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Aliases for XKR8 Gene

Aliases for XKR8 Gene

  • XK Related 8 2 3 5
  • XK, Kell Blood Group Complex Subunit-Related Family, Member 8 2 3
  • X Kell Blood Group Precursor-Related Family, Member 8 2 3
  • HXkr8 3 4
  • XRG8 3 4
  • X-Linked Kx Blood Group Related 8 3
  • XK-Related Protein 8 3

External Ids for XKR8 Gene

Previous GeneCards Identifiers for XKR8 Gene

  • GC01P028158
  • GC01P028285
  • GC01P026541

Summaries for XKR8 Gene

GeneCards Summary for XKR8 Gene

XKR8 (XK Related 8) is a Protein Coding gene. An important paralog of this gene is XKR7.

UniProtKB/Swiss-Prot for XKR8 Gene

  • Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR8 Gene

Genomics for XKR8 Gene

Regulatory Elements for XKR8 Gene

Enhancers for XKR8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G027866 1.9 FANTOM5 Ensembl ENCODE dbSUPER 31.1 -90.8 -90823 3.3 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ZNF766 FOS KLF13 SP3 XKR8 ACTG1P20 THEMIS2 GMEB1 PHACTR4 SNHG12 RPA2 ENSG00000231344 NPM1P39 TRNAU1AP
GH01G027881 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.6 -71.7 -71652 11.7 HDGF PKNOX1 ARNT ZNF121 ZNF143 JUNB REST TBX21 ZNF592 SREBF1 RPA2 XKR8 THEMIS2 SMPDL3B ENSG00000227050 EYA3 SCARNA1 PPP1R8 RNU6-1245P FGR
GH01G028313 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.8 +355.0 355043 2.6 HDGF PKNOX1 FOXA2 SIN3A ARID4B YY1 ZNF121 FOS DEK SMARCB1 XKR8 THEMIS2 PHACTR4 PTAFR MED18 SESN2 GMEB1 TAF12 EYA3
GH01G027871 1.7 FANTOM5 ENCODE dbSUPER 21.9 -84.8 -84839 5.3 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 SIN3A FEZF1 GTF3C2 ZNF143 ZNF207 FGR THEMIS2 RPA2 XKR8 EYA3 GMEB1 PHACTR4 PTAFR SNHG12 ACTG1P20
GH01G028152 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.2 +194.6 194615 2.3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF48 ZNF766 GATA2 KLF7 PTAFR XKR8 THEMIS2 EYA3 DNAJC8 ATPIF1 SESN2 MED18 STX12 PIR61473
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XKR8 on UCSC Golden Path with GeneCards custom track

Promoters for XKR8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003796 438 1401 ZNF133 SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 ZNF143 KLF7 FOS

Genomic Location for XKR8 Gene

Chromosome:
1
Start:
27,959,462 bp from pter
End:
27,968,096 bp from pter
Size:
8,635 bases
Orientation:
Plus strand

Genomic View for XKR8 Gene

Genes around XKR8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR8 Gene

Proteins for XKR8 Gene

  • Protein details for XKR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6D3-XKR8_HUMAN
    Recommended name:
    XK-related protein 8
    Protein Accession:
    Q9H6D3

    Protein attributes for XKR8 Gene

    Size:
    395 amino acids
    Molecular mass:
    44655 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Expression is repressed in PLB-985 leukemia and Raji lymphoma cells due to CpG methylation near the transcription start site of XKR8 gene, possibly explaining the inability of PLB-985 leukemia and Raji lymphoma cells to expose phosphatidylserine during apoptosis.

neXtProt entry for XKR8 Gene

Post-translational modifications for XKR8 Gene

  • Undergoes proteolytic processing by caspase-3 (CASP3), leading to its activation.

Other Protein References for XKR8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKR8 Gene

Domains & Families for XKR8 Gene

Gene Families for XKR8 Gene

Protein Domains for XKR8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XKR8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6D3

UniProtKB/Swiss-Prot:

XKR8_HUMAN :
  • Belongs to the XK family.
Family:
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR8: view

Function for XKR8 Gene

Molecular function for XKR8 Gene

UniProtKB/Swiss-Prot Function:
Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.

Phenotypes for XKR8 Gene

MGI mutant phenotypes for XKR8:
inferred from 2 alleles
GenomeRNAi human phenotypes for XKR8:
genes like me logo Genes that share phenotypes with XKR8: view

Animal Models for XKR8 Gene

MGI Knock Outs for XKR8:

Animal Model Products

  • Taconic Biosciences Mouse Models for XKR8

CRISPR Products

miRNA for XKR8 Gene

miRTarBase miRNAs that target XKR8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XKR8 Gene

Localization for XKR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XKR8 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for XKR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23845944
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR8: view

Pathways & Interactions for XKR8 Gene

No Data Available

Interacting Proteins for XKR8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362991%0d%0a9606.ENSP00000263388%0d%0a
Selected Interacting proteins: Q9H6D3-XKR8_HUMAN ENSP00000362991 for XKR8 Gene via IID STRING

Gene Ontology (GO) - Biological Process for XKR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043652 engulfment of apoptotic cell IDA 23845944
GO:0070782 phosphatidylserine exposure on apoptotic cell surface IDA 23845944
genes like me logo Genes that share ontologies with XKR8: view

No data available for Pathways by source and SIGNOR curated interactions for XKR8 Gene

Transcripts for XKR8 Gene

Unigene Clusters for XKR8 Gene

XK, Kell blood group complex subunit-related family, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKR8 Gene

No ASD Table

Relevant External Links for XKR8 Gene

GeneLoc Exon Structure for
XKR8
ECgene alternative splicing isoforms for
XKR8

Expression for XKR8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XKR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XKR8 Gene

This gene is overexpressed in Whole Blood (x9.8).

Protein differential expression in normal tissues from HIPED for XKR8 Gene

This gene is overexpressed in Heart (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for XKR8 Gene



Protein tissue co-expression partners for XKR8 Gene

NURSA nuclear receptor signaling pathways regulating expression of XKR8 Gene:

XKR8

SOURCE GeneReport for Unigene cluster for XKR8 Gene:

Hs.55024

Evidence on tissue expression from TISSUES for XKR8 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with XKR8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XKR8 Gene

Orthologs for XKR8 Gene

This gene was present in the common ancestor of animals.

Orthologs for XKR8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XKR8 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia XKR8 34
  • 87.28 (n)
SMPDL3B 35
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XKR8 34 35
  • 84.48 (n)
mouse
(Mus musculus)
Mammalia Xkr8 34 16 35
  • 77.15 (n)
rat
(Rattus norvegicus)
Mammalia Xkr8 34
  • 76.63 (n)
oppossum
(Monodelphis domestica)
Mammalia XKR8 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves XKR8 34 35
  • 61.52 (n)
lizard
(Anolis carolinensis)
Reptilia XKR8 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xkr8 34
  • 49.95 (n)
zebrafish
(Danio rerio)
Actinopterygii xkr8.3 34 35
  • 52.65 (n)
xkr8.2 35
  • 31 (a)
OneToMany
xkr8.1 35
  • 30 (a)
OneToMany
XKR8 (4 of 4) 35
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32579 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-8 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 14 (a)
OneToMany
Species where no ortholog for XKR8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XKR8 Gene

ENSEMBL:
Gene Tree for XKR8 (if available)
TreeFam:
Gene Tree for XKR8 (if available)

Paralogs for XKR8 Gene

Paralogs for XKR8 Gene

(1) SIMAP similar genes for XKR8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for XKR8 Gene

genes like me logo Genes that share paralogs with XKR8: view

Variants for XKR8 Gene

Sequence variations from dbSNP and Humsavar for XKR8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000692778 -- 27,961,927(+) ACCCC(A/G)GACCT intron-variant
rs1000746227 -- 27,961,554(+) TGAGC(C/T)GTGAA intron-variant
rs1001531251 -- 27,958,854(+) TCACC(C/T)TCTTC upstream-variant-2KB, utr-variant-3-prime
rs1001629287 -- 27,957,652(+) TGAGG(A/G)GTTTA intron-variant, upstream-variant-2KB
rs1001749762 -- 27,963,147(+) GCCTC(C/G)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XKR8 Gene

Variant ID Type Subtype PubMed ID
esv3585567 CNV loss 21293372
nsv945852 CNV duplication 23825009

Variation tolerance for XKR8 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XKR8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XKR8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR8 Gene

Disorders for XKR8 Gene

Relevant External Links for XKR8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XKR8

No disorders were found for XKR8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XKR8 Gene

Publications for XKR8 Gene

  1. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. (PMID: 23845944) Suzuki J. … Nagata S. (Science 2013) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane. (PMID: 26936867) Bevers E.M. … Williamson P.L. (Physiol. Rev. 2016) 3 64

Products for XKR8 Gene

Sources for XKR8 Gene

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