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Aliases for XKR5 Gene

Aliases for XKR5 Gene

  • XK Related 5 2 3 5
  • XK, Kell Blood Group Complex Subunit-Related Family, Member 5 2 3
  • X Kell Blood Group Precursor-Related Family, Member 5 2 3
  • X-Linked Kx Blood Group Related 5 3
  • XK-Related Protein 5a 3
  • XK-Related Protein 5 3
  • HARL2754 3
  • UNQ2754 3
  • XRG5BM 3
  • XRG5A 3
  • XRG5 4

External Ids for XKR5 Gene

Previous GeneCards Identifiers for XKR5 Gene

  • GC08M006659
  • GC08M006446
  • GC08M006666

Summaries for XKR5 Gene

GeneCards Summary for XKR5 Gene

XKR5 (XK Related 5) is a Protein Coding gene. An important paralog of this gene is XKR7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR5 Gene

Genomics for XKR5 Gene

Regulatory Elements for XKR5 Gene

Enhancers for XKR5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F006840 0.9 Ensembl ENCODE 0.4 -5.4 -5386 1.5 ELF3 DRAP1 CTCF WRNIP1 MAX ZNF2 RAD21 ZNF101 ZFHX2 ZNF366 GS1-24F4.2 GC08M006794 XKR5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around XKR5 on UCSC Golden Path with GeneCards custom track

Promoters for XKR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for XKR5 Gene

6,808,517 bp from pter
6,835,644 bp from pter
27,128 bases
Minus strand

Genomic View for XKR5 Gene

Genes around XKR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR5 Gene

Proteins for XKR5 Gene

  • Protein details for XKR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    XK-related protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5GH74

    Protein attributes for XKR5 Gene

    686 amino acids
    Molecular mass:
    74982 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for XKR5 Gene


neXtProt entry for XKR5 Gene

Post-translational modifications for XKR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKR5 Gene

No data available for DME Specific Peptides for XKR5 Gene

Domains & Families for XKR5 Gene

Gene Families for XKR5 Gene

Protein Domains for XKR5 Gene


Suggested Antigen Peptide Sequences for XKR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the XK family.
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR5: view

Function for XKR5 Gene

genes like me logo Genes that share phenotypes with XKR5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XKR5 Gene

Localization for XKR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR5 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for XKR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR5: view

No data available for Subcellular locations from COMPARTMENTS for XKR5 Gene

Pathways & Interactions for XKR5 Gene

SuperPathways for XKR5 Gene

No Data Available

Interacting Proteins for XKR5 Gene

Gene Ontology (GO) - Biological Process for XKR5 Gene


No data available for Pathways by source and SIGNOR curated interactions for XKR5 Gene

Transcripts for XKR5 Gene

mRNA/cDNA for XKR5 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR5 Gene

XK, Kell blood group complex subunit-related family, member 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKR5 Gene

No ASD Table

Relevant External Links for XKR5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XKR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XKR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XKR5 Gene

This gene is overexpressed in Cervix - Endocervix (x17.5), Uterus (x5.7), Prostate (x5.4), and Cervix - Ectocervix (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of XKR5 Gene:


SOURCE GeneReport for Unigene cluster for XKR5 Gene:

genes like me logo Genes that share expression patterns with XKR5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for XKR5 Gene

Orthologs for XKR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XKR5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia XKR5 34
  • 98.54 (n)
(Mus musculus)
Mammalia Xkr5 34 16
  • 74.79 (n)
(Canis familiaris)
Mammalia XKR5 34
  • 73.37 (n)
(Rattus norvegicus)
Mammalia Xkr5 34
  • 73.06 (n)
(Bos Taurus)
Mammalia XKR5 34
  • 72.05 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia xkr5 34
  • 53.61 (n)
(Danio rerio)
Actinopterygii xrg5 34
  • 49.68 (n)
Species where no ortholog for XKR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XKR5 Gene

Gene Tree for XKR5 (if available)
Gene Tree for XKR5 (if available)

Paralogs for XKR5 Gene

Paralogs for XKR5 Gene

genes like me logo Genes that share paralogs with XKR5: view

Variants for XKR5 Gene

Sequence variations from dbSNP and Humsavar for XKR5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086142 -- 6,829,450(+) AAAAT(G/T)AACAT intron-variant
rs10091468 -- 6,818,354(+) CTTGT(G/T)TCCTG intron-variant, utr-variant-5-prime
rs10093421 -- 6,836,843(+) cttgg(C/G)agctt intron-variant, upstream-variant-2KB
rs10093919 -- 6,836,481(+) tggag(A/C)aggtg intron-variant, upstream-variant-2KB
rs10094139 -- 6,821,683(+) ACTAT(G/T)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XKR5 Gene

Variant ID Type Subtype PubMed ID
dgv6876n100 CNV loss 25217958
dgv6878n100 CNV gain 25217958
esv2422383 CNV duplication 17116639
esv2752262 CNV gain 17911159
esv3576520 CNV gain 25503493
nsv1015244 CNV gain 25217958
nsv1021684 CNV loss 25217958
nsv1025976 CNV loss 25217958
nsv1031577 CNV gain 25217958
nsv1117802 CNV deletion 24896259
nsv465436 CNV gain 19166990
nsv465437 CNV gain 19166990
nsv610004 CNV gain 21841781
nsv610006 CNV gain 21841781
nsv610007 CNV gain 21841781
nsv831220 CNV gain 17160897

Relevant External Links for XKR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for XKR5 Gene

Disorders for XKR5 Gene

Relevant External Links for XKR5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for XKR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XKR5 Gene

Publications for XKR5 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for XKR5 Gene

Sources for XKR5 Gene

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