XPA Gene
protein-coding GIFtS: 68
GCID: GC09M100437
|
|
xeroderma pigmentosum, complementation group A
| |
Aliases
for XPA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Xeroderma Pigmentosum, Complementation Group A1 2 | | XPAC1 2 3 5 | | XP11 2 | | Xeroderma Pigmentosum Group A-Complementing Protein2 3 | | DNA Repair Protein Complementing XP-A Cells2 | | Excision Repair-Controlling2 |
| External Ids: | HGNC: 128141 | Entrez Gene: 75072 | Ensembl: ENSG000001369367 | OMIM: 6111535 | UniProtKB: P230253 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n407779 | |
Export aliases for XPA gene to outside databasesPrevious GC identifers: GC09M091262 GC09M092180 GC09M093874 GC09M095817 GC09M097516 GC09M099477 GC09M070038
Summaries
for XPA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XPA:
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER(nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNAadducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosumcomplementation group A. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq,Mar 2009)
UniProtKB/Swiss-Prot: XPA_HUMAN, P23025Function: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities,depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UVirradiation
Gene Wiki entry for XPA
|
Genomic Views
for XPA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XPA gene promoter:
GR Max1 USF1 FOXD1 Lmo2 Tal-1beta USF-1 GR-alpha ITF-2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for XPA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q22.3 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.3XPA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M100437: view genomic region
(about GC identifiers)
Start:
|
100,437,191 bp from pter |
End:
|
100,459,691 bp from pter |
Size:
|
22,501 bases |
Orientation:
|
minus strand |
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Proteins
for XPA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XPA_HUMAN, P23025 (See
protein sequence)Recommended Name: DNA repair protein complementing XP-A cells Size: 273 amino acids; 31368 Da
Subunit: Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2
Subcellular location: Nucleus
3 PDB 3D structures from  and Proteopedia  for XPA:1D4U (3D)
1XPA (3D)
2JNW (3D)
Secondary accessions: Q5T1U9 Q6LCW7 Q6LD02Explore the universe of human proteins at neXtProt for XPA: NX_P23025
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
Ubiquitinated by HERC2 leading to degradation by the proteasome1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P23025
XPA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000371.1
ENSEMBL proteins: ENSP00000433006 ENSP00000364270 Reactome Protein details: P23025
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
XPA for ontologies About GeneDecksing
XPA Antibody Products:
Assay Products for XPA: |
Protein
Domains /
Families
for XPA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XPA for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P23025ProtoNet protein and cluster: P23025 1 Blocks protein family: IPB000465 XPA protein
UniProtKB/Swiss-Prot: XPA_HUMAN, P23025Similarity: Belongs to the XPA family |
Function
for XPA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XPA_HUMAN, P23025Function: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities,depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UVirradiation Genatlas biochemistry entry for XPA:complementing repair defect in UV irradiated xeroderma pigmentation group A cells,yeast RAD14 homolog
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XPA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XPA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XPA (NM_000380) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XPA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPA |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
XPA for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for XPA:
Animal Models:
Mouse knock-outs for XPA: Xpatm1Hvs Xpatm1Tnka
15/20 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Xpa) (see all 20):
XPA for phenotypes About GeneDecksing
|
Pathways & Interactions
for XPA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Global Genomic NER (GG-NER) | | | 2 | Transcription_P53 signaling pathway | | | 3 | Nucleotide Excision Repair | | | 4 | Chks in Checkpoint Regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for XPA
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for XPA
1  GeneGo (Thomson Reuters) Pathway for XPA
5 
Reactome Pathways for XPA
1 
Kegg Pathway (Kegg details for XPA):
XPA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XPA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/47 Interacting proteins for XPA (P230251, 3 ENSP000003642704) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000718 | nucleotide-excision repair, DNA damage removal |
TAS | -- | | GO:0006281 | DNA repair |
TAS | -- | | GO:0006289 | nucleotide-excision repair |
TAS | -- | | GO:0006979 | response to oxidative stress |
IEA | -- | | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
IEA | -- |
XPA for ontologies About GeneDecksing
|
Drugs & Compounds
for XPA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
XPA for compounds About GeneDecksing
 Browse Tocris compounds for XPA
10/16 Novoseek chemical compound relationships for XPA gene (see all 16) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cisplatin |
59.1 |
40 |
14563950 (5), 15820060 (4), 14676109 (3), 11163512 (3) (see all 16) |
| cpds |
57.8 |
3 |
11705987 (1), 11278856 (1) |
| oxaliplatin |
46.5 |
6 |
18204222 (3), 12504667 (1), 15213713 (1) |
| benzo(a)pyrene |
40.1 |
2 |
17900831 (2) |
| zinc |
34.1 |
34 |
1339397 (4), 9761477 (3), 7526200 (3), 10783332 (3) (see all 11) |
| psoralen |
33.2 |
2 |
16678501 (1), 11972036 (1) |
| 2-acetylaminofluorene |
29.9 |
4 |
15882075 (1) |
| mitomycin c |
15.3 |
13 |
17512921 (4), 11401562 (2), 16678501 (1) |
| cobalt |
11.4 |
1 |
9761477 (1) |
| cadmium |
5.82 |
8 |
10783332 (3), 17512921 (2) |
Search CenterWatch for drugs/clinical trials and news about XPA
|
Transcripts
for XPA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XPA gene: NM_000380.3 Unigene Cluster for XPA: Xeroderma pigmentosum, complementation group A Hs.654364 [show with all ESTs]Unigene Representative Sequence: NR_0273024 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000462523(uc004axs.4) ENST00000375128(uc004axr.4) ENST00000485042
ENST00000496104
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XPA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XPA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XPA (NM_000380) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XPA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPA |
Additional cDNA sequence: BC014965.1 BT019518.1 D14533.1 NR_027302.1 8 DOTS entries: DT.111331 DT.100639812 DT.100749805 DT.97826676 DT.100021004 DT.97798745 DT.111332 DT.75107830 24/82 AceView cDNA sequences (see all 82): CR601727 BC014965 BM468458 AA453544 AA242764 BQ001163 CR624117 AI949886 CB305774 CA450156 CB155090 D14533 NM_000380 CA454341 AI961077 AA903226 BF115636 AA167098 AI634902 AW196380 BE328895 AA242743 BM992090 AW044506
GeneLoc Exon Structure
|
Expression
for XPA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTTTTAG
About this image
See XPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XPA
SOURCE GeneReport for Unigene cluster: Hs.654364
UniProtKB/Swiss-Prot: XPA_HUMAN, P23025Tissue specificity: Expressed in various cell lines and in skin fibroblasts
SABiosciences Expression via Pathway-Focused PCR Arrays including XPA (see all 6): | DNA Damage Signaling Pathway in human mouse rat | | Oxidative Stress in human mouse rat | | Nitric Oxide Signaling Pathway in human mouse rat | | DNA Repair in human mouse rat | | Cancer Drug Resistance in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XPA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XPA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPA |
Orthologs
for XPA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for XPA gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Xpa1 , 5 |
xeroderma pigmentosum, complementation group A1, 5 |
83.84(n)1
87.4(a)1 |
|
4 (24.49 cM)5
225901 NM_011728.21 NP_035858.21
461553475 |
chicken
(Gallus gallus) |
Aves |
XPA1 |
xeroderma pigmentosum, complementation group A |
70.98(n)
70.2(a) |
|
395659 NM_204853.1 NP_990184.1 |
lizard
(Anolis carolinensis) |
Reptilia |
XPA6 |
-- |
72(a) |
1 ↔ 1 |
GL343544.1(104959-116677) |
African clawed frog
(Xenopus laevis) |
Amphibia |
XPAC2 |
xpacx1 protein |
75.35(n) |
|
D31894.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636402 |
hypothetical protein MGC63640 |
72.82(n) |
|
393443 BC055179.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Xpac1 , 3 |
nucleotide-excision repair3
Xeroderma pigmentosum group A-like1 |
42(a)3
50.79(n)1
46.15(a)1 |
|
1 4A53
313571 NM_057518.31 NP_476866.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
xpa-11 |
Protein XPA-1 |
54.04(n)
45.45(a) |
|
187120 NM_059624.1 NP_492025.1 |
ENSEMBL Gene Tree for XPA (if available)
TreeFam Gene Tree for XPA (if available) |
Paralogs
for XPA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for XPA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XPA (100437191 - 100459691 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for XPA: --
Human Gene Mutation Database (HGMD): XPA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XPA |
|
Disorders
/ Diseases
for XPA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XPA for disorders About GeneDecksing
OMIM gene information: 611153
OMIM disorders: 278700
UniProtKB/Swiss-Prot: XPA_HUMAN, P23025
Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known asxeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solarsensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurologicalabnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders
20/59  diseases for XPA (see all 59): About MalaCardsxeroderma pigmentosum xeroderma pigmentosum, group a multiple self healing squamous epithelioma xeroderma pigmentosum, type 1
photosensitive trichthiodystrophy nevoid basal cell carcinoma syndrome mutagen sensitivity non-hodgkin lymphoma
ataxia telangiectasia basal cell carcinoma cockayne syndrome autosomal recessive disease
esophageal squamous cell carcinoma squamous cell carcinoma myeloid leukemia hodgkin's lymphoma
male infertility germ cell tumor chronic myeloid leukemia acute myeloid leukemia
4 diseases from the University of Copenhagen DISEASES database for XPA:Xeroderma pigmentosum Cockayne syndrome Photosensitive trichothiodystrophy Skin cancer 10/21 Novoseek disease relationships for XPA gene (see all 21) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| xeroderma pigmentosum |
96.4 |
126 |
1918083 (2), 10340474 (2), 1339397 (2), 9753735 (2) (see all 93) |
| trichothiodystrophy |
76.4 |
1 |
11104904 (1) |
| xeroderma |
75.2 |
4 |
10841197 (1), 15820060 (1), 15116327 (1) |
| cockayne syndrome |
74.9 |
3 |
9415314 (1), 10601636 (1), 11104904 (1) |
| skin cancer |
68.4 |
6 |
16905156 (1), 9415314 (1), 12509227 (1), 10602497 (1) (see all 5) |
| skin tumor |
58.6 |
1 |
9180928 (1) |
| ataxia telangiectasia |
33.7 |
2 |
16862173 (1), 16540648 (1) |
| cancer |
33.2 |
15 |
11378441 (2), 11212280 (1), 16315315 (1), 15095299 (1) (see all 9) |
| carcinoma basal cell |
28.7 |
1 |
15116327 (1) |
| cancer lung |
24.8 |
12 |
15333465 (3), 16550608 (2), 15837542 (2), 15820060 (1) (see all 6) |
Genatlas disease: XPA xeroderma pigmentosum,complementation group A
GeneTests: XPA
Xeroderma Pigmentosum
Genetic Association Database (GAD): XPA
Human Genome Epidemiology (HuGE) Navigator: XPA (82 documents)
Export disorders for XPA gene to outside databases
|
Publications
for XPA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XPA gene, integrated from 9 sources (see all 340):
(articles sorted by number of sources associating them with XPA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular basis of group A Xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene. (PubMed id 1339397)1, 2, 9 Satokata I.... Okada Y. (1992)
- Identification and characterization of xpac protein, the gene product of the human XPAC (Xeroderma pigmentosum group A complementing) gene. (PubMed id 1918083)1, 2, 9 Miura N.... Okada Y. (1991)
- Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer. (PubMed id 15837542)1, 4, 9 Vogel U....Raaschou-Nielsen O. (2005)
- UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. (PubMed id 19197159)1, 2, 9 Pan Y.R. and Lee E.Y. (2009)
- Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. (PubMed id 15333465)1, 4, 9 Popanda O....Schmezer P. (2004)
- Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA gene. (PubMed id 15598786)1, 4, 9 Butkiewicz D....Schmezer P. (2004)
- Distribution of mutations in the human Xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein. (PubMed id 9671271)1, 2, 9 States J.C.... Cleaver J.E. (1998)
- Analysis of a human DNA excision repair gene involved in group A Xeroderma pigmentosum and containing a zinc-finger domain. (PubMed id 2234061)1, 2, 9 Tanaka K.... Okada Y. (1990)
- Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)1, 4, 9 Zienolddiny S....Haugen A. (2006)
- Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. (PubMed id 16393248)1, 4, 9 Sugimura T....Ishizaki K. (2006)
|
External Searches for XPA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing XPA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing XPA gene
(According to HUGE)
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Specialized Databases showing XPA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for XPA | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for XPA | Genetics and Cytogenetics in Oncology and Haematology | | Allelic variations of the XP genes | http://www.xpmutations.org/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/XPA | | NIEHS-SNPs | http://egp.gs.washington.edu/data/xpa/ | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt142.shtml |
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| Patent Information for XPA gene:
Search GeneIP for patents involving XPA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for XPA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XPA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XPA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XPA | | | OriGene Protein Over-expression Lysate for XPA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XPA | | OriGene 3'-UTR Clone for XPA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XPA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XPA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XPA | | OriGene Custom Protein Services for XPA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XPA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XPA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XPA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XPA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XPA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XPA |
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| | | | Search Tocris compounds for XPA |
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 | | | XPA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XPA |
|  |  |  | | | | ThermoFisher Antibodies for XPA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XPA |
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GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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