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Aliases for XKR3 Gene

Aliases for XKR3 Gene

  • XK, Kell Blood Group Complex Subunit-Related Family, Member 3 2 3
  • XRG3 3 4 6
  • XTES 3 4 6
  • X Kell Blood Group Precursor-Related Family, Member 3 2 3
  • X Kell Blood Group-Related 3 3 4
  • XK-Related Protein 3 3
  • Expressed In Testis 3

External Ids for XKR3 Gene

Previous GeneCards Identifiers for XKR3 Gene

  • GC22M015639
  • GC22M017264
  • GC22M001083

Summaries for XKR3 Gene

Entrez Gene Summary for XKR3 Gene

  • XKRX (MIM 300684) and XKR3 are homologs of the Kell blood group precursor XK (MIM 314850), which is a putative membrane transporter and a component of the XK/Kell complex of the Kell blood group system (Calenda et al., 2006 [PubMed 16431037]).[supplied by OMIM, Mar 2008]

GeneCards Summary for XKR3 Gene

XKR3 (XK, Kell Blood Group Complex Subunit-Related Family, Member 3) is a Protein Coding gene. An important paralog of this gene is XKRX.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR3 Gene

Genomics for XKR3 Gene

Regulatory Elements for XKR3 Gene

Genomic Location for XKR3 Gene

Start:
16,783,412 bp from pter
End:
16,821,699 bp from pter
Size:
38,288 bases
Orientation:
Minus strand

Genomic View for XKR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XKR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR3 Gene

Proteins for XKR3 Gene

  • Protein details for XKR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GH77-XKR3_HUMAN
    Recommended name:
    XK-related protein 3
    Protein Accession:
    Q5GH77
    Secondary Accessions:
    • B2RPN1
    • Q52PG8
    • Q8N7E1

    Protein attributes for XKR3 Gene

    Size:
    459 amino acids
    Molecular mass:
    53448 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XKR3 Gene

Proteomics data for XKR3 Gene at MOPED

Post-translational modifications for XKR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKR3 Gene

Domains for XKR3 Gene

Protein Domains for XKR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XKR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5GH77

UniProtKB/Swiss-Prot:

XKR3_HUMAN :
  • Q5GH77
Family:
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR3: view

No data available for Gene Families for XKR3 Gene

Function for XKR3 Gene

Phenotypes for XKR3 Gene

GenomeRNAi human phenotypes for XKR3:
genes like me logo Genes that share phenotypes with XKR3: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XKR3 Gene

Localization for XKR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XKR3 Gene COMPARTMENTS Subcellular localization image for XKR3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for XKR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR3: view

Pathways for XKR3 Gene

SuperPathways for XKR3 Gene

No Data Available

Interacting Proteins for XKR3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331704%0d%0a9606.ENSP00000184183%0d%0a
Selected Interacting proteins: ENSP00000331704 for XKR3 Gene via STRING

Symbol External ID(s) Details
ROPN1

Gene Ontology (GO) - Biological Process for XKR3 Gene

None

No data available for Pathways by source for XKR3 Gene

Transcripts for XKR3 Gene

mRNA/cDNA for XKR3 Gene

(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR3 Gene

XK, Kell blood group complex subunit-related family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XKR3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for XKR3 Gene

GeneLoc Exon Structure for
XKR3
ECgene alternative splicing isoforms for
XKR3

Expression for XKR3 Gene

mRNA expression in normal human tissues for XKR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XKR3 Gene

This gene is overexpressed in Testis (35.0) and Whole Blood (10.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for XKR3 Gene

SOURCE GeneReport for Unigene cluster for XKR3 Gene Hs.356069

mRNA Expression by UniProt/SwissProt for XKR3 Gene

Q5GH77-XKR3_HUMAN
Tissue specificity: Expressed predominantly, if not exclusively, in testis.
genes like me logo Genes that share expressions with XKR3: view

Orthologs for XKR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XKR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XKR3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii xkrx 36
  • 33 (a)
OneToMany
Species with no ortholog for XKR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XKR3 Gene

ENSEMBL:
Gene Tree for XKR3 (if available)
TreeFam:
Gene Tree for XKR3 (if available)

Paralogs for XKR3 Gene

Paralogs for XKR3 Gene

Selected SIMAP similar genes for XKR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with XKR3: view

Variants for XKR3 Gene

Sequence variations from dbSNP and Humsavar for XKR3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs175138 -- 16,823,242(+) ACAAT(A/G)ATAAC upstream-variant-2KB
rs175139 -- 16,823,356(+) ATTGA(C/T)ATCAT upstream-variant-2KB
rs738044 -- 16,816,668(-) AAAAA(C/T)ACATT intron-variant
rs738045 -- 16,801,041(-) ATGCT(C/T)CTTTC intron-variant
rs738046 -- 16,800,502(-) AAAAT(C/T)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XKR3 Gene

Variant ID Type Subtype PubMed ID
dgv172e55 CNV Gain 17911159
dgv1376e1 CNV Complex 17122850
nsv471178 CNV Gain 18288195
nsv517059 CNV Gain+Loss 19592680
nsv527637 CNV Gain 19592680
dgv540n27 CNV Gain 19166990
dgv814e199 CNV Deletion 23128226
nsv828922 CNV Loss 20364138
nsv459333 CNV Loss 19166990
nsv834117 CNV Gain 17160897

Relevant External Links for XKR3 Gene

HapMap Linkage Disequilibrium report
XKR3
Human Gene Mutation Database (HGMD)
XKR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR3 Gene

Disorders for XKR3 Gene

Relevant External Links for XKR3

Human Genome Epidemiology (HuGE) Navigator
XKR3
genes like me logo Genes that share disorders with XKR3: view

No data available for UniProtKB/Swiss-Prot for XKR3 Gene

Publications for XKR3 Gene

  1. Identification of two new members, XPLAC and XTES, of the XK family. (PMID: 16431037) Calenda G. … Lee S. (Gene 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Robust, high-throughput solution for blood group genotyping. (PMID: 20560530) Le Goff G.C. … Marquette C.A. (Anal. Chem. 2010) 3

Products for XKR3 Gene

Sources for XKR3 Gene

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