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XG Gene

protein-coding   GIFtS: 50

GC0XP002663
Xg blood group
(Previous name: Xg blood group (pseudoautosomal boundary-divided on the X chromosome) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PBDX)
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Aliases &
Descriptions
for XG

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC118758 2
MGC118759 2
MGC118760 2
MGC118761 2
OTTHUMP00000022846 2
PBDX 2, 3
Descriptions
Protein PBDX 3
XG glycoprotein 2
Xg blood group 2
Xg blood group (pseudoautosomal boundary-divided on the X
chromosome) 1, 2
External Ids
HGNC: 128061
Entrez Gene: 74992
UniProtKB: P558083
Ensembl: ENSG000001243437
Search outside databases for aliases for XG gene

Previous GC identifers: GC0XU990234 GC0XM001839 GC0XP002200 GC0XP002265

Summaries
for XG

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for XG:
This gene encodes the XG blood group antigen, and is located at the pseudoautosomal boundary on the
short (p) arm of chromosome X. The three 5' exons reside in the pseudoautosomal region and
the remaining exons within the X-specific end. A truncated copy of this gene is found on the Y
chromosome at the pseudoautosomal boundary. It is transcribed, but not expected to make a
Y-chromosome specific gene product. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq]

Genomic Location
for XG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the XG gene  

Entrez Gene cytogenetic band: Xp22.33   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.32

XG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP002663:     (about GC identifiers)

Start:
 2,680,115 bp from pter
End:
 2,743,968 bp from pter
Size:
 63,854 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011757.15  

Proteins
for XG

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: XG_HUMAN, P55808 (See protein sequence)
Recommended Name: Glycoprotein Xg precursor  
Size: 180 amino acids; 19723 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1)
of X and Y chromosomes
Caution: Ref.3 sequence incorrectly indicated as originating from mouse
Secondary accessions: Q496N8 Q496N9 Q496P0 Q71BZ5
Alternative splicing: 3 isoforms:  P55808-1   P55808-2   P55808-3   

Post-translational modifications:

  • O-glycosylated (Probable)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001135391.1  NP_001135392.1  NP_780778.1  


    ENSEMBL proteins: 
    ENSP00000370564 ENSP00000370566 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Xg blood group)
    Human Recombinant Proteins from Abnova (XG)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane NAS--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for XG: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for XG
    R&D Systems Antibodies for XG
    Antibodies from Abcam (Xg blood group), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (XG)
    Novus Biologicals Antibody for XG

    Assays for XG: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for XG

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P55808

    UniProtKB/Swiss-Prot: XG_HUMAN, P55808
    Similarity: Belongs to the CD99 family

    Gene Function
    for XG

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (XG)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001141919

                  Applied Biosystems Silencer® siRNAs for XG

                  Sigma-Aldrich siRNA for XG  
                         Sigma-Aldrich shRNA for XG  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for XG
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001141919
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001141919
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001141919 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001141919

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674 molecular_function ND8054981
    About this table

    Pathways & Interactions
    for XG

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  XG 


    5/12 Interacting proteins for XG (ENSP000003705643) via UniProtKB, MINT, and/or STRING (see all 12 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD99ENSP000003705883STRING (score=.967)
    G6PDENSP000002915673STRING (score=.954)
    STSENSP000002179613STRING (score=.938)
    HPRT1ENSP000002985563STRING (score=.898)
    XKENSP000003678793STRING (score=.871)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150 biological_process ND--
    About this table

    Drugs & Compounds
    for XG

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XG

    Transcripts
    for XG

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (XG)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001141919

                  Sigma-Aldrich siRNA for XG  
                         Sigma-Aldrich shRNA for XG  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001141919  NM_001141920  NM_175569  

    REFSEQ mRNAs for XG gene (3 alternative transcripts): 

    NM_001141919.1   NM_001141920.1   NM_175569.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001141919  NM_001141920  NM_175569  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001141919
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001141919
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001141919 

    Additional cDNA sequence: 

    AF380356.1 AK304164.1 BC100764.2 BC100765.2 BC100766.2 BC100767.1 Z48517.1 Z48518.1 
    Z48519.1 

    14 DOTS entries:

    DT.97835036  DT.121282475  DT.300477  DT.95133671  DT.121282487  DT.431733  DT.121282484  DT.100643907 
    DT.121282478  DT.40258841  DT.120652297  DT.308496  DT.91918877  DT.97782142 

    24/40 AceView cDNA sequences (see all 40 ):

    BF515810 CA390062 CD172101 BX098030 NM_175569 BX403244 AI183456 BX379565 
    T96594 BU626184 BF718591 AW369156 AF380356 BX107166 BM723344 AW449679 
    AI168338 AA336889 Z48518 BQ014345 BF507402 H63758 BF109681 BM682207 

    highest scoring ESTs for XG:

    AI379476 AI183456 AW449679 BF515810 BF718591 BM987280 BQ005371 BQ014345 BX107166 CA390062 

    Unigene Cluster for XG:

    Xg blood group
    Hs.179675  [show with all ESTs]
    Unigene Representative Sequence: NM_001141919


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000381172  ENST00000381174  

    Expression
    for XG

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XG expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XG

    1 / 2 / 3

    5 probe-sets matching XG gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		84971_at2, 3 U95-E 1 1.00 1.00 0.71 1.20 AI168338 0.40 1.00 0.76 1

    		91492_at2, 3 U95-D 2 1.00 0.81 0.66 0.85 AI379476 1.00 1.00 1.00 1

    		241931_at2, 3 U133-B 1 1.00 1.00 -- -- AI168338 0.40 1.00 0.76 1

    		241931_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1554062_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.179675

    Orthologs
    for XG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for XG gene from 1 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    cow
    (Bos taurus)    		 XG1   -- Xg blood group 68.96(n)
    63.36(a)    		 515234  XM_611572.3  XP_611572.3 
    About this table        Species with no ortholog for XG

    ENSEMBL Gene Tree for XG

    Paralogs
    for XG

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for XG

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		UniProtKB/Swiss-Prot: XG_HUMAN, P55808
    Polymorphism: XG is responsible for the Xg blood group system


    10/15423 NCBI SNPs in XG are shown (see all 15423 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 24)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs36721,2
    		A,C,F,H2743641(-) CACATT/CTGAGA 1 -- ut31 ese35Minor allele frequency- C:0.46EU EA WA MN 602
    --
    rs36711,2
    		C,F,H,O2743668(-) TCAAAT/CTGCAC 1 -- ut315Minor allele frequency- C:0.20EU EA WA MN 602
    rs59393191,2
    		C,F,H2710157(+) ATCCCG/AACAGC 1 N/D mis1 ese312Minor allele frequency- A:0.04EU EA WA NA 846
    --
    rs59391241,2
    		A,C,F2743109(+) GGAAAG/TCATAT 1 -- ut314Minor allele frequency- T:0.30EA NA 214
    --
    rs59393391,2
    		C,F2743276(+) AGGAAA/GTCTTA 1 -- ut313Minor allele frequency- G:0.09NA 142
    --
    rs59391251,2
    		A,C2743210(+) TAAGTA/GCTAGT 1 -- ut310--------
    --
    rs128449271,2
    		H2742526(+) ATGACC/TTAAAG 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 412
    --
    rs126884881,2
    		H2743617(+) CATTAG/AGTACC 1 -- ut314Minor allele frequency- A:0.00EU EA WA 418
    --
    rs128508001,2
    		H2742563(+) GAGCTG/TCCTCA 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 420
    --
    rs128449601,2
    		H2742564(+) AGCTGC/TCTCAC 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for XG (up to first 250kb)

    Disorders & Mutations
    for XG

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 314700

    Genatlas disease: XG
    Xg blood group

    Blood Group Antigen Gene Mutation Database (BGMUT) Xg blood group system 

    Medical News
    for XG

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for XG

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		9 PubMed articles for XG gene:

    Search for XG

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing XG

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 7499 HGNC: 12806 AceView: XG Ensembl:ENSG00000124343 euGenes: HUgn7499
    ECgene: XG H-InvDB: XG

    Other Databases showing XG

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing XG

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=xg

    Licensable Technologies
    for XG

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for XG

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XG:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XG-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for XG Antibodies for XG
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for XG Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (XG)
     Antibodies (XG)
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Xg blood group)
     Antibodies (Xg blood group)
     Search OriGene for XG
     Search Tocris compounds for XG




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for XG

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