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Aliases for XCL2 Gene

Aliases for XCL2 Gene

  • X-C Motif Chemokine Ligand 2 2 3
  • Chemokine (C Motif) Ligand 2 2 3 5
  • Small Inducible Cytokine Subfamily C, Member 2 2 3
  • XC Chemokine Ligand 2 3 4
  • C Motif Chemokine 2 3 4
  • SCYC2 3 4
  • SCM-1b 3
  • SCM1B 3

External Ids for XCL2 Gene

Previous HGNC Symbols for XCL2 Gene

  • SCYC2

Previous GeneCards Identifiers for XCL2 Gene

  • GC01M166145
  • GC01M164161
  • GC01M165206
  • GC01M165697
  • GC01M165242
  • GC01M166776
  • GC01M139756

Summaries for XCL2 Gene

GeneCards Summary for XCL2 Gene

XCL2 (X-C Motif Chemokine Ligand 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include chemokine activity. An important paralog of this gene is XCL1.

UniProtKB/Swiss-Prot for XCL2 Gene

  • Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XCL2 Gene

Genomics for XCL2 Gene

Regulatory Elements for XCL2 Gene

Enhancers for XCL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around XCL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for XCL2 Gene

168,540,765 bp from pter
168,543,997 bp from pter
3,233 bases
Minus strand

Genomic View for XCL2 Gene

Genes around XCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XCL2 Gene

Proteins for XCL2 Gene

  • Protein details for XCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytokine SCM-1 beta
    Protein Accession:

    Protein attributes for XCL2 Gene

    114 amino acids
    Molecular mass:
    12567 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XCL2 Gene

Proteomics data for XCL2 Gene at MOPED

Post-translational modifications for XCL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XCL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XCL2 Gene

Domains & Families for XCL2 Gene

Gene Families for XCL2 Gene

Protein Domains for XCL2 Gene

Suggested Antigen Peptide Sequences for XCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine gamma family.
  • Belongs to the intercrine gamma family.
genes like me logo Genes that share domains with XCL2: view

Function for XCL2 Gene

Molecular function for XCL2 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic activity for lymphocytes but not for monocytes or neutrophils.
genes like me logo Genes that share phenotypes with XCL2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XCL2 Gene

Localization for XCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XCL2 Gene


Subcellular locations from

Jensen Localization Image for XCL2 Gene COMPARTMENTS Subcellular localization image for XCL2 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for XCL2 Gene

Pathways & Interactions for XCL2 Gene

genes like me logo Genes that share pathways with XCL2: view

Gene Ontology (GO) - Biological Process for XCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 7875320
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0008015 blood circulation TAS 7875320
genes like me logo Genes that share ontologies with XCL2: view

No data available for SIGNOR curated interactions for XCL2 Gene

Drugs & Compounds for XCL2 Gene

No Compound Related Data Available

Transcripts for XCL2 Gene

mRNA/cDNA for XCL2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XCL2 Gene

Chemokine (C motif) ligand 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for XCL2 Gene

No ASD Table

Relevant External Links for XCL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XCL2 Gene

mRNA expression in normal human tissues for XCL2 Gene

mRNA differential expression in normal tissues according to GTEx for XCL2 Gene

This gene is overexpressed in Whole Blood (x22.7) and Spleen (x10.7).

SOURCE GeneReport for Unigene cluster for XCL2 Gene Hs.458346

genes like me logo Genes that share expression patterns with XCL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for XCL2 Gene

Orthologs for XCL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XCL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia XCL2 35
  • 98.25 (n)
  • 94.74 (a)
-- 36
  • 95 (a)
-- 36
  • 97 (a)
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
XCL1 36
  • 67 (a)
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
-- 36
  • 44 (a)
(Mus musculus)
Mammalia Xcl1 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
(Gallus gallus)
Aves IFNG 36
  • 28 (a)
Species with no ortholog for XCL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XCL2 Gene

Gene Tree for XCL2 (if available)
Gene Tree for XCL2 (if available)

Paralogs for XCL2 Gene

Paralogs for XCL2 Gene

(14) SIMAP similar genes for XCL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XCL2: view

Variants for XCL2 Gene

Sequence variations from dbSNP and Humsavar for XCL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4301615 - 168,542,087(+) CCTAT(C/G)TGAGA reference, missense
rs4501820 - 168,542,083(+) TCCTC(C/T)TATGT reference, missense
rs474414 -- 168,544,082(+) TGGGT(A/G)TAGGA upstream-variant-2KB
rs475282 -- 168,544,141(+) AAAAA(A/T)GTCCC upstream-variant-2KB
rs475361 -- 168,544,169(+) ACCTA(A/T)CGCCT upstream-variant-2KB

Variation tolerance for XCL2 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for XCL2 Gene

Disorders for XCL2 Gene

Relevant External Links for XCL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for XCL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XCL2 Gene

Publications for XCL2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Molecular cloning of a novel C or gamma type chemokine, SCM-1. (PMID: 7875320) Yoshida T. … Yoshie O. (FEBS Lett. 1995) 2 3
  3. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. (PMID: 25449536) Suviolahti E. … Toyoda M. (Transpl. Immunol. 2015) 3
  4. Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily. (PMID: 25497737) Fox J.C. … Volkman B.F. (Cytokine 2015) 3
  5. Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. (PMID: 25092091) Li M.H. … Ferrer F. (J. Pediatr. Surg. 2014) 3

Products for XCL2 Gene

Sources for XCL2 Gene