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Aliases for XIAP Gene

Aliases for XIAP Gene

  • X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase 2 3
  • Baculoviral IAP Repeat-Containing Protein 4 3 4
  • Inhibitor Of Apoptosis Protein 3 3 4
  • IAP-Like Protein 3 4
  • X-Linked IAP 3 4
  • HIAP-3 3 4
  • BIRC4 3 4
  • IAP-3 3 4
  • HIAP3 3 4
  • API3 3 4
  • X-Linked Inhibitor Of Apoptosis Protein 4
  • Baculoviral IAP Repeat-Containing 4 2
  • X-Linked Inhibitor Of Apoptosis 2
  • EC 6.3.2.- 4
  • ILP1 3
  • MIHA 3
  • XLP2 3
  • IAP3 4
  • HILP 4
  • ILP 4

External Ids for XIAP Gene

Previous HGNC Symbols for XIAP Gene

  • API3
  • BIRC4

Previous GeneCards Identifiers for XIAP Gene

  • GC0XP122823
  • GC0XP122993
  • GC0XP112378

Summaries for XIAP Gene

Entrez Gene Summary for XIAP Gene

  • This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

GeneCards Summary for XIAP Gene

XIAP (X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with XIAP include lymphoproliferative syndrome, x-linked, 2 and lymphoproliferative syndrome, x-linked, 1. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is NAIP.

UniProtKB/Swiss-Prot for XIAP Gene

  • Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

Tocris Summary for XIAP Gene

  • The inhibitor of apoptosis (IAP) family of proteins are major regulators of apoptosis through interaction with components of the apoptotic signaling cascades. Discovered in baculovirus, human homologs can be described as baculovirus IAP repeat containing (BIRC) proteins.

Gene Wiki entry for XIAP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XIAP Gene

Genomics for XIAP Gene

Regulatory Elements for XIAP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for XIAP Gene

Chromosome:
X
Start:
123,859,724 bp from pter
End:
123,913,979 bp from pter
Size:
54,256 bases
Orientation:
Plus strand

Genomic View for XIAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XIAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XIAP Gene

Proteins for XIAP Gene

  • Protein details for XIAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98170-XIAP_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase XIAP
    Protein Accession:
    P98170
    Secondary Accessions:
    • D3DTF2
    • Q9NQ14

    Protein attributes for XIAP Gene

    Size:
    497 amino acids
    Molecular mass:
    56685 Da
    Quaternary structure:
    • Monomer, and homodimer. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with TAB1/MAP3K7IP1 and AIFM1. Interaction with SMAC hinders binding of TAB1/MAP3K7IP1 and AIFM1. Interacts with TCF25 and COMMD1. Interacts with SEPT4 isoform 6, but not with other SEPT4 isoforms. Interacts with RIP1, RIP2, RIP3, RIP4, CCS and USP19. Interacts (via BIR 2 domain and BIR 3 domain) with HAX1 (via C-terminus) and this interaction blocks ubiquitination of XIAP/BIRC4. Interacts with the monomeric form of BIRC5/survivin. Interacts with TLE3 and TCF7L2/TCF4.

    Three dimensional structures from OCA and Proteopedia for XIAP Gene

neXtProt entry for XIAP Gene

Proteomics data for XIAP Gene at MOPED

Post-translational modifications for XIAP Gene

  • Autoubiquitinated and degraded by the proteasome in apoptotic cells.
  • Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation.
  • S-Nitrosylation down-regulates its E3 ubiquitin-protein ligase activity.
  • Ubiquitination at Lys 10, Lys 31, Lys 116, Lys 168, Lys 208, Lys 322, and Lys 328
  • Modification sites at PhosphoSitePlus

Other Protein References for XIAP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for XIAP (XIAP)

No data available for DME Specific Peptides for XIAP Gene

Domains & Families for XIAP Gene

Gene Families for XIAP Gene

Protein Domains for XIAP Gene

Suggested Antigen Peptide Sequences for XIAP Gene

Graphical View of Domain Structure for InterPro Entry

P98170

UniProtKB/Swiss-Prot:

XIAP_HUMAN :
  • The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit CASP3 and CASP7, while the third BIR is involved in CASP9 inhibition. The interactions with DIABLO/SMAC and PRSS25 are mediated by the second and third BIR domains
  • Belongs to the IAP family.
  • Contains 3 BIR repeats.
Domain:
  • The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit CASP3 and CASP7, while the third BIR is involved in CASP9 inhibition. The interactions with DIABLO/SMAC and PRSS25 are mediated by the second and third BIR domains
Family:
  • Belongs to the IAP family.
Similarity:
  • Contains 3 BIR repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with XIAP: view

Function for XIAP Gene

Molecular function for XIAP Gene

UniProtKB/Swiss-Prot Function:
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

Enzyme Numbers (IUBMB) for XIAP Gene

Gene Ontology (GO) - Molecular Function for XIAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 19473982
GO:0005515 protein binding IPI 11257230
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 9230442
genes like me logo Genes that share ontologies with XIAP: view
genes like me logo Genes that share phenotypes with XIAP: view

Animal Models for XIAP Gene

MGI Knock Outs for XIAP:

Animal Model Products

miRNA for XIAP Gene

miRTarBase miRNAs that target XIAP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XIAP

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for XIAP Gene

Localization for XIAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for XIAP Gene

Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XIAP Gene COMPARTMENTS Subcellular localization image for XIAP gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 3
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for XIAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22304967
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15665297
GO:0005829 cytosol TAS --
GO:0005876 NOT spindle microtubule IBA --
genes like me logo Genes that share ontologies with XIAP: view

Pathways & Interactions for XIAP Gene

genes like me logo Genes that share pathways with XIAP: view

PCR Array Products

SIGNOR curated interactions for XIAP Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for XIAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0006974 cellular response to DNA damage stimulus IEP 18049476
GO:0012501 programmed cell death TAS --
GO:0016055 Wnt signaling pathway IEA --
GO:0016567 protein ubiquitination IDA 19473982
genes like me logo Genes that share ontologies with XIAP: view

Drugs & Compounds for XIAP Gene

(60) Drugs for XIAP Gene - From: NovoSeek, DGIdb, ApexBio, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitomycin Approved Pharma Inhibits DNA synthesis,antibiotic and antitumor agent 0
Bortezomib Approved, Experimental, Investigational Pharma Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1812
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Cytarabine Approved, Investigational Pharma 995

(41) Additional Compounds for XIAP Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AEG 40730 dihydrochloride
AZD 5582 dihydrochloride
UC 112
383392-66-3
2-Chlorodeoxyadenosine
5fluorouracil
genes like me logo Genes that share compounds with XIAP: view

Drug Products

Transcripts for XIAP Gene

Unigene Clusters for XIAP Gene

X-linked inhibitor of apoptosis:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XIAP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XIAP Gene

No ASD Table

Relevant External Links for XIAP Gene

GeneLoc Exon Structure for
XIAP
ECgene alternative splicing isoforms for
XIAP

Expression for XIAP Gene

mRNA expression in normal human tissues for XIAP Gene

Protein differential expression in normal tissues from HIPED for XIAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.7) and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for XIAP Gene



SOURCE GeneReport for Unigene cluster for XIAP Gene Hs.356076

mRNA Expression by UniProt/SwissProt for XIAP Gene

P98170-XIAP_HUMAN
Tissue specificity: Ubiquitous, except peripheral blood leukocytes
genes like me logo Genes that share expression patterns with XIAP: view

Protein tissue co-expression partners for XIAP Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for XIAP Gene

Orthologs for XIAP Gene

This gene was present in the common ancestor of animals.

Orthologs for XIAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XIAP 35
  • 91.75 (n)
  • 87.73 (a)
XIAP 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia XIAP 35
  • 91.14 (n)
  • 87.42 (a)
BIRC4 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Xiap 35
  • 90.05 (n)
  • 89.52 (a)
Xiap 16
Xiap 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia XIAP 35
  • 98.93 (n)
  • 98.39 (a)
XIAP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xiap 35
  • 89.78 (n)
  • 89.92 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves XIAP 35
  • 66.67 (n)
  • 59.18 (a)
IAP3 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia xiap 35
  • 61.71 (n)
  • 53.02 (a)
zebrafish
(Danio rerio)
Actinopterygii xiap 35
  • 55.56 (n)
  • 51.06 (a)
xiap 36
  • 42 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4242 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012677 35
  • 52.07 (n)
  • 42.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta Iap2 36
  • 30 (a)
ManyToMany
th 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for XIAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XIAP Gene

ENSEMBL:
Gene Tree for XIAP (if available)
TreeFam:
Gene Tree for XIAP (if available)

Paralogs for XIAP Gene

Paralogs for XIAP Gene

(4) SIMAP similar genes for XIAP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for XIAP Gene

genes like me logo Genes that share paralogs with XIAP: view

Variants for XIAP Gene

Sequence variations from dbSNP and Humsavar for XIAP Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs8371 -- 123,912,065(+) AACTA(C/T)TCTTT utr-variant-3-prime, nc-transcript-variant
rs9856 -- 123,911,791(+) CACTT(C/T)AATAA utr-variant-3-prime, nc-transcript-variant
rs1474593 -- 123,861,754(+) ATATA(C/T)GTATT intron-variant
rs1474594 -- 123,861,867(+) ATTGC(C/T)CTCTC intron-variant
rs1535222 -- 123,895,291(+) ctttt(C/T)tattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XIAP Gene

Variant ID Type Subtype PubMed ID
dgv2471e1 CNV Complex 17122850
nsv507991 CNV Insertion 20534489

Variation tolerance for XIAP Gene

Residual Variation Intolerance Score: 69.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XIAP Gene

HapMap Linkage Disequilibrium report
XIAP
Human Gene Mutation Database (HGMD)
XIAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XIAP Gene

Disorders for XIAP Gene

MalaCards: The human disease database

(18) MalaCards diseases for XIAP Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
lymphoproliferative syndrome, x-linked, 2
  • x-linked lymphoproliferative syndrome 2
lymphoproliferative syndrome, x-linked, 1
  • lymphoproliferative syndrome, x-linked
thymic hyperplasia
  • hyperplasia of thymus gland
dysgammaglobulinemia
cowpox
  • yaba
- elite association
Search XIAP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

XIAP_HUMAN
  • Lymphoproliferative syndrome, X-linked, 2 (XLP2) [MIM:300635]: A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma. {ECO:0000269 PubMed:17080092}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for XIAP

Genetic Association Database (GAD)
XIAP
Human Genome Epidemiology (HuGE) Navigator
XIAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XIAP
genes like me logo Genes that share disorders with XIAP: view

No data available for Genatlas for XIAP Gene

Publications for XIAP Gene

  1. AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression. (PMID: 19726736) Straszewski-Chavez S.L. … Mor G. (Biol. Reprod. 2010) 23 67
  2. Lead affects apoptosis and related gene XIAP and Smac expression in the hippocampus of developing rats. (PMID: 19911273) Liu J. … Huo X. (Neurochem. Res. 2010) 23 67
  3. The time course of Akt and ERK activation on XIAP expression in HEK 293 cell line. (PMID: 19649722) Abkhezr M. … Ghahremani M.H. (Mol. Biol. Rep. 2010) 23 67
  4. XIAP-mediated protection of H460 lung cancer cells against cisplatin. (PMID: 19903469) Cheng Y.J. … Hsueh C.M. (Eur. J. Pharmacol. 2010) 23 67
  5. A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC. (PMID: 19904270) Dean E.J. … Dive C. (Br. J. Cancer 2010) 23 67

Products for XIAP Gene

  • Addgene plasmids for XIAP

Sources for XIAP Gene

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