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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

XIRP2 Gene

protein-coding GIFtS: 48
GCID: GC02P167744

Xin Actin-Binding Repeat Containing 2

(Previous name: cardiomyopathy associated 3)
(Previous symbol: CMYA3)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Xin Actin-Binding Repeat Containing 2¹ ²		xeplin²
CMYA3¹ ² ³ ⁵		Xin Actin-Binding Repeat-Containing Protein 2²
Cardiomyopathy Associated 3¹ ²		Xin Repeat Protein 2²
Cardiomyopathy-Associated Protein 3² ³		Beta-xin³
beta-xin²		Xeplin³
myomaxin²

External Ids:	HGNC: 14303¹	Entrez Gene: 129446²	Ensembl: ENSG00000163092⁷	OMIM: 609778⁵	UniProtKB: A4UGR9³

Export aliases for XIRP2 gene to outside databases

Previous GC identifers: GC02P167469 GC02P159640

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for XIRP2 Gene:

XIRP2 (xin actin-binding repeat containing 2) is a protein-coding gene. Diseases associated with XIRP2 include osteochondrosis, and heroin dependence. GO annotations related to this gene include actin binding. An important paralog of this gene is XIRP1.

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9

Function: Protects actin filaments from depolymerization

Gene Wiki entry for XIRP2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.2 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the XIRP2 gene promoter:
Bach1 Pax-2 Pax-2a POU6F1 (c2) HNF-1A POU2F1 POU2F1b HNF-1 POU2F1a POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XIRP2 promoter sequence

Search SABiosciences Chromatin IP Primers for XIRP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XIRP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q31.1

XIRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XIRP2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P167744: view genomic region (about GC identifiers)

Start:	167,744,997 bp from pter	End:	168,116,263 bp from pter
Size:	371,267 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9 (See protein sequence)

Recommended Name: Xin actin-binding repeat-containing protein 2

Size: 3374 amino acids; 382300 Da

Subunit: Interacts with ACTN2 (By similarity). Interacts with F-actin

Subcellular location: Cell junction. Note=Colocalizes with actin stress fibers (By similarity)

Miscellaneous: 'Xin' means 'heart' in Chinese

Sequence caution: Sequence=AAH18673.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence; Sequence=AAY24138.1; Type=Erroneous gene model prediction; Sequence=CAD38624.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAD89958.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=CAD91141.2; Type=Miscellaneous discrepancy;

Note=Contaminating sequence;

1 PDB 3D structure from and Proteopedia for XIRP2:

4F14 (3D)

Secondary accessions: A0PJ94 B2BBS0 B2BBS1 B2BBS4 B3KVH0 Q53R52 Q5MJ67 Q702N7 Q86T36 Q86T38

Q86T46 Q86T51 Q86T53 Q86T55 Q86T79 Q86TB6 Q8N1M9 Q8N3R5 Q8TBV6

Alternative splicing: 7 isoforms: A4UGR9-1 A4UGR9-2 A4UGR9-3 A4UGR9-4 A4UGR9-5 A4UGR9-6 A4UGR9-7 (Variant in position: 757:R->G (in dbSNP:rs3749005). Variant in position: 885:V->G (in dbSNP:rs3749006). Variant in position: 905:E->Q (in dbSNP:rs16853344))

Explore the universe of human proteins at neXtProt for XIRP2: NX_A4UGR9

Explore proteomics data for XIRP2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_A4UGR9

XIRP2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (5 alternative transcripts):

NP_001073278.1 NP_001186072.1 NP_001186073.1 NP_001186074.1 NP_689594.4

ENSEMBL proteins:

ENSP00000386454 ENSP00000386619 ENSP00000386840 ENSP00000387255 ENSP00000386981

ENSP00000386724 ENSP00000415541 ENSP00000295237

Human Recombinant Protein Products for XIRP2:

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	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for XIRP2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030018	Z disc	--	--
GO:0030054	cell junction	IEA	--

XIRP2 for ontologies About GeneDecksing

XIRP2 Antibody Products:

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	Novus Biologicals XIRP2 Antibodies
	Abcam antibodies for XIRP2
	Cloud-Clone Corp. Antibodies for XIRP2
	Search ThermoFisher Antibodies for XIRP2
	LSBio Antibodies in human, mouse, rat for XIRP2

Assay Products for XIRP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for XIRP2
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	GenScript Custom Assay Services for XIRP2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for XIRP2 Cloud-Clone Corp. CLIAs for XIRP2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR012510 Actin-binding_Xin_repeat

Graphical View of Domain Structure for InterPro Entry A4UGR9

ProtoNet protein and cluster: A4UGR9

UniProtKB/Swiss-Prot: XIRP2_HUMAN, A4UGR9

Domain: Xin repeats bind F-actin

Similarity: Belongs to the Xin family

Similarity: Contains 28 Xin repeats

XIRP2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: XIRP2_HUMAN, A4UGR9

Function: Protects actin filaments from depolymerization

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	--	--
GO:0051393	alpha-actinin binding	--	--

XIRP2 for ontologies About GeneDecksing

Phenotypes:
10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Xirp2):

behavior/neurological	cardiovascular system	cellular	growth/size	homeostasis/metabolism
integument	liver/biliary system	mortality/aging	muscle	normal

XIRP2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for XIRP2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XIRP2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XIRP2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XIRP2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XIRP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate XIRP2
		SwitchGear 3'UTR luciferase reporter plasmid: XIRP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for XIRP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XIRP2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for XIRP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for XIRP2 (see all 8) OriGene ORF clones in mouse, rat for XIRP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): XIRP2 (NM_001079810)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XIRP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XIRP2
		Search LifeMap BioReagents cell lines for XIRP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for XIRP2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for XIRP2 (A4UGR9³ ENSP00000386840⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NSMAF	Q92636³, ENSP00000411012⁴	I2D: score=3 STRING: ENSP00000411012

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003281	ventricular septum development	--	--
GO:0030036	actin cytoskeleton organization	IEA	--
GO:0045216	cell-cell junction organization	--	--
GO:0055008	cardiac muscle tissue morphogenesis	--	--

XIRP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for XIRP2

Search CenterWatch for drugs/clinical trials and news about XIRP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for XIRP2 gene (5 alternative transcripts):

NM_001079810.3 NM_001199143.1 NM_001199144.1 NM_001199145.1 NM_152381.5

Unigene Cluster for XIRP2:

Xin actin-binding repeat containing 2

Hs.73680 [show with all ESTs]

Unigene Representative Sequence: NM_152381

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409043 ENST00000409728(uc010fpn.3) ENST00000409195(uc002udx.3 uc010fpo.3)

ENST00000409273(uc010fpq.3) ENST00000409605(uc010fpr.3) ENST00000409756

ENST00000420519 ENST00000295237(uc002udy.3)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XIRP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate XIRP2
		SwitchGear 3'UTR luciferase reporter plasmid: XIRP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for XIRP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XIRP2

Clone Products:		OriGene clones in human, mouse for XIRP2 (see all 8) OriGene ORF clones in mouse, rat for XIRP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): XIRP2 (NM_001079810)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XIRP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for XIRP2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat XIRP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XIRP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XIRP2

Additional mRNA sequence:

AJ626901.1 AK056582.1 AK092683.1 AK096430.1 AK096907.1 AK097519.1 AK122889.1 AK123963.1

AK125495.1 AL831970.2 AL831985.1 AL832011.1 AL832331.1 AL832336.1 AL832360.1 AL832375.1

AL832382.1 AL832452.2 AL833291.2 AY820969.1 BC016370.1 BC018673.1 BC022446.1 BC022887.1

BC022888.1 BC070143.1 BC107799.1 BX647448.1 BX647645.1 BX647844.1 BX647845.1 BX647848.1

EF119711.1 EF119717.1 EF119718.1 EF119719.1 EF119720.1 EF119721.1 EF119722.1

8 DOTS entries:

DT.101984484 DT.213707 DT.95343202 DT.95185473 DT.100795194 DT.120951509 DT.100795191 DT.92439424

24/200 AceView cDNA sequences (see all 200):

AJ626901 AL832452 BC022446 BX647448 AA195845 AW755252 BC070143 F28773

AK096907 Z28678 AA111946 BX500581 BX647645 AL596757 BC022888 AI803678

BC022887 AL832336 AK096430 F32854 C05081 F21569 AK122889 AK056582

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

XIRP2 expression in normal human tissues (normalized intensities) XIRP2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

XIRP2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/3 selected tissues (see all 3) fully expand


Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
vastus lateralis

Endothelium (Cardiovascular System)
Endothelial-like cells ( Derivation and purification of endothelial precursor cells...

Adipose (Muscoskeletal System)
Interscapular Brown Adipose Depot

See XIRP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XIRP2

SOURCE GeneReport for Unigene cluster: Hs.73680

SABiosciences Custom PCR Arrays for XIRP2

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat XIRP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XIRP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XIRP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for XIRP2 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Xirp2^{1 , 5}	xin actin-binding repeat containing 2^{1, 5}	80.1(n)¹ 72.99(a)¹		2 (39.31 cM)⁵ 241431¹ NM_001083919.1¹ NP_001077388.1¹ 67446002⁵
lizard (Anolis carolinensis)	Reptilia	XIRP2⁶	xin actin-binding repeat containing 2	48(a)	1 ↔ 1	GL343214.1(229056-439293)
zebrafish (Danio rerio)	Actinopterygii	xirp2a¹	xin actin-binding repeat containing 2a	54.02(n) 44.52(a)		559746 XM_683113.4 XP_688205.4

ENSEMBL Gene Tree for XIRP2 (if available)
TreeFam Gene Tree for XIRP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for XIRP2 gene

XIRP1²

XIRP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140208720^1,2	C	untested¹	167760256(+)	`ACCAGA/GGAATA`	6	R	syn¹		0	--	--	--	--
rs137994034^1,2		--	167743024(+)	`TGACTC/GAAAGG`	3	--	us2k¹		0	--	--	--	--
rs114833261^1,2	C,F	--	167743038(+)	`GCCTCA/GTTTCA`	3	--	us2k¹		1		WA	118
rs182417926^1,2		--	167743104(+)	`CCCATC/TGCAAC`	3	--	us2k¹		0	--	--	--	--
rs186639288^1,2		--	167743216(+)	`TCATAA/CTTACC`	3	--	us2k¹		0	--	--	--	--
rs142057486^1,2	C	--	167743262(+)	`TGCCAC/TAACTT`	3	--	us2k¹		0	--	--	--	--
rs115631329^1,2	F	--	167743292(+)	`TTTATA/GTCTAA`	3	--	us2k¹		1		WA	118
rs10497303^1,2	C,F,H	--	167743294(+)	`TATATC/GTAACC`	3	--	us2k¹		28		NS NA EA	2662
rs73024324^1,2	C,F	--	167743306(+)	`GTCACC/TTTACA`	3	--	us2k¹		4		WA CSA	124
rs146320674^1,2	C	--	167743315(+)	`CATGTA/TCAATA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for XIRP2 (167744997 - 167994997 bp, first 250kb of XIRP2)

Structural Variations
Database of Genomic Variants (DGV) 10/14 variations for XIRP2 (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
esv2721094	CNV	Deletion	23290073
esv2663157	CNV	Deletion	23128226
esv2721093	CNV	Deletion	23290073
esv2672990	CNV	Deletion	23128226
esv2512957	CNV	Deletion	19546169
esv2390072	CNV	Deletion	18987734
nsv214042	CNV	Insertion	16902084
nsv875377	CNV	Loss	21882294
nsv508177	CNV	Loss	20534489
nsv213355	CNV	Loss	16902084

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing XIRP2

DNA2.0 Custom Variant and Variant Library Synthesis for XIRP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 609778 OMIM disorders: --

2 diseases for XIRP2: About MalaCards

osteochondrosis heroin dependence

1 disease from the University of Copenhagen DISEASES database for XIRP2:

Osteochondrosis

XIRP2 for disorders About GeneDecksing

Genetic Association Database (GAD): XIRP2
Human Genome Epidemiology (HuGE) Navigator: XIRP2 (3 documents)

Export disorders for XIRP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for XIRP2 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with XIRP2)

Utopia: connect your pdf to the dynamic
world of online information

Xin repeats define a novel actin-binding motif. (PubMed id 15454575)^{1, 2, 3} Pacholsky D....van der Ven P.F. (2004)
Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein. (PubMed id 17046827)^{1, 3, 9} Huang H.-T.... Naya F.J. (2006)
SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample. (PubMed id 16205742)^{1, 4} Blasi F....Maestrini E. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. (PubMed id 12203715)^{1, 3} Sinn H.W....Lin J.J. (2002)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Network organization of the human autophagy system. (PubMed id 20562859)¹ Behrends C....Harper J.W. (2010)
Genome-wide association study identifies genes that m ay contribute to risk for developing heroin addiction. (PubMed id 20520587)¹ Nielsen D.A....Kreek M.J. (2010)
Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)⁴ Newton-Cheh C....Larson M.G. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 129446	HGNC: 14303	AceView: CMYA3	Ensembl:ENSG00000163092	euGenes: HUgn129446
ECgene: XIRP2	H-InvDB: XIRP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for XIRP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for XIRP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for XIRP2 gene:
Search GeneIP for patents involving XIRP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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XIRP2 Gene

Xin Actin-Binding Repeat Containing 2

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XIRP2 Gene

Xin Actin-Binding Repeat Containing 2

Aliasesfor XIRP2 gene

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Protein Domains /Familiesfor XIRP2 gene

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Expression for XIRP2 gene

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External Searches for XIRP2 gene

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Expression
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Intellectual Property
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