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XKR4 Gene

protein-coding GIFtS: 44

GC08P056178

XK, Kell blood group complex subunit-related family, member 4
(Previous names: X Kell blood group precursor-related family, member 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
KIAA1889 ^¹, ², ³
XRG4 ^², ³

Descriptions
X Kell blood group precursor-related family, member 4 ^¹, ²
XK, Kell blood group complex subunit-related family, member 4 ^²

External Ids
HGNC: 29394¹
Entrez Gene: 114786²
UniProtKB: Q5GH76³
Ensembl: ENSG00000206579⁷

Search outside databases for aliases for XKR4 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XKR4 gene

Entrez Gene cytogenetic band: 8q12.1 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12.1

XKR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P056178: (about GC identifiers)

Start:	56,177,571 bp from pter
End:	56,601,268 bp from pter
Size:	423,698 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XKR4_HUMAN, Q5GH76 (See protein sequence)

Recommended Name: XK-related protein 4

Size: 650 amino acids; 71501 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q96PZ8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_443130.1

ENSEMBL proteins:

ENSP00000328326

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for XKR4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XKR4
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for XKR4

Assays for XKR4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q5GH76

ProtoNet protein and cluster: Q5GH76

UniProtKB/Swiss-Prot: XKR4_HUMAN, Q5GH76

Similarity: Belongs to the XK family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_056298

Applied Biosystems Silencer® siRNAs for XKR4

Sigma-Aldrich siRNA for XKR4

Sigma-Aldrich shRNA for XKR4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_052898
Myc/DDK tagged cDNA clone in CMV expression vector: NM_052898
untagged cDNA clone in CMV expression vector: NM_052898

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_052898

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XKR4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_056298

Sigma-Aldrich siRNA for XKR4

Sigma-Aldrich shRNA for XKR4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_052898

REFSEQ mRNAs for XKR4 gene:

NM_052898.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_052898

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_052898
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_052898
                                 untagged cDNA clone in CMV expression vector: NM_052898

Additional cDNA sequence:

AB067476.1 AY534241.1

2 DOTS entries:

DT.311757 DT.120643732

21 AceView cDNA sequences:

BX952967 CA390886 AB067476 BQ881619 BI820247 AU252430 AU252431 AI879399

D60966 D60471 R37600 BM449480 D61255 D61083 D80844 R54211

R15224 R54212 R43150 R17904 T79882

highest scoring ESTs for XKR4:

AB067476 AI879399 AU252431 BI820247 BM449480 BX105819 CA390886 D60471 D60966 D61083

Unigene Cluster for XKR4:

XK, Kell blood group complex subunit-related family, member 4

Hs.130197 [show with all ESTs]

Unigene Representative Sequence: AY534241

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000327381

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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XKR4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XKR4

¹ / ² / ³

3 probe-sets matching XKR4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76777_s_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	R54212	0.80	1.00	0.91	1
237802_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R54212	0.80	1.00	0.91	1
237802_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCTTTTCG

SOURCE GeneReport for Unigene cluster: Hs.130197

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XKR4 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XKR4¹	--	XK, Kell blood group complex subunit-related family, more	93.73(n) 96.75(a)	609128 XM_846336.1 XP_851429.1
chimpanzee (Pan troglodytes)	XKR4¹	--	XK, Kell blood group complex subunit-related family, more	99.54(n) 99.54(a)	613217 NM_001033036.1 NP_001028208.1
rat (Rattus norvegicus)	Xkr4¹	--	XK, Kell blood group complex subunit-related family, more	90.73(n) 95.95(a)	297801 NM_001011971.1 NP_001011971.1
mouse (Mus musculus)	Xkr4^{1, 5}	1⁵	X Kell blood group precursor related family member more^{1, 5}	91.55(n)¹ 95.98(a)¹	497097¹ NM_001011874.1¹ NP_001011874.1¹ AK135172⁵ AK220428⁵ (see all 8)
zebrafish (Danio rerio)	id:ibd5007¹	--	id:ibd5007	73.76(n) 80.53(a)	338243 NM_001012258.1 NP_001012258.1

About this table Species with no ortholog for XKR4

ENSEMBL Gene Tree for XKR4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XKR4 gene

XKR6² XKR7² XKR5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2425 NCBI SNPs in XKR4 are shown (see all 2425 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 865)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7827845^1,2	C,F,H	56601376(+)	`AGACTG/CTGTCC`	1	--	ng3¹		15	EU EA WA NA	1398
	rs16921969^1,2	C,F,H	56601712(+)	`CTTCAT/CTGTTT`	1	--	ng3¹		11	NA EU EA WA	982
	rs2622543^1,2	A,C,F,H,O	56470201(-)	`AGAGGG/TCTCAT`	1	--	int¹		16	NS NA EU EA WA	1086
--	rs2929050^1,2	A,C,F,H,O	56526733(-)	`GCTACC/GGCCAG`	1	--	int¹		4	WA NA	258
	rs2658917^1,2	A,C,F,H,O	56510052(-)	`AAGGAA/GTTGCA`	1	--	int¹		8	EA NA EU WA	628
	rs2939675^1,2	A,C,F,H,O	56573336(+)	`CGCTGC/TGCCCT`	1	--	int¹		7	EU EA WA NA	558
	rs997854^1,2	A,C,F,H,O	56222579(-)	`AAGGCA/GTAATT`	1	--	int¹		15	NA EA NS EU WA	914
	rs2061998^1,2	A,C,F,H,O	56186323(-)	`TGGGCT/CGTATG`	1	--	int¹		4	EU EA WA	418
	rs2622575^1,2	A,C,F,H,O	56571623(-)	`ATGCCC/TTAATT`	1	--	int¹		6	EU EA NA	440
	rs2036619^1,2	A,C,F,H,O	56420800(-)	`TGTTAC/TGAACA`	1	--	int¹		8	EA NA EU WA	628

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HapMap Linkage Disequilibrium images for XKR4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: XKR4 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for XKR4 gene:

Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)^{3, 4} Nagase T....Ohara O. (2001)
Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PubMed id 18521090)³ Lavedan C....Polymeropoulos M.H. (2008)
Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)⁴ Imami K.... Ishihama Y. (2008)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 114786	HGNC: 29394	AceView: KIAA1889	Ensembl:ENSG00000206579	euGenes: HUgn114786
ECgene: XKR4	H-InvDB: XKR4

(According to HUGE)
About This Section

HUGE: KIAA1889

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for XKR4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for XKR4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XKR4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XKR4		Antibodies for XKR4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XKR4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for XKR4

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XKR4 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for XKR4

Summaries
for XKR4

Genomic Location
for XKR4

Proteins
for XKR4

Protein Domains/
Families
for XKR4

Gene Function
for XKR4

Pathways & Interactions
for XKR4

Drugs & Compounds
for XKR4

Transcripts
for XKR4

Expression
for XKR4

Orthologs
for XKR4

Paralogs
for XKR4

SNPs/Variants
for XKR4

Disorders & Mutations
for XKR4

Medical News
for XKR4

Publications
for XKR4

Search for XKR4

Genome Databases showing XKR4

Other Databases showing XKR4

Specialized Databases showing XKR4

Licensable Technologies
for XKR4

Services
for XKR4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XKR4 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor XKR4

Summariesfor XKR4

Genomic Locationfor XKR4

Proteinsfor XKR4

Protein Domains/Familiesfor XKR4

Gene Functionfor XKR4

Pathways & Interactionsfor XKR4

Drugs & Compoundsfor XKR4

Transcriptsfor XKR4

Expression for XKR4

Orthologsfor XKR4

Paralogsfor XKR4

SNPs/Variantsfor XKR4

Disorders & Mutationsfor XKR4

Medical Newsfor XKR4

Publicationsfor XKR4

Search for XKR4

Genome Databases showing XKR4

Other Databases showing XKR4

Specialized Databases showing XKR4

Licensable Technologiesfor XKR4

Servicesfor XKR4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XKR4

Summaries
for XKR4

Genomic Location
for XKR4

Proteins
for XKR4

Protein Domains/
Families
for XKR4

Gene Function
for XKR4

Pathways & Interactions
for XKR4

Drugs & Compounds
for XKR4

Transcripts
for XKR4

Expression
for XKR4

Orthologs
for XKR4

Paralogs
for XKR4

SNPs/Variants
for XKR4

Disorders & Mutations
for XKR4

Medical News
for XKR4

Publications
for XKR4

Licensable Technologies
for XKR4

Services
for XKR4