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Aliases for XCL2 Gene

Aliases for XCL2 Gene

  • Chemokine (C Motif) Ligand 2 2 3
  • SCYC2 3 4 6
  • Small Inducible Cytokine Subfamily C, Member 2 2 3
  • XC Chemokine Ligand 2 3 4
  • C Motif Chemokine 2 3 4
  • SCM1B 3 6
  • Cytokine SCM-1 Beta 3
  • SCM-1b 3
  • XCL2 6

External Ids for XCL2 Gene

Previous Symbols for XCL2 Gene

  • SCYC2

Summaries for XCL2 Gene

GeneCards Summary for XCL2 Gene

XCL2 (Chemokine (C Motif) Ligand 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include chemokine activity. An important paralog of this gene is XCL1.

UniProtKB/Swiss-Prot for XCL2 Gene

  • Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XCL2 Gene

Genomics for XCL2 Gene

Genomic Location for XCL2 Gene

168,540,765 bp from pter
168,543,997 bp from pter
3,233 bases
Minus strand

Genomic View for XCL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XCL2 Gene

Regulatory Elements for XCL2 Gene

Proteins for XCL2 Gene

  • Protein details for XCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytokine SCM-1 beta
    Protein Accession:
    Secondary Accessions:

    Protein attributes for XCL2 Gene

    114 amino acids
    Molecular mass:
    12567 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XCL2 Gene

Proteomics data for XCL2 Gene at MOPED

Post-translational modifications for XCL2 Gene

No Post-translational modifications

Other Protein References for XCL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for XCL2 Gene

Domains for XCL2 Gene

Gene Families for XCL2 Gene


Protein Domains for XCL2 Gene

Suggested Antigen Peptide Sequences for XCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine gamma family.:
    • Q9UBD3
genes like me logo Genes that share domains with XCL2: view

Function for XCL2 Gene

Molecular function for XCL2 Gene

UniProtKB/Swiss-Prot Function: Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

Gene Ontology (GO) - Molecular Function for XCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with XCL2: view

Phenotypes for XCL2 Gene

GenomeRNAi human phenotypes for XCL2:
genes like me logo Genes that share phenotypes with XCL2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XCL2 Gene

Localization for XCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XCL2 Gene


Subcellular locations from

Jensen Localization Image for XCL2 Gene COMPARTMENTS Subcellular localization image for XCL2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for XCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with XCL2: view

Pathways for XCL2 Gene

genes like me logo Genes that share pathways with XCL2: view

Gene Ontology (GO) - Biological Process for XCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 7875320
GO:0008015 blood circulation TAS 7875320
GO:0060326 cell chemotaxis TAS 7875320
genes like me logo Genes that share ontologies with XCL2: view

Transcripts for XCL2 Gene

mRNA/cDNA for XCL2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XCL2 Gene

Chemokine (C motif) ligand 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XCL2 Gene

No ASD Table

Relevant External Links for XCL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XCL2 Gene

mRNA expression in normal human tissues for XCL2 Gene

mRNA differential expression in normal tissues according to GTEx for XCL2 Gene

This gene is overexpressed in Whole Blood (22.7) and Spleen (10.7).

SOURCE GeneReport for Unigene cluster for XCL2 Gene Hs.458346

genes like me logo Genes that share expressions with XCL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for XCL2 Gene

Orthologs for XCL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XCL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
-- 36
  • 97 (a)
XCL2 35
  • 98.25 (n)
  • 94.74 (a)
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
XCL1 36
  • 67 (a)
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
(Mus musculus)
Mammalia Xcl1 36
  • 61 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
-- 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
(Gallus gallus)
Aves IFNG 36
  • 28 (a)
Species with no ortholog for XCL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XCL2 Gene

Gene Tree for XCL2 (if available)
Gene Tree for XCL2 (if available)

Paralogs for XCL2 Gene

Paralogs for XCL2 Gene

Selected SIMAP similar genes for XCL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XCL2: view

Variants for XCL2 Gene

Sequence variations from dbSNP and Humsavar for XCL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs470289 -- 168,543,609(+) TGTCT(C/G)TTATT intron-variant
rs470290 -- 168,543,614(+) CTTAT(A/T)CTATT intron-variant
rs470510 -- 168,544,688(-) AATAA(A/G)TTGGT upstream-variant-2KB
rs470733 -- 168,540,884(-) CTGAG(A/T)TTATA utr-variant-3-prime
rs474414 -- 168,544,082(+) TGGGT(A/G)TAGGA upstream-variant-2KB

Relevant External Links for XCL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for XCL2 Gene

Disorders for XCL2 Gene

No disorders were found for XCL2 Gene.

No data available for UniProtKB/Swiss-Prot for XCL2 Gene

Publications for XCL2 Gene

  1. Molecular cloning of a novel C or gamma type chemokine, SCM-1. (PMID: 7875320) Yoshida T. … Yoshie O. (FEBS Lett. 1995) 2 3
  2. Structure and expression of two highly related genes encoding SCM- 1/human lymphotactin. (PMID: 8849694) Yoshida T. … Yoshie O. (FEBS Lett. 1996) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for XCL2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate XCL2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for XCL2
    • Block miRNA regulation of XCL2 using miScript Target Protectors

    Sources for XCL2 Gene

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