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XPC Gene

protein-coding GIFtS: 71

GC03M014161

xeroderma pigmentosum, complementation group C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
XP3 ^²
XPCC ^¹, ², ³, ⁵
p125 ^³

Descriptions
Xeroderma pigmentosum group C-complementing protein ^³
xeroderma pigmentosum group C protein ^²
xeroderma pigmentosum, complementation group C ^²

External Ids
HGNC: 12816¹
Entrez Gene: 7508²
UniProtKB: Q01831³
Ensembl: ENSG00000154767⁷

Search outside databases for aliases for XPC gene

Previous GC identifer: GC03M014115

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XPC:

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple

components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne

syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an

important role in the early steps of global genome NER, especially in damage recognition, open

complex formation, and repair protein complex formation. Mutations in this gene or some other NER

components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by

increased sensitivity to sunlight with the development of carcinomas at an early age.

Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: XPC_HUMAN, Q01831

Function: Involved in DNA excision repair. May play a part in DNA damage recognition and/or in

altering chromatin structure to allow access by damage-processing enzymes

Gene Wiki entry for XPC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XPC gene

Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25

XPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M014161: (about GC identifiers)

Start:	14,161,648 bp from pter
End:	14,195,143 bp from pter
Size:	33,496 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XPC_HUMAN, Q01831 (See protein sequence)

Recommended Name: DNA repair protein complementing XP-C cells

Size: 940 amino acids; 105981 Da

Subunit: Heterodimer of a 125 kDa subunit (p125) and of a 58 kDa subunit (p58). Interacts with

CETN2

Subcellular location: Nucleus (Probable)

PDB structures from and Proteopedia :

2A4J (3D)

2GGM (3D)

2OBH (3D)

Secondary accessions: Q53GT7 Q96AX0

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001139241.1 NP_004619.3

ENSEMBL proteins:

ENSP00000285021

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XPC)
	Human Recombinant Proteins from Abnova (XPC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	10214908

About this table

Antibodies for XPC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XPC
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (XPC), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XPC)
	Novus Biologicals Antibodies for XPC

Assays for XPC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q01831

ProtoNet protein and cluster: Q01831

1 Blocks protein family: IPB004583 DNA repair protein Rad4

UniProtKB/Swiss-Prot: XPC_HUMAN, Q01831

Similarity: Belongs to the XPC family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XPC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XPC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004628

Applied Biosystems Silencer® siRNAs for XPC

Sigma-Aldrich siRNA and siRNA Panels for XPC

Sigma-Aldrich shRNA for XPC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145769
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145769
untagged cDNA clones in CMV expression vector (see all 2): NM_001145769

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004628

UniProtKB/Swiss-Prot: XPC_HUMAN, Q01831

Function: Involved in DNA excision repair. May play a part in DNA damage recognition and/or in

altering chromatin structure to allow access by damage-processing enzymes

Genatlas biochemistry entry for XPC:

component p125 (125kDa) of genome overall nucleotide excision repair complex,in tight association

with UBE3B (RAD23B)

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Xpc):

cellular	growth/size	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	skin/coat/nails	tumorigenesis	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003684	damaged DNA binding	TAS	10873465
GO:0003697	single-stranded DNA binding	TAS	8168482
GO:0005515	protein binding	IPI	15231747 18024891

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for XPC (Your Favorite Gene powered by Ingenuity)

Nucleotide Excision Repair Pathway

GeneDecks XPC for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for XPC

5/42 Interacting proteins for XPC (Q01831^{1, 2} ENSP00000285021³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OGG1	O15527², ENSP00000306561³	MINT-3292209 STRING (score=.907)
LSM3	P62310¹	EBI-372610, EBI-348239
BGLF4 BGLF4 (xeno)	Q777D1¹	EBI-372610, EBI-1630636
SMAD1	Q15797²	MINT-61986
ZNF512B	Q96KM6²	MINT-60797

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	IMP	17088560
GO:0000718	nucleotide-excision repair, DNA damage removal	EXP	10583946
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0010224	response to UV-B	IEA	--
GO:0031573	intra-S DNA damage checkpoint	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XPC
10 Novoseek chemical compound relationships for XPC gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
poly a-t	82.51	2	15886698 (1), 15863269 (1)
2-acetylaminofluorene	44.15	4	11376686 (1), 10029060 (1)
benzo(a)pyrene	38.88	3	17900831 (2), 19428948 (1)
tyrosine	28.56	27	8910389 (3), 7681835 (3), 8955182 (2), 7929090 (2) (see all 17)
wortmannin	26.12	1	8955182 (1)
thymine	13.40	1	12505994 (1)
atp	0.00	2	9698541 (1)
oligonucleotide	0.00	1	17355181 (1)
calcium	0.00	2	16627479 (1), 16750384 (1)
nadph	0.00	1	14688016 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XPC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XPC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004628

Sigma-Aldrich siRNA and siRNA Panels for XPC

Sigma-Aldrich shRNA for XPC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004628

REFSEQ mRNAs for XPC gene (2 alternative transcripts):

NM_001145769.1 NM_004628.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004628

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145769
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145769
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001145769

Additional cDNA sequence:

AK222844.1 AK289761.1 AK295711.1 AK311039.1 BC016620.1 CR615074.1 D21089.1 X65024.1

16 DOTS entries:

DT.213627 DT.97809299 DT.100027621 DT.120920057 DT.92033093 DT.75137024 DT.100796427 DT.95081053

DT.120919961 DT.120919988 DT.120920001 DT.95236198 DT.95236202 DT.99954142 DT.99988460 DT.120920007

24/238 AceView cDNA sequences (see all 238 ):

AI983317 BU506961 AU125870 BQ892451 AI091587 BE221715 AU120699 AL710884

CA435788 CR615074 CA748472 CF129648 CD619031 CB269927 BM827376 BX957075

BU631737 BE278952 AU130155 BF591481 BX476794 BF732301 AW295314 AI671844

highest scoring ESTs for XPC:

D21089 AL709045 AL710884 AU120699 AU128095 AW084643 AW504862 BC016620 BG259049 BI670281

Unigene Cluster for XPC:

Xeroderma pigmentosum, complementation group C

Hs.475538 [show with all ESTs]

Unigene Representative Sequence: NM_004628

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for XPC (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^
SP1:																															-
SP2:
SP3:																			-		-
SP4:																	-		-		-
SP5:									-

ExUns:	15a	·	15b	^	16a	·	16b	^	17a	·	17b
SP1:			-		-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for XPC

1 Ensembl transcript including schematic representation:

ENST00000285021

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XPC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XPC

¹ / ² / ³

3 probe-sets matching XPC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1873_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D21089	1.00	1.00	1.00	1
209375_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D21089	1.00	1.00	1.00	1
209375_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.475538
Expression variation in blood from EXPOLDB for XPC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XPC gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XPC¹	--	xeroderma pigmentosum, complementation group C	84.44(n) 79.49(a)	476521 XM_533727.2 XP_533727.2
cow (Bos taurus)	XPC¹	--	xeroderma pigmentosum, complementation group C	77.89(n) 75.7(a)	524274 XM_602596.3 XP_602596.3
rat (Rattus norvegicus)	Xpc¹	--	xeroderma pigmentosum, complementation group C	80.58(n) 76.48(a)	312560 XM_232194.3 XP_232194.2
mouse (Mus musculus)	Xpc^{1, 5}	6⁵	xeroderma pigmentosum, complementation group C^{1, 5}	79.37(n)¹ 75.49(a)¹	22591¹ NM_009531.2¹ NP_033557.2¹ AB071144⁵ AK004713⁵ (see all 15)
chicken (Gallus gallus)	XPC¹	--	xeroderma pigmentosum, complementation group C	63.24(n) 60.28(a)	416039 XM_414379.2 XP_414379.2

About this table Species with no ortholog for XPC

ENSEMBL Gene Tree for XPC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/261 NCBI SNPs in XPC are shown (see all 261 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 145)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2229090^1,2	A,C,F,H	14162346(-)	`GGGGGC/GTTCTC`	1	--	ut3¹ ese³		12	MN NS EA CSAM EU WA	2498
	rs1126547^1,2	A,C,F,H	14161758(-)	`TAGATC/GAGTGT`	1	--	ut3¹		9	NS MN NA EU EA WA	920
	rs2228001^1,2	A,C,F,H	14162450(-)	`TTGAGA/CAGCTG`	1	K/Q	mis¹ ese³		27	MN NS EA CSAM NA EU WA	3752
	rs2227999^1,2	C,F,H	14174910(-)	`CCATCG/ATAAGG`	1	H/R	mis¹		18	MN NS EU EA WA CSAM NA	1616
	rs3731062^1,2	C,F,H	14189528(-)	`GCCTTC/TTCTCC`	1	L/F	mis¹ ese³ trp³		9	NS EU EA WA	1012
	rs6413541^1,2	C,F,H	14174854(-)	`GAGGCA/CAGAAA`	1	K/Q	mis¹ ese³		9	MN CSAM EA EU WA	826
	rs2228000^1,2	C,F,H	14174889(-)	`GCCAGC/TGGCAT`	1	A/V	mis¹ ese³		15	MN NS EU EA WA CSAM	1472
--	rs3731177^1,2	C,F,H	14162483(-)	`AAAAGA/CAAGCA`	1	K/Q	mis¹ trp³		5	NS EU EA WA	582
	rs12487240^1,2	C,H	14162176(+)	`CTGTAG/TCTCAA`	1	--	ut3¹ ese³		4	EU EA WA	418
	rs3731187^1,2	F,H	14161364(-)	`TGAAAG/AAGTCC`	1	--	ng5¹		5	NS EU EA WA	594

About this table

HapMap Linkage Disequilibrium images for XPC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 278720

UniProtKB/Swiss-Prot: XPC_HUMAN, Q01831

Defects in XPC are a cause of xeroderma pigmentosum complementation group C (XP-C)

[MIM:278720]; also known as xeroderma pigmentosum III (XP3). XP-C is a rare human autosomal

recessive disease characterized by solar sensitivity, high predisposition for developing cancers

on areas exposed to sunlight and, in some cases, neurological abnormalities

10/26 Novoseek disease relationships for XPC gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
xeroderma pigmentosum	95.20	72	15964821 (2), 17693435 (2), 16105547 (2), 16627479 (2) (see all 54)
xeroderma pigmentosum, complementation group e	84.25	1	19382146 (1)
skin cancer	74.28	19	8994835 (2), 10749125 (2), 11376686 (2), 15863269 (2) (see all 12)
xeroderma	72.27	3	15863269 (1), 17355181 (1), 18177054 (1)
cockayne syndrome	68.29	1	9415314 (1)
skin tumor	50.37	1	12173040 (1)
li-fraumeni syndrome	50.17	1	12242345 (1)
bladder cancer	40.00	17	17052994 (5), 14688016 (2), 15886698 (2), 17510383 (2) (see all 7)
genetic susceptibility	39.03	1	16965652 (1)
cancer	37.99	12	18771913 (3), 16081512 (2), 16965652 (1), 15746160 (1) (see all 8)

About this table

Genatlas disease: XPC

xeroderma pigmentosum,group C (common form),with associated TP53 mutations in skin and internal

tumors (glioma)

GeneTests: XPC

Xeroderma Pigmentosum

Human Gene Mutation Database: XPC
Genetic Association Database: XPC
Human Genome Epidemiology Navigator: XPC (98 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/282 PubMed articles for XPC gene (see all 282 ):

Expression cloning of a human DNA repair gene involved in Xeroderma pigmentosum group C. (PubMed id 1522891)^{2, 3, 4} Legerski R.J. and Peterson C.A. (1992)
Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair. (PubMed id 16533048)^{1, 3, 4} Yang A....Craescu C.T. (2006)
The XPC poly-AT polymorphism in non-melanoma skin cancer. (PubMed id 15863269)^{1, 3, 6} Nelson H.H....Karagas M.R. (2005)
Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes. (PubMed id 11872635)^{1, 3, 6} Qiao Y....Wei Q. (2002)
[Polymorphisms in nucleotide excision repair genes XPC and XPD and clinical responses to platinum-based chemotherapy in advanced non-small cell lung cancer] (PubMed id 16061005)^{1, 3, 6} Yuan P....Lin D.X. (2005)
Single nucleotide polymorphisms for DNA repair genes in breast cancer patients. (PubMed id 16002061)^{1, 3, 6} Zhang L....Yan W. (2005)
Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer. (PubMed id 15837542)^{1, 3, 6} Vogel U....Raaschou-Nielsen O. (2005)
The polyAT, intronic IVS11-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder. (PubMed id 15886698)^{1, 3, 6} Sak S.C....Kiltie A.E. (2005)
Single nucleotide polymorphisms in breast cancer. (PubMed id 15010895)^{1, 3, 6} Forsti A....Kumar R. (2004)
Poly (AT) polymorphism in intron 11 of the XPC DNA repair gene enhances the risk of lung cancer. (PubMed id 15533908)^{1, 3, 6} Marin M.S....Tardon A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7508	HGNC: 12816	AceView: XPC	Ensembl:ENSG00000154767	euGenes: HUgn7508
ECgene: XPC	H-InvDB: XPC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for XPC	Genetics and Cytogenetics in Oncology and Haematology
Allelic variations of the XP genes	http://www.xpmutations.org/
GeneReviews	http://www.genetests.org/query?gene=XPC
NIEHS-SNPs	http://egp.gs.washington.edu/data/xpc/

Licensable Technologies for XPC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XPC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XPC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XPC		Antibodies for XPC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XPC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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XPC Gene at Home site.
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XPC Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for XPC

Summaries
for XPC

Genomic Location
for XPC

Proteins
for XPC

Protein Domains/
Families
for XPC

Gene Function
for XPC

Pathways & Interactions
for XPC

Drugs & Compounds
for XPC

Transcripts
for XPC

Expression
for XPC

Orthologs
for XPC

Paralogs
for XPC

SNPs/Variants
for XPC

Disorders & Mutations
for XPC

Medical News
for XPC

Publications
for XPC

Search for XPC

Genome Databases showing XPC

Other Databases showing XPC

Specialized Databases showing XPC

Licensable Technologies
for XPC

Services
for XPC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XPC Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor XPC

Summariesfor XPC

Genomic Locationfor XPC

Proteinsfor XPC

Protein Domains/Familiesfor XPC

Gene Functionfor XPC

Pathways & Interactionsfor XPC

Drugs & Compoundsfor XPC

Transcriptsfor XPC

Expression for XPC

Orthologsfor XPC

Paralogsfor XPC

SNPs/Variantsfor XPC

Disorders & Mutationsfor XPC

Medical Newsfor XPC

Publicationsfor XPC

Search for XPC

Genome Databases showing XPC

Other Databases showing XPC

Specialized Databases showing XPC

Licensable Technologiesfor XPC

Servicesfor XPC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XPC

Summaries
for XPC

Genomic Location
for XPC

Proteins
for XPC

Protein Domains/
Families
for XPC

Gene Function
for XPC

Pathways & Interactions
for XPC

Drugs & Compounds
for XPC

Transcripts
for XPC

Expression
for XPC

Orthologs
for XPC

Paralogs
for XPC

SNPs/Variants
for XPC

Disorders & Mutations
for XPC

Medical News
for XPC

Publications
for XPC

Licensable Technologies
for XPC

Services
for XPC