XKR4 Gene
protein-coding GIFtS: 46
GCID: GC08P056015
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XK, Kell blood group complex subunit-related family, member...(Previous names: X Kell blood group precursor-related family, member 4 )
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Aliases
for XKR4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| XK, Kell Blood Group Complex Subunit-Related Family, Member 41 2 | | X Kell Blood Group Precursor-Related Family, Member 41 2 | | KIAA18891 3 | | XRG42 3 | | XK-Related Protein 42 |
Export aliases for XKR4 gene to outside databasesPrevious GC identifers: GC08P056178 GC08P051483 |
Summaries
for XKR4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for XKR4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XKR4 gene promoter:
LHX3b/Lhx3b Nkx2-2 MEF-2 NRSF form 1 Nkx2-5 NRSF form 2 Evi-1 AREB6 MEF-2A aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for XKR4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKR4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q12.1 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12.1XKR4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P056015: view genomic region
(about GC identifiers)
Start:
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56,014,949 bp from pter |
End:
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56,438,714 bp from pter |
Size:
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423,766 bases |
Orientation:
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plus strand |
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Proteins
for XKR4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XKR4_HUMAN, Q5GH76 (See
protein sequence)Recommended Name: XK-related protein 4 Size: 650 amino acids; 71501 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q96PZ8Explore the universe of human proteins at neXtProt for XKR4: NX_Q5GH76
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5GH76
XKR4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443130.1
ENSEMBL proteins: ENSP00000328326
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
XKR4 for ontologies About GeneDecksing
XKR4 Antibody Products:
Assay Products for XKR4: |
Protein
Domains /
Families
for XKR4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XKR4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5GH76ProtoNet protein and cluster: Q5GH76 UniProtKB/Swiss-Prot: XKR4_HUMAN, Q5GH76Similarity: Belongs to the XK family |
Function
for XKR4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XKR4 (NM_052898) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKR4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR4 |
2 GenomeRNAi human phenotypes for XKR4:
|
Pathways & Interactions
for XKR4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XKR4
|
Drugs & Compounds
for XKR4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XKR4
Search CenterWatch for drugs/clinical trials and news about XKR4
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Transcripts
for XKR4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XKR4 gene: NM_052898.1 Unigene Cluster for XKR4: XK, Kell blood group complex subunit-related family, member 4 Hs.130197 [show with all ESTs]Unigene Representative Sequence: AY5342411 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000327381(uc003xsf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XKR4 (NM_052898) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKR4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR4 |
Additional cDNA sequence: AB067476.1 AY534241.1 2 DOTS entries: DT.311757 DT.120643732 21 AceView cDNA sequences: BX952967 CA390886 BQ881619 AB067476 AU252430 AU252431 BI820247 AI879399 BM449480 D60471 D60966 R37600 D61255 D61083 R54211 D80844 R15224 R54212 R43150 T79882 R17904
GeneLoc Exon Structure
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Expression
for XKR4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XKR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCTTTTCG
About this image
See XKR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XKR4
SOURCE GeneReport for Unigene cluster: Hs.130197
SABiosciences Custom PCR Arrays for XKR4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKR4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XKR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKR4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR4 |
Orthologs
for XKR4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for XKR4 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
XKR46 |
Uncharacterized protein |
84(a) |
1 ↔ 1 |
2(114373278-114615787) |
lizard
(Anolis carolinensis) |
Reptilia |
XKR46 |
-- |
94(a) |
1 ↔ 1 |
GL343244.1(575214-616060) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1230351 |
zgc:123035 |
73.76(n)
80.53(a) |
|
777704 NM_001012258.1 NP_001012258.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG325796 |
-- |
19(a) |
possible ortholog |
X(16217319-16219801) |
worm
(Caenorhabditis elegans) |
Secernentea |
ced-86 |
Cell death abnormality protein 8 |
22(a) |
possible ortholog |
X(8413962-8416866) |
ENSEMBL Gene Tree for XKR4 (if available)
TreeFam Gene Tree for XKR4 (if available) |
Paralogs
for XKR4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XKR4 gene
- XKR82 XKR62 XKR72 XKR92
2 SIMAP similar genes for XKR4 using alignment to 1 protein entry: XKR4_HUMAN:XKR6 XKR7
XKR4 for paralogs About GeneDecksing
|
Genomic Variants
for XKR4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XKR4 (56014949 - 56264949 bp, first 250kb of XKR4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for XKR4
5 CNVs: 95443 52583 100352 52584 33040
8 Indels: 47555 41087 42171 28944 28945 62814 42386 13058
Human Gene Mutation Database (HGMD): XKR4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XKR4 |
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Disorders
/ Diseases
for XKR4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XKR4 for disorders About GeneDecksing
2  diseases for XKR4: About MalaCardsadhd schizophrenia
Human Genome Epidemiology (HuGE) Navigator: XKR4 (4 documents)
Export disorders for XKR4 gene to outside databases
|
Publications
for XKR4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XKR4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with XKR4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T....Ohara O. (2001)
- Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PubMed id 18521090)1, 9 Lavedan C....Polymeropoulos M.H. (2008)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Analysis of GWAS top hits in ADHD suggests associatio n to two polymorphisms located in genes expressed in the cerebellum. (PubMed id 20607790)1 Lantieri F....Devoto M. (2010)
- Applicability of a genetic signature for enhanced ilo peridone efficacy in the treatment of schizophrenia. (PubMed id 19573479)1 Volpi S....Lavedan C. (2009)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for XKR4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing XKR4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XKR4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing XKR4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for XKR4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for XKR4 gene:
Search GeneIP for patents involving XKR4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XKR4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XKR4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XKR4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKR4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XKR4 | | OriGene 3'-UTR Clone for XKR4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XKR4 | | OriGene Custom Protein Services for XKR4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XKR4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XKR4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKR4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XKR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKR4 |
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| | | | Search Tocris compounds for XKR4 |
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 | | | XKR4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR4 |
|  |  |  | | | | Search ThermoFisher Antibodies for XKR4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR4 |
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