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XCR1 Gene

protein-coding   GIFtS: 59
GCID: GC03M046037

Chemokine (C Motif) Receptor 1

(Previous name: chemokine (C motif) XC receptor 1)
(Previous symbols: GPR5, CCXCR1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C Motif) Receptor 11 2     G-Protein Coupled Receptor 52 3
CCXCR11 2 3 5     XC Chemokine Receptor 12 3
GPR51 2 3 5     Chemokine XC Receptor 12
Chemokine (C Motif) XC Receptor 11 2     G Protein-Coupled Receptor 52
Lymphotactin Receptor2 3     

External Ids:    HGNC: 16251   Entrez Gene: 28292   Ensembl: ENSG000001735787   OMIM: 6005525   UniProtKB: P460943   

Export aliases for XCR1 gene to outside databases

Previous GC identifers: GC03M045303 GC03M045881 GC03M046023


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XCR1 Gene:
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily.
The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino
acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal
by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist
of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for XCR1 Gene:
XCR1 (chemokine (C motif) receptor 1) is a protein-coding gene. GO annotations related to this gene include chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: XCR1_HUMAN, P46094
Function: Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the
intracellular calcium ions level

Gene Wiki entry for XCR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the XCR1 gene promoter:
         AP-1   HSF1 (long)   MIF-1   POU3F2   GATA-1   Meis-1b   IRF-2   HSF1short   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXCR1 promoter sequence
   Search Chromatin IP Primers for XCR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3-p21.1

XCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XCR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M046037:  view genomic region     (about GC identifiers)

Start:
46,058,516 bp from pter      End:
46,069,234 bp from pter
Size:
10,719 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: XCR1_HUMAN, P46094 (See protein sequence)
Recommended Name: Chemokine XC receptor 1  
Size: 333 amino acids; 38508 Da

Explore the universe of human proteins at neXtProt for XCR1: NX_P46094

Explore proteomics data for XCR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See XCR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019815.1  NP_005274.1  

    ENSEMBL proteins: 
     ENSP00000310405   ENSP00000379277   ENSP00000438119  
    Reactome Protein details: P46094

    XCR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for XCR1

     
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    Search eBioscience for ELISAs for XCR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    XCR: GPCR / Class A : Chemokine receptors : X-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: XCR1
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005393 Chemokine_XCR1
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P46094

    ProtoNet protein and cluster: P46094

    1 Blocks protein domain: IPB005393 Lymphotactin receptor signature

    UniProtKB/Swiss-Prot: XCR1_HUMAN, P46094
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with XCR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XCR1_HUMAN, P46094
    Function: Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the
    intracellular calcium ions level

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity IEA--
         
    Find genes that share ontologies with XCR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for XCR1:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Xcr1):
     hematopoietic system  immune system  normal 

    Find genes that share phenotypes with XCR1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XCR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for XCR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XCR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XCR1

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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat XCR1

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    GenScript: all cDNA clones in your preferred vector (see all 2): XCR1 (NM_005283)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XCR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XCR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XCR1_HUMAN, P46094: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9632725
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with XCR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for XCR1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with XCR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for XCR1
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for XCR1 (see all 7)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling

    1 BioSystems Pathway for XCR1
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for XCR1
        Chemokine receptors bind chemokines
    G alpha (q) signalling events


    2 Kegg Pathways  (Kegg details for XCR1):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including XCR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for XCR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for XCR1 (P460943 ENSP000003104054) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XCL1P479923, ENSP000003567924I2D: score=1 STRING: ENSP00000356792
    XCL2Q9UBD33, ENSP000003567934I2D: score=1 STRING: ENSP00000356793
    AGTR1ENSP000002734304STRING: ENSP00000273430
    LTB4RENSP000003074454STRING: ENSP00000307445
    NTSR2ENSP000003036864STRING: ENSP00000303686
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response TAS9632725
    GO:0007186G-protein coupled receptor signaling pathway TAS10679309
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS9632725
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS9632725

    Find genes that share ontologies with XCR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for XCR1

    1 HMDB Compound for XCR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 IUPHAR Ligands for XCR1 (XCR1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]XCL1
    AgonistFull agonist89632725
    XCL1
    AgonistFull agonist8--
    XCL2
    AgonistAgonist8--
    SEAP-XCL1
    AgonistFull agonist8--

    1 Novoseek inferred chemical compound relationship for XCR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 10.3 2 17302442 (1), 17403668 (1)



    Find genes that share compounds with XCR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for XCR1 gene (2 alternative transcripts): 
    NM_001024644.1  NM_005283.2  

    Unigene Cluster for XCR1:

    Chemokine (C motif) receptor 1
    Hs.248116  [show with all ESTs]
    Unigene Representative Sequence: NM_005283
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309285(uc003cpf.3) ENST00000395946 ENST00000542109(uc003cpe.3)

    miRNA
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    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat XCR1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): XCR1 (NM_005283)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for XCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XCR1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat XCR1
      QuantiFast Probe-based Assays in human, mouse, rat XCR1

    Additional mRNA sequence: 

    AB189434.1 AB189435.1 AK314277.1 BC069075.1 BC069589.1 BC095533.1 

    2 DOTS entries:

    DT.120846457  DT.102819653 

    6 AceView cDNA sequences:

    NM_005283 BC069589 AB189435 BC069075 AB189434 CF147783 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    XCR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGCGGG
    XCR1 Expression
    About this image


    XCR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    XCR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    XCR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248116
        Pathway & Disease-focused RT2 Profiler PCR Arrays including XCR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for XCR1
    OriGene qSTAR qPCR primer pairs in human, mouse for XCR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat XCR1
    QuantiTect SYBR Green Assays in human, mouse, rat XCR1
    QuantiFast Probe-based Assays in human, mouse, rat XCR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XCR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for XCR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Xcr11 , 5 chemokine (C motif) receptor 11, 5 76.07(n)1
    72.41(a)1
      9 (74.71 cM)5
    238321  NM_011798.41  NP_035928.21 
     1238523155 
    chicken
    (Gallus gallus)
    Aves XCR11 chemokine (C motif) receptor 1 57.56(n)
    53.73(a)
      428452  NM_001045838.1  NP_001039303.1 
    lizard
    (Anolis carolinensis)
    Reptilia XCR16
    chemokine (C motif) receptor 1
    45(a)
    1 ↔ 1
    GL343324.1(392617-393651)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia xcr11 chemokine (C motif) receptor 1 52.94(n)
    45.6(a)
      100491542  XM_002933411.2  XP_002933457.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003297961 chemokine XC receptor 1-like 55.13(n)
    42.86(a)
      100329796  XM_002667383.3  XP_002667429.1 


    ENSEMBL Gene Tree for XCR1 (if available)
    TreeFam Gene Tree for XCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for XCR1 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  CCR92  CCRL22  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for XCR1 using alignment to 3 protein entries:     XCR1_HUMAN (see all proteins) (see all similar genes):
    CMKLR1    CCR8    CCR3    CCR4    CX3CR1    CXCR2
    IL8RB    CCR2    CCR1    CCR5    CCR-5    CXCR4
    ACKR2    CCBP2    CCR6    CXCR1    CXCR6    ACKR4

    Find genes that share paralogs with XCR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for XCR1 (see all 201)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130743821,2
    C,F,A,H--46061840(+) ACTTGA/GATCCA 2 -- ds500122Minor allele frequency- G:0.22NS EA NA WA CSA 2350
    rs130975561,2
    C,F--46061997(+) GTGAAT/CAAACC 2 -- ds500113Minor allele frequency- C:0.20NA EA WA CSA 732
    rs755207081,2
    F--46062086(+) CCTGTA/TAAGTC 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs803015971,2
    F--46062182(+) GGAGCG/ATGCAA 2 -- ds50011Minor allele frequency- A:0.01EA 120
    rs779592511,2
    F--46062196(+) GAACTC/GAGAGT 2 -- ds50011Minor allele frequency- G:0.01EA 120
    rs1159328961,2
    C,F--46062389(+) CCCCCA/GTTCCA 2 -- ut311Minor allele frequency- G:0.02WA 118
    rs76509681,2
    C,F,H--46062402(+) CCCTGT/GCCACC 2 -- ut31 ese35Minor allele frequency- G:0.01NS NA 584
    rs1386416091,2
    C--46062425(+) TGCACC/TGCCAC 2 -- ut310--------
    rs2018196671,2
    --46062430(+) CGCCAA/CAGGCC 2 -- ut310--------
    rs1488788871,2
    C,F--46062453(+) GAGGCG/ACCCTC 4 /G syn11Minor allele frequency- A:0.00NA 4078

    HapMap Linkage Disequilibrium report for XCR1 (46058516 - 46069234 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for XCR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876734CNV Gain21882294
    dgv1453e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing XCR1
    DNA2.0 Custom Variant and Variant Library Synthesis for XCR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600552    OMIM disorders: --


    Find genes that share disorders with XCR1           About GenesLikeMe

    Genetic Association Database (GAD): XCR1
    Human Genome Epidemiology (HuGE) Navigator: XCR1 (3 documents)

    Export disorders for XCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for XCR1 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with XCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of three novel human genes encoding G protein-coupled receptors. (PubMed id 7832990)1, 2, 3, 9 Heiber M.... O'Dowd B.F. (DNA Cell Biol. 1995)
    2. Identification of single C motif-1/lymphotactin receptor XCR1. (PubMed id 9632725)1, 2, 9 Yoshida T.... Yoshie O. (J. Biol. Chem. 1998)
    3. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PubMed id 17135764)1, 4 Nakamura H....Eboshida A. (Int. Arch. Allergy Immunol. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Intracellular signalling pathways induced by chemokines in natural killer cells. (PubMed id 10400311)1, 3 Maghazachi A.A. (Cell. Signal. 1999)
    6. The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor. (PubMed id 18426556)1, 9 LA1ttichau H.R. (Virol. J. 2008)
    7. Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. (PubMed id 17403668)1, 9 LA1ttichau H.R....Schwartz T.W. (J. Biol. Chem. 2007)
    8. Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo. (PubMed id 11446740)1, 9 Kurt R.A....Urba W.J. (Cell. Immunol. 2001)
    9. The lymphotactin receptor is expressed in epithelial ovarian carcinoma and contributes to cell migration and proliferation. (PubMed id 22964431)1 Kim M....Barbolina M.V. (Mol. Cancer Res. 2012)
    10. Genetic variation in I+-synuclein kinases (CK-2I^ and GRK-5) and risk of Parkinson's disease. (PubMed id 21514207)1 GarcA-a-Gorostiaga I....Infante J. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2829 HGNC: 1625 AceView: XCR1 Ensembl:ENSG00000173578 euGenes: HUgn2829
    ECgene: XCR1 Kegg: 2829 H-InvDB: XCR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for XCR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for XCR1 gene:
    Search GeneIP for patents involving XCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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