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XKR4 Gene

protein-coding   GIFtS: 48
GCID: GC08P056015

XK, Kell Blood Group Complex Subunit-Related Family, Member...

(Previous names: X Kell blood group precursor-related family, member 4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
XK, Kell Blood Group Complex Subunit-Related Family, Member 41 2
X Kell Blood Group Precursor-Related Family, Member 41 2
XRG42 3
XK-Related Protein 42
KIAA18893

External Ids:    HGNC: 293941   Entrez Gene: 1147862   Ensembl: ENSG000002065797   UniProtKB: Q5GH763   

Export aliases for XKR4 gene to outside databases

Previous GC identifers: GC08P056178 GC08P051483


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for XKR4 Gene:
XKR4 (XK, Kell blood group complex subunit-related family, member 4) is a protein-coding gene. An important paralog of this gene is XKR6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the XKR4 gene promoter:
         LHX3b/Lhx3b   Nkx2-2   MEF-2   NRSF form 1   Nkx2-5   NRSF form 2   Evi-1   AREB6   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXKR4 promoter sequence
   Search Chromatin IP Primers for XKR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XKR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.1   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.1

XKR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XKR4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P056015:  view genomic region     (about GC identifiers)

Start:
56,014,949 bp from pter      End:
56,454,613 bp from pter
Size:
439,665 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XKR4_HUMAN, Q5GH76 (See protein sequence)
Recommended Name: XK-related protein 4  
Size: 650 amino acids; 71501 Da
Secondary accessions: Q96PZ8

Explore the universe of human proteins at neXtProt for XKR4: NX_Q5GH76

Explore proteomics data for XKR4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See XKR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443130.1  
    ENSEMBL proteins: 
     ENSP00000328326  

    XKR4 Human Recombinant Protein Products:

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    antibodies-online peptides for XKR4

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    antibodies-online antibodies for XKR4 (11 products) 

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    antibodies-online kits for XKR4 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018629 Transport_prot_XK

    Graphical View of Domain Structure for InterPro Entry Q5GH76

    ProtoNet protein and cluster: Q5GH76

    UniProtKB/Swiss-Prot: XKR4_HUMAN, Q5GH76
    Similarity: Belongs to the XK family


    Find genes that share domains with XKR4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for XKR4:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for XKR4

    miRNA
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    miRTarBase miRNAs that target XKR4:
    hsa-mir-335-5p (MIRT017434)

    Block miRNA regulation of human, mouse, rat XKR4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate XKR4 (see all 17):
    hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-1271 hsa-miR-3167 hsa-miR-15b* hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidXKR4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat XKR4

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    GenScript: all cDNA clones in your preferred vector: XKR4 (NM_052898)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XKR4_HUMAN, Q5GH76: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with XKR4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XKR4
    Interactions:

        Search GeneGlobe Interaction Network for XKR4

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XKR4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XKR4 gene: 
    NM_052898.1  

    Unigene Cluster for XKR4:

    XK, Kell blood group complex subunit-related family, member 4
    Hs.130197  [show with all ESTs]
    Unigene Representative Sequence: AY534241
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327381(uc003xsf.3) ENST00000518261
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate XKR4 (see all 17):
    hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-1271 hsa-miR-3167 hsa-miR-15b* hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidXKR4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat XKR4
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    GenScript: all cDNA clones in your preferred vector: XKR4 (NM_052898)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for XKR4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XKR4
      QuantiTect SYBR Green Assays in human, mouse, rat XKR4
      QuantiFast Probe-based Assays in human, mouse, rat XKR4

    Additional mRNA sequence: 

    AB067476.1 AY534241.1 

    2 DOTS entries:

    DT.311757  DT.120643732 

    21 AceView cDNA sequences:

    AB067476 BX952967 CA390886 BQ881619 BI820247 AU252431 AI879399 AU252430 
    D60966 D60471 BM449480 R37600 D61255 D61083 D80844 R54211 
    R15224 R54212 R43150 R17904 T79882 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XKR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTTTTCG
    XKR4 Expression
    About this image


    XKR4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
    XKR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XKR4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130197
        Custom PCR Arrays for XKR4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for XKR4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xkr41 , 5 X Kell blood group precursor related family member more1, 5 90.93(n)1
    94.9(a)1
      1 (1.60 cM)5
    4970971  NM_001011874.11  NP_001011874.11 
     32059015 
    chicken
    (Gallus gallus)
    Aves LOC1008581711 XK-related protein 4-like 84.18(n)
    90.04(a)
      100858171  XM_004939964.1  XP_004940021.1 
    lizard
    (Anolis carolinensis)
    Reptilia XKR46
    XK, Kell blood group complex subunit-related famil...
    95(a)
    1 ↔ 1
    GL343244.1(575214-616060)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia xkr41 XK, Kell blood group complex subunit-related family, more 77.78(n)
    85.04(a)
      613062  NM_001032307.1  NP_001027478.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1230351 zgc:123035 73.38(n)
    80.03(a)
      777704  NM_001012258.1  NP_001012258.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG325796
    --
    20(a)
    1 → many
    X(16217319-16219801)
    worm
    (Caenorhabditis elegans)
    Secernentea ced-86
    Protein CED-8 (ced-8) mRNA, complete cds
    22(a)
    1 → many
    X(8414015-8416919) WBGene00000422


    ENSEMBL Gene Tree for XKR4 (if available)
    TreeFam Gene Tree for XKR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for XKR4 gene
    XKR62  XKR82  XKR72  XKR92  
    2 SIMAP similar genes for XKR4 using alignment to 1 protein entry:     XKR4_HUMAN:
    XKR6    XKR7

    Find genes that share paralogs with XKR4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for XKR4 (see all 8778)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433444471,2
    --56013044(+) CCAGTA/CTGTGA 1 -- us2k10--------
    rs1509037901,2
    --56013147(+) GAGGCA/GGCTCT 1 -- us2k10--------
    rs749524591,2
    F--56013226(+) TAGTTC/TGAACT 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1393784531,2
    --56013396(+) TCTCTA/GTTTCT 1 -- us2k10--------
    rs1500245431,2
    C--56013401(+) ATTTCC/TTACAT 1 -- us2k10--------
    rs1455135231,2
    --56013477(+) TTTTAG/TTGAGG 1 -- us2k10--------
    rs1391672211,2
    --56013490(+) TTAAAA/CATCTC 1 -- us2k10--------
    rs1440349161,2
    --56013526(+) CTCCTC/TGAATC 1 -- us2k10--------
    rs1906772331,2
    --56013657(+) GGTGGC/TGCCTG 1 -- us2k10--------
    rs1464319101,2
    C--56013667(+) GCTCCC/G/TGGCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for XKR4 (56014949 - 56264949 bp, first 250kb of XKR4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for XKR4 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2575236CNV Deletion19546169
    esv5044CNV Deletion18987735
    esv2060022CNV Deletion18987734
    esv4576CNV Deletion18987735
    esv2677140CNV Deletion23128226
    esv2663524CNV Deletion23128226
    esv2737013CNV Deletion23290073
    esv2737012CNV Deletion23290073
    dgv1287e199CNV Deletion23128226
    esv1133504CNV Deletion17803354

    Human Gene Mutation Database (HGMD): XKR4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XKR4
    DNA2.0 Custom Variant and Variant Library Synthesis for XKR4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with XKR4           About GenesLikeMe

    Genetic Association Database (GAD): XKR4
    Human Genome Epidemiology (HuGE) Navigator: XKR4 (4 documents)

    Export disorders for XKR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XKR4 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with XKR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PubMed id 18521090)1, 4, 9 Lavedan C....Polymeropoulos M.H. (Mol. Psychiatry 2009)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. (PubMed id 19573479)1, 4 Volpi S....Lavedan C. (J Clin Psychiatry 2009)
    4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    5. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    6. Analysis of GWAS top hits in ADHD suggests association to two polymorphisms located in genes expressed in the cerebellum. (PubMed id 20607790)1 Lantieri F....Devoto M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    8. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)4 O'Donnell C.J....Demissie S. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114786 HGNC: 29394 AceView: KIAA1889 Ensembl:ENSG00000206579 euGenes: HUgn114786
    ECgene: XKR4 H-InvDB: XKR4

    (According to HUGE)
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    HUGE: KIAA1889

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for XKR4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for XKR4 gene:
    Search GeneIP for patents involving XKR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     OriGene Antibodies for XKR4   OriGene RNAi products in human, mouse, rat for XKR4  
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     Block miRNA regulation of human, mouse, rat XKR4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing XKR4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XKR4 Predesigned siRNA for gene silencing in human, mouse, rat XKR4
     QuantiFast Probe-based Assays in human, mouse, rat XKR4 QuantiTect SYBR Green Assays in human, mouse, rat XKR4
     Custom PCR Arrays for XKR4 Search Chromatin IP Primers for XKR4
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     SwitchGear 3'UTR luciferase reporter plasmids for XKR4
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     genOway: Develop your customized and physiologically relevant rodent model for XKR4
     antibodies-online antibodies for XKR4 (11 products)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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