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XPA Gene

protein-coding GIFtS: 71

GC09M099477

xeroderma pigmentosum, complementation group A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000021751 ^²
XP1 ^¹, ²
XPAC ^¹, ², ³, ⁵

Descriptions
Xeroderma pigmentosum group A-complementing protein ^³
excision repair-controlling ^²
xeroderma pigmentosum, complementation group A ^²

External Ids
HGNC: 12814¹
Entrez Gene: 7507²
UniProtKB: P23025³
Ensembl: ENSG00000136936⁷

Search outside databases for aliases for XPA gene

Previous GC identifers: GC09M091262 GC09M092180 GC09M093874 GC09M095817 GC09M097516

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XPA:

This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is

part of the NER (nucleotide excision repair) complext which is responsible for repair of UV

radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this

gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced

transcript variants have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: XPA_HUMAN, P23025

Function: Involved in DNA excision repair. Initiates repair by binding to damaged sites with

various affinities, depending on the photoproduct and the transcriptional state of the region.

Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane

pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation

Gene Wiki entry for XPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XPA gene

Entrez Gene cytogenetic band: 9q22.3 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.3

XPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M099477: (about GC identifiers)

Start:	99,477,012 bp from pter
End:	99,499,512 bp from pter
Size:	22,501 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XPA_HUMAN, P23025 (See protein sequence)

Recommended Name: DNA repair protein complementing XP-A cells

Size: 273 amino acids; 31368 Da

Subunit: Interacts with XAB1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1D4U (3D)

1XPA (3D)

2JNW (3D)

Secondary accessions: Q5T1U9 Q6LCW7 Q6LD02

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000371.1

ENSEMBL proteins:

ENSP00000364270 ENSP00000364268

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XPA)
	Human Recombinant Proteins from Abnova (XPA)

OriGene Purified Recombinant Human Protein: XPA

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	1601884
GO:0005654	nucleoplasm	EXP	10214908

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Antibodies for XPA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XPA
	R&D Systems Antibodies for XPA
	Antibodies from Abcam (XPA), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XPA)
	Novus Biologicals Antibodies for XPA

Assays for XPA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P23025

ProtoNet protein and cluster: P23025

1 Blocks protein family: IPB000465 XPA protein

UniProtKB/Swiss-Prot: XPA_HUMAN, P23025

Similarity: Belongs to the XPA family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XPA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XPA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000380

Applied Biosystems Silencer® siRNAs for XPA

Sigma-Aldrich siRNA and siRNA Panels for XPA

Sigma-Aldrich shRNA for XPA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XPA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000380
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000380
untagged cDNA clone in CMV expression vector: NM_000380

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000380

UniProtKB/Swiss-Prot: XPA_HUMAN, P23025

Function: Involved in DNA excision repair. Initiates repair by binding to damaged sites with

various affinities, depending on the photoproduct and the transcriptional state of the region.

Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane

pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation

Genatlas biochemistry entry for XPA:

complementing repair defect in UV irradiated xeroderma pigmentation group A cells,yeast RAD14

homolog

15/20 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Xpa) (see all 20 ):

adipose tissue	behavior/neurological	cellular	craniofacial	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	limbs/digits/tail	liver/biliary system	muscle	nervous system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003684	damaged DNA binding	TAS	10946233
GO:0008270	zinc ion binding	IEA	--
GO:0019904	protein domain specific binding	IPI	17720715
GO:0042803	protein homodimerization activity	IPI	8197175

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for XPA (Your Favorite Gene powered by Ingenuity)

Nucleotide Excision Repair Pathway

GeneDecks XPA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for XPA

5/47 Interacting proteins for XPA (P23025¹ ENSP00000364270³) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XAB2	Q9HCS7¹, ENSP00000351137³	EBI-295222, EBI-295232 STRING (score=.927)
GPN1	Q9HCN4¹	EBI-295222, EBI-745137
ERCC1	ENSP00000013807³	STRING (score=.999)
ERCC5	ENSP00000347978³	STRING (score=.999)
RPA2	ENSP00000363015³	STRING (score=.999)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000718	nucleotide-excision repair, DNA damage removal	EXP	10583946
GO:0006974	response to DNA damage stimulus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XPA
10 Novoseek chemical compound relationships for XPA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cpds	59.04	3	11705987 (1), 11278856 (1)
benzo(a)pyrene	41.57	2	17900831 (2)
zinc	36.04	34	1339397 (4), 9761477 (3), 7526200 (3), 10783332 (3) (see all 11)
psoralen	34.92	2	16678501 (1), 11972036 (1)
2-acetylaminofluorene	31.05	4	15882075 (1)
cobalt	13.60	1	9761477 (1)
cadmium	8.05	8	10783332 (3), 17512921 (2)
oligonucleotide	2.59	2	10405289 (1), 11062174 (1)
sulfur	0.67	1	9761477 (1)
atp	0.00	5	9034344 (1), 9698541 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XPA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XPA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000380

Sigma-Aldrich siRNA and siRNA Panels for XPA

Sigma-Aldrich shRNA for XPA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000380

REFSEQ mRNAs for XPA gene:

NM_000380.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000380

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000380
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000380
                                 untagged cDNA clone in CMV expression vector: NM_000380

Additional cDNA sequence:

AK021661.1 BC014965.1 BT019518.1 CR601727.1 CR624117.1 D14533.1

10 DOTS entries:

DT.111331 DT.100639812 DT.100749805 DT.97785246 DT.111332 DT.97826676 DT.75107830 DT.100021004

DT.97798745 DT.95179165

24/82 AceView cDNA sequences (see all 82 ):

CB155090 D14533 CR624117 CR601727 CB305774 NM_000380 AI961077 BM468458

BQ001163 AA242764 BC014965 CA454341 AA453544 AI949886 CA450156 BI668635

AW275112 AI632135 BQ186624 BI793276 AI634902 BM853017 AU118563 AA167098

highest scoring ESTs for XPA:

D14533 BC014965 BE925040 BG681644 BG760044 BG831383 BI600681 BI668635 BI911749 BM468458

Unigene Cluster for XPA:

Xeroderma pigmentosum, complementation group A

Hs.654364 [show with all ESTs]

Unigene Representative Sequence: AK021661

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000375128 ENST00000375126

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XPA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XPA

¹ / ² / ³

5 probe-sets matching XPA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1307_at²^{, 3}	U95-A	1	1.00	1.00	0.53	1.21	D14533	1.00	1.00	1.00	1
1308_g_at²^{, 3}	U95-A	1	1.00	1.00	0.32	1.05	D14533	1.00	1.00	1.00	1
1995_at*²^{, 3}	U95-A	1	--	--	0.84	0.76	U16815	0.20	1.00	0.72	1
205672_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000380	0.60	1.00	0.82	1
205672_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks XPA for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTTTTTTAG

SOURCE GeneReport for Unigene cluster: Hs.654364
Expression variation in blood from EXPOLDB for XPA
UniProtKB/Swiss-Prot: XPA_HUMAN, P23025
Tissue specificity: Expressed in various cell lines and in skin fibroblasts

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XPA gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XPA¹	--	xeroderma pigmentosum, complementation group A	90.6(n) 93.41(a)	481623 XM_538745.2 XP_538745.2
chimpanzee (Pan troglodytes)	XPA¹	--	xeroderma pigmentosum, complementation group A	99.26(n) 99.12(a)	747191 XM_001156167.1 XP_001156167.1
cow (Bos taurus)	XPA¹	--	xeroderma pigmentosum, complementation group A	90.35(n) 91.58(a)	537958 NM_001038681.1 NP_001033770.1
rat (Rattus norvegicus)	Xpa¹	--	xeroderma pigmentosum, complementation group A	84.79(n) 88.97(a)	298074 XM_216403.3 XP_216403.2
mouse (Mus musculus)	Xpa^{1, 5}	4 (21.50 cM)⁵	xeroderma pigmentosum, complementation group A^{1, 5}	83.97(n)¹ 87.79(a)¹	22590¹ NM_011728.1¹ NP_035858.1¹ AF354052⁵ AI573865⁵ (see all 18)

About this table Species with no ortholog for XPA

ENSEMBL Gene Tree for XPA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/181 NCBI SNPs in XPA are shown (see all 181 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 130)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3176751^1,2	A,C,F,H	99477339(-)	`GTGCAC/GAATGT`	1	--	ut3¹		14	NS EU EA WA NA	1374
	rs3176757^1,2	A,C,F,H	99476879(-)	`AGGCAC/TTGATG`	1	--	ng5¹		28	NS EA NA EU WA	2412
	rs3176752^1,2	C,F,H	99477308(-)	`TACAAC/AAGAGA`	1	--	ut3¹ ese³		12	NS EU EA WA NA	1152
	rs3176750^1,2	C,F,H	99477610(-)	`AAAACC/GTAGAA`	1	L/V	mis¹ ese³		9	NS EU EA WA	1012
	rs3176753^1,2	C,F,H	99477264(-)	`GTAGGT/CCAGCT`	1	--	ut3¹		19	NS MN EU EA WA NA	1996
	rs3176758^1,2	C,F,H	99476587(-)	`TTGACA/GTGACA`	1	--	ng5¹		13	NS EU EA WA NA	808
	rs3176754^1,2	F,H	99477078(-)	`TGGAAA/GCAGTG`	1	--	ut3¹ ese³		5	NS EU EA WA	590
	rs10983315^1,2	C,H	99491737(+)	`CATAAC/TAGGTC`	1	V/I	mis¹		4	EU EA WA	404
	rs3176756^1,2	H	99476913(-)	`TTTCAT/CGGTTG`	1	--	ng5¹		5	NS EU EA WA	592
	rs3176749^1,2	H	99477664(-)	`GCAGCG/TTGTGG`	1	V/L	mis¹		5	NS EU EA WA	596

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HapMap Linkage Disequilibrium images for XPA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 611153 disorders: 278700

UniProtKB/Swiss-Prot: XPA_HUMAN, P23025

Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A)

[MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal

recessive disease characterized by solar sensitivity, high predisposition for developing cancers

on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show

the most severe skin symptoms and progressive neurological disorders

10/21 Novoseek disease relationships for XPA gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
xeroderma pigmentosum	96.41	119	1918083 (2), 10340474 (2), 1339397 (2), 9753735 (2) (see all 88)
trichothiodystrophy	77.43	1	11104904 (1)
xeroderma	76.43	4	10841197 (1), 15820060 (1), 15116327 (1)
cockayne syndrome	75.78	3	9415314 (1), 10601636 (1), 11104904 (1)
skin cancer	69.18	6	16905156 (1), 9415314 (1), 12509227 (1), 10602497 (1) (see all 5)
skin tumor	60.05	1	9180928 (1)
ataxia telangiectasia	35.50	2	16862173 (1), 16540648 (1)
cancer	33.84	15	11378441 (2), 11212280 (1), 16315315 (1), 15095299 (1) (see all 9)
carcinoma basal cell	30.80	1	15116327 (1)
cancer lung	27.18	12	15333465 (3), 16550608 (2), 15837542 (2), 15820060 (1) (see all 6)

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Genatlas disease: XPA

xeroderma pigmentosum,complementation group A

GeneTests: XPA

Xeroderma Pigmentosum

Human Gene Mutation Database: XPA
Genetic Association Database: XPA
Human Genome Epidemiology Navigator: XPA (51 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/280 PubMed articles for XPA gene (see all 280 ):

Molecular basis of group A Xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene. (PubMed id 1339397)^{1, 3, 4} Satokata I.... Okada Y. (1992)
Identification and characterization of xpac protein, the gene product of the human XPAC (Xeroderma pigmentosum group A complementing) gene. (PubMed id 1918083)^{1, 3, 4} Miura N.... Okada Y. (1991)
Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer. (PubMed id 15837542)^{1, 3, 6} Vogel U....Raaschou-Nielsen O. (2005)
UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. (PubMed id 19197159)^{1, 3, 4} Pan Y.R. and Lee E.Y. (2009)
Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. (PubMed id 15333465)^{1, 3, 6} Popanda O....Schmezer P. (2004)
Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA gene. (PubMed id 15598786)^{1, 3, 6} Butkiewicz D....Schmezer P. (2004)
Distribution of mutations in the human Xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein. (PubMed id 9671271)^{1, 3, 4} States J.C.... Cleaver J.E. (1998)
Analysis of a human DNA excision repair gene involved in group A Xeroderma pigmentosum and containing a zinc-finger domain. (PubMed id 2234061)^{1, 3, 4} Tanaka K.... Okada Y. (1990)
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)^{1, 3, 6} Zienolddiny S....Haugen A. (2006)
Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. (PubMed id 16393248)^{1, 3, 6} Sugimura T....Ishizaki K. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7507	HGNC: 12814	AceView: XPA	Ensembl:ENSG00000136936	euGenes: HUgn7507
ECgene: XPA	H-InvDB: XPA

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for XPA	Genetics and Cytogenetics in Oncology and Haematology
Allelic variations of the XP genes	http://www.xpmutations.org/
GeneReviews	http://www.genetests.org/query?gene=XPA
NIEHS-SNPs	http://egp.gs.washington.edu/data/xpa/

Licensable Technologies for XPA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XPA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XPA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XPA		Antibodies for XPA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XPA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (XPA)
	Antibodies (XPA)
	Chimera RNAi (XPA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (XPA)
	Antibodies (XPA)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for XPA

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XPA Gene at Home site.
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XPA Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for XPA

Summaries
for XPA

Genomic Location
for XPA

Proteins
for XPA

Protein Domains/
Families
for XPA

Gene Function
for XPA

Pathways & Interactions
for XPA

Drugs & Compounds
for XPA

Transcripts
for XPA

Expression
for XPA

Orthologs
for XPA

Paralogs
for XPA

SNPs/Variants
for XPA

Disorders & Mutations
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Medical News
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for XPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XPA Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor XPA

Summariesfor XPA

Genomic Locationfor XPA

Proteinsfor XPA

Protein Domains/Familiesfor XPA

Gene Functionfor XPA

Pathways & Interactionsfor XPA

Drugs & Compoundsfor XPA

Transcriptsfor XPA

Expression for XPA

Orthologsfor XPA

Paralogsfor XPA

SNPs/Variantsfor XPA

Disorders & Mutationsfor XPA

Medical Newsfor XPA

Publicationsfor XPA

Search for XPA

Genome Databases showing XPA

Other Databases showing XPA

Specialized Databases showing XPA

Licensable Technologiesfor XPA

Servicesfor XPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XPA

Summaries
for XPA

Genomic Location
for XPA

Proteins
for XPA

Protein Domains/
Families
for XPA

Gene Function
for XPA

Pathways & Interactions
for XPA

Drugs & Compounds
for XPA

Transcripts
for XPA

Expression
for XPA

Orthologs
for XPA

Paralogs
for XPA

SNPs/Variants
for XPA

Disorders & Mutations
for XPA

Medical News
for XPA

Publications
for XPA

Licensable Technologies
for XPA

Services
for XPA