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Aliases for XKR7 Gene

Aliases for XKR7 Gene

  • XK Related 7 2 3 5
  • XK, Kell Blood Group Complex Subunit-Related Family, Member 7 2 3
  • X Kell Blood Group Precursor-Related Family, Member 7 2 3
  • C20orf159 3 4
  • Chromosome 20 Open Reading Frame 159 2
  • X-Linked Kx Blood Group Related 7 3
  • XK-Related Protein 7 3
  • DJ310O13.4 3
  • XRG7 4

External Ids for XKR7 Gene

Previous HGNC Symbols for XKR7 Gene

  • C20orf159

Previous GeneCards Identifiers for XKR7 Gene

  • GC20P030020
  • GC20P030555
  • GC20P027344

Summaries for XKR7 Gene

GeneCards Summary for XKR7 Gene

XKR7 (XK Related 7) is a Protein Coding gene. An important paralog of this gene is XKR4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR7 Gene

Genomics for XKR7 Gene

Regulatory Elements for XKR7 Gene

Enhancers for XKR7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G031950 1.4 FANTOM5 ENCODE 35.5 -16.5 -16498 2.4 PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YBX1 FEZF1 YY1 XKR7 DUSP15 TTLL9 PIR49802
GH20G031840 1.5 Ensembl ENCODE dbSUPER 11.3 -124.0 -123968 6.6 HDGF PKNOX1 YBX1 ZNF48 TCF12 GLIS2 ZNF207 ZNF143 FOS DEK MYLK2 TSPY26P BAK1P1 TTLL9 DUSP15 XKR7 PLAGL2 HM13 COX4I2 GC20M031845
GH20G031835 1.5 Ensembl ENCODE dbSUPER 11.1 -130.8 -130798 3.8 PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 TCF12 GLIS2 CBX5 GATA2 DUSP15 TTLL9 XKR7 TM9SF4 HM13 GC20M031845 MYLK2
GH20G031972 0.7 ENCODE dbSUPER 20.5 +4.7 4663 1.0 ZKSCAN8 REST EZH2 XKR7 CCM2L RNA5SP481 RNU1-94P MYLK2 HCK RNA5SP482 ENSG00000278012 GC20P031999
GH20G031809 1.3 Ensembl ENCODE dbSUPER 11 -156.5 -156456 3.6 HDAC1 ESRRA ATF1 JUN KLF17 ZIC2 HIC1 TCF12 GATA2 ZSCAN29 DUSP15 TTLL9 XKR7 TPX2 TM9SF4 COX4I2 ENSG00000230801 MYLK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XKR7 on UCSC Golden Path with GeneCards custom track

Promoters for XKR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136071 198 401 ATF1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ELK1 ZNF143

Genomic Location for XKR7 Gene

Chromosome:
20
Start:
31,968,002 bp from pter
End:
32,003,387 bp from pter
Size:
35,386 bases
Orientation:
Plus strand

Genomic View for XKR7 Gene

Genes around XKR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR7 Gene

Proteins for XKR7 Gene

  • Protein details for XKR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GH72-XKR7_HUMAN
    Recommended name:
    XK-related protein 7
    Protein Accession:
    Q5GH72
    Secondary Accessions:
    • Q9NUG5

    Protein attributes for XKR7 Gene

    Size:
    579 amino acids
    Molecular mass:
    63826 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XKR7 Gene

Post-translational modifications for XKR7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKR7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKR7 Gene

Domains & Families for XKR7 Gene

Gene Families for XKR7 Gene

Protein Domains for XKR7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XKR7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GH72

UniProtKB/Swiss-Prot:

XKR7_HUMAN :
  • Belongs to the XK family.
Family:
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR7: view

Function for XKR7 Gene

Phenotypes for XKR7 Gene

GenomeRNAi human phenotypes for XKR7:
genes like me logo Genes that share phenotypes with XKR7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XKR7 Gene

Localization for XKR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XKR7 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for XKR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR7: view

Pathways & Interactions for XKR7 Gene

No Data Available

Interacting Proteins for XKR7 Gene

Gene Ontology (GO) - Biological Process for XKR7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for XKR7 Gene

Drugs & Compounds for XKR7 Gene

No Compound Related Data Available

Transcripts for XKR7 Gene

mRNA/cDNA for XKR7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR7 Gene

XK, Kell blood group complex subunit-related family, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKR7 Gene

No ASD Table

Relevant External Links for XKR7 Gene

GeneLoc Exon Structure for
XKR7
ECgene alternative splicing isoforms for
XKR7

Expression for XKR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XKR7 Gene

mRNA differential expression in normal tissues according to GTEx for XKR7 Gene

This gene is overexpressed in Brain - Cerebellum (x17.4), Brain - Cerebellar Hemisphere (x15.2), and Pituitary (x6.8).

Protein differential expression in normal tissues from HIPED for XKR7 Gene

This gene is overexpressed in Cerebrospinal fluid (51.4) and Fetal Brain (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for XKR7 Gene



Protein tissue co-expression partners for XKR7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XKR7 Gene:

XKR7

SOURCE GeneReport for Unigene cluster for XKR7 Gene:

Hs.666444
genes like me logo Genes that share expression patterns with XKR7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XKR7 Gene

Orthologs for XKR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for XKR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XKR7 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia XKR7 34 35
  • 92.63 (n)
cow
(Bos Taurus)
Mammalia XKR7 34 35
  • 91.25 (n)
rat
(Rattus norvegicus)
Mammalia Xkr7 34
  • 88.31 (n)
mouse
(Mus musculus)
Mammalia Xkr7 34 16 35
  • 88.08 (n)
oppossum
(Monodelphis domestica)
Mammalia XKR7 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves XKR7 34 35
  • 78.05 (n)
lizard
(Anolis carolinensis)
Reptilia XKR7 35
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:198371 34
  • 65.82 (n)
xkr7 35
  • 63 (a)
OneToMany
XKR7 (2 of 2) 35
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32579 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-8 35
  • 22 (a)
OneToMany
Species where no ortholog for XKR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for XKR7 Gene

ENSEMBL:
Gene Tree for XKR7 (if available)
TreeFam:
Gene Tree for XKR7 (if available)

Paralogs for XKR7 Gene

Paralogs for XKR7 Gene

(3) SIMAP similar genes for XKR7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XKR7: view

Variants for XKR7 Gene

Sequence variations from dbSNP and Humsavar for XKR7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000004304 -- 31,998,034(+) AGGGT(A/G)TTGGG utr-variant-3-prime
rs1000022923 -- 31,981,918(+) CTCCT(A/G)TGTCT intron-variant
rs1000039415 -- 31,967,064(+) AAAGG(C/G)AGAGA upstream-variant-2KB
rs1000093065 -- 31,992,527(+) TAGAT(A/G)CACCA intron-variant
rs1000209746 -- 31,968,681(+) CGCCT(A/C)CCGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for XKR7 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
esv2637856 CNV loss 19546169
esv29218 CNV loss 19812545
esv3362843 CNV duplication 20981092
esv3445872 CNV duplication 20981092
nsv1110371 CNV duplication 24896259
nsv1153277 CNV duplication 26484159
nsv3348 CNV deletion 18451855
nsv833952 CNV gain 17160897

Variation tolerance for XKR7 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XKR7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XKR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR7 Gene

Disorders for XKR7 Gene

Relevant External Links for XKR7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XKR7

No disorders were found for XKR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XKR7 Gene

Publications for XKR7 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for XKR7 Gene

Sources for XKR7 Gene

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