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XKRY2 Gene

protein-coding   GIFtS: 32

GC0YP018756
XK, Kell blood group complex subunit-related, Y-linked 2
(Previous names: X Kell blood group precursor-related, Y-linked pseudogene 7, X Kell blood group precursor-related, Y-linked 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: XKRYP7)
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Aliases &
Descriptions
for XKRY2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
XKRYP7 2
Descriptions
X Kell blood group precursor-related, Y-linked 2 1, 2
X Kell blood group precursor-related, Y-linked pseudogene 7 1, 2
XK, Kell blood group complex subunit-related, Y-linked 2 2
External Ids
HGNC: 239221
Entrez Gene: 3535152
UniProtKB: A2RUG33
Ensembl: ENSG000001979957
Search outside databases for aliases for XKRY2 gene

Previous GC identifer: GC0YM018318

Summaries
for XKRY2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for XKRY2:
This gene is located in the nonrecombining portion of the Y chromosome, and is expressed
specifically in testis. It encodes a protein which is similar to XK (X-linked Kell blood group
precursor), a putative membrane transport protein. This gene is present as two identical copies
within a palindromic region; this record represents the more telomeric copy. [provided by RefSeq]

Genomic Location
for XKRY2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XKRY2 gene  

Entrez Gene cytogenetic band: Yq11.221   Ensembl cytogenetic band:  Yq11.221   HGNC cytogenetic band: Yq11.221

XKRY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP018756:     (about GC identifiers)

Start:
 18,756,623 bp from pter
End:
 18,758,403 bp from pter
Size:
 1,781 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000024.8  NT_011875.11  

Proteins
for XKRY2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: XKRY2_HUMAN, A2RUG3 (See protein sequence)
Recommended Name: Testis-specific XK-related protein, Y-linked 2  
Size: 117 amino acids; 12988 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

REFSEQ proteins: NP_001002906.1  

ENSEMBL proteins: 
ENSP00000386081 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for XKRY2: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for XKRY2

Assays for XKRY2: 
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Protein Domains/
Families
for XKRY2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: A2RUG3

UniProtKB/Swiss-Prot: XKRY2_HUMAN, A2RUG3
Similarity: Belongs to the XK family

Gene Function
for XKRY2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001002906

              Applied Biosystems Silencer® siRNAs for XKRY2

              Sigma-Aldrich siRNA for XKRY2  
                     Sigma-Aldrich shRNA for XKRY2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001002906
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001002906
                                 untagged cDNA clone in CMV expression vector: NM_001002906 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001002906

Pathways & Interactions
for XKRY2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for XKRY2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XKRY2

Transcripts
for XKRY2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001002906

              Sigma-Aldrich siRNA for XKRY2  
                     Sigma-Aldrich shRNA for XKRY2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001002906  

REFSEQ mRNAs for XKRY2 gene: 

NM_001002906.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001002906  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001002906
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001002906
                                 untagged cDNA clone in CMV expression vector: NM_001002906 

Additional cDNA sequence: 

BC132901.1 BC132903.1 

1 DOTS entry:

DT.91743011 

3 AceView cDNA sequences:

NM_001002906 NM_004677 AF000997 

highest scoring ESTs for XKRY2:

NM_001002906 BC132883 BC132885 BC132901 BC132903 

Unigene Cluster for XKRY2:

XK, Kell blood group complex subunit-related, Y-linked 2
Hs.632286
Unigene Representative Sequence: NM_001002906


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000360402  

Expression
for XKRY2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XKRY2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for XKRY2

1 / 2 / 3

3 probe-sets matching XKRY2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

31415_at2, 3 U95-A 4 1.00 0.41 1.00 1.00 AF000997 0.60 0.40 0.51 2

208339_at2, 3 U133-A 4 1.00 0.44 -- -- NM_004677 0.20 0.33 0.27 2

208339_at2 U133Plus2 4 1.00 0.44 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GAGAAGGGTA

SOURCE GeneReport for Unigene cluster: Hs.632286

UniProtKB/Swiss-Prot: XKRY2_HUMAN, A2RUG3
Tissue specificity: Testis-specific

Orthologs
for XKRY2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

 ENSEMBL Gene Tree for XKRY2

Paralogs
for XKRY2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for XKRY2 gene
XKRY1  XK2  XKRX2  XKR32  

SNPs/Variants
for XKRY2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for XKRY2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for XKRY2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for XKRY2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for XKRY2 gene:

Search for XKRY2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing XKRY2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 353515 HGNC: 23922 AceView: XKRY2 Ensembl:ENSG00000197995 euGenes: HUgn353515
ECgene: XKRY2 H-InvDB: XKRY2

Other Databases showing XKRY2

(According to HUGE)
About This Section

   --

Specialized Databases showing XKRY2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for XKRY2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for XKRY2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for XKRY2:
 TaqMan ® Gene Expression Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XKRY2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for XKRY2 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for XKRY2 Browse small molecules at Sigma-Aldrich
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for XKRY2

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