XPNPEP1

Pathways & Interactionsfor XPNPEP1

Drugs & Compoundsfor XPNPEP1

Transcriptsfor XPNPEP1

Expression for XPNPEP1

Orthologsfor XPNPEP1

Paralogsfor XPNPEP1

SNPs/Variantsfor XPNPEP1

Disorders & Mutationsfor XPNPEP1

Medical Newsfor XPNPEP1

Publicationsfor XPNPEP1

Search for XPNPEP1

Genome Databases showing XPNPEP1

Other Databases showing XPNPEP1

Specialized Databases showing XPNPEP1

Licensable Technologiesfor XPNPEP1

Servicesfor XPNPEP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XPNPEP1

Summaries
for XPNPEP1

Genomic Location
for XPNPEP1

Proteins
for XPNPEP1

Protein Domains/
Families
for XPNPEP1

Gene Function
for XPNPEP1

Pathways & Interactions
for XPNPEP1

Drugs & Compounds
for XPNPEP1

Transcripts
for XPNPEP1

Expression
for XPNPEP1

Orthologs
for XPNPEP1

Paralogs
for XPNPEP1

SNPs/Variants
for XPNPEP1

Disorders & Mutations
for XPNPEP1

Medical News
for XPNPEP1

Publications
for XPNPEP1

Licensable Technologies
for XPNPEP1

Services
for XPNPEP1