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XKR6 Gene

protein-coding   GIFtS: 40

GC08M010794
XK, Kell blood group complex subunit-related family, member 6
(Previous names: chromosome 8 open reading frame 7, chromosome 8 open reading frame 21, X Kell blood group precursor-related family, member 6, chromosome 8 open reading frame 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: C8orf7, C8orf21, C8orf5)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
C8orf21 2, 3
C8orf5 2
C8orf7 2, 3
XRG6 2, 3
Descriptions
X Kell blood group precursor-related family, member 6 1, 2
XK, Kell blood group complex subunit-related family, member
6 2
XK-related protein 6 2
chromosome 8 open reading frame 21 1
chromosome 8 open reading frame 5 1
chromosome 8 open reading frame 7 1
External Ids
HGNC: 278061
Entrez Gene: 2860462
UniProtKB: Q5GH733
Ensembl: ENSG000001710447
Search outside databases for aliases for XKR6 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XKR6 gene  

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

XKR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M010794:     (about GC identifiers)

Start:
10,791,064 bp from pter
End:
11,096,285 bp from pter
Size:
305,222 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000008.9  NT_077531.3  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XKR6_HUMAN, Q5GH73 (See protein sequence)
Recommended Name: XK-related protein 6  
Size: 641 amino acids; 71638 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q8TBA0
Alternative splicing: 2 isoforms:  Q5GH73-1   Q5GH73-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_775954.2  

    ENSEMBL proteins: 
    ENSP00000297303 ENSP00000307120 ENSP00000371900 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for XKR6: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for XKR6
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for XKR6

    Assays for XKR6: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro domain/family:
     IPR018629 Membr_transp_prot_XK-like


       GeneDecks  XKR6 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5GH73

    ProtoNet protein and cluster: Q5GH73

    UniProtKB/Swiss-Prot: XKR6_HUMAN, Q5GH73
    Similarity: Belongs to the XK family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XKR6)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_088376

                  Applied Biosystems Silencer® siRNAs for XKR6

                  Sigma-Aldrich siRNA for XKR6  
                         Sigma-Aldrich shRNA for XKR6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for XKR6
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_173683
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_173683
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_173683 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_173683

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XKR6

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (XKR6)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_088376

                  Sigma-Aldrich siRNA for XKR6  
                         Sigma-Aldrich shRNA for XKR6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_173683  

    REFSEQ mRNAs for XKR6 gene: 

    NM_173683.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_173683  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_173683
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_173683
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_173683 

    Additional cDNA sequence: 

    AJ301560.1 AY534244.1 BC024146.2 

    4 DOTS entries:

    DT.97831824  DT.204001  DT.91750546  DT.40200831 

    10 AceView cDNA sequences:

    BC024146 NM_173683 BM682977 AJ301560 BM718993 CA430193 BE561717 AA889040 
    BM701602 BF877724 

    highest scoring ESTs for XKR6:

    AJ301560 BC024146 BF877724 BM682977 BM718993 CA430193 NM_173683 AA889040 AW409298 BE561717 

    Unigene Cluster for XKR6:

    XK, Kell blood group complex subunit-related family, member 6
    Hs.666146  [show with all ESTs]
    Unigene Representative Sequence: NM_173683


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000297303  ENST00000304437  ENST00000382461  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XKR6 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XKR6

    1 / 2 / 3

    2 probe-sets matching XKR6 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1557436_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1553640_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGGGCGGGGG

    SOURCE GeneReport for Unigene cluster: Hs.666146
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for XKR6 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    XKR61   -- XK, Kell blood group complex subunit-related family, more 95.52(n)
    95.52(a)
    486082  XM_543208.2  XP_543208.2 
    chimpanzee
    (Pan troglodytes)
    XKR61   -- XK, Kell blood group complex subunit-related family, more 92.68(n)
    92.37(a)
    472695  XM_528067.2  XP_528067.2 
    cow
    (Bos taurus)
    XKR61   -- XK, Kell blood group complex subunit-related family, more 95.66(n)
    96.03(a)
    539914  XM_590278.3  XP_590278.3 
    rat
    (Rattus norvegicus)
    Xkr61   -- XK, Kell blood group complex subunit-related family, more 93.62(n)
    94.51(a)
    305960  NM_001012042.1  NP_001012042.1 
    mouse
    (Mus musculus)
    Xkr61, 5 145
    X Kell blood group precursor related family member more1, 5 92.45(n)1
    95.03(a)1
    2191491  NM_173393.11  NP_775569.11 
     AY5342525  BC0245025 
    About this table        Species with no ortholog for XKR6

    ENSEMBL Gene Tree for XKR6
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for XKR6 gene
    XKR72  XKR52  XKR42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1992 NCBI SNPs in XKR6 are shown (see all 1992 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 757)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs112500841,2
    A,C,F,H10790722(+) GCATAG/CAGTTT 1 -- ng517Minor allele frequency- C:0.32NA EU EA WA 560
    rs24097301,2
    A,C,F,H11098048(+) GAAACC/AAGCCA 1 -- ng314Minor allele frequency- A:0.22EU EA WA 418
    rs70149681,2
    C,F,H10791921(+) ACTGAT/CTATGT 1 -- ut314Minor allele frequency- C:0.10EU EA WA 416
    rs100951401,2
    F,H10792541(+) AGATAA/CCTCCT 1 -- ut314Minor allele frequency- C:0.05EU EA WA 418
    --
    rs112501211,2
    C11097721(+) TCTCCA/CTTCAC 1 -- ng310--------
    rs24097131,2
    A,C,F,H,O11047207(+) AGTTGC/TCCTTC 1 -- int111Minor allele frequency- T:0.36NA EU EA WA 974
    rs24096851,2
    A,C,F,H,O10946603(+) gactcC/Aattca 1 -- int113Minor allele frequency- A:0.49NS EU EA WA 938
    rs28982601,2
    A,C,F,H,O10976900(+) TTGTCG/TGCCTA 1 -- int16Minor allele frequency- T:0.31EU EA NA 436
    rs24097191,2
    A,C,F,H,O11054299(+) CCACAA/GTGCAG 1 -- int114Minor allele frequency- G:0.19NS EU EA WA NA 848
    rs24097101,2
    A,C,F,H,O11017231(+) GCTACA/GAAACT 1 -- int17Minor allele frequency- G:0.47EU EA WA NA 560
    About this table

    HapMap Linkage Disequilibrium images for XKR6 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    5 PubMed articles for XKR6 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 286046 HGNC: 27806 AceView: C8orf21andC8orf7 Ensembl:ENSG00000171044 euGenes: HUgn286046
    ECgene: XKR6 H-InvDB: XKR6
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
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      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XKR6:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XKR6-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for XKR6 Antibodies for XKR6
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