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XK Gene

protein-coding   GIFtS: 54
GCID: GC0XP037545

X-Linked Kx Blood Group (McLeod Syndrome)

(Previous names: Kell blood group precursor (McLeod phenotype), XK, Kell...)
(Previous symbols: NA, NAC)
  See XK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
X-Linked Kx Blood Group (McLeod Syndrome)1 2     Kell Complex 37 KDa Component2 3
Kx Antigen1 2 3     XKR12 3
NA1 2     XK-Related Protein 12 3
NAC1 2     MCLDS2 5
Kell Blood Group Precursor (McLeod Phenotype)1 2     KX2
neuroacanthocytosis1 2     X1k2
neurocanthocytosis1 2     Membrane Transport Protein XK2
XK, Kell Blood Group Complex Subunit (McLeod Syndrome)1 2     XRG13

External Ids:    HGNC: 128111   Entrez Gene: 75042   Ensembl: ENSG000000475977   OMIM: 3148505   UniProtKB: P518113   

Export aliases for XK gene to outside databases

Previous GC identifers: GC0XP035650 GC0XP035832 GC0XP036389 GC0XP036576 GC0XP036575 GC0XP037301 GC0XP037430 GC0XP035290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XK Gene:
This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have
been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the
neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and
eukaryotic membrane transport proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for XK Gene:
XK (X-linked Kx blood group (McLeod syndrome)) is a protein-coding gene. Diseases associated with XK include mcleod syndrome with or without chronic granulomatous disease, and neuroacanthocytosis. GO annotations related to this gene include transporter activity. An important paralog of this gene is XKRX.

UniProtKB/Swiss-Prot: XK_HUMAN, P51811
Function: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the XK gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT5A   Nkx2-5   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXK promoter sequence
   Search Chromatin IP Primers for XK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp21.1   HGNC cytogenetic band: Xp21.1

XK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XK gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP037545:  view genomic region     (about GC identifiers)

Start:
37,545,012 bp from pter      End:
37,591,383 bp from pter
Size:
46,372 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: XK_HUMAN, P51811 (See protein sequence)
Recommended Name: Membrane transport protein XK  
Size: 444 amino acids; 50902 Da
Subunit: Heterodimer with Kell; disulfide-linked
Secondary accessions: Q4TTN6 Q8IUK6 Q9UC77

Explore the universe of human proteins at neXtProt for XK: NX_P51811

Explore proteomics data for XK at MOPED

Post-translational modifications: 

  • Not glycosylated1
  • Modification sites at neXtProt

  • See XK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066569.1  
    ENSEMBL proteins: 
     ENSP00000367879  

    XK Human Recombinant Protein Products:

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    antibodies-online peptides for XK

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    antibodies-online antibodies for XK (30 products) 

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    antibodies-online kits for XK (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bloodgroup: Blood group antigens

    1 InterPro protein domain:
     IPR018629 Transport_prot_XK

    Graphical View of Domain Structure for InterPro Entry P51811

    ProtoNet protein and cluster: P51811

    UniProtKB/Swiss-Prot: XK_HUMAN, P51811
    Similarity: Belongs to the XK family


    Find genes that share domains with XK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XK_HUMAN, P51811
    Function: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS8004674
    GO:0005515protein binding IPI7737196
         
    Find genes that share ontologies with XK           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Xk (no phenotypes)

    Find genes that share phenotypes with XK           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for XK

    miRNA
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    miRTarBase miRNAs that target XK:
    hsa-mir-29c-3p (MIRT044236), hsa-mir-98-5p (MIRT027860), hsa-mir-215-5p (MIRT024667), hsa-mir-31-3p (MIRT038931), hsa-mir-192-5p (MIRT026742), hsa-mir-26b-5p (MIRT030081)

    Block miRNA regulation of human, mouse, rat XK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate XK (see all 36):
    hsa-miR-194* hsa-miR-4307 hsa-miR-640 hsa-let-7d hsa-miR-374a hsa-let-7g hsa-let-7a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidXK 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XK_HUMAN, P51811: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane TAS9647734

    Find genes that share ontologies with XK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XK
    Interactions:

        GeneGlobe Interaction Network for XK

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for XK (P518113 ENSP000003678794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KELP232763, ENSP000003474094I2D: score=2 STRING: ENSP00000347409
    CSNK2A1P684003, ENSP000002172444I2D: score=3 STRING: ENSP00000217244
    PRKCAP172523, ENSP000002843844I2D: score=2 STRING: ENSP00000284384
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    CLGNENSP000003266994STRING: ENSP00000326699
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8004674
    GO:0006865amino acid transport IEA--

    Find genes that share ontologies with XK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XK

    1 HMDB Compound for XK    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    2 Novoseek inferred chemical compound relationships for XK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 10.1 2 9593744 (1), 11375401 (1)
    cysteine 0 1 9593744 (1)



    Find genes that share compounds with XK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XK gene: 
    NM_021083.2  

    Unigene Cluster for XK:

    X-linked Kx blood group (McLeod syndrome)
    Hs.78919  [show with all ESTs]
    Unigene Representative Sequence: Z32684
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000378616(uc004ddq.3)
    miRNA
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    hsa-miR-194* hsa-miR-4307 hsa-miR-640 hsa-let-7d hsa-miR-374a hsa-let-7g hsa-let-7a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidXK 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AY534238.1 BC036019.1 Z32684.2 

    2 DOTS entries:

    DT.408985  DT.65284751 

    Selected AceView cDNA sequences (see all 35):

    CB118001 F04531 Z44247 AI174882 F08018 Z41101 AI697050 F05652 
    CK429656 F01908 NM_021083 Z45634 BC036019 AI351187 BX480634 F03944 
    BF445285 BI461092 Z44993 Z32684 BX503409 BX503408 BF445286 BF448142 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACTTGGAA
    XK Expression
    About this image


    XK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
    XK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78919

    UniProtKB/Swiss-Prot: XK_HUMAN, P51811
    Tissue specificity: High levels in skeletal muscle, heart, brain, and pancreas; low levels in placenta, lung,
    liver, and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for XK gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xk1 , 5 Kell blood group precursor (McLeod phenotype) homolog1, 5 82.66(n)1
    82.43(a)1
      X (4.22 cM)5
    224391  NM_023500.21  NP_075989.11 
     92727565 
    chicken
    (Gallus gallus)
    Aves XK1 X-linked Kx blood group (McLeod syndrome) 72.38(n)
    74.31(a)
      427991  NM_001034822.1  NP_001029994.1 
    lizard
    (Anolis carolinensis)
    Reptilia XK6
    X-linked Kx blood group (McLeod syndrome)
    57(a)
    1 ↔ 1
    3(132126609-132168607)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.12212 Transcribed sequence with weak similarity to protein more 75.97(n)    142003978 
    zebrafish
    (Danio rerio)
    Actinopterygii xk1 X-linked Kx blood group (McLeod syndrome) 63.99(n)
    66.19(a)
      497076  NM_001012254.1  NP_001012254.1 


    ENSEMBL Gene Tree for XK (if available)
    TreeFam Gene Tree for XK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for XK gene
    XKRX2  XKR32  
    2 SIMAP similar genes for XK using alignment to 2 protein entries:     XK_HUMAN (see all proteins):
    XKRX    XKR3

    Find genes that share paralogs with XK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    XK_HUMAN, P51811: XK is responsible for the Kx blood group system


    Selected SNPs for XK (see all 575)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289336901,2,,4
    CMcLeod syndrome (MLS)4 pathogenic137503806(+) TGTTCC/TGCTGG 2 R C mis1 ese30--------
    VAR_0235814
    McLeod syndrome (MLS)4--see VAR_0235812 E K mis40--------
    VAR_0138174
    McLeod syndrome (MLS)4--see VAR_0138172 R G mis40--------
    rs1048949541,2
    Cpathogenic137503821(+) CTGTAC/TAGCTG 2 Q * stg10--------
    rs1048949531,2
    Cpathogenic137503867(+) TAATTA/GGTACC 2 * W stg10--------
    rs1837251911,2
    --37459615(+) AATGCA/GATACA 1 -- us2k10--------
    rs1872708871,2
    --37459857(+) TGATAC/TTGCTT 1 -- us2k10--------
    rs625885221,2
    C,F--37459882(+) AGTTTA/GCTCAC 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1901094701,2
    --37460582(+) GCCTGA/GAGATT 1 -- us2k10--------
    rs726194201,2
    C--37460586(+) GAAGAC/TTGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for XK (37545012 - 37591383 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for XK: --
    Human Gene Mutation Database (HGMD): XK
    Locus Specific Mutation Databases (LSDB): XK

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XK
    DNA2.0 Custom Variant and Variant Library Synthesis for XK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 314850   
    OMIM disorders: 300842  
    UniProtKB/Swiss-Prot: XK_HUMAN, P51811
  • McLeod syndrome (MLS) [MIM:300842]: A multisystem disorder characterized by the absence of red blood cell
    Kx antigen, weak expression of Kell red blood cell antigens, acanthocytosis, and compensated hemolysis. Most
    carriers of this McLeod blood group phenotype have acanthocytosis and elevated serum creatine kinase levels and
    are prone to develop a severe neurologic disorder resembling Huntington disease. Additional symptoms include
    generalized seizures, neuromuscular symptoms leading to weakness and atrophy, and cardiomyopathy mainly
    manifesting with atrial fibrillation, malignant arrhythmias, and dilated cardiomyopathy. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 10 diseases for XK:    
    About MalaCards
    mcleod syndrome with or without chronic granulomatous disease    neuroacanthocytosis    mcleod neuroacanthocytosis syndrome    mcleod syndrome
    chorea-acanthocytosis    acanthocytosis    mood disorder    chorea
    calpainopathy    chronic granulomatous disease

    1 disease from the University of Copenhagen DISEASES database for XK:
    Neuroacanthocytosis

    Find genes that share disorders with XK           About GenesLikeMe

    9 Novoseek inferred disease relationships for XK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuroacanthocytosis 96.5 7 9268240 (2), 10882128 (1), 11104227 (1), 17277857 (1) (see all 6)
    chorea-acanthocytosis 83.5 1 11761473 (1)
    granulomatous disease chronic 67.9 3 11032622 (1), 17300882 (1), 18167163 (1)
    myopathy 62.6 5 11562915 (2), 1734714 (1), 12823753 (1)
    muscular dystrophy duchenne 52.3 2 11032622 (1), 17300882 (1)
    muscular dystrophies 50.7 1 10791880 (1)
    huntington disease 45.1 1 11761473 (1)
    atrophy 35 3 11562915 (1), 17469188 (1)
    cardiomyopathy 25.1 1 9268240 (1)

    GeneTests: XK
    GeneReviews: XK
    Genetic Association Database (GAD): XK
    Human Genome Epidemiology (HuGE) Navigator: XK (18 documents)

    Export disorders for XK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XK gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with XK)
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    1. McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement. (PubMed id 12823753)1, 2, 4, 9 Jung H.H.... Frey B.M. (Transfusion 2003)
    2. McLeod neuroacanthocytosis: genotype and phenotype. (PubMed id 11761473)1, 2, 3, 9 Danek A.... Monaco A.P. (Ann. Neurol. 2001)
    3. Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein. (PubMed id 8004674)1, 2, 3 Ho M.... Monaco A.P. (Cell 1994)
    4. Association of XK and Kell blood group proteins. (PubMed id 9593744)1, 2, 9 Russo D.... Lee S. (J. Biol. Chem. 1998)
    5. Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients. (PubMed id 7737196)1, 2, 9 Khamlichi S....Bertrand O. (Eur. J. Biochem. 1995)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Point mutations causing the McLeod phenotype. (PubMed id 11961232)1, 2 Russo D.C.... Redman C.M. (Transfusion 2002)
    8. A murine monoclonal antibody against Kx protein which reacts also with beta-spectrin. (PubMed id 10849386)1, 9 Carbonnet F....Bertrand O. (Transfus Med 2000)
    9. The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system. (PubMed id 17379193)1, 9 ClapAcron A....Ouimet T. (Brain Res. 2007)
    10. Immunochemical analysis of the Kx protein from human red cells of different Kell phenotypes using antibodies raised against synthetic peptides. (PubMed id 9074432)1, 9 Carbonnet F....Bertrand O. (Br. J. Haematol. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7504 HGNC: 12811 AceView: XK Ensembl:ENSG00000047597 euGenes: HUgn7504
    ECgene: XK H-InvDB: XK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for XK Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=XK[genesymbol]
    SeattleSNPshttp://pga.gs.washington.edu/data/xk/

    (Patent information from GeneIP,
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    Patent Information for XK gene:
    Search GeneIP for patents involving XK

    GeneCards and IP:
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