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XKR6 Gene

protein-coding GIFtS: 40

GC08M010794

XK, Kell blood group complex subunit-related family, member 6
(Previous names: chromosome 8 open reading frame 7, chromosome 8 open reading frame 21, X Kell blood group precursor-related family, member 6, chromosome 8 open reading frame 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: C8orf7, C8orf21, C8orf5)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C8orf21 ^², ³
C8orf5 ^²
C8orf7 ^², ³
XRG6 ^², ³

Descriptions
X Kell blood group precursor-related family, member 6 ^¹, ²
XK, Kell blood group complex subunit-related family, member 6 ^²
XK-related protein 6 ^²
chromosome 8 open reading frame 21 ^¹
chromosome 8 open reading frame 5 ^¹
chromosome 8 open reading frame 7 ^¹

External Ids
HGNC: 27806¹
Entrez Gene: 286046²
UniProtKB: Q5GH73³
Ensembl: ENSG00000171044⁷

Search outside databases for aliases for XKR6 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XKR6 gene

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

XKR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M010794: (about GC identifiers)

Start:	10,791,064 bp from pter
End:	11,096,285 bp from pter
Size:	305,222 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_077531.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XKR6_HUMAN, Q5GH73 (See protein sequence)

Recommended Name: XK-related protein 6

Size: 641 amino acids; 71638 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q8TBA0

Alternative splicing: 2 isoforms: Q5GH73-1 Q5GH73-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_775954.2

ENSEMBL proteins:

ENSP00000297303 ENSP00000307120 ENSP00000371900

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for XKR6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XKR6
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for XKR6

Assays for XKR6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q5GH73

ProtoNet protein and cluster: Q5GH73

UniProtKB/Swiss-Prot: XKR6_HUMAN, Q5GH73

Similarity: Belongs to the XK family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR6)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_088376

Applied Biosystems Silencer® siRNAs for XKR6

Sigma-Aldrich siRNA for XKR6

Sigma-Aldrich shRNA for XKR6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XKR6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_173683
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173683
untagged cDNA clones in CMV expression vector (see all 2): NM_173683

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173683

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XKR6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR6)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_088376

Sigma-Aldrich siRNA for XKR6

Sigma-Aldrich shRNA for XKR6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_173683

REFSEQ mRNAs for XKR6 gene:

NM_173683.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_173683

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173683
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173683
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_173683

Additional cDNA sequence:

AJ301560.1 AY534244.1 BC024146.2

4 DOTS entries:

DT.97831824 DT.204001 DT.91750546 DT.40200831

10 AceView cDNA sequences:

BC024146 NM_173683 BM682977 AJ301560 BM718993 CA430193 BE561717 AA889040

BM701602 BF877724

highest scoring ESTs for XKR6:

AJ301560 BC024146 BF877724 BM682977 BM718993 CA430193 NM_173683 AA889040 AW409298 BE561717

Unigene Cluster for XKR6:

XK, Kell blood group complex subunit-related family, member 6

Hs.666146 [show with all ESTs]

Unigene Representative Sequence: NM_173683

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000297303 ENST00000304437 ENST00000382461

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XKR6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XKR6

¹ / ² / ³

2 probe-sets matching XKR6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1557436_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553640_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGGCGGGGG

SOURCE GeneReport for Unigene cluster: Hs.666146

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XKR6 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XKR6¹	--	XK, Kell blood group complex subunit-related family, more	95.52(n) 95.52(a)	486082 XM_543208.2 XP_543208.2
chimpanzee (Pan troglodytes)	XKR6¹	--	XK, Kell blood group complex subunit-related family, more	92.68(n) 92.37(a)	472695 XM_528067.2 XP_528067.2
cow (Bos taurus)	XKR6¹	--	XK, Kell blood group complex subunit-related family, more	95.66(n) 96.03(a)	539914 XM_590278.3 XP_590278.3
rat (Rattus norvegicus)	Xkr6¹	--	XK, Kell blood group complex subunit-related family, more	93.62(n) 94.51(a)	305960 NM_001012042.1 NP_001012042.1
mouse (Mus musculus)	Xkr6^{1, 5}	14⁵	X Kell blood group precursor related family member more^{1, 5}	92.45(n)¹ 95.03(a)¹	219149¹ NM_173393.1¹ NP_775569.1¹ AY534252⁵ BC024502⁵

About this table Species with no ortholog for XKR6

ENSEMBL Gene Tree for XKR6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XKR6 gene

XKR7² XKR5² XKR4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1992 NCBI SNPs in XKR6 are shown (see all 1992 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 757)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11250084^1,2	A,C,F,H	10790722(+)	`GCATAG/CAGTTT`	1	--	ng5¹		7		NA EU EA WA	560
	rs2409730^1,2	A,C,F,H	11098048(+)	`GAAACC/AAGCCA`	1	--	ng3¹		4		EU EA WA	418
	rs7014968^1,2	C,F,H	10791921(+)	`ACTGAT/CTATGT`	1	--	ut3¹		4		EU EA WA	416
	rs10095140^1,2	F,H	10792541(+)	`AGATAA/CCTCCT`	1	--	ut3¹		4		EU EA WA	418
--	rs11250121^1,2	C	11097721(+)	`TCTCCA/CTTCAC`	1	--	ng3¹		0	--	--	--	--
	rs2409713^1,2	A,C,F,H,O	11047207(+)	`AGTTGC/TCCTTC`	1	--	int¹		11		NA EU EA WA	974
	rs2409685^1,2	A,C,F,H,O	10946603(+)	`gactcC/Aattca`	1	--	int¹		13		NS EU EA WA	938
	rs2898260^1,2	A,C,F,H,O	10976900(+)	`TTGTCG/TGCCTA`	1	--	int¹		6		EU EA NA	436
	rs2409719^1,2	A,C,F,H,O	11054299(+)	`CCACAA/GTGCAG`	1	--	int¹		14		NS EU EA WA NA	848
	rs2409710^1,2	A,C,F,H,O	11017231(+)	`GCTACA/GAAACT`	1	--	int¹		7		EU EA WA NA	560

About this table

HapMap Linkage Disequilibrium images for XKR6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for XKR6 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)³ Kathiresan S....Cupples L.A. (2009)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. (PubMed id 11896452)³ Appel S....Rosenthal A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 286046	HGNC: 27806	AceView: C8orf21andC8orf7	Ensembl:ENSG00000171044	euGenes: HUgn286046
ECgene: XKR6	H-InvDB: XKR6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for XKR6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for XKR6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XKR6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XKR6		Antibodies for XKR6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XKR6		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for XKR6

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XKR6 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for XKR6

Summaries
for XKR6

Genomic Location
for XKR6

Proteins
for XKR6

Protein Domains/
Families
for XKR6

Gene Function
for XKR6

Pathways & Interactions
for XKR6

Drugs & Compounds
for XKR6

Transcripts
for XKR6

Expression
for XKR6

Orthologs
for XKR6

Paralogs
for XKR6

SNPs/Variants
for XKR6

Disorders & Mutations
for XKR6

Medical News
for XKR6

Publications
for XKR6

Search for XKR6

Genome Databases showing XKR6

Other Databases showing XKR6

Specialized Databases showing XKR6

Licensable Technologies
for XKR6

Services
for XKR6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XKR6 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor XKR6

Summariesfor XKR6

Genomic Locationfor XKR6

Proteinsfor XKR6

Protein Domains/Familiesfor XKR6

Gene Functionfor XKR6

Pathways & Interactionsfor XKR6

Drugs & Compoundsfor XKR6

Transcriptsfor XKR6

Expression for XKR6

Orthologsfor XKR6

Paralogsfor XKR6

SNPs/Variantsfor XKR6

Disorders & Mutationsfor XKR6

Medical Newsfor XKR6

Publicationsfor XKR6

Search for XKR6

Genome Databases showing XKR6

Other Databases showing XKR6

Specialized Databases showing XKR6

Licensable Technologiesfor XKR6

Servicesfor XKR6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XKR6

Summaries
for XKR6

Genomic Location
for XKR6

Proteins
for XKR6

Protein Domains/
Families
for XKR6

Gene Function
for XKR6

Pathways & Interactions
for XKR6

Drugs & Compounds
for XKR6

Transcripts
for XKR6

Expression
for XKR6

Orthologs
for XKR6

Paralogs
for XKR6

SNPs/Variants
for XKR6

Disorders & Mutations
for XKR6

Medical News
for XKR6

Publications
for XKR6

Licensable Technologies
for XKR6

Services
for XKR6