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Aliases for XKR9 Gene

Aliases for XKR9 Gene

  • XK Related 9 2 3 5
  • XK, Kell Blood Group Complex Subunit-Related Family, Member 9 2 3
  • X Kell Blood Group Precursor-Related Family, Member 9 2 3
  • XRG9 3 4
  • X-Linked Kx Blood Group Related 9 3
  • XK-Related Protein 9 3

External Ids for XKR9 Gene

Previous GeneCards Identifiers for XKR9 Gene

  • GC08P071757
  • GC08P071581
  • GC08P067074

Summaries for XKR9 Gene

GeneCards Summary for XKR9 Gene

XKR9 (XK Related 9) is a Protein Coding gene. An important paralog of this gene is XKR8.

Additional gene information for XKR9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR9 Gene

Genomics for XKR9 Gene

Regulatory Elements for XKR9 Gene

Enhancers for XKR9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H070665 1.4 Ensembl ENCODE 71.5 -1.3 -1329 5 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 XKR9 LACTB2-AS1 TRAM1 LACTB2 RN7SL19P
GH08H070606 1.7 FANTOM5 Ensembl ENCODE 41.1 -60.6 -60598 5 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF207 XKR9 LACTB2 TRAM1 LACTB2-AS1 RN7SL19P
GH08H070770 0.9 ENCODE 71.8 +101.9 101862 1 ELF3 FOXA2 MLX ARID4B DMAP1 RAD21 THRB RARA YY1 CREM XKR9 ENSG00000223220
GH08H070804 0.8 Ensembl ENCODE 71.8 +136.2 136177 1 SOX13 POLR2A POU5F1 CTBP2 XKR9 LACTB2 PIR51932 GC08P070822 ENSG00000223220
GH08H071044 0.6 ENCODE 65.8 +377.0 376958 2 JUND ATF3 USF2 MAX FOS MYC XKR9 LOC105375894 GC08M070811
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XKR9 on UCSC Golden Path with GeneCards custom track

Promoters for XKR9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000225757 -363 1600 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207

Genomic Location for XKR9 Gene

Chromosome:
8
Start:
70,669,363 bp from pter
End:
71,065,788 bp from pter
Size:
396,426 bases
Orientation:
Plus strand

Genomic View for XKR9 Gene

Genes around XKR9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKR9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKR9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR9 Gene

Proteins for XKR9 Gene

  • Protein details for XKR9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GH70-XKR9_HUMAN
    Recommended name:
    XK-related protein 9
    Protein Accession:
    Q5GH70
    Secondary Accessions:
    • B2RNS9
    • B9EH74

    Protein attributes for XKR9 Gene

    Size:
    373 amino acids
    Molecular mass:
    43406 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XKR9 Gene

Post-translational modifications for XKR9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for XKR9 Gene

Domains & Families for XKR9 Gene

Gene Families for XKR9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for XKR9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XKR9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GH70

UniProtKB/Swiss-Prot:

XKR9_HUMAN :
  • Belongs to the XK family.
Family:
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR9: view

Function for XKR9 Gene

Phenotypes From GWAS Catalog for XKR9 Gene

Phenotypes for XKR9 Gene

genes like me logo Genes that share phenotypes with XKR9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for XKR9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XKR9 Gene

Localization for XKR9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XKR9 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for XKR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR9: view

Pathways & Interactions for XKR9 Gene

No Data Available

Interacting Proteins for XKR9 Gene

Gene Ontology (GO) - Biological Process for XKR9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for XKR9 Gene

Drugs & Compounds for XKR9 Gene

No Compound Related Data Available

Transcripts for XKR9 Gene

Unigene Clusters for XKR9 Gene

XK, Kell blood group complex subunit-related family, member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for XKR9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for XKR9 Gene

No ASD Table

Relevant External Links for XKR9 Gene

GeneLoc Exon Structure for
XKR9
ECgene alternative splicing isoforms for
XKR9

Expression for XKR9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XKR9 Gene

mRNA differential expression in normal tissues according to GTEx for XKR9 Gene

This gene is overexpressed in Testis (x9.2) and Liver (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of XKR9 Gene:

XKR9

SOURCE GeneReport for Unigene cluster for XKR9 Gene:

Hs.458938
genes like me logo Genes that share expression patterns with XKR9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XKR9 Gene

Orthologs for XKR9 Gene

This gene was present in the common ancestor of animals.

Orthologs for XKR9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XKR9 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia XKR9 33 34
  • 88.71 (n)
cow
(Bos Taurus)
Mammalia XKR9 33 34
  • 86.92 (n)
mouse
(Mus musculus)
Mammalia Xkr9 33 16 34
  • 80.88 (n)
rat
(Rattus norvegicus)
Mammalia Xkr9 33
  • 79.27 (n)
oppossum
(Monodelphis domestica)
Mammalia XKR9 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XKR9 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves XKR9 33 34
  • 58.83 (n)
lizard
(Anolis carolinensis)
Reptilia XKR9 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xkr9 33
  • 56.83 (n)
zebrafish
(Danio rerio)
Actinopterygii xkr9 33 34
  • 50.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32579 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-8 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
OneToMany
Species where no ortholog for XKR9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XKR9 Gene

ENSEMBL:
Gene Tree for XKR9 (if available)
TreeFam:
Gene Tree for XKR9 (if available)

Paralogs for XKR9 Gene

Paralogs for XKR9 Gene

(5) SIMAP similar genes for XKR9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with XKR9: view

Variants for XKR9 Gene

Sequence variations from dbSNP and Humsavar for XKR9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000007744 -- 70,867,772(+) TAACT(C/G/T)ATTTC intron-variant
rs1000012063 -- 70,801,501(+) TTTCT(A/G)TTTTC intron-variant
rs1000015678 -- 70,853,926(+) CTATC(A/G)TTGTT intron-variant
rs1000029149 -- 70,818,635(+) TGCTT(A/G)GTATA intron-variant
rs1000029795 -- 70,759,638(+) TGACT(A/G)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XKR9 Gene

Variant ID Type Subtype PubMed ID
esv1992859 CNV deletion 18987734
esv2493520 CNV deletion 19546169
esv2662380 CNV deletion 23128226
esv2669629 CNV deletion 23128226
esv2737144 CNV deletion 23290073
esv2737145 CNV deletion 23290073
esv2761435 CNV loss 21179565
esv3271940 CNV deletion 24192839
esv3543629 CNV deletion 23714750
esv3543631 CNV deletion 23714750
esv3572810 CNV loss 25503493
esv3576585 CNV gain 25503493
esv3617571 CNV loss 21293372
esv994889 CNV deletion 20482838
nsv1068714 OTHER inversion 25765185
nsv1124350 CNV deletion 24896259
nsv1152729 CNV deletion 26484159
nsv512052 CNV loss 21212237
nsv520505 CNV loss 19592680
nsv6249 CNV deletion 18451855
nsv956065 CNV deletion 24416366
nsv957646 CNV deletion 24416366

Variation tolerance for XKR9 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XKR9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XKR9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR9 Gene

Disorders for XKR9 Gene

Relevant External Links for XKR9

Genetic Association Database (GAD)
XKR9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XKR9

No disorders were found for XKR9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XKR9 Gene

Publications for XKR9 Gene

  1. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K … Rivadeneira F (Nature genetics 2012) 3 60
  2. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 45 60
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for XKR9 Gene

Sources for XKR9 Gene

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