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Aliases for XKR5 Gene

Aliases for XKR5 Gene

  • XK, Kell Blood Group Complex Subunit-Related Family, Member 5 2 3
  • X Kell Blood Group Precursor-Related Family, Member 5 2 3
  • XK-Related Protein 5a 3
  • XK-Related Protein 5 3
  • HARL2754 3
  • UNQ2754 3
  • XRG5BM 3
  • XRG5A 3
  • XRG5 4

External Ids for XKR5 Gene

Previous GeneCards Identifiers for XKR5 Gene

  • GC08M006659
  • GC08M006446
  • GC08M006666

Summaries for XKR5 Gene

GeneCards Summary for XKR5 Gene

XKR5 (XK, Kell Blood Group Complex Subunit-Related Family, Member 5) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR5 Gene

Genomics for XKR5 Gene

Regulatory Elements for XKR5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for XKR5 Gene

6,808,517 bp from pter
6,835,644 bp from pter
27,128 bases
Minus strand

Genomic View for XKR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XKR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR5 Gene

Proteins for XKR5 Gene

  • Protein details for XKR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    XK-related protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5GH74

    Protein attributes for XKR5 Gene

    686 amino acids
    Molecular mass:
    74982 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for XKR5 Gene


neXtProt entry for XKR5 Gene

Proteomics data for XKR5 Gene at MOPED

Post-translational modifications for XKR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKR5 Gene

Domains for XKR5 Gene

Protein Domains for XKR5 Gene


Suggested Antigen Peptide Sequences for XKR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6UX68
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR5: view

No data available for Gene Families for XKR5 Gene

Function for XKR5 Gene

Phenotypes for XKR5 Gene

genes like me logo Genes that share phenotypes with XKR5: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XKR5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XKR5 Gene

Localization for XKR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for XKR5 Gene COMPARTMENTS Subcellular localization image for XKR5 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for XKR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR5: view

Pathways for XKR5 Gene

SuperPathways for XKR5 Gene

No Data Available

Interacting Proteins for XKR5 Gene

Gene Ontology (GO) - Biological Process for XKR5 Gene


No data available for Pathways by source for XKR5 Gene

Transcripts for XKR5 Gene

mRNA/cDNA for XKR5 Gene

(3) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR5 Gene

XK, Kell blood group complex subunit-related family, member 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XKR5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKR5 Gene

No ASD Table

Relevant External Links for XKR5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XKR5 Gene

mRNA expression in normal human tissues for XKR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XKR5 Gene

This gene is overexpressed in Cervix - Endocervix (17.5), Uterus (5.7), Prostate (5.4), and Cervix - Ectocervix (4.8).

SOURCE GeneReport for Unigene cluster for XKR5 Gene Hs.558840

genes like me logo Genes that share expressions with XKR5: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for XKR5 Gene

Orthologs for XKR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XKR5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia XKR5 35
  • 72.05 (n)
  • 65.05 (a)
(Canis familiaris)
Mammalia XKR5 35
  • 73.37 (n)
  • 63.37 (a)
(Mus musculus)
Mammalia Xkr5 35
  • 74.79 (n)
  • 66.57 (a)
Xkr5 16
(Pan troglodytes)
Mammalia XKR5 35
  • 98.54 (n)
  • 97.23 (a)
(Rattus norvegicus)
Mammalia Xkr5 35
  • 73.06 (n)
  • 63.04 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia xkr5 35
  • 53.61 (n)
  • 45.63 (a)
(Danio rerio)
Actinopterygii xrg5 35
  • 49.68 (n)
  • 42.64 (a)
Species with no ortholog for XKR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XKR5 Gene

Gene Tree for XKR5 (if available)
Gene Tree for XKR5 (if available)

Paralogs for XKR5 Gene

No data available for Paralogs for XKR5 Gene

Variants for XKR5 Gene

Sequence variations from dbSNP and Humsavar for XKR5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs385860 -- 6,808,255(+) GTCTG(A/G)AGCCC intron-variant, downstream-variant-500B
rs2004156 -- 6,809,974(-) GCACC(A/G)TGCCT utr-variant-3-prime
rs2377017 -- 6,810,055(-) gctca(C/T)tgcag utr-variant-3-prime
rs2553718 -- 6,812,383(+) GAAGT(C/T)TGCAT intron-variant
rs2553719 -- 6,814,145(+) GCAGC(A/G)CGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XKR5 Gene

Variant ID Type Subtype PubMed ID
esv2422383 CNV Duplication 17116639
nsv831220 CNV Gain 17160897
nsv465436 CNV Gain 19166990
esv2752262 CNV Gain 17911159
nsv465437 CNV Gain 19166990
nsv890060 CNV Loss 21882294

Relevant External Links for XKR5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR5 Gene

Disorders for XKR5 Gene

No disorders were found for XKR5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for XKR5 Gene

Publications for XKR5 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for XKR5 Gene

Sources for XKR5 Gene

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