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XKR5 Gene

protein-coding GIFtS: 40

GC08M006659

XK, Kell blood group complex subunit-related family, member 5
(Previous names: X Kell blood group precursor-related family, member 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
HARL2754 ^²
UNQ2754 ^²
XRG5 ^³
XRG5a ^²
XRG5b ^²

Descriptions
X Kell blood group precursor-related family, member 5 ^¹, ²
XK, Kell blood group complex subunit-related family, member 5 ^²
XK-related protein 5a ^²

External Ids
HGNC: 20782¹
Entrez Gene: 389610²
UniProtKB: Q6UX68³
Ensembl: ENSG00000186530⁷

Search outside databases for aliases for XKR5 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XKR5 gene

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

XKR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M006659: (about GC identifiers)

Start:	6,653,448 bp from pter
End:	6,680,576 bp from pter
Size:	27,129 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_023736.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XKR5_HUMAN, Q6UX68 (See protein sequence)

Recommended Name: XK-related protein 5

Size: 686 amino acids; 74982 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q5GH74

Alternative splicing: 2 isoforms: Q6UX68-1 Q6UX68-2

REFSEQ proteins: NP_997294.2

ENSEMBL proteins:

ENSP00000386256 ENSP00000385178 ENSP00000335064

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for XKR5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
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Assays for XKR5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6UX68

ProtoNet protein and cluster: Q6UX68

UniProtKB/Swiss-Prot: XKR5_HUMAN, Q6UX68

Similarity: Belongs to the XK family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XKR5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_207411

Applied Biosystems Silencer® siRNAs for XKR5

Sigma-Aldrich siRNA for XKR5

Sigma-Aldrich shRNA for XKR5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_207411
Myc/DDK tagged cDNA clone in CMV expression vector: NM_207411
untagged cDNA clone in CMV expression vector: NM_207411

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_207411

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XKR5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XKR5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_207411

Sigma-Aldrich siRNA for XKR5

Sigma-Aldrich shRNA for XKR5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_207411

REFSEQ mRNAs for XKR5 gene:

NM_207411.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_207411

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_207411
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_207411
                                 untagged cDNA clone in CMV expression vector: NM_207411

Additional cDNA sequence:

AY358489.1 AY534242.1 AY534243.1 CR604676.1

4 DOTS entries:

DT.101959721 DT.91692403 DT.91791975 DT.91874277

6 AceView cDNA sequences:

CR604676 BX368984 AL521639 NM_207411 AY358489 AL521638

highest scoring ESTs for XKR5:

AY358489 AL521639 AY534242 AY534243 CR604676 NM_207411 AL521638 BX368984 BE396631 BF903708

Unigene Cluster for XKR5:

XK, Kell blood group complex subunit-related family, member 5

Hs.558840 [show with all ESTs]

Unigene Representative Sequence: AY534242

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for XKR5

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10
SP1:																	-				-
SP2:							-										-				-
SP3:

About this scheme

ECgene alternative splicing isoforms for XKR5

3 Ensembl transcripts including schematic representations:

ENST00000409172 ENST00000405979 ENST00000334706

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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XKR5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XKR5

¹ Data from GNF BioGPS
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About these images

CGAP SAGE TAG: CCTCCAGAAA

SOURCE GeneReport for Unigene cluster: Hs.558840

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for XKR5 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XKR5¹	--	XK, Kell blood group complex subunit-related family, more	81.21(n) 76.95(a)	482942 XM_540057.2 XP_540057.2
chimpanzee (Pan troglodytes)	XKR5¹	--	XK, Kell blood group complex subunit-related family, more	98.62(n) 97.93(a)	463970 NM_001033035.1 NP_001028207.1
cow (Bos taurus)	XKR5¹	--	similar to XK-related protein 5a	78.27(n) 75.93(a)	529365 XM_607812.3 XP_607812.3
rat (Rattus norvegicus)	Xkr5¹	--	XK, Kell blood group complex subunit-related family, more	84.82(n) 81.3(a)	497083 NM_001012228.1 NP_001012228.1
mouse (Mus musculus)	Xkr5^{1, 5}	8⁵	X Kell blood group precursor-related family, member more^{1, 5}	74.17(n)¹ 71.52(a)¹	319581¹ NM_176951.3¹ NP_795925.1¹ AK030692⁵ AK045098⁵ (see all 9)

About this table Species with no ortholog for XKR5

ENSEMBL Gene Tree for XKR5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for XKR5 gene

XKR6² XKR7² XKR4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/304 NCBI SNPs in XKR5 are shown (see all 304 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 157)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2553722^1,2	A,C,F,H,O	6653101(-)	`CCCTTA/CGTGAA`	1	--	ng5¹		4	EU EA WA	418
	rs9772308^1,2	A,C,F,H	6681526(+)	`CAGAGG/AAAGGA`	1	--	ng3¹ trp³		8	EU EA WA	832
	rs2977802^1,2	A,C,F,H	6682255(-)	`TAAAAC/GTACCT`	1	--	ng3¹		8	EU EA WA	836
	rs9314611^1,2	A,C,F,H	6653994(+)	`GTGGAG/ATACAA`	1	--	ut3¹		8	EU EA WA	810
	rs2741098^1,2	A,C,F,H	6677686(+)	`CATCAC/TCAAGG`	1	M/V	mis¹		13	NA EU EA WA	1732
	rs2951851^1,2	A,C,F,H	6680905(+)	`CTGTGG/TCCAGA`	1	--	ng3¹		4	EU EA WA	418
	rs2977804^1,2	A,C,F	6681018(-)	`ATTGCC/GATCTT`	1	--	ng3¹		4	EA NA	204
	rs17078203^1,2	C,F,H	6653898(+)	`TTGGAG/ATTAGC`	1	--	ut3¹		11	NA EU EA WA	978
	rs2977809^1,2	C,F,O	6655893(-)	`GAGGAG/AGAGAA`	1	--	ut3¹		3	NA	142
	rs17078199^1,2	C,F,H	6653152(+)	`GTCCAC/TCTTTG`	1	--	ng5¹		12	NA EU EA WA	1026

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HapMap Linkage Disequilibrium images for XKR5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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2 PubMed articles for XKR5 gene:

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 389610	HGNC: 20782	AceView: UNQ2754	Ensembl:ENSG00000186530	euGenes: HUgn389610
ECgene: XKR5	H-InvDB: XKR5

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for XKR5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for XKR5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XKR5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XKR5		Browse antibodies at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Novus for antibodies for XKR5

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XKR5 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for XKR5

Summaries
for XKR5

Genomic Location
for XKR5

Proteins
for XKR5

Protein Domains/
Families
for XKR5

Gene Function
for XKR5

Pathways & Interactions
for XKR5

Drugs & Compounds
for XKR5

Transcripts
for XKR5

Expression
for XKR5

Orthologs
for XKR5

Paralogs
for XKR5

SNPs/Variants
for XKR5

Disorders & Mutations
for XKR5

Medical News
for XKR5

Publications
for XKR5

Search for XKR5

Genome Databases showing XKR5

Other Databases showing XKR5

Specialized Databases showing XKR5

Licensable Technologies
for XKR5

Services
for XKR5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XKR5 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor XKR5

Summariesfor XKR5

Genomic Locationfor XKR5

Proteinsfor XKR5

Protein Domains/Familiesfor XKR5

Gene Functionfor XKR5

Pathways & Interactionsfor XKR5

Drugs & Compoundsfor XKR5

Transcriptsfor XKR5

Expression for XKR5

Orthologsfor XKR5

Paralogsfor XKR5

SNPs/Variantsfor XKR5

Disorders & Mutationsfor XKR5

Medical Newsfor XKR5

Publicationsfor XKR5

Search for XKR5

Genome Databases showing XKR5

Other Databases showing XKR5

Specialized Databases showing XKR5

Licensable Technologiesfor XKR5

Servicesfor XKR5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XKR5

Summaries
for XKR5

Genomic Location
for XKR5

Proteins
for XKR5

Protein Domains/
Families
for XKR5

Gene Function
for XKR5

Pathways & Interactions
for XKR5

Drugs & Compounds
for XKR5

Transcripts
for XKR5

Expression
for XKR5

Orthologs
for XKR5

Paralogs
for XKR5

SNPs/Variants
for XKR5

Disorders & Mutations
for XKR5

Medical News
for XKR5

Publications
for XKR5

Licensable Technologies
for XKR5

Services
for XKR5