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Aliases for XKR3 Gene

Aliases for XKR3 Gene

  • XK Related 3 2 3
  • XK, Kell Blood Group Complex Subunit-Related Family, Member 3 2 3
  • X Kell Blood Group Precursor-Related Family, Member 3 2 3
  • X-Linked Kx Blood Group Related 3 3 5
  • X Kell Blood Group-Related 3 3 4
  • XRG3 3 4
  • XTES 3 4
  • Expressed In Testis 3

External Ids for XKR3 Gene

Previous GeneCards Identifiers for XKR3 Gene

  • GC22M015639
  • GC22M017264
  • GC22M001083

Summaries for XKR3 Gene

Entrez Gene Summary for XKR3 Gene

  • XKRX (MIM 300684) and XKR3 are homologs of the Kell blood group precursor XK (MIM 314850), which is a putative membrane transporter and a component of the XK/Kell complex of the Kell blood group system (Calenda et al., 2006 [PubMed 16431037]).[supplied by OMIM, Mar 2008]

GeneCards Summary for XKR3 Gene

XKR3 (XK Related 3) is a Protein Coding gene. An important paralog of this gene is XK.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR3 Gene

Genomics for XKR3 Gene

Regulatory Elements for XKR3 Gene

Enhancers for XKR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around XKR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for XKR3 Gene

16,783,412 bp from pter
16,821,699 bp from pter
38,288 bases
Minus strand

Genomic View for XKR3 Gene

Genes around XKR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR3 Gene

Proteins for XKR3 Gene

  • Protein details for XKR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    XK-related protein 3
    Protein Accession:
    Secondary Accessions:
    • B2RPN1
    • Q52PG8
    • Q8N7E1

    Protein attributes for XKR3 Gene

    459 amino acids
    Molecular mass:
    53448 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XKR3 Gene

Proteomics data for XKR3 Gene at MOPED

Post-translational modifications for XKR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKR3 Gene

Domains & Families for XKR3 Gene

Gene Families for XKR3 Gene

Protein Domains for XKR3 Gene


Suggested Antigen Peptide Sequences for XKR3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the XK family.
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR3: view

Function for XKR3 Gene

genes like me logo Genes that share phenotypes with XKR3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XKR3 Gene

Localization for XKR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for XKR3 Gene COMPARTMENTS Subcellular localization image for XKR3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for XKR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with XKR3: view

Pathways & Interactions for XKR3 Gene

SuperPathways for XKR3 Gene

No Data Available

Interacting Proteins for XKR3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000331704 for XKR3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for XKR3 Gene


No data available for Pathways by source and SIGNOR curated interactions for XKR3 Gene

Drugs & Compounds for XKR3 Gene

No Compound Related Data Available

Transcripts for XKR3 Gene

mRNA/cDNA for XKR3 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR3 Gene

XK, Kell blood group complex subunit-related family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XKR3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4

Relevant External Links for XKR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XKR3 Gene

mRNA expression in normal human tissues for XKR3 Gene

mRNA differential expression in normal tissues according to GTEx for XKR3 Gene

This gene is overexpressed in Testis (x35.0) and Whole Blood (x10.6).

Protein differential expression in normal tissues from HIPED for XKR3 Gene

This gene is overexpressed in Blymphocyte (51.3) and Monocytes (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for XKR3 Gene

SOURCE GeneReport for Unigene cluster for XKR3 Gene Hs.356069

mRNA Expression by UniProt/SwissProt for XKR3 Gene

Tissue specificity: Expressed predominantly, if not exclusively, in testis.
genes like me logo Genes that share expression patterns with XKR3: view

Protein tissue co-expression partners for XKR3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for XKR3 Gene

Orthologs for XKR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XKR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
(Pan troglodytes)
Mammalia XKR3 36
  • 93 (a)
(Gallus gallus)
Aves -- 36
  • 39 (a)
(Danio rerio)
Actinopterygii xkrx 36
  • 33 (a)
Species with no ortholog for XKR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XKR3 Gene

Gene Tree for XKR3 (if available)
Gene Tree for XKR3 (if available)

Paralogs for XKR3 Gene

Paralogs for XKR3 Gene

(4) SIMAP similar genes for XKR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with XKR3: view

Variants for XKR3 Gene

Sequence variations from dbSNP and Humsavar for XKR3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5748648 - 16,799,932(+) GCATC(A/G)TGTTT reference, missense
rs9605146 - 16,784,304(+) CTATC(A/G)GCGGT reference, missense
rs5748623 - 16,784,234(+) ATGAA(A/C)AATGC reference, missense
rs5748622 - 16,783,675(+) GGAGT(G/T)ACAGT reference, missense
rs2080203 -- 16,805,439(+) aaatg(G/T)aaata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XKR3 Gene

Variant ID Type Subtype PubMed ID
dgv172e55 CNV Gain 17911159
dgv1376e1 CNV Complex 17122850
nsv471178 CNV Gain 18288195
nsv517059 CNV Gain+Loss 19592680
nsv527637 CNV Gain 19592680
dgv540n27 CNV Gain 19166990
dgv814e199 CNV Deletion 23128226
nsv828922 CNV Loss 20364138
nsv459333 CNV Loss 19166990
nsv834117 CNV Gain 17160897

Variation tolerance for XKR3 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XKR3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR3 Gene

Disorders for XKR3 Gene

Relevant External Links for XKR3

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for XKR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XKR3 Gene

Publications for XKR3 Gene

  1. Identification of two new members, XPLAC and XTES, of the XK family. (PMID: 16431037) Calenda G. … Lee S. (Gene 2006) 2 3 4 67
  2. NUP214 fusion genes in acute leukemia (Review). (PMID: 25120641) Zhou M.H. … Yang Q.M. (Oncol Lett 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Robust, high-throughput solution for blood group genotyping. (PMID: 20560530) Le Goff G.C. … Marquette C.A. (Anal. Chem. 2010) 3
  5. Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts. (PMID: 19835606) Levin J.Z. … Gnirke A. (Genome Biol. 2009) 3

Products for XKR3 Gene

Sources for XKR3 Gene