Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

XIRP2 Gene

protein-coding GIFtS: 47
GCID: GC02P167744

xin actin-binding repeat containing 2

(Previous name: cardiomyopathy associated 3 )
(Previous symbol: CMYA3)

Explore 3 diseases affiliated with
XIRP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Xin Actin-Binding Repeat Containing 2¹ ²		Xeplin³
CMYA3¹ ² ³ ⁵		Xin Actin-Binding Repeat-Containing Protein 2²
Cardiomyopathy Associated 3¹ ²		Xin Repeat Protein 2²
Cardiomyopathy-Associated Protein 3² ³		Beta-Xin¹
Beta-Xin¹		Xeplin³
Myomaxin¹

External Ids:	HGNC: 14303¹	Entrez Gene: 129446²	Ensembl: ENSG00000163092⁷	OMIM: 609778⁵	UniProtKB: A4UGR9³

Export aliases for XIRP2 gene to outside databases

Previous GC identifers: GC02P167469 GC02P159640

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9

Function: Protects actin filaments from depolymerization

Gene Wiki entry for XIRP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the XIRP2 gene promoter:
Bach1 Pax-2 Pax-2a POU6F1 (c2) HNF-1A POU2F1 POU2F1b HNF-1 POU2F1a POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XIRP2 promoter sequence

Search SABiosciences Chromatin IP Primers for XIRP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XIRP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q31.1

XIRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XIRP2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P167744: view genomic region (about GC identifiers)

Start:	167,744,997 bp from pter	End:	168,116,263 bp from pter
Size:	371,267 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9 (See protein sequence)

Recommended Name: Xin actin-binding repeat-containing protein 2

Size: 3374 amino acids; 382300 Da

Subunit: Interacts with ACTN2 (By similarity). Interacts with F-actin

Subcellular location: Cell junction. Note=Colocalizes with actin stress fibers (By similarity)

Miscellaneous: 'Xin' means 'heart' in Chinese

Sequence caution: Sequence=AAH18673.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=AAY24138.1; Type=Erroneous gene model prediction; Sequence=CAD38624.1; Type=Miscellaneous

discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAD89958.1; Type=Miscellaneous

discrepancy; Note=Contaminating sequence; Sequence=CAD91141.2; Type=Miscellaneous discrepancy; Note=Contaminating

sequence;

1 PDB 3D structure from and Proteopedia for XIRP2:

4F14 (3D)

Secondary accessions: A0PJ94 B2BBS0 B2BBS1 B2BBS4 B3KVH0 Q53R52 Q5MJ67 Q702N7 Q86T36 Q86T38 Q86T46

Q86T51 Q86T53 Q86T55 Q86T79 Q86TB6 Q8N1M9 Q8N3R5 Q8TBV6

Alternative splicing: 7 isoforms: A4UGR9-1 A4UGR9-2 A4UGR9-3 A4UGR9-4 A4UGR9-5 A4UGR9-6 A4UGR9-7 (Variant in position: 757:R->G (in dbSNP:rs3749005). Variant in position: 885:V->G (in dbSNP:rs3749006). Variant in position: 905:E->Q (in dbSNP:rs16853344))

Explore the universe of human proteins at neXtProt for XIRP2: NX_A4UGR9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A4UGR9

XIRP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001073278.1 NP_001186072.1 NP_001186073.1 NP_001186074.1 NP_689594.4

ENSEMBL proteins:

ENSP00000386454 ENSP00000386619 ENSP00000386840 ENSP00000387255 ENSP00000386981

ENSP00000386724 ENSP00000415541 ENSP00000295237

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for XIRP2
	GenScript Custom Purified and Recombinant Proteins Services for XIRP2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for XIRP2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030054	cell junction	IEA	--

XIRP2 for ontologies About GeneDecksing

XIRP2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for XIRP2
	GenScript Custom Superior Antibodies Services for XIRP2
	Novus Biologicals XIRP2 Antibodies
	Search for Antibodies for XIRP2 at Abcam
	Uscn Antibodies for XIRP2
	Search ThermoFisher Antibodies for XIRP2

Assay Products for XIRP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for XIRP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for XIRP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

XIRP2 for domains About GeneDecksing

1 InterPro domain/family:

IPR012510 Actin-binding_Xin_repeat

Graphical View of Domain Structure for InterPro Entry A4UGR9

ProtoNet protein and cluster: A4UGR9

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9

Domain: Xin repeats bind F-actin

Similarity: Belongs to the Xin family

Similarity: Contains 28 Xin repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9

Function: Protects actin filaments from depolymerization

miRNA Products:		OriGene 3'-UTR Clone: XIRP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XIRP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate XIRP2
		SwitchGear 3'UTR luciferase reporter plasmid: XIRP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XIRP2 (see all 7) OriGene shRNA RFP: XIRP2 OriGene siRNA: XIRP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XIRP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for XIRP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XIRP2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XIRP2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): XIRP2 (NM_001079810)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XIRP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XIRP2
		Search LifeMap BioReagents cell lines for XIRP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--

XIRP2 for ontologies About GeneDecksing

Animal Models:
10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Xirp2):

behavior/neurological	cardiovascular system	cellular	growth/size	homeostasis/metabolism
integument	liver/biliary system	mortality/aging	muscle	normal

XIRP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for XIRP2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for XIRP2 (A4UGR9³ ENSP00000386840⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NSMAF	Q92636³, ENSP00000411012⁴	I2D: score=3 STRING: ENSP00000411012

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030036	actin cytoskeleton organization	IEA	--

XIRP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for XIRP2
Search CenterWatch for drugs/clinical trials and news about XIRP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for XIRP2 gene (5 alternative transcripts):

NM_001079810.3 NM_001199143.1 NM_001199144.1 NM_001199145.1 NM_152381.5

Unigene Cluster for XIRP2:

Xin actin-binding repeat containing 2

Hs.73680 [show with all ESTs]

Unigene Representative Sequence: NM_152381

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409043 ENST00000409728(uc010fpn.3) ENST00000409195(uc002udx.3 uc010fpo.3)

ENST00000409273(uc010fpq.3) ENST00000409605(uc010fpr.3) ENST00000409756

ENST00000420519 ENST00000295237(uc002udy.3)

miRNA Products:		OriGene 3'-UTR Clone: XIRP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XIRP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate XIRP2
		SwitchGear 3'UTR luciferase reporter plasmid: XIRP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XIRP2 (see all 7) OriGene shRNA RFP: XIRP2 OriGene siRNA: XIRP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XIRP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XIRP2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XIRP2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): XIRP2 (NM_001079810)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XIRP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XIRP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat XIRP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XIRP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XIRP2

Additional cDNA sequence:

AJ626901.1 AK056582.1 AK092683.1 AK096430.1 AK096907.1 AK097519.1 AK122889.1 AK123963.1

AK125495.1 AL831970.2 AL831985.1 AL832011.1 AL832331.1 AL832336.1 AL832360.1 AL832375.1

AL832382.1 AL832452.2 AL833291.2 AY820969.1 BC016370.1 BC018673.1 BC022446.1 BC022887.1

BC022888.1 BC070143.1 BC107799.1 BX647448.1 BX647645.1 BX647844.1 BX647845.1 BX647848.1

EF119711.1 EF119717.1 EF119718.1 EF119719.1 EF119720.1 EF119721.1 EF119722.1

8 DOTS entries:

DT.101984484 DT.213707 DT.95343202 DT.95185473 DT.100795194 DT.120951509 DT.100795191 DT.92439424

24/200 AceView cDNA sequences (see all 200):

BQ954214 AL832011 AJ626901 BX647645 AA111946 BX500581 AL596757 BC022887

BC022888 AI803678 AK096430 C05081 F32854 AL832336 Z28678 AK096907

BC070143 AW755252 F28773 AA195845 AL832452 BX647448 BC022446 AK122889

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

XIRP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

XIRP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Heart

Right Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See XIRP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XIRP2

SOURCE GeneReport for Unigene cluster: Hs.73680

SABiosciences Custom PCR Arrays for XIRP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XIRP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat XIRP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XIRP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XIRP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for XIRP2 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	XIRP2⁶	--	49(a)	1 ↔ 1	GL343214.1(235083-251381)
zebrafish (Danio rerio)	Actinopterygii	xirp2a¹	xin actin-binding repeat containing 2a	54.02(n) 44.52(a)		559746 XM_683113.4 XP_688205.4

ENSEMBL Gene Tree for XIRP2 (if available)
TreeFam Gene Tree for XIRP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for XIRP2 gene

XIRP1²

XIRP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137994034^1,2		--	167743024(+)	`TGACTC/GAAAGG`	3	--	us2k¹		0	--	--	--	--
rs114833261^1,2		--	167743038(+)	`GCCTCA/GTTTCA`	3	--	us2k¹		1		WA	118
rs182417926^1,2		--	167743104(+)	`CCCATC/TGCAAC`	3	--	us2k¹		0	--	--	--	--
rs186639288^1,2		--	167743216(+)	`TCATAA/CTTACC`	3	--	us2k¹		0	--	--	--	--
rs142057486^1,2		--	167743262(+)	`TGCCAC/TAACTT`	3	--	us2k¹		0	--	--	--	--
rs115631329^1,2		--	167743292(+)	`TTTATA/GTCTAA`	3	--	us2k¹		1		WA	118
rs10497303^1,2	C,F,H,	--	167743294(+)	`TATATC/GTAACC`	3	--	us2k¹		28		NS NA EA	2662
rs73024324^1,2	C,F,	--	167743306(+)	`GTCACC/TTTACA`	3	--	us2k¹		4		WA CSA	124
rs146320674^1,2		--	167743315(+)	`CATGTA/TCAATA`	3	--	us2k¹		0	--	--	--	--
rs113240468^1,2	F,	--	167743324(+)	`TATTCC/G/TAGCTG`	3	--	us2k¹		2		CSA	4

HapMap Linkage Disequilibrium report for XIRP2 (167744997 - 167994997 bp, first 250kb of XIRP2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for XIRP2
4 CNVs: 90118 35752 44003 98050
1 Indel: 12107

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XIRP2

DNA2.0 Custom Variant and Variant Library Synthesis for XIRP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

XIRP2 for disorders           About GeneDecksing

OMIM gene information: 609778    OMIM disorders: --

3 diseases for XIRP2:    About MalaCards

cardiomyopathy heroin dependence osteochondrosis

1 disease from the University of Copenhagen DISEASES database for XIRP2:

Osteochondrosis

Human Genome Epidemiology (HuGE) Navigator: XIRP2 (3 documents)

Export disorders for XIRP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for XIRP2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with XIRP2)

Utopia: connect your pdf to the dynamic
world of online information

Xin repeats define a novel actin-binding motif. (PubMed id 15454575)^{1, 2, 3} Pacholsky D....van der Ven P.F. (2004)
Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein. (PubMed id 17046827)^{1, 3, 9} Huang H.-T.... Naya F.J. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. (PubMed id 12203715)^{1, 3} Sinn H.W....Lin J.J. (2002)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Network organization of the human autophagy system. (PubMed id 20562859)¹ Behrends C....Harper J.W. (2010)
Genome-wide association study identifies genes that m ay contribute to risk for developing heroin addiction. (PubMed id 20520587)¹ Nielsen D.A....Kreek M.J. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample. (PubMed id 16205742)¹ Blasi F....Maestrini E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 129446	HGNC: 14303	AceView: CMYA3	Ensembl:ENSG00000163092	euGenes: HUgn129446
ECgene: XIRP2	H-InvDB: XIRP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for XIRP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for XIRP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for XIRP2 gene:
Search GeneIP for patents involving XIRP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for XIRP2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XIRP2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XIRP2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for XIRP2		OriGene 3'-UTR Clone for XIRP2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XIRP2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XIRP2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for XIRP2		OriGene Custom Protein Services for XIRP2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XIRP2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XIRP2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XIRP2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XIRP2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XIRP2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XIRP2

	GenScript Custom Purified and Recombinant Proteins Services for XIRP2		GenScript cDNA clones with any tag delivered in your preferred vector for XIRP2
	GenScript Custom Assay Services for XIRP2		GenScript Custom Superior Antibodies Services for XIRP2
	GenScript Custom overexpressing Cell Line Services for XIRP2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in XIRP2 promoter
	Search Chromatin IP Primers for XIRP2
	RT² qPCR Primer Assay in human, mouse, rat XIRP2
	Search GNC Networks for XIRP2
	SABiosciences Custom PCR Arrays for XIRP2

Search Tocris compounds for XIRP2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	XIRP2 antibodies

	Search for Antibodies for XIRP2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for XIRP2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

XIRP2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for XIRP2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP2

	SwitchGear 3'UTR luciferase reporter plasmids for XIRP2
	SwitchGear Promoter luciferase reporter plasmids for XIRP2

Search ThermoFisher Antibodies for XIRP2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes XIRP2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

XIRP2 Gene

xin actin-binding repeat containing 2

Aliases
for XIRP2 gene

Summaries
for XIRP2 gene

Genomic Views
for XIRP2 gene

Proteins
for XIRP2 gene

Protein Domains /
Families
for XIRP2 gene

Function
for XIRP2 gene

Pathways & Interactions
for XIRP2 gene

Drugs & Compounds
for XIRP2 gene

Transcripts
for XIRP2 gene

Expression
for XIRP2 gene

Orthologs
for XIRP2 gene

Paralogs
for XIRP2 gene

Genomic Variants
for XIRP2 gene

Disorders / Diseases
for XIRP2 gene

Publications
for XIRP2 gene

External Searches for XIRP2 gene

Genome Databases showing XIRP2 gene

Other Databases showing XIRP2 gene

Specialized Databases showing XIRP2 gene

Intellectual Property
for XIRP2 gene

Products
for XIRP2 gene

View Random Gene

Advanced Search

Export list of displayed genes

XIRP2 Gene

xin actin-binding repeat containing 2

Aliasesfor XIRP2 gene

Summariesfor XIRP2 gene

Genomic Viewsfor XIRP2 gene

Proteinsfor XIRP2 gene

Protein Domains /Familiesfor XIRP2 gene

Functionfor XIRP2 gene

Pathways & Interactionsfor XIRP2 gene

Drugs & Compoundsfor XIRP2 gene

Transcriptsfor XIRP2 gene

Expression for XIRP2 gene

Orthologsfor XIRP2 gene

Paralogsfor XIRP2 gene

Genomic Variantsfor XIRP2 gene

Disorders / Diseasesfor XIRP2 gene

Publicationsfor XIRP2 gene

External Searches for XIRP2 gene

Genome Databases showing XIRP2 gene

Other Databases showing XIRP2 gene

Specialized Databases showing XIRP2 gene

Intellectual Propertyfor XIRP2 gene

Productsfor XIRP2 gene

View Random Gene

Aliases
for XIRP2 gene

Summaries
for XIRP2 gene

Genomic Views
for XIRP2 gene

Proteins
for XIRP2 gene

Protein Domains /
Families
for XIRP2 gene

Function
for XIRP2 gene

Pathways & Interactions
for XIRP2 gene

Drugs & Compounds
for XIRP2 gene

Transcripts
for XIRP2 gene

Expression
for XIRP2 gene

Orthologs
for XIRP2 gene

Paralogs
for XIRP2 gene

Genomic Variants
for XIRP2 gene

Disorders / Diseases
for XIRP2 gene

Publications
for XIRP2 gene

Intellectual Property
for XIRP2 gene

Products
for XIRP2 gene