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Aliases for XCR1 Gene

Aliases for XCR1 Gene

  • Chemokine (C Motif) Receptor 1 2 3
  • Chemokine (C Motif) XC Receptor 1 2 3
  • G-Protein Coupled Receptor 5 3 4
  • XC Chemokine Receptor 1 3 4
  • Lymphotactin Receptor 3 4
  • CCXCR1 3 4
  • GPR5 3 4
  • G Protein-Coupled Receptor 5 3

External Ids for XCR1 Gene

Previous HGNC Symbols for XCR1 Gene

  • GPR5
  • CCXCR1

Previous GeneCards Identifiers for XCR1 Gene

  • GC03M045303
  • GC03M045881
  • GC03M046023

Summaries for XCR1 Gene

Entrez Gene Summary for XCR1 Gene

  • The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for XCR1 Gene

XCR1 (Chemokine (C Motif) Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for XCR1 Gene

  • Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level

Gene Wiki entry for XCR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XCR1 Gene

Genomics for XCR1 Gene

Regulatory Elements for XCR1 Gene

Genomic Location for XCR1 Gene

Chromosome:
3
Start:
46,017,024 bp from pter
End:
46,027,742 bp from pter
Size:
10,719 bases
Orientation:
Minus strand

Genomic View for XCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for XCR1 Gene

Proteins for XCR1 Gene

  • Protein details for XCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46094-XCR1_HUMAN
    Recommended name:
    Chemokine XC receptor 1
    Protein Accession:
    P46094

    Protein attributes for XCR1 Gene

    Size:
    333 amino acids
    Molecular mass:
    38508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XCR1 Gene

Proteomics data for XCR1 Gene at MOPED

Post-translational modifications for XCR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for XCR1 Gene

Domains & Families for XCR1 Gene

Gene Families for XCR1 Gene

Protein Domains for XCR1 Gene

Suggested Antigen Peptide Sequences for XCR1 Gene

Graphical View of Domain Structure for InterPro Entry

P46094

UniProtKB/Swiss-Prot:

XCR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with XCR1: view

Function for XCR1 Gene

Molecular function for XCR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level

Gene Ontology (GO) - Molecular Function for XCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with XCR1: view
genes like me logo Genes that share phenotypes with XCR1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XCR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for XCR1 Gene

Localization for XCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XCR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XCR1 Gene COMPARTMENTS Subcellular localization image for XCR1 gene
Compartment Confidence
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for XCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS 9632725
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9632725
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with XCR1: view

Pathways & Interactions for XCR1 Gene

genes like me logo Genes that share pathways with XCR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for XCR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for XCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response TAS 9632725
GO:0007186 G-protein coupled receptor signaling pathway TAS 10679309
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 9632725
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 9632725
genes like me logo Genes that share ontologies with XCR1: view

Drugs & Compounds for XCR1 Gene

(4) Drugs for XCR1 Gene - From: DGIdb, IUPHAR, NovoSeek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
XCL1 Pharma Full agonist, Agonist 0
XCL2 Pharma Agonist 0
Calcium Nutra 0
[<SUP>125</SUP>I]XCL1 (HUMAN) Pharma 0

(2) Additional Compounds for XCR1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]XCL1
Full agonist, Agonist
SEAP-XCL1
Full agonist, Agonist
genes like me logo Genes that share compounds with XCR1: view

Transcripts for XCR1 Gene

mRNA/cDNA for XCR1 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XCR1 Gene

Chemokine (C motif) receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XCR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XCR1 Gene

No ASD Table

Relevant External Links for XCR1 Gene

GeneLoc Exon Structure for
XCR1
ECgene alternative splicing isoforms for
XCR1

Expression for XCR1 Gene

mRNA expression in normal human tissues for XCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XCR1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x10.7), Skin - Not Sun Exposed (Suprapubic) (x9.4), Spleen (x7.1), and Whole Blood (x6.1).

SOURCE GeneReport for Unigene cluster for XCR1 Gene Hs.248116

genes like me logo Genes that share expression patterns with XCR1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for XCR1 Gene

Orthologs for XCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XCR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XCR1 35
  • 83.98 (n)
  • 78.08 (a)
XCR1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XCR1 35
  • 83.54 (n)
  • 78.48 (a)
XCR1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xcr1 35
  • 76.07 (n)
  • 72.41 (a)
Xcr1 16
Xcr1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XCR1 35
  • 99.5 (n)
  • 99.7 (a)
XCR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xcr1 35
  • 77.6 (n)
  • 70.94 (a)
oppossum
(Monodelphis domestica)
Mammalia XCR1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XCR1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves XCR1 35
  • 57.56 (n)
  • 53.73 (a)
CCXCR1-L 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XCR1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xcr1 35
  • 52.94 (n)
  • 45.6 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100329796 35
  • 55.13 (n)
  • 42.86 (a)
XCR1 (1 of 4) 36
  • 38 (a)
OneToMany
XCR1 (2 of 4) 36
  • 35 (a)
OneToMany
XCR1 (4 of 4) 36
  • 37 (a)
OneToMany
xcr1a 36
  • 39 (a)
OneToMany
Species with no ortholog for XCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XCR1 Gene

ENSEMBL:
Gene Tree for XCR1 (if available)
TreeFam:
Gene Tree for XCR1 (if available)

Paralogs for XCR1 Gene

genes like me logo Genes that share paralogs with XCR1: view

Variants for XCR1 Gene

Sequence variations from dbSNP and Humsavar for XCR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2371 -- 46,027,727(+) ACTCC(A/G)TGAAT upstream-variant-2KB
rs876668 -- 46,022,261(-) gtggc(A/G)tgatc intron-variant, utr-variant-5-prime
rs1392289 -- 46,027,646(+) cttca(A/G)accaa upstream-variant-2KB
rs1392290 -- 46,027,718(+) GAAAC(A/G)CCTAC upstream-variant-2KB
rs2230322 -- 46,021,837(-) GTCCT(A/G)TACTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for XCR1 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294
dgv1453e1 CNV Complex 17122850

Variation tolerance for XCR1 Gene

Residual Variation Intolerance Score: 61.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for XCR1 Gene

HapMap Linkage Disequilibrium report
XCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XCR1 Gene

Disorders for XCR1 Gene

Relevant External Links for XCR1

Genetic Association Database (GAD)
XCR1
Human Genome Epidemiology (HuGE) Navigator
XCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XCR1
genes like me logo Genes that share disorders with XCR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XCR1 Gene

Publications for XCR1 Gene

  1. Isolation of three novel human genes encoding G protein-coupled receptors. (PMID: 7832990) Heiber M. … O'Dowd B.F. (DNA Cell Biol. 1995) 2 23 67
  2. Functional expression of the chemokine receptor XCR1 on oral epithelial cells. (PMID: 20225245) Khurram S.A. … Farthing P.M. (J. Pathol. 2010) 23 67
  3. Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. (PMID: 19652364) Jin G. … Wang T.C. (J. Clin. Invest. 2009) 23 67
  4. The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor. (PMID: 18426556) LA1ttichau H.R. (Virol. J. 2008) 23 67
  5. Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. (PMID: 17403668) LA1ttichau H.R. … Schwartz T.W. (J. Biol. Chem. 2007) 23 67

Products for XCR1 Gene

Sources for XCR1 Gene

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