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Aliases for XKR6 Gene

Aliases for XKR6 Gene

  • XK, Kell Blood Group Complex Subunit-Related Family, Member 6 2 3
  • X Kell Blood Group Precursor-Related Family, Member 6 2 3
  • C8orf21 3 4
  • C8orf5 3 4
  • C8orf7 3 4
  • XRG6 3 4
  • Chromosome 8 Open Reading Frame 21 2
  • Chromosome 8 Open Reading Frame 7 2
  • Chromosome 8 Open Reading Frame 5 2
  • Transmembrane Protein C8orf5 3
  • XK-Related Protein 6 3

External Ids for XKR6 Gene

Previous HGNC Symbols for XKR6 Gene

  • C8orf7
  • C8orf21
  • C8orf5

Previous GeneCards Identifiers for XKR6 Gene

  • GC08M010794
  • GC08M009683

Summaries for XKR6 Gene

GeneCards Summary for XKR6 Gene

XKR6 (XK, Kell Blood Group Complex Subunit-Related Family, Member 6) is a Protein Coding gene. Diseases associated with XKR6 include keratolytic winter erythema and hydrocele. An important paralog of this gene is XKR9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR6 Gene

Genomics for XKR6 Gene

Regulatory Elements for XKR6 Gene

Genomic Location for XKR6 Gene

Start:
10,896,045 bp from pter
End:
11,201,366 bp from pter
Size:
305,322 bases
Orientation:
Minus strand

Genomic View for XKR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XKR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR6 Gene

Proteins for XKR6 Gene

  • Protein details for XKR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GH73-XKR6_HUMAN
    Recommended name:
    XK-related protein 6
    Protein Accession:
    Q5GH73
    Secondary Accessions:
    • Q8TBA0

    Protein attributes for XKR6 Gene

    Size:
    641 amino acids
    Molecular mass:
    71638 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for XKR6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XKR6 Gene

Proteomics data for XKR6 Gene at MOPED

Post-translational modifications for XKR6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKR6 Gene

No data available for DME Specific Peptides for XKR6 Gene

Domains for XKR6 Gene

Protein Domains for XKR6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XKR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GH73

UniProtKB/Swiss-Prot:

XKR6_HUMAN :
  • Q5GH73
Family:
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR6: view

No data available for Gene Families for XKR6 Gene

Function for XKR6 Gene

Phenotypes for XKR6 Gene

GenomeRNAi human phenotypes for XKR6:
genes like me logo Genes that share phenotypes with XKR6: view

miRNA for XKR6 Gene

miRTarBase miRNAs that target XKR6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for XKR6 Gene

Localization for XKR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XKR6 Gene COMPARTMENTS Subcellular localization image for XKR6 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for XKR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR6: view

Pathways for XKR6 Gene

SuperPathways for XKR6 Gene

No Data Available

Interacting Proteins for XKR6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000416707%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000416707 for XKR6 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for XKR6 Gene

None

No data available for Pathways by source for XKR6 Gene

Transcripts for XKR6 Gene

mRNA/cDNA for XKR6 Gene

(10) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR6 Gene

XK, Kell blood group complex subunit-related family, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XKR6 Gene

No ASD Table

Relevant External Links for XKR6 Gene

GeneLoc Exon Structure for
XKR6
ECgene alternative splicing isoforms for
XKR6

Expression for XKR6 Gene

mRNA expression in normal human tissues for XKR6 Gene

mRNA differential expression in normal tissues according to GTEx for XKR6 Gene

This gene is overexpressed in Testis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for XKR6 Gene

SOURCE GeneReport for Unigene cluster for XKR6 Gene Hs.657083

genes like me logo Genes that share expressions with XKR6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for XKR6 Gene

Orthologs for XKR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for XKR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XKR5 36
  • 18 (a)
ManyToMany
XKR6 35
  • 93.22 (n)
  • 92.13 (a)
cow
(Bos Taurus)
Mammalia XKR6 35
  • 95.66 (n)
  • 96.03 (a)
XKR6 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XKR6 35
  • 95.46 (n)
  • 95.81 (a)
XKR6 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xkr6 35
  • 92.62 (n)
  • 92.78 (a)
Xkr6 16
Xkr6 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XKR6 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Xkr6 35
  • 92.52 (n)
  • 92.78 (a)
chicken
(Gallus gallus)
Aves XKR6 35
  • 87.06 (n)
  • 91.53 (a)
XKR6 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XKR6 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17018 35
tropical clawed frog
(Silurana tropicalis)
Amphibia xkr6 35
  • 80.19 (n)
  • 84.64 (a)
zebrafish
(Danio rerio)
Actinopterygii xkr6 35
  • 71.99 (n)
  • 75.52 (a)
xkr6 36
  • 77 (a)
OneToMany
XKR6 (1 of 2) 36
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000599 35
  • 46.78 (n)
  • 31.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32579 35
  • 38.1 (n)
  • 27.44 (a)
CG32579 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-8 35
  • 42 (n)
  • 28.79 (a)
ced-8 36
  • 23 (a)
OneToMany
Species with no ortholog for XKR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XKR6 Gene

ENSEMBL:
Gene Tree for XKR6 (if available)
TreeFam:
Gene Tree for XKR6 (if available)

Paralogs for XKR6 Gene

Paralogs for XKR6 Gene

Selected SIMAP similar genes for XKR6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with XKR6: view

Variants for XKR6 Gene

Sequence variations from dbSNP and Humsavar for XKR6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1057625 -- 11,105,447(-) AAGGG(C/G)GCTTG intron-variant
rs1057626 -- 11,105,290(-) AATGT(A/G)TGTTC intron-variant
rs1806648 -- 11,082,946(-) GCCGC(A/G)GCAGC intron-variant
rs1962498 -- 11,182,010(+) gaact(C/G)ccaca intron-variant
rs1987190 -- 11,196,005(-) TGCTT(A/T)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XKR6 Gene

Variant ID Type Subtype PubMed ID
nsv831232 CNV Loss 17160897
nsv522127 CNV Loss 19592680
nsv521721 CNV Loss 19592680
dgv448n21 CNV Loss 19592680
esv2506669 CNV Insertion 19546169
esv25007 CNV Gain 19812545
esv2736599 CNV Deletion 23290073
esv1926132 CNV Deletion 18987734
esv1006630 CNV Insertion 20482838
esv1732990 CNV Insertion 17803354
esv2667237 CNV Deletion 23128226
nsv516033 CNV Loss 19592680
esv275517 CNV Gain+Loss 21479260
nsv519941 CNV Loss 19592680
nsv397981 CNV Loss 16902084
esv2147573 CNV Deletion 18987734
nsv831233 CNV Gain 17160897

Relevant External Links for XKR6 Gene

HapMap Linkage Disequilibrium report
XKR6
Human Gene Mutation Database (HGMD)
XKR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR6 Gene

Disorders for XKR6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for XKR6 Gene including...

Search for XKR6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for XKR6 Gene

Relevant External Links for XKR6

Genetic Association Database (GAD)
XKR6
Human Genome Epidemiology (HuGE) Navigator
XKR6
genes like me logo Genes that share disorders with XKR6: view

No data available for UniProtKB/Swiss-Prot for XKR6 Gene

Publications for XKR6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 48
  3. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. (PMID: 20160193) Weissglas-Volkov D. … Pajukanta P. (Circ Cardiovasc Genet 2010) 3 48
  4. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf M.L. … Rioux J.D. (Genes Immun. 2011) 3 48
  5. Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PMID: 20972250) Park M.H. … Park H.Y. (J. Med. Genet. 2011) 3

Products for XKR6 Gene

Sources for XKR6 Gene

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