V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

XKR8 Gene

protein-coding GIFtS: 38

GC01P028158

XK, Kell blood group complex subunit-related family, member 8
(Previous names: X Kell blood group precursor-related family, member 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ10307 ^¹, ²
OTTHUMP00000004007 ^²
RP11-460I13.3 ^²
XRG8 ^², ³

Descriptions
X Kell blood group precursor-related family, member 8 ^¹, ²
XK, Kell blood group complex subunit-related family, member 8 ^²

External Ids
HGNC: 25508¹
Entrez Gene: 55113²
UniProtKB: Q9H6D3³
Ensembl: ENSG00000158156⁷

Search outside databases for aliases for XKR8 gene

Previous GC identifer: GC01P027971

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XKR8 gene

Entrez Gene cytogenetic band: 1p35.3 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35.3

XKR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P028158: (about GC identifiers)

Start:	28,159,091 bp from pter
End:	28,167,191 bp from pter
Size:	8,101 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004610.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XKR8_HUMAN, Q9H6D3 (See protein sequence)

Recommended Name: XK-related protein 8

Size: 395 amino acids; 44655 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

REFSEQ proteins: NP_060523.2

ENSEMBL proteins:

ENSP00000362991

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for XKR8:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for XKR8

Assays for XKR8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H6D3

ProtoNet protein and cluster: Q9H6D3

UniProtKB/Swiss-Prot: XKR8_HUMAN, Q9H6D3

Similarity: Belongs to the XK family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR8)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018053

Applied Biosystems Silencer® siRNAs for XKR8

Sigma-Aldrich siRNA for XKR8

Sigma-Aldrich shRNA for XKR8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XKR8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018053
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018053
untagged cDNA clones in CMV expression vector (see all 2): NM_018053

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018053

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XKR8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR8)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018053

Sigma-Aldrich siRNA for XKR8

Sigma-Aldrich shRNA for XKR8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018053

REFSEQ mRNAs for XKR8 gene:

NM_018053.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018053

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018053
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018053
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018053

Additional cDNA sequence:

AK001169.1 AK026024.1 AK054909.1 AK091615.1 AY534246.1 BC003606.1 BC013379.2 BC028564.2

2 DOTS entries:

DT.87004813 DT.95317279

24/68 AceView cDNA sequences (see all 68 ):

AA337901 AA429355 BM053086 AI928336 AI872884 AA290680 NM_018053 AV646192

AW139953 AI811265 CN480397 CK903991 AA908237 BC013379 AU123420 AI360321

BC003606 AA284533 BC028564 AK026024 BQ670357 AA287219 BV203337 BE408087

highest scoring ESTs for XKR8:

AA747448 AA071079 AA071163 AA284533 AA287219 AA290680 AA337901 AA429355 AA455138 AA464322

Unigene Cluster for XKR8:

XK, Kell blood group complex subunit-related family, member 8

Hs.55024 [show with all ESTs]

Unigene Representative Sequence: AK054909

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000373884

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XKR8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XKR8

¹ / ² / ³

4 probe-sets matching XKR8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
71270_at²^{, 3}	U95-D	1	1.00	1.00	0.92	0.59	AI928336	0.80	1.00	0.91	1
53100_at²^{, 3}	U95-B	2	1.00	0.50	0.28	1.42	AA747448	1.00	0.87	0.94	1
218753_at²^{, 3}	U133-A	2	1.00	0.64	--	--	NM_018053	0.60	1.00	0.82	1
218753_at²	U133Plus2	2	1.00	0.64	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.55024

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XKR8 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XKR8¹	--	XK, Kell blood group complex subunit-related family, more	87.28(n) 82.7(a)	487337 XM_544463.1 XP_544463.1
chimpanzee (Pan troglodytes)	XKR8¹	--	XK, Kell blood group complex subunit-related family, more	99.32(n) 98.99(a)	613218 NM_001033037.1 NP_001028209.1
cow (Bos taurus)	XKR8¹	--	XK, Kell blood group complex subunit-related family, more	84.48(n) 78.63(a)	514365 XM_592202.3 XP_592202.2
rat (Rattus norvegicus)	Xkr8¹	--	XK, Kell blood group complex subunit-related family, more	76.55(n) 69.33(a)	313033 NM_001012099.1 NP_001012099.1
mouse (Mus musculus)	Xkr8^{1, 5}	4⁵	X Kell blood group precursor related family member more^{1, 5}	77.09(n)¹ 70.28(a)¹	381560¹ NM_201368.1¹ NP_958756.1¹ AI597014⁵ AK029920⁵ (see all 9)

About this table Species with no ortholog for XKR8

ENSEMBL Gene Tree for XKR8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XKR8 gene

ENSG00000221947²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/47 NCBI SNPs in XKR8 are shown (see all 47 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 29)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4466676^1,2	A,C,F,H	28167297(-)	`CTGTTC/TGTGGA`	1	--	ng3¹		12		EA NA EU WA	982
--	rs6673064^1,2	A,F,H	28166299(+)	`GATAGA/GTGAAC`	1	--	ut3¹		4		EU EA WA	420
--	rs6667774^1,2	A,C	28166920(+)	`AACTCC/TGGGTG`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs1129832^1,2	F	28166547(+)	`AATTAT/CGTACA`	1	--	ut3¹		1		MN	184
--	rs17838116^1,2	F	28166666(+)	`GTGCTG/TCCCCA`	1	--	ut3¹ ese³		1		MN	184
--	rs4243821^1,2	C	28166638(-)	`GAGGTA/GGCCAG`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs4373781^1,2	A,C,F,H	28162818(-)	`GACAGC/GGGGGC`	1	--	int¹		3		EA WA	298
	rs4357550^1,2	A,C,F,H	28164363(-)	`CACTCG/ACAGTG`	1	--	int¹		4		EU EA WA	418
--	rs4243820^1,2	A,C,F,H	28165326(-)	`GTGACC/TTGTGG`	1	--	int¹		3		EA WA	296
--	rs4908384^1,2	A	28163333(+)	`gctcaA/Ggtaac`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for XKR8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for XKR8 gene:

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55113	HGNC: 25508	AceView: FLJ10307	Ensembl:ENSG00000158156	euGenes: HUgn55113
ECgene: XKR8	H-InvDB: XKR8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for XKR8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XKR8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XKR8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XKR8		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XKR8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for XKR8

Search Tocris compounds for XKR8

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for XKR8

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
XKR8 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

XKR8 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for XKR8

Summaries
for XKR8

Genomic Location
for XKR8

Proteins
for XKR8

Protein Domains/
Families
for XKR8

Gene Function
for XKR8

Pathways & Interactions
for XKR8

Drugs & Compounds
for XKR8

Transcripts
for XKR8

Expression
for XKR8

Orthologs
for XKR8

Paralogs
for XKR8

SNPs/Variants
for XKR8

Disorders & Mutations
for XKR8

Medical News
for XKR8

Publications
for XKR8

Search for XKR8

Genome Databases showing XKR8

Other Databases showing XKR8

Specialized Databases showing XKR8

Licensable Technologies
for XKR8

Services
for XKR8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XKR8 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor XKR8

Summariesfor XKR8

Genomic Locationfor XKR8

Proteinsfor XKR8

Protein Domains/Familiesfor XKR8

Gene Functionfor XKR8

Pathways & Interactionsfor XKR8

Drugs & Compoundsfor XKR8

Transcriptsfor XKR8

Expression for XKR8

Orthologsfor XKR8

Paralogsfor XKR8

SNPs/Variantsfor XKR8

Disorders & Mutationsfor XKR8

Medical Newsfor XKR8

Publicationsfor XKR8

Search for XKR8

Genome Databases showing XKR8

Other Databases showing XKR8

Specialized Databases showing XKR8

Licensable Technologiesfor XKR8

Servicesfor XKR8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XKR8

Summaries
for XKR8

Genomic Location
for XKR8

Proteins
for XKR8

Protein Domains/
Families
for XKR8

Gene Function
for XKR8

Pathways & Interactions
for XKR8

Drugs & Compounds
for XKR8

Transcripts
for XKR8

Expression
for XKR8

Orthologs
for XKR8

Paralogs
for XKR8

SNPs/Variants
for XKR8

Disorders & Mutations
for XKR8

Medical News
for XKR8

Publications
for XKR8

Licensable Technologies
for XKR8

Services
for XKR8