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Aliases & Descriptions for XCR1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CCXCR1 2 , 3 , 5 GPR5 2 , 3 , 5
Descriptions G protein-coupled receptor 5 2 G-protein coupled receptor 5 3 Lymphotactin receptor 2 , 3 XC chemokine receptor 1 2 , 3 chemokine (C motif) XC receptor 1 1 , 2 chemokine (C motif) receptor 1 2
Search outside databases for aliases for XCR1 genePrevious GC identifers: GC03M045303 GC03M045881 GC03M046023
Summaries for XCR1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for XCR1 : The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupledreceptor superfamily. The family members are characterized by the presence of 7 transmembranedomains and numerous conserved amino acids. This receptor is most closely related to RBS11 and theMIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ionslevel. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blockssignaling. Two alternatively spliced transcript variants encoding the same protein have been foundfor this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: XCR1_HUMAN, P46094 Function : Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasingthe intracellular calcium ions level
Gene Wiki entry for XCR1
Genomic Location for XCR1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the XCR1 gene Entrez Gene cytogenetic band: 3p21.3-p21.1|3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3-p21.1 XCR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M046037:
(about GC identifiers )
Start:
46,037,295 bp from pter
End:
46,043,983 bp from pter
Size:
6,689 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000003.10 NT_022517.17 Proteins for XCR1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: XCR1_HUMAN, P46094 (See
protein sequence )Recommended Name: Chemokine XC receptor 1 Size : 333 amino acids; 38508 Da
Subcellular location : Cell membrane; Multi-pass membrane protein
REFSEQ proteins (2 alternative transcripts):
NP_001019815.1 NP_005274.1 ENSEMBL proteins: ENSP00000379277 ENSP00000310405 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for XCR1: Assays for XCR1:
Protein
Domains/ Families for XCR1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P46094 ProtoNet protein and cluster: P46094
1 Blocks protein family : IPB005393 Lymphotactin receptor signature UniProtKB/Swiss-Prot: XCR1_HUMAN, P46094 Similarity : Belongs to the G-protein coupled receptor 1 family
Gene Function for XCR1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
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Sigma-Aldrich ,
RNAi Products ,
Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005283 Applied Biosystems Silencer ® siRNAs for XCR1 Sigma-Aldrich siRNA and siRNA Panels for XCR1 Sigma-Aldrich shRNA Panels and shRNA for XCR1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024644                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024644                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001024644  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005283 UniProtKB/Swiss-Prot: XCR1_HUMAN, P46094 Function : Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasingthe intracellular calcium ions level
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Xcr1) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for XCR1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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4 Interacting proteins for XCR1 (ENSP00000310405 3 ) via UniProtKB, MINT, and/or STRING About this table 5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
):
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Drugs & Compounds for XCR1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Compounds for XCR1 available from Tocris Bioscience 1 Novoseek chemical compound relationship for XCR1 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
calcium
14.78
2
17302442 (1), 17403668 (1)
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Transcripts for XCR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005283 Sigma-Aldrich siRNA and siRNA Panels for XCR1 Sigma-Aldrich shRNA Panels and shRNA for XCR1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001024644 NM_005283
REFSEQ mRNAs for XCR1 gene (2 alternative transcripts): NM_001024644.1 NM_005283.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001024644 NM_005283
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024644                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024644                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001024644  
Additional cDNA sequence: AB189434.1 AB189435.1 AK314277.1 BC069075.1 BC069589.1 BC095533.1
2 DOTS entries : DT.120846457 DT.102819653
6 AceView cDNA sequences :BC069589 BC069075 AB189434 NM_005283 AB189435 CF147783
highest scoring ESTs for XCR1 :AB189434 AB189435 BC069075 BC069589 CF147783 NM_005283 BC095533 DA847074 NM_001024644 CO959248
Unigene Cluster for XCR1: Chemokine (C motif) receptor 1 Hs.248116 [show with all ESTs ] Unigene Representative Sequence: NM_005283 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000395946
ENST00000309285
Expression for XCR1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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XCR1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for XCR1 1 / 2 / 3
2 probe-sets matching XCR1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAGAAGCGGGSOURCE GeneReport for Unigene cluster: Hs.248116
Orthologs for XCR1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for XCR1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for XCR1 ENSEMBL Gene Tree for XCR1 Paralogs for XCR1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for XCR1 gene CX3CR1 2 CCR8 2 CCBP2 2
SNPs/Variants for XCR1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for XCR1 (up to first 250kb)
Disorders & Mutations for XCR1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600552 Human Genome Epidemiology Navigator: XCR1 (1 document)
Medical News for XCR1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for XCR1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/16 PubMed articles for XCR1 gene (see all 16
): Isolation of three novel human genes encoding G protein-coupled receptors. (PubMed id 7832990) 1, 2, 3, 4 Heiber M.... O'Dowd B.F. (1995) Identification of single C motif-1/lymphotactin receptor XCR1. (PubMed id 9632725) 1, 3, 4 Yoshida T.... Yoshie O. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Intracellular signalling pathways induced by chemokines in natural killer cells. (PubMed id 10400311) 2, 3 Maghazachi A.A. (1999) The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor. (PubMed id 18426556) 1, 3 Luttichau H.R. (2008) Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. (PubMed id 17403668) 1, 3 Luttichau H.R....Schwartz T.W. (2007) Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo. (PubMed id 11446740) 1, 3 Kurt R.A....Urba W.J. (2001) Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PubMed id 17135764) 3 Nakamura H....Eboshida A. (2007) Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1. (PubMed id 15777643) 3 Shinkai H....Uenishi H. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing XCR1
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing XCR1
(According to HUGE )
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Specialized Databases showing XCR1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for XCR1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for XCR1:
Tocris compounds for XCR1
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