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XIAP Gene

protein-coding   GIFtS: 70
GCID: GC0XP122993

X-Linked Inhibitor Of Apoptosis

(Previous name: baculoviral IAP repeat-containing 4)
(Previous symbols: API3, BIRC4)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
X-Linked Inhibitor Of Apoptosis1 2     XLP22 5
API31 2 3 5     Baculoviral IAP Repeat-Containing 41
BIRC41 2 3 5     ILP12
Baculoviral IAP Repeat-Containing Protein 42 3     MIHA2
Inhibitor Of Apoptosis Protein 32 3     E3 Ubiquitin-Protein Ligase XIAP2
IAP-32 3     EC 6.3.2.-3
hIAP-32 3     IAP33
hIAP32 3     ILP3
IAP-Like Protein2 3     hILP3
X-Linked IAP2 3     X-Linked Inhibitor Of Apoptosis Protein3

External Ids:    HGNC: 5921   Entrez Gene: 3312   Ensembl: ENSG000001019667   OMIM: 3000795   UniProtKB: P981703   
ORGUL members:         

Export aliases for XIAP gene to outside databases

Previous GC identifers: GC0XP122823 GC0XP112378


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XIAP Gene:
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family
share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function.
This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and
inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting
enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3
and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing
results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.(provided by
RefSeq, Feb 2011)

GeneCards Summary for XIAP Gene:
XIAP (X-linked inhibitor of apoptosis) is a protein-coding gene. Diseases associated with XIAP include x-linked lymphoproliferative syndrome 2, and lymphoproliferative disease, x-linked. GO annotations related to this gene include ubiquitin-protein ligase activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is BIRC3.

UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170
Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates
inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well
as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of
CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.
Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3
ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1,
CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic
target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to
proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its
proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway,
targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD
and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of
innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of
the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a
caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and
CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES.
Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient
recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to
initiate a Wnt-specific transcriptional program

summary for XIAP Gene:
Inhibitor of apoptosis (IAPs) are a family of proteins that are the major regulators of apoptosis through
their interaction with the various components of the apoptotic signalling cascades. Originally discovered in
baculovirus, the human homologues are sometimes described as baculovirus IAP repeat containing (BIRC)
proteins. There are a number of different IAPs including neuronal apoptosis inhibitory protein (NAIP or
BIRC1), cellular IAPs (c-IAP-1 and c-IAP-2, or BIRC2 and BIRC3 respectively), X-chromosome linked IAP (XIAP
or BIRC4) and survivin (BIRC5). cIAP-1 and 2 function through interaction with TNF receptors and by binding
to the mitochondrial protein, SMAC, preventing it binding to XIAP. Thought to be the most potent apoptosis
suppressor, XIAP, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several
caspases, is up-regulated in a many tumour cell types.

Gene Wiki entry for XIAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the XIAP gene promoter:
         c-Fos   Sp1   AP-1   ATF-2   STAT5A   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXIAP promoter sequence
   Search Chromatin IP Primers for XIAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XIAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq25   HGNC cytogenetic band: Xq25

XIAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XIAP gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP122993:  view genomic region     (about GC identifiers)

Start:
122,993,574 bp from pter      End:
123,047,829 bp from pter
Size:
54,256 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase XIAP  
Size: 497 amino acids; 56685 Da
Subunit: Monomer, and homodimer. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic
suppressor activity. Interacts with TAB1/MAP3K7IP1 and AIFM1. Interaction with SMAC hinders binding of
TAB1/MAP3K7IP1 and AIFM1. Interacts with TCF25 and COMMD1. Interacts with SEPT4 isoform 6, but not with other
SEPT4 isoforms. Interacts with RIP1, RIP2, RIP3, RIP4, CCS and USP19. Interacts (via BIR 2 domain and BIR 3
domain) with HAX1 (via C-terminus) and this interaction blocks ubiquitination of XIAP/BIRC4. Interacts with the
monomeric form of BIRC5/survivin. Interacts with TLE3 and TCF7L2/TCF4
Selected PDB 3D structures from and Proteopedia for XIAP (see all 40):
1C9Q (3D)        1F9X (3D)        1G3F (3D)        1G73 (3D)        1I3O (3D)        1I4O (3D)    
Secondary accessions: D3DTF2 Q9NQ14

Explore the universe of human proteins at neXtProt for XIAP: NX_P98170

Explore proteomics data for XIAP at MOPED

Post-translational modifications: 

  • S-Nitrosylation down-regulates its E3 ubiquitin-protein ligase activity1
  • Autoubiquitinated and degraded by the proteasome in apoptotic cells1
  • Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal
    degradation1
  • Ubiquitination2 at Lys10, Lys31, Lys116, Lys168, Lys208, Lys322, Lys328, Lys358
  • Modification sites at PhosphoSitePlus

  • See XIAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158.2  NP_001191330.1  

    ENSEMBL proteins: 
     ENSP00000405529   ENSP00000400637   ENSP00000360242   ENSP00000347858   ENSP00000395230  
    Reactome Protein details: P98170

    XIAP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for XIAP
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for XIAP
    OriGene Protein Over-expression Lysate for XIAP
    OriGene MassSpec for XIAP
    OriGene Custom Protein Services for XIAP
    GenScript Custom Purified and Recombinant Proteins Services for XIAP
    Novus Biologicals XIAP Proteins
    Novus Biologicals XIAP Lysates
    Sino Biological Recombinant Protein for XIAP
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for XIAP

    XIAP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of XIAP
    R&D Systems Antibodies for XIAP
    Cell Signaling Technology (CST) Antibodies for XIAP 
    OriGene Antibodies for XIAP
    OriGene Custom Antibody Services for XIAP
    Novus Biologicals XIAP Antibodies
    Search for Antibodies for XIAP at Abcam
    Cloud-Clone Corp. Antibodies for XIAP
    ThermoFisher Antibody for XIAP
    LSBio Antibodies in human, mouse, rat for XIAP

    XIAP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for XIAP
    R&D Systems ELISAs for XIAP         (see all)
    GenScript Custom Assay Services for XIAP
    Enzo Life Sciences assays for XIAP
    Cloud-Clone Corp. ELISAs for XIAP
    Cloud-Clone Corp. CLIAs for XIAP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BIRC: Baculoviral IAP repeat containing

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR001370 BIR

    Graphical View of Domain Structure for InterPro Entry P98170

    ProtoNet protein and cluster: P98170

    2 Blocks protein domains:
    IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170
    Domain: The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The
    second BIR domain is sufficient to inhibit CASP3 and CASP7, while the third BIR is involved in CASP9 inhibition.
    The interactions with DIABLO/SMAC and PRSS25 are mediated by the second and third BIR domains
    Similarity: Belongs to the IAP family
    Similarity: Contains 3 BIR repeats
    Similarity: Contains 1 RING-type zinc finger


    XIAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XIAP_HUMAN, P98170
    Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates
    inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well
    as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of
    CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.
    Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3
    ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1,
    CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic
    target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to
    proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its
    proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway,
    targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD
    and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of
    innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of
    the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a
    caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and
    CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES.
    Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient
    recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to
    initiate a Wnt-specific transcriptional program

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA19473982
    GO:0005515protein binding IPI11257230
    GO:0008270zinc ion binding IEA--
    GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA9230442
         
    XIAP for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for XIAP:
     Decreased influenza A virus in  Decreased viability after Chla  Increased cell death HMECs cel  Increased cilium length 
     Increased cilium length after  

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Xiap) (see all 16):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  muscle  normal  other  reproductive system 

    XIAP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for XIAP: Xiaptm1Thsn Xiaptm1Vdr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XIAP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for XIAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XIAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XIAP

    miRNA
    Products:
        
    miRTarBase miRNAs that target XIAP:
    hsa-mir-192-5p (MIRT026131), hsa-mir-106a-5p (MIRT048312), hsa-mir-125b-5p (MIRT045901), hsa-mir-101-3p (MIRT027269), hsa-mir-181b-5p (MIRT006951), hsa-mir-429 (MIRT006675), hsa-mir-200b-3p (MIRT006671), hsa-mir-96-5p (MIRT027901), hsa-mir-34a-3p (MIRT006260), hsa-mir-215-5p (MIRT024546), hsa-mir-181a-5p (MIRT006950), hsa-mir-17-5p (MIRT050938), hsa-let-7e-5p (MIRT051500), hsa-mir-200c-3p (MIRT006672)

    Block miRNA regulation of human, mouse, rat XIAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate XIAP (see all 166):
    hsa-miR-579 hsa-miR-100* hsa-miR-146a hsa-miR-106a hsa-miR-3653 hsa-miR-200b hsa-miR-130b hsa-miR-130a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for XIAP
    Predesigned siRNA for gene silencing in human, mouse, rat XIAP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for XIAP

    Clone
    Products:
         
    OriGene clones in human, mouse for XIAP (see all 6)
    OriGene ORF clones in mouse, rat for XIAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): XIAP (NM_001167)
    Sino Biological Human cDNA Clone for XIAP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XIAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XIAP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for XIAP
    Browse ESI BIO Cell Lines and PureStem Progenitors for XIAP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XIAP_HUMAN, P98170: Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion3
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA15665297
    GO:0005829cytosol TAS--

    XIAP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XIAP About   (see all 28)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44
    2Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35
    Apoptosis Signaling Pathways0.35
    3Activation of caspases through apoptosome-mediated cleavage
    SMAC-mediated apoptotic response0.43
    SMAC binds to IAPs0.00
    SMAC-mediated dissociation of IAP-caspase complexes0.00
    4Activation of BH3-only proteins
    Intrinsic Pathway for Apoptosis0.68
    Apoptotic factor-mediated response0.00
    5Focal adhesion
    Focal adhesion0.65

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for XIAP
        Apoptosis Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for XIAP
        TGF-Beta Pathway
    TRAIL Pathway
    Akt Signaling
    Apoptotic Pathways in Synovial Fibroblasts
    RANK Signaling in Osteoclasts

    1 Cell Signaling Technology (CST) Pathway for XIAP
        Apoptosis and Autophagy

    Selected GeneGo (Thomson Reuters) Pathways for XIAP (see all 10)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Caspase cascade
    Development Neurotrophin family signaling
    Apoptosis and survival FAS signaling cascades
    Transcription PPAR Pathway

    5 BioSystems Pathways for XIAP
        Apoptosis
    NOD pathway
    BMP receptor signaling
    Caspase cascade in apoptosis
    TGF-beta receptor signaling

    2 Sino Biological Pathways for XIAP
        EGFR Signaling Pathway
    Death Receptor Signaling

    3 Reactome Pathways for XIAP
        deactivation of the beta-catenin transactivating complex
    SMAC-mediated dissociation of IAP:caspase complexes
    SMAC binds to IAPs

    1 PharmGKB Pathway for XIAP
        Busulfan Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for XIAP) (see all 8):
        NF-kappa B signaling pathway
    Ubiquitin mediated proteolysis
    Apoptosis
    Focal adhesion
    Toxoplasmosis


    XIAP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including XIAP (see all 11): 
              NFKB Signaling Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for XIAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for XIAP (P981701, 2, 3 ENSP000003478584) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP7P552101, 2, 3EBI-517127,EBI-523958 MINT-15054 MINT-15053 I2D: score=7 
    UBE2D1P516681, 2, 3, ENSP000003630194EBI-517127,EBI-743540 MINT-4543556 I2D: score=4 STRING: ENSP00000363019
    CASP3P425742, 3, ENSP000003110324MINT-13839 MINT-13838 I2D: score=7 STRING: ENSP00000311032
    MAGED1Q9Y5V32, 3, ENSP000003648474MINT-14016 MINT-14015 I2D: score=3 STRING: ENSP00000364847
    RAC1P630001, 2EBI-517127,EBI-413628 MINT-8313553 MINT-8319042 MINT-8319067
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006974cellular response to DNA damage stimulus IEP18049476
    GO:0016055Wnt signaling pathway IEA--
    GO:0016567protein ubiquitination IDA19473982
    GO:0030510regulation of BMP signaling pathway TAS18414036

    XIAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for XIAP
    6 ApexBio Compounds for XIAP     About this table
    CompoundAction CAS #
    AT-406 (SM-406)antagonist of the IAPs[1071992-99-8]
    Birinapant (TL32711)inhibitor of IAP family proteins[1260251-31-7]
    EmbelinCell-permeable, non-peptide inhibitor of XIAP[550-24-3]
    GDC-0152potent small-molecule antagonist of IAP proteins[873652-48-3]
    LCL161oral small molecule antagonist of IAPs[1005342-46-0]
    YM155smallest member of IAP gene family. [781661-94-7]

    Compounds for XIAP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    EmbelinInhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor[550-24-3]

    2 DrugBank Compounds for XIAP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide-- --target--17139284 17016423 10592235
    N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE-- --target----

    Selected Novoseek inferred chemical compound relationships for XIAP gene (see all 80)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ciap2 86.5 17 16115895 (5), 17255535 (3), 17208224 (2), 16892011 (1) (see all 9)
    miha 85.4 24 8036709 (4), 14555970 (4), 19483655 (3), 18410452 (2) (see all 10)
    ciap1 77.1 5 16489035 (1), 16892011 (1), 15665297 (1), 16957584 (1) (see all 5)
    phenoxodiol 64.4 17 17257402 (4), 15666998 (3)
    tab-1 61.5 7 9878061 (4), 19531477 (2), 19966933 (1)
    roscovitine 58.9 6 14724573 (4), 16230394 (1), 14679020 (1)
    cisplatin 58.5 109 15610860 (7), 11145600 (5), 14612499 (5), 15863139 (5) (see all 32)
    tetrapeptide 57.7 3 19819692 (1), 11511363 (1), 11257230 (1)
    flavopiridol 56.1 23 17308065 (7), 15385934 (4), 12517783 (2), 18065490 (2) (see all 6)
    indole-3-carbinol 52.6 2 16082211 (1), 15811958 (1)



    XIAP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for XIAP gene (2 alternative transcripts): 
    NM_001167.3  NM_001204401.1  

    Unigene Cluster for XIAP:

    X-linked inhibitor of apoptosis
    Hs.356076  [show with all ESTs]
    Unigene Representative Sequence: NM_001167
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422098 ENST00000481776 ENST00000497906 ENST00000468691 ENST00000430625
    ENST00000371199(uc010nqu.3 uc004etx.3 uc010nqv.3) ENST00000497640
    ENST00000355640 ENST00000468503 ENST00000496602 ENST00000434753
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-579 hsa-miR-100* hsa-miR-146a hsa-miR-106a hsa-miR-3653 hsa-miR-200b hsa-miR-130b hsa-miR-130a*
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    Additional mRNA sequence: 

    AK130423.1 AK309704.1 AK313883.1 BC030771.1 BC032729.1 NR_037916.1 U32974.1 

    7 DOTS entries:

    DT.410012  DT.305509  DT.426377  DT.445803  DT.121299809  DT.91798400  DT.95262880 

    Selected AceView cDNA sequences (see all 204):

    AW117433 AW665401 BM459898 AI675716 BQ777093 AI475097 AA902901 AI332508 
    BM313390 AA075090 BM983359 AW089540 BG616695 BM665536 AI252632 AI216770 
    AA824488 BU622707 BM711709 AI299965 AA748773 AI718169 NM_001167 AA878394 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XIAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    XIAP Expression
    About this image


    XIAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    XIAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XIAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356076

    UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170
    Tissue specificity: Ubiquitous, except peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including XIAP (see all 11): 
              NFKB Signaling Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XIAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for XIAP gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xiap1 , 5 X-linked inhibitor of apoptosis1, 5 90.05(n)1
    89.52(a)1
      X (23.19 cM)5
    117981  NM_009688.21  NP_033818.21 
     420596795 
    chicken
    (Gallus gallus)
    Aves XIAP1 X-linked inhibitor of apoptosis 66.67(n)
    59.18(a)
      395280  NM_204588.1  NP_989919.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    1 → many
    GL343409.1(44539-55087)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX846906.12   -- 73.89(n)    BX846906.1 
    zebrafish
    (Danio rerio)
    Actinopterygii xiap1 X-linked inhibitor of apoptosis 55.56(n)
    51.06(a)
      373108  NM_194396.2  NP_919377.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Iap26
    th6
    thread
    30(a)
    25(a)
    many ↔ many
    many ↔ many
    2R(11819675-11822330)
    3L(16031510-16044134)


    ENSEMBL Gene Tree for XIAP (if available)
    TreeFam Gene Tree for XIAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for XIAP gene
    BIRC32  BIRC72  NLRC42  NAIP2  BIRC22  BIRC82  
    4 SIMAP similar genes for XIAP using alignment to 3 protein entries:     XIAP_HUMAN (see all proteins):
    ILP3    BIRC8    NAIP    BIRC2

    XIAP for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for XIAP
    PGOHUM00000238917 PGOHUM00000242397 PGOHUM00000240868


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for XIAP (see all 1009)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048947641,2
    Cpathogenic1122974250(+) AAGTTG/TAAAAC 5 E * stg1 int10--------
    rs2005107711,2
    C--122945894(+) ACTTA-/TTTTTATT 1 -- us2k10--------
    rs1814507221,2
    --122945920(+) TAAATA/TTTAAT 1 -- us2k10--------
    rs351471431,2
    F--122945961(+) TTTATG/TTTTAT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs120147401,2
    C,F,A,H--122945997(+) tcaccG/Caggct 1 -- us2k14Minor allele frequency- C:0.00NA CSA 7
    rs1900325601,2
    C--122946255(+) CGGCCC/TATTTA 3 -- us2k10--------
    rs70642241,2
    C,A--122946415(+) actcaG/Ccacca 3 -- us2k15Minor allele frequency- C:0.11WA NA CSA 9
    rs59565781,2
    C,F,A,H--122946759(+) TCGCTC/GCCTTC 3 -- us2k110Minor allele frequency- G:0.55NS WA NA CSA 197
    rs283826991,2
    C,F--122946829(+) GAAAAC/TTGAGG 3 -- us2k15Minor allele frequency- T:0.07NS 188
    rs59583181,2
    C,F,A,H--122946885(+) TAGGGT/CACCCA 3 -- us2k123Minor allele frequency- C:0.40NS EA WA NA CSA 2146

    HapMap Linkage Disequilibrium report for XIAP (122993574 - 123047829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for XIAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507991CNV Insertion20534489
    dgv2471e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): XIAP
    Locus Specific Mutation Databases (LSDB): XIAP

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XIAP
    DNA2.0 Custom Variant and Variant Library Synthesis for XIAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 300079   
    OMIM disorders: 300635  
    UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170
  • Lymphoproliferative syndrome, X-linked, 2 (XLP2) [MIM:300635]: A rare immunodeficiency characterized by
    extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal
    mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for XIAP (see all 102):    
    About MalaCards
    x-linked lymphoproliferative syndrome 2    lymphoproliferative disease, x-linked    chronic neutrophilic leukemia    thymic hyperplasia
    pleomorphic adenoma    pleomorphic adenoma carcinoma    cowpox    glucocorticoid resistance
    ovarian epithelial cancer    carotid stenosis    wilson disease    transient cerebral ischemia
    dyskeratosis congenita    pancytopenia    malignant pleural mesothelioma    hemophagocytic lymphohistiocytosis
    malignant mesothelioma    inverted papilloma    leukemia/lymphoma, t-cell    malignant glioma

    2 diseases from the University of Copenhagen DISEASES database for XIAP:
    Leukemia     Lymphoma

    XIAP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for XIAP gene (see all 64)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia b-cell 66.6 1 14996703 (1)
    cancer 62.4 99 15126334 (3), 17342344 (3), 10815900 (3), 17121920 (3) (see all 61)
    tumors 60.2 153 17947468 (4), 18309651 (4), 18259199 (3), 16983704 (3) (see all 78)
    leukemia 57.7 20 17308065 (2), 15756021 (1), 18250043 (1), 12642862 (1) (see all 17)
    necrosis 57.1 18 16291753 (1), 17332931 (1), 9418907 (1), 15604280 (1) (see all 13)
    leukemia lymphocytic chronic 55.1 4 16983704 (1), 20354122 (1), 15703780 (1), 15914559 (1)
    lymphocytic leukemia chronic b-cell 53.7 1 17463171 (1)
    leukemia t-cell 47.5 1 15756021 (1)
    colon cancer 45.6 13 18351648 (4), 19737940 (4), 15604280 (1), 18388920 (1)
    ovarian cancer 43.5 30 15863139 (6), 11280739 (4), 14612499 (3), 12237081 (2) (see all 13)

    GeneTests: XIAP
    GeneReviews: XIAP
    Genetic Association Database (GAD): XIAP
    Human Genome Epidemiology (HuGE) Navigator: XIAP (12 documents)

    Export disorders for XIAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XIAP gene, integrated from 10 sources (see all 971):
    (articles sorted by number of sources associating them with XIAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. (PubMed id 8654366)1, 2, 3 Duckett C.S.... Thompson C.B. (EMBO J. 1996)
    2. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)1, 2, 3 Liston P.... Korneluk R.G. (Nature 1996)
    3. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). (PubMed id 14645242)1, 2, 9 Dan H.C.... Cheng J.Q. (J. Biol. Chem. 2004)
    4. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. (PubMed id 11447297)1, 2, 9 Suzuki Y.... Takahashi R. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    5. Molecular interaction between HAX-1 and XIAP inhibits apoptosis. (PubMed id 20171186)1, 2, 9 Kang Y.J.... Park S.G. (Biochem. Biophys. Res. Commun. 2010)
    6. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. (PubMed id 12121969)1, 2, 9 MacFarlane M.... Cohen G.M. (J. Biol. Chem. 2002)
    7. XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome. (PubMed id 17080092)1, 2, 9 Rigaud S.... Latour S. (Nature 2006)
    8. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PubMed id 15665297)1, 2, 9 Samuel T.... Reed J.C. (Cancer Res. 2005)
    9. Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. (PubMed id 11257231)1, 2, 9 Huang Y.... Wu H. (Cell 2001)
    10. Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation. (PubMed id 22103349)1, 2 Lewis E.M.... Wilkinson J.C. (Biochemistry 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 331 HGNC: 592 AceView: BIRC4 Ensembl:ENSG00000101966 euGenes: HUgn331
    ECgene: XIAP Kegg: 331 H-InvDB: XIAP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for XIAP Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=XIAP[genesymbol]
    BIRC4basehttp://bioinf.uta.fi/BIRC4base/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/birc4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for XIAP gene:
    Search GeneIP for patents involving XIAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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