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Aliases & Descriptions for XIRP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CMYA1 2, 3 | | DKFZp451D042 1, 2 | | DKFZp779C1255 2 | | DKFZp779C1947 2 | | XIN 3 | | Xin 1, 2 |
| | | Descriptions |
|---|
| Cardiomyopathy-associated protein 1 3 | | cardiomyopathy associated 1 1, 2 | | xin actin-binding repeat containing 1 2 |
|
| | Search outside databases for aliases for XIRP1 gene |
Summaries for XIRP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8Function: Protects actin filaments from depolymerization |
Genomic Location for XIRP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22.2 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p21.33XIRP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M039200:
(about GC identifiers)
Start:
|
39,199,705 bp from pter |
End:
|
39,209,091 bp from pter |
Size:
|
9,387 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for XIRP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8 (See
protein sequence)Recommended Name: Xin actin-binding repeat-containing protein 1 Size: 1843 amino acids; 198561 Da
Subunit: Interacts with CTNNB1 (By similarity). Interacts with F-actin, FLNC and VASP
Subcellular location: Cell junction. Note=Colocalizes with actin stress fibers
Miscellaneous: 'Xin' means 'heart' in Chinese
Sequence caution: Sequence=CAC81057.1; Type=Frameshift; Positions=1594;
Secondary accessions: A0JP25 A4QPE2 Q68DF2 Q6ZTR3 Q702N9 Q8IVN7 Q8N1N3 Q8N904 Q8TCG7Alternative splicing: 3 isoforms: Q702N8-1 Q702N8-2 Q702N8-3 REFSEQ proteins: NP_919269.2
ENSEMBL proteins: ENSP00000379550 ENSP00000343140
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005916 | fascia adherens |
IEA | -- | | GO:0030054 | cell junction |
IEA | -- | About this table
Antibodies for XIRP1: Assays for XIRP1: | Protein
Domains/ Families for XIRP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q702N8
ProtoNet protein and cluster: Q702N8 1 Blocks protein family: IPB012510 Actin Binding Sixteen Amino Acid
UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8Domain: Xin repeats bind F-actinSimilarity: Belongs to the Xin familySimilarity: Contains 17 Xin repeats | Gene Function for XIRP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_093522
Applied Biosystems Silencer® siRNAs for XIRP1
Sigma-Aldrich siRNA for XIRP1  Sigma-Aldrich shRNA for XIRP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_194293                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_194293                                  untagged cDNA clone in CMV expression vector: NM_194293 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_194293
UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8Function: Protects actin filaments from depolymerization2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Xirp1):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- | About this table | Pathways & Interactions for XIRP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for XIRP1 (ENSP000003431403) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008285 | negative regulation of cell proliferation |
IEA | -- | | GO:0030036 | actin cytoskeleton organization |
IEA | -- | | GO:0042391 | regulation of membrane potential |
IEA | -- | | GO:0045214 | sarcomere organization |
IEA | -- | | GO:0055013 | cardiac muscle cell development |
IEA | -- | About this table
|
Drugs & Compounds for XIRP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for XIRP1
|
Transcripts for XIRP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_093522
Sigma-Aldrich siRNA for XIRP1  Sigma-Aldrich shRNA for XIRP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_194293 REFSEQ mRNAs for XIRP1 gene: NM_194293.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_194293               OriGene GFP tagged cDNA clone in CMV expression vector: NM_194293                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_194293                                  untagged cDNA clone in CMV expression vector: NM_194293  Additional cDNA sequence: AJ271461.1 AJ626899.1 AJ626900.1 AK095941.1 AK096421.1 AK122723.1 AK126299.1 AL713648.1 AL831956.1 AL832020.1 AL832459.1 AY375160.1 BC127119.1 BC139782.1 BX648565.1 CR749430.1 5 DOTS entries: DT.95345262 DT.453185 DT.100750081 DT.100019592 DT.120911400 24/53 AceView cDNA sequences (see all 53
):AI239637 BF839758 N74291 AJ626900 AK096421 AK126299 F36825 AL831956 AK095941 NM_194293 AY375160 AJ626899 BX116988 AW755250 BF835132 F24194 BF507675 BX648565 AL832020 AL713648 AK122723 BX499880 AI185610 AJ706929 Unigene Cluster for XIRP1: Xin actin-binding repeat containing 1 Hs.447868 [show with all ESTs]Unigene Representative Sequence: AJ626900
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for XIRP1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | |
| SP1: | |   | |   | |   | |   | |
| SP2: | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for XIRP1
2 Ensembl transcripts including schematic representations: ENST00000396251
ENST00000340369
|
Expression for XIRP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| XIRP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for XIRP1
1 / 2 4 probe-sets matching XIRP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACTGTCCCCC
SOURCE GeneReport for Unigene cluster: Hs.447868 UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8Tissue specificity: Isoform A, isoform B and isoform C are expressed in heart |
Orthologs for XIRP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XIRP1 gene from 4 species
About this table Species with no ortholog for XIRP1
ENSEMBL Gene Tree for XIRP1 | Paralogs for XIRP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for XIRP1 gene
- XIRP22
|
SNPs/Variants for XIRP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for XIRP1 (up to first 250kb)
|
Disorders & Mutations for XIRP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609777
|
Medical News for XIRP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for XIRP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for XIRP1 gene (see all 11
):- Xin repeats define a novel actin-binding motif. (PubMed id 15454575)1, 2, 3, 4 Pacholsky D....van der Ven P.F. (2004)
- Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP. (PubMed id 16631741)1, 3, 4 van der Ven P.F....Furst D.O. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. (PubMed id 12203715)2, 3 Sinn H.W....Lin J.J. (2002)
- Differential involvement of sarcomeric proteins in myofibrillar myopathies: a morphological and immunohistochemical study. (PubMed id 19151983)3 Claeys K.G....FA1rst D.O. (2009)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Requirement of a novel gene, Xin, in cardiac morphogenesis. (PubMed id 10021346)3 Wang D.Z....Lin J.J. (1999)
|
Search for XIRP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing XIRP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing XIRP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XIRP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for XIRP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for XIRP1:

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| | | | Search Tocris compounds for XIRP1 |
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Incremental update: 13 Oct 2009
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