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XKRX Gene

protein-coding   GIFtS: 41

GC0XM100055
XK, Kell blood group complex subunit-related, X-linked
(Previous names: X Kell blood group precursor-related, X-linked )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ60646 2
XKR2 1, 2, 3, 5
XPLAC 1, 2, 3, 5
XRG2 2, 3, 5
Descriptions
Membrane protein XPLAC 2, 3
X Kell blood group precursor-related, X-linked 1, 2
X Kell blood group-related, X-linked 3
XK, Kell blood group complex subunit-related, X-linked 2
External Ids
HGNC: 298451
Entrez Gene: 4024152
UniProtKB: Q6PP773
Ensembl: ENSG000001824897
Search outside databases for aliases for XKRX gene

Previous GC identifers: GC0XM098942 GC0XM099974

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for XKRX:
XKRX and XKR3 (MIM 611674) are homologs of the Kell blood group precursor XK (MIM 314850), which is
a putative membrane transporter and a component of the XK/Kell complex of the Kell blood group
system (Calenda et al., 2006 [PubMed 16431037]).[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XKRX gene  

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22

XKRX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM100055:     (about GC identifiers)

Start:
100,055,090 bp from pter
End:
100,070,554 bp from pter
Size:
15,465 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011651.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77 (See protein sequence)
Recommended Name: XK-related protein 2  
Size: 449 amino acids; 52052 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RNN6 B4DKU2 Q5H9J6
Alternative splicing: 2 isoforms:  Q6PP77-1   Q6PP77-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_997724.2  

    ENSEMBL proteins: 
    ENSP00000362047 ENSP00000327570 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
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    Antibodies for XKRX: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for XKRX

    Assays for XKRX: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6PP77

    UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77
    Similarity: Belongs to the XK family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XKRX)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_212559

                  Applied Biosystems Silencer® siRNAs for XKRX

                  Sigma-Aldrich siRNA for XKRX  
                         Sigma-Aldrich shRNA for XKRX  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_212559
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_212559
                                     untagged cDNA clone in CMV expression vector: NM_212559 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_212559

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for XKRX (ENSP000003275703) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KELENSP000003474093STRING (score=.89)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XKRX

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XKRX)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_212559

                  Sigma-Aldrich siRNA for XKRX  
                         Sigma-Aldrich shRNA for XKRX  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_212559  

    REFSEQ mRNAs for XKRX gene: 

    NM_212559.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_212559  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_212559
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_212559
                                     untagged cDNA clone in CMV expression vector: NM_212559 

    Additional cDNA sequence: 

    AK296711.1 AY534239.1 AY589511.1 BC137010.1 BC137011.1 

    1 DOTS entry:

    DT.210873 

    16 AceView cDNA sequences:

    AA257106 AY589511 NM_212559 AA856735 AI761820 BX116685 H87640 AI087330 
    BG675952 AA256009 BU682540 BF509819 AA648723 H87629 AA588027 H87641 

    highest scoring ESTs for XKRX:

    AA213814 AY589511 AA256009 AA257106 AA588027 AA648723 AA856735 AI761820 AW968072 AW974230 

    Unigene Cluster for XKRX:

    XK, Kell blood group complex subunit-related, X-linked
    Hs.592216  [show with all ESTs]
    Unigene Representative Sequence: AY589511


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000372956  ENST00000328526  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XKRX expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XKRX

    1 / 2 / 3

    3 probe-sets matching XKRX gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    53524_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA213814 0.80 1.00 0.91 1

    230349_at2, 3 U133-B 1 1.00 1.00 -- -- AA213814 0.80 1.00 0.91 1

    230349_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.592216

    UniProtKB/Swiss-Prot: XKR2_HUMAN, Q6PP77
    Tissue specificity: Expressed predominantly in the placenta, in syncythiotrophoblasts. Moderate
    levels in the adrenal gland, low levels in the trachea and very low levels in the bone marrow

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for XKRX gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    XKRX1   -- XK, Kell blood group complex subunit-related, X-linked 93.3(n)
    94.26(a)
    609590  XM_846877.1  XP_851970.1 
    chimpanzee
    (Pan troglodytes)
    XKRX1   -- XK, Kell blood group complex subunit-related, X-linked 99.93(n)
    100(a)
    473701  XM_529074.2  XP_529074.2 
    cow
    (Bos taurus)
    XKRX1   -- XK, Kell blood group complex subunit-related, X-linked 91.52(n)
    93.58(a)
    524975  XM_603316.2  XP_603316.2 
    rat
    (Rattus norvegicus)
    Xkrx1   -- XK, Kell blood group complex subunit-related, X-linked 90.48(n)
    92.41(a)
    497101  NM_001012230.1  NP_001012230.1 
    mouse
    (Mus musculus)
    Xkrx1, 5 X5
    X Kell blood group precursor related X linked1, 5 90.57(n)1
    91.98(a)1
    3315241  NM_183319.21  NP_899142.21 
     AK0416355  AK1720645  (see all 9)
    About this table        Species with no ortholog for XKRX

    ENSEMBL Gene Tree for XKRX
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for XKRX gene
    XK2  XKR32  XKRY22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/96 NCBI SNPs in XKRX are shown (see all 96 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 25)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs70584871,2
    F,H100055859(+) GATAGG/TCTTAA 1 -- ut314Minor allele frequency- T:0.02EU EA WA 418
    rs12044141,2
    H100070075(-) CTGTTC/ACCAAA 1 -- ut51 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs66528321,2
    H100056028(+) TCTGAG/ATTCTC 1 N/N syn1 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs12044151,2
    A,C,F,H,O100069383(-) TTTGGC/GCTGTG 1 -- int19Minor allele frequency- G:0.21EU EA WA NA 740
    rs9162121,2
    A,C,F,H,O100067747(-) AAATGA/GAAACA 1 -- int17Minor allele frequency- G:0.13EU EA WA NA 533
    rs12044181,2
    A,C,F,H,O100068258(-) ATTGCA/GAGAGA 1 -- int115Minor allele frequency- G:0.32EU EA WA NA 1130
    rs12044171,2
    A,C,F,H100068747(-) ccaccG/Acgcct 1 -- int18Minor allele frequency- A:0.29EU EA WA 628
    rs9162111,2
    A,C,F,H100067959(-) CTTCCC/GCCTGT 1 -- int1 trp34Minor allele frequency- G:0.18EU EA WA 418
    --
    rs110922871,2
    A,C100062925(+) tgatcC/Tgcctg 1 -- int10--------
    --
    rs59208741,2
    A,C100063624(+) CAGGCA/GCCTGC 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for XKRX (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300684

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    4 PubMed articles for XKRX gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 402415 HGNC: 29845 AceView: XKRX Ensembl:ENSG00000182489 euGenes: HUgn402415
    ECgene: XKRX H-InvDB: XKRX
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
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      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XKRX:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XKRX-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for XKRX Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for XKRX Browse small molecules at Sigma-Aldrich
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