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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

XKR5 Gene

protein-coding GIFtS: 38
GCID: GC08M006666

XK, Kell blood group complex subunit-related family, member...

(Previous names: X Kell blood group precursor-related family, member 5 )

Search for XKR5
in

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
XK, Kell Blood Group Complex Subunit-Related Family, Member 5¹ ²		XRG5BM²
X Kell Blood Group Precursor-Related Family, Member 5¹ ²		XK-Related Protein 5²
HARL2754²		XK-Related Protein 5a²
UNQ2754²		XRG5³
XRG5A²

External Ids:	HGNC: 20782¹	Entrez Gene: 389610²	Ensembl: ENSG00000186530⁷	UniProtKB: Q6UX68³

ORGUL members:
	NONCODE:n377786

Export aliases for XKR5 gene to outside databases

Previous GC identifers: GC08M006659 GC08M006446

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_023736.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the XKR5 gene promoter:
SRF Elk-1 p53 AML1a SRF (504 AA) RREB-1 Arnt c-Ets-1 YY1 HOXA5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XKR5 promoter sequence

Search SABiosciences Chromatin IP Primers for XKR5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKR5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

XKR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XKR5 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M006666: view genomic region (about GC identifiers)

Start:	6,666,038 bp from pter	End:	6,693,166 bp from pter
Size:	27,129 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: XKR5_HUMAN, Q6UX68 (See protein sequence)

Recommended Name: XK-related protein 5

Size: 686 amino acids; 74982 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q5GH74

Alternative splicing: 2 isoforms: Q6UX68-1 Q6UX68-2

Explore the universe of human proteins at neXtProt for XKR5: NX_Q6UX68

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UX68

XKR5 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_997294.3
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

XKR5 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

XKR5 for domains About GeneDecksing

1 InterPro domain/family:

IPR018629 Transport_prot_XK

Graphical View of Domain Structure for InterPro Entry Q6UX68

ProtoNet protein and cluster: Q6UX68

UniProtKB/Swiss-Prot: XKR5_HUMAN, Q6UX68

Similarity: Belongs to the XK family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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2 GenomeRNAi human phenotypes for XKR5:

Increased Hepatitis C virus re

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for XKR5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for XKR5 gene:

NM_207411.4

Unigene Cluster for XKR5:

XK, Kell blood group complex subunit-related family, member 5

Hs.558840 [show with all ESTs]

Unigene Representative Sequence: NM_207411

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000405979(lincRNA) ENST00000518724(lincRNA)(uc022aqv.1 uc003wqq.3) ENST00000430797(lincRNA)

ENST00000409172(lincRNA)

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Additional cDNA sequence:

AY358489.1 AY534242.1 AY534243.1

4 DOTS entries:

DT.101959721 DT.91692403 DT.91874277 DT.91791975

6 AceView cDNA sequences:

CR604676 AY358489 NM_207411 AL521638 AL521639 BX368984

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for XKR5 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10
SP1:																	-				-
SP2:							-										-				-
SP3:

ECgene alternative splicing isoforms for XKR5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

XKR5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCCAGAAA

About this image

XKR5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

SOURCE GeneReport for Unigene cluster: Hs.558840

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for XKR5 gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Xkr5^{1 , 5}	X Kell blood group precursor-related family, member more^{1, 5}	74.74(n)¹ 66.57(a)¹	8 (10.33 cM)⁵ 319581¹ NM_001113350.1¹ NP_001106821.1¹ 18932729⁵
chicken (Gallus gallus)	Aves	LOC422039¹	XK-related protein 5-like	56.44(n) 45.44(a)	422039 XM_003641074.1 XP_003641122.1
zebrafish (Danio rerio)	Actinopterygii	xrg5¹	XK-related protein 5	49.1(n) 41.47(a)	497102 NM_001012260.1 NP_001012260.1

ENSEMBL Gene Tree for XKR5 (if available)
TreeFam Gene Tree for XKR5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79134989^1,2	F,	--	6471738(+)	`CAGGCA/TTTCAC`	1	--	int¹		3		WA NA EA	358
rs75503828^1,2	F,	--	6472389(+)	`AGCTGG/CAGGGC`	1	--	int¹		1		WA	118
rs111884403^1,2		--	6472407(+)	`GACACG/CTGGGG`	1	--	int¹		1		CSA	2
rs11989622^1,2	C,H,	--	6472534(+)	`TGCGGG/AGACGC`	1	--	int¹		2		CSA WA	120
rs73186388^1,2		--	6472574(+)	`GCGTTC/TCCAGG`	1	--	int¹		0	--	--	--	--
rs9773858^1,2	C,	--	6472644(+)	`CGGAAG/TTGGGC`	1	--	int¹		0	--	--	--	--
rs11137072^1,2		--	6472745(+)	`GCTCTA/GGGTTC`	1	--	int¹		0	--	--	--	--
rs2978898^1,2	C,F,H,	--	6472771(-)	`CTTCGG/AGGCCA`	1	--	int¹		9		WA NA CSA EA	369
rs79981623^1,2	C,	--	6473351(+)	`TCACGC/TGCGCT`	2	A	syn¹		0	--	--	--	--
rs73513743^1,2	C,	--	6473509(+)	`TTTCTG/AGCTAA`	1	--	ut5¹		2		WA	120

HapMap Linkage Disequilibrium report for XKR5 (6666038 - 6693166 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for XKR5
2 CNVs: 5250 8592

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for XKR5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with XKR5)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 389610	HGNC: 20782	AceView: UNQ2754	Ensembl:ENSG00000186530	euGenes: HUgn389610
ECgene: XKR5	H-InvDB: XKR5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for XKR5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for XKR5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for XKR5 gene:
Search GeneIP for patents involving XKR5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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XKR5 Gene

XK, Kell blood group complex subunit-related family, member...

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for XKR5 gene

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for XKR5 gene

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XKR5 Gene

XK, Kell blood group complex subunit-related family, member...

Aliasesfor XKR5 gene

Summariesfor XKR5 gene

Genomic Viewsfor XKR5 gene

Proteinsfor XKR5 gene

Protein Domains /Familiesfor XKR5 gene

Functionfor XKR5 gene

Pathways & Interactionsfor XKR5 gene

Drugs & Compoundsfor XKR5 gene

Transcriptsfor XKR5 gene

Expression for XKR5 gene

Orthologsfor XKR5 gene

Paralogsfor XKR5 gene

Genomic Variantsfor XKR5 gene

Disorders / Diseasesfor XKR5 gene

Publicationsfor XKR5 gene

External Searches for XKR5 gene

Genome Databases showing XKR5 gene

Other Databases showing XKR5 gene

Specialized Databases showing XKR5 gene

Intellectual Propertyfor XKR5 gene

Productsfor XKR5 gene

View Random Gene

Aliases
for XKR5 gene

Summaries
for XKR5 gene

Genomic Views
for XKR5 gene

Proteins
for XKR5 gene

Protein Domains /
Families
for XKR5 gene

Function
for XKR5 gene

Pathways & Interactions
for XKR5 gene

Drugs & Compounds
for XKR5 gene

Transcripts
for XKR5 gene

Expression
for XKR5 gene

Orthologs
for XKR5 gene

Paralogs
for XKR5 gene

Genomic Variants
for XKR5 gene

Disorders / Diseases
for XKR5 gene

Publications
for XKR5 gene

Intellectual Property
for XKR5 gene

Products
for XKR5 gene