XKR3 Gene
protein-coding GIFtS: 40
GCID: GC22M017264
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XK, Kell blood group complex subunit-related family, member...(Previous names: X Kell blood group precursor-related family, member 3 )
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Aliases
for XKR3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| XK, Kell Blood Group Complex Subunit-Related Family, Member 31 2 | | X Kell Blood Group-Related 32 3 | | XTES1 2 3 5 | | MGC572111 | | XRG32 3 5 | | Expressed In Testis2 | | X Kell Blood Group Precursor-Related Family, Member 31 2 | | XK-Related Protein 32 |
Export aliases for XKR3 gene to outside databasesPrevious GC identifers: GC22M015639 GC22M001083 |
Summaries
for XKR3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XKR3:
XKRX (MIM 300684) and XKR3 are homologs of the Kell blood group precursor XK (MIM 314850), which is a putative membranetransporter and a component of the XK/Kell complex of the Kell blood group system (Calenda et al., 2006 (PubMed16431037)).(supplied by OMIM, Mar 2008)
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Genomic Views
for XKR3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011519.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XKR3 gene promoter:
TBP AML1a FOXJ2 (long isoform) Cart-1 Nkx2-5 FOXJ2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for XKR3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XKR3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.1 Ensembl cytogenetic band: 22q11.1 HGNC cytogenetic band: 22q11.1XKR3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M017264: view genomic region
(about GC identifiers)
Start:
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17,264,302 bp from pter |
End:
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17,302,589 bp from pter |
Size:
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38,288 bases |
Orientation:
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minus strand |
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Proteins
for XKR3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XKR3_HUMAN, Q5GH77 (See
protein sequence)Recommended Name: XK-related protein 3 Size: 459 amino acids; 53448 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RPN1 Q52PG8 Q8N7E1Explore the universe of human proteins at neXtProt for XKR3: NX_Q5GH77
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5GH77
XKR3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_787074.2
ENSEMBL proteins: ENSP00000331704
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
XKR3 for ontologies About GeneDecksing
XKR3 Antibody Products:
Assay Products for XKR3: |
Protein
Domains /
Families
for XKR3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XKR3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5GH77ProtoNet protein and cluster: Q5GH77 UniProtKB/Swiss-Prot: XKR3_HUMAN, Q5GH77Similarity: Belongs to the XK family |
Function
for XKR3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for XKR3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR3 |
1 GenomeRNAi human phenotype for XKR3:
|
Pathways & Interactions
for XKR3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XKR3
|
Drugs & Compounds
for XKR3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XKR3
Search CenterWatch for drugs/clinical trials and news about XKR3
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Transcripts
for XKR3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XKR3 gene: NM_175878.3 Unigene Cluster for XKR3: XK, Kell blood group complex subunit-related family, member 3 Hs.356069 [show with all ESTs]Unigene Representative Sequence: NM_1758781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000331428(uc002zlv.3 uc011agf.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XKR3 (NM_175878) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XKR3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XKR3 |
Additional cDNA sequence: AK098608.1 AY534240.1 AY989815.3 BC045548.1 BC137521.1 BC137522.1 BC144679.1 2 DOTS entries: DT.120651461 DT.95095094 7 AceView cDNA sequences: BI463670 BX282682 AK098608 BC045548 NM_175878 BI827782 BU584713
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for XKR3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for XKR3
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Expression
for XKR3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XKR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCATAAAAT
About this image
See XKR3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.356069
UniProtKB/Swiss-Prot: XKR3_HUMAN, Q5GH77Tissue specificity: Expressed predominantly, if not exclusively, in testis
SABiosciences Custom PCR Arrays for XKR3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKR3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat XKR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XKR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XKR3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR3 |
Orthologs
for XKR3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for XKR3 gene from 2/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
XKRX6 |
Uncharacterized protein |
39(a) |
1 → many |
4(5160873-5164100) |
zebrafish
(Danio rerio) |
Actinopterygii |
xkrx6 |
XK, Kell blood group complex subunit-related, X-li... |
33(a) |
1 → many |
14(42794053-42816321) |
ENSEMBL Gene Tree for XKR3 (if available)
TreeFam Gene Tree for XKR3 (if available) |
Paralogs
for XKR3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XKR3 gene
- XK2 XKRX2
4 SIMAP similar genes for XKR3 using alignment to 2 protein entries: XKR3_HUMAN (see all proteins):XKRY2 XKRX XK XKRY
XKR3 for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for XKR3 (see all 8)
PGOHUM00000233761 PGOHUM00000233781 PGOHUM00000233828 PGOHUM00000233833 PGOHUM00000233982
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Genomic Variants
for XKR3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XKR3 (17264302 - 17302589 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for XKR3
7 CNVs: 50793 29714 4115 53817 34559 8898 50794 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XKR3 |
|
Disorders
/ Diseases
for XKR3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 XKR3 for disorders About MalaCards
XKR3 for disorders About GeneDecksing
OMIM gene information: 611674
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: XKR3 (1 document)
Export disorders for XKR3 gene to outside databases
|
Publications
for XKR3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XKR3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with XKR3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of two new members, XPLAC and XTES, of the XK family. (PubMed id 16431037)1, 2, 3 Calenda G.... Lee S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Robust, high-throughput solution for blood group geno typing. (PubMed id 20560530)1 Le Goff G.C....Marquette C.A. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for XKR3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing XKR3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XKR3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XKR3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for XKR3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for XKR3 gene:
Search GeneIP for patents involving XKR3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XKR3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XKR3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XKR3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XKR3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XKR3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XKR3 |
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