XKR6 Gene
protein-coding GIFtS: 45
GCID: GC08M010794
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XK, Kell blood group complex subunit-related family, member...(Previous names: chromosome 8 open reading frame 7, chromosome 8 open reading...)
(Previous symbols: C8orf7, C8orf21, C8orf5)
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Aliases
for XKR6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| XK, Kell Blood Group Complex Subunit-Related Family, Member 61 2 | | Chromosome 8 Open Reading Frame 211 | | C8orf211 2 3 | | Chromosome 8 Open Reading Frame 51 | | C8orf51 2 3 | | Chromosome 8 Open Reading Frame 71 | | C8orf71 2 3 | | Transmembrane Protein C8orf52 | | X Kell Blood Group Precursor-Related Family, Member 61 2 | | XK-Related Protein 62 | | XRG62 3 | | |
Export aliases for XKR6 gene to outside databasesPrevious GC identifer: GC08M009683 |
Summaries
for XKR6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for XKR6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_077531.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XKR6 gene promoter:
RP58 RREB-1 FOXO3 Tal-1beta FOXO3b RORalpha1 c-Rel FOXO3a NF-kappaB1 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for XKR6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKR6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1XKR6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M010794: view genomic region
(about GC identifiers)
Start:
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10,753,555 bp from pter |
End:
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11,058,875 bp from pter |
Size:
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305,321 bases |
Orientation:
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minus strand |
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Proteins
for XKR6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XKR6_HUMAN, Q5GH73 (See
protein sequence)Recommended Name: XK-related protein 6 Size: 641 amino acids; 71638 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q8TBA0Alternative splicing: 2 isoforms: Q5GH73-1 Q5GH73-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for XKR6: NX_Q5GH73
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5GH73
XKR6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775954.2
ENSEMBL proteins: ENSP00000371900 ENSP00000416707 ENSP00000436594 ENSP00000297303 ENSP00000307120
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
XKR6 for ontologies About GeneDecksing
XKR6 Antibody Products:
Assay Products for XKR6: |
Protein
Domains /
Families
for XKR6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XKR6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5GH73ProtoNet protein and cluster: Q5GH73 UniProtKB/Swiss-Prot: XKR6_HUMAN, Q5GH73Similarity: Belongs to the XK family |
Function
for XKR6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XKR6 (NM_173683) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKR6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR6 |
2 GenomeRNAi human phenotypes for XKR6:
|
Pathways & Interactions
for XKR6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XKR6
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for XKR6 (ENSP000004167074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for XKR6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XKR6
Search CenterWatch for drugs/clinical trials and news about XKR6
|
Transcripts
for XKR6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XKR6 gene: NM_173683.3 Unigene Clusters for XKR6: XK, Kell blood group complex subunit-related family, member 6 Hs.657083 [show with all ESTs], Hs.665456 [show with all ESTs], Hs.666146 [show with all ESTs]Unigene Representative Sequences: AJ305312, AK056119, NM_1736835 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382461 ENST00000416569(uc003wtk.1) ENST00000529336 ENST00000297303
ENST00000304437
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XKR6 (NM_173683) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKR6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR6 |
Additional cDNA sequence: AJ301560.1 AY534244.1 BC024146.2 5 DOTS entries: DT.95098285 DT.425308 DT.97831824 DT.204001 DT.91750546 10 AceView cDNA sequences: AJ301560 NM_173683 BC024146 BM682977 BM718993 CA430193 BE561717 AA889040 BM701602 BF877724
GeneLoc Exon Structure
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Expression
for XKR6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XKR6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACAGGATA
About this image
See XKR6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XKR6
SOURCE GeneReport for Unigene clusters: Hs.657083 Hs.665456 Hs.666146
SABiosciences Custom PCR Arrays for XKR6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKR6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XKR6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKR6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKR6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR6 |
Orthologs
for XKR6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for XKR6 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for XKR6 (if available)
TreeFam Gene Tree for XKR6 (if available) |
Paralogs
for XKR6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XKR6 gene
- XKR82 XKR72 XKR92 XKR42
3 SIMAP similar genes for XKR6 using alignment to 3 protein entries: XKR6_HUMAN (see all proteins):C8orf7 XKR7 XKR4
XKR6 for paralogs About GeneDecksing
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Genomic Variants
for XKR6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XKR6 (10753555 - 11003555 bp, first 250kb of XKR6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 24 variations for XKR6
4 CNVs: 52342 70279 52343 52339
4 Indels: 47432 13024 100269 52344
15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XKR6 |
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Disorders
/ Diseases
for XKR6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XKR6 for disorders About GeneDecksing
2  diseases for XKR6: About MalaCardskeratolytic winter erythema cholesterol
1 disease from the University of Copenhagen DISEASES database for XKR6:Hydrocele Human Genome Epidemiology (HuGE) Navigator: XKR6 (5 documents)
Export disorders for XKR6 gene to outside databases
|
Publications
for XKR6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XKR6 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with XKR6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PubMed id 20972250)1 Park M.H....Park H.Y. (2011)
- Investigation of variants identified in caucasian gen ome-wide association studies for plasma high-density lipoprotein cholesterol an d triglycerides levels in Mexican dyslipidemic study samples. (PubMed id 20160193)1 Weissglas-Volkov D....Pajukanta P. (2010)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- A targeted association study in systemic lupus erythe matosus identifies multiple susceptibility alleles. (PubMed id 20962850)1 Budarf M.L....Rioux J.D. (2010)
- Four novel Loci (19q13, 6q24, 12q24, and 5q14) influe nce the microcirculation in vivo. (PubMed id 21060863)1 Ikram M.K....Wong T.Y. (2010)
- Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1 Kathiresan S....Cupples L.A. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for XKR6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing XKR6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XKR6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XKR6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for XKR6 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for XKR6 gene:
Search GeneIP for patents involving XKR6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XKR6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XKR6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XKR6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKR6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XKR6 | | OriGene 3'-UTR Clone for XKR6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XKR6 | | OriGene Custom Protein Services for XKR6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XKR6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XKR6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKR6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XKR6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKR6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKR6 |
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| | | | Search Tocris compounds for XKR6 |
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 | | | XKR6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR6 |
|  |  |  | | | | Search ThermoFisher Antibodies for XKR6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR6 |
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