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XIRP2 Gene

protein-coding GIFtS: 49
GCID: GC02P167744

Xin Actin-Binding Repeat Containing 2

(Previous name: cardiomyopathy associated 3)
(Previous symbol: CMYA3)

See XIRP2-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Xin Actin-Binding Repeat Containing 2¹ ²		xeplin²
CMYA3¹ ² ³ ⁵		Xin Actin-Binding Repeat-Containing Protein 2²
Cardiomyopathy Associated 3¹ ²		Xin Repeat Protein 2²
myomaxin¹ ²		Beta-xin³
Cardiomyopathy-Associated Protein 3² ³		Xeplin³
beta-xin²

External Ids:	HGNC: 14303¹	Entrez Gene: 129446²	Ensembl: ENSG00000163092⁷	OMIM: 609778⁵	UniProtKB: A4UGR9³

Export aliases for XIRP2 gene to outside databases

Previous GC identifers: GC02P167469 GC02P159640

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for XIRP2 Gene:

XIRP2 (xin actin-binding repeat containing 2) is a protein-coding gene. Diseases associated with XIRP2 include osteochondrosis. GO annotations related to this gene include actin binding. An important paralog of this gene is XIRP1.

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9

Function: Protects actin filaments from depolymerization

Gene Wiki entry for XIRP2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NT_005403.18 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the XIRP2 gene promoter:
Bach1 Pax-2 Pax-2a POU6F1 (c2) HNF-1A POU2F1 POU2F1b HNF-1 POU2F1a POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XIRP2 promoter sequence

Search Chromatin IP Primers for XIRP2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XIRP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q31.1

XIRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XIRP2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P167744: view genomic region (about GC identifiers)

Start:	167,744,997 bp from pter	End:	168,116,263 bp from pter
Size:	371,267 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9 (See protein sequence)

Recommended Name: Xin actin-binding repeat-containing protein 2

Size: 3374 amino acids; 382300 Da

Subunit: Interacts with ACTN2 (By similarity). Interacts with F-actin

Miscellaneous: 'Xin' means 'heart' in Chinese

Sequence caution: Sequence=AAH18673.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence; Sequence=AAY24138.1; Type=Erroneous gene model prediction; Sequence=CAD38624.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAD89958.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=CAD91141.2; Type=Miscellaneous discrepancy;

Note=Contaminating sequence;

1 PDB 3D structure from and Proteopedia for XIRP2:

4F14 (3D)

Secondary accessions: A0PJ94 B2BBS0 B2BBS1 B2BBS4 B3KVH0 Q53R52 Q5MJ67 Q702N7 Q86T36 Q86T38

Q86T46 Q86T51 Q86T53 Q86T55 Q86T79 Q86TB6 Q8N1M9 Q8N3R5 Q8TBV6

Alternative splicing: 7 isoforms: A4UGR9-1 A4UGR9-2 A4UGR9-3 A4UGR9-4 A4UGR9-5 A4UGR9-6 A4UGR9-7 (Variant in position: 757:R->G (in dbSNP:rs3749005). Variant in position: 885:V->G (in dbSNP:rs3749006). Variant in position: 905:E->Q (in dbSNP:rs16853344))

Explore the universe of human proteins at neXtProt for XIRP2: NX_A4UGR9

Explore proteomics data for XIRP2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See XIRP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts):

NP_001073278.1 NP_001186072.1 NP_001186073.1 NP_001186074.1 NP_689594.4

ENSEMBL proteins:

ENSP00000386454 ENSP00000386619 ENSP00000386840 ENSP00000387255 ENSP00000386981

ENSP00000386724 ENSP00000415541 ENSP00000295237

XIRP2 Human Recombinant Protein Products:

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	Search GeneTex for Proteins for XIRP2
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	antibodies-online peptides for XIRP2

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	antibodies-online antibodies for XIRP2 (5 products)

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	antibodies-online kits for XIRP2 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:

IPR012510 Actin-binding_Xin_repeat

Graphical View of Domain Structure for InterPro Entry A4UGR9

ProtoNet protein and cluster: A4UGR9

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9

Domain: Xin repeats bind F-actin

Similarity: Belongs to the Xin family

Similarity: Contains 28 Xin repeats

Find genes that share domains with XIRP2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: XIRP2_HUMAN, A4UGR9

Function: Protects actin filaments from depolymerization

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	--	--
GO:0051393	alpha-actinin binding	--	--

Find genes that share ontologies with XIRP2 About GenesLikeMe

Phenotypes:
10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Xirp2):

behavior/neurological	cardiovascular system	cellular	growth/size/body	homeostasis/metabolism
integument	liver/biliary system	mortality/aging	muscle	normal

Find genes that share phenotypes with XIRP2 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for XIRP2

miRNA Products:		miRTarBase miRNAs that target XIRP2: hsa-mir-335-5p (MIRT018886)

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Gene Editing
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XIRP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XIRP2
		Browse ESI BIO Cell Lines and PureStem Progenitors for XIRP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

XIRP2_HUMAN, A4UGR9: Cell junction. Note=Colocalizes with actin stress fibers (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	2
cytosol	1
extracellular	1
mitochondrion	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030018	Z disc	--	--
GO:0030054	cell junction	IEA	--

Find genes that share ontologies with XIRP2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for XIRP2
Interactions:

Search GeneGlobe Interaction Network for XIRP2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for XIRP2 (A4UGR9³ ENSP00000386840⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NSMAF	Q92636³, ENSP00000411012⁴	I2D: score=3 STRING: ENSP00000411012

About this table

Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003281	ventricular septum development	--	--
GO:0030036	actin cytoskeleton organization	IEA	--
GO:0045216	cell-cell junction organization	--	--
GO:0055008	cardiac muscle tissue morphogenesis	--	--

Find genes that share ontologies with XIRP2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for XIRP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for XIRP2 gene (6 alternative transcripts):

NM_001079810.3 NM_001199143.1 NM_001199144.1 NM_001199145.1 NM_152381.5 XM_006712256.1

Unigene Cluster for XIRP2:

Xin actin-binding repeat containing 2

Hs.73680 [show with all ESTs]

Unigene Representative Sequence: NM_152381

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409043 ENST00000409728(uc010fpn.3) ENST00000409195(uc002udx.3 uc010fpo.3)

ENST00000409273(uc010fpq.3) ENST00000409605(uc010fpr.3) ENST00000409756

ENST00000420519 ENST00000295237(uc002udy.3)

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		QuantiFast Probe-based Assays in human, mouse, rat XIRP2

Additional mRNA sequence:

AJ626901.1 AK056582.1 AK092683.1 AK096430.1 AK096907.1 AK097519.1 AK122889.1 AK123963.1

AK125495.1 AL831970.2 AL831985.1 AL832011.1 AL832331.1 AL832336.1 AL832360.1 AL832375.1

AL832382.1 AL832452.2 AL833291.2 AY820969.1 BC016370.1 BC018673.1 BC022446.1 BC022887.1

BC022888.1 BC070143.1 BC107799.1 BX647448.1 BX647645.1 BX647844.1 BX647845.1 BX647848.1

EF119711.1 EF119717.1 EF119718.1 EF119719.1 EF119720.1 EF119721.1 EF119722.1

8 DOTS entries:

DT.101984484 DT.213707 DT.95343202 DT.95185473 DT.100795194 DT.120951509 DT.100795191 DT.92439424

Selected AceView cDNA sequences (see all 200):

AJ626901 AL832452 BC022446 BX647448 AA195845 AW755252 BC070143 F28773

AK096907 Z28678 AA111946 BX500581 BX647645 AL596757 BC022888 AI803678

BC022887 AL832336 AK096430 F32854 C05081 F21569 AK122889 AK056582

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

XIRP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

XIRP2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Endothelium (Cardiovascular System)
Endothelial-like cells

Adipose (Muscoskeletal System)
Interscapular Brown Adipose Depot

Skeletal Muscle (Muscoskeletal System)

XIRP2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

XIRP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.73680

Custom PCR Arrays for XIRP2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for XIRP2 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Xirp2^{1 , 5}	xin actin-binding repeat containing 2^{1, 5}	79.95(n)¹ 72.86(a)¹		2 (39.31 cM)⁵ 241431¹ NM_001024618.2¹ NP_001019789.1¹ 67446002⁵
lizard (Anolis carolinensis)	Reptilia	XIRP2⁶	xin actin-binding repeat containing 2	47(a)	1 ↔ 1	GL343214.1(229056-439293)
zebrafish (Danio rerio)	Actinopterygii	xirp2a⁶ xirp2b⁶	xin actin-binding repeat containing 2b	36(a) 35(a)	1 ↔ many 1 ↔ many	6(10080895-10144304) ENSDARG00000071113 9(50511653-50556206) ENSDARG00000091090

ENSEMBL Gene Tree for XIRP2 (if available)
TreeFam Gene Tree for XIRP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for XIRP2 gene

XIRP1²

Find genes that share paralogs with XIRP2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140208720^1,2	C	untested¹	167760256(+)	`ACCAGA/GGAATA`	6	R	syn¹		0	--	--	--	--
rs137994034^1,2		--	167743024(+)	`TGACTC/GAAAGG`	3	--	us2k¹		0	--	--	--	--
rs114833261^1,2	C,F	--	167743038(+)	`GCCTCA/GTTTCA`	3	--	us2k¹		1		WA	118
rs182417926^1,2		--	167743104(+)	`CCCATC/TGCAAC`	3	--	us2k¹		0	--	--	--	--
rs186639288^1,2		--	167743216(+)	`TCATAA/CTTACC`	3	--	us2k¹		0	--	--	--	--
rs142057486^1,2	C	--	167743262(+)	`TGCCAC/TAACTT`	3	--	us2k¹		0	--	--	--	--
rs115631329^1,2	F	--	167743292(+)	`TTTATA/GTCTAA`	3	--	us2k¹		1		WA	118
rs10497303^1,2	C,F,H	--	167743294(+)	`TATATC/GTAACC`	3	--	us2k¹		28		NS NA EA	2662
rs73024324^1,2	C,F	--	167743306(+)	`GTCACC/TTTACA`	3	--	us2k¹		4		WA CSA	124
rs146320674^1,2	C	--	167743315(+)	`CATGTA/TCAATA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for XIRP2 (167744997 - 167994997 bp, first 250kb of XIRP2)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for XIRP2 (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
esv2721094	CNV	Deletion	23290073
esv2663157	CNV	Deletion	23128226
esv2721093	CNV	Deletion	23290073
esv2672990	CNV	Deletion	23128226
esv2512957	CNV	Deletion	19546169
esv2390072	CNV	Deletion	18987734
nsv214042	CNV	Insertion	16902084
nsv875377	CNV	Loss	21882294
nsv508177	CNV	Loss	20534489
nsv213355	CNV	Loss	16902084

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing XIRP2

DNA2.0 Custom Variant and Variant Library Synthesis for XIRP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 609778 OMIM disorders: --

1 disease for XIRP2:
About MalaCards

osteochondrosis

1 inferred disease relationship from the University of Copenhagen DISEASES database for XIRP2:

Osteochondrosis

Find genes that share disorders with XIRP2 About GenesLikeMe

Genetic Association Database (GAD): XIRP2
Human Genome Epidemiology (HuGE) Navigator: XIRP2 (3 documents)

Export disorders for XIRP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for XIRP2 gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with XIRP2)

Xin repeats define a novel actin-binding motif. (PubMed id 15454575)^{1, 2, 3} Pacholsky D.... van der Ven P.F.M. (J. Cell Sci. 2004)
Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein. (PubMed id 17046827)^{1, 3, 9} Huang H.-T.... Naya F.J. (J. Biol. Chem. 2006)
SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample. (PubMed id 16205742)^{1, 4} Blasi F....Maestrini E. (Eur. J. Hum. Genet. 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. (PubMed id 12203715)^{1, 3} Sinn H.W....Lin J.J. (Dev. Dyn. 2002)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (Biochem. J. 2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (Mol. Med. 2010)
Network organization of the human autophagy system. (PubMed id 20562859)¹ Behrends C....Harper J.W. (Nature 2010)
Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (PubMed id 20520587)¹ Nielsen D.A....Kreek M.J. (Psychiatr. Genet. 2010)
Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)⁴ Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 129446	HGNC: 14303	AceView: CMYA3	Ensembl:ENSG00000163092	euGenes: HUgn129446
ECgene: XIRP2	H-InvDB: XIRP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for XIRP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for XIRP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for XIRP2 gene:
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GeneCards and IP:
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XIRP2 Gene

Xin Actin-Binding Repeat Containing 2

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XIRP2 Gene

Xin Actin-Binding Repeat Containing 2

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