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Aliases for XKR8 Gene

Aliases for XKR8 Gene

  • XK, Kell Blood Group Complex Subunit-Related Family, Member 8 2 3
  • X Kell Blood Group Precursor-Related Family, Member 8 2 3
  • HXkr8 3 4
  • XRG8 3 4
  • XK-Related Protein 8 3

External Ids for XKR8 Gene

Previous GeneCards Identifiers for XKR8 Gene

  • GC01P028158
  • GC01P028285
  • GC01P026541

Summaries for XKR8 Gene

GeneCards Summary for XKR8 Gene

XKR8 (XK, Kell Blood Group Complex Subunit-Related Family, Member 8) is a Protein Coding gene. An important paralog of this gene is XKR9.

UniProtKB/Swiss-Prot for XKR8 Gene

  • Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR8 Gene

Genomics for XKR8 Gene

Regulatory Elements for XKR8 Gene

Genomic Location for XKR8 Gene

Start:
27,959,462 bp from pter
End:
27,968,096 bp from pter
Size:
8,635 bases
Orientation:
Plus strand

Genomic View for XKR8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XKR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR8 Gene

Proteins for XKR8 Gene

  • Protein details for XKR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6D3-XKR8_HUMAN
    Recommended name:
    XK-related protein 8
    Protein Accession:
    Q9H6D3
    Secondary Accessions:

    Protein attributes for XKR8 Gene

    Size:
    395 amino acids
    Molecular mass:
    44655 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Expression is repressed in PLB-985 leukemia and Raji lymphoma cells due to CpG methylation near the transcription start site of XKR8 gene, possibly explaining the inability of PLB-985 leukemia and Raji lymphoma cells to expose phosphatidylserine during apoptosis.

neXtProt entry for XKR8 Gene

Proteomics data for XKR8 Gene at MOPED

Post-translational modifications for XKR8 Gene

  • Undergoes proteolytic processing by caspase-3 (CASP3), leading to its activation.

Other Protein References for XKR8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKR8 Gene

Domains for XKR8 Gene

Protein Domains for XKR8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XKR8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6D3

UniProtKB/Swiss-Prot:

XKR8_HUMAN :
  • Q9H6D3
Family:
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR8: view

No data available for Gene Families for XKR8 Gene

Function for XKR8 Gene

Molecular function for XKR8 Gene

UniProtKB/Swiss-Prot Function: Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.

Phenotypes for XKR8 Gene

MGI mutant phenotypes for XKR8:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with XKR8: view

Animal Models for XKR8 Gene

MGI Knock Outs for XKR8:

Animal Model Products

CRISPR Products

miRNA for XKR8 Gene

miRTarBase miRNAs that target XKR8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for XKR8 Gene

Localization for XKR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XKR8 Gene COMPARTMENTS Subcellular localization image for XKR8 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for XKR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23845944
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR8: view

Pathways for XKR8 Gene

SuperPathways for XKR8 Gene

No Data Available

Interacting Proteins for XKR8 Gene

Gene Ontology (GO) - Biological Process for XKR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043652 engulfment of apoptotic cell IDA 23845944
GO:0070782 phosphatidylserine exposure on apoptotic cell surface IDA 23845944
genes like me logo Genes that share ontologies with XKR8: view

No data available for Pathways by source for XKR8 Gene

Transcripts for XKR8 Gene

mRNA/cDNA for XKR8 Gene

Unigene Clusters for XKR8 Gene

XK, Kell blood group complex subunit-related family, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XKR8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKR8 Gene

No ASD Table

Relevant External Links for XKR8 Gene

GeneLoc Exon Structure for
XKR8
ECgene alternative splicing isoforms for
XKR8

Expression for XKR8 Gene

mRNA expression in normal human tissues for XKR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XKR8 Gene

This gene is overexpressed in Whole Blood (9.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for XKR8 Gene

SOURCE GeneReport for Unigene cluster for XKR8 Gene Hs.55024

genes like me logo Genes that share expressions with XKR8: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for XKR8 Gene

Orthologs for XKR8 Gene

This gene was present in the common ancestor of animals.

Orthologs for XKR8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XKR8 35
  • 99.32 (n)
  • 98.99 (a)
XKR8 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XKR8 35
  • 84.48 (n)
  • 78.63 (a)
XKR8 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMPDL3B 36
  • 81 (a)
OneToOne
XKR8 35
  • 87.28 (n)
  • 82.7 (a)
mouse
(Mus musculus)
Mammalia Xkr8 35
  • 77.15 (n)
  • 70.1 (a)
Xkr8 16
Xkr8 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XKR8 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xkr8 35
  • 76.63 (n)
  • 69.33 (a)
chicken
(Gallus gallus)
Aves XKR8 35
  • 61.52 (n)
  • 51.52 (a)
XKR8 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XKR8 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xkr8 35
  • 49.95 (n)
  • 42.82 (a)
zebrafish
(Danio rerio)
Actinopterygii XKR8 (4 of 4) 36
  • 29 (a)
OneToMany
xkr8.1 36
  • 30 (a)
OneToMany
xkr8.2 36
  • 31 (a)
OneToMany
xkr8.3 35
  • 52.65 (n)
  • 42.05 (a)
xkr8.3 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32579 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-8 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
Species with no ortholog for XKR8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XKR8 Gene

ENSEMBL:
Gene Tree for XKR8 (if available)
TreeFam:
Gene Tree for XKR8 (if available)

Paralogs for XKR8 Gene

Paralogs for XKR8 Gene

Selected SIMAP similar genes for XKR8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for XKR8 Gene

genes like me logo Genes that share paralogs with XKR8: view

Variants for XKR8 Gene

Sequence variations from dbSNP and Humsavar for XKR8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1129832 -- 27,967,449(+) AATTA(C/T)GTACA utr-variant-3-prime
rs1129835 -- 27,967,564(+) ATAGG(G/T)GCTGC utr-variant-3-prime
rs1129837 -- 27,967,568(+) GTGCT(G/T)CCCCA utr-variant-3-prime
rs1129841 -- 27,967,613(+) CAGGG(A/G)CTGTC utr-variant-3-prime
rs1129842 -- 27,967,635(+) TTCCT(C/T)CCCTC utr-variant-3-prime

Relevant External Links for XKR8 Gene

HapMap Linkage Disequilibrium report
XKR8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for XKR8 Gene

Disorders for XKR8 Gene

No disorders were found for XKR8 Gene.

No data available for UniProtKB/Swiss-Prot for XKR8 Gene

Publications for XKR8 Gene

  1. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. (PMID: 23845944) Suzuki J. … Nagata S. (Science 2013) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3

Products for XKR8 Gene

Sources for XKR8 Gene

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