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XKR7 Gene

protein-coding   GIFtS: 38

GC20P030020
XK, Kell blood group complex subunit-related family, member 7
(Previous names: X Kell blood group precursor-related family, member 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for XKR7

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C20orf159 2, 3
XRG7 3
dJ310O13.4 2
Descriptions
X Kell blood group precursor-related family, member 7 1, 2
XK, Kell blood group complex subunit-related family, member
7 2
XK-related protein 7 2
External Ids
HGNC: 230621
Entrez Gene: 3437022
UniProtKB: Q5GH723
Ensembl: ENSG000001013217
Search outside databases for aliases for XKR7 gene

Summaries
for XKR7

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for XKR7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XKR7 gene  

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

XKR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P030020:     (about GC identifiers)

Start:
 30,019,466 bp from pter
End:
 30,049,917 bp from pter
Size:
 30,452 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000020.9  NT_028392.5  

Proteins
for XKR7

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: XKR7_HUMAN, Q5GH72 (See protein sequence)
Recommended Name: XK-related protein 7  
Size: 579 amino acids; 63826 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q9NUG5

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_001011718.1  

    ENSEMBL proteins: 
    ENSP00000217299 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for XKR7: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for XKR7

    Assays for XKR7: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for XKR7

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR000048 IQ_CaM_bd_region
     IPR018629 Membr_transp_prot_XK-like


       GeneDecks  XKR7 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5GH72

    ProtoNet protein and cluster: Q5GH72

    UniProtKB/Swiss-Prot: XKR7_HUMAN, Q5GH72
    Similarity: Belongs to the XK family

    Gene Function
    for XKR7

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (XKR7)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_293160

                  Applied Biosystems Silencer® siRNAs for XKR7

                  Sigma-Aldrich siRNA for XKR7  
                         Sigma-Aldrich shRNA for XKR7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001011718
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001011718
                                     untagged cDNA clone in CMV expression vector: NM_001011718 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001011718

    Pathways & Interactions
    for XKR7

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    Drugs & Compounds
    for XKR7

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XKR7

    Transcripts
    for XKR7

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (XKR7)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_293160

                  Sigma-Aldrich siRNA for XKR7  
                         Sigma-Aldrich shRNA for XKR7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001011718  

    REFSEQ mRNAs for XKR7 gene: 

    NM_001011718.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001011718  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001011718
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001011718
                                     untagged cDNA clone in CMV expression vector: NM_001011718 

    Additional cDNA sequence: AY534245.1 

    1 DOTS entry:

    DT.40220862 

    1 AceView cDNA sequence:

    BM461448 

    highest scoring ESTs for XKR7:

    AA976188 AI655389 AY534245 BE504230 BM461448 BX279951 NM_001011718 

    Unigene Cluster for XKR7:

    XK, Kell blood group complex subunit-related family, member 7
    Hs.666444  [show with all ESTs]
    Unigene Representative Sequence: AY534245


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000217299  

    Expression
    for XKR7

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XKR7 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XKR7

    1Data from GNF BioGPS
        About these images

    About these images

    CGAP SAGE TAG: GAGGGGTGGA

    SOURCE GeneReport for Unigene cluster: Hs.666444

    Orthologs
    for XKR7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for XKR7 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 XKR71   -- XK, Kell blood group complex subunit-related family, more 92.06(n)
    93.09(a)    		 485827  XM_542951.2  XP_542951.2 
    chimpanzee
    (Pan troglodytes)    		 XKR71   -- XK, Kell blood group complex subunit-related family, more 99.42(n)
    99.14(a)    		 458161  NM_001033034.1  NP_001028206.1 
    cow
    (Bos taurus)    		 XKR71   -- XK, Kell blood group complex subunit-related family, more 91.19(n)
    92.23(a)    		 518090  XM_596274.2  XP_596274.2 
    rat
    (Rattus norvegicus)    		 Xkr71   -- XK, Kell blood group complex subunit-related family, more 88.31(n)
    91.19(a)    		 311549  NM_001012092.1  NP_001012092.1 
    mouse
    (Mus musculus)    		 Xkr71, 5 25
    		 X Kell blood group precursor related family member more1, 5 88.08(n)1
    91.19(a)1    		 2287871  NM_001011732.11  NP_001011732.11 
     AL9288625  AY5342535 
    About this table        Species with no ortholog for XKR7

    ENSEMBL Gene Tree for XKR7

    Paralogs
    for XKR7

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for XKR7 gene
    XKR62  XKR52  XKR42  

    SNPs/Variants
    for XKR7

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/149 NCBI SNPs in XKR7 are shown (see all 149 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 36)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs7146051,2
    		A,C,F,H30049685(+) GATGAA/GGTTCC 1 -- ut3113Minor allele frequency- N:0.00MN EU EA WA NA 1184
    --
    rs7146041,2
    		A,F30049423(+) ATGGCG/ATGGCT 1 -- ut31 ese31Minor allele frequency- A:0.48MN 184
    rs61213041,2
    		H30049184(+) TTTTCG/AAGCTG 1 -- ut314Minor allele frequency- A:0.00EU EA WA 402
    --
    rs75090361,2
    		A30049804(+) AGATCC/TCTGGG 1 -- ut31 ese30--------
    rs60610691,2
    		A,C,F,H30026261(+) TACAGT/CCCCCT 1 -- int14Minor allele frequency- C:0.38EU EA WA 412
    --
    rs60878041,2
    		A,C,F,H30024599(+) CCATCA/GTTAAA 1 -- int13Minor allele frequency- G:0.16EU EA 300
    rs60891411,2
    		A,C,F,H30042269(+) CATTTC/TCCTAG 1 -- int112Minor allele frequency- N:0.00EU EA WA NA 1052
    rs60891401,2
    		A,C,F,H30042128(+) ATGACT/CAGATA 1 -- int17Minor allele frequency- C:0.36EU EA WA NA 546
    rs61197471,2
    		C,F,H30029357(+) CTGTAT/GCAGGG 1 -- int112Minor allele frequency- G:0.44EU EA WA 1250
    --
    rs50287041,2
    		A,F,H30039143(+) ACAGAC/GAGACA 1 -- int12Minor allele frequency- G:0.30EU WA 240
    About this table

    HapMap Linkage Disequilibrium images for XKR7 (up to first 250kb)

    Disorders & Mutations
    for XKR7

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for XKR7

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for XKR7

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		2 PubMed articles for XKR7 gene:

    Search for XKR7

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing XKR7

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 343702 HGNC: 23062 AceView: LOC343702.1 Ensembl:ENSG00000101321 euGenes: HUgn343702
    ECgene: XKR7 H-InvDB: XKR7

    Other Databases showing XKR7

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing XKR7

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for XKR7

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for XKR7

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XKR7:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XKR7-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for XKR7 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for XKR7 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search Novus for antibodies for XKR7

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