Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



XIRP1 Gene

protein-coding   GIFtS: 49
GCID: GC03M039200

Xin Actin-Binding Repeat Containing 1

(Previous name: cardiomyopathy associated 1)
(Previous symbol: CMYA1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Xin Actin-Binding Repeat Containing 11 2     XIN3 5
CMYA11 2 3 5     Xin2
Cardiomyopathy Associated 11 2     Xin Actin-Binding Repeat-Containing Protein 12
Cardiomyopathy-Associated Protein 12 3     

External Ids:    HGNC: 143011   Entrez Gene: 1659042   Ensembl: ENSG000001683347   OMIM: 6097775   UniProtKB: Q702N83   

Export aliases for XIRP1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for XIRP1 Gene:
XIRP1 (xin actin-binding repeat containing 1) is a protein-coding gene. Diseases associated with XIRP1 include myofibrillar myopathy, and myopathy. GO annotations related to this gene include actin binding. An important paralog of this gene is XIRP2.

UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8
Function: Protects actin filaments from depolymerization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the XIRP1 gene promoter:
         CHOP-10   MyoD   aMEF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXIRP1 promoter sequence
   Search Chromatin IP Primers for XIRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XIRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21.33

XIRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XIRP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M039200:  view genomic region     (about GC identifiers)

Start:
39,224,701 bp from pter      End:
39,234,087 bp from pter
Size:
9,387 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8 (See protein sequence)
Recommended Name: Xin actin-binding repeat-containing protein 1  
Size: 1843 amino acids; 198561 Da
Subunit: Interacts with CTNNB1 (By similarity). Interacts with F-actin, FLNC and VASP
Miscellaneous: 'Xin' means 'heart' in Chinese
Sequence caution: Sequence=BAC86519.1; Type=Erroneous initiation; Sequence=CAC81057.1; Type=Frameshift;
Positions=1594; Sequence=CAD28459.1; Type=Erroneous initiation;
Secondary accessions: A0JP25 A4QPE2 Q68DF2 Q6ZTR3 Q702N9 Q8IVN7 Q8N1N3 Q8N904 Q8TCG7
Alternative splicing: 3 isoforms:  Q702N8-1   Q702N8-2   Q702N8-3   

Explore the universe of human proteins at neXtProt for XIRP1: NX_Q702N8

Explore proteomics data for XIRP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See XIRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185550.1  NP_919269.2  

    ENSEMBL proteins: 
     ENSP00000379550   ENSP00000343140   ENSP00000391645  

    XIRP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for XIRP1
    GenScript Custom Purified and Recombinant Proteins Services for XIRP1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XIRP1

    XIRP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for XIRP1
    OriGene Custom Antibody Services for XIRP1
    Novus Biologicals XIRP1 Antibodies
    Abcam antibodies for XIRP1
    Cloud-Clone Corp. Antibodies for XIRP1
    Search ThermoFisher Antibodies for XIRP1
    LSBio Antibodies in human, mouse, rat for XIRP1

    XIRP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for XIRP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for XIRP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for XIRP1
    Cloud-Clone Corp. CLIAs for XIRP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR012510 Actin-binding_Xin_repeat

    Graphical View of Domain Structure for InterPro Entry Q702N8

    ProtoNet protein and cluster: Q702N8

    1 Blocks protein domain: IPB012510 Actin Binding Sixteen Amino Acid

    UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8
    Domain: Xin repeats bind F-actin
    Similarity: Belongs to the Xin family
    Similarity: Contains 17 Xin repeats


    XIRP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XIRP1_HUMAN, Q702N8
    Function: Protects actin filaments from depolymerization

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    XIRP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for XIRP1:
     Increased cell number in G2M,  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Xirp1):
     cardiovascular system  growth/size/body  muscle 

    XIRP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for XIRP1: Xirp1tm1Dofr Xirp1tm1Jl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XIRP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for XIRP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XIRP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XIRP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target XIRP1:
    hsa-mir-335-5p (MIRT017984)

    Block miRNA regulation of human, mouse, rat XIRP1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate XIRP1:
    hsa-miR-3678-3p hsa-miR-133a hsa-miR-342-5p hsa-miR-133b hsa-miR-759 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidXIRP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for XIRP1
    Predesigned siRNA for gene silencing in human, mouse, rat XIRP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for XIRP1

    Clone
    Products:
         
    OriGene clones in human, mouse for XIRP1 (see all 8)
    OriGene ORF clones in mouse, rat for XIRP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): XIRP1 (NM_194293)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XIRP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for XIRP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for XIRP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    XIRP1_HUMAN, Q702N8: Cell junction. Note=Colocalizes with actin stress fibers
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    nucleus3
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005913cell-cell adherens junction ----
    GO:0005916fascia adherens IEA--
    GO:0014704intercalated disc ----
    GO:0030054cell junction ----

    XIRP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XIRP1
    Interactions:

        Search GeneGlobe Interaction Network for XIRP1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for XIRP1 (Q702N83 ENSP000003431404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0030036actin cytoskeleton organization ----
    GO:0042391regulation of membrane potential IEA--
    GO:0045214sarcomere organization IEA--
    GO:0055013cardiac muscle cell development IEA--

    XIRP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XIRP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for XIRP1 gene (2 alternative transcripts): 
    NM_001198621.1  NM_194293.2  

    Unigene Cluster for XIRP1:

    Xin actin-binding repeat containing 1
    Hs.447868  [show with all ESTs]
    Unigene Representative Sequence: AJ626900
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396251(uc003cji.3 uc003cjj.3) ENST00000340369(uc003cjk.2)
    ENST00000421646
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat XIRP1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate XIRP1:
    hsa-miR-3678-3p hsa-miR-133a hsa-miR-342-5p hsa-miR-133b hsa-miR-759 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidXIRP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for XIRP1
    Predesigned siRNA for gene silencing in human, mouse, rat XIRP1
    Clone
    Products:
         
    OriGene clones in human, mouse for XIRP1 (see all 8)
    OriGene ORF clones in mouse, rat for XIRP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): XIRP1 (NM_194293)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XIRP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for XIRP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XIRP1
      QuantiTect SYBR Green Assays in human, mouse, rat XIRP1
      QuantiFast Probe-based Assays in human, mouse, rat XIRP1

    Additional mRNA sequence: 

    AJ271461.1 AJ626899.1 AJ626900.1 AK095941.1 AK096421.1 AK126299.1 AL713648.1 AY375160.1 
    BC127119.1 BC139782.1 BX648565.1 CR749430.1 

    5 DOTS entries:

    DT.95345262  DT.453185  DT.100750081  DT.100019592  DT.120911400 

    Selected AceView cDNA sequences (see all 53):

    AK095941 AL831956 BX116988 F36825 AK126299 AJ626899 BF839758 NM_194293 
    AJ626900 AW755250 N74291 AI239637 AY375160 AK096421 BF507675 AL713648 
    AL832459 AL596801 CR749430 F25858 AK122723 BX648565 AJ706929 BX499880 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for XIRP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               
    SP3:                        


    ECgene alternative splicing isoforms for XIRP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    XIRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTCCCCC
    XIRP1 Expression
    About this image


    XIRP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells
     
     Skeletal Muscle (Muscoskeletal System)
    XIRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XIRP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447868

    UniProtKB/Swiss-Prot: XIRP1_HUMAN, Q702N8
    Tissue specificity: Isoform A, isoform B and isoform C are expressed in heart

        Custom PCR Arrays for XIRP1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for XIRP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XIRP1
    QuantiTect SYBR Green Assays in human, mouse, rat XIRP1
    QuantiFast Probe-based Assays in human, mouse, rat XIRP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for XIRP1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xirp11 , 5 xin actin-binding repeat containing 11, 5 80.36(n)1
    78.48(a)1
      9 (71.36 cM)5
    224371  NM_011724.31  NP_035854.31 
     1200137555 
    chicken
    (Gallus gallus)
    Aves XIRP16
    Gallus gallus xin actin-binding repeat containing ...
    25(a)
    1 ↔ 1
    2(4944068-4977259)
    lizard
    (Anolis carolinensis)
    Reptilia XIRP16
    xin actin-binding repeat containing 1
    28(a)
    1 ↔ 1
    6(716883-722630)
    zebrafish
    (Danio rerio)
    Actinopterygii xirp16
    xin actin-binding repeat containing 1
    23(a)
    1 ↔ 1
    2(24095328-24114532) ENSDARG00000030722


    ENSEMBL Gene Tree for XIRP1 (if available)
    TreeFam Gene Tree for XIRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for XIRP1 gene
    XIRP22  

    XIRP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for XIRP1 (see all 494)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0384474
    A breast cancer sample4--see VAR_0384472 R K mis40--------
    VAR_0384424
    A breast cancer sample4--see VAR_0384422 L H mis40--------
    rs1450946291,2
    C,Funtested139229856(+) CTCTTC/TGTCCC 4 K E mis11Minor allele frequency- T:0.00NA 4548
    rs1430077251,2
    C--39224456(+) AGCAC-/TGTG  
            
    TGTGT
    2 -- ds5001 int10--------
    rs680428941,2
    C--39224498(-) CCCAT-/CA    
       
    /CACA
    CACAC
    2 -- ds5001 int12NA 4
    rs1383552471,2
    C--39224510(+) GGGAT-/AGGGGC 2 -- ds5001 int10--------
    rs1844540111,2
    --39224592(+) AGCCTG/TCCCAC 2 -- ds5001 int10--------
    rs1893409081,2
    --39224637(+) TTGTGA/GCTGTT 2 -- ds5001 int10--------
    rs1448208731,2
    --39224640(+) GGCTG-/GGTTTTTC 2 -- cds10--------
    rs1812073291,2
    --39224649(+) TCTCCC/TCCTGC 2 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for XIRP1 (39224701 - 39234087 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for XIRP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XIRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for XIRP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609777    OMIM disorders: --

    5 diseases for XIRP1:    
    About MalaCards
    myofibrillar myopathy    myopathy    breast and colorectal cancer    squamous cell carcinoma
    colorectal cancer


    XIRP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): XIRP1

    Export disorders for XIRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for XIRP1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with XIRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Xin repeats define a novel actin-binding motif. (PubMed id 15454575)1, 2, 3, 9 Pacholsky D.... van der Ven P.F.M. (J. Cell Sci. 2004)
    2. Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP. (PubMed id 16631741)1, 2, 9 van der Ven P.F.M.... Fuerst D.O. (Exp. Cell Res. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. (PubMed id 12203715)1, 3 Sinn H.W....Lin J.J. (Dev. Dyn. 2002)
    5. Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis. (PubMed id 20657180)1 Lee D.J....Su G.H. (amp 2010)
    6. Differential involvement of sarcomeric proteins in myofibrillar myopathies: a morphological and immunohistochemical study. (PubMed id 19151983)1 Claeys K.G....FA1rst D.O. (Acta Neuropathol. 2009)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 165904 HGNC: 14301 AceView: CMYA1 Ensembl:ENSG00000168334 euGenes: HUgn165904
    ECgene: XIRP1 H-InvDB: XIRP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for XIRP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for XIRP1 gene:
    Search GeneIP for patents involving XIRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for XIRP1   OriGene RNAi products in human, mouse, rat for XIRP1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for XIRP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for XIRP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for XIRP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for XIRP1   OriGene Custom Protein Services for XIRP1  

     
     
     Block miRNA regulation of human, mouse, rat XIRP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing XIRP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XIRP1 Predesigned siRNA for gene silencing in human, mouse, rat XIRP1
     QuantiFast Probe-based Assays in human, mouse, rat XIRP1 QuantiTect SYBR Green Assays in human, mouse, rat XIRP1
     Custom PCR Arrays for XIRP1 Search Chromatin IP Primers for XIRP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XIRP1  Search GeneGlobe Interaction Network for XIRP1
     Regulatory tfbs in XIRP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for XIRP1 GenScript cDNA clones with any tag delivered in your preferred vector for XIRP1
     GenScript Custom Assay Services for XIRP1 GenScript Custom overexpressing Cell Line Services for XIRP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for XIRP1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     XIRP1 antibodies
     Antibodies for XIRP1
     See all of Abcam's Antibodies, Kits and Proteins for XIRP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for XIRP1
     Antibodies for XIRP1
     ELISAs for XIRP1
     CLIAs for XIRP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for XIRP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIRP1
     SwitchGear 3'UTR luciferase reporter plasmids for XIRP1
     SwitchGear Promoter luciferase reporter plasmids for XIRP1
     Search ThermoFisher Antibodies for XIRP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIRP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XIRP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for XIRP1
     LSBio Antibodies in human, mouse, rat for XIRP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      XIRP1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4