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Aliases for XKR7 Gene

Aliases for XKR7 Gene

  • XK Related 7 2 3 5
  • XK, Kell Blood Group Complex Subunit-Related Family, Member 7 2 3
  • X Kell Blood Group Precursor-Related Family, Member 7 2 3
  • C20orf159 3 4
  • Chromosome 20 Open Reading Frame 159 2
  • X-Linked Kx Blood Group Related 7 3
  • XK-Related Protein 7 3
  • DJ310O13.4 3
  • XRG7 4

External Ids for XKR7 Gene

Previous HGNC Symbols for XKR7 Gene

  • C20orf159

Previous GeneCards Identifiers for XKR7 Gene

  • GC20P030020
  • GC20P030555
  • GC20P027344

Summaries for XKR7 Gene

GeneCards Summary for XKR7 Gene

XKR7 (XK Related 7) is a Protein Coding gene. An important paralog of this gene is XKR4.

Additional gene information for XKR7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR7 Gene

Genomics for XKR7 Gene

GeneHancer (GH) Regulatory Elements for XKR7 Gene

Promoters and enhancers for XKR7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I031967 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 138 0.5 ATF1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF213 ELK1 ZNF143 ATF7 PDRG1 XKR7
GH20I031968 Enhancer 1.3 ENCODE dbSUPER 550.8 +0.6 551 0.2 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF213 E2F8 ZNF143 ENSG00000278012 PDRG1 XKR7 RSL24D1P6 FOXS1 TTLL9
GH20I031950 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 35.5 -16.5 -16497 2.4 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 PDRG1 XKR7 DUSP15 TTLL9 PIR49802
GH20I031840 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.3 -124.0 -123967 6.6 HDGF PKNOX1 SIN3A YBX1 ZNF48 TCF12 GLIS2 ZNF207 ZNF143 ATF7 GC20M031845 FOXS1 ASXL1 MYLK2 POFUT1 TSPY26P TTLL9 TM9SF4 BAK1P1 PLAGL2
GH20I032017 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 11.6 +50.7 50686 1.8 ARID4B SIN3A RAD21 ZNF48 ZNF335 GLIS2 EGR1 ZNF143 CREM KLF13 XKR7 MYLK2 CCM2L ENSG00000226239
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XKR7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XKR7 gene promoter:

Genomic Locations for XKR7 Gene

Genomic Locations for XKR7 Gene
chr20:31,968,002-32,003,387
(GRCh38/hg38)
Size:
35,386 bases
Orientation:
Plus strand
chr20:30,555,805-30,591,190
(GRCh37/hg19)

Genomic View for XKR7 Gene

Genes around XKR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR7 Gene

Proteins for XKR7 Gene

  • Protein details for XKR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GH72-XKR7_HUMAN
    Recommended name:
    XK-related protein 7
    Protein Accession:
    Q5GH72
    Secondary Accessions:
    • Q9NUG5

    Protein attributes for XKR7 Gene

    Size:
    579 amino acids
    Molecular mass:
    63826 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XKR7 Gene

Post-translational modifications for XKR7 Gene

No Post-translational modifications

Other Protein References for XKR7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKR7 Gene

Domains & Families for XKR7 Gene

Gene Families for XKR7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for XKR7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XKR7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GH72

UniProtKB/Swiss-Prot:

XKR7_HUMAN :
  • Belongs to the XK family.
Family:
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR7: view

Function for XKR7 Gene

Phenotypes From GWAS Catalog for XKR7 Gene

Phenotypes for XKR7 Gene

GenomeRNAi human phenotypes for XKR7:
genes like me logo Genes that share phenotypes with XKR7: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XKR7 Gene

Localization for XKR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XKR7 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for XKR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for XKR7 Gene

Pathways & Interactions for XKR7 Gene

No Data Available

Interacting Proteins for XKR7 Gene

Gene Ontology (GO) - Biological Process for XKR7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for XKR7 Gene

Drugs & Compounds for XKR7 Gene

No Compound Related Data Available

Transcripts for XKR7 Gene

mRNA/cDNA for XKR7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR7 Gene

XK, Kell blood group complex subunit-related family, member 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKR7 Gene

No ASD Table

Relevant External Links for XKR7 Gene

GeneLoc Exon Structure for
XKR7
ECgene alternative splicing isoforms for
XKR7

Expression for XKR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XKR7 Gene

mRNA differential expression in normal tissues according to GTEx for XKR7 Gene

This gene is overexpressed in Brain - Cerebellum (x17.4), Brain - Cerebellar Hemisphere (x15.2), and Pituitary (x6.8).

Protein differential expression in normal tissues from HIPED for XKR7 Gene

This gene is overexpressed in Cerebrospinal fluid (51.4) and Fetal Brain (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for XKR7 Gene



Protein tissue co-expression partners for XKR7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XKR7 Gene:

XKR7

SOURCE GeneReport for Unigene cluster for XKR7 Gene:

Hs.666444
genes like me logo Genes that share expression patterns with XKR7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XKR7 Gene

Orthologs for XKR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for XKR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XKR7 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia XKR7 33 34
  • 92.63 (n)
cow
(Bos Taurus)
Mammalia XKR7 33 34
  • 91.25 (n)
rat
(Rattus norvegicus)
Mammalia Xkr7 33
  • 88.31 (n)
mouse
(Mus musculus)
Mammalia Xkr7 33 16 34
  • 88.08 (n)
oppossum
(Monodelphis domestica)
Mammalia XKR7 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves XKR7 33 34
  • 78.05 (n)
lizard
(Anolis carolinensis)
Reptilia XKR7 34
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:198371 33
  • 65.82 (n)
xkr7 34
  • 63 (a)
OneToMany
XKR7 (2 of 2) 34
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32579 34
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-8 34
  • 22 (a)
OneToMany
Species where no ortholog for XKR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for XKR7 Gene

ENSEMBL:
Gene Tree for XKR7 (if available)
TreeFam:
Gene Tree for XKR7 (if available)

Paralogs for XKR7 Gene

Paralogs for XKR7 Gene

(3) SIMAP similar genes for XKR7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XKR7: view

Variants for XKR7 Gene

Sequence variations from dbSNP and Humsavar for XKR7 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000004304 -- 31,998,034(+) G/A 3_prime_UTR_variant
rs1000022923 -- 31,981,918(+) A/G intron_variant
rs1000039415 -- 31,967,064(+) C/G upstream_transcript_variant
rs1000093065 -- 31,992,527(+) A/G intron_variant
rs1000209746 -- 31,968,681(+) A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for XKR7 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
esv2637856 CNV loss 19546169
esv29218 CNV loss 19812545
esv3362843 CNV duplication 20981092
esv3445872 CNV duplication 20981092
nsv1110371 CNV duplication 24896259
nsv1153277 CNV duplication 26484159
nsv3348 CNV deletion 18451855
nsv833952 CNV gain 17160897

Variation tolerance for XKR7 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XKR7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XKR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR7 Gene

Disorders for XKR7 Gene

Additional Disease Information for XKR7

No disorders were found for XKR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XKR7 Gene

Publications for XKR7 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for XKR7 Gene

Sources for XKR7 Gene

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