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XKRX Gene

protein-coding GIFtS: 41

GC0XM100055

XK, Kell blood group complex subunit-related, X-linked
(Previous names: X Kell blood group precursor-related, X-linked )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ60646 ^²
XKR2 ^¹, ², ³, ⁵
XPLAC ^¹, ², ³, ⁵
XRG2 ^², ³, ⁵

Descriptions
Membrane protein XPLAC ^², ³
X Kell blood group precursor-related, X-linked ^¹, ²
X Kell blood group-related, X-linked ^³
XK, Kell blood group complex subunit-related, X-linked ^²

External Ids
HGNC: 29845¹
Entrez Gene: 402415²
UniProtKB: Q6PP77³
Ensembl: ENSG00000182489⁷

Search outside databases for aliases for XKRX gene

Previous GC identifers: GC0XM098942 GC0XM099974

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for XKRX:

XKRX and XKR3 (MIM 611674) are homologs of the Kell blood group precursor XK (MIM 314850), which is

a putative membrane transporter and a component of the XK/Kell complex of the Kell blood group

system (Calenda et al., 2006 [PubMed 16431037]).[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XKRX gene

Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22

XKRX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM100055: (about GC identifiers)

Start:	100,055,090 bp from pter
End:	100,070,554 bp from pter
Size:	15,465 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011651.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77 (See protein sequence)

Recommended Name: XK-related protein 2

Size: 449 amino acids; 52052 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: B2RNN6 B4DKU2 Q5H9J6

Alternative splicing: 2 isoforms: Q6PP77-1 Q6PP77-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_997724.2

ENSEMBL proteins:

ENSP00000362047 ENSP00000327570

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for XKRX:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for XKRX

Assays for XKRX:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6PP77

UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77

Similarity: Belongs to the XK family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKRX)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_212559

Applied Biosystems Silencer® siRNAs for XKRX

Sigma-Aldrich siRNA for XKRX

Sigma-Aldrich shRNA for XKRX

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_212559
Myc/DDK tagged cDNA clone in CMV expression vector: NM_212559
untagged cDNA clone in CMV expression vector: NM_212559

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_212559

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for XKRX (ENSP00000327570³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KEL	ENSP00000347409³	STRING (score=.89)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XKRX

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKRX)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_212559

Sigma-Aldrich siRNA for XKRX

Sigma-Aldrich shRNA for XKRX

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_212559

REFSEQ mRNAs for XKRX gene:

NM_212559.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_212559

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_212559
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_212559
                                 untagged cDNA clone in CMV expression vector: NM_212559

Additional cDNA sequence:

AK296711.1 AY534239.1 AY589511.1 BC137010.1 BC137011.1

1 DOTS entry:

DT.210873

16 AceView cDNA sequences:

AA257106 AY589511 NM_212559 AA856735 AI761820 BX116685 H87640 AI087330

BG675952 AA256009 BU682540 BF509819 AA648723 H87629 AA588027 H87641

highest scoring ESTs for XKRX:

AA213814 AY589511 AA256009 AA257106 AA588027 AA648723 AA856735 AI761820 AW968072 AW974230

Unigene Cluster for XKRX:

XK, Kell blood group complex subunit-related, X-linked

Hs.592216 [show with all ESTs]

Unigene Representative Sequence: AY589511

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000372956 ENST00000328526

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XKRX expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XKRX

¹ / ² / ³

3 probe-sets matching XKRX gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53524_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA213814	0.80	1.00	0.91	1
230349_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA213814	0.80	1.00	0.91	1
230349_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.592216
UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77
Tissue specificity: Expressed predominantly in the placenta, in syncythiotrophoblasts. Moderate
levels in the adrenal gland, low levels in the trachea and very low levels in the bone marrow

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XKRX gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XKRX¹	--	XK, Kell blood group complex subunit-related, X-linked	93.3(n) 94.26(a)	609590 XM_846877.1 XP_851970.1
chimpanzee (Pan troglodytes)	XKRX¹	--	XK, Kell blood group complex subunit-related, X-linked	99.93(n) 100(a)	473701 XM_529074.2 XP_529074.2
cow (Bos taurus)	XKRX¹	--	XK, Kell blood group complex subunit-related, X-linked	91.52(n) 93.58(a)	524975 XM_603316.2 XP_603316.2
rat (Rattus norvegicus)	Xkrx¹	--	XK, Kell blood group complex subunit-related, X-linked	90.48(n) 92.41(a)	497101 NM_001012230.1 NP_001012230.1
mouse (Mus musculus)	Xkrx^{1, 5}	X⁵	X Kell blood group precursor related X linked^{1, 5}	90.57(n)¹ 91.98(a)¹	331524¹ NM_183319.2¹ NP_899142.2¹ AK041635⁵ AK172064⁵ (see all 9)

About this table Species with no ortholog for XKRX

ENSEMBL Gene Tree for XKRX

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XKRX gene

XK² XKR3² XKRY2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/96 NCBI SNPs in XKRX are shown (see all 96 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7058487^1,2	F,H	100055859(+)	`GATAGG/TCTTAA`	1	--	ut3¹		4		EU EA WA	418
	rs1204414^1,2	H	100070075(-)	`CTGTTC/ACCAAA`	1	--	ut5¹ ese³		4		EU EA WA	418
	rs6652832^1,2	H	100056028(+)	`TCTGAG/ATTCTC`	1	N/N	syn¹ ese³		4		EU EA WA	418
	rs1204415^1,2	A,C,F,H,O	100069383(-)	`TTTGGC/GCTGTG`	1	--	int¹		9		EU EA WA NA	740
	rs916212^1,2	A,C,F,H,O	100067747(-)	`AAATGA/GAAACA`	1	--	int¹		7		EU EA WA NA	533
	rs1204418^1,2	A,C,F,H,O	100068258(-)	`ATTGCA/GAGAGA`	1	--	int¹		15		EU EA WA NA	1130
	rs1204417^1,2	A,C,F,H	100068747(-)	`ccaccG/Acgcct`	1	--	int¹		8		EU EA WA	628
	rs916211^1,2	A,C,F,H	100067959(-)	`CTTCCC/GCCTGT`	1	--	int¹ trp³		4		EU EA WA	418
--	rs11092287^1,2	A,C	100062925(+)	`tgatcC/Tgcctg`	1	--	int¹		0	--	--	--	--
--	rs5920874^1,2	A,C	100063624(+)	`CAGGCA/GCCTGC`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for XKRX (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300684

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for XKRX gene:

Identification of two new members, XPLAC and XTES, of the XK family. (PubMed id 16431037)^{3, 4} Calenda G.... Lee S. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 402415	HGNC: 29845	AceView: XKRX	Ensembl:ENSG00000182489	euGenes: HUgn402415
ECgene: XKRX	H-InvDB: XKRX

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for XKRX
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XKRX:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XKRX-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XKRX		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for XKRX		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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XKRX Gene at Home site.
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XKRX Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for XKRX

Summaries
for XKRX

Genomic Location
for XKRX

Proteins
for XKRX

Protein Domains/
Families
for XKRX

Gene Function
for XKRX

Pathways & Interactions
for XKRX

Drugs & Compounds
for XKRX

Transcripts
for XKRX

Expression
for XKRX

Orthologs
for XKRX

Paralogs
for XKRX

SNPs/Variants
for XKRX

Disorders & Mutations
for XKRX

Medical News
for XKRX

Publications
for XKRX

Search for XKRX

Genome Databases showing XKRX

Other Databases showing XKRX

Specialized Databases showing XKRX

Licensable Technologies
for XKRX

Services
for XKRX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XKRX Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor XKRX

Summariesfor XKRX

Genomic Locationfor XKRX

Proteinsfor XKRX

Protein Domains/Familiesfor XKRX

Gene Functionfor XKRX

Pathways & Interactionsfor XKRX

Drugs & Compoundsfor XKRX

Transcriptsfor XKRX

Expression for XKRX

Orthologsfor XKRX

Paralogsfor XKRX

SNPs/Variantsfor XKRX

Disorders & Mutationsfor XKRX

Medical Newsfor XKRX

Publicationsfor XKRX

Search for XKRX

Genome Databases showing XKRX

Other Databases showing XKRX

Specialized Databases showing XKRX

Licensable Technologiesfor XKRX

Servicesfor XKRX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XKRX

Summaries
for XKRX

Genomic Location
for XKRX

Proteins
for XKRX

Protein Domains/
Families
for XKRX

Gene Function
for XKRX

Pathways & Interactions
for XKRX

Drugs & Compounds
for XKRX

Transcripts
for XKRX

Expression
for XKRX

Orthologs
for XKRX

Paralogs
for XKRX

SNPs/Variants
for XKRX

Disorders & Mutations
for XKRX

Medical News
for XKRX

Publications
for XKRX

Licensable Technologies
for XKRX

Services
for XKRX