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XIAP Gene

protein-coding GIFtS: 63

GC0XP122823

X-linked inhibitor of apoptosis
(Previous name: baculoviral IAP repeat-containing 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: API3, BIRC4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
API3 ^², ³, ⁵
BIRC4 ^², ³, ⁵
EC 6.3.2.- ^³
HILP ^³
IAP3 ^³
ILP1 ^²
MIHA ^²
OTTHUMP00000023975 ^²
OTTHUMP00000196392 ^²
XLP2 ^², ⁵
hILP ^¹

Descriptions
E3 ubiquitin-protein ligase XIAP ^³
IAP-like protein ^³
Inhibitor of apoptosis protein 3 ^³
X-linked IAP ^³
X-linked inhibitor of apoptosis ^²
X-linked inhibitor of apoptosis protein ^³
apoptosis inhibitor 3 ^²
baculoviral IAP repeat-containing 4 ^¹, ²
baculoviral IAP repeat-containing protein 4 ^²

External Ids
HGNC: 592¹
Entrez Gene: 331²
UniProtKB: P98170³
Ensembl: ENSG00000101966⁷

Search outside databases for aliases for XIAP gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for XIAP:

The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis

through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. This protein

inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. It also

inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and

caspase-7. [provided by RefSeq]

UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170

Function: Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal

degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and

-9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B

Gene Wiki entry for XIAP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25 Ensembl cytogenetic band: Xq25 HGNC cytogenetic band: Xq25

XIAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP122823: (about GC identifiers)

Start:	122,821,729 bp from pter
End:	122,875,503 bp from pter
Size:	53,775 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170 (See protein sequence)

Recommended Name: Baculoviral IAP repeat-containing protein 4

Size: 497 amino acids; 56685 Da

Subunit: Monomer, and homodimer. Interacts with SMAC and with PRSS25; these interactions inhibit

apoptotic suppressor activity. Interacts with MAP3K7IP1 and AIFM1. Interaction with SMAC hinders

binding of MAP3K7IP1 and AIFM1. Interacts with TCF25

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

1C9Q (3D)

1F9X (3D)

1G3F (3D)

1G73 (3D)

1I3O (3D)

1I4O (3D)

1I51 (3D)

1KMC (3D)

1NW9 (3D)

1TFQ (3D)

1TFT (3D)

2ECG (3D)

2JK7 (3D)

2OPY (3D)

2OPZ (3D)

2POI (3D)

2POP (3D)

2QRA (3D)

2VSL (3D)

3CLX (3D)

3CM2 (3D)

3CM7 (3D)

3EYL (3D)

Secondary accessions: Q9NQ14

Post-translational modifications:

Ubiquitinated and degraded by the proteasome in apoptotic cells¹

Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against

proteasomal degradation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001158.2

ENSEMBL proteins:

ENSP00000347858 ENSP00000360242

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for XIAP
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XIAP)
	Human Recombinant Proteins from Abnova (XIAP)

OriGene Purified Recombinant Human Protein: XIAP

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	TAS	8654366
GO:0005829	cytosol	TAS	8654366

About this table

Antibodies for XIAP:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of XIAP
	Sigma-Aldrich Antibodies for XIAP
	R&D Systems Antibodies for XIAP
	Cell Signaling Technology (CST) Antibodies for XIAP
	Antibodies from Abcam (XIAP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XIAP)
	Novus Biologicals Antibodies for XIAP

Assays for XIAP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for XIAP (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P98170

ProtoNet protein and cluster: P98170

2 Blocks protein families:

IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)

IPB001841 Zn-finger

UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170

Domain: The first BIR domain is involved in interaction with MAP3K7IP1 and is important for

dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the

third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated

by the second and third BIR domains

Similarity: Belongs to the IAP family

Similarity: Contains 3 BIR repeats

Similarity: Contains 1 RING-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XIAP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XIAP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001167

Applied Biosystems Silencer® siRNAs for XIAP

Sigma-Aldrich siRNA and siRNA Panels for XIAP

Sigma-Aldrich shRNA Panels and shRNA for XIAP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XIAP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001167
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001167
untagged cDNA clones in CMV expression vector (see all 4): AK055352

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001167

UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170

Function: Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal

degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and

-9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B

Enzyme Number (IUBMB): EC 6.3.2.-

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Xiap):

cellular	endocrine/exocrine gland	hematopoietic system	immune system	life span-post-weaning/aging
normal	reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11801603 16282325 16887178
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	IEA	--
GO:0043027	caspase inhibitor activity	IDA	9230442
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for XIAP (Your Favorite Gene powered by Ingenuity) (see all 7 )

Induction of Apoptosis by HIV1
BMP signaling pathway
Apoptosis Signaling
Protein Ubiquitination Pathway
Molecular Mechanisms of Cancer

GeneDecks XIAP for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for XIAP

5/110 Interacting proteins for XIAP (ENSP00000360242³ P98170^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 110 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HTRA2	O43464¹	STRING (score=.997) EBI-517127, EBI-517086
UBC	P62988²	STRING (score=.879) MINT-4543408 MINT-4543573 MINT-4543421
CASP3	P42574²	STRING (score=.999) MINT-13839 MINT-13838
CASP7	P55210²	STRING (score=.999) MINT-15054 MINT-15053
MAGED1	Q9Y5V3²	STRING (score=.95) MINT-14016 MINT-14015

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006916	anti-apoptosis	TAS	8654366
GO:0019941	modification-dependent protein catabolic process	IEA	--
GO:0043154	negative regulation of caspase activity	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for XIAP:

Antagonist

Compounds for XIAP available from Tocris Bioscience

Compound	Action	CAS number
Embelin	Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor	[550-24-3]

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10/27 Novoseek chemical compound relationships for XIAP gene (see all 27 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ciap2	86.99	16	16115895 (5), 17255535 (3), 17208224 (2), 16892011 (1) (see all 8)
miha	85.28	21	8036709 (4), 14555970 (4), 18410452 (2), 18719914 (2) (see all 9)
ciap1	76.40	4	16489035 (1), 16892011 (1), 15665297 (1), 16957584 (1)
phenoxodiol	66.27	17	17257402 (4), 15666998 (3)
tetrapeptide	58.02	2	11511363 (1), 11257230 (1)
apicidin	50.41	3	14687026 (2)
noxa	48.09	2	17881028 (1), 17718901 (1)
tab-1	46.64	4	9878061 (4)
phosphatidylinositol	44.71	7	14612499 (1), 17308080 (1), 17049600 (1), 18991571 (1) (see all 7)
bryostatin 1	33.62	5	11777344 (4), 11770703 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XIAP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XIAP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001167

Sigma-Aldrich siRNA and siRNA Panels for XIAP

Sigma-Aldrich shRNA Panels and shRNA for XIAP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001167

REFSEQ mRNAs for XIAP gene:

NM_001167.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001167

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001167
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001167
                                 untagged cDNA clones in CMV expression vector (see all 4): AK055352

Additional cDNA sequence:

AK130423.1 AK309704.1 AK313883.1 BC030771.1 BC032729.1 U32974.1

8 DOTS entries:

DT.410012 DT.305509 DT.426377 DT.445803 DT.99970493 DT.121299809 DT.91798400 DT.95262880

24/204 AceView cDNA sequences (see all 204 ):

R63205 BG616695 BU622716 AI299965 AW665401 AI216770 BM459898 AA075090

AI659113 BM711709 AA977511 AA824488 BE858847 AI670756 AA987840 AI302822

AI675716 AW117433 AI003143 AA902901 BE502846 AA878394 AW089540 AA459245

Unigene Cluster for XIAP:

X-linked inhibitor of apoptosis

Hs.356076 [show with all ESTs]

Unigene Representative Sequence: NM_001167

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000355640 ENST00000371199

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XIAP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XIAP

¹ / ²

19 probe-sets matching XIAP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
51813_at²	U95-B	1	1.00	1.00	0.24	1.85	--	--	--	--	--
78549_at²	U95-E	1	1.00	1.00	0.86	0.74	--	--	--	--	--
92143_r_at²	U95-D	1	1.00	1.00	0.62	0.64	--	--	--	--	--
69767_at²	U95-E	1	0.88	1.00	0.46	0.83	--	--	--	--	--
1646_at²	U95-A	2	0.44	0.54	0.04	0.36	--	--	--	--	--
225858_s_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
235222_x_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
225859_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
243026_x_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
228363_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
206536_s_at²	U133-A	2	1.00	0.95	--	--	--	--	--	--	--
206537_at²	U133-A	2	0.46	0.71	--	--	--	--	--	--	--
225858_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235222_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225859_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
243026_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228363_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206536_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
206537_at²	U133Plus2	2	0.46	0.71	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.356076
UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170
Tissue specificity: Ubiquitous, except peripheral blood leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XIAP gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	XIAP¹	--	X-linked inhibitor of apoptosis	90.74(n) 86.92(a)	442989 XM_538165.2 XP_538165.2
chimpanzee (Pan troglodytes)	XIAP¹	--	X-linked inhibitor of apoptosis	98.93(n) 98.39(a)	473765 XM_529138.2 XP_529138.2
cow (Bos taurus)	XIAP¹	--	X-linked inhibitor of apoptosis	91.75(n) 87.73(a)	281647 XM_583068.2 XP_583068.2
rat (Rattus norvegicus)	Xiap¹	--	X-linked inhibitor of apoptosis	89.78(n) 89.92(a)	63879 NM_022231.2 NP_071567.1
mouse (Mus musculus)	Xiap^{1, 5}	X⁵	X-linked inhibitor of apoptosis^{1, 5}	89.38(n)¹ 87.7(a)¹	11798¹ NM_009688.1¹ NP_033818.1¹ AF311606⁵ AK003723⁵ (see all 20)

About this table Species with no ortholog for XIAP

ENSEMBL Gene Tree for XIAP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for XIAP gene

BIRC3² BIRC7² ENSG00000163098² BIRC2² BIRC8²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/408 NCBI SNPs in XIAP are shown (see all 408 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9856^1,2	A,C,F,H,O	122873322(+)	`CACTTC/TAATAA`	1	--	ut3¹ ese³		18	MN EU EA WA NA NS	1255
	rs5958318^1,2	A,C,F,H	122820503(+)	`TAGGGT/CACCCA`	1	--	ng5¹		9	EU EA WA NS	567
--	rs5958343^1,2	A,C,F,H	122873953(+)	`catgaT/Attaaa`	1	--	ut3¹		12	EU EA WA NA NS	675
	rs10521711^1,2	C,F,H	122875607(-)	`GCCTAC/AGTACA`	1	--	ng3¹		17	NS NA EU EA WA	805
	rs8371^1,2	C,F,H	122873596(+)	`AACTAC/TTCTTT`	1	--	ut3¹ ese³		22	MN NA EU EA WA NS	1576
	rs17330637^1,2	C,F,H	122871386(+)	`ACTTAA/CCAGCA`	1	--	ut3¹ ese³		9	NA NS WA	380
--	rs28382744^1,2	C,F,H	122870105(+)	`TTACCA/GTTAGG`	1	--	ut3¹		9	NS EU EA WA	608
--	rs5956578^1,2	A,C,F	122820377(+)	`tcgctG/CCCTTC`	1	--	ng5¹		5	NS	150
--	rs17334746^1,2	C,F,H	122870388(+)	`AAACCT/CATTGT`	1	--	ut3¹		12	NA NS EU EA WA	703
	rs5956583^1,2	C,F,H	122862192(+)	`TATGCA/CAGATG`	1	Q/P	mis¹		17	EU EA WA NA NS	963

About this table

HapMap Linkage Disequilibrium images for XIAP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300079 disorders: 300635

UniProtKB/Swiss-Prot: XIAP_HUMAN, P98170

Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2)

[MIM:300635]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection

with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired

hypogammaglobulinemia, pancytopenia and malignant lymphoma

10/63 Novoseek disease relationships for XIAP gene (see all 63 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia b-cell	66.79	1	14996703 (1)
cancer	60.13	88	15126334 (3), 17342344 (3), 10815900 (3), 17121920 (3) (see all 52)
tumors	58.19	132	17947468 (4), 18309651 (4), 18259199 (3), 16983704 (3) (see all 64)
necrosis	57.28	18	16291753 (1), 17332931 (1), 9418907 (1), 15604280 (1) (see all 13)
leukemia lymphocytic chronic	55.57	3	16983704 (1), 15703780 (1), 15914559 (1)
leukemia	55.05	18	17308065 (2), 15756021 (1), 18250043 (1), 12642862 (1) (see all 16)
lymphocytic leukemia chronic b-cell	53.81	1	17463171 (1)
leukemia t-cell	49.74	1	15756021 (1)
colon cancer	42.67	7	18351648 (4), 15604280 (1), 18388920 (1)
ovarian cancer	42.41	28	15863139 (6), 11280739 (4), 14612499 (3), 12237081 (2) (see all 11)

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GeneTests: XIAP

Lymphoproliferative Disease

Human Genome Epidemiology Navigator: XIAP (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Yale Researchers Find Phenoxodiol Restores Sensitivity to Chemotherapy in Some Women With Ovarian, Fallopian Tube or Primary Peritoneal Cancer

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/689 PubMed articles for XIAP gene (see all 689 ):

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. (PubMed id 8654366)^{2, 3, 4} Duckett C.S....Thompson C.B. (1996)
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)^{2, 3, 4} Liston P.... Korneluk R.G. (1996)
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). (PubMed id 14645242)^{1, 3, 4} Dan H.C....Cheng J.Q. (2004)
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. (PubMed id 11447297)^{1, 3, 4} Suzuki Y.... Takahashi R. (2001)
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. (PubMed id 12121969)^{1, 3, 4} MacFarlane M....Cohen G.M. (2002)
XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome. (PubMed id 17080092)^{1, 3, 4} Rigaud S.... Latour S. (2006)
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. (PubMed id 11257231)^{1, 3, 4} Huang Y....Wu H. (2001)
Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein. (PubMed id 18068114)^{3, 4} Steen H. and Lindholm D. (2008)
Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP. (PubMed id 17967870)^{3, 4} Wilkinson J.C.... Duckett C.S. (2008)
Crystal structure of the BIR1 domain of XIAP in two crystal forms. (PubMed id 17698078)^{3, 4} Lin S.C....Wu H. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 331	HGNC: 592	AceView: BIRC4	Ensembl:ENSG00000101966	euGenes: HUgn331
ECgene: XIAP	H-InvDB: XIAP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=XIAP
BIRC4base	http://bioinf.uta.fi/BIRC4base/
NIEHS-SNPs	http://egp.gs.washington.edu/data/birc4/

Licensable Technologies for XIAP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for XIAP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XIAP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XIAP		Antibodies for XIAP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XIAP		Small molecules for XIAP
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (XIAP)
	Antibodies (XIAP)
	Chimera RNAi (XIAP)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for XIAP

	Recombinant Proteins (XIAP)
	Antibodies (XIAP)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for XIAP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for XIAP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
XIAP Gene at Home site.
Version 2.41.1
server5.xennexinc.com

XIAP Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for XIAP

Summaries
for XIAP

Genomic Location
for XIAP

Proteins
for XIAP

Protein Domains/
Families
for XIAP

Gene Function
for XIAP

Pathways & Interactions
for XIAP

Drugs & Compounds
for XIAP

Transcripts
for XIAP

Expression
for XIAP

Orthologs
for XIAP

Paralogs
for XIAP

SNPs/Variants
for XIAP

Disorders & Mutations
for XIAP

Medical News
for XIAP

Publications
for XIAP

Search for XIAP

Genome Databases showing XIAP

Other Databases showing XIAP

Specialized Databases showing XIAP

Licensable Technologies
for XIAP

Services
for XIAP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XIAP (Gene Symbol)
API3
BIRC4
EC 6.3.2.-
HILP
IAP3
ILP1
MIHA
OTTHUMP00000023975
OTTHUMP00000196392
XLP2
hILP
E3 ubiquitin-protein ligase XIAP
IAP-like protein
Inhibitor of apoptosis protein 3
X-linked IAP
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis protein
apoptosis inhibitor 3
baculoviral IAP repeat-containing 4
baculoviral IAP repeat-containing protein 4

XIAP Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor XIAP

Summariesfor XIAP

Genomic Locationfor XIAP

Proteinsfor XIAP

Protein Domains/Familiesfor XIAP

Gene Functionfor XIAP

Pathways & Interactionsfor XIAP

Drugs & Compoundsfor XIAP

Transcriptsfor XIAP

Expression for XIAP

Orthologsfor XIAP

Paralogsfor XIAP

SNPs/Variantsfor XIAP

Disorders & Mutationsfor XIAP

Medical Newsfor XIAP

Publicationsfor XIAP

Search for XIAP

Genome Databases showing XIAP

Other Databases showing XIAP

Specialized Databases showing XIAP

Licensable Technologiesfor XIAP

Servicesfor XIAP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XIAP

Summaries
for XIAP

Genomic Location
for XIAP

Proteins
for XIAP

Protein Domains/
Families
for XIAP

Gene Function
for XIAP

Pathways & Interactions
for XIAP

Drugs & Compounds
for XIAP

Transcripts
for XIAP

Expression
for XIAP

Orthologs
for XIAP

Paralogs
for XIAP

SNPs/Variants
for XIAP

Disorders & Mutations
for XIAP

Medical News
for XIAP

Publications
for XIAP

Licensable Technologies
for XIAP

Services
for XIAP