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Aliases for XKRX Gene

Aliases for XKRX Gene

  • XK, Kell Blood Group Complex Subunit-Related, X-Linked 2 3
  • XPLAC 3 4 6
  • XKR2 3 4 6
  • XRG2 3 4 6
  • X Kell Blood Group Precursor-Related, X-Linked 2 3
  • Membrane Protein XPLAC 3 4
  • X Kell Blood Group-Related, X-Linked 4
  • XK-Related Protein 2 3

External Ids for XKRX Gene

Summaries for XKRX Gene

Entrez Gene Summary for XKRX Gene

  • This gene encodes a protein that is related to a component of the XK/Kell complex of the Kell blood group system. The encoded protein includes several transmembrane domains, is known to be exposed to the cell surface, and may function as a membrane transporter. [provided by RefSeq, May 2010]

GeneCards Summary for XKRX Gene

XKRX (XK, Kell Blood Group Complex Subunit-Related, X-Linked) is a Protein Coding gene. An important paralog of this gene is XKR3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKRX Gene

Genomics for XKRX Gene

Genomic Location for XKRX Gene

Start:
100,913,442 bp from pter
End:
100,929,433 bp from pter
Size:
15,992 bases
Orientation:
Minus strand

Genomic View for XKRX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XKRX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKRX Gene

Regulatory Elements for XKRX Gene

Proteins for XKRX Gene

  • Protein details for XKRX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PP77-XKR2_HUMAN
    Recommended name:
    XK-related protein 2
    Protein Accession:
    Q6PP77
    Secondary Accessions:
    • B2RNN6
    • B4DKU2
    • Q5H9J6

    Protein attributes for XKRX Gene

    Size:
    449 amino acids
    Molecular mass:
    52052 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI37011.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37012.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT00456.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT07088.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for XKRX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XKRX Gene

Proteomics data for XKRX Gene at MOPED

Post-translational modifications for XKRX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKRX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKRX Gene

Domains for XKRX Gene

Protein Domains for XKRX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XKRX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PP77

UniProtKB/Swiss-Prot:

XKR2_HUMAN
Family:
  • Belongs to the XK family.:
    • Q6PP77
genes like me logo Genes that share domains with XKRX: view

No data available for Gene Families for XKRX Gene

Function for XKRX Gene

Phenotypes for XKRX Gene

GenomeRNAi human phenotypes for XKRX:
genes like me logo Genes that share phenotypes with XKRX: view

miRNA for XKRX Gene

miRTarBase miRNAs that target XKRX

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for XKRX Gene

Localization for XKRX Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKRX Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XKRX Gene COMPARTMENTS Subcellular localization image for XKRX gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for XKRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKRX: view

Pathways for XKRX Gene

SuperPathways for XKRX Gene

No Data Available

Interacting Proteins for XKRX Gene

Selected Interacting proteins: Q6PP77-XKR2_HUMAN for XKRX Gene via I2D

Symbol External ID(s) Details
MYC

Gene Ontology (GO) - Biological Process for XKRX Gene

None

No data available for Pathways by source for XKRX Gene

Transcripts for XKRX Gene

mRNA/cDNA for XKRX Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKRX Gene

XK, Kell blood group complex subunit-related, X-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XKRX Gene

No ASD Table

Relevant External Links for XKRX Gene

GeneLoc Exon Structure for
XKRX
ECgene alternative splicing isoforms for
XKRX

Expression for XKRX Gene

mRNA expression in normal human tissues for XKRX Gene

mRNA differential expression in normal tissues according to GTEx for XKRX Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (15.4) and Skin - Not Sun Exposed (Suprapubic) (11.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for XKRX Gene

SOURCE GeneReport for Unigene cluster for XKRX Gene Hs.745071

mRNA Expression by UniProt/SwissProt for XKRX Gene

Q6PP77-XKR2_HUMAN
Tissue specificity: Expressed predominantly in the placenta, in syncytiotrophoblasts. Moderate levels in the adrenal gland, low levels in the trachea and very low levels in the bone marrow.
genes like me logo Genes that share expressions with XKRX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for XKRX Gene

Orthologs for XKRX Gene

This gene was present in the common ancestor of chordates.

Orthologs for XKRX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XKRX 35
  • 100 (n)
  • 100 (a)
XKRX 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XKRX 35
  • 91.54 (n)
  • 93.54 (a)
XKRX 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XKRX 35
  • 93.24 (n)
  • 94.21 (a)
XKRX 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xkrx 35
  • 90.57 (n)
  • 91.98 (a)
Xkrx 16
Xkrx 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XKRX 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Xkrx 35
  • 90.48 (n)
  • 92.41 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 53 (a)
OneToMany
XKRX 35
  • 59.63 (n)
  • 53.26 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia xkrx 35
  • 58.33 (n)
  • 52.1 (a)
zebrafish
(Danio rerio)
Actinopterygii xkrx 35
  • 55.25 (n)
  • 47.64 (a)
xkrx 36
  • 42 (a)
OneToMany
Species with no ortholog for XKRX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XKRX Gene

ENSEMBL:
Gene Tree for XKRX (if available)
TreeFam:
Gene Tree for XKRX (if available)

Paralogs for XKRX Gene

Paralogs for XKRX Gene

Selected SIMAP similar genes for XKRX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with XKRX: view

Variants for XKRX Gene

Sequence variations from dbSNP and Humsavar for XKRX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs726516 -- 100,923,238(+) CTTTG(A/T)CCTCC intron-variant
rs916211 -- 100,926,314(-) CTTCC(C/G/T)CCTGT intron-variant
rs916212 -- 100,926,102(-) AAATG(A/G)AAACA intron-variant
rs1204414 -- 100,928,430(-) CTGTT(A/C)CCAAA utr-variant-5-prime
rs1204415 -- 100,927,738(-) TTTGG(C/G)CTGTG intron-variant

Relevant External Links for XKRX Gene

HapMap Linkage Disequilibrium report
XKRX
Locus Specific Mutation Databases (LSDB)
XKRX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for XKRX Gene

Disorders for XKRX Gene

No disorders were found for XKRX Gene.

No data available for UniProtKB/Swiss-Prot for XKRX Gene

Publications for XKRX Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  2. Identification of two new members, XPLAC and XTES, of the XK family. (PMID: 16431037) Calenda G. … Lee S. (Gene 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for XKRX Gene

Sources for XKRX Gene

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