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XKR9 Gene

protein-coding GIFtS: 35

GC08P071757

XK, Kell blood group complex subunit-related family, member 9
(Previous names: X Kell blood group precursor-related family, member 9 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
XRG9 ^², ³

Descriptions
X Kell blood group precursor-related family, member 9 ^¹, ²
XK, Kell blood group complex subunit-related family, member 9 ^²
XK-related protein 9 ^²

External Ids
HGNC: 20937¹
Entrez Gene: 389668²
UniProtKB: Q5GH70³
Ensembl: ENSG00000198669⁷

Search outside databases for aliases for XKR9 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XKR9 gene

Entrez Gene cytogenetic band: 8q13.3 Ensembl cytogenetic band: 8q13.3 HGNC cytogenetic band: 8q13.3

XKR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P071757: (about GC identifiers)

Start:	71,744,154 bp from pter
End:	71,810,731 bp from pter
Size:	66,578 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XKR9_HUMAN, Q5GH70 (See protein sequence)

Recommended Name: XK-related protein 9

Size: 373 amino acids; 43406 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: B2RNS9

REFSEQ proteins: NP_001011720.1
Human Recombinant Proteins

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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for XKR9:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for XKR9

Assays for XKR9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q5GH70

ProtoNet protein and cluster: Q5GH70

UniProtKB/Swiss-Prot: XKR9_HUMAN, Q5GH70

Similarity: Belongs to the XK family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR9)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001011720

Applied Biosystems Silencer® siRNAs for XKR9

Sigma-Aldrich siRNA for XKR9

Sigma-Aldrich shRNA for XKR9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XKR9
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001011720
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001011720
untagged cDNA clone in CMV expression vector: NM_001011720

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001011720

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XKR9

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR9)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001011720

Sigma-Aldrich siRNA for XKR9

Sigma-Aldrich shRNA for XKR9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001011720

REFSEQ mRNAs for XKR9 gene:

NM_001011720.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001011720

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001011720
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001011720
                                 untagged cDNA clone in CMV expression vector: NM_001011720

Additional cDNA sequence:

AY534247.1 BC111381.1 BC137104.1 BC137105.1 BC151845.1

2 DOTS entries:

DT.95265708 DT.95149673

13 AceView cDNA sequences:

AW081706 AA897450 BU674903 BI752949 AW847396 CD359427 AW847339 AW847342

AW847385 BU932538 AW847408 BX509391 BU853591

highest scoring ESTs for XKR9:

AA897450 AW081706 AW801718 AW801787 AW847339 AW847342 AW847346 AW847385 AW847395 AW847396

Unigene Cluster for XKR9:

XK, Kell blood group complex subunit-related family, member 9

Hs.458938 [show with all ESTs]

Unigene Representative Sequence: AY534247

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000354493

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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XKR9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XKR9

¹ Data from GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.458938

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for XKR9 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XKR9¹	--	XK, Kell blood group complex subunit-related family, more	88.71(n) 82.8(a)	610280 XM_847742.1 XP_852835.1
chimpanzee (Pan troglodytes)	XKR9¹	--	XK, Kell blood group complex subunit-related family, more	99.64(n) 99.73(a)	613219 NM_001033038.1 NP_001028210.1
rat (Rattus norvegicus)	Xkr9¹	--	XK, Kell blood group complex subunit-related family, more	79.27(n) 75.87(a)	497099 NM_001012229.1 NP_001012229.1
mouse (Mus musculus)	Xkr9^{1, 5}	1⁵	X Kell blood group precursor related family member more^{1, 5}	80.88(n)¹ 76.68(a)¹	381246¹ NM_001011873.2¹ NP_001011873.1¹ AY534255⁵ BC147699⁵ (see all 6)
chicken (Gallus gallus)	XKR9¹	--	XK, Kell blood group complex subunit-related family, more	59.5(n) 45.16(a)	428363 NM_001034824.1 NP_001029996.1

About this table Species with no ortholog for XKR9

ENSEMBL Gene Tree for XKR9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/411 NCBI SNPs in XKR9 are shown (see all 411 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2218430^1,2	A,C,F,H	71810159(-)	`tttcaA/Cacaca`	1	--	ut3¹ ese³		4		EU EA WA	418
	rs2290702^1,2	C,F,H,O	71809534(-)	`ACAGTA/GGTATT`	1	--	ut3¹ ese³		9		EA NA EU WA	2082
	rs12681420^1,2	C,F,H	71755752(+)	`ATTCAA/GTGCTA`	1	--	ut5¹ ese³		4		EU EA WA	418
--	rs7387471^1,2	A,C	71810468(+)	`tcattA/Gttcag`	1	--	ut3¹		0	--	--	--	--
	rs420370^1,2	H	71809564(-)	`CTCTTC/TCCTTT`	1	--	ut3¹ ese³ trp³		4		EU EA WA	412
	rs453136^1,2	H	71809168(-)	`ACTGGT/GTTTCC`	1	N/K	mis¹		5		MN EU EA WA	596
	rs8180973^1,2	H	71809805(+)	`ATTAAT/CGCACT`	1	--	ut3¹ ese³		4		EU EA WA	408
	rs6991329^1,2	A,C,F,H	71755979(+)	`TTAGCG/ATTAAG`	1	A/A	syn¹		4		EU EA WA	418
	rs2290703^1,2	F,H	71809030(-)	`GGATTA/GAAAAT`	1	F/F	syn¹ ese³		5		EA EU WA	1894
	rs268651^1,2	A,C,F,H,O	71779536(-)	`GAAGTG/TGTTTA`	1	--	int¹		12		EU EA WA NA	1054

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HapMap Linkage Disequilibrium images for XKR9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for XKR9 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 389668	HGNC: 20937	AceView: LOC389668	Ensembl:ENSG00000198669	euGenes: HUgn389668
ECgene: XKR9	H-InvDB: XKR9

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for XKR9
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XKR9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XKR9-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XKR9		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XKR9		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for XKR9

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XKR9 Gene

protein-coding GIFtS: 35

Aliases &
Descriptions
for XKR9

Summaries
for XKR9

Genomic Location
for XKR9

Proteins
for XKR9

Protein Domains/
Families
for XKR9

Gene Function
for XKR9

Pathways & Interactions
for XKR9

Drugs & Compounds
for XKR9

Transcripts
for XKR9

Expression
for XKR9

Orthologs
for XKR9

Paralogs
for XKR9

SNPs/Variants
for XKR9

Disorders & Mutations
for XKR9

Medical News
for XKR9

Publications
for XKR9

Search for XKR9

Genome Databases showing XKR9

Other Databases showing XKR9

Specialized Databases showing XKR9

Licensable Technologies
for XKR9

Services
for XKR9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XKR9 Gene

protein-coding GIFtS: 35

Aliases & Descriptionsfor XKR9

Summariesfor XKR9

Genomic Locationfor XKR9

Proteinsfor XKR9

Protein Domains/Familiesfor XKR9

Gene Functionfor XKR9

Pathways & Interactionsfor XKR9

Drugs & Compoundsfor XKR9

Transcriptsfor XKR9

Expression for XKR9

Orthologsfor XKR9

Paralogsfor XKR9

SNPs/Variantsfor XKR9

Disorders & Mutationsfor XKR9

Medical Newsfor XKR9

Publicationsfor XKR9

Search for XKR9

Genome Databases showing XKR9

Other Databases showing XKR9

Specialized Databases showing XKR9

Licensable Technologiesfor XKR9

Servicesfor XKR9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XKR9

Summaries
for XKR9

Genomic Location
for XKR9

Proteins
for XKR9

Protein Domains/
Families
for XKR9

Gene Function
for XKR9

Pathways & Interactions
for XKR9

Drugs & Compounds
for XKR9

Transcripts
for XKR9

Expression
for XKR9

Orthologs
for XKR9

Paralogs
for XKR9

SNPs/Variants
for XKR9

Disorders & Mutations
for XKR9

Medical News
for XKR9

Publications
for XKR9

Licensable Technologies
for XKR9

Services
for XKR9