XK Gene
protein-coding GIFtS: 53
GCID: GC0XP037545
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X-linked Kx blood group (McLeod syndrome)(Previous names: Kell blood group precursor (McLeod phenotype), XK, Kell...)
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Aliases for XK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| X-Linked Kx Blood Group (McLeod Syndrome)1 2 | | XK-Related Protein 12 3 | | XKR11 2 3 | | Kx1 | | X1k1 2 | | KX2 | | Kell Blood Group Precursor (McLeod Phenotype)1 2 | | MCLDS2 | | XK, Kell Blood Group Complex Subunit (McLeod Syndrome)1 2 | | Membrane Transport Protein XK2 | | Kell Complex 37 KDa Component2 3 | | XRG13 | | Kx Antigen2 3 | | |
Export aliases for XK gene to outside databasesPrevious GC identifers: GC0XP035650 GC0XP035832 GC0XP036389 GC0XP036576 GC0XP036575 GC0XP037301 GC0XP037430 GC0XP035290 |
Summaries for XK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for XK: This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have beenassociated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscularand hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membranetransport proteins. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: XK_HUMAN, P51811Function: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides
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Genomic Views for XK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the XK gene promoter: STAT5B STAT1 STAT4 STAT1beta STAT5A Nkx2-5 STAT1alpha STAT2 STAT3 Other transcription factors
Search SABiosciences Chromatin IP Primers for XK
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XK |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.1 Ensembl cytogenetic band: Xp21.1 HGNC cytogenetic band: Xp21.1XK Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP037545: view genomic region
(about GC identifiers)
Start:
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37,545,012 bp from pter |
End:
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37,591,383 bp from pter |
Size:
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46,372 bases |
Orientation:
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plus strand |
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Proteins for XK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: XK_HUMAN, P51811 (See
protein sequence)Recommended Name: Membrane transport protein XK Size: 444 amino acids; 50902 Da
Subunit: Heterodimer with Kell; disulfide-linked
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q4TTN6 Q8IUK6 Q9UC77Explore the universe of human proteins at neXtProt for XK: NX_P51811
Post-translational modifications:
Not glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51811 XK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066569.1 ENSEMBL proteins: ENSP00000367879 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
XK for ontologies About GeneDecksing
XK Antibody Products: Assay Products for XK: |
Protein
Domains / Families for XK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XK for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P51811ProtoNet protein and cluster: P51811 UniProtKB/Swiss-Prot: XK_HUMAN, P51811Similarity: Belongs to the XK family |
Function for XK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: XK_HUMAN, P51811Function: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XK (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XK OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XK (NM_004514) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XK  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XK |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
XK for ontologies About GeneDecksing
|
Pathways & Interactions for XK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XK
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
 5 Interacting proteins for XK (P518113 ENSP000003678794) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
XK for ontologies About GeneDecksing
|
Drugs & Compounds for XK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
XK for compounds About GeneDecksing
Browse Tocris compounds for XK
1 HMDB Compound for XK About this table 2 Novoseek chemical compound relationships for XK gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
10.1 |
2 |
9593744 (1), 11375401 (1) |
| cysteine |
0 |
1 |
9593744 (1) |
Search CenterWatch for drugs/clinical trials and news about XK 
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Transcripts for XK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for XK gene: NM_021083.2 Unigene Cluster for XK: X-linked Kx blood group (McLeod syndrome) Hs.78919 [show with all ESTs]Unigene Representative Sequence: Z326841 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000378616(uc004ddq.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XK (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XK OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XK (NM_004514) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XK  |
Additional cDNA sequence: AY534238.1 BC036019.1 Z32684.2 2 DOTS entries: DT.408985 DT.65284751 24/35 AceView cDNA sequences (see all 35): CB118001 F05652 NM_021083 Z44247 Z41101 AI697050 F08018 Z45634 F01908 AI174882 CK429656 F04531 AI351187 BC036019 BX503408 Z32684 AL120168 BX479653 BF445285 BX480634 F03944 BF445286 BI461092 Z44993 GeneLoc Exon Structure
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Expression for XK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XK expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCACTTGGAA
About this image See XK Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for XK
SOURCE GeneReport for Unigene cluster: Hs.78919 UniProtKB/Swiss-Prot: XK_HUMAN, P51811Tissue specificity: High levels in skeletal muscle, heart, brain, and pancreas; low levels in placenta, lung, liver,and kidney SABiosciences Custom PCR Arrays for XK
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XK Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat XK | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XK | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XK | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XK |
Orthologs for XK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for XK gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
XK1 |
X-linked Kx blood group (McLeod syndrome) |
72.31(n) 74.48(a) |
  |
427991 NM_001034822.1 NP_001029994.1 |
lizard (Anolis carolinensis) |
Reptilia |
XK6 |
-- |
69(a) |
1 ↔ 1 |
3(132126954-132165941) |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.12212 |
Transcribed sequence with weak similarity to protein more |
75.97(n) |
  |
142003978 |
zebrafish (Danio rerio) |
Actinopterygii |
xk1 |
X-linked Kx blood group (McLeod syndrome) |
65.82(n) 69.13(a) |
  |
497076 NM_001012254.1 NP_001012254.1 |
ENSEMBL Gene Tree for XK (if available) TreeFam Gene Tree for XK (if available)  |
Paralogs for XK gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for XK gene
- XKRX2 XKR32
2 SIMAP similar genes for XK using alignment to 2 protein entries: XK_HUMAN (see all proteins):XKRX XKR3
XK for paralogs About GeneDecksing
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Genomic Variants for XK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| UniProtKB/Swiss-Prot: XK_HUMAN, P51811Polymorphism: XK is responsible for the Kx blood group system
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr X pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for XK (37545012 - 37591383 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for XK: -- Human Gene Mutation Database (HGMD): XK
Locus Specific Mutation Databases (LSDB): XK Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XK |
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Disorders
/ Diseases for XK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XK for disorders About GeneDecksing
OMIM gene information: 314850
OMIM disorders: --
UniProtKB/Swiss-Prot: XK_HUMAN, P51811
Defects in XK are the cause of McLeod syndrome (MLS) [MIM:300842]. It is an X-linked multisystem disordercharacterized by late onset abnormalities in the neuromuscular and hematopoietic systems 16 diseases for XK: About MalaCardsmcleod syndrome mcleod neuroacanthocytosis syndrome neuroacanthocytosis mcleod syndrome with neuroacanthosis acanthocytosis calpainopathy chorea chronic granulomatous disease dilated cardiomyopathy huntington's disease mood disorder cardiomyopathy protein s deficiency myopathy cerebritis schizophrenia 2 diseases from the University of Copenhagen DISEASES database for XK:Neuroacanthocytosis Ornithine carbamoyltransferase deficiency 9 Novoseek disease relationships for XK gene About this table
GeneTests: XK McLeod Neuroacanthocytosis Syndrome Genetic Association Database (GAD): XK Human Genome Epidemiology (HuGE) Navigator: XK (18 documents) Export disorders for XK gene to outside databases
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Publications for XK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XK gene, integrated from 9 sources (see all 63): (articles sorted by number of sources associating them with XK) | |  | Utopia: connect your pdf to the dynamic world of online information |
- McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement. (PubMed id 12823753)1, 2, 4, 9 Jung H.H.... Frey B.M. (2003)
- Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein. (PubMed id 8004674)1, 2, 3 Ho M.... Monaco A.P. (1994)
- Association of XK and Kell blood group proteins. (PubMed id 9593744)1, 2, 9 Russo D.... Lee S. (1998)
- Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients. (PubMed id 7737196)1, 2, 9 Khamlichi S....Bertrand O. (1995)
- McLeod neuroacanthocytosis: genotype and phenotype. (PubMed id 11761473)1, 2, 9 Danek A.... Monaco A.P. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Point mutations causing the McLeod phenotype. (PubMed id 11961232)1, 2 Russo D.C.... Redman C.M. (2002)
- A murine monoclonal antibody against Kx protein which reacts also with beta-spectrin. (PubMed id 10849386)1, 9 Carbonnet F....Bertrand O. (2000)
- The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system. (PubMed id 17379193)1, 9 Claperon A....Ouimet T. (2007)
- Immunochemical analysis of the Kx protein from human red cells of different Kell phenotypes using antibodies raised against synthetic peptides. (PubMed id 9074432)1, 9 Carbonnet F....Bertrand O. (1997)
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External Searches for XK gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing XK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for XK | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/XK | | SeattleSNPs | http://pga.gs.washington.edu/data/xk/ |
|
| | |
About This Section
| Patent Information for XK gene: Search GeneIP for patents involving XK
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for XK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for XK | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XK | | OriGene Protein Over-expression Lysate for XK | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for XK | | OriGene 3'-UTR Clone for XK | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XK | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for XK | | OriGene Custom Protein Services for XK | | OriGene Custom Immunoassay Development | | |
| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XK | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XK | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XK | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XK | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XK | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XK |
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| | | Search Tocris compounds for XK |
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 | | XK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XK |
|  |  |  | | | Search ThermoFisher Antibodies for XK |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XK |
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