XKRY Gene
protein-coding GIFtS: 35
GCID: GC0YM019880
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XK, Kell blood group complex subunit-related, Y-linked(Previous names: X Kell blood group precursor-related, Y-linked )
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Aliases
for XKRY gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| XK, Kell Blood Group Complex Subunit-Related, Y-Linked1 2 | | XKRY11 2 3 | | X Kell Blood Group Precursor-Related, Y-Linked1 2 | | Testis-Specific XK-Related Protein On Y2 | | Testis-Specific XK-Related Protein, Y-Linked 22 |
Export aliases for XKRY gene to outside databasesPrevious GC identifers: GC0YP019502 GC0YM019127 GC0YM018826 GC0YU900246 GC0YM018390 |
Summaries
for XKRY gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XKRY:
This gene is located in the nonrecombining portion of the Y chromosome, and is expressed specifically in testis. Itencodes a protein which is similar to XK (X-linked Kell blood group precursor), a putative membrane transport protein.This gene is present as two identical copies within a palindromic region; this record represents the more centromericcopy. (provided by RefSeq, Jul 2008)
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Genomic Views
for XKRY gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011875.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XKRY gene promoter:
SRF MEF-2 SRF (504 AA) CUTL1 E47 GATA-1 MEF-2A Hand1 Msx-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for XKRY
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKRY |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yq11.222 Ensembl cytogenetic band: Yq11.222 HGNC cytogenetic band: Yq11.221XKRY Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YM019880: view genomic region
(about GC identifiers)
Start:
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19,880,860 bp from pter |
End:
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19,889,280 bp from pter |
Size:
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8,421 bases |
Orientation:
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minus strand |
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Proteins
for XKRY gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XKRY_HUMAN, O14609 (See
protein sequence)Recommended Name: Testis-specific XK-related protein, Y-linked Size: 159 amino acids; 18083 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for XKRY: NX_O14609
XKRY Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_004668.2
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
XKRY for ontologies About GeneDecksing
XKRY Antibody Products:
Assay Products for XKRY: |
Protein
Domains /
Families
for XKRY gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O14609 UniProtKB/Swiss-Prot: XKRY_HUMAN, O14609Similarity: Belongs to the XK family |
Function
for XKRY gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKRY
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKRY
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XKRY (NM_004677) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKRY | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKRY |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKRY |
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Pathways & Interactions
for XKRY gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XKRY
1 Interacting protein for XKRY (O146093) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
XKRY for ontologies About GeneDecksing
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Drugs & Compounds
for XKRY gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XKRY
Search CenterWatch for drugs/clinical trials and news about XKRY
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Transcripts
for XKRY gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XKRY gene: NM_004677.2 Unigene Cluster for XKRY: XK, Kell blood group complex subunit-related, Y-linked Hs.158346 Unigene Representative Sequence: AF0009972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000510392 ENST00000354494
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKRY
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKRY
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XKRY (NM_004677) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKRY | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKRY |
Additional cDNA sequence: AF000997.1 BC132883.1 BC132885.1 1 DOTS entry: DT.91743011
GeneLoc Exon Structure
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Expression
for XKRY gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XKRY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAATATAA
About this image
Genevestigator expression for XKRY
SOURCE GeneReport for Unigene cluster: Hs.158346
UniProtKB/Swiss-Prot: XKRY_HUMAN, O14609Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for XKRY
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKRY
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat XKRY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKRY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKRY | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKRY |
Orthologs
for XKRY gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for XKRY (if available)
TreeFam Gene Tree for XKRY (if available) |
Paralogs
for XKRY gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XKRY gene
- XKRY2
3 SIMAP similar genes for XKRY using alignment to 1 protein entry: XKRY_HUMAN:XKRY2 XKR3 XKRX
XKRY for paralogs About GeneDecksing
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Genomic Variants
for XKRY gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for XKRY
1 CNV: 2287 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for XKRY gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XKRY for disorders About GeneDecksing
OMIM gene information: 400015
OMIM disorders: --
2  diseases for XKRY: About MalaCardsy chromosome infertility infertility
Export disorders for XKRY gene to outside databases
|
Publications
for XKRY gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XKRY gene integrated from 9 sources:
(articles sorted by number of sources associating them with XKRY) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2, 3 Lahn B.T. and Page D.C. (1997)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1 Skaletsky H.... Page D.C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Kell and Kx, two disulfide-linked proteins of the human erythrocyte membrane are phosphorylated in vivo. (PubMed id 9647734)1 Carbonnet F....Bertrand O. (1998)
- Y Chromosome Infertility (PubMed id 20301513)1 Disteche C.M. (1993)
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External Searches for XKRY gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing XKRY gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing XKRY gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XKRY gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for XKRY | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for XKRY gene:
Search GeneIP for patents involving XKRY
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XKRY gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XKRY | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XKRY | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKRY | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XKRY | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKRY | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKRY | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XKRY | | OriGene Custom Protein Services for XKRY | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XKRY | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XKRY | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKRY | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XKRY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKRY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKRY |
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 | | | XKRY Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKRY |
|  |  |  | | | | ThermoFisher Antibody for XKRY |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKRY |
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