XKRX Gene
protein-coding GIFtS: 41
GCID: GC0XM100168
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XK, Kell blood group complex subunit-related, X-linked(Previous names: X Kell blood group precursor-related, X-linked )
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Aliases
for XKRX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| XK, Kell Blood Group Complex Subunit-Related, X-Linked1 2 | | X Kell Blood Group Precursor-Related, X-Linked1 2 | | XKR21 2 3 5 | | Membrane Protein XPLAC2 3 | | XPLAC1 2 3 5 | | XK-Related Protein 22 | | XRG22 3 5 | | X Kell Blood Group-Related, X-Linked3 |
Export aliases for XKRX gene to outside databasesPrevious GC identifers: GC0XM098942 GC0XM099974 GC0XM100055 GC0XM089966 |
Summaries
for XKRX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XKRX:
This gene encodes a protein that is related to a component of the XK/Kell complex of the Kell blood group system. Theencoded protein includes several transmembrane domains, is known to be exposed to the cell surface, and may functionas a membrane transporter. (provided by RefSeq, May 2010)
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Genomic Views
for XKRX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XKRX gene promoter:
HFH-1 FOXO1a POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 ITF-2 Tal-1beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for XKRX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKRX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22XKRX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM100168: view genomic region
(about GC identifiers)
Start:
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100,168,431 bp from pter |
End:
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100,184,422 bp from pter |
Size:
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15,992 bases |
Orientation:
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minus strand |
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Proteins
for XKRX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77 (See
protein sequence)Recommended Name: XK-related protein 2 Size: 449 amino acids; 52052 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAI37011.1; Type=Erroneous initiation; Sequence=AAI37012.1; Type=Erroneous initiation;Sequence=AAT00456.1; Type=Erroneous initiation; Sequence=AAT07088.1; Type=Erroneous initiation;
Secondary accessions: B2RNN6 B4DKU2 Q5H9J6Alternative splicing: 2 isoforms: Q6PP77-1 Q6PP77-2 Explore the universe of human proteins at neXtProt for XKRX: NX_Q6PP77
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PP77
XKRX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997724.2
ENSEMBL proteins: ENSP00000362047 ENSP00000419884 ENSP00000327570
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
XKRX for ontologies About GeneDecksing
XKRX Antibody Products:
Assay Products for XKRX: |
Protein
Domains /
Families
for XKRX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XKRX for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6PP77ProtoNet protein and cluster: Q6PP77 UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77Similarity: Belongs to the XK family |
Function
for XKRX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKRX (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKRX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XKRX (NM_212559) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKRX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKRX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKRX |
1 GenomeRNAi human phenotype for XKRX:
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Pathways & Interactions
for XKRX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XKRX
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for XKRX (Q6PP773 ENSP000003275704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for XKRX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XKRX
Search CenterWatch for drugs/clinical trials and news about XKRX / XKR2
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Transcripts
for XKRX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XKRX gene: NM_212559.2 Unigene Cluster for XKRX: XK, Kell blood group complex subunit-related, X-linked Hs.364911 [show with all ESTs]Unigene Representative Sequence: AY5895113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372956 ENST00000468904 ENST00000328526(uc004egn.2 uc011mre.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKRX (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKRX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XKRX (NM_212559) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKRX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKRX |
Additional cDNA sequence: AK296711.1 AY534239.1 AY589511.1 BC137010.1 BC137011.1 1 DOTS entry: DT.210873 16 AceView cDNA sequences: AA856735 NM_212559 AY589511 BX116685 AI761820 AA257106 H87640 BG675952 AA256009 BU682540 AI087330 BF509819 H87629 AA648723 AA588027 H87641
GeneLoc Exon Structure
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Expression
for XKRX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XKRX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See XKRX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XKRX
SOURCE GeneReport for Unigene cluster: Hs.364911
UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77Tissue specificity: Expressed predominantly in the placenta, in syncytiotrophoblasts. Moderate levels in the adrenalgland, low levels in the trachea and very low levels in the bone marrow
SABiosciences Custom PCR Arrays for XKRX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKRX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XKRX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKRX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKRX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKRX |
Orthologs
for XKRX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for XKRX gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for XKRX (if available)
TreeFam Gene Tree for XKRX (if available) |
Paralogs
for XKRX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XKRX gene
- XK2 XKR32
4 SIMAP similar genes for XKRX using alignment to 2 protein entries: XKR2_HUMAN (see all proteins):XK XKR3 XKRY2 XKRY
XKRX for paralogs About GeneDecksing
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Genomic Variants
for XKRX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XKRX (100168431 - 100184422 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for XKRX: --
Locus Specific Mutation Databases (LSDB): XKRX
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XKRX |
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Disorders
/ Diseases
for XKRX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 XKRX for disorders About MalaCards
XKRX for disorders About GeneDecksing
OMIM gene information: 300684
OMIM disorders: --
Export disorders for XKRX gene to outside databases
|
Publications
for XKRX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XKRX gene integrated from 9 sources:
(articles sorted by number of sources associating them with XKRX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of two new members, XPLAC and XTES, of the XK family. (PubMed id 16431037)1, 2 Calenda G.... Lee S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for XKRX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing XKRX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing XKRX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XKRX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for XKRX | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for XKRX gene:
Search GeneIP for patents involving XKRX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XKRX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XKRX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XKRX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKRX | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XKRX | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKRX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKRX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XKRX | | OriGene Custom Protein Services for XKRX | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XKRX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XKRX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKRX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XKRX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKRX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKRX |
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| | | | Search Tocris compounds for XKRX |
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 | | | XKRX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKRX |
|  |  |  | | | | Search ThermoFisher Antibodies for XKRX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKRX |
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