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XKR3 Gene

protein-coding GIFtS: 38

GC22M015639

XK, Kell blood group complex subunit-related family, member 3
(Previous names: X Kell blood group precursor-related family, member 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC57211 ^¹, ²
XRG3 ^², ³, ⁵
XTES ^¹, ², ³, ⁵

Descriptions
X Kell blood group precursor-related family, member 3 ^¹, ²
X Kell blood group-related 3 ^³
XK, Kell blood group complex subunit-related family, member 3 ^²
expressed in testis ^²

External Ids
HGNC: 28778¹
Entrez Gene: 150165²
UniProtKB: Q5GH77³
Ensembl: ENSG00000172967⁷

Search outside databases for aliases for XKR3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for XKR3:

XKRX (MIM 300684) and XKR3 are homologs of the Kell blood group precursor XK (MIM 314850), which is

a putative membrane transporter and a component of the XK/Kell complex of the Kell blood group

system (Calenda et al., 2006 [PubMed 16431037]).[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XKR3 gene

Entrez Gene cytogenetic band: 22q11.1 Ensembl cytogenetic band: 22q11.1 HGNC cytogenetic band: 22q11.1

XKR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M015639: (about GC identifiers)

Start:	15,644,302 bp from pter
End:	15,682,584 bp from pter
Size:	38,283 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000022.9 NT_011519.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: XKR3_HUMAN, Q5GH77 (See protein sequence)

Recommended Name: XK-related protein 3

Size: 459 amino acids; 53448 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: B2RPN1 Q52PG8 Q8N7E1

REFSEQ proteins: NP_787074.2

ENSEMBL proteins:

ENSP00000331704

Human Recombinant Proteins

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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for XKR3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for XKR3

Assays for XKR3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q5GH77

ProtoNet protein and cluster: Q5GH77

UniProtKB/Swiss-Prot: XKR3_HUMAN, Q5GH77

Similarity: Belongs to the XK family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175878

Applied Biosystems Silencer® siRNAs for XKR3

Sigma-Aldrich siRNA for XKR3

Sigma-Aldrich shRNA for XKR3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_175878
Myc/DDK tagged cDNA clone in CMV expression vector: NM_175878
untagged cDNA clones in CMV expression vector (see all 3): NM_175878

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_175878

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for XKR3 (ENSP00000331704³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KEL	ENSP00000347409³	STRING (score=.89)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XKR3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XKR3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175878

Sigma-Aldrich siRNA for XKR3

Sigma-Aldrich shRNA for XKR3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_175878

REFSEQ mRNAs for XKR3 gene:

NM_175878.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_175878

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_175878
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_175878
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_175878

Additional cDNA sequence:

AK098608.1 AY534240.1 AY989815.3 BC045548.1 BC137521.1 BC137522.1 BC144679.1

2 DOTS entries:

DT.120651461 DT.95095094

7 AceView cDNA sequences:

BC045548 NM_175878 BI463670 BX282682 BI827782 AK098608 BU584713

highest scoring ESTs for XKR3:

AK098608 BC045548 BI463670 BI827782 BX282682 AY534240 AY989815 BU584713 NM_175878 BI463669

Unigene Cluster for XKR3:

XK, Kell blood group complex subunit-related family, member 3

Hs.356069 [show with all ESTs]

Unigene Representative Sequence: NM_175878

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for XKR3

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for XKR3

1 Ensembl transcript including schematic representation:

ENST00000331428

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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XKR3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XKR3

¹ Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: TTCATAAAAT

SOURCE GeneReport for Unigene cluster: Hs.356069
UniProtKB/Swiss-Prot: XKR3_HUMAN, Q5GH77
Tissue specificity: Expressed predominantly, if not exclusively, in testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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ENSEMBL Gene Tree for XKR3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for XKR3 gene

XK² XKRX² XKRY2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/305 NCBI SNPs in XKR3 are shown (see all 305 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 129)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2215842^1,2	A,C,F,H	15683469(+)	`ccataT/Cttgac`	1	--	ng3¹		4	EU EA WA	412
	rs5748622^1,2	A,C,F,H	15644565(+)	`GGAGTT/GACAGT`	1	N/H	mis¹ ese³		11	EU EA WA NA	978
	rs9605146^1,2	A,C,F,H	15645194(+)	`CTATCG/AGCGGT`	1	L/P	mis¹ ese³		12	EU EA WA	1256
	rs175139^1,2	A,C,F,H	15684246(+)	`ATTGAT/CATCAT`	1	--	ng3¹		5	MN EU EA WA	602
	rs2192431^1,2	A,C,F,H	15683596(+)	`AAATAT/GCAACT`	1	--	ng3¹ tfbs³		1	WA	120
	rs5748621^1,2	A,C,F,H	15643854(+)	`caatgG/Cacctt`	1	--	ng5¹		5	EU EA WA	590
	rs175138^1,2	A,C,F,H	15684132(+)	`ACAATA/GATAAC`	1	--	ng3¹		10	MN EU EA WA	1190
	rs5748623^1,2	A,C,F,H	15645124(+)	`ATGAAC/AAATGC`	1	L/F	mis¹		11	EU EA WA NA	978
	rs5748648^1,2	A,C,F,H	15660822(+)	`GCATCG/ATGTTT`	1	M/T	mis¹ ese³		8	EU EA WA	838
--	rs5994031^1,2	A,C,F,H	15683383(+)	`aatggT/Cttata`	1	--	ng3¹ tfbs³		4	EU EA WA	404

About this table

HapMap Linkage Disequilibrium images for XKR3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611674

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for XKR3 gene:

Identification of two new members, XPLAC and XTES, of the XK family. (PubMed id 16431037)^{2, 3, 4} Calenda G.... Lee S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 150165	HGNC: 28778	AceView: MGC57211	Ensembl:ENSG00000172967	euGenes: HUgn150165
ECgene: XKR3	H-InvDB: XKR3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for XKR3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XKR3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XKR3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XKR3		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for XKR3		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search Novus for antibodies for XKR3

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XKR3 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for XKR3

Summaries
for XKR3

Genomic Location
for XKR3

Proteins
for XKR3

Protein Domains/
Families
for XKR3

Gene Function
for XKR3

Pathways & Interactions
for XKR3

Drugs & Compounds
for XKR3

Transcripts
for XKR3

Expression
for XKR3

Orthologs
for XKR3

Paralogs
for XKR3

SNPs/Variants
for XKR3

Disorders & Mutations
for XKR3

Medical News
for XKR3

Publications
for XKR3

Search for XKR3

Genome Databases showing XKR3

Other Databases showing XKR3

Specialized Databases showing XKR3

Licensable Technologies
for XKR3

Services
for XKR3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XKR3 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor XKR3

Summariesfor XKR3

Genomic Locationfor XKR3

Proteinsfor XKR3

Protein Domains/Familiesfor XKR3

Gene Functionfor XKR3

Pathways & Interactionsfor XKR3

Drugs & Compoundsfor XKR3

Transcriptsfor XKR3

Expression for XKR3

Orthologsfor XKR3

Paralogsfor XKR3

SNPs/Variantsfor XKR3

Disorders & Mutationsfor XKR3

Medical Newsfor XKR3

Publicationsfor XKR3

Search for XKR3

Genome Databases showing XKR3

Other Databases showing XKR3

Specialized Databases showing XKR3

Licensable Technologiesfor XKR3

Servicesfor XKR3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XKR3

Summaries
for XKR3

Genomic Location
for XKR3

Proteins
for XKR3

Protein Domains/
Families
for XKR3

Gene Function
for XKR3

Pathways & Interactions
for XKR3

Drugs & Compounds
for XKR3

Transcripts
for XKR3

Expression
for XKR3

Orthologs
for XKR3

Paralogs
for XKR3

SNPs/Variants
for XKR3

Disorders & Mutations
for XKR3

Medical News
for XKR3

Publications
for XKR3

Licensable Technologies
for XKR3

Services
for XKR3